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Surgical reconstruction of the columella after necrosis caused by an infantile hemangioma. 婴儿血管瘤坏死后小柱的外科重建。
IF 0.8 4区 医学 Q4 SURGERY Pub Date : 2025-10-01 Epub Date: 2025-06-17 DOI: 10.1080/00015458.2025.2520785
Rocío Terrados, María San Basilio, Manuel de la Torre, Concepción Lorca-García, Beatriz Berenguer

Background: Infantile hemangiomas are common vascular tumors in childhood that usually undergo spontaneous involution. However, complications may arise, particularly in visible areas such as the centrofacial region, leading to significant aesthetic and functional sequelae. Columellar necrosis is a rare but challenging complication requiring specialized reconstruction techniques.

Methods: This report presents two cases of columellar necrosis caused by infantile hemangiomas. Reconstruction was achieved using a 3-component technique: cartilage grafts for tip support, oral vestibule mucosal flaps for lateral lining, and cutaneous turn out flaps from the columellar stumps for anterior skin coverage.

Results: Both patients achieved excellent functional and aesthetic outcomes. The described technique allowed for reliable reconstruction of the columella, addressing both structural integrity and cosmetic appearance.

Conclusion: Reconstruction of columellar defects, particularly in pediatric cases, is challenging due to the columella's small size and challenging anatomy. The described 3-component technique offers a reproducible and effective approach for isolated columellar defects, ensuring satisfactory functional and aesthetic results.

背景:婴儿血管瘤是儿童时期常见的血管肿瘤,通常自发复发。然而,并发症可能会出现,特别是在可见区域,如面部中心区域,导致显著的美学和功能后遗症。小柱坏死是一种罕见但具有挑战性的并发症,需要专门的重建技术。方法:报告2例婴幼儿血管瘤所致小柱坏死。重建采用三组份技术:软骨移植用于鼻尖支持,口腔前庭粘膜皮瓣用于侧衬,小柱残端皮肤转出皮瓣用于前部皮肤覆盖。结果:两例患者均获得了良好的功能和美观效果。所描述的技术允许可靠的重建小柱,解决结构完整性和美容外观。结论:小柱缺损的重建,特别是在儿童病例中,由于小柱的小尺寸和具有挑战性的解剖结构,是具有挑战性的。所描述的三组分技术为分离的小柱状缺陷提供了一种可重复和有效的方法,确保了令人满意的功能和美学结果。
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引用次数: 0
An early report of using protecting gloves by Ḥakim Mohammad, a Persian surgeon (16th century CE). 波斯外科医生Ḥakim Mohammad(公元16世纪)关于使用防护手套的早期报告。
IF 0.8 4区 医学 Q4 SURGERY Pub Date : 2025-08-01 Epub Date: 2025-04-08 DOI: 10.1080/00015458.2025.2489802
Narges Tajik, Zahra Ghahremani, Sobhan Ghezloo, Shahrzad Irannejad, Arman Zargaran

Background: Although using gloves in surgery dates back to the nineteenth century in modern medicine, it seems that the earliest evidence can be found in the Middle Ages.

Methods: It is a library research-based study on the book of Ḏaḫīre-ye Kāmele, written by Ḥakim Mohammad (Ḥakīm Muhammad), a Persian surgeon in the sixteenth century.

Results: Ḥakim Mohammad advises the surgeons to use a sheath made of sheep testicle skin for their fingers when examining a wound and putting ointment and bandage on it to protect oneself from diseases that are transmitted through the skin and blood, such as people with wounds whose wounds are caused by smallpox, anthrax, leprosy and infectious wounds.

Conclusion: The words of Ḥakim Mohammad suggest a preliminary concept of using surgical gloves to prevent transmitted diseases, dating back to sixteenth century, 3 centuries before its use in modern era.

背景:虽然在手术中使用手套可以追溯到19世纪的现代医学,但似乎最早的证据可以在中世纪找到。方法:以16世纪波斯外科医生Ḥakim Mohammad (Ḥakīm Muhāmmad)的著作Ḏaḫīre-ye Kāmele为基础进行的图书馆研究。结果:Ḥakim穆罕默德建议外科医生在检查伤口时使用羊睾丸皮肤制成的护套,并在伤口上涂上药膏和绷带,以保护自己免受通过皮肤和血液传播的疾病的侵害,例如伤口由天花,炭疽,麻风病和感染性伤口引起的伤口。结论:Ḥakim Mohammad的话暗示了使用手术手套来预防传播疾病的初步概念,可追溯到16世纪,比现代使用早了3个世纪。
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引用次数: 0
Cervico-thoracic paraganglioma associated with Horner's syndrome: a case report. 颈胸副神经节瘤合并霍纳综合征1例。
IF 0.8 4区 医学 Q4 SURGERY Pub Date : 2025-08-01 Epub Date: 2025-06-09 DOI: 10.1080/00015458.2025.2512488
Naïla El Nakadi, Jâd Abi-Khalil, Sarah Landenne, Isabelle De Quin, Jean Lemaitre

Background: Cervico-thoracic paragangliomas are rare hypervascular neuroendocrine tumors, with high morbidity and mortality due to locally invasive growth. They are often misdiagnosed in patients with cervical masses. Horner's syndrome, in this case, results from a lesion of the stellate ganglion. Only a few cases in the literature describe paragangliomas affecting the stellate ganglion.

Case report: We report the case of a 61-year-old female with a cervico-thoracic paraganglioma associated with Horner's syndrome. She had no significant medical history. Cervical computed tomography (CT) and magnetic resonance imaging (MRI) revealed a large, highly vascularized antero-superior mediastinal mass measuring 6.8 cm x 5 cm x 9 cm, surrounding the left subclavian and carotid arteries, and slightly compressing the trachea, esophagus, and innominate vein. Surgery provided the definitive diagnosis through histopathological analysis. We highlight the different types of paragangliomas and the challenges in diagnosis. A 2-year follow-up with CT and PET-CT scans confirmed no recurrence of the lesion.

Conclusions: Paragangliomas are rare, slow-growing neuroendocrine tumors that may appear wherever autonomic ganglia are present. Clinical presentations vary, including lesions of the stellate ganglion causing ipsilateral Horner's syndrome. Paragangliomas should be considered in the differential diagnosis of cervico-thoracic masses. Treatment involves complete surgical resection while preserving neurovascular structures.

背景:颈胸副神经节瘤是一种罕见的高血管神经内分泌肿瘤,因其局部侵袭性生长而具有很高的发病率和死亡率。宫颈肿块患者常被误诊。霍纳综合症,在这个病例中,是由星状神经节损伤引起的。文献中仅有少数病例描述副神经节瘤累及星状神经节[1,2]。«病例报告»:我们报告一例61岁女性颈-胸副神经节瘤合并霍纳综合征。她没有明显的病史。颈椎计算机断层扫描(CT)和磁共振成像(MRI)显示一个大的、血管密集的前-上纵隔肿块,尺寸为6.8 cm x 5 cm x 9 cm,环绕左侧锁骨下动脉和颈动脉,并轻微压迫气管、食道和无名氏静脉。手术通过组织病理学分析提供了明确的诊断。我们强调不同类型的副神经节瘤和诊断的挑战。2年随访CT和PET-CT扫描证实病变未复发。结论:副神经节瘤是一种罕见的生长缓慢的神经内分泌肿瘤,可能出现在任何有自主神经节的地方。临床表现各不相同,包括星状神经节病变引起同侧霍纳综合征。副神经节瘤在颈胸肿块的鉴别诊断中应予以考虑。治疗包括完全手术切除,同时保留神经血管结构[3]。
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引用次数: 0
A prospective diagnostic accuracy study of the Alvarado score in a Croatian hospital - is it time for a final conclusion? 克罗地亚一家医院对阿尔瓦拉多评分的前瞻性诊断准确性研究——是得出最终结论的时候了吗?
IF 0.8 4区 医学 Q4 SURGERY Pub Date : 2025-08-01 Epub Date: 2025-06-03 DOI: 10.1080/00015458.2025.2512279
Branko Bakula, Ante Bogut, Andrija Karačić, Maja Bakula, Antonio Marić, Vanja Radišić Biljak

Background: The diagnosis of acute appendicitis (AA) still represents a considerable problem for surgeons, with a relatively high rate of false positive findings still present. Thus, the aim of our study was to evaluate the diagnostic accuracy of the Alvarado scoring system based on the prospectively included subjects who presented to the emergency department with suspected AA.

Methods: From June 2018 to May 2020, 176 adult patients examined in the Emergency surgical department of University Hospital Sveti Duh with suspicion of AA were prospectively included in the study. The decision on the need for surgery in all patients was made by the same surgeon based only on clinical judgment and remained independent of any diagnostic scoring system.

Results: Fifty-eight (33.0%) of them were operated with negative appendectomy rate of 17.2%. Results showed that the surgeon's decision-making process is superior to the Alvarado scoring system (sensitivity and specificity were 96 and 92.06% vs. 84 and 87.30%, respectively).

Conclusion: The Alvarado scoring system proved to be a worse predictor of the diagnosis of AA compared to the assessment of an experienced surgeon and is not an adequate diagnostic tool for confirming the diagnosis. Only in a narrow group of patients in whom, based on the clinical examination, an indication for surgery has already been established, the Alvarado scoring system can potentially be useful in excluding the diagnosis with considerable caution in terms of close follow-up of the patient.Abbreviations: MSCT: multislice computed tomography; AA: acute appendicitis.

背景:急性阑尾炎的诊断对外科医生来说仍然是一个相当大的问题,仍然存在相对较高的假阳性率。因此,我们研究的目的是评估Alvarado评分系统的诊断准确性,该评分系统基于前瞻性纳入到急诊室就诊的疑似急性阑尾炎患者。方法:前瞻性纳入2018年6月至2020年5月在Sveti Duh大学医院急诊外科检查的176例疑似急性阑尾炎的成年患者。所有患者是否需要手术的决定均由同一位外科医生根据临床判断作出,独立于任何诊断评分系统。结果:58例(33.0%)行阑尾切除术,阴性率为17.2%。结果显示,外科医生的决策过程优于Alvarado评分系统(敏感性和特异性分别为96和92.06%,比84和87.30%)。结论:与经验丰富的外科医生的评估相比,Alvarado评分系统被证明是急性阑尾炎诊断的一个较差的预测指标,并且不是一个足够的诊断工具来确认诊断。只有在基于临床检查,已经确定手术指征的少数患者中,Alvarado评分系统才能在排除诊断时发挥潜在的作用,并且在密切随访患者方面相当谨慎。
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引用次数: 0
Surgical training; destination unknown? A survey on surgical employment in Flanders. 外科培训;去向不明?
IF 0.8 4区 医学 Q4 SURGERY Pub Date : 2025-08-01 Epub Date: 2025-04-29 DOI: 10.1080/00015458.2024.2391176
Niels Komen, Marian Vanhoeij, Paul De Leyn, Frederik Berrevoet, Piet Pattyn, Guy Hubens

Background: A surgical fellowship allows both additional training as well as maintenance of surgical skills while searching for a steady job. As the presence of fellows usually does not result in a measurably higher productivity, fellowships may be considered a form of disguised unemployment. The aim of this study is to evaluate the career flow of a surgical trainee to a staff position and to determine the number of surgeons working on temporary basis within the general surgery workforce in Flanders.

Methods: All surgeons graduated in Flanders between 2000 and 2022 were invited to fill out a web-based survey concerning their current and past employment. Reminders were sent out after 2 and 4 weeks. Statistical analysis was performed with SPSS version 27.0 (IBM Inc., Chicago, IL).

Results: Response rate was 64% (292/457) with 76% of respondents currently working as surgeons, 14% (38) as fellows and 10% working outside the surgical domain. Eighty-two percent of current fellows graduated in 2019 or later. Thirty-one percent of surgeons graduated in 2019 are still working as fellows. For surgeons graduated in 2020, 2021 and 2022, this is 45%, 80% and 90%, respectively. Compared to staff surgeons, the number of additional training years (2.8 ± 1.0 vs. 2.2 ± 1.3; p = .009) and the number of applications (6.6 ± 5 vs. 3.3 ± 3; p < .001) are significantly higher for current fellows.

Conclusion: This study shows that disguised unemployment is present in the general surgical community in Flanders. The status of 'fellow' should be incorporated in calculations concerning future needs of the surgical workforce in order to prevent open unemployment.

背景 外科研究员可以在寻找稳定工作的同时接受额外的培训并保持外科技能。由于研究员的存在通常不会显著提高工作效率,因此研究员可能被认为是一种变相的失业。本研究的目的是评估从外科实习生到职员的职业流向,并确定佛兰德普外科队伍中从事临时工作的外科医生人数。2 周和 4 周后分别发出提醒函。结果 答复率为 64%(292/457),其中 76% 的受访者目前担任外科医生,14%(38 人)担任研究员,10% 在外科领域以外工作。82%的研究员毕业于 2019 年或之后。在 2019 年毕业的外科医生中,有 31% 仍在担任研究员。2020、2021 和 2022 年毕业的外科医生中,这一比例分别为 45%、80% 和 90%。与外科医生相比,在职研究员的额外培训年数(2,8 ± 1,0 vs 2,2 ± 1,3;p = 0,009)和申请数量(6,6 ± 5 vs 3,3 ± 3;p < 0,001)明显高于外科医生。在计算未来外科劳动力需求时,应将 "研究员 "身份纳入其中,以防止公开失业。
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引用次数: 0
Surgical management of pseudomyxoma peritonei: low-volume center experience. 腹膜假性黏液瘤的外科治疗:小容积中心经验。
IF 0.8 4区 医学 Q4 SURGERY Pub Date : 2025-08-01 Epub Date: 2025-05-26 DOI: 10.1080/00015458.2025.2510121
Charif Khaled, Lina Safar, Alain Hendlisz, Maria Gomez Galdon, Paulus Kristanto, Michel Moreau, Ana Veron Sanchez, Gabriel Liberale

Introduction: Pseudomyxoma peritonei (PMP) is a rare disease characterized by diffuse peritoneal invasion of multifocal mucinous deposits. Gold standard treatment involves cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC). We aimed to compare the outcomes of operated PMP patients in a low-volume center, with those of high-volume centers and using other regimens.

Materials and methods: Retrospective analysis was conducted for PMP patients treated by CRS + HIPEC (using the Elias high-dose Oxaliplatin HIPEC regimen) over a 15-year period (January 2007 - December 2021) at the Jules Bordet Institute - H.U.B.

Results: 32 patients were included. Pathology results were: 21.9% acellular mucin, 34.4% low-grade, and 43.7% high-grade. The median peritoneal cancer index was 24 (range 3-36). The median follow-up was 58 months. The rate of major complications (Clavien-Dindo III/IV) was 41% and postoperative mortality was 3%. Mean disease-free survival (DFS) was estimated at 40 +/- 4 months (standard deviation (SD)) while overall survival (OS) was 122 +/- 9 months (SD). DFS reached a plateau of 44.5% at 5 and 10 years and OS was 92.3% and 76.2% respectively. Statistical analysis showed low-grade PMP to be predictive of better DFS and OS (p = 0.0111 and p = 0.0293 respectively). We also found that female gender was predictive of better DFS (p = 0.0262).

Conclusion: Our postoperative morbidity and mortality rates, DFS, and OS were similar to those reported in the literature for high-volume PMP centers. Our theory is that surgical proficiency can be more attributed to the surgeon's CRS experience, regardless of the nature of the disease.

腹膜假性黏液瘤(PMP)是一种罕见的疾病,其特征是腹膜弥漫性浸润多灶性黏液沉积。金标准治疗包括细胞减少手术(CRS)和腹腔内高温化疗(HIPEC)。我们的目的是比较小容量中心与大容量中心和使用其他方案的手术PMP患者的结果。材料和方法:回顾性分析了Jules bordt Institute - h.u.b在15年(2007年1月- 2021年12月)期间接受CRS + HIPEC(使用Elias高剂量奥沙利铂HIPEC方案)治疗的PMP患者。结果:纳入32例患者。病理结果:脱细胞粘蛋白21.9%,低分级34.4%,高分级43.7%。腹膜癌指数中位数为24(范围3-36)。中位随访时间为58个月。主要并发症(Clavien-Dindo III/IV)发生率为41%,术后死亡率为3%。平均无病生存期(DFS)估计为40 +/- 4个月(标准差(SD)),而总生存期(OS)为122 +/- 9个月(SD)。5年和10年DFS达到44.5%的平台期,OS分别为92.3%和76.2%。统计分析显示,低分级PMP可预测较好的DFS和OS (p = 0.0111和p = 0.0293)。我们还发现女性可以预测更好的DFS (p = 0.0262)。结论:我们的术后发病率和死亡率、DFS和OS与文献中报道的大容量PMP中心相似。我们的理论是,手术的熟练程度可以更多地归因于外科医生的CRS经验,而不管疾病的性质如何。
{"title":"Surgical management of pseudomyxoma peritonei: low-volume center experience.","authors":"Charif Khaled, Lina Safar, Alain Hendlisz, Maria Gomez Galdon, Paulus Kristanto, Michel Moreau, Ana Veron Sanchez, Gabriel Liberale","doi":"10.1080/00015458.2025.2510121","DOIUrl":"10.1080/00015458.2025.2510121","url":null,"abstract":"<p><strong>Introduction: </strong>Pseudomyxoma peritonei (PMP) is a rare disease characterized by diffuse peritoneal invasion of multifocal mucinous deposits. Gold standard treatment involves cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC). We aimed to compare the outcomes of operated PMP patients in a low-volume center, with those of high-volume centers and using other regimens.</p><p><strong>Materials and methods: </strong>Retrospective analysis was conducted for PMP patients treated by CRS + HIPEC (using the Elias high-dose Oxaliplatin HIPEC regimen) over a 15-year period (January 2007 - December 2021) at the Jules Bordet Institute - H.U.B.</p><p><strong>Results: </strong>32 patients were included. Pathology results were: 21.9% acellular mucin, 34.4% low-grade, and 43.7% high-grade. The median peritoneal cancer index was 24 (range 3-36). The median follow-up was 58 months. The rate of major complications (Clavien-Dindo III/IV) was 41% and postoperative mortality was 3%. Mean disease-free survival (DFS) was estimated at 40 +/- 4 months (standard deviation (SD)) while overall survival (OS) was 122 +/- 9 months (SD). DFS reached a plateau of 44.5% at 5 and 10 years and OS was 92.3% and 76.2% respectively. Statistical analysis showed low-grade PMP to be predictive of better DFS and OS (<i>p</i> = 0.0111 and <i>p</i> = 0.0293 respectively). We also found that female gender was predictive of better DFS (<i>p</i> = 0.0262).</p><p><strong>Conclusion: </strong>Our postoperative morbidity and mortality rates, DFS, and OS were similar to those reported in the literature for high-volume PMP centers. Our theory is that surgical proficiency can be more attributed to the surgeon's CRS experience, regardless of the nature of the disease.</p>","PeriodicalId":6935,"journal":{"name":"Acta Chirurgica Belgica","volume":" ","pages":"190-196"},"PeriodicalIF":0.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Downstaging and R0 resection of initially unresectable metastatic well-differentiated grade-3 pancreatic neuroendocrine tumor: a case report. 最初不可切除的转移性高分化3级胰腺神经内分泌肿瘤的降期和R0切除:1例报告。
IF 0.8 4区 医学 Q4 SURGERY Pub Date : 2025-08-01 Epub Date: 2025-06-06 DOI: 10.1080/00015458.2025.2515325
Arthur Houbiers, Joseph Weerts, Ghislain Houbiers, Roland Materne, Nancy Witvrouw, Noella Blétard, Benoit Monami, Christian Focan, Ivan Borbath

Introduction: High-grade pancreatic neuroendocrine tumors are rare, and most of them are well differentiated. Management of this type of tumor is not yet well established.

Methods: A 28-year-old woman was referred to our hospital for a well-differentiated grade-3 pancreatic neuroendocrine tumor with multiple liver metastases. The patient received neoadjuvant therapy consisting of combination of Capecitabine/Temozolomide chemotherapy and somatostatin analogue.

Results: An excellent regression was observed on both pancreatic and hepatic lesions, and therefore, an aggressive surgical management could be performed with a two-step scheme. Adjuvant hormono-chemotherapy was administered between the two surgeries. The patient achieved six years of disease-free survival following the last therapy.

Discussion and conclusion: We highlight the difference between well and poorly differentiated high-grade neuroendocrine neoplasia and report that aggressive surgery is a valid option even in metastatic presentation at diagnosis.

高级别胰腺神经内分泌肿瘤是一种罕见的肿瘤,大多数是分化良好的肿瘤。这种类型肿瘤的治疗尚未很好地建立。方法一例28岁女性患者因3级胰腺神经内分泌肿瘤伴多发肝转移而转诊至我院。患者接受卡培他滨/替莫唑胺联合生长抑素类似物的新辅助治疗。结果胰腺和肝脏病变均有良好的消退,因此可以采用两步方案进行积极的手术治疗。两次手术之间给予辅助激素化疗。在最后一次治疗后,患者达到了六年的无病生存期。讨论和结论我们强调分化良好和低分化的高级别神经内分泌瘤的区别,并报道即使在诊断时出现转移,积极手术也是一种有效的选择。
{"title":"Downstaging and R0 resection of initially unresectable metastatic well-differentiated grade-3 pancreatic neuroendocrine tumor: a case report.","authors":"Arthur Houbiers, Joseph Weerts, Ghislain Houbiers, Roland Materne, Nancy Witvrouw, Noella Blétard, Benoit Monami, Christian Focan, Ivan Borbath","doi":"10.1080/00015458.2025.2515325","DOIUrl":"10.1080/00015458.2025.2515325","url":null,"abstract":"<p><strong>Introduction: </strong>High-grade pancreatic neuroendocrine tumors are rare, and most of them are well differentiated. Management of this type of tumor is not yet well established.</p><p><strong>Methods: </strong>A 28-year-old woman was referred to our hospital for a well-differentiated grade-3 pancreatic neuroendocrine tumor with multiple liver metastases. The patient received neoadjuvant therapy consisting of combination of Capecitabine/Temozolomide chemotherapy and somatostatin analogue.</p><p><strong>Results: </strong>An excellent regression was observed on both pancreatic and hepatic lesions, and therefore, an aggressive surgical management could be performed with a two-step scheme. Adjuvant hormono-chemotherapy was administered between the two surgeries. The patient achieved six years of disease-free survival following the last therapy.</p><p><strong>Discussion and conclusion: </strong>We highlight the difference between well and poorly differentiated high-grade neuroendocrine neoplasia and report that aggressive surgery is a valid option even in metastatic presentation at diagnosis.</p>","PeriodicalId":6935,"journal":{"name":"Acta Chirurgica Belgica","volume":" ","pages":"215-221"},"PeriodicalIF":0.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144214525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adrenal cortical carcinoma - a case series and literature review of aggressive adrenal incidentalomas. 肾上腺皮质癌:侵袭性肾上腺偶发瘤的病例系列及文献回顾。
IF 0.8 4区 医学 Q4 SURGERY Pub Date : 2025-08-01 Epub Date: 2025-05-17 DOI: 10.1080/00015458.2025.2506935
Liesbeth Verlinde, Sam Kinet, Klaas Van Den Heede, Nele Brusselaers, Sam Van Slycke

Objective: Adrenal cortical carcinoma (ACC) is a rare and aggressive endocrine malignancy. Clinical symptoms are mainly related to excess hormone secretion. Hypercortisolism and virilisation are among the most common presentations.

Methods: We report a case series of five patients with ACC, three of which presented as adrenal incidentalomas. Additionally, a literature review on current diagnosis and management of ACC was performed.

Results: ACCs are often incidentally detected because of the liberal use of medical imaging. Management of ACC remains challenging, and the poor prognosis makes early diagnosis of crucial importance to increase chances of a better outcome. Biochemical evaluation should be performed to diagnose hormonally active tumours.

Conclusion: Surgery is the main and only potentially curative treatment option. Adjuvant treatment with mitotane may improve survival and is indicated for patients with a perceived high risk of recurrence. Aggressive cytotoxic therapy should be given to patients with an unfavourable prognosis.

目的:肾上腺皮质癌是一种罕见的侵袭性内分泌恶性肿瘤。临床症状主要与激素分泌过多有关。高皮质醇症和男性化是最常见的表现。方法:我们报告了5例ACC患者的病例系列,其中3例表现为肾上腺偶发瘤。此外,对目前ACC的诊断和治疗进行了文献综述。结果:由于医学影像学的广泛应用,acc经常被偶然发现。ACC的管理仍然具有挑战性,预后不良使得早期诊断对于增加获得更好结果的机会至关重要。诊断激素活性肿瘤时应进行生化评价。结论:手术是主要且唯一有治愈潜力的治疗方法。米托坦辅助治疗可提高生存率,适用于复发风险高的患者。对预后不良的患者应给予积极的细胞毒治疗。
{"title":"Adrenal cortical carcinoma - a case series and literature review of aggressive adrenal incidentalomas.","authors":"Liesbeth Verlinde, Sam Kinet, Klaas Van Den Heede, Nele Brusselaers, Sam Van Slycke","doi":"10.1080/00015458.2025.2506935","DOIUrl":"10.1080/00015458.2025.2506935","url":null,"abstract":"<p><strong>Objective: </strong>Adrenal cortical carcinoma (ACC) is a rare and aggressive endocrine malignancy. Clinical symptoms are mainly related to excess hormone secretion. Hypercortisolism and virilisation are among the most common presentations.</p><p><strong>Methods: </strong>We report a case series of five patients with ACC, three of which presented as adrenal incidentalomas. Additionally, a literature review on current diagnosis and management of ACC was performed.</p><p><strong>Results: </strong>ACCs are often incidentally detected because of the liberal use of medical imaging. Management of ACC remains challenging, and the poor prognosis makes early diagnosis of crucial importance to increase chances of a better outcome. Biochemical evaluation should be performed to diagnose hormonally active tumours.</p><p><strong>Conclusion: </strong>Surgery is the main and only potentially curative treatment option. Adjuvant treatment with mitotane may improve survival and is indicated for patients with a perceived high risk of recurrence. Aggressive cytotoxic therapy should be given to patients with an unfavourable prognosis.</p>","PeriodicalId":6935,"journal":{"name":"Acta Chirurgica Belgica","volume":" ","pages":"202-210"},"PeriodicalIF":0.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144075318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Plain versus drug-eluting balloon angioplasty in the treatment of non-thrombotic hemodialysis arteriovenous fistula stenosis: results from a single center comparative retrospective analysis. 普通与药物洗脱球囊血管成形术治疗非血栓性血液透析动静脉瘘狭窄:来自单中心比较回顾性分析的结果。
IF 0.8 4区 医学 Q4 SURGERY Pub Date : 2025-08-01 Epub Date: 2025-05-13 DOI: 10.1080/00015458.2025.2503647
Merve Horoz, Murat Yoğurtçu, Anıl Hüvez, Ömür Ballı, Serkan Gür

Purpose: To compare the mid-term primary and assisted-primary patency results of plain balloon angioplasty (PBA) versus drug-eluting balloon angioplasty (DEB) with non-thrombotic arteriovenous fistula (AVF) stenosis in hemodialysis (HD) patients.

Subject and methods: A total of 128 consecutive HD patients, who underwent endovascular treatment with DEB or PBA between October 2015 and December 2021, were investigated in this retrospective study. Color Doppler examination was performed for follow-up after 1, 3, 6, 12, 18, 24, and 36 months. Survival curves for primary and assisted primary vein patencies of the PTA and DEB group were generated with Kaplan-Meier survival analysis and were compared with the log-rank test.

Results: 78 patients (60.9%) underwent PBA (45 men, 33 women; mean age: 64.2 ± 13.9, range: 29-82 years) and 50 (39%) patients underwent DEB (36 men, 14 women; mean age: 65.6 ± 12.8, range: 28-87 years). The estimated primary patency rates at 6, 12,18, 24, and 36 months for the DEB group (95.5%, 92.8%, 88.6%, 77.1% and 54.0%, respectively) were significantly higher than those in the PBA group (84.5%, 76.9%, 73.9%, 66.4% and 59.0%, respectively) (p = .048). Assisted primary patency rates at 6, 12, 18, 24, and 36 months were higher in the DEB group (97.9%, 95.4%, 90.2%, 87.3% and 75.5%, respectively) than PBA group (94.7%, 86.9%, 85.0%, 78.0%, and 66.9%, respectively) but they were not statistically significant (p = .187).

Conclusion: Our study confirms DEB is a safe and effective treatment of dysfunctional AVF. We demonstrate higher primary patency rates in DEB than PBA at 6, 12, 18, 24 and 36 months. However, no statistically significant were detected between the two groups in mid-term follow-up.

目的:比较普通球囊成形术(PBA)与药物洗脱球囊成形术(DEB)对血液透析(HD)患者非血栓性动静脉瘘(AVF)狭窄的中期原发性和辅助原发性通畅效果。对象和方法:本回顾性研究共调查了2015年10月至2021年12月期间连续128例接受血管内DEB或PBA治疗的HD患者。随访1、3、6、12、18、24、36个月,行彩色多普勒检查。PTA组和DEB组原发和辅助原发静脉通畅的生存曲线采用Kaplan-Meier生存分析,并与log-rank检验进行比较。结果:78例(60.9%)患者接受了PBA(男性45例,女性33例;平均年龄:64.2±13.9岁,范围:29-82岁),50例(39%)患者接受了DEB(男性36例,女性14例;平均年龄:65.6±12.8岁,年龄范围:28 ~ 87岁。在6、12、18、24和36个月时,DEB组的原发性通畅率(分别为95.5%、92.8%、88.6%、77.1%和54.0%)显著高于PBA组(分别为84.5%、76.9%、73.9%、66.4%和59.0%)(p = 0.048)。6、12、18、24、36个月时,DEB组辅助原发性通畅率(分别为97.9%、95.4%、90.2%、87.3%、75.5%)高于PBA组(分别为94.7%、86.9%、85.0%、78.0%、66.9%),但差异无统计学意义(p = 0.187)。结论:我们的研究证实DEB是一种安全有效的治疗功能不全的AVF的方法。我们发现,在6、12、18、24和36个月时,DEB的原发性通畅率高于PBA。但在中期随访中,两组间差异无统计学意义。
{"title":"Plain versus drug-eluting balloon angioplasty in the treatment of non-thrombotic hemodialysis arteriovenous fistula stenosis: results from a single center comparative retrospective analysis.","authors":"Merve Horoz, Murat Yoğurtçu, Anıl Hüvez, Ömür Ballı, Serkan Gür","doi":"10.1080/00015458.2025.2503647","DOIUrl":"10.1080/00015458.2025.2503647","url":null,"abstract":"<p><strong>Purpose: </strong>To compare the mid-term primary and assisted-primary patency results of plain balloon angioplasty (PBA) versus drug-eluting balloon angioplasty (DEB) with non-thrombotic arteriovenous fistula (AVF) stenosis in hemodialysis (HD) patients.</p><p><strong>Subject and methods: </strong>A total of 128 consecutive HD patients, who underwent endovascular treatment with DEB or PBA between October 2015 and December 2021, were investigated in this retrospective study. Color Doppler examination was performed for follow-up after 1, 3, 6, 12, 18, 24, and 36 months. Survival curves for primary and assisted primary vein patencies of the PTA and DEB group were generated with Kaplan-Meier survival analysis and were compared with the log-rank test.</p><p><strong>Results: </strong>78 patients (60.9%) underwent PBA (45 men, 33 women; mean age: 64.2 ± 13.9, range: 29-82 years) and 50 (39%) patients underwent DEB (36 men, 14 women; mean age: 65.6 ± 12.8, range: 28-87 years). The estimated primary patency rates at 6, 12,18, 24, and 36 months for the DEB group (95.5%, 92.8%, 88.6%, 77.1% and 54.0%, respectively) were significantly higher than those in the PBA group (84.5%, 76.9%, 73.9%, 66.4% and 59.0%, respectively) (<i>p</i> = .048). Assisted primary patency rates at 6, 12, 18, 24, and 36 months were higher in the DEB group (97.9%, 95.4%, 90.2%, 87.3% and 75.5%, respectively) than PBA group (94.7%, 86.9%, 85.0%, 78.0%, and 66.9%, respectively) but they were not statistically significant (<i>p</i> = .187).</p><p><strong>Conclusion: </strong>Our study confirms DEB is a safe and effective treatment of dysfunctional AVF. We demonstrate higher primary patency rates in DEB than PBA at 6, 12, 18, 24 and 36 months. However, no statistically significant were detected between the two groups in mid-term follow-up.</p>","PeriodicalId":6935,"journal":{"name":"Acta Chirurgica Belgica","volume":" ","pages":"183-189"},"PeriodicalIF":0.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143957166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Post-esophagectomy aortogastric-tube fistula treated successfully with TEVAR: case report and review of the literature. TEVAR成功治疗食管切除术后主动脉胃管瘘1例报告及文献复习。
IF 0.6 4区 医学 Q4 SURGERY Pub Date : 2025-06-01 Epub Date: 2025-03-03 DOI: 10.1080/00015458.2025.2470535
Natasha Hasemaki, Dimitrios Schizas, Chrysovalantis Vergadis, Stavros Sougioultzis, Athanasios Katsargyris, Christos Klonaris

Background: Aortogastric-tube fistula is a rare but fatal complication of esophagectomy, most commonly induced by anastomotic leakage and peptic ulcer formation.

Methods: We report a rare case of a 55-year-old male patient presenting with an aortogastric-tube fistula located in the gastric conduit due to a recurrence of esophageal carcinoma.

Results: The patient was treated successfully with Thoracic Endovascular Aortic Repair (TEVAR) followed by esophageal stent placement to relieve dysphagia.

Conclusion: Although aortogastric-tube fistula is an extremely rare entity, the advent of esophageal cancer surgery, has led to the recognition of aortogastric-tube fistula with increasing frequency in the literature. Herein, we provide a comprehensive review of the literature, focusing on the pathophysiology, time interval between surgery and presentation, type of treatment and survival of reported cases with post-esophagectomy aortogastric-tube fistula.

背景:主动脉胃管瘘是食管切除术中一种罕见但致命的并发症,最常见的原因是吻合口漏和消化性溃疡的形成。方法:我们报告一例罕见的55岁男性患者,因食管癌复发而出现胃主动脉-胃管瘘。结果:经胸椎血管内主动脉瓣修复术(TEVAR)治疗,患者吞咽困难得到缓解。结论:虽然腹主胃管瘘是一种极为罕见的疾病,但随着食管癌手术的出现,使得文献对腹主胃管瘘的认识越来越频繁。在此,我们提供了一个全面的文献综述,重点是病理生理学,手术和表现之间的时间间隔,治疗类型和生存的病例报告食管切除术后主动脉胃管瘘。
{"title":"Post-esophagectomy aortogastric-tube fistula treated successfully with TEVAR: case report and review of the literature.","authors":"Natasha Hasemaki, Dimitrios Schizas, Chrysovalantis Vergadis, Stavros Sougioultzis, Athanasios Katsargyris, Christos Klonaris","doi":"10.1080/00015458.2025.2470535","DOIUrl":"10.1080/00015458.2025.2470535","url":null,"abstract":"<p><strong>Background: </strong>Aortogastric-tube fistula is a rare but fatal complication of esophagectomy, most commonly induced by anastomotic leakage and peptic ulcer formation.</p><p><strong>Methods: </strong>We report a rare case of a 55-year-old male patient presenting with an aortogastric-tube fistula located in the gastric conduit due to a recurrence of esophageal carcinoma.</p><p><strong>Results: </strong>The patient was treated successfully with Thoracic Endovascular Aortic Repair (TEVAR) followed by esophageal stent placement to relieve dysphagia.</p><p><strong>Conclusion: </strong>Although aortogastric-tube fistula is an extremely rare entity, the advent of esophageal cancer surgery, has led to the recognition of aortogastric-tube fistula with increasing frequency in the literature. Herein, we provide a comprehensive review of the literature, focusing on the pathophysiology, time interval between surgery and presentation, type of treatment and survival of reported cases with post-esophagectomy aortogastric-tube fistula.</p>","PeriodicalId":6935,"journal":{"name":"Acta Chirurgica Belgica","volume":" ","pages":"156-163"},"PeriodicalIF":0.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143466618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Acta Chirurgica Belgica
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