Jibo Zhao, Yuan-li Li, Dengyun Xia, Xiaojia Sun, Yuan Zhang, Fulong Li, J. Teng
Objective: To explore the effects of goal-directed fluid therapy (GDFT) on lung function, cognitive function and inflammatory response in patients undergoing radical esophageal cancer surgery under one-lung ventilation. Methods: Sixty-seven patients undergoing radical esophageal cancer surgery were divided into GDFT group (GDFT therapy) and control group (conventional liquid therapy). The changes in patients’ pulmonary function, cognitive function and inflammatory response were evaluated. Results: Both alveolar-arterial oxygen partial pressure difference [P(A-a)O2] and respiratory index (RI) increased at one-lung ventilation for 30 minutes (T2) and decreased at one-lung ventilation for 60 minutes (T3), and after surgery (T4) in the two groups, and the GDFT group was lower than the control group (P 0.05); theoxygenation index (OI) of the two groups decreased at T2, T3, and T4 compared with that at T1 (before one-lung ventilation), and the GDFT group was higher than the control group (P 0.05). At T4 and T5, the tumor necrosis factor α (TNF-α), interleukin 6 (IL-6), central nervous system specific protein (S100β), and neuron specific enolase (NSE) in the GDFT group were lower compared to the control group (P 0.05), while interleukin-10 (IL-10) was higher compared to the control group (P 0.05); the incidence of perioperative neurocognitive disorder (PND) in the GDFT group was lower than that in the control group (P 0.05). Conclusion: GDFT can help prevent lung injury during radical esophageal cancer surgery under one-lung ventilation, reduce the body’s inflammatory response, and reduce the incidence of perioperative cognitive disorder to a certain extent.
{"title":"Effect of Goal-Directed Fluid Therapy on Lung Function, Cognitive Function and Inflammatory Response in Patients Undergoing Radical Esophageal Cancer Surgery under One-Lung Ventilation","authors":"Jibo Zhao, Yuan-li Li, Dengyun Xia, Xiaojia Sun, Yuan Zhang, Fulong Li, J. Teng","doi":"10.4236/jct.2021.129042","DOIUrl":"https://doi.org/10.4236/jct.2021.129042","url":null,"abstract":"Objective: To explore the effects of goal-directed fluid therapy (GDFT) on lung \u0000function, cognitive function and inflammatory response in patients undergoing \u0000radical esophageal cancer surgery under one-lung ventilation. Methods: Sixty-seven patients undergoing radical esophageal cancer surgery were divided \u0000into GDFT group (GDFT \u0000therapy) and control group (conventional \u0000liquid therapy). The changes in patients’ pulmonary function, cognitive function and inflammatory response were \u0000evaluated. Results: Both alveolar-arterial oxygen partial pressure \u0000difference [P(A-a)O2] \u0000and respiratory index (RI) \u0000increased at one-lung ventilation for 30 minutes (T2) and decreased \u0000at one-lung ventilation for 60 minutes (T3), and after surgery (T4) in the two groups, and \u0000the GDFT group was lower than the control group (P 0.05); \u0000theoxygenation index (OI) of the two groups decreased at T2, T3, \u0000and T4 compared with that at T1 (before one-lung ventilation), and the GDFT group was higher than the control \u0000group (P 0.05). At T4 and \u0000T5, the tumor necrosis factor α (TNF-α), interleukin 6 (IL-6), \u0000central nervous system specific protein (S100β), and neuron specific enolase (NSE) in the GDFT group were lower \u0000compared to the control group (P 0.05), \u0000while interleukin-10 (IL-10) was higher compared to the control group (P 0.05); the incidence of perioperative neurocognitive \u0000disorder (PND) in the GDFT group was lower than that in the control group (P 0.05). Conclusion: GDFT can help prevent lung \u0000injury during radical esophageal cancer surgery under one-lung ventilation, \u0000reduce the body’s \u0000inflammatory response, and reduce the incidence of perioperative cognitive \u0000disorder to a certain extent.","PeriodicalId":66197,"journal":{"name":"癌症治疗(英文)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44095078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hiba Sboui, A. Daldoul, Nader Slema, Amal Chamsi, S. Zaied
Introduction: Malignant gliomas refer to grade III or IV brain tumors defined according to the World Health Organization (WHO) classification. They are a heterogeneous group of pathologies and represent a serious health problem by their frequency, severity and treatment difficulties. The prognosis of malignant gliomas remains poor despite all the medical advances. Materials and Methods: It is a retrospective study included 20 cases of malignant glial tumors treated at the medical oncology department, Fattouma Bourguiba hospital in Monastir between 2012 and 2016, according to the STUPP protocol. Results: These were 12 men and 8 women with a median age of 43. Clinical signs were not very specific, dominated by intracranial hypertension and deficit signs. Imagery referred to the diagnosis of malignant gliomas in 1st intention. Surgery consisted of a macroscopically complete exeresis in (15%) cases, a partial exeresis in (50%), the rest of the patients had a stereotactic biopsy. Histology found GBM in 16 patients (80%), 2 cases of Grade III anaplastic astrocytoma (10%), 1 case of anaplastic oligodendroglioma (5%), and 1 case of Grade III anaplastic eppendymoma (5%). Most of our patients received concurrent radio-chemotherapy and adjuvant TMZ chemotherapy was administered in 15 patients, 7 of whom received the full 6 scheduled cures. A relapse treatment was decided in only one of the 12 patients who relapsed. 6 patients are still alive. The median survival is 11.27 months. In our series, overall survival was related to histological type (p = 0.006) and neurological status assessed at the end of RT-CT (p = 0.001). While age, general condition score, type of surgery, and post-therapeutic development did not show a statistically significant relationship, although survival rates were consistent with the criteria assessed. Conclusion: Malignant gliomas are rare tumors, bad prognosis, aggravated in Tunisia by a diagnostic delay. The creation of a multidisciplinary neuro-oncology group can help to improve management.
{"title":"Management of Malignants Gliomas: About 20 Cases Treated in the Medical Oncology Department of Fattouma Bourguiba University Hospital-Monastir","authors":"Hiba Sboui, A. Daldoul, Nader Slema, Amal Chamsi, S. Zaied","doi":"10.4236/jct.2021.128041","DOIUrl":"https://doi.org/10.4236/jct.2021.128041","url":null,"abstract":"Introduction: Malignant gliomas refer to grade III or IV brain tumors defined according to the World Health Organization \u0000(WHO) classification. They are a \u0000heterogeneous group of pathologies and represent a serious health problem by their frequency, severity and treatment difficulties. The prognosis \u0000of malignant gliomas remains poor despite all the medical advances. Materials and Methods: It is a retrospective study included 20 cases of \u0000malignant glial tumors treated at the \u0000medical oncology department, Fattouma Bourguiba hospital in Monastir \u0000between 2012 and 2016, according to the STUPP protocol. Results: These \u0000were 12 men and 8 women with a median age of 43. Clinical signs were not very \u0000specific, dominated by intracranial hypertension and deficit signs. Imagery referred to the diagnosis of malignant gliomas in \u00001st intention. Surgery consisted of a macroscopically complete exeresis \u0000in (15%) cases, a partial exeresis in (50%), the rest of the patients had a \u0000stereotactic biopsy. Histology found GBM in 16 patients (80%), 2 cases of Grade \u0000III anaplastic astrocytoma (10%), 1 case of anaplastic oligodendroglioma (5%), \u0000and 1 case of Grade III anaplastic eppendymoma (5%). Most of our patients \u0000received concurrent radio-chemotherapy and adjuvant TMZ chemotherapy was \u0000administered in 15 patients, 7 of whom received the full 6 scheduled cures. A \u0000relapse treatment was decided in only one of the 12 patients who relapsed. 6 \u0000patients are still alive. The median survival is 11.27 months. In our series, \u0000overall survival was related to histological type (p = 0.006) and neurological \u0000status assessed at the end of RT-CT (p = 0.001). While age, general condition \u0000score, type of surgery, and post-therapeutic development did not show a statistically significant \u0000relationship, although survival rates were consistent with the criteria assessed. Conclusion: Malignant gliomas are rare \u0000tumors, bad prognosis, aggravated in Tunisia by a diagnostic \u0000delay. The creation of a multidisciplinary neuro-oncology group can help to \u0000improve management.","PeriodicalId":66197,"journal":{"name":"癌症治疗(英文)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47731919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
E. R. Vickers, Junqing Liang, Peter G. Vickers, Haitao Wen
Surgery, chemotherapy and radiotherapy are the gold standard treatments used for cancer. Side effects from medical radiation can be significant, particularly external beam therapy to the breast, and head and neck regions causing fibrosis, secondary skin cancer, hair loss, oral mucositis and neuropathic pain. There is significant psychological stress, depression, anxiety and loss of self esteem particularly for female patients. Similar types of space radiation are known to damage the health of astronauts. Current treatments for scarring, tissue loss, hair loss and neuropathic pain are a high priority but inadequate. Regenerative medicine is a new and comprehensive approach to potentially treat complex medical conditions from radiation damage. Regenerative medicine combines a systematic evidence based approach with the use of herbal medicine, stem cells, peptides and 3D tissue engineering. These fields use sophisticated technology to identify the respective molecular mechanisms of upregulation and protection of healthy cells and down regulation of cancer cells. The regenerative medicine strategies of stem cells and plant polyphenols suggest there is significant potential for rapid clinical translation to alleviate the side effects associated with radiotherapy.
{"title":"Regenerative Medicine to Reduce the Side Effects from Radiotherapy Causing Skin Cancer, Fibrosis, Neuropathic Pain and Hair Loss","authors":"E. R. Vickers, Junqing Liang, Peter G. Vickers, Haitao Wen","doi":"10.4236/jct.2021.128040","DOIUrl":"https://doi.org/10.4236/jct.2021.128040","url":null,"abstract":"Surgery, chemotherapy and radiotherapy are the gold \u0000standard treatments used for cancer. Side effects from medical \u0000radiation can be significant, particularly external beam therapy to the breast, \u0000and head and neck regions causing fibrosis, \u0000secondary skin cancer, hair loss, oral mucositis and neuropathic pain. \u0000There is significant psychological stress, depression, anxiety and loss of self \u0000esteem particularly for female patients. Similar types of space radiation are \u0000known to damage the health of astronauts. Current treatments for scarring, \u0000tissue loss, hair loss and neuropathic pain are a high priority but inadequate. \u0000Regenerative medicine is a new and comprehensive approach to potentially treat \u0000complex medical conditions from radiation damage. Regenerative medicine \u0000combines a systematic evidence based approach with the use of herbal medicine, \u0000stem cells, peptides and 3D tissue engineering. These fields use sophisticated \u0000technology to identify the respective molecular mechanisms of upregulation and \u0000protection of healthy cells and down regulation of cancer cells. The \u0000regenerative medicine strategies of stem cells and plant polyphenols suggest \u0000there is significant potential for rapid clinical translation to alleviate the \u0000side effects associated with radiotherapy.","PeriodicalId":66197,"journal":{"name":"癌症治疗(英文)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44891527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Y. Feng, Xi Liu, X. Pan, Chang Hu, Ning Zhan, Zongda Zhu, Zhenxiang Deng
Purpose: Verified the delivered dose distribution of lung cancer Stereotactic Body Radiotherapy (SBRT) using the cone-beam CT images. Methods: Twenty lung cancer patients who underwent SBRT with 100 CBCT images were enrolled in this study. Delivered dose distributions were recalculated on CBCT images with the deformed and non-deformed methods, respectively. The planned and delivered dose distributions were compared using the dose-volume histograms. Results: The delivered target coverage (V100) per patient inside target volume deviated on average were 0.83% ± 0.86% and 1.38% ± 1.40% for Pct vs. Pcbct and Pct vs. Pdcbct, respectively. The Conformity Index (CI) and Gradient Index (GI) showed a good agreement among the plans. For the critical organs, only minor differences were observed between the planned dose and the delivered dose. Conclusions: CBCT images were a useful tool for setup and dose delivery verification for lung cancer patients who underwent SBRT.
{"title":"Delivered Dose Verification for Lung Cancer Stereotactic Body Radiotherapy Using Cone-Beam CT","authors":"Y. Feng, Xi Liu, X. Pan, Chang Hu, Ning Zhan, Zongda Zhu, Zhenxiang Deng","doi":"10.4236/jct.2021.127039","DOIUrl":"https://doi.org/10.4236/jct.2021.127039","url":null,"abstract":"Purpose: Verified the delivered dose distribution of lung \u0000cancer Stereotactic Body Radiotherapy (SBRT) \u0000using the cone-beam CT images. Methods: Twenty lung cancer patients who underwent SBRT with 100 CBCT \u0000images were enrolled in this study. Delivered dose distributions \u0000were recalculated on CBCT images with the deformed and non-deformed methods, respectively. The planned and delivered dose distributions were compared using the dose-volume histograms. Results: The delivered target coverage (V100) \u0000per patient inside target volume deviated on average were 0.83% ± 0.86% and \u00001.38% ± 1.40% for Pct vs. Pcbct and Pct vs. Pdcbct, respectively. The \u0000Conformity Index (CI) and Gradient Index (GI) showed a good agreement among the \u0000plans. For the critical organs, only minor differences were observed between \u0000the planned dose and the delivered dose. Conclusions: CBCT images were a useful tool for setup and dose delivery verification for lung cancer patients who underwent SBRT.","PeriodicalId":66197,"journal":{"name":"癌症治疗(英文)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41329765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Erika Myriam Baiguerel, R. S. Tagne, A. H. K. Nwabo, C. Nangue, Ahmadou Mohamadou, P. F. S. Etet, P. Telefo
Due to the late diagnosis, resulting partly from the absence of national screening programs, breast cancer has become a real public health problem in Cameroon, particularly in rural areas. This work aimed to assess breast cancer awareness in the North Region of Cameroon. Participants were selected randomly in six health centers surrounding rural areas of Garoua, North Region of Cameroon, and administered a questionnaire aimed at assessing their awareness about breast cancer warning signs and screening methods. Out of 475 women (including 37 medical personnel) interviewed, 23.3% had misconceptions and myth-based ideas on the origin of the disease. Employed women were more aware of breast cancer, its risk factors and symptoms as compared to other groups (p < 0.0001) for most of the risk factors and symptoms. Participants with higher education and employed women were also more aware of breast cancer screening, including breast self-examination mammography, and breast ultrasound (p < 0.0001 vs. other groups). Breast cancer screening and breast self-examination were mostly performed by women with higher education and employed women (p < 0.0001 compared to other groups). Ignorance was the main reason preventing women from performing breast self-examination and the high cost prevented going for mammography. Our study highlights the need to raise awareness among the populations in Cameroon North Region about the risk factors and clinical signs of breast cancer and the importance of screening practice for the early diagnosis of breast cancer.
{"title":"Breast Cancer and Its Screening Awareness in the North Region of Cameroon","authors":"Erika Myriam Baiguerel, R. S. Tagne, A. H. K. Nwabo, C. Nangue, Ahmadou Mohamadou, P. F. S. Etet, P. Telefo","doi":"10.4236/jct.2021.127037","DOIUrl":"https://doi.org/10.4236/jct.2021.127037","url":null,"abstract":"Due to the late diagnosis, resulting partly from the \u0000absence of national screening programs, breast cancer has become a real \u0000public health problem in Cameroon, particularly in rural areas. This work aimed \u0000to assess breast cancer awareness in the North Region of Cameroon. Participants \u0000were selected randomly in six health centers surrounding rural areas of \u0000Garoua, North Region of Cameroon, and administered a questionnaire aimed at assessing their \u0000awareness about breast cancer warning signs and screening methods. Out of 475 \u0000women (including 37 medical personnel) interviewed, 23.3% had misconceptions \u0000and myth-based ideas on the origin of the disease. Employed women were more \u0000aware of breast cancer, its risk factors and symptoms as compared to other \u0000groups (p < 0.0001) for most of the risk factors and symptoms. Participants \u0000with higher education and employed women were also more aware of breast cancer \u0000screening, including breast self-examination mammography, and breast ultrasound \u0000(p < 0.0001 vs. other groups). Breast cancer screening and breast \u0000self-examination were mostly performed by women with higher education and \u0000employed women (p < 0.0001 compared to other groups). Ignorance was the main \u0000reason preventing women from performing breast self-examination and the high \u0000cost prevented going for mammography. Our study highlights the need to raise \u0000awareness among the populations in Cameroon North Region about the risk factors \u0000and clinical signs of breast cancer and the importance of screening practice \u0000for the early diagnosis of breast cancer.","PeriodicalId":66197,"journal":{"name":"癌症治疗(英文)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41983727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Harrak, S. Lemsanes, S. Razine, S. Najem, Khadija Benchekroun, Saad Lannaz, H. Mrabti, H. Errihani
Background: Ewing’s Sarcoma (ES)/peripheral Primitive Neuroectodermal Tumor (pPNET) is a rare aggressive malignant small round cell tumour. Most of them arise in bony sites, and they represent the second commonest primary osseous malignancy in adolescence and young adults. The localization of the small bowel is very rare, to our knowledge only 35 cases of ES/pPNET of the small bowel have been reported in the literature. Case Presentation: We report a case of pPNET of the ileum in a 26-year-old female, presented abdominal pain with a transit disorder. The clinical examination was unremarkable. The histological and immunohistochemical study confirmed the diagnosis of peripheral primary neuroectodermal tumours. The patient was treated by tumor resection followed by adjuvant chemotherapy. The evolution was good, without recurrence with a follow-up of 12 months. Conclusion: PNET of the ileum is very rare. We report this case to enrich the database of this rare clinical entity and to improve the management of patients with PNET of the ileum.
{"title":"Peripheral Primary Neuroectodermal Tumour of the Ileum: A Case Report and Review of the Literature","authors":"S. Harrak, S. Lemsanes, S. Razine, S. Najem, Khadija Benchekroun, Saad Lannaz, H. Mrabti, H. Errihani","doi":"10.4236/jct.2021.127035","DOIUrl":"https://doi.org/10.4236/jct.2021.127035","url":null,"abstract":"Background: Ewing’s Sarcoma (ES)/peripheral Primitive \u0000Neuroectodermal Tumor (pPNET) is a rare aggressive malignant small round cell \u0000tumour. Most of them arise in bony sites, and they represent the second \u0000commonest primary osseous malignancy in adolescence and young adults. The \u0000localization of the small bowel is very rare, to our knowledge only 35 cases of \u0000ES/pPNET of the small bowel have been reported in the literature. Case Presentation: We report a case of pPNET of the ileum in a 26-year-old female, presented abdominal pain with a transit disorder. The \u0000clinical examination was unremarkable. The histological and immunohistochemical \u0000study confirmed the diagnosis of peripheral primary neuroectodermal tumours. \u0000The patient was treated by tumor resection followed by adjuvant chemotherapy. \u0000The evolution was good, without recurrence with a follow-up of 12 months. Conclusion: PNET of the ileum is very rare. We report this case to enrich the database of this rare clinical entity \u0000and to improve the management of patients with PNET of the ileum.","PeriodicalId":66197,"journal":{"name":"癌症治疗(英文)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49603849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Rectal cancer predominantly occurs in older adults. We aimed to compare the long-term outcomes of older adults (≥70 years) versus younger adults (Methods: Consecutive patients who had resection of a primary rectal cancer between January 1, 2000 and December 31, 2010 were identified from a prospective database at the Concord Repatriation General Hospital and stratified into two age groups: ences in patients, cancer, and treatment characteristics were determined by Chi-square tests. 5-year Overall Survival (OS) and Cancer-Specific Survival (CSS) were determined by the Kaplan-Meier method and by multivariable Cox regression analysis. Results: Of 714 included patients, the mean age was 65.8 years (range, 21 - 92 years). 407 (57%) patients were aged 70 years. Older age (>70 years) predicted more comorbidity (p 70 years), compared with younger adults (Conclusion: Older adults who had had a resection of stage I-IV primary rectal cancer received less neoadjuvant and adjuvant therapy and had worse OS and CSS than their younger counterparts.
{"title":"Five Year Survival Outcomes of Prospectively Recorded Cohort Data for Older Adults versus Younger Adults with Resected Primary Rectal Cancer","authors":"M. Shafiei, P. Beale, P. Blinman","doi":"10.4236/jct.2021.127038","DOIUrl":"https://doi.org/10.4236/jct.2021.127038","url":null,"abstract":"Background: Rectal cancer predominantly occurs in older adults. \u0000We aimed to compare the long-term outcomes \u0000of older adults (≥70 years) versus younger adults (Methods: Consecutive patients who had resection of a primary rectal cancer between \u0000January 1, 2000 and December 31, 2010 were identified from a prospective \u0000database at the Concord Repatriation General Hospital and stratified into two age groups: ences in \u0000patients, cancer, and treatment characteristics were determined by Chi-square tests. 5-year Overall Survival (OS) and Cancer-Specific Survival (CSS) \u0000were determined by the Kaplan-Meier method and by multivariable Cox \u0000regression analysis. Results: Of 714 included patients, the mean age was \u000065.8 years (range, 21 - 92 years). 407 (57%) patients were aged 70 years. Older age (>70 years) predicted more comorbidity (p 70 years), compared with younger adults (Conclusion: Older adults who had had a resection of stage I-IV primary rectal cancer \u0000received less neoadjuvant and adjuvant therapy and had worse OS and CSS than \u0000their younger counterparts.","PeriodicalId":66197,"journal":{"name":"癌症治疗(英文)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45498915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
H. Sallinen, Vivi Rintanen, L. Keski-Nisula, M. Anttila
Aim: Despite recent advances in the treatment of ovarian cancer, recurrence of the disease is still frequent. This study evaluated whether multiple lines of chemotherapy have impact on overall survival (OS), progression free survival (PFS) or on treatment free intervals (TFIs) after serial chemotherapy lines in recurrent settings. Methods: A total of 189 patients with ovarian cancer (including fallopian tube and primary peritoneal cancer), who were treated in Kuopio University Hospital in Finland during 2009-2014, were enrolled. The medical files of these patients were retrospectively reviewed. Results: Median OS and PFS were significantly higher at the time of the first relapse compared to subsequent relapses (p platinum sensitive, semi-sensitive and platinum resistant patients. The total amount of TFI times during the whole follow-up time was significantly reduced in those patients that received at least one form of aggressive care at the end of life (p = 0.004). Conclusions: Ovarian cancer patients received often multiple lines of chemotherapy. TFIs after subsequent chemotherapy lines decreased during the disease course. More efforts should be taken to avoid unnecessary and ineffective treatments especially in recurrent phase of the disease.
{"title":"Treatment Free Intervals after Subsequent Chemotherapy Lines in Recurrent Ovarian Cancer","authors":"H. Sallinen, Vivi Rintanen, L. Keski-Nisula, M. Anttila","doi":"10.4236/JCT.2021.126031","DOIUrl":"https://doi.org/10.4236/JCT.2021.126031","url":null,"abstract":"Aim: Despite recent advances in the treatment of ovarian cancer, recurrence \u0000of the disease is still frequent. This study evaluated whether multiple lines \u0000of chemotherapy have impact on overall survival (OS), progression free survival \u0000(PFS) or on treatment free intervals (TFIs) after serial chemotherapy lines in \u0000recurrent settings. Methods: A total of 189 patients with ovarian cancer (including fallopian tube and \u0000primary peritoneal cancer), who were treated in Kuopio University Hospital in \u0000Finland during 2009-2014, were enrolled. The medical files of these patients \u0000were retrospectively reviewed. Results: Median OS and PFS were significantly higher at the time of the first \u0000relapse compared to subsequent relapses (p platinum sensitive, \u0000semi-sensitive and platinum resistant patients. The total amount of TFI times during the whole follow-up \u0000time was significantly reduced in those patients that received at least \u0000one form of aggressive care at the end of \u0000life (p = 0.004). Conclusions: Ovarian cancer patients received often \u0000multiple lines of chemotherapy. TFIs after \u0000subsequent chemotherapy lines decreased \u0000during the disease course. More efforts should be taken to avoid unnecessary \u0000and ineffective treatments especially in recurrent phase of the disease.","PeriodicalId":66197,"journal":{"name":"癌症治疗(英文)","volume":"12 1","pages":"346-357"},"PeriodicalIF":0.0,"publicationDate":"2021-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44662003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rhabdomyosarcoma is a rare and aggressive mesenchymal tumor, whose paratesticular location is the most common genitourinary site. It is the prerogative of the child and the young adult. On physical examination, a painless scrotal tumefaction is observed. His diagnosis is essentially provided by testicular ultrasound. His therapeutic strategy is codified and based on the combination of chemotherapy and surgical excision or radiotherapy. The precocity of the management and the accuracy of the extension and radiology tests are important for the vital and functional prognosis. We report a case of paratesticular rhabdomysarcoma of alveolar type, diagnosed in front of a large left painless scrotal mass, which has been evolving for less than one month in a 7-year-old child. An inguinal orchiectomy was performed. A histological examination of the excised tissue revealed an epididymal RMS of the alveolar type. Our patient had 9 chemotherapy sessions with vincristine, actinomycin C and cyclophosphamide. Each chemotherapy session took place over four days, with a 21-day cycle. He was evaluated for 4 years and demonstrated good clinical improvement. The experience gained from the index case is crucial for the management of patients with intratesticular rhabdomyosarcoma who must always ensure that the radical inguinal orchiectomy with lymph node dissection is covered by chemotherapy and/or radiotherapy. This will potentially reduce the chances of tumor recurrence and/or metastasis, thus improving patient prognosis.
{"title":"Case Report: The Paratesticular Rhabdomyosarcoma in Children","authors":"M. Azizi, A. Babakhouya, M. Rkain, N. Benajiba","doi":"10.4236/JCT.2021.126032","DOIUrl":"https://doi.org/10.4236/JCT.2021.126032","url":null,"abstract":"Rhabdomyosarcoma is a rare and aggressive mesenchymal tumor, whose \u0000paratesticular location is the most common genitourinary site. It is the \u0000prerogative of the child and the young adult. \u0000On physical examination, a painless scrotal tumefaction is observed. His \u0000diagnosis is essentially provided by testicular ultrasound. His therapeutic \u0000strategy is codified and based on the combination of chemotherapy and surgical \u0000excision or radiotherapy. The precocity of the management and the \u0000accuracy of the extension and radiology tests are important for the vital and \u0000functional prognosis. We report a case of paratesticular rhabdomysarcoma of \u0000alveolar type, diagnosed in front of a large left painless scrotal mass, which \u0000has been evolving for less than one month in a 7-year-old \u0000child. An inguinal orchiectomy was performed. A histological examination of the \u0000excised tissue revealed an epididymal RMS of the alveolar type. Our patient had \u00009 chemotherapy sessions with vincristine, actinomycin C and cyclophosphamide. \u0000Each chemotherapy session took place over four days, with a 21-day cycle. He was evaluated for 4 years and demonstrated good clinical improvement. The experience \u0000gained from the index case is crucial for the management of patients \u0000with intratesticular rhabdomyosarcoma who must always ensure that the radical \u0000inguinal orchiectomy with lymph node dissection is covered by chemotherapy \u0000and/or radiotherapy. This will potentially \u0000reduce the chances of tumor recurrence and/or metastasis, thus improving \u0000patient prognosis.","PeriodicalId":66197,"journal":{"name":"癌症治疗(英文)","volume":"12 1","pages":"358-364"},"PeriodicalIF":0.0,"publicationDate":"2021-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45459783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
We have known since 1976 that cancer evolves clonally from one initiated normal human cell, the first cell. Today we see that this fact has been overshadowed from federal funding choice of the mutation theory (MT), which not yet has shown tumorigenesis-initiation in normal human cells. Our suggested, death signaled, stress model from time delayed S-period (replication slowness), causing repair instability from under-replicated lesions in repetitive DNAs, herein has the objective of revealing, significant literature support from a mini-review. We reasoned that early versus late S-period stress would have different outcomes: early the slowness affecting mitotic slippage with diploid re-replication to 4n cells whereas late-S, with milder stress effect, producing diploid cells. In cancer burden, near-half is diploid, but tetraploid solid tumors have the attention. The initial 4n cells were special with orderly genomic reductive division to diploid first cells with measurable fitness-gain from hours-reduced total cell cycle time. Experimental data from Coxsakie-B3 virus infected normal fibroblasts, reiterated 4n cell production from death-signaled recovery-cells with progressive cell-phenotypic changes to polygonal and roundness cell-shapes, indistinguishable from diagnostic/prognostic cancer morphology. The 4n cells showed a self-inflicted 90° turn of the 4n nucleus before division, affecting a perpendicular orientation of the fitness-gained first cells relative to neighboring cells. In an illustrated cell cycle drawing with early and late S-period stress, it became clear that coding genes on borders of repair unstable satellite, repetitive DNA regions, could become mutated. We found these mutations to be tumor SMGs (significantly mutated genes). Evidential material was presented for loss of function genetics driving tumorigenesis to a parasitic lifestyle.
{"title":"A Traceable Cancer Model: DNA Damage, Fragile Site-SMGs, Mitotic Slippage, 4n-Genome-Reduction to Fitness-Gained, Initiating, 2n First Cells","authors":"K. Walen","doi":"10.4236/jct.2021.126033","DOIUrl":"https://doi.org/10.4236/jct.2021.126033","url":null,"abstract":"We have known since 1976 that cancer evolves clonally from one initiated normal human cell, the first cell. \u0000Today we see that this fact has been overshadowed from federal funding choice \u0000of the mutation theory (MT), which not yet has shown tumorigenesis-initiation \u0000in normal human cells. Our suggested, death signaled, stress model from time \u0000delayed S-period (replication slowness), causing repair instability from \u0000under-replicated lesions in repetitive DNAs, herein has the objective of \u0000revealing, significant literature support from a mini-review. We reasoned that \u0000early versus late S-period stress would have \u0000different outcomes: early the slowness affecting mitotic slippage with diploid re-replication to 4n cells whereas late-S, \u0000with milder stress effect, producing \u0000diploid cells. In cancer burden, near-half is diploid, but tetraploid solid tumors have the attention. The initial 4n cells were special with orderly \u0000genomic reductive division to diploid first cells with measurable fitness-gain \u0000from hours-reduced total cell cycle time. Experimental data from Coxsakie-B3 \u0000virus infected normal fibroblasts, reiterated 4n cell production from death-signaled recovery-cells with \u0000progressive cell-phenotypic changes to polygonal and roundness cell-shapes, \u0000indistinguishable from diagnostic/prognostic cancer morphology. The 4n cells showed a self-inflicted 90° turn of the 4n nucleus before division, affecting a \u0000perpendicular orientation of the fitness-gained first cells relative to \u0000neighboring cells. In an illustrated cell cycle drawing with early and late \u0000S-period stress, it became clear that coding genes on borders of repair \u0000unstable satellite, repetitive DNA regions, could become mutated. We found \u0000these mutations to be tumor SMGs (significantly mutated genes). Evidential \u0000material was presented for loss of function genetics driving tumorigenesis to a \u0000parasitic lifestyle.","PeriodicalId":66197,"journal":{"name":"癌症治疗(英文)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41555128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：