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2019 IEEE International Ultrasonics Symposium (IUS)最新文献

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Wave Propagation in the Multilayered Low-pressure Near-space Atmosphere 多层低气压近空间大气中的波传播
Pub Date : 2019-10-01 DOI: 10.1109/ULTSYM.2019.8925658
Chao Li, Q. Guo, Hanyin Cui, Rushan Shen, Xiaodong Peng, Xuchen Shen, Yaqin Hou, Qinghua Gao, Jing Wang, Chongxing Liu
The variation of sound speeds of air and nitrogen gas at temperatures from 15 to −80 °C, and at gas pressures from 105 to 150 Pa have been measured in a KM2G space simulator. The objective is to provide the primary acoustic parameters to set up a proper multi-layered near-space atmosphere model, so that to simulate propagation paths of acoustic waves. From experimental data, sound speeds of both air and nitrogen gas decrease with the decreasing temperature from 15 to −80 °C and with the decreasing pressure from 105 to about 5000 Pa. However, sound speeds in the 15°C rare air and nitrogen gas slightly increase with the dropping pressure below 5000 Pa, and this trend becomes more obviously when the temperature is low. This dispersion characteristic of acoustic wave in the near-space atmosphere should be considered during simulation of wave propagation.
在KM2G空间模拟器上测量了温度在15 ~ - 80℃,气压在105 ~ 150pa时空气和氮气的声速变化。目的是为建立合适的多层近空间大气模型提供基本的声学参数,从而模拟声波的传播路径。从实验数据来看,空气和氮气的声速都随着温度从15℃降低到- 80℃,压力从105 Pa降低到5000 Pa左右而降低。而在15℃稀有空气和氮气中,声速在5000 Pa以下随压力下降而略有增加,且在温度较低时这种趋势更为明显。声波在近空间大气中的这种色散特性在模拟声波传播时应加以考虑。
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引用次数: 0
A General Framework for Channel Domain SVD Clutter Filtering 信道域SVD杂波滤波的通用框架
Pub Date : 2019-10-01 DOI: 10.1109/ULTSYM.2019.8925935
Kathryn A. Ozgun, B. Byram
Eigen-based clutter filtering of Doppler data has demonstrated greater clutter rejection performance than traditional filtering in a number of studies. However, practical translation of these eigen-based techniques to channel domain filtering applications is limited by their high computational burden. To enable efficient eigen-based filtering of channel data, we propose a domain-adaptive filtering framework. This technique involves using a basis set generated from RF data to filter delayed channel data. Preliminary findings suggest that this technique retains superior clutter rejection performance in comparison to conventional techniques.
许多研究表明,基于特征的多普勒杂波滤波比传统滤波具有更好的杂波抑制性能。然而,这些基于特征的技术在信道域滤波应用中的实际转化受到其高计算负担的限制。为了对信道数据进行有效的基于特征的滤波,我们提出了一种域自适应滤波框架。该技术涉及使用由射频数据生成的基集来滤波延迟信道数据。初步研究结果表明,与传统技术相比,该技术保留了优越的杂波抑制性能。
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引用次数: 1
CMUT with mechanically coupled plate actuators -Linearized electrostatic modeling 带有机械耦合板致动器的CMUT。线性化静电建模
Pub Date : 2019-10-01 DOI: 10.1109/ULTSYM.2019.8925938
Marcel Krenkel, S. Koch, M. Kupnik
This paper derives an analytical model of the electrostatic transduction of a capacitive micromachined ultrasonic transducer (CMUT) with mechanically coupled plate actuators. The mass of the coupling geometry significantly affects the dynamic deflection shape of the plate actuators. As the electrostatic transduction of a CMUT depends on the distance between both electrodes of these capacitive systems, the static and dynamic deflection shapes are taken into account for the small signal electrostatic behavior. The analysis of the electrostatic lumped elements, varying with the bias voltage, reveals a dependence on the deflection shape. A comparison with finite element simulations shows good agreement with the analytical model.
本文建立了带有机械耦合板作动器的电容式微机械超声换能器的静电转导解析模型。耦合几何结构的质量对板形作动器的动态挠度形状有显著影响。由于CMUT的静电转导取决于这些电容系统的两个电极之间的距离,因此考虑了静态和动态挠度形状的小信号静电行为。分析了静电集总元件随偏置电压的变化,揭示了偏转形状的依赖性。通过与有限元模拟的比较,证明了与解析模型的一致性。
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引用次数: 1
Acoustic Cluster Therapy displays theranostic capability in enhancing the effectiveness of liposomal doxorubicin treatment of human triple negative breast cancer in mice 声学簇疗法在增强阿霉素脂质体治疗小鼠人类三阴性乳腺癌的有效性方面显示出治疗能力
Pub Date : 2019-10-01 DOI: 10.1109/ULTSYM.2019.8925626
N. Bush, P. Sontum, J. Bamber, A. Healey, Anant Shah, G. Box, V. Kirkin, S. Kotopoulis, S. Kvåle, A. van Wamel, C. de Lange Davies
Acoustic Cluster Therapy (ACT) employs an intravenously-injected dispersion of clusters of microbubbles and oil microdroplets, in combination with ultrasound directed at the tumor, to enhance the delivery of a co-administered drug. Diagnostic ultrasound activates the clusters, causing the droplets to change phase and become large (> 20 m) bubbles which lodge in the tumor capillaries. Delivery-enhancement is then achieved using a low-frequency (e.g. 300 kHz) ultrasound field also directed at the tumor, which causes the stationary bubbles to pulsate whilst in direct contact with the vascular endothelium. ACT has been shown to significantly increase the efficacy of various chemotherapeutics in a variety of tumor models in mice. Here we demonstrate through preclinical in-vivo experiments that the efficacy of treating human triple negative breast cancer in mice with liposomal doxorubicin (Doxil®) is significantly enhanced by ACT; for example, 63 % of animals achieved complete, stable remission, in the group treated with the drug and ACT versus only 10 % for Doxil® alone (p < 0.02). We also show in the same experiments that the ACT contrast enhancement obtained under ultrasound activation of the ACT clusters, either before or during treatment, holds promise as an imaging biomarker for predicting response.
声学簇疗法(ACT)采用静脉注射分散的微泡簇和油微滴,结合针对肿瘤的超声,以增强联合给药的药物递送。诊断超声激活簇状液滴,使液滴改变相位,形成大气泡(> 20m),进入肿瘤毛细血管。然后,使用同样针对肿瘤的低频(例如300 kHz)超声场来实现输送增强,这使得静止的气泡在与血管内皮直接接触时产生脉动。ACT已被证明在多种肿瘤模型小鼠中显著提高各种化疗药物的疗效。本研究通过临床前体内实验证明,ACT可显著增强阿霉素脂质体(Doxil®)治疗小鼠人三阴性乳腺癌的疗效;例如,在药物和ACT治疗组中,63%的动物获得了完全、稳定的缓解,而单独使用Doxil®的动物只有10% (p < 0.02)。我们还在相同的实验中表明,在治疗前或治疗期间,超声激活ACT簇获得的ACT对比增强,有望作为预测反应的成像生物标志物。
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引用次数: 0
A Fully Convolutional Neural Network for Rapid Displacement Estimation in ARFI Imaging 基于全卷积神经网络的ARFI成像快速位移估计
Pub Date : 2019-10-01 DOI: 10.1109/ULTSYM.2019.8925911
Derek Y. Chan, D. Morris, M. Palmeri, K. Nightingale
Ultrasound elasticity imaging in soft tissue with acoustic radiation force requires extracting displacement information, typically on the order of several microns, from raw data. In this work, we implement a fully convolutional neural network for ultrasound displacement estimation. We present a novel method for generating ultrasound training data, in which virtual displacement volumes are created with a combination of randomly-seeded ellipsoids. Network performance was tested on the virtual displacement volumes as well as an experimental phantom dataset and human in vivo prostate data. In simulated and phantom data, the proposed neural network accurately reconstructed the ARFI displacements, performing similarly to a conventional phase-shift displacement estimation algorithm. Application of the trained network to in vivo prostate data enabled the visualization of the prostatic urethra and peripheral zone.
利用声辐射力对软组织进行超声弹性成像,需要从原始数据中提取位移信息,通常在几微米的量级上。在这项工作中,我们实现了一个用于超声波位移估计的全卷积神经网络。我们提出了一种生成超声训练数据的新方法,其中虚拟位移体积是由随机种子椭球的组合创建的。在虚拟位移体积、实验幻影数据集和人体内前列腺数据上测试了网络性能。在模拟和模拟数据中,所提出的神经网络精确地重建了ARFI位移,其性能与传统的相移位移估计算法相似。将训练好的网络应用于体内前列腺数据,实现了前列腺尿道和外周区的可视化。
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引用次数: 1
Polarization conversion of surface acoustic waves for enhanced microscale actuation applications 用于增强微尺度驱动应用的表面声波偏振转换
Pub Date : 2019-10-01 DOI: 10.1109/ULTSYM.2019.8926272
R. Weser, A. Darinskii, H. Schmidt
Surface acoustic wave (SAW) based actuators used for active microfluidic applications, most often utilize Rayleigh-type SAW with significant out-of-plane surface displacements. Besides the desired momentum transfer to the liquid in contact with the active surface, an additional, unwanted momentum transfer into the polymer wall of the microfluidic vessel also occurs. The energy dissipation inside the vessel wall decreases actuator efficiency and may result in leakage and degradation of the wall material. Our first investigations show that boundary polarized SAW modes with comparatively small out-of-plane displacement can also be used for microfluidic actuation purposes to overcome this drawback. The boundary polarized mode is capable to pass the vessel wall-substrate interface with minimum of acoustical loss, but needs to be converted finally inside the vessel into a vertical polarized mode in order to ensure the intended acoustofluidic interaction. Such a mode or polarization conversion can be realized by an appropriate scattering structure arranged inside the vessel area.
用于主动微流体应用的基于表面声波(SAW)的致动器,通常使用具有显着面外表面位移的瑞利型SAW。除了所需的动量转移到与活性表面接触的液体之外,还会发生额外的、不需要的动量转移到微流体容器的聚合物壁上。容器壁内的能量耗散降低了执行器的效率,并可能导致容器壁材料的泄漏和退化。我们的初步研究表明,具有相对较小的面外位移的边界极化SAW模式也可以用于微流体驱动目的,以克服这一缺点。边界极化模式能够以最小的声损失通过容器-基底界面,但最终需要在容器内部转换为垂直极化模式,以确保预期的声流相互作用。这种模式或偏振转换可以通过在容器区域内设置适当的散射结构来实现。
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引用次数: 0
Investigation of Optical Ultrasound Emission Mechanism Based on CNTs-PDMS Composite CNTs-PDMS复合材料光超声发射机理研究
Pub Date : 2019-10-01 DOI: 10.1109/ULTSYM.2019.8925668
Soo Won Kwon, Won Young Choi, K. Park
In this paper, we present an investigation into an optical ultrasound emission mechanism based on a composite of carbon nanotubes (CNTs) and polydimethylsiloxane (PDMS). The CNTs-PDMS composite was fabricated using a brush touch method with a multi-walled carbon nanotube (MWCNT) solution mixed with CNTs and isopropyl alcohol. To explore the optical ultrasound emission mechanism, three groups of specimens were fabricated. The first group was classified as having Nd:YAG laser spot sizes when using a convex lens. The second group was classified according to the coated thickness of the CNTs. Finally, the third group was classified according to the thickness of the PDMS. The CNTs-PDMS composite was placed in a water tank, and an Nd:YAG laser was irradiated onto the CNTs-PDMS composite to receive ultrasound waves generated using a hydrophone. A comparison of the results revealed that specimens with a small laser spot size, a thick coating of CNTs, and a thin PDMS layer achieved the highest frequency of ultrasound waves.
本文研究了基于碳纳米管(CNTs)和聚二甲基硅氧烷(PDMS)复合材料的光学超声发射机理。采用多壁碳纳米管(MWCNT)溶液与碳纳米管和异丙醇混合,采用刷触法制备了碳纳米管- pdms复合材料。为了探讨光学超声发射机理,制作了三组样品。当使用凸透镜时,第一组被归类为具有Nd:YAG激光光斑尺寸。第二组根据CNTs的包覆厚度进行分类。最后根据PDMS的厚度对第三组进行分类。将CNTs-PDMS复合材料置于水箱中,将Nd:YAG激光照射到CNTs-PDMS复合材料上,接收由水听器产生的超声波。结果表明,激光光斑尺寸较小、CNTs涂层较厚和PDMS层较薄的样品获得的超声波频率最高。
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引用次数: 0
Characterization of High Intensity Ultrasound Exposures by Quantitative Ultrasound 高强度超声暴露的定量超声表征
Pub Date : 2019-10-01 DOI: 10.1109/ULTSYM.2019.8925754
V. Barrère, E. Franceschini, D. Melodelima
High Intensity Ultrasound (HIU) is of proven value in the treatment of many medical disorders by using US energy without incisions or radiation. The development of an effective method for guiding HIU therapies remains necessary. Changes in spectral-based Quantitative UltraSound (QUS) parameters have been correlated with the temperature changes during HIU exposure (Ghoshal et al. IEEE UFFC 2016). The aim of this study is to quantify the changes in QUS parameters due to temperature elevation after HIU exposure of ex vivo bovine livers. The QUS experiments are conducted in high frequencies (12-38 MHz) to provide insight into the specific changes in liver tissues that cause the changes of backscatter properties for fixed temperature ranging from 37°C up to 80°C after HIU exposure.Samples of porcine livers are exposed to HIU using a plane 3 MHz transducer with aperture diameter of 4 cm. Samples were heated up to 37, 50, 60, 65, 70, 75, 80°C. After reaching the desired temperature, the sample is cut in half at the center of the lesion. US backscatter signals were recorded from the cut samples by using the Visualsonics Vevo 770 imaging system with the RMV710 probe of center frequency 25 MHz. The backscatter coefficients (BSCs) were estimated using the reference phantom technique and the attenuation coefficients were determined using a standard substitution method.Structural scatterer properties were estimated by fitting the measured BSCs with the spherical Gaussian model (SGM) or with the Structure Factor Model (SFM) to estimate the effective scatterer diameter (ESD) and acoustic concentration (EAC). The QUS parameters estimated by the sparse SGM and the concentrated SFM differ strongly from each other for HIU treated samples and suggests that the treated livers can be considered as concentrated media. Results showed that both integrated BSC and ESD estimated by the SFM increased as a function of temperature.
高强度超声(HIU)在许多医学疾病的治疗中被证明是有价值的,因为它使用美国能量而没有切口或辐射。开发一种有效的方法来指导HIU治疗仍然是必要的。基于光谱的定量超声(QUS)参数的变化与HIU暴露期间的温度变化相关(Ghoshal等)。Ieee uffc 2016)。本研究的目的是量化暴露在离体牛肝脏后,由于温度升高而引起的QUS参数的变化。QUS实验在高频率(12-38 MHz)下进行,以深入了解HIU暴露后肝组织在37°C至80°C的固定温度下引起背散射特性变化的具体变化。使用孔径直径为4厘米的平面3mhz换能器将猪肝样品暴露于HIU中。将样品加热至37、50、60、65、70、75、80℃。在达到所需温度后,将样品在病变中心切成两半。使用中心频率为25 MHz的RMV710探头的Visualsonics Vevo 770成像系统记录切割样品的美国反向散射信号。采用参考模体技术估算后向散射系数,采用标准代入法确定衰减系数。利用球形高斯模型(SGM)或结构因子模型(SFM)拟合测量的BSCs,估计有效散射体直径(ESD)和声浓度(EAC),从而估计结构散射体特性。在HIU处理的样品中,稀疏SGM和浓缩SFM估计的QUS参数差异很大,这表明处理过的肝脏可以被认为是浓缩培养基。结果表明,SFM估算的综合BSC和ESD均随温度的升高而升高。
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引用次数: 0
A High Power Circuit Model of an FBAR Resonator for Use in Filter Design 用于滤波器设计的FBAR谐振器大功率电路模型
Pub Date : 2019-10-01 DOI: 10.1109/ULTSYM.2019.8925762
S. Setoodeh, U. Kemiktarak, F. Bayatpur, S. Fouladi, D. Feld
FBAR resonators comprise a thin film metal-piezoelectric-metal membrane with an air cavity on either side. Under high power operation an FBAR resonator exhibits a radial temperature distribution. A high power electro-thermal model must incorporate this radial temperature distribution so that it can adequately capture a resonator’s electrical behavior including hysteresis. Prior electro-thermal models, which have been used to model the high-power performance of solidly mounted BAW resonators, assume a uniform temperature distribution in the radial direction, and are thus incompatible for use in modeling FBAR resonators.
FBAR谐振器包括薄膜金属-压电-金属膜,其两侧各有一个空腔。在高功率工作下,FBAR谐振腔呈现径向温度分布。高功率电热模型必须包含这种径向温度分布,以便能够充分捕捉谐振器的电行为,包括磁滞。先前的电热模型用于模拟固体安装的BAW谐振器的高功率性能,假设径向温度分布均匀,因此不适合用于模拟FBAR谐振器。
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引用次数: 2
Tiled Large Element 1.75D Aperture with Dual Array Modules by Adjacent Integration of PIN-PMN-PT Transducers and Custom High Voltage Switching ASICs 通过相邻集成PIN-PMN-PT换能器和定制高压开关asic,平铺大元件1.75D孔径双阵列模块
Pub Date : 2019-10-01 DOI: 10.1109/ULTSYM.2019.8925552
R. Wodnicki, Yu Liu, Victoria Chiu, D. Stephens, Qifa Zhou, K. Ferrara, Haochen Kang, Di Li, Yizhe Sun, Laiming Jiang, Ruimin Chen, Zeyu Chen, Hayong Jong, J. Foiret
Tiled large aperture 1.75D/2D transducer arrays with closely integrated ASIC electronics have the potential for implementing high channel count ultrasound probes for novel applications, however they must have high yield for a large number of elements to maintain good image quality. This constraint can be addressed by tiling together a number of smaller array modules to build up the larger aperture. In this work we present recent imaging results for large apertures with multiple tiled array modules integrating 2D arrays of wide bandwidth PIN-PMN-PT 1-3 composite piezo elements with custom-designed ASICs for buffering and multiplexing functions. The ASICs are optimized to obtain increased sensitivity of the high impedance 2D elements using buffering. We have also been developing novel second-generation ASICs to mitigate the effects of switching transients observed while imaging with the first-generation devices.
具有紧密集成ASIC电子器件的平铺大孔径1.75D/2D传感器阵列具有实现高通道计数超声探头的新应用的潜力,但是它们必须具有大量元件的高良率以保持良好的图像质量。这种限制可以通过将一些较小的阵列模块平铺在一起来建立更大的孔径来解决。在这项工作中,我们展示了大孔径的多个平铺阵列模块的最新成像结果,该模块集成了宽带PIN-PMN-PT 1-3复合压电元件的二维阵列和定制设计的用于缓冲和多路复用功能的asic。asic经过优化,可以使用缓冲提高高阻抗2D元件的灵敏度。我们也一直在开发新的第二代asic,以减轻在使用第一代设备成像时观察到的开关瞬态的影响。
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引用次数: 8
期刊
2019 IEEE International Ultrasonics Symposium (IUS)
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