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Adult attachment, social anxiety, and problematic social media use: A meta-analysis and meta-analytic structural equation model 成人依恋、社交焦虑和问题社交媒体的使用:元分析和元分析结构方程模型
IF 3.7 2区 医学 Q1 PSYCHOLOGY, CLINICAL Pub Date : 2024-09-10 DOI: 10.1016/j.addbeh.2024.108163
Liangrong Huang, Fang Yang, Wenfeng Wu

The relationship between adult attachment (anxious attachment and avoidant attachment) and problematic social media use is controversial and contradictory. Hence, the present study clarified the relationship between adult attachment dimensions and problematic social media use through meta-analysis. To better explain the relationship, this study also established meta-analytic structural equation modeling to examine the mediating role of social anxiety in the relationship. This study used CMA and R software for data analysis. Forty-five effect sizes were included in the study, including 11,746 individuals. Results showed that anxious attachment was strongly correlated with problematic social media use (r = 0.319, 95 %CI[0.271, 0.366]), whereas avoidant attachment was weakly correlated with problematic social media use (r = 0.091, 95 %CI[0.011,0.170]). Moderating effects showed that the relationship between anxious attachment and problematic social media use was moderated by the measurement instrument. Meta-analytic structural equation modeling showed that anxious attachment had a significant positive effect on PSMU through social anxiety, anxious attachment had a significant positive effect on PSMU through social anxiety. This study clarifies inconsistencies in the existing literature through meta-analysis, providing reliable conclusions and novel perspectives. It assists clinical practitioners in developing tailored treatment programs for practical interventions. It is suggested that treatment for problematic social media use requires attention to individuals with insecure adult attachment and social anxiety. For individuals with high anxious attachment and social anxiety, it is essential to help them manage their social media use effectively and reduce their dependence on it. Concurrently, interventions for attachment avoidant individuals should focus on enhancing their social self-confidence to reduce the influence of social anxiety on their social media use.

成人依恋(焦虑依恋和回避依恋)与问题社交媒体使用之间的关系存在争议和矛盾。因此,本研究通过元分析澄清了成人依恋维度与问题社交媒体使用之间的关系。为了更好地解释两者之间的关系,本研究还建立了元分析结构方程模型来考察社交焦虑在两者关系中的中介作用。本研究使用 CMA 和 R 软件进行数据分析。研究共纳入了 45 个效应大小,包括 11,746 人。结果显示,焦虑型依恋与问题社交媒体的使用呈强相关(r = 0.319, 95 %CI[0.271,0.366]),而回避型依恋与问题社交媒体的使用呈弱相关(r = 0.091, 95 %CI[0.011,0.170])。调节效应表明,焦虑型依恋与问题社交媒体使用之间的关系受到测量工具的调节。元分析结构方程模型显示,焦虑依恋通过社交焦虑对 PSMU 有显著的正向影响,焦虑依恋通过社交焦虑对 PSMU 有显著的正向影响。本研究通过元分析澄清了现有文献中的不一致之处,提供了可靠的结论和新的视角。它有助于临床从业人员制定有针对性的治疗方案,进行实际干预。研究建议,治疗社交媒体使用问题需要关注成人依恋不安全感和社交焦虑的个体。对于高度焦虑依恋和社交焦虑的人,必须帮助他们有效管理社交媒体的使用,减少对社交媒体的依赖。同时,针对依恋回避型个体的干预措施应侧重于增强他们的社交自信,以减少社交焦虑对其社交媒体使用的影响。
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引用次数: 0
Online social support and problematic Internet Use—a meta-analysis 在线社会支持与问题性互联网使用--荟萃分析
IF 3.7 2区 医学 Q1 PSYCHOLOGY, CLINICAL Pub Date : 2024-09-10 DOI: 10.1016/j.addbeh.2024.108160
Yujun Ma , Ziyao Zhou , Chenxi Ye , Mengxin Liu

Introduction

The internet is a crucial platform for individuals to gain social support, enhancing their well-being. However, research indicated that while online social support (OSS) has positive aspects, it also carries potential drawbacks and can lead to problematic Internet use (PIU). This study aims to examine the complex relationship between OSS and PIU.

Methods

Adhering to the PRISMA guidelines, a systematic literature search was performed across five English and three Chinese databases. A total of 1966 articles were initially screened by title, followed by abstract, and finally, full text. And the random-effects model was used to synthesize the included 31 studies.

Results

31 studies were identified, encompassing a total sample of 22,375 participants. Meta-analysis revealed a moderate and significant correlation between OSS and PIU (r = 0.293), and it was significantly moderated by gender and the measurement methods of PIU. Notably, the relationship was more pronounced in studies with a higher proportion of female participants; when PIU was measured by problematic social media use, the relationship with OSS was stronger than studies that measured PIU by general problematic Internet use or problematic mobile phone use.

Conclusion

These findings contribute to a comprehensive understanding of the association between OSS and PIU, and carry implications for identifying and addressing the potential risks associated with social support provision in the digital realm.

导言:互联网是个人获得社会支持、提升幸福感的重要平台。然而,研究表明,尽管在线社会支持(OSS)具有积极的一面,但它也有潜在的弊端,并可能导致有问题的互联网使用(PIU)。本研究旨在探讨在线社交支持与 PIU 之间的复杂关系。方法根据 PRISMA 指南,在五个英文数据库和三个中文数据库中进行了系统的文献检索。共有 1966 篇文章通过标题、摘要和全文进行了初步筛选。结果共发现 31 项研究,样本总数为 22,375 人。元分析表明,OSS 与 PIU 之间存在显著的中度相关性(r = 0.293),并且这种相关性受性别和 PIU 测量方法的显著影响。值得注意的是,这种关系在女性参与者比例较高的研究中更为明显;当以有问题的社交媒体使用来衡量PIU时,OSS与PIU的关系要强于以一般有问题的互联网使用或有问题的手机使用来衡量PIU的研究。
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引用次数: 0
Not always as advertised: Different effects from viewing safer gambling (harm prevention) adverts on gambling urges 并不总是像广告宣传的那样:观看更安全的赌博(预防伤害)广告对赌博冲动的不同影响
IF 3.7 2区 医学 Q1 PSYCHOLOGY, CLINICAL Pub Date : 2024-09-08 DOI: 10.1016/j.addbeh.2024.108161
Philip Newall , Leonardo Weiss-Cohen , Jamie Torrance , Yakov Bart

Public concern around gambling advertising in the UK has been met not by government action but by industry self-regulations, such as a forthcoming voluntary ban on front-of-shirt gambling sponsorship in Premier League soccer. “Safer gambling” (harm prevention) adverts are one recent example, and are TV commercials which inform viewers about gambling-related harm. The present work is the first independent evaluation of safer gambling adverts by both gambling operators and a charity called GambleAware. In an online experiment, we observed the change in participants’ (N = 2,741) Gambling Urge Scale (GUS) scores after viewing either: a conventional financial inducement gambling advert, a gambling operator’s safer gambling advert, an advert from the GambleAware “bet regret” campaign, an advert from the GambleAware “stigma reduction” campaign, or a control advert that was not about gambling. Relative to a neutral control advert, GUS scores increased after viewing a financial inducement or an operator’s safer gambling advert. In comparison to the neutral control condition, GUS score changes were similar after viewing a bet regret advert, but showed a significant decrease after viewing a stigma reduction advert. Those at higher risk of harm reported larger decreases in GUS after watching a bet regret or stigma reduction advert. Overall, this study introduced a novel experimental paradigm for evaluating safer gambling adverts, uncovered a potential downside from gambling operators’ safer gambling adverts, and revealed variation in the potential effectiveness of charity-delivered safer gambling adverts.

在英国,公众对赌博广告的关注并没有得到政府行动的回应,而是得到了行业自律的回应,例如,英超足球联赛即将自愿禁止球衣前的赌博赞助。"更安全的赌博"(预防伤害)广告是最近的一个例子,这些电视广告向观众宣传与赌博有关的伤害。本研究是赌博运营商和一个名为 "提高赌博意识"(GambleAware)的慈善机构对 "加强赌博安全 "广告的首次独立评估。在一项在线实验中,我们观察了参与者(2,741 人)在观看以下任一广告后赌博冲动量表(GUS)得分的变化:传统的经济诱导赌博广告、赌博运营商的更安全赌博广告、GambleAware "打赌后悔 "活动的广告、GambleAware "减少耻辱 "活动的广告或与赌博无关的对照广告。与中性对照广告相比,在观看经济诱导广告或经营者的更安全赌博广告后,GUS 分数有所上升。与中性对照组相比,观看 "后悔下注 "广告后的 GUS 分数变化相似,但观看 "减少污名化 "广告后 GUS 分数显著下降。伤害风险较高的人群在观看投注后悔或减少污名化广告后,其 GUS 下降幅度更大。总之,本研究引入了一种新的实验范式来评估更安全的赌博广告,发现了赌博经营者的更安全赌博广告的潜在弊端,并揭示了慈善机构发布的更安全赌博广告的潜在效果差异。
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引用次数: 0
Racial/ethnic differences in the acute effects of reduced nicotine content cigarettes among adolescents who smoke 吸烟青少年对尼古丁含量降低的香烟急性效应的种族/族裔差异。
IF 3.7 2区 医学 Q1 PSYCHOLOGY, CLINICAL Pub Date : 2024-09-07 DOI: 10.1016/j.addbeh.2024.108147
Mariel S. Bello , Crystal X. Wang , Dale Dagar Maglalang , Robert Rosales , Jennifer W. Tidey , Rachel L. Denlinger-Apte , Alexander W. Sokolovsky , Suzanne M. Colby , Rachel N. Cassidy

Objective

Reducing the nicotine content in cigarettes decreases their addictiveness and abuse liability, including among adolescents. Whether these effects differ by race/ethnicity is unknown. This study is a secondary analysis of previously published data collected between 2014–2017. We examined racial/ethnic differences in the effects of smoking cigarettes with varying nicotine content levels on subjective effects and tobacco withdrawal among adolescents who smoke daily.

Methods

Across two counterbalanced sessions, 50 adolescents recruited from Rhode Island (ages 15–19; 30 % Underrepresented Minorities [URM], 20 % Asians and Pacific Islanders [API]; 50 % Non-Hispanic Whites) self-administered a very low nicotine content (VLNC; 0.4 mg nicotine/g of tobacco) or normal nicotine content control (NNC; 15.8 mg/g) research cigarette following overnight abstinence. Subjective effects were reported post-administration and tobacco withdrawal outcomes were calculated from pre- to post-administration scores. Multilevel linear models tested main and interactive effects between cigarette nicotine content and race/ethnicity on all study outcomes.

Results

Participants reported lower positive subjective effects and reductions in smoking urges after smoking a VLNC cigarette relative to smoking an NNC cigarette (ps < 0.01). A main effect of race/ethnicity emerged, such that API (vs. URM and White) adolescents reported lower positive subjective effects, greater craving reduction, and higher cigarette aversion after smoking, regardless of nicotine content (ps < 0.05). Significant interactions were found between race/ethnicity and nicotine content for cigarette aversion, such that API adolescents rated VLNC (vs. NNC) cigarettes as less aversive than White and URM adolescents did (p = 0.03).

Conclusions

Findings provide evidence that VLNC cigarettes may reduce abuse liability and tobacco withdrawal symptoms for adolescents across racial/ethnic groups and particularly for API youth.

目标:减少香烟中的尼古丁含量可降低香烟的成瘾性和滥用风险,包括对青少年的影响:减少香烟中的尼古丁含量可降低香烟的成瘾性和滥用可能性,包括对青少年的影响。这些效果是否因种族/族裔而异尚属未知。本研究是对之前公布的 2014-2017 年间收集的数据进行的二次分析。我们研究了吸食不同尼古丁含量的卷烟对每天吸烟的青少年的主观影响和烟草戒断的种族/民族差异:50名从罗德岛州招募的青少年(15-19岁;30%为代表性不足的少数族裔[URM],20%为亚洲人和太平洋岛民[API];50%为非西班牙裔白人)在禁烟一夜后,通过两次平衡测试,自行吸食尼古丁含量极低的卷烟(VLNC;0.4毫克尼古丁/克烟草)或尼古丁含量正常的对照卷烟(NNC;15.8毫克/克)。给药后报告主观效果,并根据给药前和给药后的评分计算烟草戒断结果。多层次线性模型检验了卷烟尼古丁含量和种族/民族对所有研究结果的主要影响和交互影响:结果:与吸食 NNC 卷烟相比,吸食 VLNC 卷烟后,参与者报告的积极主观效应和吸烟冲动减少的程度较低(ps 结论:研究结果提供了 VLNC 卷烟的证据:研究结果证明,VLNC卷烟可减少不同种族/族裔青少年的滥用责任和戒烟症状,特别是对亚太裔青少年而言。
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引用次数: 0
Establishing a standard measure of blunt and cigar use for U.S. national surveys 为美国全国调查建立钝器和雪茄使用的标准衡量标准
IF 3.7 2区 医学 Q1 PSYCHOLOGY, CLINICAL Pub Date : 2024-09-06 DOI: 10.1016/j.addbeh.2024.108156
David S. Timberlake

Background

Researchers have drawn attention to the need for modifying survey questions on cigars for distinguishing use intended for tobacco versus cannabis (i.e. blunt) consumption. Yet, most surveys do not distinguish persons who only smoke blunts (POSB) from persons who smoke blunts and unmodified cigars/cigarillos (PSBC). This study was intended to evaluate existing measures in U.S. national surveys for establishing a standard for the field.

Methods

Two of six leading U.S national surveys, the NSDUH and PATH, measured dual use of blunts and cigars. The analytical sample of this study included adult participants of the 2017 NSDUH (n = 2493) and Wave 4 PATH (n = 3175) who smoked a cigar or blunt in the past month and reported cigar brand usually or last smoked; the latter was used as a validation measure.

Results

Odds of using Swisher Sweets and other brands (vs. Black & Mild) increased with more frequent blunt use relative to persons who only smoked unmodified cigars/cigarillos (POSC). Further, regression coefficients for the three subgroups of PSBC differed significantly, highlighting the utility of an ordinal versus aggregated measure. Estimates of the former were diminished in magnitude upon expanding the sample to persons who smoked any cigar product.

Conclusions

Validation of the ordinal measure of blunt-cigarillo use in PATH supports the measure’s implementation as a standard for U.S. national surveys. Implementation of the measure in other surveys (e.g., NSDUH) would provide a more consistent and accurate assessment of blunt and cigar use for monitoring health risks.

背景研究人员已提请注意有必要修改有关雪茄的调查问题,以区分雪茄是用于吸食烟草还是用于吸食大麻(即钝烟)。然而,大多数调查并不区分只吸钝烟者(POSB)和吸钝烟及未改装雪茄/雪茄烟者(PSBC)。本研究旨在评估美国国家调查中的现有测量方法,以便为该领域建立一个标准。方法美国六项主要国家调查中的两项,即 NSDUH 和 PATH,测量了短烟头和雪茄的双重使用情况。本研究的分析样本包括 2017 年 NSDUH(n = 2493)和第 4 波 PATH(n = 3175)的成年参与者,他们在过去一个月内吸食过雪茄或钝烟,并报告了通常或最后一次吸食的雪茄品牌;后者被用作验证措施。结果相对于只吸食未经改装的雪茄/雪茄烟(POSC)的人而言,使用 Swisher Sweets 和其他品牌(与 Black & Mild 相比)钝烟的频率越高,使用钝烟的比率就越高。此外,PSBC 三个亚组的回归系数也有显著差异,这突出表明了序数衡量与综合衡量的效用。在将样本扩大到吸食任何雪茄产品的人群后,前者的估计值在幅度上有所减小。在其他调查(如美国国家统计与人口普查)中采用该指标将为监测健康风险提供更一致、更准确的钝烟和雪茄使用情况评估。
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引用次数: 0
How are illness representations of gambling disorder associated with gambling behaviors? A latent profile analysis 赌博障碍的疾病表征与赌博行为有何关联?潜在特征分析
IF 3.7 2区 医学 Q1 PSYCHOLOGY, CLINICAL Pub Date : 2024-09-01 DOI: 10.1016/j.addbeh.2024.108149
Hong Mian Yang , Joseph T.F. Lau , Lawrence Hoc Nang Fong , Shu Fai Cheung , Anise M.S. Wu

Gambling disorder (GD) is a behavioral addiction that causes serious harm to individuals’ mental health and social functioning. This study aimed to explore whether gamblers’ illness representations (IR) for GD are related to disordered and/or controlled patterns of gambling under the framework of commonsense model of self-regulation (CSM). Based on CSM, different facets of IR do not exist in isolation but together form a total illness schema; we hence used a person-centered analysis method, latent profile analysis (LPA), to classify gamblers by their overall IR for GD (including consequences, personal and treatment control, timeline cyclical, emotional representations, and coherence) into groups and then tested whether these groups differed in GD symptoms, controlled gambling behaviors, and help-seeking intention. An anonymous online survey was conducted on a social media platform, and valid responses from 589 past-year adult gamblers were collected. LPA results supported a four-profile model, revealing four profiles of GD representations: the weak-perception profile, average profile, tensed-up profile, and rational profile. Significant differences were found in all outcome variables in these four profile groups. In particular, the rational group exhibited the lowest levels of GD symptoms and impaired behavioral control, the highest levels of responsible and controlled gambling, and the highest levels of help-seeking intention, whereas the weak-perception group reported the lowest levels of responsible and controlled gambling behaviors. The findings provide empirical support for the application of CSM to addictive behaviors, as well as preliminary evidence for the potential use of CSM-based interventions for GD prevention.

赌博障碍(GD)是一种行为成瘾,对个人的心理健康和社会功能造成严重危害。本研究旨在探讨在常识性自我调节模型(CSM)的框架下,赌博者对赌博障碍的疾病表征(IR)是否与无序和/或受控的赌博模式有关。因此,我们采用以人为中心的分析方法--潜在轮廓分析(LPA),根据赌徒对广东赌博的总体疾病表征(包括后果、个人和治疗控制、时间轴周期性、情绪表征和连贯性)将赌徒分为不同组别,然后检验这些组别在广东赌博症状、控制赌博行为和求助意向方面是否存在差异。在社交媒体平台上进行了匿名在线调查,收集到了 589 名过去一年的成年赌徒的有效回复。LPA结果支持四种表征模型,揭示了四种GD表征:弱感知表征、平均表征、紧张表征和理性表征。在这四个特征组中,所有结果变量都存在显著差异。其中,理性组的广东话症状和行为控制能力受损程度最低,负责任和受控的赌博程度最高,求助意向程度最高,而弱感知组的负责任和受控的赌博行为程度最低。研究结果为 CSM 在成瘾行为中的应用提供了经验支持,也为基于 CSM 的干预措施在预防广东赌博中的潜在应用提供了初步证据。
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引用次数: 0
The many forms of cannabis use: Prevalence and correlates of routes of administration among nationally representative samples of U.S. adult and adolescent cannabis users 使用大麻的多种形式:具有全国代表性的美国成人和青少年大麻使用者样本中给药途径的流行率和相关性
IF 3.7 2区 医学 Q1 PSYCHOLOGY, CLINICAL Pub Date : 2024-09-01 DOI: 10.1016/j.addbeh.2024.108146
Wanda E. Leal, Kelsi Moscrop-Blake

Background

Cannabis legalization has made cannabis accessible via dispensaries which sell a wide variety of cannabis products. Importantly, the various routes of administration are associated with differing consequences. As such, it’s crucial to understand the prevalence and correlates of different cannabis products. Unfortunately, research has yet to examine the prevalence of certain forms of cannabis use, and little is known about the prevalence of using multiple forms of cannabis, and whether individual-level factors are associated with using different forms of cannabis.

Methods

The current study uses data from the 2022 National Survey on Drug Use and Health (NSDUH) to examine the prevalence and correlates of eight different types of cannabis use (smoking, vaping, eating/drinking, dabbing, drops/lozenges, topical, pills, and other), as well as a cannabis variety scale, on samples of adult and adolescent cannabis users.

Results

The results suggest that certain routes of administration are more prevalent than others and that these patterns are fairly consistent between adults and adolescents. Similarly, for both adults and adolescents, the majority of users used more than one cannabis product. Lastly, several individual-level factors are associated with the various forms of cannabis use and many of these associations vary by the route of administration examined.

Conclusions

The results of the current study demonstrate that there are differences among cannabis users. If we can develop an understanding of who uses the various forms of cannabis, we could identify the users of the more dangerous forms and provide these individuals with more resources.

背景大麻合法化使人们可以通过药房获得大麻,药房出售各种各样的大麻产品。重要的是,不同的给药途径会产生不同的后果。因此,了解不同大麻产品的流行率和相关性至关重要。遗憾的是,研究尚未对某些形式的大麻使用流行率进行调查,对使用多种形式大麻的流行率以及个人层面的因素是否与使用不同形式的大麻相关也知之甚少。方法本研究使用 2022 年全国药物使用和健康状况调查(NSDUH)的数据,对成人和青少年大麻使用者样本中八种不同类型的大麻使用(吸烟、吸食、吃/喝、点吸、滴剂/锭剂、外用药、药片和其他)的流行率和相关因素以及大麻种类量表进行了研究。结果研究结果表明,某些给药途径比其他途径更普遍,而且这些模式在成人和青少年之间相当一致。同样,无论是成年人还是青少年,大多数使用者都使用一种以上的大麻产品。最后,一些个人层面的因素与各种形式的大麻使用有关,其中许多关联因所研究的给药途径而异。如果我们能够了解哪些人使用各种形式的大麻,就可以识别出哪些人使用危险性更大的大麻,并为这些人提供更多资源。
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引用次数: 0
Physical activity as a moderator of the association between alcohol consumption and hangovers 体育活动是调节饮酒与宿醉之间关系的因素
IF 3.7 2区 医学 Q1 PSYCHOLOGY, CLINICAL Pub Date : 2024-08-30 DOI: 10.1016/j.addbeh.2024.108145
Clayton Neighbors , J. Leigh Leasure , Faith Shank , Paige Ryan , Laian Z. Najjar , Cody Sze , Craig E. Henderson , Chelsie M. Young

Frequently mentioned anecdotally, hangovers are under-investigated within the scientific study of alcohol, as is the role of physical activity (PA) on hangovers. The well-established positive association between PA and AC (AC) suggests that PA may buffer negative physiological consequences of AC, including hangovers. The present study was therefore conducted in order to determine whether PA influences hangovers. Undergraduates (N=1676) from two large universities in the United States who experienced at least one hangover in the past three months and who engaged in at least 30 min of moderate PA per week were recruited to participate. Participants completed online questionnaires about their AC, PA, and frequency and severity of hangover symptoms. Both between- and within-person associations between AC and hangover were examined, factoring in the potential moderating effects of both moderate and vigorous PA. Small effects were observed for correlations between PA and outcomes assessing AC and hangovers (rs ranged from 0.09 to 0.15). Results also revealed that individuals who consumed more alcohol per month experienced hangovers more frequently and had more severe symptoms. These associations were attenuated among individuals who spent more hours engaging in vigorous but not moderate PA. The current study is the first to show PA influences the experience of hangovers, and we posit this may be a mechanism underlying the positive relationship between PA and AC. Our findings advance the growing literature on alcohol use and PA and may contribute to the development of interventions for alcohol-related problems and alcohol use disorders.

宿醉经常被轶事提及,但在酒精的科学研究中,对宿醉的研究不足,而体育锻炼(PA)对宿醉的作用也是如此。体力活动与酒精中毒(AC)之间的正相关关系已得到证实,这表明体力活动可以缓冲酒精中毒的负面生理后果,包括宿醉。因此,本研究旨在确定 PA 是否会影响宿醉。本研究招募了美国两所大型大学的本科生(1676 人)参加,他们在过去三个月中至少有过一次宿醉经历,并且每周至少进行 30 分钟的适度 PA。参与者填写了有关其空调、PA、宿醉症状的频率和严重程度的在线问卷。在考虑了适度和剧烈运动的潜在调节作用后,研究人员对咖啡因与宿醉之间的人际关系和人内关系进行了研究。观察发现,PA 与 AC 和宿醉评估结果之间的相关性影响较小(rs 在 0.09 到 0.15 之间)。结果还显示,每月饮酒量越大的人宿醉的频率越高,症状也越严重。在进行剧烈而非适度体育锻炼时间较长的人群中,这些关联有所减弱。目前的研究首次表明,体育锻炼会影响宿醉的体验,我们认为这可能是体育锻炼和酒精中毒之间正相关关系的一种机制。我们的研究结果推动了有关酒精使用和 PA 的文献的发展,并可能有助于开发针对酒精相关问题和酒精使用障碍的干预措施。
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引用次数: 0
Mental health related adverse events of cytisine and varenicline in smokers with and without mental health disorders: Secondary analysis of a randomized controlled trial 有精神障碍和无精神障碍吸烟者服用胞二磷胆碱和伐尼克兰后出现的与精神健康相关的不良事件:随机对照试验的二次分析
IF 3.7 2区 医学 Q1 PSYCHOLOGY, CLINICAL Pub Date : 2024-08-29 DOI: 10.1016/j.addbeh.2024.108148
Saki Rubaiya Talukder , Julia Lappin , Veronica Clare Boland , Natasha Weaver , Hayden McRobbie , Ryan James Courtney

Introduction

Little is known about the adverse events (AEs) of cytisine versus varenicline among individuals with mental health disorders (MHDs), highlighting the necessity for further exploration to inform clinical practice. This secondary analysis of clinical trial data aimed to investigate the effect of varenicline vs. cytisine regarding mental-health-related AEs (MH-related AEs) on smokers with and without MHDs.

Methods

Australian daily smokers interested in quitting were randomised to varenicline (84 days) or cytisine (25 days) and categorised by self-reported MHD diagnosis or treatment in the past year (MHD or non-MHD groups). Treatment adherence was assessed by self-reported number of doses taken during the active treatment phase via two check-in calls (at one month), while AEs were evaluated through four phone interviews: two check-in calls (one month) and follow-up calls at four and seven months. Logistic regression analysis compared MH-related AEs between groups, including only participants taking at least one dose.

Results

Of 1452 smokers 246 reported MHDs, 725 received cytisine and 727 received varenicline. Median number of doses taken was comparable between MHD (34 cytisine and 12 varenicline) and non-MHD (33 cytisine and 13 varenicline) groups. MH-related AEs were: 14.1 % (n = 30) in MHD (12.5 % in cytisine and 15.4 % in varenicline), and 11.8 % (n = 126) in non-MHD group (10.9 % in cytisine and 13.7 % in varenicline). No significant difference in MH-related AE occurrence was identified between medication groups (aOR=0.96, 95 % CI 0.4 to 2.2, p-value = 0.94).

Conclusion

Comparable MH-related AEs were observed between smokers with and without MHDs, suggesting that cytisine, like varenicline, may be well-tolerated by those with MHDs. However, larger clinical trials focused on MH-related AEs are needed for more conclusive evidence.

导言:人们对胞二磷胆碱与伐尼克兰在精神疾病(MHD)患者中的不良事件(AEs)知之甚少,因此有必要进行进一步研究,为临床实践提供依据。方法将有意戒烟的澳大利亚日常吸烟者随机分配到伐伦克林(84天)或胞二磷胆碱(25天)治疗方案中,并根据其自我报告的过去一年中的MHD诊断或治疗情况进行分类(MHD组或非MHD组)。治疗依从性通过两次报到电话(一个月一次)对积极治疗阶段的自我报告服药次数进行评估,而不良反应则通过四次电话访谈进行评估:两次报到电话(一个月一次)以及四月和七个月的随访电话。逻辑回归分析比较了各组之间与 MH 相关的 AEs,其中只包括至少服用一次药物的参与者。MHD组(34例胞二辛和12例伐尼克兰)和非MHD组(33例胞二辛和13例伐尼克兰)的服药次数中位数相当。与精神健康相关的不良反应有MHD组为14.1%(n = 30)(胞二磷胆碱为12.5%,伐尼克兰为15.4%),非MHD组为11.8%(n = 126)(胞二磷胆碱为10.9%,伐尼克兰为13.7%)。结论在有和没有MHD的吸烟者中观察到了可比的MH相关AE,这表明胞二辛和伐伦克林一样,MHD患者也能很好地耐受。不过,要想获得更多确凿证据,还需要进行更大规模的临床试验,重点研究与MH相关的AEs。
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引用次数: 0
The acute effect of mindfulness-based regulation on neural indices of cue-induced craving in smokers 正念调节对吸烟者线索诱发渴求神经指数的急性影响
IF 3.7 2区 医学 Q1 PSYCHOLOGY, CLINICAL Pub Date : 2024-08-21 DOI: 10.1016/j.addbeh.2024.108134
Ming Zheng , Tiantian Hong , Hui Zhou , Eric L. Garland , Yuzheng Hu

Mindfulness has garnered attention for its potential in alleviating cigarette cravings; however, the neural mechanisms underlying its efficacy remain inadequately understood. This study (N=46, all men) aims to examine the impact of a mindfulness strategy on regulating cue-induced craving and associated brain activity. Twenty-three smokers, consuming over 10 cigarettes daily for at least 2 years, were compared to twenty-three non-smokers. During a regulation of craving task, participants were asked to practice mindfulness during smoking cue-exposure or passively view smoking cues while fMRI scans were completed. A 2 (condition: mindfulness-cigarette and look-cigarette) × 2 (phase: early, late of whole smoking cue-exposure period) repeated measures ANOVA showed a significant interaction of the craving scores between condition and phase, indicating that the mindfulness strategy dampened late-phase craving. Additionally, within the smoker group, the fMRI analyses revealed a significant main effect of mindfulness condition and its interaction with time in several brain networks involving reward, emotion, and interoception. Specifically, the bilateral insula, ventral striatum, and amygdala showed lower activation in the mindfulness condition, whereas the activation of right orbitofrontal cortex mirrored the strategy-time interaction effect of the craving change. This study illuminates the dynamic interplay between mindfulness, smoking cue-induced craving, and neural activity, offering insights into how mindfulness may effectively regulate cigarette cravings.

正念在缓解香烟渴求方面的潜力备受关注;然而,人们对正念功效的神经机制仍缺乏足够的了解。本研究(N=46,均为男性)旨在考察正念策略对调节线索诱发的渴求和相关大脑活动的影响。23名吸烟者与23名非吸烟者进行了比较,前者每天吸烟10支以上,至少已吸食2年。在一项调节渴求的任务中,参与者被要求在吸烟线索暴露时练习正念,或在完成fMRI扫描时被动地查看吸烟线索。2(条件:正念-卷烟和观察-卷烟)×2(阶段:整个吸烟线索暴露期的早期、晚期)重复测量方差分析显示,条件和阶段之间的渴求得分存在显著交互作用,表明正念策略抑制了晚期阶段的渴求。此外,在吸烟者组中,fMRI 分析显示,在涉及奖赏、情绪和知觉的几个大脑网络中,正念条件及其与时间的交互作用具有显著的主效应。具体来说,在正念状态下,双侧脑岛、腹侧纹状体和杏仁核的激活较低,而右侧眶额皮层的激活反映了渴求变化的策略-时间交互效应。这项研究揭示了正念、吸烟线索诱发的渴求和神经活动之间的动态相互作用,为正念如何有效调节香烟渴求提供了启示。
{"title":"The acute effect of mindfulness-based regulation on neural indices of cue-induced craving in smokers","authors":"Ming Zheng ,&nbsp;Tiantian Hong ,&nbsp;Hui Zhou ,&nbsp;Eric L. Garland ,&nbsp;Yuzheng Hu","doi":"10.1016/j.addbeh.2024.108134","DOIUrl":"10.1016/j.addbeh.2024.108134","url":null,"abstract":"<div><p>Mindfulness has garnered attention for its potential in alleviating cigarette cravings; however, the neural mechanisms underlying its efficacy remain inadequately understood. This study (<em>N</em>=46, all men) aims to examine the impact of a mindfulness strategy on regulating cue-induced craving and associated brain activity. Twenty-three smokers, consuming over 10 cigarettes daily for at least 2 years, were compared to twenty-three non-smokers. During a regulation of craving task, participants were asked to practice mindfulness during smoking cue-exposure or passively view smoking cues while fMRI scans were completed. A 2 (condition: mindfulness-cigarette and look-cigarette) <span><math><mrow><mo>×</mo></mrow></math></span> 2 (phase: early, late of whole smoking cue-exposure period) repeated measures ANOVA showed a significant interaction of the craving scores between condition and phase, indicating that the mindfulness strategy dampened late-phase craving. Additionally, within the smoker group, the fMRI analyses revealed a significant main effect of mindfulness condition and its interaction with time in several brain networks involving reward, emotion, and interoception. Specifically, the bilateral insula, ventral striatum, and amygdala showed lower activation in the mindfulness condition, whereas the activation of right orbitofrontal cortex mirrored the strategy-time interaction effect of the craving change. This study illuminates the dynamic interplay between mindfulness, smoking cue-induced craving, and neural activity, offering insights into how mindfulness may effectively regulate cigarette cravings.</p></div>","PeriodicalId":7155,"journal":{"name":"Addictive behaviors","volume":"159 ","pages":"Article 108134"},"PeriodicalIF":3.7,"publicationDate":"2024-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142045047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Addictive behaviors
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