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Remarks on GRN-type systems 关于grn型系统的备注
Pub Date : 2020-01-01 DOI: 10.1051/fopen/2020009
Eduard Brokan, F. Sadyrbaev
Systems of ordinary differential equations that appear in gene regulatory networks theory are considered. We are focused on asymptotical behavior of solutions. There are stable critical points as well as attractive periodic solutions in two-dimensional and three-dimensional systems. Instead of considering multiple parameters (10 in a two-dimensional system) we focus on typical behaviors of nullclines. Conclusions about possible attractors are made.
考虑了基因调控网络理论中出现的常微分方程组。我们关注解的渐近行为。在二维和三维系统中,既有稳定的临界点,也有吸引人的周期解。我们没有考虑多个参数(二维系统中有10个参数),而是关注空线的典型行为。对可能的吸引子进行了总结。
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引用次数: 5
COVID-19: Paradox of increasing capacities versus focus on Hippocratic ethics? COVID-19:提高能力与关注希波克拉底伦理的悖论?
Pub Date : 2020-01-01 DOI: 10.1051/fopen/2020003
G. Anogeianakis
A simple statistical review of the results of the increased availability of ICU beds in the EU shows that irrespective of whether a country has a lot of ICU beds or just a few, the death rates due to COVID-19 is still the same (P = 0 34, Fig 1 and Tab 1) An answer to the paradox comes from a group of intensive care physicians from long-suffering Italy [2], who claim that, at present, attention is focused mainly on increasing capacities (e g , the number of ICU beds, respirators and intensive care units, etc ) Conflict of interest The author, George Anogeianakis, certifies that he has no financial conflict of interest (e g , consultancies, stock ownership, equity interest, patent/licensing arrangements, etc ) in connection with this article 1
一个简单的统计评估的结果增加了可用性重症护理病床欧盟表明,无论一个国家是否有很多ICU床或几,死亡率由于COVID-19还是一样的(P = 0 34,图1和选项卡1)悖论的答案来自一群重症监护医生从坚忍的意大利[2],他们声称,目前,注意力主要集中在增加能力(e g,加护病房床位的数量,利益冲突作者George Anogeianakis证明,他没有与本条有关的经济利益冲突(例如,咨询、股票所有权、股权、专利/许可安排等)
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引用次数: 0
COVID-19: Pandemic surgery guidance COVID-19:大流行手术指导
Pub Date : 2020-01-01 DOI: 10.1051/fopen/2020002
B. Brücher, G. Nigri, A. Tinelli, J. F. Lapeña, E. Espín-Basany, P. Macrì, E. Matevossian, Sergio Ralon, R. Perkins, R. Lück, R. Kube, J. Costa, Y. Mintz, M. Tez, S. Allert, S. Sökmen, A. Spychała, B. Zilberstein, F. Marusch, M. Kermansaravi, W. Kycler, D. Vicente, M. Scherer, A. Rivkind, N. Elias, G. Wallner, F. Roviello, L. Santos, Raimund JC Araujo, A. Szold, Raúl Oleas, M. Rupnik, J. Salber, I. Jamall, A. Engel
Based on high quality surgery and scientific data, scientists and surgeons are committed to protecting patients as well as healthcare staff and hereby provide this Guidance to address the special issues circumstances related to the exponential spread of the Coronavirus disease 2019 (COVID-19) during this pandemic. As a basis, the authors used the British Intercollegiate General Surgery Guidance as well as recommendations from the USA, Asia, and Italy. The aim is to take responsibility and to provide guidance for surgery during the COVID-19 crisis in a simplified way addressing the practice of surgery, healthcare staff and patient safety and care. It is the responsibility of scientists and the surgical team to specify what is needed for the protection of patients and the affiliated healthcare team. During crises, such as the COVID-19 pandemic, the responsibility and duty to provide the necessary resources such as filters, Personal Protective Equipment (PPE) consisting of gloves, fluid resistant (Type IIR) surgical face masks (FRSM), filtering face pieces, class 3 (FFP3 masks), face shields and gowns (plastic ponchos), is typically left up to the hospital administration and government. Various scientists and clinicians from disparate specialties provided a Pandemic Surgery Guidance for surgical procedures by distinct surgical disciplines such as numerous cancer surgery disciplines, cardiothoracic surgery, ENT, eye, dermatology, emergency, endocrine surgery, general surgery, gynecology, neurosurgery, orthopedics, pediatric surgery, reconstructive and plastic surgery, surgical critical care, transplantation surgery, trauma surgery and urology, performing different surgeries, as well as laparoscopy, thoracoscopy and endoscopy. Any suggestions and corrections from colleagues will be very welcome as we are all involved and locked in a rapidly evolving process on increasing COVID-19 knowledge.
基于高质量的外科手术和科学数据,科学家和外科医生致力于保护患者和医护人员,并在此提供本指南,以解决与本次大流行期间2019冠状病毒病(COVID-19)指数传播相关的特殊问题。作为基础,作者使用了英国校际普通外科指南以及来自美国、亚洲和意大利的建议。其目的是在COVID-19危机期间以简化的方式承担责任并为手术提供指导,解决手术实践、医护人员和患者安全与护理问题。科学家和手术团队有责任明确保护患者和附属医疗团队所需的措施。在2019冠状病毒病大流行等危机期间,提供必要资源(如过滤器、个人防护装备(PPE),包括手套、抗液体(IIR型)外科口罩(FRSM)、过滤面罩、3级(FFP3口罩)、面罩和长袍(塑料雨披))的责任和义务通常由医院管理部门和政府承担。来自不同专业的科学家和临床医生为不同外科学科的外科手术提供了流行外科指南,如众多癌症外科学科、心胸外科、耳鼻喉科、眼科、皮肤科、急诊、内分泌外科、普通外科、妇科、神经外科、骨科、儿科外科、重建和整形外科、外科重症监护、移植外科、创伤外科和泌尿外科,进行不同的手术。还有腹腔镜,胸腔镜和内窥镜。我们非常欢迎来自同事的任何建议和更正,因为我们都参与并锁定在一个快速发展的过程中,以增加COVID-19知识。
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引用次数: 56
Multi-messengers at ultra-high energies with the Pierre Auger Observatory 皮埃尔·奥格天文台的超高能量多信使
Pub Date : 2020-01-01 DOI: 10.1051/fopen/2020004
J. Souchard
The Pierre Auger Observatory is an Ultra-High Energy Cosmic Ray (UHECR) detector which has studied cosmic particles with energies above and around 1018 eV for more than 15 years. It has proved to be the most competitive instrument at these energies and has produced a wealth of valuable results, improving our understanding of UHECRs. A complete understanding of these highest energy particles is crucial to understand the extreme astrophysical events in which they are produced and accelerated, as well as their propagation to Earth. In the same range of energies, UHE photons and neutrinos are of paramount importance as, being electrically neutral, they point back to their origin while charged particles are deflected in the galactic and extragalactic magnetic fields. The flux of extragalactic photons, neutrinos, and cosmic rays are believed to be highly linked, by their origin and their interactions. Each messenger provides different information about the potential sources, and having detection means for all four messengers, including gravitational waves, allows us to shed light on energetic sources of astroparticles. The Pierre Auger Observatory benefits from a large exposure and a good angular resolution, and is efficient in detecting UHE photons and neutrinos. These performances make possible follow-up searches for events detected by gravitational waves, such as the binary mergers observed by the LIGO/Virgo detectors, or any other energetic sources of particles.
皮埃尔·奥格天文台是一个超高能量宇宙射线(UHECR)探测器,它研究能量在1018 eV以上和左右的宇宙粒子已经超过15年了。它已被证明是在这些能量下最具竞争力的仪器,并产生了大量有价值的结果,提高了我们对uhecr的理解。全面了解这些最高能量粒子对于理解它们产生和加速的极端天体物理事件以及它们向地球的传播至关重要。在相同的能量范围内,超高能光子和中微子是至关重要的,因为它们是电中性的,当带电粒子在银河系和星系外磁场中偏转时,它们指向它们的起源。星系外光子、中微子和宇宙射线的通量被认为是高度相关的,因为它们的起源和相互作用。每个信使都提供了关于潜在来源的不同信息,对所有四种信使都有探测手段,包括引力波,使我们能够阐明天体粒子的高能来源。皮埃尔·奥格天文台得益于大曝光和良好的角度分辨率,在探测超高能光子和中微子方面效率很高。这些性能使得后续搜索引力波探测到的事件成为可能,比如LIGO/Virgo探测器观测到的双星合并,或者任何其他高能粒子源。
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引用次数: 0
A copula based representation for tailings dam failures 尾矿坝溃坝的一种基于联结关系的表示
Pub Date : 2020-01-01 DOI: 10.1051/fopen/2020011
Laura Maria Canno Ferreira Fais, V. González-López, D. S. Rodrigues, Rafael Rodrigues de Moraes
In this article, we model the dependence between dam factor and D max, where dam factor is an indicator of risk of a tailings dam failure, which involves the height H of the tailings dam, the volume of material housed by the tailings dam VT and the volume dispensed by the tailings dam, VF, when the dam breaks. And, Dmax is the maximum distance traveled by the material released by the tailings dam, after the collapse. With the dependence found via copula models and Bayesian estimation, given a range of dam factor, we estimate the probability of the released material to exceed a certain threshold. Since the dam factor involves the released volume VF (unknown before the dam break), we present a naive way to estimate it using VT and H. In this way, it is possible to estimate the dam factor of a tailings dam and with such a value to identify the probability of the tailings dam to show a Dmax that exceeds a certain threshold.
在本文中,我们建立了坝系数与Dmax之间的关系模型,其中坝系数是衡量尾矿库溃坝风险的一个指标,它涉及尾矿库高度H、尾矿库所容纳的物料体积VT和溃坝时尾矿库所分配的体积VF。其中,Dmax为尾矿坝崩塌后释放的物料所移动的最大距离。根据copula模型和贝叶斯估计的相关性,给定一定范围的大坝因子,我们估计了释放物质超过某一阈值的概率。由于坝因子涉及到溃坝前未知的释放体积VF,我们提出了一种利用VT和h来估计坝因子的朴素方法,这样就可以估计出尾矿坝的坝因子,并利用这个值来识别尾矿坝出现Dmax超过某一阈值的概率。
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引用次数: 0
More on algebraic properties of the discrete Fourier transform raising and lowering operators 更多关于离散傅里叶变换升降算子的代数性质
Pub Date : 2019-07-24 DOI: 10.1063/1.5114023
M. Atakishiyeva, N. Atakishiyev, J. Loreto-Hernández
In the present work, we discuss some additional findings concerning algebraic properties of the N-dimensional discrete Fourier transform (DFT) raising and lowering difference operators, recently introduced in [Atakishiyeva MK, Atakishiyev NM (2015), J Phys: Conf Ser 597, 012012; Atakishiyeva MK, Atakishiyev NM (2016), Adv Dyn Syst Appl 11, 81–92]. In particular, we argue that the most authentic symmetrical form of discretization of the integral Fourier transform may be constructed as the discrete Fourier transforms based on the odd points N only, while in the discrete Fourier transforms on the even points N this symmetry is spontaneously broken. This heretofore undetected distinction between odd and even dimensions is shown to be intimately related with the newly revealed algebraic properties of the above-mentioned DFT raising and lowering difference operators and, of course, is very consistent with the well-known formula for the multiplicities of the eigenvalues, associated with the N-dimensional DFT. In addition, we propose a general approach to deriving the eigenvectors of the discrete number operators N(N), that avoids the above-mentioned pitfalls in the structure of each even-dimensional case N = 2L.
在本工作中,我们讨论了最近在[Atakishiyeva MK, Atakishiyev NM(2015)]中引入的关于n维离散傅立叶变换(DFT)升差算子和降差算子的代数性质的一些额外发现[J] .物理学报:科学版,597,012012;刘建军,刘建军,刘建军,等。[j].计算机工程,2016,(1):1 - 2。特别地,我们认为积分傅里叶变换离散化的最真实的对称形式可以构造为仅基于奇数点N的离散傅里叶变换,而在偶数点N上的离散傅里叶变换中,这种对称性会自发地被打破。这种迄今为止未被发现的奇维和偶维之间的区别被证明与上述DFT上升和降低差分算子的新发现的代数性质密切相关,当然,这与众所周知的与n维DFT相关的特征值的多重性公式非常一致。此外,我们提出了一种推导离散数算子N(N)的特征向量的一般方法,避免了在每个偶数维情况N = 2L的结构中存在的上述缺陷。
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引用次数: 4
Eigenvalues of matrices related to the octonions 与八元数相关的矩阵的特征值
Pub Date : 2019-01-01 DOI: 10.1051/FOPEN/2019014
R. Serôdio, P. Beites, J. Vitória
A pseudo real matrix representation of an octonion, which is based on two real matrix representations of a quaternion, is considered. We study how some operations defined on the octonions change the set of eigenvalues of the matrix obtained if these operations are performed after or before the matrix representation. The established results could be of particular interest to researchers working on estimation algorithms involving such operations.
在四元数的两个实数矩阵表示的基础上,考虑了一个八元数的伪实数矩阵表示。我们研究了定义在八元数上的一些操作,如果在矩阵表示之后或之前执行这些操作,如何改变矩阵的特征值集。对于研究涉及此类操作的估计算法的研究人员来说,已确定的结果可能会特别感兴趣。
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引用次数: 1
Stochastic profile of Epstein-Barr virus in nasopharyngeal carcinoma settings 爱泼斯坦-巴尔病毒在鼻咽癌环境中的随机分布
Pub Date : 2019-01-01 DOI: 10.1051/FOPEN/2019020
M. Cordeiro, J. E. García, V. González-López, Sergio L. M. londono
We build a profile of the Epstein-Barr virus (EBV) by means of genomic sequences obtained from patients with nasopharyngeal carcinoma (NPC). We consider a set of sequences coming from the NCBI free source and we assume that this set is a collection of independent samples of stochastic processes related by an equivalence relation. Given a collection {(Xjt)t∈ℤ}pj=1 of p independent discrete time Markov processes with finite alphabet A and state space S, we state that the elements (i, s) and (j, r) in {1, 2,…, p} × S are equivalent if and only if they share the same transition probability for all the elements in the alphabet. The equivalence allows to reduce the number of parameters to be estimated in the model avoiding to delete states of S to achieve that reduction. Through the equivalence relationship, we build the global profile for all the EBV in NPC sequences, this model allows us to represent the underlying and common stochastic law of the set of sequences. The equivalence classes define an optimal partition of {1, 2,…, p} × S, and it is in relation to this partition that we define the profile of the set of genomic sequences.
本文利用从鼻咽癌(NPC)患者中获得的基因组序列建立了eb病毒(EBV)的基因图谱。我们考虑一组来自NCBI自由源的序列,并假设这组序列是由等价关系相关的随机过程的独立样本的集合。给定具有有限字母a和状态空间S的p个独立离散时间马尔可夫过程的集合{(Xjt)t∈0}pj=1,我们声明{1,2,…,p} × S中的元素(i, S)和(j, r)当且仅当它们在字母中所有元素具有相同的转移概率时是等价的。等效性允许减少模型中需要估计的参数数量,避免为了减少而删除S的状态。通过等价关系,我们建立了NPC序列中所有EBV的全局轮廓,该模型使我们能够表示序列集合的基本和共同的随机规律。等价类定义了{1,2,…,p} × S的最优划分,并根据该划分定义了基因组序列集的剖面。
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引用次数: 3
A copula-based consistency analysis of education indicators 基于copula的教育指标一致性分析
Pub Date : 2019-01-01 DOI: 10.1051/FOPEN/2019013
C. Cunha, Mariela Fernández, J. E. García, V. González-López, N. Romano
In this paper we investigate the consistency of quality indicators of the Brazilian public educational system. According to the newspaper Estado de São Paulo – Brazil, of January 18, 2017, only 7.3% of students in the third year of high school have an adequate level of mathematics, this shows the relevance of the evaluation and assessment of the Brazilian educational system. In this paper we explore the dependence between two indicators: (i) mean value between the proportions (in two subjects: Portuguese and Mathematics) of students under the basic level (SARESP classification) and (ii) rate of fails, during the years 2013, 2014 and 2015. (i) and (ii) are bases to define the educational quality of public schools for the population of young people, between 14 and 17 years old. This inspection is carried out through the Bayesian estimation of the parameters of the Asymmetric Cubic Sections (ACS) copula. We show that the dependence profile, year after year, behaves in a very unstable way, although during those years there were no substantial changes which justify such instability. Through the copula we compute conditional probabilities of tail events. We verify that an inversion occurred in the concordance/discordance between (i) and (ii). We compute the probability of (i) assuming high values, conditioned to a threshold in (ii). In 2013, as the threshold in (ii) increases the probability increases (concordance), in 2014 the threshold in (ii) is almost irrelevant to the probability and in 2015, as the threshold in (ii) increases the probability decreases (discordance). The inspection of the tail dependence allows to expose some kind of manipulation, in view of for instance, the maintenance of a global index índice de desenvolvimento da educação de São Paulo (IDESP) used to classify the educational institutions.
本文研究了巴西公共教育系统质量指标的一致性。据巴西《圣保罗州报》2017年1月18日报道,在高中三年级,只有7.3%的学生具有足够的数学水平,这显示了巴西教育体系评估和评估的相关性。在本文中,我们探讨了两个指标之间的依赖关系:(i)在2013年,2014年和2015年期间,基础水平(SARESP分类)学生的比例(在两个科目中:葡萄牙语和数学)与(ii)不合格率之间的平均值。(一)和(二)是界定公立学校对14至17岁青年人口的教育质量的基础。这种检验是通过对非对称立方截面(ACS)联结的参数进行贝叶斯估计来实现的。我们表明,年复一年,依赖概况的表现非常不稳定,尽管在那些年里没有实质性的变化证明这种不稳定是合理的。通过联结公式计算尾事件的条件概率。我们验证了(i)和(ii)之间的一致性/不一致性发生了反转。我们计算了(i)假设高值的概率,条件为(ii)中的阈值。2013年,随着(ii)中的阈值增加,概率增加(一致性),2014年(ii)中的阈值几乎与概率无关,2015年,随着(ii)中的阈值增加,概率减少(不一致性)。对尾部依赖关系的检查允许暴露某种操纵,例如,维护用于对教育机构进行分类的全球指数índice de desenvolvimento da educa o de s o Paulo (IDESP)。
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引用次数: 0
German nursing shortage in hospitals – Homemade by Profititis? 德国医院护士短缺——利润造成的?
Pub Date : 2019-01-01 DOI: 10.1051/FOPEN/2019007
B. Brücher, D. Deufert
The shortage of nursing staff in Germany compromises public healthcare in deference to profits explaining why this is on the daily political and media agenda. In Germany, over a 22 year period, significant savings were achieved by decreases in: (1) hospital beds by −29.3% saving 119 000 beds, (2) patient care and treatment days by −23% saving 43.1 million patient days, and (3) length of hospital stay in days by −39% saving 4.7 days. This occurred together with the parallel increase of treated patient cases by +26.5% with an additional burden of 4.1 million patients. Since 2010, as birth rates increase again treatment cases will also increase. In parallel, the percentage of total nurses has decreased (−2.1%) as well as that of registered nurses in hospitals between 1999 (325 539) and 2009 (324 337) have decreased (−0.4%), in conjunction with nurses employed in preventive and rehabilitation facilities (+15.1%) and/or in outpatient care facilities (+41.1%) and/or nursing homes (+24.8%) and/or nurses working in retirement homes (+77.9%). This “profititis” endangers both patient care and detracts from people joining the nursing profession. It might even be a short-sighted tightrope act which, in the end, might counteract the marketing strategy of “patient safety” by risking quality of patient care. Maybe healthcare politics would be well-advised to re-think the fact that as the population gets older and as birth rates and immigration increases, these factors could result in increased patient caseloads in hospitals which need to be addressed now so as to avert a future crisis.
在德国,护理人员的短缺损害了公共医疗保健,这就解释了为什么这是日常政治和媒体议程上的问题。在德国,在22年期间,通过以下方式实现了显著节约:(1)医院病床减少了29.3%,节省了119 000张病床;(2)病人护理和治疗日减少了23%,节省了4310万病人日;(3)住院天数减少了39%,节省了4.7天。与此同时,接受治疗的患者病例平行增加了26.5%,增加了410万患者的负担。自2010年以来,随着出生率再次上升,治疗病例也将增加。与此同时,在1999年(325 539人)至2009年(324 337人)期间,护士总数的百分比下降(- 2.1%),医院注册护士的百分比下降(- 0.4%),预防和康复设施(+15.1%)和/或门诊护理设施(+41.1%)和/或养老院(+24.8%)雇用的护士和/或养老院工作的护士(+77.9%)也下降了。这种“利润”既危及病人的护理,也减损了人们加入护理职业的兴趣。这甚至可能是一种目光短浅的走钢丝行为,最终可能会危及患者护理质量,从而抵消“患者安全”的营销策略。也许医疗政治应该重新考虑这样一个事实,即随着人口老龄化、出生率和移民的增加,这些因素可能导致医院的病人数量增加,现在需要解决这些问题,以避免未来的危机。
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引用次数: 9
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