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Comparison of short‑term outcomes and 3-year overall survival between robotic and laparoscopic gastrectomy for gastric cancer: a propensity score matching analysis. 胃癌机器人和腹腔镜胃切除术的短期疗效和 3 年总生存率比较:倾向得分匹配分析
IF 0.6 4区 医学 Q4 SURGERY Pub Date : 2024-12-01 Epub Date: 2024-05-11 DOI: 10.1080/00015458.2024.2348256
Li Zhang, Jingli Cui, Mingzhi Cai, Bin Li, Gang Ma, Xuejun Wang, Yong Liu, Jingyu Deng, Rupeng Zhang, Han Liang, Jilong Yang

Background: Despite the increasing use of robotic gastrectomy (RG) as an alternative to laparoscopic gastrectomy (LG) in treating gastric cancer, controversy remains over the advantages of RG compared to LG and there is a paucity of studies comparing the two techniques regarding patient survival.

Methods: In this retrospective cohort study, 675 patients undergoing minimally invasive gastrectomy were recruited from January 2016 to January 2018 (LG: n = 567; RG: n = 108). A one-to-one propensity score matching (PSM) analysis was applied to minimize the selection bias due to confounding factors, yielding 104 patients in each of the RG and LG groups. After matching, the short-term outcomes and 3-year overall survival were compared in the two groups.

Results: The PSM cohort analysis showed a similar 3-year overall survival between RG and LG groups (p = .249). Concerning the short-term outcomes, the RG compared to LG resulted in lower blood loss (p = .01), lower postoperative complications (p = .001), lower postoperative pain (p = .016), earlier initiation of soft diet (p = .011), shorter hospital stay ‌(p = .012), but higher hospitalization expenses (p = .001).

Conclusion: Our findings suggest that RG may offer advantages in terms of blood loss, surgical complications, recovery time, and pain management compared to LG while maintaining similar overall survival rates. However, RG is associated with higher hospital costs, potentially limiting its wider adoption. Further research, including large, multi-center randomized controlled trials with longer patient follow-up, particularly for advanced gastric cancer, is needed to confirm these findings.

背景:尽管越来越多地使用机器人胃切除术(RG)替代腹腔镜胃切除术(LG)治疗胃癌,但关于机器人胃切除术与腹腔镜胃切除术相比的优势仍存在争议,而且关于两种技术在患者生存率方面的比较研究也很少:在这项回顾性队列研究中,从2016年1月至2018年1月招募了675名接受微创胃切除术的患者(LG:n = 567;RG:n = 108)。为尽量减少混杂因素导致的选择偏差,研究采用了一对一倾向得分匹配分析,结果RG组和LG组各有104名患者。匹配后,比较了两组患者的短期疗效和 3 年总生存率:倾向得分匹配队列分析显示,RG 组和 LG 组的三年总生存率相似(P = 0.249)。在短期结果方面,RG 组与 LG 组相比,失血量更少(P = 0.01),术后并发症更少(P = 0.001),术后疼痛更轻(P = 0.016),更早开始软食(P = 0.011),住院时间更短(P = 0.012),但住院费用更高(P = 0.001):我们的研究结果表明,与 LG 相比,RG 可在失血量、手术并发症、恢复时间和疼痛控制方面提供优势,同时保持相似的总体存活率。然而,RG 与较高的住院费用相关,可能会限制其更广泛的应用。要证实这些发现,还需要进一步的研究,包括对患者进行更长时间随访的大型多中心随机对照试验,尤其是针对晚期胃癌的试验。
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引用次数: 0
Is Uniportal-VATS a feasible approach for pericardial cyst treatment? Comment on: "A case series: Uniportal VATS excision of pericardial cyst in symptomatic patients". 致编辑的信:单孔VATS治疗心包囊肿可行吗?评论"一个病例系列:无症状患者的单孔 VATS 心包囊肿切除术 "的评论。
IF 0.6 4区 医学 Q4 SURGERY Pub Date : 2024-11-19 DOI: 10.1080/00015458.2024.2430070
Antonio Giulio Napolitano, Dania Nachira, Adriana Nocera, Claudia Bellettati, Maria Letizia Vita, Stefano Margaritora
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引用次数: 0
A case report of a mesenteric cystic lymphangioma in a young adult woman presenting to the emergency room. 一例急诊室就诊的年轻成年女性肠系膜囊性淋巴管瘤病例报告。
IF 0.6 4区 医学 Q4 SURGERY Pub Date : 2024-11-11 DOI: 10.1080/00015458.2024.2424046
L C A van der Broeck, S H J Ketelaers, J G Bloemen

Background: Mesenteric cystic lymphangiomas (MCLs) are rare benign tumours seen in adults. The clinical presentation may vary from asymptomatic to acute abdominal pain with inexplicable abdominal pain, nausea and vomiting.

Case presentation: In the current case report, a 22-year old, healthy women presented to the emergency room with acute abdominal pain in need of urgent surgical exploration. Histopathological examination revealed an mesenteric cystic lymphangioma.

Conclusion: In patients with inexplicable abdominal pain, the suspicion of MCLs and proper diagnostic strategies are important. The primary treatment of MCLs consists of radical surgical resection to prevent invasion in surrounding tissue. Tertiary referral centres should be consulted to support in the diagnosis, treatment and follow-up of MCLs.

背景肠管囊性淋巴管瘤(MCL)是一种罕见的成人良性肿瘤。本病例报告中,一名 22 岁的健康女性因急性腹痛到急诊就诊,急需手术治疗。组织病理学检查显示该患者患有肠系膜囊性淋巴管瘤。结论在莫名腹痛的患者中,怀疑肠系膜囊性淋巴管瘤并采取正确的诊断策略非常重要。MCLs 的主要治疗方法包括根治性手术切除,以防止周围组织受侵。应咨询三级转诊中心,以便为 MCL 的诊断、治疗和随访提供支持。
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引用次数: 0
Spontaneous splenic rupture two days after laparoscopic sleeve gastrectomy. 腹腔镜袖状胃切除术两天后自发性脾破裂。
IF 0.6 4区 医学 Q4 SURGERY Pub Date : 2024-11-06 DOI: 10.1080/00015458.2024.2424047
M Mertens, L Verheyen, J Ceulemans

Introduction: Sleeve gastrectomy is a common bariatric procedure to manage morbid obesity. Splenic injury such as splenic rupture after sleeve gastrectomy is a rare complication which can be treated both with a splenectomy or conservative approach, called spleen-preserving surgery.

Patients and methods: A 42-year old male, in whom we performed a sleeve gastrectomy, presented with splenic rupture, within 48 h postoperative, for which spleen-preserving surgery was performed. As splenic rupture is a very rare complication, we performed an extensive literature search in the PubMed database. After obtaining patient informed consent, we aim to describe a sixth presentation of this rare surgical complication.

Result: To the best of our knowledge, only five cases of splenic rupture after laparoscopic sleeve gastrectomy have been described before, all treated with a splenectomy. Furthermore, we are the first to describe spleen-preserving surgery.

Conclusion: We present the sixth case of spontaneous splenic rupture after laparoscopic sleeve gastrectomy, and the first to treat it with spleen-preserving surgery.

导言袖状胃切除术是控制病态肥胖的常见减肥手术。袖状胃切除术后脾损伤(如脾破裂)是一种罕见的并发症,可通过脾切除术或称为保脾手术的保守方法进行治疗。患者和方法一名 42 岁的男性接受了袖状胃切除术,术后 48 小时内出现脾破裂,为此我们进行了保脾手术。由于脾破裂是一种非常罕见的并发症,我们在 PubMed 数据库中进行了广泛的文献检索。据我们所知,此前仅有五例腹腔镜袖带胃切除术后脾破裂的病例,均采用脾切除术治疗。此外,我们还是首例描述保脾手术的患者。结论我们介绍了第六例腹腔镜袖带胃切除术后自发性脾破裂的病例,也是首例采用保脾手术治疗的病例。
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引用次数: 0
The Hellenic surgical School for treatment of neuralgias and dystonias as presented in 19th-20th centuries in Greece. 19-20 世纪希腊治疗神经痛和肌张力障碍的外科学校。
IF 0.6 4区 医学 Q4 SURGERY Pub Date : 2024-11-03 DOI: 10.1080/00015458.2024.2424038
Konstantinos Laios, Pavlos Lytsikas-Sarlis, Evangelia Mourellou, Constantinos G Zografos, Gregory Tsoucalas, Marianna Karamanou, Georgios Androutsos

Background: This article examines the surgical techniques used for the treatment of neuralgia and dystonia in Greece during the late 19th to the middle of the twentieth century. It emphasizes on the Greek contribution to neurosurgery.

Methods: The aim of this study is achieved by examining unpublished archives as well as historical documents collected from both the National Library of Greece and the Library of the Hellenic Parliament.

Results: Greek medicine of the nineteenth century emerged through the practice of Greek physicians who have studied abroad. Many important figures on surgery, like Theodoros Aretaios, Nikolaos Taptas and Konstantinos Mermigas attempted myotomies, neurectomies, trasoraphies, and injections according the European protocols, though introducing some variants on well established procedures. This article also refers to the early stereotactic neurosurgery in Greece, especially in the treatment of Parkinson's Disease and extrapyramidal syndromes by Aggelos Karakalos, ultimately contributing toward a better understanding of the evolution of Greek surgery, highlighting its pivotal role in the international development of neurosurgical techniques. Greek school of surgery avoided brutal operations like trephination and proved worthy among most advanced school of the 19th and 20th centuries.

Conclusion: Neuralgias and dystonias constituted for the physicians of the past a riddle connected with the mystery of the central and peripheral neural system. Surgical procedures were proposed, finding ways of implication mainly in the cases of neuralgias. Gradually drug administration of simple substances like alcohol demonstrated some results. The study of Greek medical archives dated back to 19th and early twentieth century allow us to have a comprehensive idea about the therapeutical approaches and especially the operative ones used by the Greek physicians of the time to fight dystonias and neuralgias unveiling their capabilities and theoretical medical knowledge.

背景:本文研究了19世纪末至20世纪中叶希腊用于治疗神经痛和肌张力障碍的外科技术。文章强调了希腊对神经外科的贡献:本研究的目的是通过研究未出版的档案以及从希腊国家图书馆和希腊议会图书馆收集的历史文献来实现的:结果:19 世纪的希腊医学是通过在国外学习过的希腊医生的实践产生的。许多外科领域的重要人物,如 Theodoros Aretaios、Nikolaos Taptas 和 Konstantinos Mermigas,都尝试按照欧洲规程进行肌瘤切除术、神经切除术、截肢术和注射,但也对一些成熟的手术方法进行了改良。本文还介绍了希腊早期的立体定向神经外科,特别是阿吉洛斯-卡拉卡洛斯(Aggelos Karakalos)在治疗帕金森病和锥体外系综合征方面的成就,最终有助于更好地了解希腊外科的发展历程,突出其在国际神经外科技术发展中的关键作用。希腊外科学派避免了截骨术等残忍的手术,被证明是 19 世纪和 20 世纪最先进的外科学派之一:对于过去的医生来说,神经痛和肌张力障碍是一个与中枢和外周神经系统的奥秘有关的谜。人们提出了手术治疗方法,主要针对神经痛病例。渐渐地,使用酒精等简单物质进行药物治疗也取得了一些效果。通过对 19 世纪和 20 世纪初希腊医学档案的研究,我们可以全面了解当时希腊医生在治疗肌张力障碍和神经痛方面所采用的治疗方法,特别是手术方法,从而揭示他们的能力和医学理论知识。
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引用次数: 0
Two-staged repair of a giant iliac aneurysm and open repair of a true deep femoral artery aneurysm in Loeys-Dietz syndrome type V: a case report and review of literature. Loeys-Dietz 综合征 V 型巨大髂动脉瘤的两阶段修复术和真正股深动脉瘤的开放式修复术:病例报告和文献综述。
IF 0.6 4区 医学 Q4 SURGERY Pub Date : 2024-11-01 DOI: 10.1080/00015458.2024.2420422
Annefleur Mauritz, Karen Van Langenhove, Stijn Van Wiemeersch, Lieven Dedrye, Anneleen Verbrugghe, Stephan Ceuppens

Background: The syndrome of Loeys-Dietz (LDS) is a rare connective tissue disorder. A classic triad of symptoms is seen: hypertelorism, atypical uvula or clef palate, and multiple tortuous arteries and aneurysms of the aorta and main arterial branches. Mutations in genes involving the transforming growth factor-beta (TGFB) signaling pathway are the cause of this syndrome. There are six subtypes of LDS, categorized based on the gene mutation that is involved. LDS type V and VI, concerning the TGFB3 and SMAD2 gene respectively, are the two subtypes that are least frequently seen. Mostly, in the patients with LDS type V non-cardiovascular symptoms are most prominent and there is a lower prevalence of vascular abnormalities.

Methods and results: This case report illustrates extensive vascular disease in Loeys-Dietz syndrome type V. We present open repair of a true deep femoral artery aneurysm and two-staged repair of a giant common iliac aneurysm with coiling of an ipsilateral internal iliac artery aneurysm and subsequent endovascular aortic repair (EVAR).

Conclusion: Loeys-Dietz syndrome type V is a rare connective tissue disorder, that was thought to have non-cardiovascular symptoms at the forefront. However, this case represents multiple vascular abnormalities, including arterial tortuosity and iliac and femoral artery aneurysms, as the main symptom in LDS type V, presents our multi-stage treatment and discusses the different therapeutic strategies.

背景:洛伊-迪茨综合征(LDS)是一种罕见的结缔组织疾病。患者会出现典型的三联症状:脊柱肥大、非典型悬雍垂或裂腭,以及主动脉和主要动脉分支的多发性迂曲动脉和动脉瘤。涉及转化生长因子-β(TGFB)信号通路的基因突变是该综合征的病因。LDS 有六种亚型,根据涉及的基因突变进行分类。LDS V 型和 VI 型分别与 TGFB3 和 SMAD2 基因有关,是最不常见的两种亚型。大多数 LDS V 型患者的非心血管症状最为突出,血管异常的发病率较低:本病例报告说明了 Loeys-Dietz 综合征 V 型的广泛血管疾病。我们对一个真正的股深动脉瘤进行了开放式修复,对一个巨大的髂总动脉瘤进行了两阶段修复,并对同侧的髂内动脉瘤进行了卷曲,随后进行了主动脉血管内修复(EVAR):结论:Loeys-Dietz 综合征 V 型是一种罕见的结缔组织疾病,以往认为该病主要表现为非心血管症状。然而,本病例代表了多种血管异常,包括动脉迂曲、髂动脉和股动脉瘤,这些是 LDS V 型的主要症状,我们的多阶段治疗并讨论了不同的治疗策略。
{"title":"Two-staged repair of a giant iliac aneurysm and open repair of a true deep femoral artery aneurysm in Loeys-Dietz syndrome type V: a case report and review of literature.","authors":"Annefleur Mauritz, Karen Van Langenhove, Stijn Van Wiemeersch, Lieven Dedrye, Anneleen Verbrugghe, Stephan Ceuppens","doi":"10.1080/00015458.2024.2420422","DOIUrl":"10.1080/00015458.2024.2420422","url":null,"abstract":"<p><strong>Background: </strong>The syndrome of Loeys-Dietz (LDS) is a rare connective tissue disorder. A classic triad of symptoms is seen: hypertelorism, atypical uvula or clef palate, and multiple tortuous arteries and aneurysms of the aorta and main arterial branches. Mutations in genes involving the transforming growth factor-beta (TGFB) signaling pathway are the cause of this syndrome. There are six subtypes of LDS, categorized based on the gene mutation that is involved. LDS type V and VI, concerning the TGFB3 and SMAD2 gene respectively, are the two subtypes that are least frequently seen. Mostly, in the patients with LDS type V non-cardiovascular symptoms are most prominent and there is a lower prevalence of vascular abnormalities.</p><p><strong>Methods and results: </strong>This case report illustrates extensive vascular disease in Loeys-Dietz syndrome type V. We present open repair of a true deep femoral artery aneurysm and two-staged repair of a giant common iliac aneurysm with coiling of an ipsilateral internal iliac artery aneurysm and subsequent endovascular aortic repair (EVAR).</p><p><strong>Conclusion: </strong>Loeys-Dietz syndrome type V is a rare connective tissue disorder, that was thought to have non-cardiovascular symptoms at the forefront. However, this case represents multiple vascular abnormalities, including arterial tortuosity and iliac and femoral artery aneurysms, as the main symptom in LDS type V, presents our multi-stage treatment and discusses the different therapeutic strategies.</p>","PeriodicalId":6935,"journal":{"name":"Acta Chirurgica Belgica","volume":" ","pages":"1-9"},"PeriodicalIF":0.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142492674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Thoracic aortic coarctation with asbestos-induced pleural fibrosis presenting as lower limb claudication. 胸主动脉闭塞症伴有石棉诱发的胸膜纤维化,表现为下肢跛行。
IF 0.6 4区 医学 Q4 SURGERY Pub Date : 2024-10-26 DOI: 10.1080/00015458.2024.2418150
Kerbi Alejandro Guevara-Noriega, Raquel Chavez-Abiega, Vladimir Cheranovskiy, Teresa Solanich Valldaura

Asbestos exposure is a well-documented cause of pulmonary diseases. However, its systemic effects, particularly on the cardiovascular system, are less understood. We expose a case that highlights an unusual cardiovascular manifestation in a patient with a history of pleural asbestosis compressing the aorta and clinically manifested as lower limb claudication. A 65-year-old individual presented with bilateral short-distance lower extremity claudication. The patient's clinical presentation prompted advanced imaging studies, including CT angiography, to assess the extent of vascular involvement. The imaging confirmed the presence of substantial calcification and narrowing of the thoracic aorta. The patient had a documented history of pleural asbestosis. This case underscores the potential for asbestos-related diseases to extend beyond pulmonary manifestations, affecting cardiovascular health. The observed aortic calcification and coarctation represent an atypical progression of asbestosis related pathology.

暴露于石棉是导致肺部疾病的一个证据确凿的原因。然而,人们对石棉的全身性影响,尤其是对心血管系统的影响了解较少。我们揭露了一个病例,该病例强调了一名有胸膜石棉沉着病史的患者的不寻常心血管表现,该病压迫主动脉,临床表现为下肢跛行。一名 65 岁的患者出现双侧下肢短距离跛行。患者的临床表现促使其接受包括 CT 血管造影在内的高级影像学检查,以评估血管受累的程度。造影证实胸主动脉存在大量钙化和狭窄。患者有胸膜石棉沉滞症病史记录。该病例突出表明,与石棉相关的疾病有可能超越肺部表现,影响心血管健康。观察到的主动脉钙化和闭塞代表了石棉沉滞症相关病理的非典型进展。
{"title":"Thoracic aortic coarctation with asbestos-induced pleural fibrosis presenting as lower limb claudication.","authors":"Kerbi Alejandro Guevara-Noriega, Raquel Chavez-Abiega, Vladimir Cheranovskiy, Teresa Solanich Valldaura","doi":"10.1080/00015458.2024.2418150","DOIUrl":"https://doi.org/10.1080/00015458.2024.2418150","url":null,"abstract":"<p><p>Asbestos exposure is a well-documented cause of pulmonary diseases. However, its systemic effects, particularly on the cardiovascular system, are less understood. We expose a case that highlights an unusual cardiovascular manifestation in a patient with a history of pleural asbestosis compressing the aorta and clinically manifested as lower limb claudication. A 65-year-old individual presented with bilateral short-distance lower extremity claudication. The patient's clinical presentation prompted advanced imaging studies, including CT angiography, to assess the extent of vascular involvement. The imaging confirmed the presence of substantial calcification and narrowing of the thoracic aorta. The patient had a documented history of pleural asbestosis. This case underscores the potential for asbestos-related diseases to extend beyond pulmonary manifestations, affecting cardiovascular health. The observed aortic calcification and coarctation represent an atypical progression of asbestosis related pathology.</p>","PeriodicalId":6935,"journal":{"name":"Acta Chirurgica Belgica","volume":" ","pages":"1-2"},"PeriodicalIF":0.6,"publicationDate":"2024-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142492673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Congenital diaphragmatic hernia with intrathoracic kidney: case report, review of the literature, and strategy for treatment in neonates and infants. 先天性膈疝伴胸内肾:病例报告、文献综述及新生儿和婴儿治疗策略。
IF 0.6 4区 医学 Q4 SURGERY Pub Date : 2024-10-24 DOI: 10.1080/00015458.2024.2419705
Yannick Vancampenhout, Stijn Heyman, Daphne Arnold, Stefanie Devriendt, Dirk Vervloessem

Background: Congenital diaphragmatic hernia (CDH) is a rare developmental defect in the diaphragm, occurring in 2 in 10,000 births. Herniation of intraperitoneal organs through the diaphragmatic opening is always present, however few cases mention the herniation of retroperitoneal organs, such as a kidney. Due to the rarity of this condition, the optimal treatment strategy remains unclear.

Methods: A PubMed search was conducted, gathering all published reports of CDH with intrathoracic herniation of the kidney. Cases of isolated intrathoracic kidney without CDH and cases of traumatic hernia were excluded. Patients who underwent surgical repair before the age of 5 years were included for further analysis.

Results: Thirty-seven cases were found from 1970 to 2022. The approach used for surgical repair was not mentioned in 55.6% of cases. 52.9% of the remaining patients were treated through laparotomy, whereas in 23.5% a thoracoscopy was performed. A primary repair of the hernia was performed in 88.6%. A hernia sac was noted in 70%. Most patients had a normal origin of the renal vessels and reduction of the intrathoracic kidney was achieved in 78.8%. Moreover, we report a case of CDH with intrathoracic kidney treated through thoracoscopic repair.

Conclusion: A thoracoscopic approach is effective for the treatment of CDH with an intrathoracic kidney case with an associated intrathoracic kidney. A therapeutic strategy for CDH with intrathoracic kidney is suggested based on data from published cases.

背景:先天性膈疝(CDH)是一种罕见的膈肌发育缺陷,每 10,000 名新生儿中就有 2 例。腹腔内脏器通过膈肌开口疝出的情况时有发生,但很少有病例提及腹膜后脏器(如肾脏)疝出。由于这种情况非常罕见,最佳治疗策略仍不明确:方法:我们在 PubMed 上进行了搜索,收集了所有已发表的关于 CDH 伴有胸腔内肾脏疝的报道。排除了无 CDH 的孤立胸腔内肾脏病例和外伤性疝气病例。进一步分析还包括 5 岁前接受手术修复的患者:结果:1970-2022 年间共发现 37 例病例。55.6%的病例未提及手术修补的方法。其余 52.9% 的患者通过开腹手术治疗,23.5% 的患者通过胸腔镜手术治疗。88.6%的患者进行了疝气的初次修补。70%的患者有疝囊。大多数患者的肾血管起源正常,78.8%的患者实现了胸内肾缩小。此外,我们还报告了一例通过胸腔镜修补术治疗伴有胸内肾的 CDH 病例:结论:胸腔镜方法是治疗伴有胸腔内肾脏的 CDH 的有效方法。根据已发表病例的数据,提出了胸内肾CDH的治疗策略。
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引用次数: 0
In Memoriam. 悼念 Toon De Backer 博士教授。
IF 0.6 4区 医学 Q4 SURGERY Pub Date : 2024-10-23 DOI: 10.1080/00015458.2024.2419206
Charlotte Vercauteren
{"title":"In Memoriam.","authors":"Charlotte Vercauteren","doi":"10.1080/00015458.2024.2419206","DOIUrl":"10.1080/00015458.2024.2419206","url":null,"abstract":"","PeriodicalId":6935,"journal":{"name":"Acta Chirurgica Belgica","volume":" ","pages":"1-2"},"PeriodicalIF":0.6,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142455426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Survival difference between patients with single versus multiple metastatic lymph nodes and the role of histology in pathological stage II-N1 non-small cell lung cancer. 病理分期为 II-N1 期的非小细胞肺癌中,单个转移淋巴结与多个转移淋巴结患者的生存率差异以及组织学的作用。
IF 0.6 4区 医学 Q4 SURGERY Pub Date : 2024-10-01 Epub Date: 2024-02-28 DOI: 10.1080/00015458.2024.2322243
Julianne Ruiter, Adrianus de Langen, Kim Monkhorst, Alexander Veenhof, Houke Klomp, Jasper Smit, Egbert Smit, Ronald Damhuis, Koen Hartemink

Background: Previous studies investigating whether metastatic lymph node count is a relevant prognostic factor in pathological N1 non-small cell lung cancer (NSCLC), showed conflicting results. Hypothesizing that outcome may also be related to histological features, we determined the prognostic impact of single versus multiple metastatic lymph nodes in different histological subtypes for patients with stage II-N1 NSCLC.

Methods: We performed a retrospective cohort study using data from the Netherlands Cancer Registry, including patients treated with a surgical resection for stage II-N1 NSCLC (TNM 7th edition) in 2010-2016. Overall survival (OS) was assessed for patients with single (pN1a) and multiple (pN1b) metastatic nodes. Using multivariable analysis, we compared OS between pN1a and pN1b in different histological subtypes.

Results: After complete resection of histologically proven stage II-N1 NSCLC, 1309 patients were analyzed, comprising 871 patients with pN1a and 438 with pN1b. The median number of pathologically examined nodes (N1 + N2) was 9 (interquartile range 6-13). Five-year OS was 53% for pN1a versus 51% for pN1b. In multivariable analysis, OS was significantly different between pN1a and pN1b (HR 1.19, 95% CI 1.01-1.40). When stratifying for histology, the prognostic impact of pN1a/b was only observed in adenocarcinoma patients (HR 1.44, 95% CI 1.15-1.81).

Conclusion: Among patients with stage II-N1 adenocarcinoma, the presence of multiple metastatic nodes had a significant impact on survival, which was not observed for other histological subtypes. If further refinement as to lymph node count will be considered for incorporation into a new staging system, evaluation of the role of histology is recommended.

背景:以前的研究调查了转移淋巴结数量是否是病理 N1 非小细胞肺癌(NSCLC)的相关预后因素,结果相互矛盾。我们推测预后也可能与组织学特征有关,因此确定了不同组织学亚型的单个与多个转移淋巴结对 II-N1 期 NSCLC 患者预后的影响:我们利用荷兰癌症登记处(Netherlands Cancer Registry)的数据开展了一项回顾性队列研究,研究对象包括2010-2016年接受手术切除治疗的II-N1期NSCLC(TNM第7版)患者。我们评估了单个(pN1a)和多个(pN1b)转移性结节患者的总生存期(OS)。通过多变量分析,我们比较了不同组织学亚型中pN1a和pN1b的OS:在对组织学证实的II-N1期NSCLC患者进行完全切除后,我们对1309名患者进行了分析,其中包括871名pN1a患者和438名pN1b患者。病理检查结节(N1 + N2)的中位数为9个(四分位间范围为6-13)。pN1a患者的5年OS为53%,pN1b患者为51%。在多变量分析中,pN1a 和 pN1b 的 OS 显著不同(HR 1.19,95% CI 1.01-1.40)。在对组织学进行分层时,仅在腺癌患者中观察到pN1a/b对预后的影响(HR 1.44,95% CI 1.15-1.81):结论:在II-N1期腺癌患者中,存在多个转移淋巴结对生存有显著影响,而在其他组织学亚型中则没有观察到这种影响。如果考虑在新的分期系统中进一步完善淋巴结计数,建议对组织学的作用进行评估。
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引用次数: 0
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Acta Chirurgica Belgica
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