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Numerical simulation-based performance improvement of the separation of circulating tumor cells from bloodstream in a microfluidic platform by dielectrophoresis 基于数值模拟的微流控平台介质电泳分离循环肿瘤细胞的性能改进
IF 1.3 4区 工程技术 Q2 MECHANICS Pub Date : 2022-08-12 DOI: 10.1007/s13367-022-00039-6
Ngoc-Viet Nguyen, Hoang Van Manh, Nguyen Van Hieu

Circulating tumor cells (CTCs) detection has become one of the promising solutions for the early diagnosis of cancers. Thus, the separation of CTCs is of great importance in biomedical applications. In addition, microfluidic technology has been an attractive approach to the manipulation of biological cells. This study presents the parametric investigations relevant to the volumetric throughput of a microfluidic platform with the dielectrophoresis (DEP)-based cell manipulation technique for the continuous CTCs separation. A low potential voltage at an appropriate frequency was applied to slanted planar electrodes to separate CTCs from normal cells in blood samples due to mainly the cell size difference. The performance of the separation process was analyzed by evaluating the cell trajectories, purity, and recovery rates. Several inlet flow rates of buffer and cell sample fluid streams were examined. Various channel configurations with different outlet and height dimensions were also investigated to enhance the isolation of CTCs. During the simulation, the size and shape of cells were assumed as fixed-sized, solid spheres. The results showed that CTCs could be separated from blood cells, including white blood cells (WBCs), red blood cells (RBCs), and platelets (PLTs) with recovery and purity factors up to 100% at the cell sample throughput of 10 µL/min by utilizing a suitable microchannel design. The current study significantly contributes valuable insights into the design of the microchip devices to effectively and selectively isolate different cancerous cells in biofluids.

Graphical abstract

循环肿瘤细胞(CTCs)检测已成为癌症早期诊断的重要手段之一。因此,ctc的分离在生物医学应用中具有重要意义。此外,微流体技术已经成为操纵生物细胞的一种有吸引力的方法。本研究采用基于介质电泳(DEP)的细胞操作技术,对微流控平台连续分离ctc的体积通量进行了参数化研究。在倾斜平面电极上施加适当频率的低电位电压,将血液样品中的ctc与正常细胞分离,主要是由于细胞大小的差异。通过评估细胞轨迹、纯度和回收率来分析分离过程的性能。研究了缓冲液和细胞样品流的几种进口流速。还研究了不同出口和高度尺寸的通道配置,以提高ctc的隔离。在模拟过程中,假设细胞的大小和形状为固定大小的固体球体。结果表明,采用合适的微通道设计,在10 μ L/min的细胞样品通量下,ctc可从白细胞(wbc)、红细胞(rbc)和血小板(PLTs)等血细胞中分离,回收率和纯度可达100%。目前的研究为微芯片设备的设计提供了有价值的见解,以有效和选择性地分离生物体液中的不同癌细胞。图形抽象
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引用次数: 3
Dissipative particle dynamics modeling of MR fluid flow in a novel magnetically optimized mini-MR damper 磁流变流体在新型磁优化微磁流变阻尼器中的耗散粒子动力学建模
IF 1.3 4区 工程技术 Q2 MECHANICS Pub Date : 2022-08-08 DOI: 10.1007/s13367-022-00037-8
Mohsen Ghafarian Eidgahi Moghadam, Mohammad Mohsen Shahmardan, Mahmood Norouzi

Magnetically optimization of mini-MR damper with focused on MR fluid properties and damper construction is investigated using dissipative particle dynamics method as a molecular scale modeling technique. To select a suitable MR fluid, the effect of diameter and weight of magnetic particles on damping force of 10 N as set point is studied. The results show damping force increases by increasing diameter of magnetic particles and finally trends to a constant value while changes nonparabolic by enhancement of their weight. The results of studies on structural parameters of damper show that by increasing gap size of flow passage, damping force increases while enhancement in inner diameter of cylinder and piston length has reverse effect. Optimum design of MR damper completed by investigation on electrical coils in terms of their arrangement and step wise distribution of magnetic field strength as our major innovation. To optimum operating conditions of MR damper at minimum electrical energy consumption and hysteresis level, the scenario of three segment coils in length of 3, 5, and 7 mm at base relative magnetic strength of 40% with 15% difference in steps by utilizing 140CG MR fluid as agent fluid are selected.

采用耗散粒子动力学方法作为分子尺度建模技术,研究了基于磁流变流体特性和阻尼器结构的微型磁流变阻尼器的磁优化问题。为了选择合适的磁流变液,研究了磁颗粒直径和磁颗粒质量对10 N阻尼力的影响。结果表明:阻尼力随磁性颗粒直径的增大而增大,最终趋于恒定,随磁性颗粒重量的增大而呈非抛物线型变化。对阻尼器结构参数的研究结果表明,随着流道间隙尺寸的增大,阻尼力增大,而增大气缸内径和活塞长度则会产生相反的效果。磁流变阻尼器的优化设计主要是通过对线圈的布置和磁场强度的阶跃分布进行研究来完成的。为了优化磁流变阻尼器在最小电能消耗和磁滞水平下的运行工况,选择了以140CG磁流变液为剂液,在相对磁强为40%、步长差为15%的情况下,长度为3、5、7mm的3段线圈。
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引用次数: 1
How to resolve the trade-off between performance and long-term stability of magnetorheological fluids 如何解决磁流变液的性能和长期稳定性之间的权衡
IF 1.3 4区 工程技术 Q2 MECHANICS Pub Date : 2022-08-04 DOI: 10.1007/s13367-022-00036-9
Junsok Choi, Junyoung Lim, Sangsok Han, Hoyeon Kim, Hyoung Jin Choi, Yongsok Seo

A suspension of micro- or nano-magnetic particles dispersed in a nonmagnetic carrier medium is called a magnetorheological (MR) fluid. MR fluids are smart materials that undergo rapid and reversible changes in rheological properties under an external magnetic field. The rheological properties of MR fluids can be easily controlled through manipulation of the magnetic field strength. Because of their unique and fast reversible changes in rheological properties, MR fluids are widely used in various devices and structures. However, they suffer long-term stability (particle sedimentation) problems because of the density mismatch between the suspended magnetic particle and the liquid medium. In previous studies, researchers have expended great efforts to simultaneously improve the stability and performance of MR fluids. Nevertheless, a trade-off relationship exists between the stability and the performance of MR fluids, that is, as MR performance increases, stability decreases, and vice versa. In this review, we recapitulate the findings of our group's recent achievements and address the conflicting issues. Reviewing the various routes will provide clues to solving the trade-off problem and suggest a guideline for developing high-performance and highly stable MR fluids.

分散在非磁性载体介质中的微磁性或纳米磁性颗粒的悬浮液称为磁流变(MR)流体。磁流变流体是一种智能材料,在外部磁场作用下,流变特性会发生快速可逆的变化。磁流变液的流变特性可以很容易地通过操纵磁场强度来控制。由于其独特且快速可逆的流变特性变化,磁流变液被广泛应用于各种器件和结构中。然而,由于悬浮的磁性颗粒与液体介质之间的密度不匹配,它们存在长期稳定性(颗粒沉降)问题。在以往的研究中,研究人员花费了大量的精力来同时提高磁流变液的稳定性和性能。然而,稳定性与MR流体性能之间存在一种权衡关系,即MR性能增加,稳定性降低,反之亦然。在这篇综述中,我们总结了我们小组最近取得的成就,并解决了相互矛盾的问题。回顾各种途径将为解决权衡问题提供线索,并为开发高性能和高稳定的MR流体提供指导。
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引用次数: 4
Experimental measurements of non-Newtonian fluid flow through a stenotic tube 非牛顿流体通过狭窄管的实验测量
IF 1.3 4区 工程技术 Q2 MECHANICS Pub Date : 2022-08-03 DOI: 10.1007/s13367-022-00038-7
Imane Trea, Mohamed Mahfoud, Fadila Haddad

This paper presents an experimental study of the laminar flow of a non-Newtonian fluid through 75% (by area reduction) stenotic tubes. The fluid behaviour was described by the Herschel Bulkey non-Newtonian model. The non-Newtonian fluids were aqueous solutions of 0.1% Carbopol 940. Upstream flow conditions were steady and spanned a range of generalized Reynolds numbers Reg from 0.20 to 13.66. The velocity profiles were measured with a Laser Doppler Anemometry (LDA). This study allows us to see locally the influence of the geometry and the non-Newtonian character of the fluid on the velocity profiles, the pressure drops and flow resistance. From the experimental data, the frictional resistance decreases with increasing generalized Reynolds number Reg and resistance gave a weak value in a stenotic tube as compared to the flow in a simple tube. At the level of stenosis, a correlation relating of the Euler number to the generalized Reynolds number is developed. To compare the upstream and downstream parts of the stenosis, it is preferable to represent the pressure drops by the friction factor f. This factor f in upstream and downstream decreases linearly with the generalized Reynolds number Reg.

本文对非牛顿流体通过75%(面积缩小)狭窄管的层流进行了实验研究。流体行为由Herschel Bulkey非牛顿模型描述。非牛顿流体为0.1%卡波波尔940的水溶液。上游流动条件稳定,广义雷诺数Reg范围为0.20 ~ 13.66。用激光多普勒测速仪(LDA)测量了风速分布。这项研究使我们能够在局部看到流体的几何形状和非牛顿特性对速度分布、压降和流动阻力的影响。从实验数据来看,摩擦阻力随广义雷诺数Reg的增加而减小,与简单管中的流动相比,狭窄管中的阻力值较小。在狭窄水平上,建立了欧拉数与广义雷诺数的相关关系。为了比较狭窄的上下游部分,最好用摩擦系数f来表示压降。该系数f在上下游随广义雷诺数Reg线性减小。
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引用次数: 0
Squeeze flow and rheological characterization of pure bitumen and bitumen mixed with kaolin 纯沥青和掺高岭土沥青的挤压流动和流变特性
IF 1.3 4区 工程技术 Q2 MECHANICS Pub Date : 2022-06-29 DOI: 10.1007/s13367-022-00035-w
Amal Kraiem, Abdelhak Ayadi, Nadia Elkissi

This study dealt with an experimental squeeze-flow test between two parallel disks and rheological measurements using a rotational rheometer of pure bitumen and bitumen mixed with 10 and 20 wt.% kaolin without slip condition. The experimental procedure of the homogeneous samples’ preparation was described. A steady-state and dynamic rheological analysis for pure bitumen and bitumen mixed with kaolin was detailed. Results show that pure bitumen and bitumen mixed with 10 wt.% kaolin at 26 °C correspond to a shear-thinning behavior. The effect of the kaolin particles becomes more critical at low shear rates than at high shear rates, where the matrix effect was dominant. The influence of temperature on bitumen mixed with 20 wt.% kaolin was investigated, and the obtained results show that the samples behave like a power-law model at 50 °C. Besides, the squeeze-flow test impact at an ambient temperature of 26 °C for pure bitumen and bitumen mixed with kaolin was also studied. Adding kaolin leads to a significant increase in viscosity and confirms the studied cases in the rheometry test at 26 °C. It was proven that pure bitumen and bitumen mixed with kaolin follow a power-law model at a specific range of shear rate. In particular, the decrease of the shear rate in bitumen mixed with 20 wt.% kaolin triggers the detection of the yield stress, which did not appear in the rheological measurements due to the applied deformation either in the shear and/or the elongational flow.

本研究处理了两个平行圆盘之间的实验挤压流动测试,并使用旋转流变仪对纯沥青和混合了10%和20%高岭土的沥青进行了流变学测量,无滑移条件。介绍了制备均相样品的实验过程。对纯沥青和掺高岭土沥青进行了稳态和动态流变学分析。结果表明,纯沥青和掺10 wt.%高岭土的沥青在26℃时均发生剪切减薄;高岭土颗粒的影响在低剪切速率下比在高剪切速率下更为关键,在高剪切速率下,基质效应占主导地位。研究了温度对掺加20 wt.%高岭土的沥青的影响,结果表明,样品在50℃时表现为幂律模型。此外,还研究了纯沥青和掺高岭土沥青在26℃环境温度下的挤压流冲击试验。添加高岭土导致粘度显著增加,并证实了26°C流变试验中的研究情况。证明了纯沥青和掺高岭土沥青在特定剪切速率范围内服从幂律模型。特别是,在掺有20%高岭土的沥青中,剪切速率的降低触发了屈服应力的检测,这在流变学测量中没有出现,因为在剪切和/或拉伸流动中施加了变形。
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引用次数: 0
Practical operations for intermittent dual-layer slot coating processes 间歇式双层槽涂覆工艺的实际操作
IF 1.3 4区 工程技术 Q2 MECHANICS Pub Date : 2022-06-14 DOI: 10.1007/s13367-022-00033-y
Jin Seok Park, Sanghun Jee, Byoungjin Chun, Hyun Wook Jung

Transient behaviors of dual-layered patches for Newtonian liquids were numerically investigated in dual-layer slot coating processes for the first time using step-changed inlet flows. To further tune the leading and trailing edges in a patch cycle, startup and end lag times between the top and bottom layers were proposed, considering the flow state of a bottom-layer liquid in a coating bead region. Carefully chosen lag times significantly reduced the defects in the leading and trailing edges of a dual-layered patch. It was also found that a greater coating layer viscosity results in a greater amount of residue left on the die lips, which affects the next patch cycle.

本文首次采用步进变化的进口流,对牛顿液体双层补片在双层槽涂覆过程中的瞬态行为进行了数值研究。为了进一步调整贴片周期的前后边缘,考虑涂层珠区底层液体的流动状态,提出了顶层和底层之间的启动和结束滞后时间。精心选择的滞后时间显著减少了双层贴片前后边缘的缺陷。还发现,较大的涂层粘度导致在模唇上留下更多的残留物,从而影响下一个贴片周期。
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引用次数: 1
Correction to: Simulated orientational morphology from the measured transient rheology of polycarbonate–carbon fiber composites 修正:从测量的聚碳酸酯-碳纤维复合材料的瞬态流变模拟取向形态
IF 1.3 4区 工程技术 Q2 MECHANICS Pub Date : 2022-06-08 DOI: 10.1007/s13367-022-00034-x
Javad Rahmannezhad, Hyeon Dam Jeong, Seung Chan Ryu, Heon Sang Lee
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引用次数: 1
Application of numerical differentiation to conversion of linear viscoelastic functions 数值微分在线性粘弹性函数转换中的应用
IF 1.3 4区 工程技术 Q2 MECHANICS Pub Date : 2022-05-31 DOI: 10.1007/s13367-022-00030-1
Junghaeng Lee, Kwang Soo Cho

We propose a new method to calculate relaxation time spectrum (RTS) and enable conversions between viscoelastic functions. The exact relations between the viscoelastic functions are simply derived using complex analysis of the higher-order derivative of those functions. Hence, a stable numerical differential method is demanded to obtain genuine solutions without the interference of errors due to numerical analysis. In this study, we adopted the double-logarithmic B-spline and its recursive relation to obtain higher-order derivative. The proposed algorithm is tested and compared with previous methods, using simulated and experimental data. When creep data obtained through experiments are converted to dynamic moduli, significant improvement in the terminal behavior is observed compared to the previous method because the Runge phenomenon is significantly reduced using a low-order polynomial. Moreover, the spectra obtained for experimental data are almost identical to those obtained through a previously verified algorithm. Thus, our results agree well with both simulated data and experimental data.

我们提出了一种计算松弛时间谱(RTS)并实现粘弹性函数之间转换的新方法。通过对粘弹性函数的高阶导数的复变分析,简单地推导出粘弹性函数之间的精确关系。因此,需要一种稳定的数值微分方法来获得不受数值分析误差干扰的真解。在本研究中,我们采用双对数b样条及其递推关系来获得高阶导数。利用仿真数据和实验数据对该算法进行了测试和比较。当将实验得到的蠕变数据转换为动态模量时,由于使用低阶多项式显著降低了龙格现象,因此与之前的方法相比,终端行为有了显著改善。此外,实验数据得到的光谱与通过先前验证的算法得到的光谱几乎相同。因此,我们的结果与模拟数据和实验数据都吻合得很好。
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引用次数: 0
Correction to: State-of-the-art recent developments of large magnetorheological (MR) dampers: a review 修正:大型磁流变(MR)阻尼器的最新发展:综述
IF 1.3 4区 工程技术 Q2 MECHANICS Pub Date : 2022-05-17 DOI: 10.1007/s13367-022-00032-z
Mohammad Abdul Aziz, Sakib Muhammad Mohtasim, Rubel Ahammed
{"title":"Correction to: State-of-the-art recent developments of large magnetorheological (MR) dampers: a review","authors":"Mohammad Abdul Aziz,&nbsp;Sakib Muhammad Mohtasim,&nbsp;Rubel Ahammed","doi":"10.1007/s13367-022-00032-z","DOIUrl":"10.1007/s13367-022-00032-z","url":null,"abstract":"","PeriodicalId":683,"journal":{"name":"Korea-Australia Rheology Journal","volume":"34 3","pages":"241 - 241"},"PeriodicalIF":1.3,"publicationDate":"2022-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s13367-022-00032-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4698589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of increased particle concentration on magnetorheological fluid properties and their damping performance 颗粒浓度增加对磁流变液性能及其阻尼性能的影响
IF 1.3 4区 工程技术 Q2 MECHANICS Pub Date : 2022-05-11 DOI: 10.1007/s13367-022-00029-8
Ashok Kumar Kariganaur, Hemantha Kumar, M. Arun

Magnetorheological (MR) fluid properties are essential in analyzing the performance of any MR fluid system. The fluid properties are dependent on shape, size, and magnetic saturation of the magnetic particles. Preliminary characteristics with SEM, particle size analysis (PSA), and vibration sample magnetometer (VSM) on carbonyl iron particles were performed to verify the particle’s feasibility to synthesize the MR fluid in a laboratory. Synthesis and characterization of MR fluids with particle concentrations (PC) of 10% (PC10), 15% (PC15), 20% (PC20), 30% (PC30), and 35% (PC35) by volume are carried out. To show the inherent nonlinearity of the MR fluid, Herschel–Bulkley model is used. The relationship between sedimentation velocity, yield stress, and thermal conductivity is established as a function of particle concentration with experimental uncertainty of 6.15, 5, and 8.96%, respectively. Functional testing of PC15 and PC30 was carried out on an MR damper fabricated on dimensions obtained from the literature for the required size. The results indicate that damping force is 42% more in PC30 than PC15 at higher loading parameters. Finally, the saturation magnetization of the MR fluid depends not only on applied current but also on loading parameters when operating in the system.

磁流变(MR)流体特性是分析任何磁流变流体系统性能的基础。流体性质取决于磁性颗粒的形状、大小和磁饱和度。通过扫描电镜(SEM)、粒度分析(PSA)和振动样品磁强计(VSM)对羰基铁颗粒进行初步表征,验证了羰基铁颗粒在实验室中合成磁流变液的可行性。对颗粒浓度(PC)分别为体积分数10% (PC10)、15% (PC15)、20% (PC20)、30% (PC30)和35% (PC35)的MR流体进行了合成和表征。为了显示磁流变液固有的非线性,采用了Herschel-Bulkley模型。建立了沉降速度、屈服应力和导热系数与颗粒浓度的关系,实验不确定度分别为6.15%、5%和8.96%。在一个MR阻尼器上进行了PC15和PC30的功能测试,该阻尼器的尺寸从文献中获得所需尺寸。结果表明,在较高的加载参数下,PC30的阻尼力比PC15大42%。最后,磁流变液的饱和磁化强度不仅与外加电流有关,还与系统运行时的负载参数有关。
{"title":"Impact of increased particle concentration on magnetorheological fluid properties and their damping performance","authors":"Ashok Kumar Kariganaur,&nbsp;Hemantha Kumar,&nbsp;M. Arun","doi":"10.1007/s13367-022-00029-8","DOIUrl":"10.1007/s13367-022-00029-8","url":null,"abstract":"<div><p>Magnetorheological (MR) fluid properties are essential in analyzing the performance of any MR fluid system. The fluid properties are dependent on shape, size, and magnetic saturation of the magnetic particles. Preliminary characteristics with SEM, particle size analysis (PSA), and vibration sample magnetometer (VSM) on carbonyl iron particles were performed to verify the particle’s feasibility to synthesize the MR fluid in a laboratory. Synthesis and characterization of MR fluids with particle concentrations (PC) of 10% (PC<sub>10</sub>), 15% (PC<sub>15</sub>), 20% (PC<sub>20</sub>), 30% (PC<sub>30</sub>), and 35% (PC<sub>35</sub>) by volume are carried out. To show the inherent nonlinearity of the MR fluid, Herschel–Bulkley model is used. The relationship between sedimentation velocity, yield stress, and thermal conductivity is established as a function of particle concentration with experimental uncertainty of 6.15, 5, and 8.96%, respectively. Functional testing of PC<sub>15</sub> and PC<sub>30</sub> was carried out on an MR damper fabricated on dimensions obtained from the literature for the required size. The results indicate that damping force is 42% more in PC<sub>30</sub> than PC<sub>15</sub> at higher loading parameters. Finally, the saturation magnetization of the MR fluid depends not only on applied current but also on loading parameters when operating in the system.</p></div>","PeriodicalId":683,"journal":{"name":"Korea-Australia Rheology Journal","volume":"34 3","pages":"223 - 238"},"PeriodicalIF":1.3,"publicationDate":"2022-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4469600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
期刊
Korea-Australia Rheology Journal
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