血液科学(英文)最新文献

英文中文

Beyond the horizon: the newly found sinner disturbing mesenchymal stromal niche. 地平线之外:新发现的罪人干扰间充质间质壁龛。

Q3 HEMATOLOGY

血液科学(英文)

Pub Date : 2022-07-01 DOI: 10.1097/BS9.0000000000000119

Xi Zhang

Hematopoietic stem-cell transplantation (HSCT) is an important, potentially curative therapeutic option for hema-tological malignancies. However, poor and slow hematopoi- etic reconstitution remains a significant complication, which is correlated with abnormal hematopoietic stem-cell (HSC) func- tion. The maintenance and the preservation of HSC functional properties are supported by a highly specialized microenviron- ment within the bone marrow (BM), in which BM-derived mesenchymal stem cells (BMSCs) serve as the essential structural and functional basis for constituting the BM microenviron-ment. Damage, such as that due to chemotherapy, radiother- apy or inflammation, delays hematopoietic recovery or causes hematopoiesis dysfunction or failure, seriously affecting HSCT efficacy. 1 The key to remodeling and repairing the BM micro-environment lies in the repair of the niche structure by cellular therapies which include BMSCs. Research has increasingly confirmed that the most crucial functions of BMSCs are to main- tain the turnover of the BM stroma and skeletal tissues and to provide critical hematopoietic support. 2 However, the underly-ing mechanisms that regulate these different functions are not well known. In the recent BLOOD publication, the Dr. Zhao and Dr. Jiang group revealed that the retinoic acid-inducible gene I (RIG-I) plays a substantial role in regulating the stromal niche for hematopoietic reconstitution. 3 All-trans retinoic acid (ATRA) and inflammation stress upregulated RIG-I expres- sion, thus damaging the clonogenicity, the bone-forming ability of BMSCs and the supporting function in the stromal niche; mechanistically, this is achieved by suppressing the antioxidant impact of nuclear

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引用次数: 0

Pharmacological targeting EZH2 to modulate chronic graft-versus-host disease. 药物靶向EZH2调节慢性移植物抗宿主病。

Q3 HEMATOLOGY

血液科学(英文)

Pub Date : 2022-07-01 DOI: 10.1097/BS9.0000000000000125

Ying Wang

In a recent issue of Blood ( Blood 139, 2022), Zaiken

引用次数: 0

Comprehensive view on genetic features, therapeutic modalities and prognostic models in adult T-cell lymphoblastic lymphoma. 成人t细胞淋巴母细胞淋巴瘤的遗传特征、治疗方式和预后模式的综合观点。

Q3 HEMATOLOGY

血液科学(英文)

Pub Date : 2022-07-01 DOI: 10.1097/BS9.0000000000000114

Qihua Zou, Shuyun Ma, Xiaopeng Tian, Qingqing Cai

Adult T-cell lymphoblastic lymphoma (T-LBL) is a rare and aggressive subtype of non-Hodgkin's lymphoma that differs from pediatric T-LBL and has a worse prognosis. Due to its rarity, little is known about the genetic and molecular characteristics, optimal treatment modalities, and prognostic factors of adult T-LBL. Therefore, we summarized the existing studies to comprehensively discuss the above issues in this review. Genetic mutations of NOTCH1/FBXW7, PTEN, RAS, and KMT2D, together with abnormal activation of signaling pathways, such as the JAK-STAT signaling pathway were described. We also discussed the therapeutic modalities. Once diagnosed, adult T-LBL patients should receive intensive or pediatric acute lymphoblastic leukemia regimen and central nervous system prophylaxis as soon as possible, and cranial radiation-free protocols are appropriate. Mediastinal radiotherapy improves clinical outcomes, but adverse events are of concern. Hematopoietic stem cell transplantation may be considered for adult T-LBL patients with high-risk factors or those with relapsed/refractory disease. Besides, several novel prognostic models have been constructed, such as the 5-miRNAs-based classifier, 11-gene-based classifier, and 4-CpG-based classifier, which have presented significant prognostic value in adult T-LBL.

成人t细胞淋巴母细胞淋巴瘤(T-LBL)是一种罕见的侵袭性非霍奇金淋巴瘤亚型，与儿童T-LBL不同，预后较差。由于其罕见性，对成人T-LBL的遗传和分子特征、最佳治疗方式和预后因素知之甚少。因此，我们对已有的研究进行总结，对上述问题进行全面探讨。NOTCH1/FBXW7、PTEN、RAS和KMT2D基因突变，以及JAK-STAT信号通路异常激活。我们还讨论了治疗方式。一旦确诊，成人T-LBL患者应尽快接受强化治疗或儿童急性淋巴细胞白血病治疗方案和中枢神经系统预防，并适当采用颅脑无辐射治疗方案。纵隔放射治疗改善了临床结果，但不良事件令人担忧。有高危因素的成人T-LBL患者或复发/难治性疾病患者可考虑进行造血干细胞移植。此外，基于5- mirnas的分类器、基于11-基因的分类器、基于4- cpg的分类器等新型预后模型的构建，对成人T-LBL具有重要的预后价值。

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引用次数: 1

Small noncoding RNAs play superior roles in maintaining hematopoietic stem cell homeostasis. 小的非编码rna在维持造血干细胞稳态中发挥着优越的作用。

Q3 HEMATOLOGY

血液科学(英文)

Pub Date : 2022-07-01 DOI: 10.1097/BS9.0000000000000123

Hui Wang, Wenchang Qian, Yingli Han, Pengxu Qian

The maintenance of the mammalian blood system depends on hematopoietic stem cells (HSCs), which are a rare class of adult stem cells with self-renewal and multilineage differentiation capacities. The homeostasis of hematopoietic stem cells is finely tuned by a variety of endogenous and exogenous regulatory factors, and disrupted balance will lead to hematological diseases including leukemia and anemia. Recently, emerging studies have illustrated the cellular and molecular mechanisms underlying the regulation of HSC homeostasis. Particularly, the rapid development of second-generation sequencing technologies has uncovered that many small noncoding RNAs (ncRNAs) are highly expressed in HSCs, including snoRNAs, miRNAs, tsRNAs, circular RNAs, etc. In this study, we will summarize the essential roles and regulatory mechanisms of these small ncRNAs in maintaining HSC homeostasis. Overall, this review provides up-to-date information in the regulation of HSC homeostasis by small ncRNAs, which sheds light into the development of therapeutic strategies against hematopoietic malignancies.

哺乳动物血液系统的维持依赖于造血干细胞(hsc)，这是一类罕见的具有自我更新和多谱系分化能力的成体干细胞。造血干细胞的体内平衡受到多种内源性和外源性调节因子的精细调节，平衡被破坏会导致包括白血病和贫血在内的血液系统疾病。最近，新兴的研究已经阐明了HSC稳态调节的细胞和分子机制。特别是第二代测序技术的快速发展，揭示了许多小的非编码rna (ncRNAs)在造血干细胞中高表达，包括snoRNAs、miRNAs、tsRNAs、环状rna等。在本研究中，我们将总结这些小ncrna在维持HSC稳态中的重要作用和调控机制。总的来说，这篇综述提供了小ncrna调控HSC稳态的最新信息，这为针对造血恶性肿瘤的治疗策略的发展提供了线索。

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引用次数: 0

An old player, the right niche. 老玩家，合适的利基市场。

Q3 HEMATOLOGY

血液科学(英文)

Pub Date : 2022-04-01 DOI: 10.1097/BS9.0000000000000105

Cheng Cheng Zhang

The cellular and molecular components of the niche for hematopoietic stem cells (HSCs) are still not well de ﬁ ned. Angiopoietin-like proteins (Angptls) are a group of secreted glycoproteins that have been reported to play various roles, including the regulation of HSC activity. 1 Speci ﬁ cally, Angptl2, a member of the Angptl family, was demonstrated to support HSC stemness through binding to inhibitory receptors. 2 Angptl2 has also been shown to support HSC activity in exosomes. 3 However, whether and how Angptl2 regulates HSC activities in the HSC niche were still unknown. Yu et al used an elegant approach to study these questions. 1 Based on the expression pattern of Angptl2 in bone marrow, several conditional knockout (KO) mice were generated to deplete Angptl2 from endothelial, mesenchymal stromal cells, megakaryocytes, and HSCs. Using a number of functional assays, including reconstitution analysis, ﬂ ow cytometry, and immuno ﬂ uorescence microscopy, the authors discovered that only endothelial cell-derived Angptl2 but not Angptl2 from other niche cell types supported the repopulation capacity, quiescent status, and niche localization of HSCs. They further demonstrated that Angptl2 enhances peroxisome-proliferator-activated receptor D expression to transactivate G0s2 and sustain the perinuclear localization of nucleolin that prevents HSCs from entering the cell cycle. study HSCs

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引用次数: 0

Erratum: Tcf12 balances the reconstitution and differentiation capacity of hematopoietic stem cell. Tcf12平衡造血干细胞的重构和分化能力

IF 1.5 Q3 HEMATOLOGY

血液科学(英文)

Pub Date : 2022-03-08 eCollection Date: 2021-07-01 DOI: 10.1097/BS9.0000000000000087

[This corrects the article DOI: 10.1097/BS9.0000000000000059.].

[这更正了文章DOI: 10.1097/BS9.0000000000000059.]。

引用次数: 0

Erratum: Loss of Tet2 affects platelet function but not coagulation in mice. Tet2缺失影响小鼠血小板功能，但不影响凝血

IF 1.5 Q3 HEMATOLOGY

血液科学(英文)

Pub Date : 2022-03-08 eCollection Date: 2021-07-01 DOI: 10.1097/BS9.0000000000000085

[This corrects the article DOI: 10.1097/BS9.0000000000000055.].

[这更正了文章DOI:10.1097/BS90000000000000055.]。

引用次数: 0

Erratum: GSDME maintains hematopoietic stem cells by balancing pyroptosis and apoptosis. GSDME通过平衡pyroptosis和细胞凋亡维持造血干细胞

IF 1.5 Q3 HEMATOLOGY

血液科学(英文)

Pub Date : 2022-03-08 eCollection Date: 2021-07-01 DOI: 10.1097/BS9.0000000000000088

[This corrects the article DOI: 10.1097/BS9.0000000000000064.].

[这更正了文章DOI:10.1097/BS90000000000000064.]。

引用次数: 0

Erratum: BECN1 modulates hematopoietic stem cells by targeting Caspase-3-GSDME-mediated pyroptosis. BECN1通过靶向caspase -3- gsdme介导的焦亡来调节造血干细胞

IF 1.5 Q3 HEMATOLOGY

血液科学(英文)

Pub Date : 2022-03-08 eCollection Date: 2021-07-01 DOI: 10.1097/BS9.0000000000000084

[This corrects the article DOI: 10.1097/BS9.0000000000000051.].

[这更正了文章DOI: 10.1097/BS9.0000000000000051.]。

引用次数: 0

Erratum: ALKBH3 is dispensable in maintaining hematopoietic stem cells but forced ALKBH3 rectified the differentiation skewing of aged hematopoietic stem cells. ALKBH3在维持造血干细胞方面是可有可无的，但强制ALKBH3纠正了衰老造血干细胞的分化偏斜

IF 1.5 Q3 HEMATOLOGY

血液科学(英文)

Pub Date : 2022-03-08 eCollection Date: 2021-07-01 DOI: 10.1097/BS9.0000000000000086

[This corrects the article DOI: 10.1097/BS9.0000000000000057.].

[这更正了文章DOI: 10.1097/BS9.0000000000000057.]。

引用次数: 0

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