Objective To investigate the correlation between the expression of (epidermal growth factor receptor-2, HER-2) and clinicopathological features and survival of colorectal cancer. Methods From Jan 2005 to Dec 2015, all colorectal cancer cases were enrolled that the expression levels of HER-2 were detected in Guangdong Provincial People′s Hospital. Clinicopathological features of the tumors and survival of the patients were analyzed . Results A total of 1 463 cases were collected in 10 years, including 711 cases (48.6%) of HER-2 (-), 470 cases (32.1%) of HER-2 (+ ), 249 cases (17%) of HER-2 (+ + ), and 33 cases (2.3%) of HER-2 (+ + + ). Correlation analysis shows that the expression levels of HER-2 were significantly correlated with tumor differentiation and the depth of tumor invasion(T stage), but not correlated with gender, age, tumor location, N stage, M stage, TNM stage and overall survival, and disease-free survival. Conclusion The expression of HER-2 may be related to tumor differentiation and growth infiltration, but it cannot be used as a predictor of prognosis in patients with colorectal cancer. Key words: Colorectal neoplasms; Receptor, epidermal growth factor; Pathology, clinical; Prognosis
{"title":"Expression of HER-2 in colorectal cancer and its relationship with clinicopathological features and prognosis","authors":"Wulin Wu, Zejian Lyu, Zifeng Yang, Q. Yan, Yuwen Luo, W. Liang, Deqing Wu, Weixian Hu, Guanfu Cai, Xue-qing Yao, Yong Li","doi":"10.3760/CMA.J.ISSN.1007-631X.2019.12.013","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1007-631X.2019.12.013","url":null,"abstract":"Objective \u0000To investigate the correlation between the expression of (epidermal growth factor receptor-2, HER-2) and clinicopathological features and survival of colorectal cancer. \u0000 \u0000 \u0000Methods \u0000From Jan 2005 to Dec 2015, all colorectal cancer cases were enrolled that the expression levels of HER-2 were detected in Guangdong Provincial People′s Hospital. Clinicopathological features of the tumors and survival of the patients were analyzed . \u0000 \u0000 \u0000Results \u0000A total of 1 463 cases were collected in 10 years, including 711 cases (48.6%) of HER-2 (-), 470 cases (32.1%) of HER-2 (+ ), 249 cases (17%) of HER-2 (+ + ), and 33 cases (2.3%) of HER-2 (+ + + ). Correlation analysis shows that the expression levels of HER-2 were significantly correlated with tumor differentiation and the depth of tumor invasion(T stage), but not correlated with gender, age, tumor location, N stage, M stage, TNM stage and overall survival, and disease-free survival. \u0000 \u0000 \u0000Conclusion \u0000The expression of HER-2 may be related to tumor differentiation and growth infiltration, but it cannot be used as a predictor of prognosis in patients with colorectal cancer. \u0000 \u0000 \u0000Key words: \u0000Colorectal neoplasms; Receptor, epidermal growth factor; Pathology, clinical; Prognosis","PeriodicalId":66425,"journal":{"name":"中华普通外科杂志","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42559163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective To explore the role and clinical efficacy of catheter induced thrombolysis(CDT) debulking method in the treatment of aorto-iliac artery occlusion. Methods A total of 59 patients with aorto-iliac artery occlusion who underwent endovascular treatment between June 2013 and June 2017 were enrolled. Patients were divided into PTA group and CDT group according to the treatment methods received. The PTA group received a balloon-expandable stent placement, and the CDT group underwent thrombolytic therapy for 48 to 72 hours before angiographic evaluation and further PTA treatment. Results In the CDT group, 7 cases were still unable to place the stent after thrombolysis, and 20 patients successfully received stenting including 1-stent-placement in 16 patient and 2-stents-placement in 4. In PTA group 32 patients were treated with stents placement including 1-stent-placement in 19 patients, 2-stents in 12, 3-stents in 1. Follow-up rate was 86.3% within 1 year, the patency rate was 84.21% in the PTA group, and 76.92% in the CDT group. Conclusions CDT is effective method for occlusion of the aorto-iliac artery. TASC classification of aorto-iliac arterial occlusion degrades after CDT treatment, thus reducing the use of stenting . Key words: Arterial occlusive diseases; Stents; Catheter directed thrombolysis; Debulking treatment
{"title":"Effect of debulking therapy by thrombolysis in aorto-iliac artery occlusion","authors":"Chunmin Li, Rui Leng, Hua-Liang Ren, Qi Wang, Wang-de Zhang","doi":"10.3760/CMA.J.ISSN.1007-631X.2019.12.008","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1007-631X.2019.12.008","url":null,"abstract":"Objective \u0000To explore the role and clinical efficacy of catheter induced thrombolysis(CDT) debulking method in the treatment of aorto-iliac artery occlusion. \u0000 \u0000 \u0000Methods \u0000A total of 59 patients with aorto-iliac artery occlusion who underwent endovascular treatment between June 2013 and June 2017 were enrolled. Patients were divided into PTA group and CDT group according to the treatment methods received. The PTA group received a balloon-expandable stent placement, and the CDT group underwent thrombolytic therapy for 48 to 72 hours before angiographic evaluation and further PTA treatment. \u0000 \u0000 \u0000Results \u0000In the CDT group, 7 cases were still unable to place the stent after thrombolysis, and 20 patients successfully received stenting including 1-stent-placement in 16 patient and 2-stents-placement in 4. In PTA group 32 patients were treated with stents placement including 1-stent-placement in 19 patients, 2-stents in 12, 3-stents in 1. Follow-up rate was 86.3% within 1 year, the patency rate was 84.21% in the PTA group, and 76.92% in the CDT group. \u0000 \u0000 \u0000Conclusions \u0000CDT is effective method for occlusion of the aorto-iliac artery. TASC classification of aorto-iliac arterial occlusion degrades after CDT treatment, thus reducing the use of stenting . \u0000 \u0000 \u0000Key words: \u0000Arterial occlusive diseases; Stents; Catheter directed thrombolysis; Debulking treatment","PeriodicalId":66425,"journal":{"name":"中华普通外科杂志","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44515182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-25DOI: 10.3760/CMA.J.ISSN.1007-631X.2019.12.007
Hong-Ru Deng, Mi Zhou, Chaonan Wang, Mingxuan Li, Hai-min Shan, Zhangmu Li
Objective To evaluate the clinical and technical effects of self-expanding VENA stent in the treatment of iliofemoral vein obstruction. Methods The clinical data of 58 patients(61 limbs) with symptomatic iliofemoral vein obstructive disease treated by VENA stent from February 2017 to June 2018 were collected and analyzed. The patency of the vein was assessed by the results of intraoperative angiography and postoperative symptoms relief changes in leg circumference. Follow up included relief of symptoms, Doppler ultrasound. Results A total of 63 VENA stents (43 in the left limb and 20 in the right limb) were implanted, sizes ranging from 12 mm to 16 mm, surgical technique success rate was 100%.The median follow-up time was 8.6 months. The primary patency rate of one month, three months, six months and 12 months was 96%, 94%, 92% and 92%, respectively. Leg circumference fall down from(48±0.4)cm to (37±0.3)cm(P<0.05). Conclusion Self-expanding nitinol stent implantation is a safe and effective treatment method for symptomatic iliofemoral vein obstruction disease. Key words: Venous thrombosis; Stents
{"title":"VENA stenting for symptomatic iliofemoral vein obstructive disease","authors":"Hong-Ru Deng, Mi Zhou, Chaonan Wang, Mingxuan Li, Hai-min Shan, Zhangmu Li","doi":"10.3760/CMA.J.ISSN.1007-631X.2019.12.007","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1007-631X.2019.12.007","url":null,"abstract":"Objective \u0000To evaluate the clinical and technical effects of self-expanding VENA stent in the treatment of iliofemoral vein obstruction. \u0000 \u0000 \u0000Methods \u0000The clinical data of 58 patients(61 limbs) with symptomatic iliofemoral vein obstructive disease treated by VENA stent from February 2017 to June 2018 were collected and analyzed. The patency of the vein was assessed by the results of intraoperative angiography and postoperative symptoms relief changes in leg circumference. Follow up included relief of symptoms, Doppler ultrasound. \u0000 \u0000 \u0000Results \u0000A total of 63 VENA stents (43 in the left limb and 20 in the right limb) were implanted, sizes ranging from 12 mm to 16 mm, surgical technique success rate was 100%.The median follow-up time was 8.6 months. The primary patency rate of one month, three months, six months and 12 months was 96%, 94%, 92% and 92%, respectively. Leg circumference fall down from(48±0.4)cm to (37±0.3)cm(P<0.05). \u0000 \u0000 \u0000Conclusion \u0000Self-expanding nitinol stent implantation is a safe and effective treatment method for symptomatic iliofemoral vein obstruction disease. \u0000 \u0000 \u0000Key words: \u0000Venous thrombosis; Stents","PeriodicalId":66425,"journal":{"name":"中华普通外科杂志","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46367976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-25DOI: 10.3760/CMA.J.ISSN.1007-631X.2019.12.005
Ji Wang, Hongcheng Li, Hongqin Ma, Li Liu, Wenxing Zhao
Objective To evaluate the result of laparoscopic pancreaticoduodenectomy(LPD). Methods We retrospectively analyzed the perioperative clinical data of 111 consecutive LPD procedures performed from Jan 2015 to Aug 2018 at Department of General Surgery, the Affiliated Hospital of Xuzhou Medical University. Results Of the 111 patients undergoing laparoscopic procedure, 24 patients (21.6%) had abdominal surgery history. The mean operative time was (360.9±108.9)minutes.The mean blood loss was (270.9±184.9)m1.The mean operative time of pancreatojejunostomy and choledochojejunostomy was (46.2±11.6) minutes and (19.0±7.2) minutes, respectively. The mean postoperative hospital stay was(14.9±4.7)days. The rate of pancreatic fistula grade B was 6.3% and pancreatic fistula grade A was 20.7%. The rate of bile leakage was 1.8%. Second surgical operation was necessary for 5 cases (4.5%), delayed postoperative hemorrhage occurred in 2 cases (1.8%). The mean number of lymph nodes harvested was(14.2±7.9) and the positive rate number was (0.9±1.8). Conclusions LPD improves the operation quality, reduces intraoperative hemorrhage and accelerates the postoperative recovery. Key words: Laparoscopy; Pancreaticoduodenectomy
{"title":"Total laparoscopic pancreaticoduodenectomy: a report of 111 cases in a single center","authors":"Ji Wang, Hongcheng Li, Hongqin Ma, Li Liu, Wenxing Zhao","doi":"10.3760/CMA.J.ISSN.1007-631X.2019.12.005","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1007-631X.2019.12.005","url":null,"abstract":"Objective \u0000To evaluate the result of laparoscopic pancreaticoduodenectomy(LPD). \u0000 \u0000 \u0000Methods \u0000We retrospectively analyzed the perioperative clinical data of 111 consecutive LPD procedures performed from Jan 2015 to Aug 2018 at Department of General Surgery, the Affiliated Hospital of Xuzhou Medical University. \u0000 \u0000 \u0000Results \u0000Of the 111 patients undergoing laparoscopic procedure, 24 patients (21.6%) had abdominal surgery history. The mean operative time was (360.9±108.9)minutes.The mean blood loss was (270.9±184.9)m1.The mean operative time of pancreatojejunostomy and choledochojejunostomy was (46.2±11.6) minutes and (19.0±7.2) minutes, respectively. The mean postoperative hospital stay was(14.9±4.7)days. The rate of pancreatic fistula grade B was 6.3% and pancreatic fistula grade A was 20.7%. The rate of bile leakage was 1.8%. Second surgical operation was necessary for 5 cases (4.5%), delayed postoperative hemorrhage occurred in 2 cases (1.8%). The mean number of lymph nodes harvested was(14.2±7.9) and the positive rate number was (0.9±1.8). \u0000 \u0000 \u0000Conclusions \u0000LPD improves the operation quality, reduces intraoperative hemorrhage and accelerates the postoperative recovery. \u0000 \u0000 \u0000Key words: \u0000Laparoscopy; Pancreaticoduodenectomy","PeriodicalId":66425,"journal":{"name":"中华普通外科杂志","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47627270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-25DOI: 10.3760/CMA.J.ISSN.1007-631X.2019.12.002
Xueliang Fu, JianYu Yang, De-Jun Liu, Y. Huo, Wei Liu, Jun-Feng Zhang, R. Hua, Yong-wei Sun
Objective To investigate the prognostic factors of survival for patients with duodenal papilla carcinoma (DPC) after pancreaticoduodenectomy. Methods 98 DPC patients undergoing pancreaticoduodenectomy with follow-up from Jan 2010 to Dec 2017 at Renji Hospital, School of Medicine, Shanghai Jiao Tong University were analyzed retrospectively. Results 80 Cases were followed up. The 1, 3, and 5 year survival rates of 80 patients were 89.9%, 72.4%, and 66.6%, respectively. Univariate analysis showed tumor size, T stage, N stage, TNM stage, tissue differentiation degree were related to postoperative survival(all P<0.05). Multivariate analysis showed that tumor size, N stage, TNM stage, and tissue differentiation degree were independent factors influencing postoperative prognosis(all P<0.05). Conclusions Tumor size, N stage, TNM stage and tumor tissue differentiation degree were independent factors influencing the prognosis of DPC after pancreaticoduodenectomy, suggesting that early diagnosis, early treatment and radical resection were the key to improve the postoperative prognosis of DPC. Key words: Duodenal neoplasms; Pancreaticoduodenectomy; Prognosis
{"title":"Prognostic factors of survival for patients with duodenal papilla carcinoma after pancreaticoduodenectomy","authors":"Xueliang Fu, JianYu Yang, De-Jun Liu, Y. Huo, Wei Liu, Jun-Feng Zhang, R. Hua, Yong-wei Sun","doi":"10.3760/CMA.J.ISSN.1007-631X.2019.12.002","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1007-631X.2019.12.002","url":null,"abstract":"Objective \u0000To investigate the prognostic factors of survival for patients with duodenal papilla carcinoma (DPC) after pancreaticoduodenectomy. \u0000 \u0000 \u0000Methods \u000098 DPC patients undergoing pancreaticoduodenectomy with follow-up from Jan 2010 to Dec 2017 at Renji Hospital, School of Medicine, Shanghai Jiao Tong University were analyzed retrospectively. \u0000 \u0000 \u0000Results \u000080 Cases were followed up. The 1, 3, and 5 year survival rates of 80 patients were 89.9%, 72.4%, and 66.6%, respectively. Univariate analysis showed tumor size, T stage, N stage, TNM stage, tissue differentiation degree were related to postoperative survival(all P<0.05). Multivariate analysis showed that tumor size, N stage, TNM stage, and tissue differentiation degree were independent factors influencing postoperative prognosis(all P<0.05). \u0000 \u0000 \u0000Conclusions \u0000Tumor size, N stage, TNM stage and tumor tissue differentiation degree were independent factors influencing the prognosis of DPC after pancreaticoduodenectomy, suggesting that early diagnosis, early treatment and radical resection were the key to improve the postoperative prognosis of DPC. \u0000 \u0000 \u0000Key words: \u0000Duodenal neoplasms; Pancreaticoduodenectomy; Prognosis","PeriodicalId":66425,"journal":{"name":"中华普通外科杂志","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47559934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective To explore the feasibility and clinical efficacy of serosal muscular layers incision and submucosal layers exfoliation technique in laparoscopic surgery for gastric gastrointestinal stromal tumors(GIST). Methods 28 patients with gastric GIST underwent serosal muscular layers incision and submucosal layers exfoliation technique under laparoscopic surgery. Patients′clinicopathologic characteristics, operative outcomes, postoperative complications, and follow up results were analyzed retrospectively. Results Surgery was successfully completed in all patients, and no one was converted to open surgery.The average operation time was (66±15) min, and the intra operative blood loss was (16±10) ml, the time of passage of gas by anus after operation was (20±10)h, the time starting liquid diet was(2.5±1.6)d, and the length of postoperative hospital stay was (7±3)d. One patient had delayed gastric emptying, one had incisional infection. All the specimen had complete pseudocapsule and negative margin. pathology was all gastric GIST. After a median 22 months followed up, no recurrence or metastasis were found. Conclusion Serosal muscular layers incision and submucosal layers exfoliation under laparoscopic surgery is a safe and feasible procedure for treating gastric GIST. Key words: Gastric gastrointestinal stromal tumors; Laparoscopy; Operative procedures, surgical
{"title":"Serosal and muscular layers incision and use of submucosal layers exfoliation technique in laparoscopic surgery for gastric gastrointestinal stromal tumors","authors":"Xie Jianming, Zhang Moucheng, Yin Yongfang, Zhang Zhiping, Zhou Jiaming, Yan Zhilong","doi":"10.3760/CMA.J.ISSN.1007-631X.2019.11.013","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1007-631X.2019.11.013","url":null,"abstract":"Objective \u0000To explore the feasibility and clinical efficacy of serosal muscular layers incision and submucosal layers exfoliation technique in laparoscopic surgery for gastric gastrointestinal stromal tumors(GIST). \u0000 \u0000 \u0000Methods \u000028 patients with gastric GIST underwent serosal muscular layers incision and submucosal layers exfoliation technique under laparoscopic surgery. Patients′clinicopathologic characteristics, operative outcomes, postoperative complications, and follow up results were analyzed retrospectively. \u0000 \u0000 \u0000Results \u0000Surgery was successfully completed in all patients, and no one was converted to open surgery.The average operation time was (66±15) min, and the intra operative blood loss was (16±10) ml, the time of passage of gas by anus after operation was (20±10)h, the time starting liquid diet was(2.5±1.6)d, and the length of postoperative hospital stay was (7±3)d. One patient had delayed gastric emptying, one had incisional infection. All the specimen had complete pseudocapsule and negative margin. pathology was all gastric GIST. After a median 22 months followed up, no recurrence or metastasis were found. \u0000 \u0000 \u0000Conclusion \u0000Serosal muscular layers incision and submucosal layers exfoliation under laparoscopic surgery is a safe and feasible procedure for treating gastric GIST. \u0000 \u0000 \u0000Key words: \u0000Gastric gastrointestinal stromal tumors; Laparoscopy; Operative procedures, surgical","PeriodicalId":66425,"journal":{"name":"中华普通外科杂志","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49204055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-11-25DOI: 10.3760/CMA.J.ISSN.1007-631X.2019.11.009
Xin Jia, W. Guo, Xiao-ping Liu, J. Xiong, XiaoHui Ma, Hongpeng Zhang, Yong-Le Xu
Objective To evaluate the safety and efficacy of the drug coated balloon(DCB) for complex TASC C/D superficial femora-popliteal artery diseases. Methods Patency, target lesion revascularization (TLR) rate, clinical improvement and safety endpoints of femora-popliteal lesions in 68 patients from PLA General Hospital treated with DCB were retrospectively analyzed from June 2016 to June 2018. The mean age of the patients were (72.7±13.2) years old. Rutherford categories were from 2 to 5, and ABI baseline were 0.56±0.22. Results There were 76 limbs treated by DCB in total in this study. Mean lesion length was (26.7±15.3) cm. 73.6% of lesions were totally occluded, 26.4% were of stenosis and 61.8% were highly calcified. Stent implantation was performed in 36.8% cases. Kaplan Meier estimates of primary patency were 74.2%±7.6% and 67.7%±6.4% at 1 and 2 years, respectively, whereas freedom from TLR was 81.4%±5.1% and 73.6%±5.4%. ABI were 0.83±0.16 at 1 year, and 0.79±0.24 at 2 years. Major amputation rate was 2.9% and mortality rate was 2.9% and 4.4% at 1 year and 2 years respectively. Diabetes, highly calcification, renal insufficiency and re-stenotic lesions were identified as predictors of restenosis. Conclusions DCB are safe and effective in delaying restenosis in complex TASC C/D superficial femora-popliteal artery disease as found by midterm follow-up. Key words: Peripheral arterial diseases; Arteries; Drug coated balloon
{"title":"The midterm result of drug coated balloon with paclitaxel for the treatment of TASC C/D superficial femora-popliteal artery disease","authors":"Xin Jia, W. Guo, Xiao-ping Liu, J. Xiong, XiaoHui Ma, Hongpeng Zhang, Yong-Le Xu","doi":"10.3760/CMA.J.ISSN.1007-631X.2019.11.009","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1007-631X.2019.11.009","url":null,"abstract":"Objective \u0000To evaluate the safety and efficacy of the drug coated balloon(DCB) for complex TASC C/D superficial femora-popliteal artery diseases. \u0000 \u0000 \u0000Methods \u0000Patency, target lesion revascularization (TLR) rate, clinical improvement and safety endpoints of femora-popliteal lesions in 68 patients from PLA General Hospital treated with DCB were retrospectively analyzed from June 2016 to June 2018. The mean age of the patients were (72.7±13.2) years old. Rutherford categories were from 2 to 5, and ABI baseline were 0.56±0.22. \u0000 \u0000 \u0000Results \u0000There were 76 limbs treated by DCB in total in this study. Mean lesion length was (26.7±15.3) cm. 73.6% of lesions were totally occluded, 26.4% were of stenosis and 61.8% were highly calcified. Stent implantation was performed in 36.8% cases. Kaplan Meier estimates of primary patency were 74.2%±7.6% and 67.7%±6.4% at 1 and 2 years, respectively, whereas freedom from TLR was 81.4%±5.1% and 73.6%±5.4%. ABI were 0.83±0.16 at 1 year, and 0.79±0.24 at 2 years. Major amputation rate was 2.9% and mortality rate was 2.9% and 4.4% at 1 year and 2 years respectively. Diabetes, highly calcification, renal insufficiency and re-stenotic lesions were identified as predictors of restenosis. \u0000 \u0000 \u0000Conclusions \u0000DCB are safe and effective in delaying restenosis in complex TASC C/D superficial femora-popliteal artery disease as found by midterm follow-up. \u0000 \u0000 \u0000Key words: \u0000Peripheral arterial diseases; Arteries; Drug coated balloon","PeriodicalId":66425,"journal":{"name":"中华普通外科杂志","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44500694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-11-25DOI: 10.3760/CMA.J.ISSN.1007-631X.2019.11.014
Baoxiang Chen, K. Sun, Yuntian Hong, Bo Liu, Xueqiao Yu, Zhao Ding, Qun Qian, Congqing Jiang, Qiu-ya Zhao, Mei-fang Huang, M. Ye, Tong Yin, Huichu Ye
Objective To investigate the sexual function, urinary function and quality of life in patients of ulcerative colitis(UC) and familial adenomatous polyposis(FAP) after total proctocolectomy and ileal pouch anal anastomosis (IPAA). Methods The clinical data of patients with UC and FAP undergoing IPAA at Zhongnan Hospital of Wuhan University from Jan 2006 to Sep 2018 were reviewed , postoperative sexual function, urinary function, and long-term quality of life were assessed. Results There were 45 patients with median age of 35 years , median follow-up time of 31 months. 18 were UC, 27 were FAP, 5 did 1-stage surgery, 37 did 2-stage surgery, 3 for 3-stage surgery, 13 underwent open surgery, and 32 underwent laparoscopic surgery. 7 patients suffered sexual dysfunction after IPAA, and there was no statistical difference between male and female (P=0.992), UC and FAP (P=0.153), 1-stage , 2-stage , and 3-stage surgery (P=0.363) , with statistically significant difference between the open group and the laparoscopic group (P=0.025). 6 patients complicated with urinary dysfunction after IPAA , and there was no statistical difference between male and female (P=0.562), UC and FAP (P=0.325), 1-stage, 2-stage, and 3-stage surgery (P=0.286) , with statistically significant difference between the open group and the laparoscopic group (P=0.007). The Cleveland Global Quality of Life (CGQL) score after IPAA was 0.696±0.085. There were no statistical difference on CGQL scores in males and females (P=0.635), UC and FAP (P=0.664), 1-stage, 2-stage, and 3-stage (P>0.05), open group and laparoscopic group (P=0.205), postoperative long-term QOL was significantly associated only with age at the time of surgery (P=0.001). Conclusions Compared with open surgery, laparoscopic TPC-IPAA patients had better postoperative sexual function and urination function. Key words: Sexual dysfunction, physiological; Urination disorders; Anastomosis, surgical
{"title":"Sexual function, urinary function and quality of life in patients after total proctocolectomy and ileal pouch anal anastomosis","authors":"Baoxiang Chen, K. Sun, Yuntian Hong, Bo Liu, Xueqiao Yu, Zhao Ding, Qun Qian, Congqing Jiang, Qiu-ya Zhao, Mei-fang Huang, M. Ye, Tong Yin, Huichu Ye","doi":"10.3760/CMA.J.ISSN.1007-631X.2019.11.014","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1007-631X.2019.11.014","url":null,"abstract":"Objective \u0000To investigate the sexual function, urinary function and quality of life in patients of ulcerative colitis(UC) and familial adenomatous polyposis(FAP) after total proctocolectomy and ileal pouch anal anastomosis (IPAA). \u0000 \u0000 \u0000Methods \u0000The clinical data of patients with UC and FAP undergoing IPAA at Zhongnan Hospital of Wuhan University from Jan 2006 to Sep 2018 were reviewed , postoperative sexual function, urinary function, and long-term quality of life were assessed. \u0000 \u0000 \u0000Results \u0000There were 45 patients with median age of 35 years , median follow-up time of 31 months. 18 were UC, 27 were FAP, 5 did 1-stage surgery, 37 did 2-stage surgery, 3 for 3-stage surgery, 13 underwent open surgery, and 32 underwent laparoscopic surgery. 7 patients suffered sexual dysfunction after IPAA, and there was no statistical difference between male and female (P=0.992), UC and FAP (P=0.153), 1-stage , 2-stage , and 3-stage surgery (P=0.363) , with statistically significant difference between the open group and the laparoscopic group (P=0.025). 6 patients complicated with urinary dysfunction after IPAA , and there was no statistical difference between male and female (P=0.562), UC and FAP (P=0.325), 1-stage, 2-stage, and 3-stage surgery (P=0.286) , with statistically significant difference between the open group and the laparoscopic group (P=0.007). The Cleveland Global Quality of Life (CGQL) score after IPAA was 0.696±0.085. There were no statistical difference on CGQL scores in males and females (P=0.635), UC and FAP (P=0.664), 1-stage, 2-stage, and 3-stage (P>0.05), open group and laparoscopic group (P=0.205), postoperative long-term QOL was significantly associated only with age at the time of surgery (P=0.001). \u0000 \u0000 \u0000Conclusions \u0000Compared with open surgery, laparoscopic TPC-IPAA patients had better postoperative sexual function and urination function. \u0000 \u0000 \u0000Key words: \u0000Sexual dysfunction, physiological; Urination disorders; Anastomosis, surgical","PeriodicalId":66425,"journal":{"name":"中华普通外科杂志","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46399239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-11-25DOI: 10.3760/CMA.J.ISSN.1007-631X.2019.11.008
Jiongdi Lu, Yi-Xuan Dıng, F. Cao, Fei Lı
Objective To survey the bacterial spectrum and drug sensitivity in patients with necrotizing pancreatitis (NP) complicating with extra-pancreatic infection(EPI). Methods The clinical data of 79 NP with EPI patients from Jan 1, 2016 to Dec 31, 2018 were retrospectively analyzed. The strain identification and drug sensitivity test of positive specimens were statistically analyzed. Results A total of 219 strains of pathogenic bacteria were isolated, including 106(48.4%) gram-negative bacteria, 69(31.5%) gram-positive bacteria and 44(20.1%) fungi. The common pathogenic bacteria were Pseudomonas aeruginosa (10.1%), Staphylococcus epidermidis (9.1%) and Acinetobacter baumannii (9.1%). The resistance of common extrapancreatic pathogenic bacteria to penicillin and first and second generation cephalosporins was common. Conclusions The pathogenic bacteria of NP complicated with EPI were mainly Gram-negative bacteria, and the common sites of extra-pancreatic infection were bacteremia and respiratory tract. The third, fourth generation cephalosporins or carbapenems can be used empirically. Key words: Pancreatitis, acute necrotizing; Infection; Pathogenic bacteria; Drug sensitivity test
{"title":"Bacterial spectrum and drug sensitivity analysis in necrotizing pancreatitis with extra-pancreatic infection","authors":"Jiongdi Lu, Yi-Xuan Dıng, F. Cao, Fei Lı","doi":"10.3760/CMA.J.ISSN.1007-631X.2019.11.008","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1007-631X.2019.11.008","url":null,"abstract":"Objective \u0000To survey the bacterial spectrum and drug sensitivity in patients with necrotizing pancreatitis (NP) complicating with extra-pancreatic infection(EPI). \u0000 \u0000 \u0000Methods \u0000The clinical data of 79 NP with EPI patients from Jan 1, 2016 to Dec 31, 2018 were retrospectively analyzed. The strain identification and drug sensitivity test of positive specimens were statistically analyzed. \u0000 \u0000 \u0000Results \u0000A total of 219 strains of pathogenic bacteria were isolated, including 106(48.4%) gram-negative bacteria, 69(31.5%) gram-positive bacteria and 44(20.1%) fungi. The common pathogenic bacteria were Pseudomonas aeruginosa (10.1%), Staphylococcus epidermidis (9.1%) and Acinetobacter baumannii (9.1%). The resistance of common extrapancreatic pathogenic bacteria to penicillin and first and second generation cephalosporins was common. \u0000 \u0000 \u0000Conclusions \u0000The pathogenic bacteria of NP complicated with EPI were mainly Gram-negative bacteria, and the common sites of extra-pancreatic infection were bacteremia and respiratory tract. The third, fourth generation cephalosporins or carbapenems can be used empirically. \u0000 \u0000 \u0000Key words: \u0000Pancreatitis, acute necrotizing; Infection; Pathogenic bacteria; Drug sensitivity test","PeriodicalId":66425,"journal":{"name":"中华普通外科杂志","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46653487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-11-25DOI: 10.3760/CMA.J.ISSN.1007-631X.2019.11.010
Han Tonglei, Yudong Sun, Wei Xiaolong, Zhu Jiang, Xie Yongfu, W. Shiying, Bingjie Zhao, Zhiqing Zhao
Objective To investigate the relationship between the maximum thickness of carotid atherosclerotic plaque and the incidence of complications after carotid stenting in patients with severe carotid stenosis. Methods The clinical data of 85 patients with severe carotid stenosis undergoing CAS were analyzed. The maximum thickness of carotid plaque was evaluated according to ultrasound imaging data.Patients were divided into two groups according to the optimal threshold value: 0.435 mm, which calculated in the ROC curve of plaque thickness. The incidence of complications within two years after CAS was analyzed. Results 85 patients were followed up for 2 years: restenosis occurred in 12 cases, the incidence rate was 14.1%, which was significantly correlated with the maximum thickness of atherosclerotic plaque(P=0.002). Postoperative restenosis occurred in 2 cases (3.70%) in group A and 10 cases (32.26%) in group B(P<0.001); Three cases (9.68%) suffered from relapsing cerebral infarction in group B compared to none in group A(P=0.020). Conclusion With the carotid plaque growing thicker, the incidence of restenosis after CAS in patients with carotid stenosis increases. Especially in patients whose maximum plaque thickness is more than 0.435 mm, the incidence of restenosis postoperative increases remarkably. Key words: Atherosclerosis; Complications; Maximum thickness of plaque; Carotid artery stenting
{"title":"Correlation between maximum thickness of carotid plaque and postoperative complications of CAS in patients with severe carotid stenosis","authors":"Han Tonglei, Yudong Sun, Wei Xiaolong, Zhu Jiang, Xie Yongfu, W. Shiying, Bingjie Zhao, Zhiqing Zhao","doi":"10.3760/CMA.J.ISSN.1007-631X.2019.11.010","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1007-631X.2019.11.010","url":null,"abstract":"Objective \u0000To investigate the relationship between the maximum thickness of carotid atherosclerotic plaque and the incidence of complications after carotid stenting in patients with severe carotid stenosis. \u0000 \u0000 \u0000Methods \u0000The clinical data of 85 patients with severe carotid stenosis undergoing CAS were analyzed. The maximum thickness of carotid plaque was evaluated according to ultrasound imaging data.Patients were divided into two groups according to the optimal threshold value: 0.435 mm, which calculated in the ROC curve of plaque thickness. The incidence of complications within two years after CAS was analyzed. \u0000 \u0000 \u0000Results \u000085 patients were followed up for 2 years: restenosis occurred in 12 cases, the incidence rate was 14.1%, which was significantly correlated with the maximum thickness of atherosclerotic plaque(P=0.002). Postoperative restenosis occurred in 2 cases (3.70%) in group A and 10 cases (32.26%) in group B(P<0.001); Three cases (9.68%) suffered from relapsing cerebral infarction in group B compared to none in group A(P=0.020). \u0000 \u0000 \u0000Conclusion \u0000With the carotid plaque growing thicker, the incidence of restenosis after CAS in patients with carotid stenosis increases. Especially in patients whose maximum plaque thickness is more than 0.435 mm, the incidence of restenosis postoperative increases remarkably. \u0000 \u0000 \u0000Key words: \u0000Atherosclerosis; Complications; Maximum thickness of plaque; Carotid artery stenting","PeriodicalId":66425,"journal":{"name":"中华普通外科杂志","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42075538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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