Acta hepato-gastroenterologica最新文献

Eleven cases of hyperplasia of Brunner's glands are reported including 10 cases of diffuse and nodular type and one case of Brunnerian polyadenomatosis. Histological changes were identified in aspiration biopsy specimens and termed "biopsy indication of hyperplasia of Brunner's glands". Polypoid pattern seen roentgenologically and endoscopically in the case of the adenomatous type was constant whereas in the case of the diffuse and nodular type it was not constant; it is suggested that this is due to irregular contraction of muscularis mucosae disrupted by protruding Brunner's glands. Most patients had epigastric distress; less than half had duodenitis.

In 15 patients (n = 6 without and n = 9 with liver diseases) we measured the plasma disappearance curves after single injections of C 14-glycocholate, calculated the distribution and excretion kinetics on the basis of a 2- and 3-compartmental model and compared the calculated values for the maximal C 14-accumulation within compartment 2 that should correspond to the liver in both compartmental models. The results demonstrate that only the 3-compartmental model reproduces the pathophysiological situation in the patients with liver injuries, namely a decrease of the maximal C 14-accumulation within the liver and an increased C 14-accumulation within the extrahepatoplasmatic compartment. The results therefore confirm our previous studies in healthy patients even for the patient with liver diseases.

Multiseptate gallbladder is an extremely rare anomaly, the number of reported cases not having exceeded ten. In this 37-year-old man with a complaint of occasional nausea, vomiting and abdominal pain, intravenous cholecystography combined with tomography demonstrated a normal size gallbladder with many thin septa. The removed gallbladder had multiple intercommunicating locules divided by thin septa, looking like a honeycomb on the cut surface. The bile contained was dark brown in the neck and much lighter in color in the fundus, suggesting a disturbed bladder function. Histologically, some of the septa lacked the muscularis. He has been free of the previous complaints after surgery. Eight similar cases already documented are reviewed with a discussion on the embryogenetic aspect of this anomaly.

Leucocyte migration inhibition test was used for evaluation of cell-mediated immunity in patients with pernicious anaemia (PA) and simple atrophic gastritis (SAG). As antigens microsomal antigen from gastric mucosa of swine foetus and relatively pure hog intrinsic factor (IF) were used. Significant differences were found between PA and SAG with microsomal antigen, but not with IF. It was concluded, that the microsomal antigen might be more active than IF. This observation could contribute to explane the higher incidence of parietal cell antibody than that of IF antibody in PA patients.

Perfusion of mouse pancreatic slices revealed that continuous exposition with cholecystokinin-pancreazymin (CCK-PZ) provokes an initially high peak of amylase secretion, which is followed by a slow decline in enzyme discharge. A return to the basal secretory level is noticed after about 45 min. Repeated pulse stimulations with CCK-PZ result in a more efficient stimulation of pancreatic amylase release, compared to a continuous stimulation. In the presence of CCK-PZ for 45 min, as well as during a post-stimulatory period of 45 min, a significant depression of L-(U-14C) leucine incorporation into amylase as well as total protein is recorded. In conclusion, in vitro incubated mouse pancreatic slices thus seem to be unable to increase their rate of protein synthesis during and after stimulation of secretion.

The effect of acidification of duodenal contents on splanchnic bloodflow and gastric circulation was investigated in anaesthetized dogs by measuring electromagnetically portal venous and left gastric artery bloodflow and gastric mucosa bloodflow with pertechnetate clearance. Duodenal acidification increased portal venous bloodflow and reduced mesenteric inflow resistance. At the same time bloodflow in the gastric artery and (not significantly) in the mucosa were reduced in consequence of increased inflow resistances.

The concentrations of gastrin were measured by the RIA method in the sera of 121 healthy Greek volunteers of both sexes and of different ABO blood groups, aged 20--70 years. The determinations took place in a fasting state in all the individuals and 10 min and 40 min after a test meal in 42 of them. No significant differences were found in the mean concentrations of gastrin in the fasting state and after the meal between the various ABO groups. There was an increase in the mean concentrations of gastrin in all the groups after the meal. Nevertheless, this was significant 40 min after the meal in the groups A and B whilst in the group O and in the groups A, B and AB considered together this significant increase had appeared already 10 min after the meal.