Pub Date : 2020-01-01DOI: 10.23893/1307-2080.aps.05827
N. Taner, M. E. Tatlıpınar, A. Aydın, G. Omurtag
{"title":"Investigation of the diabetic patients\" knowledge on diabetes and the role of clinical pharmacist in providing pharmaceutical care to them","authors":"N. Taner, M. E. Tatlıpınar, A. Aydın, G. Omurtag","doi":"10.23893/1307-2080.aps.05827","DOIUrl":"https://doi.org/10.23893/1307-2080.aps.05827","url":null,"abstract":"","PeriodicalId":6962,"journal":{"name":"ACTA Pharmaceutica Sciencia","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68931742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.23893/1307-2080.aps.05823
M. Ezzat, B. A. Razik
{"title":"Molecular drug design and docking study of novel n- substituted celecoxib derivatives as selective cyclooxygenase-2 inhibitors","authors":"M. Ezzat, B. A. Razik","doi":"10.23893/1307-2080.aps.05823","DOIUrl":"https://doi.org/10.23893/1307-2080.aps.05823","url":null,"abstract":"","PeriodicalId":6962,"journal":{"name":"ACTA Pharmaceutica Sciencia","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68931581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.23893/1307-2080.aps.05706
Derya Duran, S. Ötleş, E. Karasulu
Silybum marianum (L.) Gaertn (synonym Carduus marianus L.) is known as milk thistle. It belongs to Asteraceae family. It originates from the Mediterranean area. However, it has spread to other countries in Europe, Asia, Australia and both Americas1. The primary content of S. marianum is the presence of a group of flavonolignans known as silymarin in the pericarp and seed coat 2. The rate of flavonolignans is usually between 1.5% and 3.5% of the fruit weight1. Silymarin consists of silybin, isosilybin, silydianin, silychristin, isosilychrystin and isosilybinin1.3. Since among flavonolignan compounds silybin has detoxificationing ABSTRACT
{"title":"Determination amount of silymarin and pharmaceutical products from milk thistle waste obtained from cold press","authors":"Derya Duran, S. Ötleş, E. Karasulu","doi":"10.23893/1307-2080.aps.05706","DOIUrl":"https://doi.org/10.23893/1307-2080.aps.05706","url":null,"abstract":"Silybum marianum (L.) Gaertn (synonym Carduus marianus L.) is known as milk thistle. It belongs to Asteraceae family. It originates from the Mediterranean area. However, it has spread to other countries in Europe, Asia, Australia and both Americas1. The primary content of S. marianum is the presence of a group of flavonolignans known as silymarin in the pericarp and seed coat 2. The rate of flavonolignans is usually between 1.5% and 3.5% of the fruit weight1. Silymarin consists of silybin, isosilybin, silydianin, silychristin, isosilychrystin and isosilybinin1.3. Since among flavonolignan compounds silybin has detoxificationing ABSTRACT","PeriodicalId":6962,"journal":{"name":"ACTA Pharmaceutica Sciencia","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68930188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.23893/1307-2080.aps.05725
O. Aremu, John Paul Adjuzie, O. Olayemi, J. E. Okoh, K. Ekere, O. Fatokun, M. Emeje
A study has been made on the formulation and evaluation of Acetylsalicylic acid (ASA) suppositories using Goat fat (GF) and its binary blends with Palm Kernel oil and Liquid Paraffin. Cocoa butter was used as the standard reference suppository base. Rectal suppositories containing ASA (300 mg) in pre-calibrated mould were prepared by fusion method and evaluated for appearance, crushing strength, weight variation, melting point, liquefaction time, content uniformity and in-vitro release using standard procedures. Liquefaction or disintegration time (minutes) followed this order: ACB(4.40±0.84) AGF >AGL>ACB (p<0.05). Results obtained indicated that the bases used generally could be ranked in the order of GL > GP > GF > CB (p<0.05) in terms of favourable physicochemical properties investigated. The foregoing indicates that GL or GP has promising potential and could be a substitute suppository base in the formulation of ASA suppositories.
研究了山羊脂(GF)及其与棕榈仁油和液体石蜡二元共混物的乙酰水杨酸(ASA)栓剂的配方及性能评价。以可可脂为标准参考栓底。采用熔融法制备含ASA (300 mg)的直肠栓剂，采用标准程序对其外观、抗压强度、重量变化、熔点、液化时间、含量均匀性和体外释放度进行评价。液化或解体时间(分钟)顺序为:ACB(4.40±0.84)AGF >AGL>ACB (p GP > GF > CB(p<0.05)。上述结果表明，GL或GP具有良好的潜力，可作为ASA栓剂制剂中的替代栓剂碱。
{"title":"Formulation and evaluation of acetylsalicylic acid suppositories using capra hircus (goat) fat and its binary blends","authors":"O. Aremu, John Paul Adjuzie, O. Olayemi, J. E. Okoh, K. Ekere, O. Fatokun, M. Emeje","doi":"10.23893/1307-2080.aps.05725","DOIUrl":"https://doi.org/10.23893/1307-2080.aps.05725","url":null,"abstract":"A study has been made on the formulation and evaluation of Acetylsalicylic acid (ASA) suppositories using Goat fat (GF) and its binary blends with Palm Kernel oil and Liquid Paraffin. Cocoa butter was used as the standard reference suppository base. Rectal suppositories containing ASA (300 mg) in pre-calibrated mould were prepared by fusion method and evaluated for appearance, crushing strength, weight variation, melting point, liquefaction time, content uniformity and in-vitro release using standard procedures. Liquefaction or disintegration time (minutes) followed this order: ACB(4.40±0.84) <AGL(6.20±0.83) <AGP(7.14±0.84) < AGF(11.45±2.20) while cumulative drug release (%) is AGP> AGF >AGL>ACB (p<0.05). Results obtained indicated that the bases used generally could be ranked in the order of GL > GP > GF > CB (p<0.05) in terms of favourable physicochemical properties investigated. The foregoing indicates that GL or GP has promising potential and could be a substitute suppository base in the formulation of ASA suppositories.","PeriodicalId":6962,"journal":{"name":"ACTA Pharmaceutica Sciencia","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68930977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.23893/1307-2080.aps.05716
M. Bhatia, Sunidhi Lohan
Flax (Linum usitatissimum), also known as common flax or linseed consists of the dried fully ripe seeds of the genus Linum belonging to family Linaceae 1. Chemically, it contains d-galacturonic acid, l-rhamnose, l-galactose, and dxylose. It is gluten free and also rich in omega-3, omega-6, α-linolenic acid, lignans, high quality proteins and fibers. The flax seed mucilage has been widely ABSTRACT
{"title":"Flax seed mucilage-chitosan polyelectrolyte complex nanoparticles: optimization, characterization and evaluation","authors":"M. Bhatia, Sunidhi Lohan","doi":"10.23893/1307-2080.aps.05716","DOIUrl":"https://doi.org/10.23893/1307-2080.aps.05716","url":null,"abstract":"Flax (Linum usitatissimum), also known as common flax or linseed consists of the dried fully ripe seeds of the genus Linum belonging to family Linaceae 1. Chemically, it contains d-galacturonic acid, l-rhamnose, l-galactose, and dxylose. It is gluten free and also rich in omega-3, omega-6, α-linolenic acid, lignans, high quality proteins and fibers. The flax seed mucilage has been widely ABSTRACT","PeriodicalId":6962,"journal":{"name":"ACTA Pharmaceutica Sciencia","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68931396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.23893/1307-2080.aps.05701
U. Güven, M. Berkman, Y. Yazan
The conventional eye drops are the most convenient and patient compliant non-invasive route for topical ophthalmic drug delivery. Nasolachrymal drainage, epithelial membrane barriers and non-productive absorption of these ophthalmic preparations can result in poor ocular bioavailability and systemic absorption leading side effects. The limited duration time requires frequently dosing up to 4 times per day for many treatments 1. The active ingredient can ABSTRACT
{"title":"Development and validation of uplc method for the determination of olopatadine hydrochloride in polymeric nanoparticles","authors":"U. Güven, M. Berkman, Y. Yazan","doi":"10.23893/1307-2080.aps.05701","DOIUrl":"https://doi.org/10.23893/1307-2080.aps.05701","url":null,"abstract":"The conventional eye drops are the most convenient and patient compliant non-invasive route for topical ophthalmic drug delivery. Nasolachrymal drainage, epithelial membrane barriers and non-productive absorption of these ophthalmic preparations can result in poor ocular bioavailability and systemic absorption leading side effects. The limited duration time requires frequently dosing up to 4 times per day for many treatments 1. The active ingredient can ABSTRACT","PeriodicalId":6962,"journal":{"name":"ACTA Pharmaceutica Sciencia","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68930019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.23893/1307-2080.APS.05721
O. Adegoke, O. E. Thomas, Deborah Babatunde, O. Oyelami, A. Adediran, Abayomi E. Omotosho
To develop two new spectrophotometric methods for the analysis of isoniazid in bulk form and tablets. The methods involved condensation of isoniazid with salicylaldehyde and diazo coupling with diazotized p-nitroaniline. Critical factors were optimised; evidence for new product formation, selection of analytical wavelengths, temperature and time and solvent for dilution. Validation was carried out according to ICH guidelines. The new methods were used for isoniazid tablets. Isoniazid formed an imine and azo adduct readily with the two reagents at 30 0C after 5 and 20 mins, and determined at 405 and 420 nm, respectively. Low LODs were obtained for the two methods and recoveries were generally above 98%. The methods were successfully adopted for the assay of isoniazid in tablets and there were no significant differences in the contents when compared with the official titrimetric method of analysis. The methods could find application as in-process method in pharmaceutical industries.
{"title":"Two new spectrophotometric methods for the determination of isoniazid in bulk form and tablet dosage form","authors":"O. Adegoke, O. E. Thomas, Deborah Babatunde, O. Oyelami, A. Adediran, Abayomi E. Omotosho","doi":"10.23893/1307-2080.APS.05721","DOIUrl":"https://doi.org/10.23893/1307-2080.APS.05721","url":null,"abstract":"To develop two new spectrophotometric methods for the analysis of isoniazid in bulk form and tablets. The methods involved condensation of isoniazid with salicylaldehyde and diazo coupling with diazotized p-nitroaniline. Critical factors were optimised; evidence for new product formation, selection of analytical wavelengths, temperature and time and solvent for dilution. Validation was carried out according to ICH guidelines. The new methods were used for isoniazid tablets. Isoniazid formed an imine and azo adduct readily with the two reagents at 30 0C after 5 and 20 mins, and determined at 405 and 420 nm, respectively. Low LODs were obtained for the two methods and recoveries were generally above 98%. The methods were successfully adopted for the assay of isoniazid in tablets and there were no significant differences in the contents when compared with the official titrimetric method of analysis. The methods could find application as in-process method in pharmaceutical industries.","PeriodicalId":6962,"journal":{"name":"ACTA Pharmaceutica Sciencia","volume":"53 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68931025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.23893/1307-2080.aps.05726
Peter A Segun, Morenike Gbadebo, Modupe Adebowale, Katherine Olufolabo, A. Fred-jaiyesimi
Macaranga hurifolia Beille (Euphorbiaceae) is used in Nigerian ethnobotany for treating several diseases. This work was designed to determine the phytochemical composition, as well as, investigate the anti-inflammatory and hypoglycaemic activities of Macaranga hurifolia extract (MHE). MHE was evaluated for its anti-inflammatory and antidiabetic potentials using the egg albumin inflammatory model and alloxan-induced diabetic rat model, respectively. MHE produced both dose-dependent and time-dependent inhibition of oedema development with its maximum effect (69.6%) produced at the dose of 300 mg/kg. The acute in vivo antidiabetic study revealed that MHE produced significant hypoglycaemic effects at doses of 200 mg/kg (54% reduction) and 400 mg/kg (59% reduction), comparable to glibenclamide (5 mg/kg) which caused a 42% decrease, while all the treatment groups produced at least 25% reduction in blood glucose level for the chronic study. This study established, for the first time, the anti-inflammatory and antidiabetic potentials of Macaranga hurifolia.
{"title":"Investigation of the anti-inflammatory and hypoglycaemic effects of macaranga hurifolia beille (eurphorbiaceae) extract on wistar albino rats","authors":"Peter A Segun, Morenike Gbadebo, Modupe Adebowale, Katherine Olufolabo, A. Fred-jaiyesimi","doi":"10.23893/1307-2080.aps.05726","DOIUrl":"https://doi.org/10.23893/1307-2080.aps.05726","url":null,"abstract":"Macaranga hurifolia Beille (Euphorbiaceae) is used in Nigerian ethnobotany for treating several diseases. This work was designed to determine the phytochemical composition, as well as, investigate the anti-inflammatory and hypoglycaemic activities of Macaranga hurifolia extract (MHE). MHE was evaluated for its anti-inflammatory and antidiabetic potentials using the egg albumin inflammatory model and alloxan-induced diabetic rat model, respectively. MHE produced both dose-dependent and time-dependent inhibition of oedema development with its maximum effect (69.6%) produced at the dose of 300 mg/kg. The acute in vivo antidiabetic study revealed that MHE produced significant hypoglycaemic effects at doses of 200 mg/kg (54% reduction) and 400 mg/kg (59% reduction), comparable to glibenclamide (5 mg/kg) which caused a 42% decrease, while all the treatment groups produced at least 25% reduction in blood glucose level for the chronic study. This study established, for the first time, the anti-inflammatory and antidiabetic potentials of Macaranga hurifolia.","PeriodicalId":6962,"journal":{"name":"ACTA Pharmaceutica Sciencia","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68931032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.23893/1307-2080.aps.05727
A. Ayyash, H. Q. A. Habeeb
A series of novel 2-azetidinons entitled N, N’-bis[3-chloro-2-oxo-4-(substituted pyridine-2-yl)-azetidin-1-yl] pyrazine-2,3-dicarboxamide and N,N’-bis[3,3-dichloro-2-oxo-4-(substitutedpyridine-2-yl)-azetidin-1-yl] pyrazine-2,3-dicarboxamide have been synthesized from the relating newly Schiff bases by [2+2] cycloaddition reaction in good yields. Starting with pyrazine-2,3-dicarboxylic acid which was converted to the corresponding diester in absolute ethanol and glacial acetic acid as a catalyst. After that, the hydazinolysis of resulted diester with hydrazine hydrate afforded dicarbohydrazide which further treated with different substituted pyridine-2-carbaldehyde to give new Schiff bases. These new Schiff bases were reacted with chloroacetochloride and (or) dichloroacetochloride in presence of trimethylamine in DMF solvent under reflux and stirring to yield new derivatives of titled compounds. The structural assignments were estimated from their spectroscopic analysis such as IR,1H NMR, 13C NMR, and C, H, N elemental analysis. The newly prepared 2-azetidinones have been screened for their antimicrobial activity and some of them revealed excellent antibacterial and antifungal activities.
{"title":"A novel bioactive compounds of 2-azetidinone derived from pyrazin dicarboxylic acid: synthesis and antmicrobial screening","authors":"A. Ayyash, H. Q. A. Habeeb","doi":"10.23893/1307-2080.aps.05727","DOIUrl":"https://doi.org/10.23893/1307-2080.aps.05727","url":null,"abstract":"A series of novel 2-azetidinons entitled N, N’-bis[3-chloro-2-oxo-4-(substituted pyridine-2-yl)-azetidin-1-yl] pyrazine-2,3-dicarboxamide and N,N’-bis[3,3-dichloro-2-oxo-4-(substitutedpyridine-2-yl)-azetidin-1-yl] pyrazine-2,3-dicarboxamide have been synthesized from the relating newly Schiff bases by [2+2] cycloaddition reaction in good yields. Starting with pyrazine-2,3-dicarboxylic acid which was converted to the corresponding diester in absolute ethanol and glacial acetic acid as a catalyst. After that, the hydazinolysis of resulted diester with hydrazine hydrate afforded dicarbohydrazide which further treated with different substituted pyridine-2-carbaldehyde to give new Schiff bases. These new Schiff bases were reacted with chloroacetochloride and (or) dichloroacetochloride in presence of trimethylamine in DMF solvent under reflux and stirring to yield new derivatives of titled compounds. The structural assignments were estimated from their spectroscopic analysis such as IR,1H NMR, 13C NMR, and C, H, N elemental analysis. The newly prepared 2-azetidinones have been screened for their antimicrobial activity and some of them revealed excellent antibacterial and antifungal activities.","PeriodicalId":6962,"journal":{"name":"ACTA Pharmaceutica Sciencia","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68931111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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