Pub Date : 2022-05-17eCollection Date: 2022-04-01DOI: 10.1097/BS9.0000000000000111
Guangji Zhang, Yang Song, Li Wan, Kaiqi Liu, Shaowei Qiu, Jianxiang Wang, Yingchang Mi
Introduction: Acute promyelocytic leukemia (APL) is mostly due to the chromosome translocation t (15; 17) (q22; q12), leading to the formation of PML-RARA fusion protein. Some patients carried rare translocation involving RARA gene, who were called variant APL caused by RAR family (RARA, RARB, and RARG) and partner genes. STAT5b-RARA was a rare type of molecular genetic abnormality with unfavorable prognosis which have been reported in only 18 cases in variant APL. Knowledge of STAT5b-RARA (+) APL treatment is still limited.
Case report: We presented a 38-year-old female variant APL case, who was STAT5b-RARA positive detected by reverse transcription polymerase chain reaction. The patient failed to respond after four-drug combined induction chemotherapy: idarubicin, cytarabine, all trans retinoic acid, and arsenic trioxide (As2O3). Then, the patient was re-induced with azacytidine, but still failed to achieve complete remission (CR). Next, she was treated with Venetoclax combining with homoharringtonine and cytarabine as the salvage therapy and achieved CR. Later, the patient received hematopoietic stem cell transplantation after 4 cycles of consolidation therapy.
Conclusion: Venetoclax combining with homoharringtonine and cytarabine has been used as the salvage therapy in the STAT5b-RARA positive APL successfully.
{"title":"Treatment of STAT5b-RARA positive acute promyelocytic leukemia by Venetoclax combining with homoharringtonine, cytarabine: A case report and literature review.","authors":"Guangji Zhang, Yang Song, Li Wan, Kaiqi Liu, Shaowei Qiu, Jianxiang Wang, Yingchang Mi","doi":"10.1097/BS9.0000000000000111","DOIUrl":"https://doi.org/10.1097/BS9.0000000000000111","url":null,"abstract":"<p><strong>Introduction: </strong>Acute promyelocytic leukemia (APL) is mostly due to the chromosome translocation t (15; 17) (q22; q12), leading to the formation of <i>PML-RARA</i> fusion protein. Some patients carried rare translocation involving RARA gene, who were called variant APL caused by RAR family (RARA, RARB, and RARG) and partner genes. <i>STAT5b-RARA</i> was a rare type of molecular genetic abnormality with unfavorable prognosis which have been reported in only 18 cases in variant APL. Knowledge of <i>STAT5b-RARA</i> (+) APL treatment is still limited.</p><p><strong>Case report: </strong>We presented a 38-year-old female variant APL case, who was <i>STAT5b-RARA</i> positive detected by reverse transcription polymerase chain reaction. The patient failed to respond after four-drug combined induction chemotherapy: idarubicin, cytarabine, all trans retinoic acid, and arsenic trioxide (As<sub>2</sub>O<sub>3</sub>). Then, the patient was re-induced with azacytidine, but still failed to achieve complete remission (CR). Next, she was treated with Venetoclax combining with homoharringtonine and cytarabine as the salvage therapy and achieved CR. Later, the patient received hematopoietic stem cell transplantation after 4 cycles of consolidation therapy.</p><p><strong>Conclusion: </strong>Venetoclax combining with homoharringtonine and cytarabine has been used as the salvage therapy in the <i>STAT5b-RARA</i> positive APL successfully.</p>","PeriodicalId":67343,"journal":{"name":"血液科学(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b3/b3/bls-4-93.PMC9362865.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40715319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-01DOI: 10.1097/BS9.0000000000000105
Cheng Cheng Zhang
The cellular and molecular components of the niche for hematopoietic stem cells (HSCs) are still not well de fi ned. Angiopoietin-like proteins (Angptls) are a group of secreted glycoproteins that have been reported to play various roles, including the regulation of HSC activity. 1 Speci fi cally, Angptl2, a member of the Angptl family, was demonstrated to support HSC stemness through binding to inhibitory receptors. 2 Angptl2 has also been shown to support HSC activity in exosomes. 3 However, whether and how Angptl2 regulates HSC activities in the HSC niche were still unknown. Yu et al used an elegant approach to study these questions. 1 Based on the expression pattern of Angptl2 in bone marrow, several conditional knockout (KO) mice were generated to deplete Angptl2 from endothelial, mesenchymal stromal cells, megakaryocytes, and HSCs. Using a number of functional assays, including reconstitution analysis, fl ow cytometry, and immuno fl uorescence microscopy, the authors discovered that only endothelial cell-derived Angptl2 but not Angptl2 from other niche cell types supported the repopulation capacity, quiescent status, and niche localization of HSCs. They further demonstrated that Angptl2 enhances peroxisome-proliferator-activated receptor D expression to transactivate G0s2 and sustain the perinuclear localization of nucleolin that prevents HSCs from entering the cell cycle. study HSCs
{"title":"An old player, the right niche.","authors":"Cheng Cheng Zhang","doi":"10.1097/BS9.0000000000000105","DOIUrl":"https://doi.org/10.1097/BS9.0000000000000105","url":null,"abstract":"The cellular and molecular components of the niche for hematopoietic stem cells (HSCs) are still not well de fi ned. Angiopoietin-like proteins (Angptls) are a group of secreted glycoproteins that have been reported to play various roles, including the regulation of HSC activity. 1 Speci fi cally, Angptl2, a member of the Angptl family, was demonstrated to support HSC stemness through binding to inhibitory receptors. 2 Angptl2 has also been shown to support HSC activity in exosomes. 3 However, whether and how Angptl2 regulates HSC activities in the HSC niche were still unknown. Yu et al used an elegant approach to study these questions. 1 Based on the expression pattern of Angptl2 in bone marrow, several conditional knockout (KO) mice were generated to deplete Angptl2 from endothelial, mesenchymal stromal cells, megakaryocytes, and HSCs. Using a number of functional assays, including reconstitution analysis, fl ow cytometry, and immuno fl uorescence microscopy, the authors discovered that only endothelial cell-derived Angptl2 but not Angptl2 from other niche cell types supported the repopulation capacity, quiescent status, and niche localization of HSCs. They further demonstrated that Angptl2 enhances peroxisome-proliferator-activated receptor D expression to transactivate G0s2 and sustain the perinuclear localization of nucleolin that prevents HSCs from entering the cell cycle. study HSCs","PeriodicalId":67343,"journal":{"name":"血液科学(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e3/fd/bls-4-99.PMC9354721.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10798013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-08eCollection Date: 2021-07-01DOI: 10.1097/BS9.0000000000000087
[This corrects the article DOI: 10.1097/BS9.0000000000000059.].
[这更正了文章DOI: 10.1097/BS9.0000000000000059.]。
{"title":"Erratum: Tcf12 balances the reconstitution and differentiation capacity of hematopoietic stem cell.","authors":"","doi":"10.1097/BS9.0000000000000087","DOIUrl":"10.1097/BS9.0000000000000087","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1097/BS9.0000000000000059.].</p>","PeriodicalId":67343,"journal":{"name":"血液科学(英文)","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2022-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8974933/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42369757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-08eCollection Date: 2021-07-01DOI: 10.1097/BS9.0000000000000085
[This corrects the article DOI: 10.1097/BS9.0000000000000055.].
[这更正了文章DOI:10.1097/BS90000000000000055.]。
{"title":"Erratum: Loss of Tet2 affects platelet function but not coagulation in mice.","authors":"","doi":"10.1097/BS9.0000000000000085","DOIUrl":"10.1097/BS9.0000000000000085","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1097/BS9.0000000000000055.].</p>","PeriodicalId":67343,"journal":{"name":"血液科学(英文)","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2022-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8974943/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42748213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-08eCollection Date: 2021-07-01DOI: 10.1097/BS9.0000000000000086
[This corrects the article DOI: 10.1097/BS9.0000000000000057.].
[这更正了文章DOI: 10.1097/BS9.0000000000000057.]。
{"title":"Erratum: ALKBH3 is dispensable in maintaining hematopoietic stem cells but forced ALKBH3 rectified the differentiation skewing of aged hematopoietic stem cells.","authors":"","doi":"10.1097/BS9.0000000000000086","DOIUrl":"10.1097/BS9.0000000000000086","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1097/BS9.0000000000000057.].</p>","PeriodicalId":67343,"journal":{"name":"血液科学(英文)","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2022-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8974893/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48851399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-08eCollection Date: 2021-07-01DOI: 10.1097/BS9.0000000000000080
[This corrects the article DOI: 10.1097/BS9.0000000000000002.].
[这更正了文章DOI: 10.1097/BS9.0000000000000002.]。
{"title":"Erratum: IL-12 supports in vitro self-renewal of LT HSC.","authors":"","doi":"10.1097/BS9.0000000000000080","DOIUrl":"10.1097/BS9.0000000000000080","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1097/BS9.0000000000000002.].</p>","PeriodicalId":67343,"journal":{"name":"血液科学(英文)","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2022-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8974935/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46408228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-08eCollection Date: 2021-07-01DOI: 10.1097/BS9.0000000000000081
[This corrects the article DOI: 10.1097/BS9.0000000000000019.].
[这更正了文章DOI:10.1097/BS90000000000000019.]。
{"title":"Erratum: A chemotaxis model to explain WHIM neutrophil accumulation in the bone marrow.","authors":"","doi":"10.1097/BS9.0000000000000081","DOIUrl":"10.1097/BS9.0000000000000081","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1097/BS9.0000000000000019.].</p>","PeriodicalId":67343,"journal":{"name":"血液科学(英文)","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2022-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8974996/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48218383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-08eCollection Date: 2021-07-01DOI: 10.1097/BS9.0000000000000083
[This corrects the article DOI: 10.1097/BS9.0000000000000049.].
[这更正了文章DOI:10.1097/BS90000000000000049.]。
{"title":"Erratum: Two-step protocol for regeneration of immunocompetent T cells from mouse pluripotent stem cells.","authors":"","doi":"10.1097/BS9.0000000000000083","DOIUrl":"10.1097/BS9.0000000000000083","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1097/BS9.0000000000000049.].</p>","PeriodicalId":67343,"journal":{"name":"血液科学(英文)","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2022-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8974901/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42615180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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