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2019 IEEE International Ultrasonics Symposium (IUS)最新文献

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Regulating the differentiation of PC12 by acoustic fluid stimulation 声波流体刺激对PC12分化的调节作用
Pub Date : 2019-10-01 DOI: 10.1109/ULTSYM.2019.8926311
Shan He, W. Pang, X. Duan, Yanyan Wang
Regulating the differentiation and regeneration of nerve cells has been proved effective for treating neurological disorders diseases. Although there have been several studies related to neuromodulation, these studies have suffered from invasiveness or low spatial resolution. Herein, a hypersound acoustic stimulation on nerve cells was explored and the results demonstrated this novel method had powerful effect on targeted nerve cell regulation. A bulk acoustic wave resonator fabricated with MEMS process was used to generate hypersound. The acoustic fluid (AF) effect was produced with mechanical pressure when hypersound transmitted with attention in the solution. Results indicated that exposing PC12 cells to AF stimulation, small protrusions would appear within 10 minutes. And differentiation ratio of the AF stimulated cells was 16% higher than that of cells cultured with nerve growth factor (NGF). This original and effective method is compatible with conventional cell culture and had potential in single nerve cells regulation.
调节神经细胞的分化和再生已被证明是治疗神经系统疾病的有效方法。虽然已经有一些与神经调节相关的研究,但这些研究存在侵入性或低空间分辨率的问题。本研究探索了一种超声声刺激神经细胞的方法,结果表明这种新方法对神经细胞的靶向调节有强大的作用。采用MEMS工艺制作体声波谐振器,产生超声。当超声在溶液中集中传播时,在机械压力作用下产生声流体效应。结果表明,在AF刺激下,PC12细胞在10分钟内出现小突起。与神经生长因子(NGF)培养的细胞相比,AF刺激的细胞分化率提高16%。这种新颖有效的方法与传统的细胞培养方法兼容,在单个神经细胞的调节中具有潜力。
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引用次数: 1
Non-Contrast Perfusion Detection with ARFI Variance of Acceleration (VoA) Imaging: Phantom and In Vivo Results 非对比灌注检测与ARFI加速度方差(VoA)成像:幻体和体内结果
Pub Date : 2019-10-01 DOI: 10.1109/ULTSYM.2019.8926231
R. Varadarajan, Gabriela Torres, M. Hossain, C. Gallippi
Low blood SNR makes detecting small vessels, measuring slow flow rates, and assessing blood perfusion without contrast administration challenging. A potential approach is to use Variance of Acceleration (VoA) imaging, which has been demonstrated previously in humans in vivo for monitoring subcutaneous bleeding and delineating intraplaque hemorrhage. We hypothesize that, without the addition of contrast agents, VoA can detect slow flow in small vessels for perfusion assessment. Experiments were performed on an ATS 700-D 527 calibrated flow phantom (vessel diameter of 1 mm, flow rates of 0-53 cm/s) and in the surgically exteriorized right kidneys of 3 pigs (2M/1F, mean body weight of 74.4 ± 9.3 kg) at baseline and after inducing ischemia. In the phantom, logVoA increased in the vessel with increasing flow rate, and it remained constant in the background. LogVoA values were higher in the background with versus without the ARF excitation. Similarly, logVoA values were higher in the vessel, particularly for flow rates < 12 cm/s, with versus without ARF excitation. Vessel CNR by logVoA was higher with versus without ARF excitation for flow rates < 12 cm/s, and CNR by logVoA was greater than CNR by power Doppler for all flow rates. Additionally, logVoA was statistically significantly greater at baseline than ischemia in all three in vivo pig kidneys. Finally, logVoA delineates a 1.25 mm-diameter vessel in a pig renal cortex in vivo, while power Doppler does not. These results suggest that logVoA could support contrast-free detection of slow blood flow in small vessels and in vivo perfusion assessment.
低血液信噪比使得检测小血管、测量慢流速和评估无对比剂的血液灌注具有挑战性。一种潜在的方法是使用加速度方差(VoA)成像,该成像先前已在人体体内被证明用于监测皮下出血和描绘斑块内出血。我们假设,在不添加造影剂的情况下,VoA可以检测小血管中的慢血流以进行灌注评估。实验在ATS 700-D 527校准的血流模型(血管直径为1 mm,流速为0-53 cm/s)上进行,并在3头猪(2M/1F,平均体重74.4±9.3 kg)的手术外置右肾(基线和诱导缺血后)上进行。在幻象中,随着流速的增加,血管中的logVoA增加,而在背景中保持不变。在有ARF激励的背景下,LogVoA值高于没有ARF激励的背景。同样,在有ARF激励的情况下,血管中的logVoA值更高,特别是在流速< 12 cm/s的情况下。当流速< 12 cm/s时,在ARF激励下,logVoA的血管CNR高于未加ARF激励的血管CNR,并且在所有流速下,logVoA的CNR都大于功率多普勒的CNR。此外,在所有三个活体猪肾脏中,logVoA在基线时显著高于缺血。最后,logVoA在活体猪肾皮质中描绘了直径1.25 mm的血管,而功率多普勒则没有。这些结果表明,logVoA可以支持无造影剂检测小血管慢血流和体内灌注评估。
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引用次数: 0
Non-Classical Second-Order Nonlinear Elastic Wave Interactions 非经典二阶非线性弹性波相互作用
Pub Date : 2019-10-01 DOI: 10.1109/ULTSYM.2019.8925682
A. Demčenko, M. Mazilu, R. Wilson, J. Reboud, J. Cooper
We report a novel ultrasonic measurement technique based on non-classical nonlinear evanescent field interactions. We demonstrate significant enhancement in sensitivity of contactless measurements at interfaces, with the potential to detect material degradation, such as fatigue and ageing, which is currently not possible using linear ultrasonics.
本文报道了一种基于非经典非线性倏逝场相互作用的新型超声测量技术。我们展示了界面处非接触式测量灵敏度的显著增强,具有检测材料退化的潜力,例如疲劳和老化,这是目前使用线性超声波无法实现的。
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引用次数: 1
Phase Aberration Correction in Transcranial Ultrasound Imaging using Averaged Sound Velocity Map in Delay-and-Sum Beamformer 利用延迟和波束形成器平均声速图校正经颅超声成像中的相位像差
Pub Date : 2019-10-01 DOI: 10.1109/ULTSYM.2019.8926091
Moein Mozaffarzadeh, Claudio Minonzio, M. Verweij, S. Hemm, V. Daeichin
Deep brain stimulation (DBS) is used to modify the brain function. Localization of the electrode(s) used in DBS is an important mater since the success of the treatment highly depends on it. Transcranial ultrasound imaging (TUI) can be a proper candidate to monitor the electrode(s), but it is affected by the phase aberration caused by the skull bone. To address this issue, in this paper, we propose a novel beamforming method based on the sound velocity map of the imaging medium. For each combination of the imaging grid and element of the array, an averaged sound speed (ASD) is calculated. Then, the ASD is used inside a delay-and-sum beamforming method. The numerical results show that the proposed method compensates the phase aberration caused by the skull having a thickness of 5 mm with a sound speed twice of the imaging medium (i.e., water). The proposed method can be implemented in a real-time manner, which makes it a great candidate to be used in operation rooms for surgeries.
脑深部电刺激(DBS)是用来改变大脑功能的。在DBS中使用的电极的定位是一个重要的问题,因为治疗的成功高度依赖于它。经颅超声成像(TUI)是监测电极的合适选择,但受颅骨引起的相位像差的影响。为了解决这一问题,本文提出了一种基于成像介质声速图的波束形成方法。对于成像网格和阵列单元的每个组合,计算平均声速(ASD)。然后,在延迟和波束形成方法中使用ASD。数值计算结果表明,所提出的方法以两倍于成像介质(即水)的声速补偿了厚度为5mm的颅骨所引起的相位像差。该方法可以实时实现,是手术室外科手术的理想选择。
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引用次数: 1
Detection and acoustical visualization of internal defects in shotcrete structures by spatial spectral entropy for noncontact acoustic inspection method 基于空间谱熵的喷射混凝土结构内部缺陷检测及声学可视化
Pub Date : 2019-10-01 DOI: 10.1109/ULTSYM.2019.8925999
K. Sugimoto, T. Sugimoto, H. Morioka, N. Utagawa, Chitose Kuroda, Takeyuki Ohdaira
Deterioration of concrete structures is a serious problem in social infrastructures such as tunnels and viaducts. In order to solve this problem, we have examined the method to inspect the internal defects of concrete structure in a noncontact and non-destructive manner. In our noncontact acoustic inspection method, the concrete surface is vibrated by strong airborne sound waves, 2-dimensional distribution of vibration velocity is measured by a scanning laser Doppler vibrometer (SLDV). And the internal defects (up to a depth of about 10 cm from the surface) is detected from a long distance (about 5-30m). It was made possible to detect internal defects of concrete with smooth surface in a released space such as a viaduct or a tunnel. However, in a closed space surrounded by concrete, such as an underground cavity, the S/N ratio was lowered due to reverberation from the surroundings. In shotcrete with uneven surface, the reflectance of laser light on the surface varies. And it is more difficult to detect internal defects. To detect internal defects of concrete, we have proposed the defect detection algorithm combining acoustic features (vibrational energy ratio and spectral entropy). At a measured point of internal defect, vibrational energy tends to be high and spectral entropy tends to be low. Since acoustic excitation is used, in a closed space, more intense resonance occurs in a head of SLDV due to reverberation from the surroundings. Since resonance frequency of a laser head and its frequency range can be detected by spatial spectral entropy (SSE) proposed previously, the resonance frequency peaks can be removed in data analysis. In addition, the influence of shotcrete surface was reduced by detecting resonance frequencies of internal defects on the measured surface by SSE, selecting frequency bands to analyze, and statistically evaluating healthy part by two acoustical features.
混凝土结构的劣化是隧道、高架桥等社会基础设施中的一个严重问题。为了解决这一问题,我们研究了一种非接触无损检测混凝土结构内部缺陷的方法。在非接触式声学检测方法中,混凝土表面受到强烈的空中声波的振动,用扫描激光多普勒振动计(SLDV)测量振动速度的二维分布。在较远的距离(约5-30m)内检测内部缺陷(深度可达距表面约10cm)。它可以在高架桥或隧道等释放空间中检测表面光滑的混凝土的内部缺陷。然而,在一个由混凝土包围的封闭空间中,如地下洞室,由于周围环境的混响,信噪比降低。在表面凹凸不平的喷射混凝土中,激光在表面的反射率会发生变化。而且内部缺陷的检测也比较困难。为了检测混凝土内部缺陷,我们提出了结合声学特征(振动能量比和谱熵)的缺陷检测算法。在内部缺陷测点处,振动能趋于高,谱熵趋于低。由于使用了声激励,在封闭空间中,由于周围环境的混响,SLDV的头部会发生更强烈的共振。由于空间谱熵可以检测激光头的共振频率及其频率范围,因此可以在数据分析中去除共振频率的峰值。此外,通过SSE检测被测表面内部缺陷的共振频率,选择频段进行分析,并通过两种声学特征对健康部分进行统计评价,降低了喷射混凝土表面的影响。
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引用次数: 1
Neural Network-Based Detection of Ultrasonic Targets with Respect to Noise and Number of Sampling Positions 基于噪声和采样位置数的超声目标神经网络检测
Pub Date : 2019-10-01 DOI: 10.1109/ULTSYM.2019.8926202
P. Kroh, Ralph Simon, S. Rupitsch
A neural network-based approach for detection of sonar targets in air is presented in this contribution. Our approach may facilitate autonomous mobile systems to reliably detect and classify objects in their surrounding by using sonar information. This task might be extremely important in changing as well as unorganized environments. We perform target iden-tification with long short-term memory networks as classifiers. Such are capable of dealing with variable numbers of echoes from multiple positions per input sequence, which facilitates more flexible operation. The impact of the number of recording positions per sequence and of noise is investigated. Furthermore, we demonstrate the improvement in classification performance in comparison to previously obtained results from multi-layer-perceptrons.
本文提出了一种基于神经网络的空中声纳目标探测方法。我们的方法可以促进自主移动系统通过使用声纳信息可靠地检测和分类周围的物体。这项任务在变化和无组织的环境中可能非常重要。我们使用长短期记忆网络作为分类器进行目标识别。这样可以处理每个输入序列中来自多个位置的可变数量的回波,从而便于更灵活的操作。研究了每个序列记录位置数和噪声的影响。此外,我们证明了与以前从多层感知器获得的结果相比,分类性能有所提高。
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引用次数: 1
FBAR Duplexers with Minimal Shunt Inductance for Better Isolation and Packing Density 具有最小分流电感的FBAR双工器,具有更好的隔离和包装密度
Pub Date : 2019-10-01 DOI: 10.1109/ULTSYM.2019.8926131
P. Bradley, S. Lee, M.S. Kang, J. Kim
Relentless pressure to reduce the size of filters, duplexers and multiplexers in mobile phone RF front end modules requires close packing of the filters and any associated PCB or SMT inductors. In these multiplexers, however, every Tx filter has to reject every Rx frequency and vice versa, while TDD bands/filters must be rejected by and reject nearly every other band -60 dB typical with -55 dB guaranteed. These seemingly contradictory requirements can both be satisfied if we reduce the magnitude of the grounding inductors of the filters to a point that their mutual inductance is not significantly degrading isolation. The Band 25 duplexer described is 1.5 mm x 1.1 mm x 0.6 mm.
在手机射频前端模块中,不断减小滤波器、双工器和多工器尺寸的压力要求滤波器和任何相关的PCB或SMT电感紧密封装。然而,在这些多路复用器中,每个Tx滤波器必须拒绝每个Rx频率,反之亦然,而TDD频带/滤波器必须拒绝并拒绝几乎所有其他频带-典型60 dB,保证-55 dB。如果我们减小滤波器接地电感的幅度,使它们的互感不会显著降低隔离,那么这些看似矛盾的要求都可以得到满足。Band 25双工器尺寸为1.5 mm x 1.1 mm x 0.6 mm。
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引用次数: 2
Vector Flow Velocity Estimation from Beamsummed Data Using Deep Neural Networks 基于深度神经网络的波束和数据矢量流速估计
Pub Date : 2019-10-01 DOI: 10.1109/ULTSYM.2019.8925825
Y. Li, D. Hyun, J. Dahl
Vector flow imaging (VFI) is a novel velocity measurement technique that provides flow velocity information in both azimuth and axial dimensions. Compared to conventional color Doppler imaging, VFI provides velocity estimation that is independent of flow directions. Previous VFI techniques utilize either multiple transmit or receive beams or angles, or speckle tracking. This creates a trade-off between computational intensity and estimate quality or equipment cost. In this work, we present a vector flow velocity estimation technique based on deep neural networks using only beamsummed radio-frequency (RF) data. The deep neural network extracts features from the RF data, and performs flow velocity estimation on the features, and maps the estimates back to the spatial domain. The structure and training of the neural network model is presented. The performance of the technique is demonstrated and evaluated using simulations and flow phantom experiments.
矢量流成像(VFI)是一种新型的速度测量技术,可以同时提供方位和轴向的流速信息。与传统的彩色多普勒成像相比,VFI提供了独立于流动方向的速度估计。以前的VFI技术利用多个发射或接收光束或角度,或斑点跟踪。这在计算强度和估计质量或设备成本之间产生了权衡。在这项工作中,我们提出了一种基于深度神经网络的矢量流速估计技术,该技术仅使用波束和射频(RF)数据。深度神经网络从射频数据中提取特征,对特征进行流速估计,并将估计映射回空间域。给出了神经网络模型的结构和训练方法。通过仿真和流动模拟实验对该技术的性能进行了验证和评价。
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引用次数: 3
Estimation of transducer translation using channel-domain correlation 利用信道域相关估计换能器平移
Pub Date : 2019-10-01 DOI: 10.1109/ULTSYM.2019.8925652
Nick Bottenus
Swept synthetic aperture imaging has been previously proposed as a method of extending the effective size of an ultrasound transducer to improve lateral resolution, especially at depth. This method requires precise knowledge of array position and orientation in space as it is moved across a field of view. Previous experimental realizations have used motorized translation stages or calibrated measurement arms to track the transducer. We demonstrate a 1 degree-of-freedom sweep device that constrains the transducer motion and enables a new channel-domain motion estimation method. This channel correlation method is compared against conventional speckle tracking motion estimation and the known applied motion from a motorized stage. Swept synthetic aperture was successfully performed in a phantom using both estimators without external position tracking to extend a 2 cm transducer over a 5 cm sweep and achieve a lateral resolution improvement of 70%.
扫描合成孔径成像先前已被提出作为一种扩大超声换能器有效尺寸的方法,以提高横向分辨率,特别是在深度。这种方法需要精确了解阵列在空间中的位置和方向,因为它在视野中移动。以前的实验实现使用机动平移台或校准测量臂来跟踪传感器。我们展示了一个1自由度的扫描装置,它限制了换能器的运动,并实现了一种新的信道域运动估计方法。将该通道相关方法与传统的散斑跟踪运动估计和已知的机动平台应用运动进行了比较。在无外部位置跟踪的情况下,利用两种估计器成功实现了扫描合成孔径,将2厘米的传感器扩展到5厘米的扫描范围,横向分辨率提高了70%。
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引用次数: 0
Strain sensitivity enhancement of ultrasonic waves in plates using phase filter 用相位滤波器增强超声波在平板中的应变灵敏度
Pub Date : 2019-10-01 DOI: 10.1109/ULTSYM.2019.8925997
Lucas M. Martinho, A. Kubrusly, N. Pérez, A. Braga, Jean Pierre von der Weid
Ultrasonic guided waves can be used to measure mechanical strain in plates due to the stress-induced velocity change. Strain monitoring is usually performed by measuring the time-of-flight shift. However, interpretation of results can be difficult due to wave mixing, mainly when several dispersive modes propagate, or in the presence of reflections. In these cases, the time-reversal focusing technique can be used to monitor the strain level, by observing the peak of the focused time-reversal signal, which changes proportionally to the strain level. However, not all components of the spectrum contribute with the same sensitivity to strain changes. In this paper, we developed a signal filtering procedure based on the phase of the Fourier spectrum that increases the time-reversal strain sensitivity. The time-reversal process is modified by using a new signal as reference which is synthesized relying on prior knowledge of the impulse response at some non-null strain level. The technique was evaluated with different pairs of transducers in an aluminium plate, effectively producing more strain-sensitive signals. However, high strain-sensitive signal presents poor energy concentration which, in turn, can be difficult to detect. The technique can be adapted to provide strain-robust signals.
超声导波可以用来测量由于应力引起的速度变化引起的板内机械应变。应变监测通常是通过测量飞行时间位移来进行的。然而,由于波的混合,主要是在几个色散模式传播或存在反射时,结果的解释可能很困难。在这种情况下,可以使用时间反转聚焦技术来监测应变水平,通过观察聚焦后的时间反转信号的峰值,该峰值与应变水平成比例变化。然而,并非所有谱的分量对应变变化的敏感性都相同。在本文中,我们开发了一种基于傅里叶谱相位的信号滤波方法,提高了时间反转应变灵敏度。利用非零应变水平下脉冲响应的先验知识合成的新信号作为参考,对时间反转过程进行了改进。在铝板上对不同的传感器进行了评估,有效地产生了更多的应变敏感信号。然而,高应变敏感信号表现出较差的能量集中,这反过来又难以检测。该技术可用于提供应变鲁棒信号。
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引用次数: 1
期刊
2019 IEEE International Ultrasonics Symposium (IUS)
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