Kynurenic acid (KYNA) has been attributed many beneficial properties, such as antioxidant, antiproliferative, anti-inflammatory, and anti-obesogenic, as it is believed to affect metabolism and weight gain. A rapid and simple HPLC-MS/MS method for the determination of kynurenic acid (KYNA) in honey has been developed. HPLC-MS/MS system allowed us to perform the analyzes without any special extraction or treatment of the samples. The study was carried out on different honeys: Chestnut (C), Linden (L), Acacia (A), Spruce (S), Silver Fir (SF), Forest (Fo) and Flower (F). The highest mean concentration, 682 μg/g, was determined for chestnut honey, making it one of the foods with the highest KYNA content.
{"title":"Direct Determination of Kynurenic Acid with HPLC-MS/MS Method in Honey","authors":"Anže Pavlin, M. Pompe, D. Kočar","doi":"10.17344/acsi.2023.8079","DOIUrl":"https://doi.org/10.17344/acsi.2023.8079","url":null,"abstract":"Kynurenic acid (KYNA) has been attributed many beneficial properties, such as antioxidant, antiproliferative, anti-inflammatory, and anti-obesogenic, as it is believed to affect metabolism and weight gain. A rapid and simple HPLC-MS/MS method for the determination of kynurenic acid (KYNA) in honey has been developed. HPLC-MS/MS system allowed us to perform the analyzes without any special extraction or treatment of the samples. The study was carried out on different honeys: Chestnut (C), Linden (L), Acacia (A), Spruce (S), Silver Fir (SF), Forest (Fo) and Flower (F). The highest mean concentration, 682 μg/g, was determined for chestnut honey, making it one of the foods with the highest KYNA content.","PeriodicalId":7122,"journal":{"name":"Acta Chimica Slovenica","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2023-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48960784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Şehnaz Balkır, Ö. Hazman, L. Aksoy, M. Yılmaz, Oğuz Çakır, R. Kara, I. Erol
Antioxidant activity, antimicrobial potency and components of the aerial parts (leaf, stem, flower and mixture) of Salvia tomentosa Miller were determined qualitatively and quantitatively in this study. Aqueous extracts of Salvia tomentosa (ST) were prepared by using the flower, leaf and stem parts and all the above-ground parts of the plant (flower-leafstem mixture) for this purpose. The radical scavenging activity, total antioxidant/oxidant status, antimicrobial potential, phenolic substances and qualitative/quantitative analyzes of the components in the extracts were determined. ST-stem phenolic acid amount (599 ± 34 mg gallic acid equivalent (GAE)/g extract) was found to be close to the standard substance caffeic acid (651 ±3 1 mg GAE/g extract). Total antioxidant status of ST-mix (3.4 ± 0.1 mmol Trolox Equiv./L) and ST-stem (3.4 ± 0.1 mmol Trolox Equiv./L) and natural antioxidant Vitamin C (3.6 ± 0.1 mmol Trolox Equiv./L) were not statistically different. The extract produced by using S. tomentosa aerial parts (flower-stem-leaf) showed stronger antioxidant and antimicrobial activity than the aqueous extracts obtained separately from the flower, stem and leaf of the plant. However, it was determined that the components of the separately prepared flower, stem and leaf extracts and the extract components obtained from the aerial parts were largely similar. At the same time, it was observed that there were significant differences in the presence of these components.
{"title":"Phytochemical Profile, Antioxidant and Antimicrobial Potency of Aerial Parts of Salvia Tomentosa Miller","authors":"Şehnaz Balkır, Ö. Hazman, L. Aksoy, M. Yılmaz, Oğuz Çakır, R. Kara, I. Erol","doi":"10.17344/acsi.2023.8008","DOIUrl":"https://doi.org/10.17344/acsi.2023.8008","url":null,"abstract":"Antioxidant activity, antimicrobial potency and components of the aerial parts (leaf, stem, flower and mixture) of Salvia tomentosa Miller were determined qualitatively and quantitatively in this study. Aqueous extracts of Salvia tomentosa (ST) were prepared by using the flower, leaf and stem parts and all the above-ground parts of the plant (flower-leafstem mixture) for this purpose. The radical scavenging activity, total antioxidant/oxidant status, antimicrobial potential, phenolic substances and qualitative/quantitative analyzes of the components in the extracts were determined. ST-stem phenolic acid amount (599 ± 34 mg gallic acid equivalent (GAE)/g extract) was found to be close to the standard substance caffeic acid (651 ±3 1 mg GAE/g extract). Total antioxidant status of ST-mix (3.4 ± 0.1 mmol Trolox Equiv./L) and ST-stem (3.4 ± 0.1 mmol Trolox Equiv./L) and natural antioxidant Vitamin C (3.6 ± 0.1 mmol Trolox Equiv./L) were not statistically different. The extract produced by using S. tomentosa aerial parts (flower-stem-leaf) showed stronger antioxidant and antimicrobial activity than the aqueous extracts obtained separately from the flower, stem and leaf of the plant. However, it was determined that the components of the separately prepared flower, stem and leaf extracts and the extract components obtained from the aerial parts were largely similar. At the same time, it was observed that there were significant differences in the presence of these components.","PeriodicalId":7122,"journal":{"name":"Acta Chimica Slovenica","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2023-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42716355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. M. Anshar, Bulkis Musa, Muhammad Ayaz, S. Kasim, I. Raya, A. Ramírez-Coronel, S. Chowdhury, R. Zabibah, Rosario Mireya Romero-Parra, Luis Andres Barboza-Arenas, Yasser Fakri Mustafa, A. H. Al-Khafaji
Corrosion and scaling are among the problems that may arise when storing water in tanks. Several factors affect the corrosion and scaling of water, which include pH, temperature, alkalinity, Ca2+ hardness, TDS, concentrations of Cl–, SO42–, CO32–, and HCO3–. Also, several indices can be measured using these properties such as the Langelier saturation index, Ryznar index, Aggressive index, Larson, Scold index, water quality index, and Puckorius index. These indicators determine the degree of corrosiveness and sedimentation of water. The purpose of this review article was to study the impact of various factors on the corrosiveness and sedimentation of water. To this end, different sources of water in different countries were studied and the impact of physical and chemical parameters on their corrosiveness was investigated. Also, the reaction mechanism of water corrosion inside the pipe was studied. Finally, practical and constructive suggestions were presented to solve the problems of corrosion and sedimentation of desalination water.
{"title":"A Critical Review on Corrosion and Fouling of Water in Water Distribution Networks and Their Control","authors":"A. M. Anshar, Bulkis Musa, Muhammad Ayaz, S. Kasim, I. Raya, A. Ramírez-Coronel, S. Chowdhury, R. Zabibah, Rosario Mireya Romero-Parra, Luis Andres Barboza-Arenas, Yasser Fakri Mustafa, A. H. Al-Khafaji","doi":"10.17344/acsi.2022.7939","DOIUrl":"https://doi.org/10.17344/acsi.2022.7939","url":null,"abstract":"Corrosion and scaling are among the problems that may arise when storing water in tanks. Several factors affect the corrosion and scaling of water, which include pH, temperature, alkalinity, Ca2+ hardness, TDS, concentrations of Cl–, SO42–, CO32–, and HCO3–. Also, several indices can be measured using these properties such as the Langelier saturation index, Ryznar index, Aggressive index, Larson, Scold index, water quality index, and Puckorius index. These indicators determine the degree of corrosiveness and sedimentation of water. The purpose of this review article was to study the impact of various factors on the corrosiveness and sedimentation of water. To this end, different sources of water in different countries were studied and the impact of physical and chemical parameters on their corrosiveness was investigated. Also, the reaction mechanism of water corrosion inside the pipe was studied. Finally, practical and constructive suggestions were presented to solve the problems of corrosion and sedimentation of desalination water.","PeriodicalId":7122,"journal":{"name":"Acta Chimica Slovenica","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2023-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43522633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Muhammad Mohsin Tahir, Muhammad Ashfaq, Akbar Ali, Chin‐Hung Lai, B. Rao, K. Munawar, Irshad Ali Shahid
The anilide compound named (Z)-4-(2-methoxy-4-nitrophenyl)amino)-4-oxobut-2-enoic acid (MAOA) has been synthesized by the chemical reaction of 2-methoxy-4-nitroaniline and maleic anhydride in ethyl acetate. The synthesized compound was characterized by elemental analysis, FT-IR and UV-Vis spectroscopy, and TGA/DSC technique. Furthermore, the crystal structure was analyzed by the single crystal X-ray diffraction (SC XRD) technique. The supramolecular assembly of MAOA in terms of non-covalent interactions was explored by Hirshfeld surface analysis. Void analysis inferred that MAOA is expected to have good mechanical properties. The crystal packing environment was further investigated by interaction energy between molecular pairs and energy frameworks. Moreover, the result of the gas-phase DFT study showed that there is an intramolecular N–H···O and O–H···O hydrogen bond in MAOA due to the distance between D and A being smaller than the sum of their van der Waals radii. The result of the QTAIM study showed that there should also be an intramolecular CH···O hydrogen bond with a strength of 3.40 kcal/mol in MAOA.
{"title":"Synthesis, SC XRD Based Structure Elucidation, Supramolecular Assembly Exploration Via Hirshfeld Surface Analysis, Computational and QTAIM Study of Functionalized Anilide","authors":"Muhammad Mohsin Tahir, Muhammad Ashfaq, Akbar Ali, Chin‐Hung Lai, B. Rao, K. Munawar, Irshad Ali Shahid","doi":"10.17344/acsi.2023.8108","DOIUrl":"https://doi.org/10.17344/acsi.2023.8108","url":null,"abstract":"The anilide compound named (Z)-4-(2-methoxy-4-nitrophenyl)amino)-4-oxobut-2-enoic acid (MAOA) has been synthesized by the chemical reaction of 2-methoxy-4-nitroaniline and maleic anhydride in ethyl acetate. The synthesized compound was characterized by elemental analysis, FT-IR and UV-Vis spectroscopy, and TGA/DSC technique. Furthermore, the crystal structure was analyzed by the single crystal X-ray diffraction (SC XRD) technique. The supramolecular assembly of MAOA in terms of non-covalent interactions was explored by Hirshfeld surface analysis. Void analysis inferred that MAOA is expected to have good mechanical properties. The crystal packing environment was further investigated by interaction energy between molecular pairs and energy frameworks. Moreover, the result of the gas-phase DFT study showed that there is an intramolecular N–H···O and O–H···O hydrogen bond in MAOA due to the distance between D and A being smaller than the sum of their van der Waals radii. The result of the QTAIM study showed that there should also be an intramolecular CH···O hydrogen bond with a strength of 3.40 kcal/mol in MAOA.","PeriodicalId":7122,"journal":{"name":"Acta Chimica Slovenica","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2023-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46312603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The aim of this study is to investigate first-year university students’ misconceptions in chemical kinetics by analysing data obtained from the four-tier diagnostic instrument of chemical kinetics (FTDICK). 335 first-year chemistry students from two Indonesian and one UK universities participated in this study. The procedure described here is the first of its type to ensure those misconceptions are genuine. Numerous genuine misconceptions within chemical kinetics were revealed among first-year chemistry undergraduates. Although many of the misconceptions found here concur with those results previously published using other instruments, some novel findings were uncovered. These misconceptions can be attributed to a variety of factors including mathematical weakness, carelessness and difficulty in interpreting and extracting information from diagrams, graphs and other non-textual information. On the basis of the results from this study we make some recommendations for improving the effectiveness of chemical kinetics’ teaching at this level.
{"title":"Uncovering Students’ Genuine Misconceptions: Evidence to Inform the Teaching of Chemical Kinetics","authors":"Habiddin Habiddin, E. Page","doi":"10.17344/acsi.2022.7880","DOIUrl":"https://doi.org/10.17344/acsi.2022.7880","url":null,"abstract":"The aim of this study is to investigate first-year university students’ misconceptions in chemical kinetics by analysing data obtained from the four-tier diagnostic instrument of chemical kinetics (FTDICK). 335 first-year chemistry students from two Indonesian and one UK universities participated in this study. The procedure described here is the first of its type to ensure those misconceptions are genuine. Numerous genuine misconceptions within chemical kinetics were revealed among first-year chemistry undergraduates. Although many of the misconceptions found here concur with those results previously published using other instruments, some novel findings were uncovered. These misconceptions can be attributed to a variety of factors including mathematical weakness, carelessness and difficulty in interpreting and extracting information from diagrams, graphs and other non-textual information. On the basis of the results from this study we make some recommendations for improving the effectiveness of chemical kinetics’ teaching at this level.","PeriodicalId":7122,"journal":{"name":"Acta Chimica Slovenica","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2023-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47980719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Ozone affects blood oxygen transport and the pro-oxidant-antioxidant balance. However, the role of blood formed elements and gas transmitters in these processes still remains unclear. The aim of the present study was to investigate the effect of ozone on oxygen transport and the pro-oxidant-antioxidant balance in a red cell suspension. Methods: The red cell suspension was incubated with ozone at a concentration of 6 mg/l and substances affecting the synthesis of gas transmitters (nitroglycerin, sodium hydrosulfide). Parameters of blood oxygen transport and pro-oxidant-antioxidant balance were determined. Results: The effect of ozone on blood oxygen transport was found which was manifested in an increase in oxygen partial pressure and the degree of oxygenation. The index of hemoglobin –oxygen affinity p50 actual was raised and a shift of the oxyhemoglobin dissociation curve rightwards was noticed. The addition of the gas transmitter donor, nitric oxide, enhanced the effect of this gas on the parameters of oxygen transport in the erythrocyte suspension Conclusion: We found that ozone induced a change in oxygen-binding properties of the erythrocyte suspension which is a mechanism of action of the above gas on the adaptive processes in the body realized directly at the level of erythrocytes.
{"title":"Effect of Ozone on Oxygen Transport and Pro-Oxidant- Antioxidant Balance of Red Blood Cell Suspension","authors":"V. Zinchuk, E. Biletskaya","doi":"10.17344/acsi.2023.8032","DOIUrl":"https://doi.org/10.17344/acsi.2023.8032","url":null,"abstract":"Introduction: Ozone affects blood oxygen transport and the pro-oxidant-antioxidant balance. However, the role of blood formed elements and gas transmitters in these processes still remains unclear. The aim of the present study was to investigate the effect of ozone on oxygen transport and the pro-oxidant-antioxidant balance in a red cell suspension. Methods: The red cell suspension was incubated with ozone at a concentration of 6 mg/l and substances affecting the synthesis of gas transmitters (nitroglycerin, sodium hydrosulfide). Parameters of blood oxygen transport and pro-oxidant-antioxidant balance were determined. Results: The effect of ozone on blood oxygen transport was found which was manifested in an increase in oxygen partial pressure and the degree of oxygenation. The index of hemoglobin –oxygen affinity p50 actual was raised and a shift of the oxyhemoglobin dissociation curve rightwards was noticed. The addition of the gas transmitter donor, nitric oxide, enhanced the effect of this gas on the parameters of oxygen transport in the erythrocyte suspension Conclusion: We found that ozone induced a change in oxygen-binding properties of the erythrocyte suspension which is a mechanism of action of the above gas on the adaptive processes in the body realized directly at the level of erythrocytes.","PeriodicalId":7122,"journal":{"name":"Acta Chimica Slovenica","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2023-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43823309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Reaction of 4-pyridinecarboxaldehyde with 3-hydroxy-4-methoxybenzohydrazide, 4-bromobenzohydrazide and 4-dimethylaminobenzohydrazide, respectively in methanol afforded three new benzohydrazones. They are 3-hydroxy-4-methoxy-N’-(pyridin-4-ylmethylene)benzohydrazide (1), 4-bromo-N’-(pyridin-4-ylmethylene)benzohydrazide (2), and 4-(dimethylamino)-N’-(pyridin-4-ylmethylene)benzohydrazide (3). The compounds have been characterized by elemental analysis, 1H and 13C NMR and IR spectroscopy, as well as single crystal X-ray diffraction. The antibacterial activities of the compounds against E. coli, P. aeruginosa, B. subtilis, and S. aureus were investigated and gave interesting results.
{"title":"Synthesis, Spectroscopic Characterization, Crystal Structures and Antibacterial Activity of Benzohydrazones Derived from 4-Pyridinecarboxaldehyde with Various Benzohydrazides","authors":"Yi Zhou, Wei Li, Z. You","doi":"10.17344/acsi.2023.8123","DOIUrl":"https://doi.org/10.17344/acsi.2023.8123","url":null,"abstract":"Reaction of 4-pyridinecarboxaldehyde with 3-hydroxy-4-methoxybenzohydrazide, 4-bromobenzohydrazide and 4-dimethylaminobenzohydrazide, respectively in methanol afforded three new benzohydrazones. They are 3-hydroxy-4-methoxy-N’-(pyridin-4-ylmethylene)benzohydrazide (1), 4-bromo-N’-(pyridin-4-ylmethylene)benzohydrazide (2), and 4-(dimethylamino)-N’-(pyridin-4-ylmethylene)benzohydrazide (3). The compounds have been characterized by elemental analysis, 1H and 13C NMR and IR spectroscopy, as well as single crystal X-ray diffraction. The antibacterial activities of the compounds against E. coli, P. aeruginosa, B. subtilis, and S. aureus were investigated and gave interesting results.","PeriodicalId":7122,"journal":{"name":"Acta Chimica Slovenica","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2023-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46931623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The objective of the current study was to develop and optimize a novel lyophilized liposomal formulation of anticancer agent carmustine, or bis-chloroethyl nitrosourea (BCNU) for prolonged release that could overcome the dose-dependent side effects and improve its bioavailability at the site of action. The optimization was done using a 32 factorial design approach wherein soya phosphatidylcholine (SPC) and cholesterol (CH) as independent variables. The optimized formulation (F4) exhibited high entrapment efficiency (81.57%) with an average vesicle size of 141.7 nm and a −22.6 mV Zeta potential. In-vitro drug release studies from all formulations revealed that the BCNU was released for up to 36 hours following the Higuchi matrix release model. The TEM, FTIR, DSC, PXRD, and SEM analyses confirm the formation of liposomes. BCNU-loaded nanoliposomal formulation demonstrated prolonged release, suggesting that it could be used to supplement cancer therapy efficiently with a reduction in dose-dependent side effects.
{"title":"Design, Development and Optimization of Carmustine- Loaded Freeze-Dried Nanoliposomal Formulation Using 32 Factorial Design Approach","authors":"Sandip M. Honmane, M. Charde, R. Osmani","doi":"10.17344/acsi.2023.8002","DOIUrl":"https://doi.org/10.17344/acsi.2023.8002","url":null,"abstract":"The objective of the current study was to develop and optimize a novel lyophilized liposomal formulation of anticancer agent carmustine, or bis-chloroethyl nitrosourea (BCNU) for prolonged release that could overcome the dose-dependent side effects and improve its bioavailability at the site of action. The optimization was done using a 32 factorial design approach wherein soya phosphatidylcholine (SPC) and cholesterol (CH) as independent variables. The optimized formulation (F4) exhibited high entrapment efficiency (81.57%) with an average vesicle size of 141.7 nm and a −22.6 mV Zeta potential. In-vitro drug release studies from all formulations revealed that the BCNU was released for up to 36 hours following the Higuchi matrix release model. The TEM, FTIR, DSC, PXRD, and SEM analyses confirm the formation of liposomes. BCNU-loaded nanoliposomal formulation demonstrated prolonged release, suggesting that it could be used to supplement cancer therapy efficiently with a reduction in dose-dependent side effects.","PeriodicalId":7122,"journal":{"name":"Acta Chimica Slovenica","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2023-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46145954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Abdallah, R. Mohareb, M. H. Helal, Mariam M. Abd Elkader
Many new cyclized pyran systems with a potential anti-cancer activity were designed and prepared. Pyran systems showed high reactivity to various chemical reagents. 24 products of the prepared compounds were chosen and tested in (mM) as respectable anticancer factors. The findings revealed that compounds 3b, 6b, and 8 were the widely effective compounds against the three cancer cell lines including A-549 (lung carcinoma), HC-29 (colorectal adenocarcinoma), and MKN-45 (gastric cancer) compared to the standard reference control foretinib.
{"title":"Novel 5,6,7,8-tetrahydrobenzo[b]pyran Derivatives: Synthesis and Anticancer Activity","authors":"A. Abdallah, R. Mohareb, M. H. Helal, Mariam M. Abd Elkader","doi":"10.17344/acsi.2022.7893","DOIUrl":"https://doi.org/10.17344/acsi.2022.7893","url":null,"abstract":"Many new cyclized pyran systems with a potential anti-cancer activity were designed and prepared. Pyran systems showed high reactivity to various chemical reagents. 24 products of the prepared compounds were chosen and tested in (mM) as respectable anticancer factors. The findings revealed that compounds 3b, 6b, and 8 were the widely effective compounds against the three cancer cell lines including A-549 (lung carcinoma), HC-29 (colorectal adenocarcinoma), and MKN-45 (gastric cancer) compared to the standard reference control foretinib.","PeriodicalId":7122,"journal":{"name":"Acta Chimica Slovenica","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2023-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48149567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jian Jiang, Yao Liu, Bo Liu, Yijin Wang, Zhonglu You
Three new zinc(II) complexes, [Zn3(μ2-η1:η1-OAc)2(μ2-η2:η0-OAc)2L2] (1), [Zn3(μ2-η1:η1-OAc)2(μ1,1-N3)(N3)L2] (2), [Zn2(μ1,3-N3)(N3)(H2O)L2] (3), with the Schiff base ligand 4-chloro-2-(((2-(pyrrolidin-1-yl)ethyl)imino)methyl)phenol (HL) have been synthesized and characterized by elemental analysis, IR and UV-Vis spectroscopic studies. Crystal structures of the complexes were confirmed by single crystal X-ray diffraction. Complex 1 is a bidentate acetato, monoatomic bridging acetato, and phenolato co-bridged trinuclear zinc compound. The Zn atoms are in octahedral and square pyramidal coordination. Complex 2 is a bidentate acetato, end-on azido, and phenolato co-bridged trinuclear zinc compound. The Zn atoms are in trigonal bipyramidal and square pyramidal coordination. Complex 3 is an end-to-end azido bridged dinuclear zinc compound. The Zn atoms are in square pyramidal and trigonal bipyramidal coordination. The Schiff base ligands in the complexes coordinate to the Zn atoms through the phenolate oxygen, imino nitrogen and pyrrolidine nitrogen. The complexes have interesting inhibitory activity on Jack bean urease, with IC50 values of 7.1-15.3 μmol·L-1.
{"title":"Synthesis, Crystal Structures and Urease Inhibition of Zinc Complexes Derived from 4-Chloro-2-(((2-(pyrrolidin-1-yl)ethyl)imino)methyl)phenol.","authors":"Jian Jiang, Yao Liu, Bo Liu, Yijin Wang, Zhonglu You","doi":"10.17344/acsi.2022.7969","DOIUrl":"https://doi.org/10.17344/acsi.2022.7969","url":null,"abstract":"Three new zinc(II) complexes, [Zn3(μ2-η1:η1-OAc)2(μ2-η2:η0-OAc)2L2] (1), [Zn3(μ2-η1:η1-OAc)2(μ1,1-N3)(N3)L2] (2), [Zn2(μ1,3-N3)(N3)(H2O)L2] (3), with the Schiff base ligand 4-chloro-2-(((2-(pyrrolidin-1-yl)ethyl)imino)methyl)phenol (HL) have been synthesized and characterized by elemental analysis, IR and UV-Vis spectroscopic studies. Crystal structures of the complexes were confirmed by single crystal X-ray diffraction. Complex 1 is a bidentate acetato, monoatomic bridging acetato, and phenolato co-bridged trinuclear zinc compound. The Zn atoms are in octahedral and square pyramidal coordination. Complex 2 is a bidentate acetato, end-on azido, and phenolato co-bridged trinuclear zinc compound. The Zn atoms are in trigonal bipyramidal and square pyramidal coordination. Complex 3 is an end-to-end azido bridged dinuclear zinc compound. The Zn atoms are in square pyramidal and trigonal bipyramidal coordination. The Schiff base ligands in the complexes coordinate to the Zn atoms through the phenolate oxygen, imino nitrogen and pyrrolidine nitrogen. The complexes have interesting inhibitory activity on Jack bean urease, with IC50 values of 7.1-15.3 μmol·L-1.","PeriodicalId":7122,"journal":{"name":"Acta Chimica Slovenica","volume":"70 1","pages":"139-147"},"PeriodicalIF":1.2,"publicationDate":"2023-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9588133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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