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Long COVID, neuropsychiatric disorders, psychotropics, present and future. 长COVID,神经精神疾病,精神药物,现在和未来。
IF 3.8 4区 医学 Q1 Medicine Pub Date : 2022-06-01 Epub Date: 2022-03-03 DOI: 10.1017/neu.2022.6
Siu Wa Tang, Brian E Leonard, Daiga Maret Helmeste

Long COVID refers to the lingering symptoms which persist or appear after the acute illness. The dominant long COVID symptoms in the two years since the pandemic began (2020-2021) have been depression, anxiety, fatigue, concentration and cognitive impairments with few reports of psychosis. Whether other symptoms will appear later on is not yet known. For example, dopamine-dependent movement disorders generally take many years before first symptoms are seen. Post-stroke depression and anxiety may explain many of the early long COVID cases. Hemorrhagic, hypoxic and inflammatory damages of the central nervous system, unresolved systematic inflammation, metabolic impairment, cerebral vascular accidents such as stroke, hypoxia from pulmonary damages and fibrotic changes are among the major causes of long COVID. Glucose metabolic and hypoxic brain issues likely predispose subjects with pre-existing diabetes, cardiovascular or lung problems to long COVID as well. Preliminary data suggest that psychotropic medications may not be a danger but could instead be beneficial in combating COVID-19 infection. The same is true for diabetes medications such as metformin. Thus, a focus on sigma-1 receptor ligands and glucose metabolism is expected to be useful for new drug development as well as the repurposing of current drugs. The reported protective effects of psychotropics and antihistamines against COVID-19, the earlier reports of reduced number of sigma-1 receptors in post-mortem schizophrenic brains, with many antidepressant and antipsychotic drugs being antihistamines with significant affinity for the sigma-1 receptor, support the role of sigma and histamine receptors in neuroinflammation and viral infections. Literature and data in all these areas are accumulating at a fast rate. We reviewed and discussed the relevant and important literature.

“长冠”是指急性发病后持续或出现的症状。自大流行开始(2020-2021年)以来的两年里,主要的长期COVID症状是抑郁、焦虑、疲劳、注意力不集中和认知障碍,很少有精神病的报告。以后是否会出现其他症状尚不清楚。例如,多巴胺依赖型运动障碍通常需要很多年才会出现最初的症状。中风后的抑郁和焦虑可以解释许多早期的长冠状病毒病例。中枢神经系统的出血性、缺氧和炎症损伤、未解决的系统性炎症、代谢障碍、脑血管意外(如中风)、肺损伤引起的缺氧和纤维化改变是长COVID的主要原因。葡萄糖代谢和大脑缺氧问题也可能使患有糖尿病、心血管或肺部疾病的受试者更易患COVID。初步数据表明,精神药物可能没有危险,反而可能有助于对抗COVID-19感染。二甲双胍等治疗糖尿病的药物也是如此。因此,对sigma-1受体配体和葡萄糖代谢的关注有望对新药开发以及现有药物的再利用有所帮助。精神药物和抗组胺药对COVID-19的保护作用的报道,早期关于死后精神分裂症患者大脑中sigma-1受体数量减少的报道,以及许多抗抑郁和抗精神病药物是与sigma-1受体有显著亲和力的抗组胺药,支持sigma和组胺受体在神经炎症和病毒感染中的作用。所有这些领域的文献和数据都在快速积累。我们回顾并讨论了相关的重要文献。
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引用次数: 27
Monitoring of COVID-19 pandemic-related psychopathology using machine learning. 利用机器学习监测COVID-19大流行相关精神病理。
IF 3.8 4区 医学 Q1 Medicine Pub Date : 2022-06-01 Epub Date: 2022-01-19 DOI: 10.1017/neu.2022.2
Kenneth C Enevoldsen, Andreas A Danielsen, Christopher Rohde, Oskar H Jefsen, Kristoffer L Nielbo, Søren D Østergaard

The COVID-19 pandemic is believed to have a major negative impact on global mental health due to the viral disease itself as well as the associated lockdowns, social distancing, isolation, fear, and increased uncertainty. Individuals with preexisting mental illness are likely to be particularly vulnerable to these conditions and may develop outright 'COVID-19-related psychopathology'. Here, we trained a machine learning model on structured and natural text data from electronic health records to identify COVID-19 pandemic-related psychopathology among patients receiving care in the Psychiatric Services of the Central Denmark Region. Subsequently, applying this model, we found that pandemic-related psychopathology covaries with the pandemic pressure over time. These findings may aid psychiatric services in their planning during the ongoing and future pandemics. Furthermore, the results are a testament to the potential of applying machine learning to data from electronic health records.

据信,由于病毒性疾病本身以及相关的封锁、社交距离、隔离、恐惧和不确定性增加,COVID-19大流行对全球心理健康产生了重大负面影响。先前存在精神疾病的人可能特别容易受到这些疾病的影响,并可能直接发展为“与covid -19相关的精神病理学”。在这里,我们在电子健康记录的结构化和自然文本数据上训练了一个机器学习模型,以识别在丹麦中部地区精神科服务中心接受治疗的患者中与COVID-19大流行相关的精神病理学。随后,应用该模型,我们发现,随着时间的推移,与大流行相关的精神病理学随大流行压力而变化。这些发现可能有助于精神科服务在当前和未来流行病期间的规划。此外,研究结果证明了将机器学习应用于电子健康记录数据的潜力。
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引用次数: 0
Circuits Regulating Pleasure and Happiness - Focus on Potential Biomarkers for Circuitry including the Habenuloid Complex. 调节快乐和幸福的电路——关注电路的潜在生物标志物,包括Habenuloid复合体。
IF 3.8 4区 医学 Q1 Medicine Pub Date : 2022-05-19 DOI: 10.1017/neu.2022.15
A. Loonen, S. Ivanova
INTRODUCTIONThe multiplicity and complexity of the neuronal connections in the central nervous system make it difficult to disentangle circuits that play an essential role in the development or treatment of (neuro)psychiatric disorders. By choosing the evolutionary development of the forebrain as a starting point, a certain order in the connections can be created. The dorsal diencephalic connection (DDC) system can be applied for the development of biomarkers that can predict treatment response.MATERIALS AND METHODSAfter providing a brief introduction to the theory, we examined neuroanatomical publications on the connectivity of the DDC system. We then searched for neurochemical components that are specific for the habenula.RESULTS AND DISCUSSIONThe best strategy to find biomarkers which reflect the function of the habenular connection is to use genetic variants of receptors, transporters or enzymes specific to this complex. By activating these with probes and measuring the response in people with different functional genotypes, the usefulness of biomarkers can be assessed.CONCLUSIONThe most promising biomarkers in this respect are those linked to activation or inhibition of the nicotine receptor, dopamine D4 receptor, μ-opioid receptor and also those of the functioning of habenular glia cells (astrocytes and microglia).
引言中枢神经系统中神经元连接的多样性和复杂性使得很难解开在(神经)精神疾病的发展或治疗中发挥重要作用的回路。通过选择前脑的进化发展作为起点,可以在连接中创建一定的顺序。间脑背侧连接(DDC)系统可用于开发可预测治疗反应的生物标志物。材料和方法在简要介绍该理论后,我们检查了关于DDC系统连接的神经解剖学出版物。然后,我们寻找对缰核有特异性的神经化学成分。结果和讨论寻找反映缰核连接功能的生物标志物的最佳策略是使用该复合物特异的受体、转运蛋白或酶的遗传变体。通过用探针激活这些,并测量具有不同功能基因型的人的反应,可以评估生物标志物的有用性。结论在这方面最有前景的生物标志物是那些与尼古丁受体、多巴胺D4受体、μ-阿片受体的激活或抑制有关的生物标志,以及那些与缰核神经胶质细胞(星形胶质细胞和小胶质细胞)的功能有关的生物标记。
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引用次数: 8
Neuropsychiatric symptoms in post COVID-19 long haulers. COVID-19后长途跋涉者的神经精神症状
IF 3.8 4区 医学 Q1 Medicine Pub Date : 2022-05-11 DOI: 10.1017/neu.2022.13
Hussam Y. Alghamdi, Abdulaziz M. Alrashed, Amjad M. Jawhari, A. S. Abdel-Moneim
BACKGROUNDLong haulers have been recently reported after contracting coronavirus disease (COVID-19). In the present study, we aimed to screen for the neuropsychiatric signs detected <1 to >6 months after infection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and to determine whether vaccination has an effect on them.METHODSAn online survey was conducted among participants who had been diagnosed with laboratory-confirmed SARS-CoV-2 infection. The clinical signs and durations of neuropsychiatric complaints and their correlations to sex, age, severity of COVID-19 signs, and vaccination status were screened.RESULTSA total of 2218 individuals, including 1358 females and 860 males, with an age range of 12-70 years, submitted their responses. The respondents experienced cognitive dysfunction, mood alteration, depression, tinnitus, sleep disorders, and loss of taste and smell, with prevalence rates ranging from 18.9% (tinnitus) to 63.9% (loss of taste and smell). Of the respondents, 2.2-7.7% of confirmed the persistence of symptoms for >6 months. Tinnitus was the least common complaint, and only 2.2% of the study participants had tinnitus for >6 months. Meanwhile, mood alteration persisted for >6 months in 7.6% of the study participants. More respondents who received two doses of BNT162b2 vaccine showed persistent symptoms than those in the other groups. Disease severity and female sex were identified as potential determinants of the development and persistency of such symptoms.CONCLUSIONPost-COVID neuropsychiatric symptoms were present in considerable percentages of the study participants with SARS-CoV-2 infection, persisting for >6 months in up to 7.6% of the participants.
背景最近有报道称长途搬运工感染了冠状病毒病(COVID-19)。在本研究中,我们旨在筛查感染严重急性呼吸综合征冠状病毒2 (SARS-CoV-2) 6个月后检测到的神经精神体征,并确定疫苗接种是否对其有影响。方法对实验室确诊的SARS-CoV-2感染患者进行在线调查。筛选神经精神疾病的临床症状和持续时间及其与性别、年龄、COVID-19症状严重程度和疫苗接种状况的相关性。结果共有2218人提交问卷,其中女性1358人,男性860人,年龄12 ~ 70岁。受访者经历认知功能障碍、情绪改变、抑郁、耳鸣、睡眠障碍、味觉和嗅觉丧失,患病率从18.9%(耳鸣)到63.9%(味觉和嗅觉丧失)不等。在应答者中,2.2-7.7%的人确认症状持续6个月。耳鸣是最不常见的抱怨,只有2.2%的研究参与者有耳鸣长达60个月。与此同时,7.6%的研究参与者的情绪变化持续了60个月。接受两剂BNT162b2疫苗的应答者比其他组出现持续症状的应答者更多。疾病严重程度和女性性别被确定为这些症状发展和持续的潜在决定因素。结论在相当比例的SARS-CoV-2感染的研究参与者中存在covid后神经精神症状,在高达7.6%的参与者中持续6个月。
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引用次数: 9
Lowered oxygen saturation and increased body temperature in acute COVID-19 largely predict chronic fatigue syndrome and affective symptoms due to LONG COVID: a precision nomothetic approach 急性新冠肺炎患者的血氧饱和度降低和体温升高在很大程度上预测了长期COVID引起的慢性疲劳综合征和情感症状:一种精确的无意识方法
IF 3.8 4区 医学 Q1 Medicine Pub Date : 2022-04-12 DOI: 10.1101/2022.04.10.22273660
Dhurgham Shihab Al-Hadrawi, Haneen Tahseen Al-Rubaye, A. Almulla, H. Al-Hakeim, Michael Maes
Background: Long coronavirus disease 2019 (LC) is a chronic sequel of acute COVID-19. The exact pathophysiology of the affective, chronic fatigue and physiosomatic symptoms labeled as physio-affective phenome of LC has remained elusive. Objective: The current study aims to delineate the effects of oxygen saturation (SpO2) and body temperature during the acute phase on the physio-affective phenome of LC. Method: We recruited 120 LC patients and 36 controls. For all participants, we assessed the lowest SpO2 and peak body temperature during acute COVID-19, and the Hamilton Depression and Anxiety Rating Scale (HAMD/HAMA) and Fibro Fatigue (FF) scales 3 to 4 months later. Results: Lowered SpO2 and increased body temperature during the acute phase and female sex predict 60.7% of the variance in the physio-affective phenome of LC. Using unsupervised learning techniques we were able to delineate a new endophenotype class, which comprises around 26.7% of the LC patients and is characterized by very low SpO2 and very high body temperature, and depression, anxiety, chronic fatigue, and autonomic and gastro-intestinal symptoms scores. Single latent vectors could be extracted from both biomarkers, depression, anxiety and FF symptoms or from both biomarkers, insomnia, chronic fatigue, gastro-intestinal and autonomic symptoms. Conclusion: The newly constructed endophenotype class and pathway phenotypes indicate that the physio-affective phenome of LC is at least in part the consequence of the pathophysiology of acute COVID-19, namely the combined effects of lowered SpO2, increased body temperature and the associated immune-inflammatory processes and lung lesions.
背景:2019年长期冠状病毒病(LC)是急性新冠肺炎的慢性后遗症。被标记为LC生理-情感现象的情感性、慢性疲劳和生理-躯体症状的确切病理生理学仍然难以捉摸。目的:本研究旨在探讨急性期血氧饱和度(SpO2)和体温对LC生理情感现象的影响。方法:我们招募了120名LC患者和36名对照者。对于所有参与者,我们评估了急性新冠肺炎期间的最低SpO2和最高体温,以及3-4个月后的汉密尔顿抑郁和焦虑评定量表(HAMD/HAMA)和纤维疲劳(FF)量表。结果:急性期SpO2降低和体温升高以及女性预测了LC生理-情感现象60.7%的方差。使用无监督学习技术,我们能够描绘出一个新的内表型类别,该类别约占LC患者的26.7%,其特征是SpO2非常低和体温非常高,以及抑郁、焦虑、,慢性疲劳以及自主神经和胃肠道症状评分。单个潜在载体可以从抑郁、焦虑和FF症状这两种生物标志物中提取,也可以从失眠、慢性疲劳、胃肠道和自主神经症状这两个生物标志物提取。结论:新构建的内表型类别和途径表型表明,LC的生理有效现象至少部分是急性新冠肺炎病理生理学的结果,即SpO2降低、体温升高以及相关免疫炎症过程和肺部病变的联合作用。
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引用次数: 14
The impact of social isolation due to the COVID-19 pandemic on patients with dementia and caregivers. 新冠肺炎大流行导致的社会隔离对痴呆症患者和护理人员的影响。
IF 3.8 4区 医学 Q1 Medicine Pub Date : 2022-04-04 DOI: 10.1017/neu.2022.12
Riccardo Manca, Matteo De Marco, Amanda Colston, V. Raymont, J. Amin, R. Davies, Pramod Kumar, G. Russell, D. Blackburn, A. Venneri
OBJECTIVESocial distancing to limit COVID-19 transmission has led to extensive lifestyle changes, including for people with dementia (PWD). The aim of this study, therefore, was to assess the impact of lockdown on the mental health of PWD and their carers.METHODSForty-five carers of PWD completed a telephone interview during the baseline assessment of the SOLITUDE study to gather information on life conditions and changes in symptoms of PWD during lockdown. Associations between changes in symptoms of PWD and carers' concerns and mental health were investigated.RESULTSAbout 44% of carers experienced anxiety and irritability and reported changes in behavioural and cognitive symptoms in PWD. These changes were associated with worse carers' mental health and concerns about faster disease progression (χ2 = 13.542, p < 0.001).CONCLUSIONCOVID-19-related social isolation has had a negative impact on patients' and carers' mental health. Potential long-term neurocognitive consequences require further investigation.
保持社交距离以限制COVID-19的传播已导致广泛的生活方式改变,包括痴呆症患者。因此,本研究的目的是评估封锁对残疾人士及其照顾者心理健康的影响。方法在孤独研究的基线评估期间,45名PWD护理人员完成了电话访谈,以收集有关禁闭期间PWD生活状况和症状变化的信息。调查了PWD症状变化与护理人员关注和心理健康之间的关系。结果约44%的护理人员经历焦虑和易怒,并报告在PWD中行为和认知症状发生变化。这些变化与护理人员的心理健康状况较差以及对疾病更快进展的担忧相关(χ2 = 13.542, p < 0.001)。结论新型冠状病毒肺炎相关社会隔离对患者和护理人员的心理健康产生了负面影响。潜在的长期神经认知后果需要进一步调查。
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引用次数: 1
Dietary supplementation with casein glycomacropeptide, leucine and tryptophan reduces plasma amino acid levels in men. 膳食中补充酪蛋白、糖宏肽、亮氨酸和色氨酸可降低男性血浆氨基酸水平。
IF 3.8 4区 医学 Q1 Medicine Pub Date : 2022-04-01 Epub Date: 2021-10-20 DOI: 10.1017/neu.2021.34
Erik Roj Larsen, Anette Juel, Erik Jensen, Tristan R Hollyer, Gregers Wegener

Background: The treatment of mania in bipolar disorders needs to be more efficient, as the manic condition creates severe problems for the patient when it comes to work, finances, relationships and health. This proof-of-concept study examines to what extent casein glycomacropeptide (CGMP) may reduce the precursors of dopamine, phenylalanine and tyrosine, in plasma, and therefore be a potential new intervention to treat acute manic episodes.

Method: The study was designed as a double-blind randomised dose-response study of CGMP (with added leucine and tryptophan) in 15 healthy men, receiving 3 different doses of CGMP with an interval of at least 14 days.

Results: Administration of CGMP produced a dose-dependent depletion of plasma aromatic amino acids. The total area under the curve of plasma ratios of phenylalanine-tyrosine compared to the level of leucine-isoleucine-valine--tryptophan was CGMP (20 g): 3.648 [SE:0.3281]; CGMP (40 g): 2.368 [SE:0.1858]; and CGMP (60 g)1.887 [SE:0.2591]. A comparison of the groups showed a dose-dependent statistical difference, with a one-way ANOVA summary (Dunnett) F = 11.87, p = 0.0003, CGMP 20 g versus CGMP 40 g, p = 0.0042, CGMP 20 g versus CGMP 60 g, p = 0.0002. No significant side effects were observed.

Conclusions: This study demonstrate CGMP is a well-tolerated and effective mixture, and that 60 g of CGMP produced the highest depletion of plasma aromatic amino acids (phenylalanine and tyrosine). The effect seems to be highest after 3-4 h. We therefore conclude that this dose should be the one considered for future studies involving CGMP in humans.

背景:双相情感障碍患者的躁狂症治疗需要更有效,因为躁狂症在工作、财务、人际关系和健康方面给患者带来了严重的问题。这项概念验证性研究考察了酪蛋白糖宏肽(CGMP)在多大程度上可能减少血浆中多巴胺、苯丙氨酸和酪氨酸的前体,因此可能成为治疗急性躁狂发作的新干预措施。方法:本研究设计为CGMP(添加亮氨酸和色氨酸)的双盲随机剂量-反应研究,在15名健康男性中,接受3种不同剂量的CGMP,间隔至少14天。结果:CGMP使血浆芳香氨基酸呈剂量依赖性耗竭。血浆苯丙氨酸-酪氨酸与亮氨酸-异亮氨酸-缬氨酸-色氨酸比值曲线下总面积为CGMP (20 g): 3.648 [SE:0.3281];CGMP (40 g): 2.368 [SE:0.1858];CGMP (60 g)1.887 [SE:0.2591]。组间比较显示剂量相关的统计学差异,单因素方差分析总结(Dunnett) F = 11.87, p = 0.0003, CGMP 20 g对CGMP 40 g, p = 0.0042, CGMP 20 g对CGMP 60 g, p = 0.0002。未观察到明显的副作用。结论:本研究证明CGMP是一种耐受性良好且有效的混合物,60 g CGMP可产生最高的血浆芳香族氨基酸(苯丙氨酸和酪氨酸)消耗。效果似乎在3-4小时后达到最高。因此,我们得出结论,该剂量应考虑用于未来涉及人体CGMP的研究。
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引用次数: 0
Treatment-induced mood switching in affective disorders. 情感性障碍中治疗诱导的情绪转换。
IF 3.8 4区 医学 Q1 Medicine Pub Date : 2022-04-01 Epub Date: 2021-12-27 DOI: 10.1017/neu.2021.47
Siu Wa Tang, Wayne H Tang, Brian E Leonard

Many patients under treatment for mood disorders, in particular patients with bipolar mood disorders, experience episodes of mood switching from one state to another. Various hypotheses have been proposed to explain the mechanism of mood switching, spontaneously or induced by drug treatment. Animal models have also been used to test the role of psychotropic drugs in the switching of mood states. We examine the possible relationship between the pharmacology of psychotropic drugs and their reported incidents of induced mood switching, with reference to the various hypotheses of mechanisms of mood switching.

许多正在接受情绪障碍治疗的患者,特别是双相情绪障碍患者,都会经历情绪从一种状态转换到另一种状态的发作。人们提出了各种各样的假设来解释情绪转换的机制,自发的或由药物治疗诱导的。动物模型也被用来测试精神药物在情绪状态转换中的作用。我们研究了精神药物的药理学和他们报道的诱发情绪转换事件之间可能的关系,参考了情绪转换机制的各种假设。
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引用次数: 4
Sirtuins and neuropeptide y downregulation in Flinders Sensitive Line rat model of depression. 弗林德斯敏感系大鼠抑郁症模型中的Sirtuins和神经肽y下调。
IF 3.8 4区 医学 Q1 Medicine Pub Date : 2022-04-01 Epub Date: 2021-10-20 DOI: 10.1017/neu.2021.36
Miranda Stiernborg, Paschalis Efstathopoulos, Andreas Lennartsson, Catharina Lavebratt, Aleksander A Mathé

Since the NAD+-dependent histone deacetylases sirtuin-1 (SIRT1) and sirtuin-2 (SIRT2) are critically involved in epigenetics, endocrinology and immunology and affect the longevity in model organisms, we investigated their expression in brains of 3-month-old and 14-15 months old rat model of depression Flinders Sensitive Line (FSL) and control Flinders Resistant Line (FRL) rats. In view of the dysregulated NPY system in depression, we also studied NPY in young and old FSL to explore the temporal trajectory of depressive-like-ageing interaction. Sirt1, Sirt2 and Npy mRNA were determined using qRT-PCR in prefrontal cortex (PFC) from young and old FSL and FRL, and in hippocampi from young FSL and FRL. PFC: Sirt1 expression was decreased in FSL (p = 0.001). An interaction between age and genotype was found (p = 0.032); young FSL had lower Sirt1 with respect to both age (p = 0.026) and genotype (p = 0.001). Sirt2 was lower in FSL (p = 0.003). Npy mRNA was downregulated in FSL (p = 0.001) but did not differ between the young and old rat groups. Hippocampus: Sirt1 was reduced in young FSL compared to young FRL (p = 0.005). There was no difference in Sirt2 between FSL and FRL. Npy levels were decreased in hippocampus of young FSL compared to young FRL (p = 0.003). Effects of ageing could not be investigated due to loss of samples. To conclude, i this is the first demonstration that SIRT1 and SIRT2 are changed in brain of FSL, a rat model of depression; ii the changes are age-dependent; iii sirtuins are potential targets for treatment of age-related neurodegenerative diseases.

由于NAD+依赖性组蛋白去乙酰化酶sirtuin-1 (SIRT1)和sirtuin-2 (SIRT2)在模式生物中参与表观遗传学、内分泌学和免疫学并影响寿命,我们研究了它们在3月龄和14-15月龄抑郁弗林德斯敏感系(FSL)和对照弗林德斯耐药系(FRL)大鼠大脑中的表达。鉴于NPY系统在抑郁症中的失调,我们还研究了年轻和老年FSL的NPY,以探索抑郁样衰老相互作用的时间轨迹。采用qRT-PCR方法检测年轻、年老FSL和FRL的前额叶皮层(PFC)以及年轻FSL和FRL海马中的Sirt1、Sirt2和Npy mRNA。PFC: FSL中Sirt1表达降低(p = 0.001)。年龄与基因型之间存在交互作用(p = 0.032);年轻FSL的Sirt1相对于年龄(p = 0.026)和基因型(p = 0.001)都较低。FSL患者Sirt2较低(p = 0.003)。Npy mRNA在FSL中下调(p = 0.001),但在年轻和年老大鼠组之间没有差异。海马:与年轻FRL相比,年轻FSL的Sirt1减少(p = 0.005)。FSL和FRL之间Sirt2没有差异。与年轻FRL相比,年轻FSL海马中Npy水平降低(p = 0.003)。由于样品的损失,老化的影响无法进行研究。综上所述,这是首次证实抑郁症大鼠模型FSL的大脑中SIRT1和SIRT2发生了变化;这些变化与年龄有关;sirtuins是治疗与年龄相关的神经退行性疾病的潜在靶点。
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引用次数: 2
Mental well-being, health, and locus of control in Danish adults before and during COVID-19. 新冠肺炎前后丹麦成年人的心理健康、健康和控制点。
IF 3.8 4区 医学 Q1 Medicine Pub Date : 2022-04-01 Epub Date: 2021-11-24 DOI: 10.1017/neu.2021.37
Hanne Würtzen, Line Helene Clausen, Peter Birkelund Andersen, Ziggi Ivan Santini, Jakob Erkmen, Heidi Frølund Pedersen

Aim: The aim of this study was to investigate the possible impact of the Covid-19 pandemic on general health, mental well-being, and experiences of control compared to pre-pandemic populations. Our hypotheses were that we would observe a significantly lower level of psychological well-being and general health in the 2020 sample compared to the pre-pandemic samples, and that we would observe younger age groups to be the most affected.

Method: Two representative Danish populations (2016, n = 1656) and (2017, n = 3366) were compared to a representative Danish population (2020, n = 1538) sampled during the first lockdown in May 2020. Two-tailed tests of proportions were used to investigate possible differences between samples in proportions reporting poorer mental well-being measured by 5-item World Health Organization Well-Being Index, general health, and internal locus of control.

Results: Younger men (aged 18-24) and younger women (aged 18-44) as well as elderly women (aged 65-74) reported lower mental well-being during the early phase of the pandemic compared to the population from 2016. Both women and men in 2020 reported significantly lower levels of internal locus of control compared to the 2017 sample. This was especially true for younger men and women. There were no statistically significant differences in general health between populations.

Discussion: This study partly supports the hypothesis that the Covid-19 pandemic affected mental well-being negatively among younger persons. However, longitudinal studies are needed to investigate possible long-term effects of the pandemic on mental health and well-being. Further, qualitative studies are needed to investigate the in-depth consequences of Covid-19.

目的:本研究的目的是调查与大流行前人群相比,Covid-19大流行对总体健康、心理健康和控制经历的可能影响。我们的假设是,与大流行前的样本相比,我们将观察到2020年样本中的心理健康和总体健康水平明显较低,并且我们将观察到年轻年龄组受到的影响最大。方法:将两个具有代表性的丹麦人群(2016年,n = 1656)和(2017年,n = 3366)与2020年5月第一次封锁期间抽样的具有代表性的丹麦人群(2020年,n = 1538)进行比较。采用比例双尾检验来调查报告较差心理健康的样本之间可能存在的差异,该比例由世界卫生组织幸福指数、一般健康状况和内部控制点的五项指标衡量。结果:与2016年的人口相比,在大流行的早期阶段,年轻男性(18-24岁)、年轻女性(18-44岁)以及老年女性(65-74岁)报告的心理健康状况较低。与2017年的样本相比,2020年的女性和男性都报告了明显较低的内部控制点水平。这对年轻的男性和女性来说尤其如此。人群之间的总体健康状况没有统计学上的显著差异。讨论:本研究在一定程度上支持了Covid-19大流行对年轻人心理健康产生负面影响的假设。然而,需要进行纵向研究,以调查大流行对心理健康和福祉可能产生的长期影响。此外,需要进行定性研究,以深入调查Covid-19的后果。
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引用次数: 9
期刊
Acta Neuropsychiatrica
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