首页 > 最新文献

智能学习系统与应用(英文)最新文献

英文 中文
Application of Artificial Intelligence Algorithm in Image Processing for Cattle Disease Diagnosis 人工智能算法在牛疾病诊断图像处理中的应用
Pub Date : 2022-01-01 DOI: 10.4236/jilsa.2022.144006
Bezawit Lake, Fekade Getahun, Fitsum T. Teshome
{"title":"Application of Artificial Intelligence Algorithm in Image Processing for Cattle Disease Diagnosis","authors":"Bezawit Lake, Fekade Getahun, Fitsum T. Teshome","doi":"10.4236/jilsa.2022.144006","DOIUrl":"https://doi.org/10.4236/jilsa.2022.144006","url":null,"abstract":"","PeriodicalId":69452,"journal":{"name":"智能学习系统与应用(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70330690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Gamification in Education: A Study of Design-Based Learning in Operationalizing a Game Studio for Serious Games 教育中的游戏化:基于设计的学习在严肃游戏工作室运作中的研究
Pub Date : 2022-01-01 DOI: 10.4236/jilsa.2022.144010
James Hutson, Ben Fulcher, Joseph Weber
{"title":"Gamification in Education: A Study of Design-Based Learning in Operationalizing a Game Studio for Serious Games","authors":"James Hutson, Ben Fulcher, Joseph Weber","doi":"10.4236/jilsa.2022.144010","DOIUrl":"https://doi.org/10.4236/jilsa.2022.144010","url":null,"abstract":"","PeriodicalId":69452,"journal":{"name":"智能学习系统与应用(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70330790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Virtual Reality and Learning: A Case Study of Experiential Pedagogy in Art History 虚拟现实与学习:艺术史中体验教学法的个案研究
Pub Date : 2022-01-01 DOI: 10.4236/jilsa.2022.144005
James Hutson, Trent Olsen
{"title":"Virtual Reality and Learning: A Case Study of Experiential Pedagogy in Art History","authors":"James Hutson, Trent Olsen","doi":"10.4236/jilsa.2022.144005","DOIUrl":"https://doi.org/10.4236/jilsa.2022.144005","url":null,"abstract":"","PeriodicalId":69452,"journal":{"name":"智能学习系统与应用(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70330649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Digital Biomarker Identification for Parkinson’s Disease Using a Game-Based Approach 基于游戏方法的帕金森病数字生物标志物鉴定
Pub Date : 2022-01-01 DOI: 10.4236/jilsa.2022.144007
Ilman Shazhaev, Dimitry Mihaylov, Abdulla Shafeeg
{"title":"Digital Biomarker Identification for Parkinson’s Disease Using a Game-Based Approach","authors":"Ilman Shazhaev, Dimitry Mihaylov, Abdulla Shafeeg","doi":"10.4236/jilsa.2022.144007","DOIUrl":"https://doi.org/10.4236/jilsa.2022.144007","url":null,"abstract":"","PeriodicalId":69452,"journal":{"name":"智能学习系统与应用(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70330724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Towards Immunizing Infodemic: Comprehensive Study on Assessing the Role of Artificial Intelligence and COVID-19 Pandemic 迈向免疫信息大流行:人工智能与COVID-19大流行作用评估的综合研究
Pub Date : 2022-01-01 DOI: 10.4236/jilsa.2022.143003
Maryam Roshanaei, Greggory Sywulak
{"title":"Towards Immunizing Infodemic: Comprehensive Study on Assessing the Role of Artificial Intelligence and COVID-19 Pandemic","authors":"Maryam Roshanaei, Greggory Sywulak","doi":"10.4236/jilsa.2022.143003","DOIUrl":"https://doi.org/10.4236/jilsa.2022.143003","url":null,"abstract":"","PeriodicalId":69452,"journal":{"name":"智能学习系统与应用(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70330634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synchronization of Stochastic Memristive Neural Networks with Retarded and Advanced Argument 迟滞超前参数随机记忆神经网络的同步
Pub Date : 2021-02-26 DOI: 10.4236/JILSA.2021.131001
R. Xian
In this paper, we discuss the driving-response synchronization problem for two memristive neural networks with retarded and advanced arguments under the condition of additional noise. The control law is related to the linear time-delay feedback term, and the discontinuous feedback term. Moreover, the random different equation is used to prove the stability of this theory. At the end, the simulation results verify the correctness of the theoretical results.
本文讨论了在附加噪声条件下,具有滞后参数和超前参数的两个记忆神经网络的驱动-响应同步问题。控制律与线性时滞反馈项和不连续反馈项有关。并利用随机差分方程证明了该理论的稳定性。最后,仿真结果验证了理论结果的正确性。
{"title":"Synchronization of Stochastic Memristive Neural Networks with Retarded and Advanced Argument","authors":"R. Xian","doi":"10.4236/JILSA.2021.131001","DOIUrl":"https://doi.org/10.4236/JILSA.2021.131001","url":null,"abstract":"In this paper, we discuss the driving-response synchronization problem for two memristive neural networks with retarded and advanced arguments under the condition of additional noise. The control law is related to the linear time-delay feedback term, and the discontinuous feedback term. Moreover, the random different equation is used to prove the stability of this theory. At the end, the simulation results verify the correctness of the theoretical results.","PeriodicalId":69452,"journal":{"name":"智能学习系统与应用(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47013436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Machine Learning Technology for Evaluation of Liver Fibrosis, Inflammation Activity and Steatosis (LIVERFAStTM) 评估肝纤维化、炎症活性和脂肪变性的机器学习技术(LIVERFAStTM)
Pub Date : 2020-04-09 DOI: 10.4236/jilsa.2020.122003
A. Aravind, A. G. Bahirvani, Ronald Quiambao, T. Gonzalo
Using the latest available artificial intelligence (AI) technology, an advanced algorithm LIVERFAStTM has been used to evaluate the diagnostic accuracy of machine learning (ML) biomarker algorithms to assess liver damage. Prevalence of NAFLD (Nonalcoholic fatty liver disease) and resulting NASH (nonalcoholic steatohepatitis) are constantly increasing worldwide, creating challenges for screening as the diagnosis for NASH requires invasive liver biopsy. Key issues in NAFLD patients are the differentiation of NASH from simple steatosis and identification of advanced hepatic fibrosis. In this prospective study, the staging of three different lesions of the liver to diagnose fatty liver was analyzed using a proprietary ML algorithm LIVERFAStTM developed with a database of 2862 unique medical assessments of biomarkers, where 1027 assessments were used to train the algorithm and 1835 constituted the validation set. Data of 13,068 patients who underwent the LIVERFAStTM test for evaluation of fatty liver disease were analysed. Data evaluation revealed 11% of the patients exhibited significant fibrosis with fibrosis scores 0.6 - 1.00. Approximately 7% of the population had severe hepatic inflammation. Steatosis was observed in most patients, 63%, whereas severe steatosis S3 was observed in 20%. Using modified SAF (Steatosis, Activity and Fibrosis) scores obtained using the LIVERFAStTM algorithm, NAFLD was detected in 13.41% of the patients (Sx > 0, Ay 0). Approximately 1.91% (Sx > 0, Ay = 2, Fz > 0) of the patients showed NAFLD or NASH scorings while 1.08% had confirmed NASH (Sx > 0, Ay > 2, Fz = 1 - 2) and 1.49% had advanced NASH (Sx > 0, Ay > 2, Fz = 3 - 4). The modified SAF scoring system generated by LIVERFAStTM provides a simple and convenient evaluation of NAFLD and NASH in a cohort of Southeast Asians. This system may lead to the use of noninvasive liver tests in extended populations for more accurate diagnosis of liver pathology, prediction of clinical path of individuals at all stages of liver diseases, and provision of an efficient system for therapeutic interventions.
使用最新的人工智能(AI)技术,一种先进的算法LIVERFAStTM已被用于评估机器学习(ML)生物标志物算法的诊断准确性,以评估肝损伤。NAFLD(非酒精性脂肪性肝病)和由此导致的NASH(非酒精型脂肪性肝炎)的患病率在全球范围内不断增加,这给筛查带来了挑战,因为NASH的诊断需要侵入性肝活检。NAFLD患者的关键问题是NASH与单纯脂肪变性的鉴别以及晚期肝纤维化的鉴别。在这项前瞻性研究中,使用专有的ML算法LIVERFAStTM分析了诊断脂肪肝的三种不同肝脏病变的分期,该算法由2862个独特的生物标志物医学评估数据库开发,其中1027个评估用于训练算法,1835个构成验证集。分析了13068名接受LIVERFAStTM试验评估脂肪肝的患者的数据。数据评估显示,11%的患者表现出明显的纤维化,纤维化评分为0.6-1.00。大约7%的人群患有严重的肝脏炎症。在大多数患者中观察到脂肪变性,63%,而在20%中观察到严重的S3脂肪变性。使用使用LIVERFAStTM算法获得的改良SAF(脂肪变性、活性和纤维化)评分,13.41%的患者检测到NAFLD(Sx>0,Ay0)。约1.91%(Sx>0,Ay=2,Fz>0)的患者表现为NAFLD或NASH评分,1.08%的患者已证实NASH(Sx>2,Ay>2,Fz=1-2),1.49%的患者患有晚期NASH(Sx>0,Ay>2,Fz=3-4)。LIVERFAStTM生成的改良SAF评分系统为东南亚人群中的NAFLD和NASH提供了一种简单方便的评估。该系统可以在更广泛的人群中使用非侵入性肝脏测试,以更准确地诊断肝脏病理,预测处于肝病所有阶段的个体的临床路径,并为治疗干预提供有效的系统。
{"title":"Machine Learning Technology for Evaluation of Liver Fibrosis, Inflammation Activity and Steatosis (LIVERFAStTM)","authors":"A. Aravind, A. G. Bahirvani, Ronald Quiambao, T. Gonzalo","doi":"10.4236/jilsa.2020.122003","DOIUrl":"https://doi.org/10.4236/jilsa.2020.122003","url":null,"abstract":"Using the latest available artificial intelligence (AI) technology, an advanced algorithm LIVERFAStTM has been used to evaluate the diagnostic accuracy of machine learning (ML) biomarker algorithms to assess liver damage. Prevalence of NAFLD (Nonalcoholic fatty liver disease) and resulting NASH (nonalcoholic steatohepatitis) are constantly increasing worldwide, creating challenges for screening as the diagnosis for NASH requires invasive liver biopsy. Key issues in NAFLD patients are the differentiation of NASH from simple steatosis and identification of advanced hepatic fibrosis. In this prospective study, the staging of three different lesions of the liver to diagnose fatty liver was analyzed using a proprietary ML algorithm LIVERFAStTM developed with a database of 2862 unique medical assessments of biomarkers, where 1027 assessments were used to train the algorithm and 1835 constituted the validation set. Data of 13,068 patients who underwent the LIVERFAStTM test for evaluation of fatty liver disease were analysed. Data evaluation revealed 11% of the patients exhibited significant fibrosis with fibrosis scores 0.6 - 1.00. Approximately 7% of the population had severe hepatic inflammation. Steatosis was observed in most patients, 63%, whereas severe steatosis S3 was observed in 20%. Using modified SAF (Steatosis, Activity and Fibrosis) scores obtained using the LIVERFAStTM algorithm, NAFLD was detected in 13.41% of the patients (Sx > 0, Ay 0). Approximately 1.91% (Sx > 0, Ay = 2, Fz > 0) of the patients showed NAFLD or NASH scorings while 1.08% had confirmed NASH (Sx > 0, Ay > 2, Fz = 1 - 2) and 1.49% had advanced NASH (Sx > 0, Ay > 2, Fz = 3 - 4). The modified SAF scoring system generated by LIVERFAStTM provides a simple and convenient evaluation of NAFLD and NASH in a cohort of Southeast Asians. This system may lead to the use of noninvasive liver tests in extended populations for more accurate diagnosis of liver pathology, prediction of clinical path of individuals at all stages of liver diseases, and provision of an efficient system for therapeutic interventions.","PeriodicalId":69452,"journal":{"name":"智能学习系统与应用(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43140561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Application of Dual Attention Mechanism in Chinese Image Captioning 双注意机制在中文图像字幕中的应用
Pub Date : 2020-01-15 DOI: 10.4236/jilsa.2020.121002
Yong Zhang, Jing Zhang
Objective: The Chinese description of images combines the two directions of computer vision and natural language processing. It is a typical representative of multi-mode and cross-domain problems with artificial intelligence algorithms. The image Chinese description model needs to output a Chinese description for each given test picture, describe the sentence requirements to conform to the natural language habits, and point out the important information in the image, covering the main characters, scenes, actions and other content. Since the current open source datasets are mostly in English, the research on the direction of image description is mainly in English. Chinese descriptions usually have greater flexibility in syntax and lexicalization, and the challenges of algorithm implementation are also large. Therefore, only a few people have studied image descriptions, especially Chinese descriptions. Methods: This study attempts to derive a model of image description generation from the Flickr8k-cn and Flickr30k-cn datasets. At each time period of the description, the model can decide whether to rely more on images or text information. The model captures more important information from the image to improve the richness and accuracy of the Chinese description of the image. The image description data set of this study is mainly composed of Chinese description sentences. The method consists of an encoder and a decoder. The encoder is based on a convolutional neural network. The decoder is based on a long-short memory network and is composed of a multi-modal summary generation network. Results: Experiments on Flickr8k-cn and Flickr30k-cn Chinese datasets show that the proposed method is superior to the existing Chinese abstract generation model. Conclusion: The method proposed in this paper is effective, and the performance has been greatly improved on the basis of the benchmark model. Compared with the existing Chinese abstract generation model, its performance is also superior. In the next step, more visual prior information will be incorporated into the model, such as the action category, the relationship between the object and the object, etc., to further improve the quality of the description sentence, and achieve the effect of “seeing the picture writing”.
目的:图像中文描述结合了计算机视觉和自然语言处理两个方向。它是人工智能算法中多模式、跨领域问题的典型代表。图像中文描述模型需要对每个给定的测试图片输出中文描述,描述符合自然语言习惯的句子要求,并指出图像中的重要信息,涵盖主要人物、场景、动作等内容。由于目前的开源数据集多为英文,因此对图像描述方向的研究主要以英文为主。中文描述通常在语法和词汇化方面具有较大的灵活性,但算法实现的挑战也很大。因此,对图像描述,尤其是中文描述进行研究的人很少。方法:本研究试图从Flickr8k-cn和Flickr30k-cn数据集中导出图像描述生成模型。在描述的每个时间段,模型可以决定更多地依赖图像还是文本信息。该模型从图像中捕获更多重要信息,提高了图像中文描述的丰富性和准确性。本研究的图像描述数据集主要由中文描述句组成。该方法包括一个编码器和一个解码器。编码器基于卷积神经网络。该解码器基于长-短记忆网络,由多模态摘要生成网络组成。结果:在Flickr8k-cn和Flickr30k-cn中文数据集上的实验表明,本文提出的方法优于现有的中文摘要生成模型。结论:本文提出的方法是有效的,在基准模型的基础上,性能有了很大的提高。与现有中文抽象生成模型相比,该模型的性能也较为优越。下一步将在模型中加入更多的视觉先验信息,如动作类别、对象与对象之间的关系等,进一步提高描述句子的质量,达到“见图写字”的效果。
{"title":"Application of Dual Attention Mechanism in Chinese Image Captioning","authors":"Yong Zhang, Jing Zhang","doi":"10.4236/jilsa.2020.121002","DOIUrl":"https://doi.org/10.4236/jilsa.2020.121002","url":null,"abstract":"Objective: The Chinese description of images combines the two directions of computer vision and natural language processing. It is a typical representative of multi-mode and cross-domain problems with artificial intelligence algorithms. The image Chinese description model needs to output a Chinese description for each given test picture, describe the sentence requirements to conform to the natural language habits, and point out the important information in the image, covering the main characters, scenes, actions and other content. Since the current open source datasets are mostly in English, the research on the direction of image description is mainly in English. Chinese descriptions usually have greater flexibility in syntax and lexicalization, and the challenges of algorithm implementation are also large. Therefore, only a few people have studied image descriptions, especially Chinese descriptions. Methods: This study attempts to derive a model of image description generation from the Flickr8k-cn and Flickr30k-cn datasets. At each time period of the description, the model can decide whether to rely more on images or text information. The model captures more important information from the image to improve the richness and accuracy of the Chinese description of the image. The image description data set of this study is mainly composed of Chinese description sentences. The method consists of an encoder and a decoder. The encoder is based on a convolutional neural network. The decoder is based on a long-short memory network and is composed of a multi-modal summary generation network. Results: Experiments on Flickr8k-cn and Flickr30k-cn Chinese datasets show that the proposed method is superior to the existing Chinese abstract generation model. Conclusion: The method proposed in this paper is effective, and the performance has been greatly improved on the basis of the benchmark model. Compared with the existing Chinese abstract generation model, its performance is also superior. In the next step, more visual prior information will be incorporated into the model, such as the action category, the relationship between the object and the object, etc., to further improve the quality of the description sentence, and achieve the effect of “seeing the picture writing”.","PeriodicalId":69452,"journal":{"name":"智能学习系统与应用(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41874573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Combining Artificial Immune System and Clustering Analysis: A Stock Market Anomaly Detection Model 结合人工免疫系统和聚类分析的股票市场异常检测模型
Pub Date : 2020-01-01 DOI: 10.4236/jilsa.2020.124005
Liam Close, R. Kashef
Artificial intelligence research in the stock market sector has been heavily geared towards stock price prediction rather than stock price manipulation. As online trading systems have increased the amount of high volume and re-al-time data transactions, the stock market has increased vulnerability to at-tacks. This paper aims to detect these attacks based on normal trade behavior using an Artificial Immune System (AIS) approach combined with one of four clustering algorithms. The AIS approach is inspired by its proven ability to handle time-series data and its ability to detect abnormal behavior while only being trained on regular trade behavior. These two main points are essential as the models need to adapt over time to adjust to normal trade behavior as it evolves, and due to confidentiality and data restrictions, real-world manipula-tions are not available for training. This paper discovers a competitive alterna-tive to the leading approach and investigates the effects of combining AIS with clustering algorithms; Kernel Density Estimation, Self-Organized Maps, Densi-ty-Based Spatial Clustering of Applications with Noise and Spectral clustering. The best performing solution achieves leading performance using common clustering metrics, including Area Under the Curve, False Alarm Rate, False Negative Rate, and Computation Time.
股票市场领域的人工智能研究主要面向股价预测,而不是股价操纵。随着在线交易系统增加了高容量和实时数据交易的数量,股票市场越来越容易受到攻击。本文旨在使用人工免疫系统(AIS)方法结合四种聚类算法中的一种来检测基于正常交易行为的这些攻击。AIS方法的灵感来自于其经过验证的处理时间序列数据的能力和检测异常行为的能力,而只需接受常规交易行为的培训。这两个要点是至关重要的,因为模型需要随着时间的推移适应正常的贸易行为,并且由于机密性和数据限制,现实世界的操作无法用于培训。本文发现了一种有竞争力的替代方法,并研究了将AIS与聚类算法相结合的效果;核密度估计,自组织地图,基于密度的空间聚类与噪声和谱聚类的应用。使用常用的聚类指标(包括曲线下面积、虚警率、误报率和计算时间),性能最好的解决方案可以实现领先的性能。
{"title":"Combining Artificial Immune System and Clustering Analysis: A Stock Market Anomaly Detection Model","authors":"Liam Close, R. Kashef","doi":"10.4236/jilsa.2020.124005","DOIUrl":"https://doi.org/10.4236/jilsa.2020.124005","url":null,"abstract":"Artificial intelligence research in the stock market sector has been heavily geared towards stock price prediction rather than stock price manipulation. As online trading systems have increased the amount of high volume and re-al-time data transactions, the stock market has increased vulnerability to at-tacks. This paper aims to detect these attacks based on normal trade behavior using an Artificial Immune System (AIS) approach combined with one of four clustering algorithms. The AIS approach is inspired by its proven ability to handle time-series data and its ability to detect abnormal behavior while only being trained on regular trade behavior. These two main points are essential as the models need to adapt over time to adjust to normal trade behavior as it evolves, and due to confidentiality and data restrictions, real-world manipula-tions are not available for training. This paper discovers a competitive alterna-tive to the leading approach and investigates the effects of combining AIS with clustering algorithms; Kernel Density Estimation, Self-Organized Maps, Densi-ty-Based Spatial Clustering of Applications with Noise and Spectral clustering. The best performing solution achieves leading performance using common clustering metrics, including Area Under the Curve, False Alarm Rate, False Negative Rate, and Computation Time.","PeriodicalId":69452,"journal":{"name":"智能学习系统与应用(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70330570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 19
Transcription Factor Bound Regions Prediction: Word2Vec Technique with Convolutional Neural Network 转录因子结合区预测:基于卷积神经网络的Word2Vec技术
Pub Date : 2020-01-01 DOI: 10.4236/jilsa.2020.121001
Rixin Chen, Ruoxi Dai, Mingye Wang
Genome-wide epigenomic datasets allow us to validate the biological function of motifs and understand the regulatory mechanisms more comprehensively. How different motifs determine whether transcription factors (TFs) can bind to DNA at a specific position is a critical research question. In this project, we apply computational techniques that were used in Natural Language Processing (NLP) to predict the Transcription Factor Bound Regions (TFBRs) given motif instances. Most existing motif prediction methods using deep neural network apply base sequences with one-hot encoding as an input feature to realize TFBRs identification, contributing to low-resolution and indirect binding mechanisms. However, how the collective effect of motifs on binding sites is complicated to figure out. In our pipeline, we apply Word2Vec algorithm, with names of motifs as an input to predict TFBRs utilizing Convolutional Neural Network (CNN) to realize binary classification, based on the ENCODE dataset. In this regard, we consider different types of motifs as separate “words”, and their corresponding TFBR as the meanings of “sentences”. One “sentence” itself is merely the combination of these motifs, and all “sentences” compose of the whole “passage”. For each binding site, we do the binary classification within different cell types to show the performance of our model in different binding sites and cell types. Each “word” has a corresponding vector in high dimensions, and the distances between each vector can be figured out, so we can extract the similarity between each motif, and the explicit binding mechanism from our model. We apply Convolutional Neural Network (CNN) to extract features in the process of mapping and pooling from motif vectors extracted by Word2Vec Algorithm and gain the result of 87% accuracy at the peak.
全基因组表观基因组数据集使我们能够验证基序的生物学功能,并更全面地了解其调控机制。不同的基序如何决定转录因子(tf)能否在特定位置与DNA结合是一个关键的研究问题。在这个项目中,我们应用了在自然语言处理(NLP)中使用的计算技术来预测给定基序实例的转录因子结合区(TFBRs)。现有的基于深度神经网络的基序预测方法大多采用单热编码的碱基序列作为输入特征来实现tfbr的识别,存在低分辨率和间接结合机制。然而,结合位点上的基序是如何集体作用的,尚不清楚。在我们的管道中,我们基于ENCODE数据集,采用Word2Vec算法,以motif的名称作为输入,利用卷积神经网络(CNN)实现二值分类来预测tfbr。在这方面,我们将不同类型的基元视为单独的“词”,将其对应的TFBR视为“句”的意义。一个“句子”本身就是这些母题的组合,所有的“句子”都是由整个“段落”组成的。对于每个结合位点,我们在不同的细胞类型中进行二元分类,以显示我们的模型在不同结合位点和细胞类型中的性能。每个“词”在高维上都有一个对应的向量,并且每个向量之间的距离可以计算出来,因此我们可以从我们的模型中提取每个motif之间的相似度,以及明确的绑定机制。利用卷积神经网络(CNN)对Word2Vec算法提取的motif向量进行映射和池化过程中的特征提取,峰值准确率达到87%。
{"title":"Transcription Factor Bound Regions Prediction: Word2Vec Technique with Convolutional Neural Network","authors":"Rixin Chen, Ruoxi Dai, Mingye Wang","doi":"10.4236/jilsa.2020.121001","DOIUrl":"https://doi.org/10.4236/jilsa.2020.121001","url":null,"abstract":"Genome-wide epigenomic datasets allow us to validate the biological function of motifs and understand the regulatory mechanisms more comprehensively. How different motifs determine whether transcription factors (TFs) can bind to DNA at a specific position is a critical research question. In this project, we apply computational techniques that were used in Natural Language Processing (NLP) to predict the Transcription Factor Bound Regions (TFBRs) given motif instances. Most existing motif prediction methods using deep neural network apply base sequences with one-hot encoding as an input feature to realize TFBRs identification, contributing to low-resolution and indirect binding mechanisms. However, how the collective effect of motifs on binding sites is complicated to figure out. In our pipeline, we apply Word2Vec algorithm, with names of motifs as an input to predict TFBRs utilizing Convolutional Neural Network (CNN) to realize binary classification, based on the ENCODE dataset. In this regard, we consider different types of motifs as separate “words”, and their corresponding TFBR as the meanings of “sentences”. One “sentence” itself is merely the combination of these motifs, and all “sentences” compose of the whole “passage”. For each binding site, we do the binary classification within different cell types to show the performance of our model in different binding sites and cell types. Each “word” has a corresponding vector in high dimensions, and the distances between each vector can be figured out, so we can extract the similarity between each motif, and the explicit binding mechanism from our model. We apply Convolutional Neural Network (CNN) to extract features in the process of mapping and pooling from motif vectors extracted by Word2Vec Algorithm and gain the result of 87% accuracy at the peak.","PeriodicalId":69452,"journal":{"name":"智能学习系统与应用(英文)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70330924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
期刊
智能学习系统与应用(英文)
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1