Acta dermato-venereologica最新文献

Notalgia paresthetica (NP) is a sensory neuropathy characterized by itching and hyperpigmentation, typically around the scapular region. This study aimed to investigate the relationships between clinical findings, radiological features, and central sensitization (CS) in NP patients. This cross-sectional study included 45 NP patients and 45 age- and gender-matched healthy controls. Neuropathic symptoms were assessed using the painDETECT questionnaire (PD-Q), while CS symptoms were evaluated with the Central Sensitization Inventory (CSI). Pain and pruritus severity were evaluated using a Visual Analogue Scale (VAS). Cervical-thoracic vertebral pathologies were examined via 2-view X-rays. Vertebral degeneration was observed in 75.5% of NP patients, which was significantly higher than in controls (p = 0.001). CS was present in 48.9% of NP patients, also significantly higher than in the control group (p = 0.020). A higher rate of prior fibromyalgia diagnosis, based on CSI-B responses, was found in NP patients (p = 0.05). NP patients with CS had significantly higher VAS pain scores (p < 0.001), PD-Q scores (p = 0.005), and vertebral degeneration rates (p = 0.001) compared with those without CS. Additionally, 63.6% of NP patients with CS had lesions in multiple vertebral regions (p = 0.002). CS is common in NP patients, especially in those with vertebral degeneration. Multidisciplinary evaluation considering CS status may improve management of NP.

Abstracts from 15th Georg Rajka International Symposium on Atopic Dermatitis.

Contact urticaria syndrome, encompassing immunological contact urticaria and protein contact dermatitis, comprises immediate cutaneous reactions with potential systemic manifestations, including anaphylaxis. These conditions are frequently underdiagnosed despite their significant occupational impact. This study aimed to evaluate the clinical and laboratory features associated with distinct phenotypes of contact urticaria syndrome. A retrospective, observational analysis was performed at Hospital del Mar (Barcelona) from January 2010 to January 2024, including adult patients diagnosed with immunological contact urticaria and/or protein contact dermatitis and a positive prick test. Demographic data, clinical data, and complementary test results, including culprit agents, were compared between patients with isolated contact urticaria and those with protein contact dermatitis. A total of 95 patients were included. Results indicated that isolated contact urticaria was more frequently associated with facial involvement (n = 19, 28.8%) and a higher rate of systemic reactions (n = 18, 27.3%), including anaphylaxis, whereas protein contact dermatitis was frequently occupational-related (n = 19, 65.5%), and with a trend toward higher atopic dermatitis comorbidity (n = 12, 41.4%). These findings emphasize the heterogeneity of contact urticaria syndrome and underscore the importance of comprehensive clinical evaluation for effective diagnosis and management.

Molluscum contagiosum (MC) is a common paediatric cutaneous infection caused by a DNA poxvirus, resulting in lesions that often impair patients' quality of life. Although MC typically resolves spontaneously, parents frequently seek treatment due to cosmetic concerns, pruritus, or fear of lesion spread. Currently, there is no gold standard treatment, and various therapeutic modalities - including curettage and electrodessication (ED) - are utilized in clinical practice. This prospective comparative study aimed to compare efficacy, cosmetic outcome, and patient satisfaction with curettage vs ED as treatment methods in the treatment of MC. The study included 103 paediatric patients presenting with confirmed MC and ≥ 10 lesions (or 5 on face), treated at Sheba Medical Center. Treatment allocation to either curettage or ED was based on guardian preference. Data collected included demographic and clinical characteristics, procedural outcomes, pain levels, and satisfaction ratings. Structured questionnaires were administered 6 weeks post-procedure to evaluate outcomes, including lesion recurrence, infection, remnants, healing duration, and patient/parent satisfaction. Statistical analyses were conducted, with statistical significance defined as p ≤ 0.05. Among the cohort (mean age, 4.37 years; 60% female), 67 (61.7%) patients were treated with curettage and 42 (38.3%) with ED. Most presented with facial lesions (67.96%) and multiple lesion sites (50.5%). Patients treated with curettage reported fewer remnants (42.9% vs 70%, p = 0.007), greater aesthetic satisfaction (p = 0.039), and faster recovery (p = 0.050). Pain levels were comparable between groups, but higher 1-week post-procedure in ED (p = 0.014). Recurrence rates were similar for both methods (49.2% curettage, 35% ED). Curettage offers clear advantages over ED for the treatment of MC, resulting in superior aesthetic outcomes, faster recovery, and lower post-procedural pain. Therefore, curettage should generally be preferred, while ED may be considered for precise interventions in sensitive anatomical areas.