Pub Date : 2001-08-01DOI: 10.1034/J.1600-0420.2001.079004426.X
C. Øgard, C. Øgard, T. Almdal
Thyroid-associated orbitopathy (TAO) developed in relation to estrogen combined with progesterone therapy has not been reported previously. We report a case of a 56-year-old postmenopausal woman who during estrogen/progesterone treatment developed signs and symptoms of orbitopathy. The patient had no previous history of autoimmune- or thyroid disorders. The initial eye symptoms disappeared after withdrawal of hormone replacement therapy. Five years later estrogen/progesterone treatment was re-instituted. The patient had relapse of orbitopathy. The hormones were discontinued and the eye symptoms disappeared again. This suggests that estrogen and/or progesterone could be of some pathogenetic importance in the induction of orbitopathy
{"title":"Thyroid-associated orbitopathy developed during hormone replacement therapy.","authors":"C. Øgard, C. Øgard, T. Almdal","doi":"10.1034/J.1600-0420.2001.079004426.X","DOIUrl":"https://doi.org/10.1034/J.1600-0420.2001.079004426.X","url":null,"abstract":"Thyroid-associated orbitopathy (TAO) developed in relation to estrogen combined with progesterone therapy has not been reported previously. We report a case of a 56-year-old postmenopausal woman who during estrogen/progesterone treatment developed signs and symptoms of orbitopathy. The patient had no previous history of autoimmune- or thyroid disorders. The initial eye symptoms disappeared after withdrawal of hormone replacement therapy. Five years later estrogen/progesterone treatment was re-instituted. The patient had relapse of orbitopathy. The hormones were discontinued and the eye symptoms disappeared again. This suggests that estrogen and/or progesterone could be of some pathogenetic importance in the induction of orbitopathy","PeriodicalId":7152,"journal":{"name":"Acta ophthalmologica Scandinavica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2001-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79320175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2001-08-01DOI: 10.1034/J.1600-0420.2001.079004422.X
J. Pointer
PURPOSE To document the effect upon human foveal vision of changes in the level and polarity of figure-ground contrast under photopic controlled test conditions, with particular emphasis on performance at low contrast levels. METHODS Using a forced-choice psychophysical paradigm, threshold acuity estimates were derived at 9 discrete levels over a near-3 octave contrast range for Landolt ring-type stimuli of either positive or negative polarity. Data were obtained under binocular conditions from 10 young adults, each wearing their optimum low myopic spectacle correction. RESULTS Visual acuity declined linearly with reducing stimulus contrast, the deterioration increasing substantially at <10% figure-ground contrast regardless of stimulus polarity. Performance was slightly (but not statistically significantly) better for positive contrast stimuli. CONCLUSION Irrespective of contrast polarity, a reduction in stimulus figure-ground contrast <10% produces an accelerated decrement in photopic foveal vision compared to the performance at levels >10%. Some clinical and practical implications of this outcome are considered with regard to the examination of patients with normal and compromised visual function.
{"title":"The influence of level and polarity of figure-ground contrast on vision.","authors":"J. Pointer","doi":"10.1034/J.1600-0420.2001.079004422.X","DOIUrl":"https://doi.org/10.1034/J.1600-0420.2001.079004422.X","url":null,"abstract":"PURPOSE\u0000To document the effect upon human foveal vision of changes in the level and polarity of figure-ground contrast under photopic controlled test conditions, with particular emphasis on performance at low contrast levels.\u0000\u0000\u0000METHODS\u0000Using a forced-choice psychophysical paradigm, threshold acuity estimates were derived at 9 discrete levels over a near-3 octave contrast range for Landolt ring-type stimuli of either positive or negative polarity. Data were obtained under binocular conditions from 10 young adults, each wearing their optimum low myopic spectacle correction.\u0000\u0000\u0000RESULTS\u0000Visual acuity declined linearly with reducing stimulus contrast, the deterioration increasing substantially at <10% figure-ground contrast regardless of stimulus polarity. Performance was slightly (but not statistically significantly) better for positive contrast stimuli.\u0000\u0000\u0000CONCLUSION\u0000Irrespective of contrast polarity, a reduction in stimulus figure-ground contrast <10% produces an accelerated decrement in photopic foveal vision compared to the performance at levels >10%. Some clinical and practical implications of this outcome are considered with regard to the examination of patients with normal and compromised visual function.","PeriodicalId":7152,"journal":{"name":"Acta ophthalmologica Scandinavica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2001-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81346158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2001-08-01DOI: 10.1034/J.1600-0420.2001.079004414.X
L. Larsson, E. Nuija
PURPOSE To measure the permeability of the blood-aqueous barrier before and after panretinal photocoagulation (PRP) in patients with proliferative diabetic retinopathy. METHODS Twenty patients with diabetic proliferative retinopathy in one eye and background retinopathy in the other eye were included. PRP was performed in the proliferative eye, while the other eye served as control. Aqueous flare intensity was measured with a laser flare cell meter before, 10 and 90 days after treatment. RESULTS The flare was stable in the control eye with a flare of 4.5+/-2.3, 4.4+/-2.4, and 4.5+/-1.7 photon counts/ms (mean+/-standard deviation) on Day 0, 10 and 90. In the laser treated eye corresponding figures were 5.2+/-2.4, 9.6+/-3.3, and 7.1+/-2.8 photon counts/ms, with a significant increase in aqueous flare at 10 days (p<0.001) and 90 days (p=0.002). CONCLUSION A significant increase in aqueous flare was found 10 days after PRP, indicating a breakdown of the blood-aqueous barrier after retinal laser treatment. The breakdown was still present, however, less pronounced, after 3 months.
{"title":"Increased permeability of the blood-aqueous barrier after panretinal photocoagulation for proliferative diabetic retinopathy.","authors":"L. Larsson, E. Nuija","doi":"10.1034/J.1600-0420.2001.079004414.X","DOIUrl":"https://doi.org/10.1034/J.1600-0420.2001.079004414.X","url":null,"abstract":"PURPOSE\u0000To measure the permeability of the blood-aqueous barrier before and after panretinal photocoagulation (PRP) in patients with proliferative diabetic retinopathy.\u0000\u0000\u0000METHODS\u0000Twenty patients with diabetic proliferative retinopathy in one eye and background retinopathy in the other eye were included. PRP was performed in the proliferative eye, while the other eye served as control. Aqueous flare intensity was measured with a laser flare cell meter before, 10 and 90 days after treatment.\u0000\u0000\u0000RESULTS\u0000The flare was stable in the control eye with a flare of 4.5+/-2.3, 4.4+/-2.4, and 4.5+/-1.7 photon counts/ms (mean+/-standard deviation) on Day 0, 10 and 90. In the laser treated eye corresponding figures were 5.2+/-2.4, 9.6+/-3.3, and 7.1+/-2.8 photon counts/ms, with a significant increase in aqueous flare at 10 days (p<0.001) and 90 days (p=0.002).\u0000\u0000\u0000CONCLUSION\u0000A significant increase in aqueous flare was found 10 days after PRP, indicating a breakdown of the blood-aqueous barrier after retinal laser treatment. The breakdown was still present, however, less pronounced, after 3 months.","PeriodicalId":7152,"journal":{"name":"Acta ophthalmologica Scandinavica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2001-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77320911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2001-08-01DOI: 10.1034/J.1600-0420.2001.079004428.X
E. C. Şener, H. Kıratlı
PURPOSE To report a unique case of a woman who developed simultaneous bilateral maculopathy presumed to result from intake of sertraline hydrochloride, a serotonin reuptake inhibitor. METHODS Full clinical ocular examination, color vision testing, automated static perimetry, electroretinography, electrooculography and fundus fluorescein angiography were performed. Living members of her family were also examined. RESULTS The patient had normal electroretinography and electrooculography results. Automated static perimetry showed generalized reduction of sensitivity and central scotomas. Macular lesions resolved 6 months after discontinuation of sertraline, however, during twenty months of follow-up her visual acuity and abnormalities in other psychophysical tests did not improve. CONCLUSION Patients started on sertraline should be informed of the potential risk of developing maculopathy, and they should be examined regularly to detect possible early alterations.
{"title":"Presumed sertraline maculopathy.","authors":"E. C. Şener, H. Kıratlı","doi":"10.1034/J.1600-0420.2001.079004428.X","DOIUrl":"https://doi.org/10.1034/J.1600-0420.2001.079004428.X","url":null,"abstract":"PURPOSE\u0000To report a unique case of a woman who developed simultaneous bilateral maculopathy presumed to result from intake of sertraline hydrochloride, a serotonin reuptake inhibitor.\u0000\u0000\u0000METHODS\u0000Full clinical ocular examination, color vision testing, automated static perimetry, electroretinography, electrooculography and fundus fluorescein angiography were performed. Living members of her family were also examined.\u0000\u0000\u0000RESULTS\u0000The patient had normal electroretinography and electrooculography results. Automated static perimetry showed generalized reduction of sensitivity and central scotomas. Macular lesions resolved 6 months after discontinuation of sertraline, however, during twenty months of follow-up her visual acuity and abnormalities in other psychophysical tests did not improve.\u0000\u0000\u0000CONCLUSION\u0000Patients started on sertraline should be informed of the potential risk of developing maculopathy, and they should be examined regularly to detect possible early alterations.","PeriodicalId":7152,"journal":{"name":"Acta ophthalmologica Scandinavica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2001-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74903831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2001-08-01DOI: 10.1034/J.1600-0420.2001.079004431.X
O. Haugen
{"title":"Management of strabismus and amblyopia. A practical guide","authors":"O. Haugen","doi":"10.1034/J.1600-0420.2001.079004431.X","DOIUrl":"https://doi.org/10.1034/J.1600-0420.2001.079004431.X","url":null,"abstract":"","PeriodicalId":7152,"journal":{"name":"Acta ophthalmologica Scandinavica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2001-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91068133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2001-08-01DOI: 10.1034/J.1600-0420.2001.079004417.X
D. Bujarborua
PURPOSE The purpose of this study was to observe the varied types of manifestations in the fundus of patients with idiopathic central serous chorioretinopathy (ICSC) without laser treatment and also to assess the ultimate visual outcome in such cases in a long-term follow-up ranging from 7 to 23 years. METHODS This study is confined to 5 selected cases of ICSC which fairly represent the different types of late stage manifestations of the disease in the fundus. Case records from our hospital, as well as available records of previous treatment elsewhere were reviewed. A complete ophthalmological examination, routine laboratory investigations and fluorescein fundus angiography (FFA) were repeated in each case on the day of final evaluation. RESULTS Pigmentary disturbances in the macular area resembling to some extent age-related macular degeneration (AMD), extensive retinal pigment epithelial (RPE) atrophy and macular haemorrhage have been observed in the fundus of the reviewed cases. CONCLUSIONS ICSC runs an unpredictable course and there are no definitive clinical clues to predict its ultimate outcome. Recurrence of the condition is a possibility for a considerable period of time.
{"title":"Long-term follow-up of idiopathic central serous chorioretinopathy without laser.","authors":"D. Bujarborua","doi":"10.1034/J.1600-0420.2001.079004417.X","DOIUrl":"https://doi.org/10.1034/J.1600-0420.2001.079004417.X","url":null,"abstract":"PURPOSE\u0000The purpose of this study was to observe the varied types of manifestations in the fundus of patients with idiopathic central serous chorioretinopathy (ICSC) without laser treatment and also to assess the ultimate visual outcome in such cases in a long-term follow-up ranging from 7 to 23 years.\u0000\u0000\u0000METHODS\u0000This study is confined to 5 selected cases of ICSC which fairly represent the different types of late stage manifestations of the disease in the fundus. Case records from our hospital, as well as available records of previous treatment elsewhere were reviewed. A complete ophthalmological examination, routine laboratory investigations and fluorescein fundus angiography (FFA) were repeated in each case on the day of final evaluation.\u0000\u0000\u0000RESULTS\u0000Pigmentary disturbances in the macular area resembling to some extent age-related macular degeneration (AMD), extensive retinal pigment epithelial (RPE) atrophy and macular haemorrhage have been observed in the fundus of the reviewed cases.\u0000\u0000\u0000CONCLUSIONS\u0000ICSC runs an unpredictable course and there are no definitive clinical clues to predict its ultimate outcome. Recurrence of the condition is a possibility for a considerable period of time.","PeriodicalId":7152,"journal":{"name":"Acta ophthalmologica Scandinavica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2001-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77976089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2001-06-01DOI: 10.1034/J.1600-0420.2001.790321.X
M. Cristofanilli, N. Pescosolido, G. Risuleo, G. Scarsella
PURPOSE Experimental trials aimed at the research of selective antifibrotic agents are under development for the alternative treatment of glaucoma patients who are usually considered high-risk post-surgical individuals after trabeculectomy. Authors present here an in vitro model system for the treatment of post-trabeculectomy patients. The study is aimed at the evaluation of different drugs in a mouse fibroblast model. METHODS The antifibrotic activity of Cyclosporin A, Interferon 2alpha, 5-Fluorouracyl was investigated on 3T6 cells in culture. Cell viability and proliferation was assessed after drug treatment. Molecular analysis of DNA degradation was evaluated by means of radioactive labeling and gel electrophoresis. RESULTS The three drugs were shown to affect cell proliferation and viability in a differential fashion. However, only Cyclosporin A was able to control cell proliferation, inducing apoptosis. This phenomenon was reduced by supplementation of trolox, a compound known to inhibit programmed cell death. These results strongly suggest that this model system might be useful as a test of pharmacological functionality. CONCLUSION A rapid and efficient model system is described for the assessment of cell viability and proliferation after treatment with agents of potential pharmacological use. Cyclosporin A induces a significant apoptosis. This is important for the negative control of fibrotic degeneration in post-trabeculectomy that is required for successful surgery in glaucoma patients. Therefore, Cyclosporin A might become a clinically interesting drug for the antifibrotic treatment of post-trabeculectomy.
{"title":"A murine cell culture model for post-trabeculectomy anfibrotic treatment: Induction of apoptosis by Cyclosporin.","authors":"M. Cristofanilli, N. Pescosolido, G. Risuleo, G. Scarsella","doi":"10.1034/J.1600-0420.2001.790321.X","DOIUrl":"https://doi.org/10.1034/J.1600-0420.2001.790321.X","url":null,"abstract":"PURPOSE\u0000Experimental trials aimed at the research of selective antifibrotic agents are under development for the alternative treatment of glaucoma patients who are usually considered high-risk post-surgical individuals after trabeculectomy. Authors present here an in vitro model system for the treatment of post-trabeculectomy patients. The study is aimed at the evaluation of different drugs in a mouse fibroblast model.\u0000\u0000\u0000METHODS\u0000The antifibrotic activity of Cyclosporin A, Interferon 2alpha, 5-Fluorouracyl was investigated on 3T6 cells in culture. Cell viability and proliferation was assessed after drug treatment. Molecular analysis of DNA degradation was evaluated by means of radioactive labeling and gel electrophoresis.\u0000\u0000\u0000RESULTS\u0000The three drugs were shown to affect cell proliferation and viability in a differential fashion. However, only Cyclosporin A was able to control cell proliferation, inducing apoptosis. This phenomenon was reduced by supplementation of trolox, a compound known to inhibit programmed cell death. These results strongly suggest that this model system might be useful as a test of pharmacological functionality.\u0000\u0000\u0000CONCLUSION\u0000A rapid and efficient model system is described for the assessment of cell viability and proliferation after treatment with agents of potential pharmacological use. Cyclosporin A induces a significant apoptosis. This is important for the negative control of fibrotic degeneration in post-trabeculectomy that is required for successful surgery in glaucoma patients. Therefore, Cyclosporin A might become a clinically interesting drug for the antifibrotic treatment of post-trabeculectomy.","PeriodicalId":7152,"journal":{"name":"Acta ophthalmologica Scandinavica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2001-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86277345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2001-06-01DOI: 10.1034/J.1600-0420.2001.790319.X
M. Vuori, Tommi Viitanen
PURPOSE To describe a modified surgical technique, a scleral tunnel incision- trabeculectomy (STIT) and evaluate its safety and efficacy in lowering IOP in glaucoma patients. METHODS One hundred and three patients were included in a retrospective, nonrandomized clinical study. Fifty-three patients were operated conventionally and 40 patients underwent STIT. In the modified technique the sides of the scleral flap are opened only half-way to the limbus and the flap is closed with a single releasable "slipknot"-suture. RESULTS The mean IOP on the first postoperative day was 4.5 +/- 6.8 mmHg in the conventional group and 7.4 +/- 7.1 mmHg in the tunnel incision group (p = 0.012). On the second postoperative day the mean IOP was 4.5 +/- 7.3 mmHg and 6.3 +/- 6.5 mmHg in the conventional group and tunnel incision group, respectively (p = 0.065). There was no statistically significant difference in the mean postoperative IOP between the groups at one month and at 6-12 months. Shallow anterior chamber and iridocorneal touch occurred statistically significantly less in the tunnel incision group than in the conventional group. CONCLUSION STIT appears to be equivalent to conventional trabeculectomy (CT) in lowering IOP during the first 6-12 months postoperatively. It is also relatively safe and has fewer early complications related to excessive aqueous outflow than CT.
{"title":"\"Scleral tunnel incision\"-trabeculectomy with one releasable suture.","authors":"M. Vuori, Tommi Viitanen","doi":"10.1034/J.1600-0420.2001.790319.X","DOIUrl":"https://doi.org/10.1034/J.1600-0420.2001.790319.X","url":null,"abstract":"PURPOSE\u0000To describe a modified surgical technique, a scleral tunnel incision- trabeculectomy (STIT) and evaluate its safety and efficacy in lowering IOP in glaucoma patients.\u0000\u0000\u0000METHODS\u0000One hundred and three patients were included in a retrospective, nonrandomized clinical study. Fifty-three patients were operated conventionally and 40 patients underwent STIT. In the modified technique the sides of the scleral flap are opened only half-way to the limbus and the flap is closed with a single releasable \"slipknot\"-suture.\u0000\u0000\u0000RESULTS\u0000The mean IOP on the first postoperative day was 4.5 +/- 6.8 mmHg in the conventional group and 7.4 +/- 7.1 mmHg in the tunnel incision group (p = 0.012). On the second postoperative day the mean IOP was 4.5 +/- 7.3 mmHg and 6.3 +/- 6.5 mmHg in the conventional group and tunnel incision group, respectively (p = 0.065). There was no statistically significant difference in the mean postoperative IOP between the groups at one month and at 6-12 months. Shallow anterior chamber and iridocorneal touch occurred statistically significantly less in the tunnel incision group than in the conventional group.\u0000\u0000\u0000CONCLUSION\u0000STIT appears to be equivalent to conventional trabeculectomy (CT) in lowering IOP during the first 6-12 months postoperatively. It is also relatively safe and has fewer early complications related to excessive aqueous outflow than CT.","PeriodicalId":7152,"journal":{"name":"Acta ophthalmologica Scandinavica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2001-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85617366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2001-06-01DOI: 10.1034/J.1600-0420.2001.790325.X
N. Eide, P. Syrdalen, D. Scheie, Y. Chen, K. Elgjo, E. Kerty, K. Brabrand
PURPOSE To report two cases of invasive uveal melanomas, one of which showed multifocality. METHODS Clinical examination, ultrasonography, colour Doppler analysis, cytological and histopathological evaluations. RESULTS Transvitreal biopsy (case 1) or fine needle aspiration biopsy (FNAB) (case 2) revealed malignant melanomas in both patients. Light microscopy and immunohistochemical examinations substantiated the diagnosis of mixed cell type melanomas. In addition, one patient had a multifocal melanoma with papilloedema and colour Doppler findings suggestive of optic disc involvement. CONCLUSION Transvitreal biopsy for histology or cytology is a reliable procedure to obtain an accurate diagnosis without delay of a lesion adjacent to the optic nerve head. In our two cases the biopsy findings led to enucleation.
{"title":"Uveal melanomas with optic nerve extension: report of two cases diagnosed by transvitreal biopsy, one of them with a multicentric tumour.","authors":"N. Eide, P. Syrdalen, D. Scheie, Y. Chen, K. Elgjo, E. Kerty, K. Brabrand","doi":"10.1034/J.1600-0420.2001.790325.X","DOIUrl":"https://doi.org/10.1034/J.1600-0420.2001.790325.X","url":null,"abstract":"PURPOSE\u0000To report two cases of invasive uveal melanomas, one of which showed multifocality.\u0000\u0000\u0000METHODS\u0000Clinical examination, ultrasonography, colour Doppler analysis, cytological and histopathological evaluations.\u0000\u0000\u0000RESULTS\u0000Transvitreal biopsy (case 1) or fine needle aspiration biopsy (FNAB) (case 2) revealed malignant melanomas in both patients. Light microscopy and immunohistochemical examinations substantiated the diagnosis of mixed cell type melanomas. In addition, one patient had a multifocal melanoma with papilloedema and colour Doppler findings suggestive of optic disc involvement.\u0000\u0000\u0000CONCLUSION\u0000Transvitreal biopsy for histology or cytology is a reliable procedure to obtain an accurate diagnosis without delay of a lesion adjacent to the optic nerve head. In our two cases the biopsy findings led to enucleation.","PeriodicalId":7152,"journal":{"name":"Acta ophthalmologica Scandinavica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2001-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90927450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2001-06-01DOI: 10.1034/J.1600-0420.2001.790317.X
P. Kóthy, P. Vargha, G. Holló
PURPOSE To compare 24-hour diurnal intraocular pressure (IOP) measurements obtained using the Ocuton-S applanation self tonometer and the Goldmann tonometer. METHODS 24-hour diurnal IOP curves were obtained on 14 eyes of 7 trained patients suffering from medically controlled primary open angle glaucoma. IOP was measured every third hour starting at 9 a.m. with a calibrated Goldmann tonometer; one week later, a similar set of measurements was obtained with Ocuton-S self tonometry by the patients. One week later still, ultrasound corneal pachymetry was performed at the same hours. RESULTS Overall IOP (24-hour mean) did not differ significantly between the different measuring techniques (ANOVA, p = 0.74), but the IOP differed in a statistically significant manner around the clock (ANOVA, p = 0.00006). The mean Goldmann tonometric readings were up to 2.8 mmHg lower than the Ocuton-S values during the daytime (9 a.m. to 9 p.m.), however, during the night (12 midnight to 6 a.m.) mean IOP measured with Goldmann tonometry was 2.2 to 3.3 mmHg higher than the corresponding average of the self tonometry readings. There was a statistically significant interaction between the type of tonometry and the time of the measurement (p = 0.0007). Central corneal thickness (CCT) showed a significant change during the 24-hour period (p = 0.000001). CONCLUSION IOP shows a different diurnal curve when measured with the Goldmann tonometer and with the Ocuton-S applanation self tonometer. The instruments' readings might be influenced in different ways by the diurnal changes of the corneal thickness. Since Ocuton-S self tonometry underestimates the IOP in the early morning period, a careful evaluation is necessary when nocturnal and early morning IOP elevation is investigated with this technique.
{"title":"Ocuton-S self tonometry vs. Goldmann tonometry; a diurnal comparison study.","authors":"P. Kóthy, P. Vargha, G. Holló","doi":"10.1034/J.1600-0420.2001.790317.X","DOIUrl":"https://doi.org/10.1034/J.1600-0420.2001.790317.X","url":null,"abstract":"PURPOSE\u0000To compare 24-hour diurnal intraocular pressure (IOP) measurements obtained using the Ocuton-S applanation self tonometer and the Goldmann tonometer.\u0000\u0000\u0000METHODS\u000024-hour diurnal IOP curves were obtained on 14 eyes of 7 trained patients suffering from medically controlled primary open angle glaucoma. IOP was measured every third hour starting at 9 a.m. with a calibrated Goldmann tonometer; one week later, a similar set of measurements was obtained with Ocuton-S self tonometry by the patients. One week later still, ultrasound corneal pachymetry was performed at the same hours.\u0000\u0000\u0000RESULTS\u0000Overall IOP (24-hour mean) did not differ significantly between the different measuring techniques (ANOVA, p = 0.74), but the IOP differed in a statistically significant manner around the clock (ANOVA, p = 0.00006). The mean Goldmann tonometric readings were up to 2.8 mmHg lower than the Ocuton-S values during the daytime (9 a.m. to 9 p.m.), however, during the night (12 midnight to 6 a.m.) mean IOP measured with Goldmann tonometry was 2.2 to 3.3 mmHg higher than the corresponding average of the self tonometry readings. There was a statistically significant interaction between the type of tonometry and the time of the measurement (p = 0.0007). Central corneal thickness (CCT) showed a significant change during the 24-hour period (p = 0.000001).\u0000\u0000\u0000CONCLUSION\u0000IOP shows a different diurnal curve when measured with the Goldmann tonometer and with the Ocuton-S applanation self tonometer. The instruments' readings might be influenced in different ways by the diurnal changes of the corneal thickness. Since Ocuton-S self tonometry underestimates the IOP in the early morning period, a careful evaluation is necessary when nocturnal and early morning IOP elevation is investigated with this technique.","PeriodicalId":7152,"journal":{"name":"Acta ophthalmologica Scandinavica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2001-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90530645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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