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Limb saving with regenerative medicine tactics - a case report. 用再生医学策略保肢1例。
Q4 Medicine Pub Date : 2025-01-01 DOI: 10.48095/ccachp2025111
F Contoli Isoldi, L Vieites, A K De Sá Reis, L M Ferreira

Regenerative medicine has gained significant attention due to its diverse strategies for tissue restoration and restructuring. This therapeutic approach combines knowledge from cellular biology, tissue engineering, and translational medicine, providing new hope for treating conditions that previously lacked definitive therapeutic options. Although natural tissue regeneration occurs in some organs, such as the liver, and in superficial epidermal injuries, this process is limited. Tissue regeneration involves replacing damaged cells with cells of the same type, fully restoring tissue structure and function, while healing often results in scar tissue that may not have the same functional properties. Given this limitation, regenerative medicine aims to enhance the body's regenerative capacity. The manipulation of growth factors, such as platelet-derived growth factor and vascular endothelial growth factor, has been shown to increase vascularization and cell proliferation. Autologous fat grafting has emerged as a vital tool in regenerative medicine, demonstrating efficacy in promoting tissue regeneration due to its rich composition of mesenchymal stem cells and growth factors. Case studies illustrate that lipografting can improve wound healing in patients with chronic ulcers and contribute to aesthetic and functional outcomes in breast reconstruction. This study reports a case of a 27-year-old male who sustained severe trauma to his left hand in a car accident, resulting in complex injuries. Despite the potential for amputation, the decision was made to preserve the limb. A series of surgical interventions, including necrotic tissue debridement and lipografting, were conducted over several weeks, resulting in significant tissue regeneration. By the fifth week, the wound bed exhibited adequate granulation tissue, and a skin graft was applied, demonstrating successful integration and functional recovery. This case underscores the potential of regenerative medicine techniques, specifically lipografting, in limb salvage and tissue repair. Further research is needed to enhance understanding and application of these strategies in treating complex wounds and improving patient outcomes.

再生医学因其多种组织修复和重组策略而受到广泛关注。这种治疗方法结合了细胞生物学、组织工程学和转化医学的知识,为治疗以前缺乏明确治疗选择的疾病提供了新的希望。虽然自然组织再生发生在某些器官,如肝脏和浅表表皮损伤中,但这一过程是有限的。组织再生包括用相同类型的细胞替换受损细胞,完全恢复组织结构和功能,而愈合通常会导致疤痕组织,可能不具有相同的功能特性。鉴于这一限制,再生医学旨在增强人体的再生能力。对生长因子,如血小板衍生生长因子和血管内皮生长因子的操纵,已被证明可以增加血管化和细胞增殖。自体脂肪移植已成为再生医学的重要工具,由于其丰富的间充质干细胞和生长因子的组成,显示出促进组织再生的功效。案例研究表明,脂肪移植可以改善慢性溃疡患者的伤口愈合,并有助于乳房重建的美学和功能结果。本研究报告一例27岁男性在车祸中左手严重受伤,导致复杂损伤。尽管有截肢的可能,我们还是决定保留肢体。一系列的手术干预,包括坏死组织清创和脂肪移植,进行了几个星期,导致显著的组织再生。到第五周,伤口床显示出足够的肉芽组织,并应用皮肤移植,显示成功的整合和功能恢复。这个病例强调了再生医学技术,特别是脂肪移植,在肢体修复和组织修复方面的潜力。需要进一步的研究来加强对这些策略在治疗复杂伤口和改善患者预后方面的理解和应用。
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引用次数: 0
Functional outcome of peripheral nerve schwannoma - a case series. 周围神经鞘瘤的功能结局-一个病例系列。
Q4 Medicine Pub Date : 2025-01-01 DOI: 10.48095/ccachp2025116
J K Mishra, A Valsalan, S A Sahu, M De

Schwannomas are the most common peripheral nerve sheath tumors in adults, originating from Schwann cells of the peripheral nerve sheath. These tumors are benign, solitary, non-invasive, and encapsulated, with no gender preference. They are more commonly observed in individuals in their fourth decade of life. In this case series, we present schwannomas arising from various peripheral nerves across different age groups, with varying clinical presentations, and their management without any postoperative functional deficits.

神经鞘瘤是成人最常见的周围神经鞘肿瘤,起源于周围神经鞘的雪旺细胞。这些肿瘤是良性的,孤立的,非侵入性的,包裹性的,没有性别偏好。它们更常见于40岁左右的个体。在这个病例系列中,我们介绍了不同年龄组的各种周围神经产生的神经鞘瘤,具有不同的临床表现,其处理没有任何术后功能缺陷。
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引用次数: 0
From subjective judgment to objective analysis - improving child abuse detection in pediatric burns in the Czech Republic. 从主观判断到客观分析——改善捷克共和国儿童烧伤的儿童虐待检测。
Q4 Medicine Pub Date : 2025-01-01 DOI: 10.48095/ccachp2025137
J Bartková, R Ogawa
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引用次数: 0
Anthropometric study of the ear in the Vietnamese adult population. 越南成人耳部的人体测量学研究。
Q4 Medicine Pub Date : 2025-01-01 DOI: 10.48095/ccachp2025167
N Hong Ha, T T Thanh Huyen, D T Viet Ha

Objective: External ear reconstructive surgery is often needed due to congenital malformations or acquired traumas, which requires surgeons to comprehend ear norms as morphological variations exist between ethnicities. This study presents the first set of anthropometric data specific to the Vietnamese adult ear.

Materials and methods: A cross-sectional study involving 2,000 Vietnamese participants (1,000 women and 1,000 men) aged 18-25 years without a history of ear malformations, trauma, or surgery was conducted. On the left ear, 14 anatomical landmarks were defined, and 13 ear dimensions were measured using a standardized photographic analysis method.

Results: The 13 ear dimensions measured on both genders are ear length, ear breadth, ear length above tragus, ear length below tragus, tragus length, concha length, concha breadth, lobule height, lobule width, distance from the tragus to antihelix, distance from the tragus to helix, the measurement between the posterior point of the tragus and a point of the helix, width of the intertragic incisura and depth of the intertragic incisura. Most notably, mean values of ear length, ear breadth, concha length, and concha breadth in female subjects were found to be 58.70 ± 4.20, 29.75 ± 2.53, 26.87 ± 2.27, and 15.92 ± 2.39, respectively. In males, the corresponding values were 63.11 ± 4.95, 30.81 ± 2.97, 29.02 ± 2.64, and 15.96 ± 2.63, respectively.

Conclusions: Gender-based differences in left ear morphology were observed, with measurements being higher in males for 10 out of 13 variables. Furthermore, our findings highlight distinctive ear dimensions among Vietnamese individuals compared to other ethnic groups. However, since we only studied the left ear, further research should investigate the dimensions of the right ear and assess symmetry between both sides.

目的:外耳重建手术往往是由于先天性畸形或获得性创伤,这就要求外科医生了解耳规范,因为不同种族之间存在形态差异。本研究提出了第一组针对越南成人耳朵的人体测量数据。材料和方法:一项横断面研究涉及2000名越南参与者(1000名女性和1000名男性),年龄在18-25岁之间,无耳部畸形、创伤或手术史。在左耳上,定义了14个解剖标志,并使用标准化的摄影分析方法测量了13个耳朵尺寸。结果:测定的13种耳尺寸分别为:耳长、耳宽、耳屏上耳长、耳屏下耳长、耳屏长、耳甲长、耳甲宽、小叶高、小叶宽、耳屏到反耳线的距离、耳屏到耳线的距离、耳屏后点到耳线一点的距离、耳屏间切牙宽度、耳间切牙深度。女性受试者耳长、耳宽、耳甲长、耳甲宽的平均值分别为58.70±4.20、29.75±2.53、26.87±2.27、15.92±2.39。男性分别为63.11±4.95、30.81±2.97、29.02±2.64、15.96±2.63。结论:观察到基于性别的左耳形态差异,在13个变量中的10个变量中,男性的测量值更高。此外,我们的研究结果突出了越南个体与其他民族相比的独特耳朵尺寸。然而,由于我们只研究了左耳,进一步的研究应该调查右耳的尺寸,并评估两侧的对称性。
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引用次数: 0
Overall and area-specific tactile recovery following different methods of surgical reinnervation in post-mastectomy breast reconstruction - a systematic review and meta-analysis. 不同手术神经移植方法在乳房切除术后乳房重建中的整体和区域特异性触觉恢复-系统回顾和荟萃分析。
Q4 Medicine Pub Date : 2025-01-01 DOI: 10.48095/ccachp2025189
R C Suteja, I G Prawista, A Salim, I K Adiputra, G V Purnama, I P Suryanov, D Junior, I G Diksha, S Christian, G W Samsarga
<p><strong>Background: </strong>Breast cancer is a term that encompasses malignancy of any tissue structurally forming the breast. Due to its high prevalence, breast cancer places a significant burden on both patients and the healthcare system. Treatments such as radiotherapy, chemotherapy, hormonal therapy, and mastectomy are developed. Mastectomy is a lifesaving procedure but can cause decreased aesthetic and functional factors. Recent advances in medical technology have thankfully allowed surgeons to use advanced modalities that enable microscopic reconstruction of tissues, vessels, and nerves, giving sensation to the newly reconstructed breast. Surgical reinnervation is a procedure that describes the restoration of neurological function - both sensory and recovery - towards a body part that is lost or damaged. Reinnervation can be achieved both spontaneously and via surgery, hence termed surgical reinnervation. In this study, we review three surgical reinnervation interventions. First, end-to-end reinnervation comes under the neurorrhaphy group. Neurorrhaphy involves anastomosis of residual nerves in the proximal (healthy) and distal (denervated) tissues. Second, nerve allografts come under nerve transplantation. Third, nerve conduits mimic auto-transplantation but with an artificial conductor instead of a nerve donor. This study aims to measure and compare the overall and area-specific tactile recovery following different methods of surgical reinnervation following post-mastectomy breast reconstruction. Evaluation of the topic: This study is a systematic review and meta-analysis written according to PRISMA (Preferred Reporting Items for Systematic Review and Meta-Analysis) guidelines. Twelve studies used in this review, nine measured the difference between breasts receiving end-to-end nerve coaptation and those receiving no surgical reinnervation. Two studies used allogeneic nerve grafts, while one used polyglycolic acid (PGA) nerve conduit. Coincidentally, these three studies employ Pressure Specified Sensory Device (PSSD) instead of Semmes-Weinstein Monofilament Test to measure tactile recovery. The other nine studies measured tactile recovery using the earlier-found Semmes-Weinstein Monofilament Test (SWMT). Outcome of this study focused on tactile recovery to three interventions. The first group report from end-to-end coaptation, three studies report better outcome compared to flaps without surgical reinnervation. Pooled overall SWMT rod size in breasts with end-to-end nerve coaptation was found to be 3.96 (95% CI 2.96-4.96) with high heterogeneity (I2 94%, P < 0.01). Pooled overall SWMT rod size in breasts without surgical reinnervation was found to be 5.27 (95% CI 4.93-5.60) with high heterogeneity (I2 80%, P < 0.01). The second group report from nerve allograft, two studies report that nerve allograft has a significant effect to tactile recovery. The third group report from nerve conduit, one study report about nerve conduit rei
背景:乳腺癌是一个术语,包括形成乳房的任何组织的恶性肿瘤。由于其高患病率,乳腺癌给患者和医疗保健系统都带来了沉重的负担。放疗、化疗、激素治疗和乳房切除术等治疗方法得到了发展。乳房切除术是挽救生命的手术,但会导致美观和功能因素的下降。庆幸的是,最近医学技术的进步使外科医生能够使用先进的方法,在显微镜下重建组织、血管和神经,给新重建的乳房带来感觉。外科神经移植是一种描述神经功能恢复的程序-包括感觉和恢复-对身体失去或受损的部分。神经再生既可以自发实现,也可以通过手术实现,因此称为外科神经再生。在本研究中,我们回顾了三种外科神经移植干预措施。首先,端到端神经再植属于神经缝合组。神经吻合包括在近端(健康)和远端(无神经支配)组织中残余神经的吻合。第二,同种异体神经移植属于神经移植。第三,神经导管模仿自体移植,但用人工导体代替神经供体。本研究旨在测量和比较乳房切除术后乳房重建后不同手术神经移植方法的整体和区域特异性触觉恢复。主题评价:本研究是根据PRISMA(系统评价和荟萃分析首选报告项目)指南撰写的系统评价和荟萃分析。本综述中使用了12项研究,其中9项测量了接受端到端神经移植和未接受手术神经移植的乳房之间的差异。两项研究使用同种异体神经移植物,一项研究使用聚乙醇酸(PGA)神经导管。巧合的是,这三项研究都采用压力感应装置(PSSD)而不是Semmes-Weinstein单丝测试来测量触觉恢复。其他九项研究使用早期发现的semes - weinstein单丝测试(SWMT)来测量触觉恢复。本研究的结果主要集中在三种干预措施下的触觉恢复。第一组报告了端到端适应,三个研究报告了与没有手术神经移植的皮瓣相比更好的结果。在端到端神经覆盖的乳房中,SWMT棒的总大小为3.96 (95% CI 2.96-4.96),异质性高(I2 94%, P < 0.01)。未行手术再神经移植的乳腺SWMT总棒大小为5.27 (95% CI 4.93-5.60),异质性较高(I2 80%, P < 0.01)。第二组报道来自同种异体神经移植,两项研究报道同种异体神经移植对触觉恢复有显著效果。第三组从神经导管报道,一组关于神经导管再支配的研究报道。本研究的结果低于端到端神经适应。然后,我们进行了区域特异性分析,发现最大的SWMT杆尺寸通常在皮瓣乳头区域。在皮瓣乳头区域端到端覆盖后的SWMT棒大小的合并平均值(95% CI)为4.39 (95% CI 3.70-5.09),而未接受手术神经移植的SWMT棒大小为5.45 (95% CI 4.93-5.97)。总的来说,非皮瓣区域的平均棒大小比重建乳房要小得多。结论:接受和未接受手术神经重建的乳房整体感觉恢复有显著差异,尤其是接受端到端融合的乳房。区域特异性分析发现,这种差异在乳房切除术后皮肤的上内侧部分尤为显著。需要进一步研究其他手术神经移植方法的恢复情况,特别是端侧吻合、侧侧吻合、神经化、导管吻合和神经移植。
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引用次数: 0
Exploring the potential of MRI studies in assessing risks during arthroscopy - insights on maxillary artery encounter. 探讨MRI研究在关节镜检查中评估风险的潜力-上颌动脉接触的见解。
Q4 Medicine Pub Date : 2025-01-01 DOI: 10.48095/ccachp2025106
B Borza, K Glinska, P Kizek

The anatomy and variability of the maxillary artery have been extensively studied through cadaveric dissections and CT angiography, revealing diverse courses of its terminal branches. These studies underscore the importance of understanding regional anatomy, particularly in surgical contexts such as intraoral vertical ramus osteotomy and temporomandibular joint (TMJ) arthroplasty, where proximity to the maxillary artery in the infratemporal fossa poses risks of complications. MRI offers distinct advantages in visualizing soft tissues critical to TMJ function, surpassing conventional imaging modalities like orthopantomography in providing detailed anatomical insights. This study aims to assess the risk of iatrogenic damage to the maxillary artery during arthroscopic procedures using MRI scans. A total of 42 patients, comprising both sexes and varying ages, underwent MRI at the Department of Maxillofacial Surgery, University Hospital Louis Pasteur in Košice. Imaging protocols were standardized on a Toshiba Atlas 1.5 Tesla MRI scanner, ensuring consistent quality with a slice thickness of 6 mm and standardized imaging matrices. Measurements of the maxillary artery's proximity to anatomical landmarks were conducted in axial and parasagittal sections to delineate precise anatomical relationships.

通过尸体解剖和CT血管造影,对上颌动脉的解剖结构和变异性进行了广泛的研究,揭示了其末端分支的不同路线。这些研究强调了了解区域解剖学的重要性,特别是在手术背景下,如口腔内垂直支截骨术和颞下颌关节(TMJ)置换术,在颞下窝靠近上颌动脉会带来并发症的风险。MRI在显示对TMJ功能至关重要的软组织方面具有明显的优势,在提供详细的解剖信息方面优于传统的成像方式,如正体层析成像。本研究旨在通过MRI扫描评估关节镜手术对上颌动脉医源性损伤的风险。共有42名患者,包括男女和不同年龄,在Košice路易斯巴斯德大学医院颌面外科接受了核磁共振成像。成像方案在东芝Atlas 1.5 Tesla MRI扫描仪上标准化,确保了6mm切片厚度和标准化成像矩阵的一致质量。测量上颌动脉接近解剖标志进行轴和副矢状面切片,以描绘精确的解剖关系。
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引用次数: 0
Surgical management of accessory breast tissue: liposuction and mastectomy in axillary localization - a case series. 副乳腺组织的手术处理:腋窝定位的吸脂和乳房切除术-一个病例系列。
Q4 Medicine Pub Date : 2025-01-01 DOI: 10.48095/ccachp2025127
D Ar-Reyouchi, S Saoud, M Benlili, G Charkaoui Belmaati, A A Oufkir

Supernumerary breasts are a rare congenital malformation that can cause physical and psychological problems such as pain, infection, bleeding and aesthetic discomfort. In this article, we present a series of cases with bilateral axillary supernumerary breasts who were treated with liposuction and mastectomy, with satisfactory results. We also discuss the different surgical techniques available for the treatment of supernumerary breasts and their respective advantages and disadvantages.

多余乳房是一种罕见的先天性畸形,会导致身体和心理问题,如疼痛、感染、出血和审美不适。在本文中,我们报告了一系列双侧腋下多余乳房的病例,他们接受了吸脂和乳房切除术,取得了令人满意的结果。我们也讨论了不同的手术技术可用于治疗多余的乳房和各自的优点和缺点。
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引用次数: 0
Landmarks in facial reanimation - a bibliometric analysis of the 50 most cited papers in dynamic facial reconstruction. 面部重建的里程碑——动态面部重建中50篇被引用最多的论文的文献计量学分析。
Q4 Medicine Pub Date : 2025-01-01 DOI: 10.48095/ccachp202555
J E Telich-Tarriba, A Rivera Del Río-Hernández, R Esquiliano-Raya, X González-López, C Domínguez Suárez

Background: Advances in the field of facial reanimation surgery have resulted in an increase in the quantity of published research in the international literature. The aim of this work is to provide the reader a synthesized view of the most influential themes, articles and authors in this field.

Material and methods: We searched the Clarivate Analytics Web of Science Citation Index to identify the 50 most cited papers in dynamic facial reanimation in the past 70 years. Data regarding article title, authors, year of publication, total citations and citation index was obtained. Results are presented using descriptive statistics.

Results: The most cited articles were distributed in 16 journals. Plastic and Reconstructive Surgery had the highest number of highly cited works with 27 articles, followed by JPRAS (5 papers) and the Journal of Neurosurgery (4 papers). The United States contributed most (17 papers), followed by Canada and Japan (6 each). Dr. Julia K. Terzis was the most cited author (7 works). Case series and comparative studies were the most prevalent type of article published (96%) from 1953 to 2015. The most cited paper focused on free functional muscle transfer (FFMT). Most articles were level IV research, with a mean citation index of 5.27 ± 2.85.

Conclusion: This collection offers a clear overview of the key milestones and advancements in the field. We expect it serves as a practical resource for clinicians and researchers striving to advance the science and practice of facial reanimation surgery.

背景:面部再生手术领域的进步导致国际文献中发表的研究数量增加。这项工作的目的是为读者提供这个领域最具影响力的主题、文章和作者的综合观点。材料和方法:我们检索了Clarivate Analytics Web of Science引文索引,以确定过去70年来被引用最多的50篇动态面部再生论文。获得文章标题、作者、发表年份、总被引次数和引文索引等数据。结果采用描述性统计。结果:被引文章最多的期刊有16种。高被引论文数量最多的是Plastic and Reconstructive Surgery(27篇),其次是JPRAS(5篇)和Journal of Neurosurgery(4篇)。美国贡献最多(17篇),其次是加拿大和日本(各6篇)。被引用次数最多的作者是Dr. Julia K. Terzis(7篇)。从1953年到2015年,病例系列和比较研究是发表最多的文章类型(96%)。被引最多的论文集中在自由功能性肌肉转移(FFMT)。大多数文献为ⅳ级研究,平均被引指数为5.27±2.85。结论:本系列提供了该领域关键里程碑和进展的清晰概述。我们希望它能成为临床医生和研究人员努力推进面部再生手术科学和实践的实用资源。
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引用次数: 0
Comparison of lymphovenous anastomosis and vascularized lymph node transfer in lymphedema treatment - a literature review. 淋巴静脉吻合与血管化淋巴结转移治疗淋巴水肿的比较——文献综述。
Q4 Medicine Pub Date : 2025-01-01 DOI: 10.48095/ccachp202542
S Theiner, M Lacková, R Russo, Z Dvořák, B Lipový, M Knoz

Background: Lymphovenous anastomosis (LVA) and vascularized lymph node transfer (VLNT) are both accepted microsurgical treatment options for lymphedema. This article summarises and analyses recent data on outcomes associated with LVA and VLNT for lymphedema treatment at varying degrees of severity.

Methods: Literature research was conducted in the PubMed and Embase Ovid database to extract articles published through March 2024. The included studies report data on objective and subjective improvement in lymphedema after physiological surgical procedures as LVA and VLNT. Extracted data comprised number of patients, affected limbs, staging of the disease, duration of the follow up period, objective and subjective improvement and percentage of discontinuation of compression garments.

Results: A total of 23 articles were included in this article, representing 1,944 patients suffering from either primary or secondary lymphedema. The lymphedema stages were classified by classification of International Society of Lymphedema (ISL stage) or Campisi stage and range from stage I to III, as well as prophylactic indication for surgery. The follow-up duration ranged from 3 months to 8 years. Objective improvement was achieved in 82.76-100% and measured in circumferential reduction rate and reduction of cellulitis episodes. In 80-100% of the patient's subjective improvement was seen, which was measured in quality of life and personal feedback. The percentage of patients able to discontinue the use of compression garments ranges from 0 to 100%, while others were able to reduce the total time of wearing.

Conclusion: LVA and VLNT are both safe and effective techniques for the surgical treatment of lymphedema in several stages. LVA should be preferred if the lymph vessels preserved its patency, otherwise VLNT might be the therapy of choice. Combinations of various procedures with an appropriate postoperative treatment plan might lead to improved patient outcomes.

背景:淋巴静脉吻合(LVA)和血管化淋巴结转移(VLNT)都是淋巴水肿的显微外科治疗选择。本文总结和分析了最近关于LVA和VLNT治疗不同严重程度淋巴水肿的相关结果的数据。方法:在PubMed和Embase Ovid数据库中进行文献研究,提取截止2024年3月发表的文章。纳入的研究报告了生理手术(如LVA和VLNT)后淋巴水肿的客观和主观改善数据。提取的数据包括患者人数、受影响肢体、疾病分期、随访时间、客观和主观改善以及停止使用压缩服的百分比。结果:本文共纳入23篇文献,共纳入1,944例原发性或继发性淋巴水肿患者。淋巴水肿分期按照国际淋巴水肿学会(International Society of lymphodema, ISL分期)或Campisi分期进行分级,从I期到III期,以及手术的预防指征。随访时间为3个月至8年。目标改善率为82.76-100%,测量了周向减少率和蜂窝织炎发作的减少。在80-100%的患者主观改善被看到,这是衡量生活质量和个人反馈。能够停止使用压缩服的患者百分比从0到100%不等,而其他患者能够减少穿着的总时间。结论:LVA和VLNT是分阶段治疗淋巴水肿的安全有效的手术方法。如果淋巴管保持通畅,应首选LVA,否则可能选择VLNT。各种手术与适当的术后治疗计划的结合可能会改善患者的预后。
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引用次数: 0
The importance of sentinel node biopsy and examination in malignant melanoma of the head and neck. 前哨淋巴结活检检查在头颈部恶性黑色素瘤中的重要性。
Q4 Medicine Pub Date : 2025-01-01 DOI: 10.48095/ccachp2025155
J Jaroš, A Fibír

Background: Malignant melanoma of the head and neck is a highly aggressive tumor with a significant risk of regional and distant metastases. Due to the complex anatomy and rich lymphatic drainage of this area, accurate and timely diagnosis and staging are essential for optimal treatment planning. The sentinel lymph node plays a key role in assessing tumor spread and staging.

Materials and methods: A retrospective study was conducted on 26 patients with head and neck melanoma who underwent sentinel lymph node biopsy at our institution between 2017 and 2023. We evaluated the success rate of sentinel node localization, presence of metastases, and subsequent lymphadenectomy.

Results: Sentinel lymph nodes were successfully identified in 23 patients; 5 had positive findings (3 macrometastases, 1 micrometastasis, 1 isolated tumor cells). Lymphadenectomy was indicated in patients with macrometastases, while follow up monitoring was preferred for micrometastases and isolated tumor cells. One patient experienced a complication after lymphadenectomy. Most patients with negative sentinel nodes remained disease-free during follow-up.

Conclusion: Sentinel lymph node biopsy is a crucial tool for staging and treatment decision-making in head and neck malignant melanoma. The procedure's success depends on surgical expertise. Lymphadenectomy is indicated in cases of macrometastases, whereas micrometastases and isolated tumor cells warrant regular follow up. An individualized, multidisciplinary approach is essential.

背景:头颈部恶性黑色素瘤是一种具有高度侵袭性的肿瘤,具有明显的局部和远处转移风险。由于该区域复杂的解剖结构和丰富的淋巴引流,准确及时的诊断和分期对于优化治疗计划至关重要。前哨淋巴结在评估肿瘤的扩散和分期中起着关键作用。材料与方法:回顾性研究2017 - 2023年在我院行前哨淋巴结活检的26例头颈部黑色素瘤患者。我们评估了前哨淋巴结定位的成功率,转移的存在,以及随后的淋巴结切除术。结果:23例患者成功发现前哨淋巴结;阳性5例(大转移3例,微转移1例,分离肿瘤细胞1例)。大转移者行淋巴结切除术,微转移者和分离的肿瘤细胞宜随访监测。1例患者在淋巴结切除术后出现并发症。大多数前哨淋巴结阴性的患者在随访期间保持无病。结论:前哨淋巴结活检是头颈部恶性黑色素瘤分期和治疗决策的重要工具。手术的成功取决于外科医生的专业知识。淋巴结切除术适用于大转移病例,而微转移和分离的肿瘤细胞需要定期随访。个性化的、多学科的方法是必不可少的。
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Acta chirurgiae plasticae
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