Addictive behaviors最新文献_第2页

A novel smoking cessation behavior based on quit attempts may identify new genes associated with long-term abstinence 基于戒烟尝试的新型戒烟行为可确定与长期戒烟相关的新基因

IF 3.7 2区医学 Q1 PSYCHOLOGY, CLINICAL

Addictive behaviors

Pub Date : 2024-10-28 DOI: 10.1016/j.addbeh.2024.108192

Adriana Lori, Alpa V. Patel, J. Lee Westmaas, W. Ryan Diver

Background

Smoking cessation at any age has been shown to improve quality of life, decrease illness, and reduce mortality. About half of smokers attempt to quit each year, but only ∼ 7 % maintain long-term abstinence unaided. Few genetic factors have been consistently associated with smoking cessation, possibly due to poor phenotype definition.

Methods

We performed a genome-wide association study (GWAS) with an alternative phenotype based on the difficulty of quitting smoking (DQS) in the Cancer Prevention Study-3 cohort. Difficult quitters were defined as having made at least ten quit attempts, whether successful or not, and easy quitters as having quit after only one attempt. Only individuals of European ancestry were selected for the study. Among 10,004 smokers (5,071 difficult quitters, 4,933 easy quitters), we assessed the genetic heritability of DQS and evaluated associations between DQS and each genome-wide variant using logistic regression while adjusting for confounders, including smoking intensity (cigarettes per day).

Results

The genetic heritability of the DQS phenotype was 13 %, comparable to, or higher than, the reported heritability of other smoking behaviors (e.g., smoking intensity, cessation). Although no variants were genome-wide significant, several genes were identified at a subthreshold level (p < 10^-4). A variant in MEGF9 (rs149760032), a transmembrane protein largely expressed in the central nervous system, showed the strongest association with DQS (OR = 0.60, p = 1.3x10^-7). Additional variants associated with DQS independently by smoking intensity were also detected in GLRA3 (rs73006492, OR = 0.77, p = 5.6x10^-7) and FOCAD (rs112251973, OR = 1.96, p = 1.8x10^-6) and are plausibly related to smoking cessation through pathways in the brain and respiratory system.

Conclusions

The use of an alternative cessation phenotype based on difficulty quitting smoking facilitated the identification of new pathways that could lead to unique smoking treatments.

背景任何年龄段的戒烟都能提高生活质量、减少疾病和降低死亡率。每年大约有一半的吸烟者试图戒烟，但只有 7% 的人能够在没有帮助的情况下保持长期戒烟。我们在癌症预防研究-3队列中进行了一项全基因组关联研究（GWAS），根据戒烟难度（DQS）确定了另一种表型。困难戒烟者被定义为至少尝试过十次戒烟（无论成功与否），而容易戒烟者被定义为只尝试过一次戒烟。研究只选取了欧洲血统的人。在 10,004 名吸烟者（5,071 名难戒者，4,933 名易戒者）中，我们评估了 DQS 的遗传率，并使用逻辑回归评估了 DQS 与每个全基因组变异之间的关联，同时调整了混杂因素，包括吸烟强度（每天吸烟支数）。虽然没有变异在全基因组中具有显著性，但有几个基因的变异达到了亚阈值水平（p < 10-4）。MEGF9（rs149760032）是一种主要在中枢神经系统中表达的跨膜蛋白，它的一个变异与DQS的关系最为密切（OR = 0.60，p = 1.3x10-7）。在 GLRA3（rs73006492，OR = 0.77，p = 5.6x10-7）和 FOCAD（rs112251973，OR = 1.96，p = 1.8x10-6）中也检测到了与 DQS 相关的其他变异，这些变异与吸烟强度无关，可能通过大脑和呼吸系统的途径与戒烟有关。

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引用次数: 0

Hippocrates in addiction and the need for transdiagnostic phenotypes to address evidence-based interventions 成瘾中的希波克拉底以及需要跨诊断表型来解决循证干预问题。

IF 3.7 2区医学 Q1 PSYCHOLOGY, CLINICAL

Addictive behaviors

Pub Date : 2024-10-18 DOI: 10.1016/j.addbeh.2024.108190

Mauro Pettorruso, Francesco Di Carlo, Giorgio Di Lorenzo, Giovanni Martinotti

引用次数: 0

The mediating role of intentional self-regulation in the constructive and pathological compensation processes of problematic social networking use 有意自我调节在问题社交网络使用的建设性和病态补偿过程中的中介作用。

IF 3.7 2区医学 Q1 PSYCHOLOGY, CLINICAL

Addictive behaviors

Pub Date : 2024-10-09 DOI: 10.1016/j.addbeh.2024.108188

Qianqian Li , Tianlong Chen , Shujing Zhang , Chuanhua Gu , Zongkui Zhou

Perceived social isolation is a key predictor of college students’ problematic social networking site use (PSNSU). According to the Fear-Driven/Compensation-Seeking Hypothesis, reducing the fear of social isolation and compensating for social deficits serve as negative reinforcement motivations for SNS use, which may potentially result in PSNSU. This study investigated the association between perceived social isolation and PSNSU through the mediating roles of intentional self-regulation and parasocial relationships from a compensatory perspective. Additionally, gender differences in the mediating model were examined. Findings from an online survey of 893 college students in China revealed a positive relationship between perceived social isolation and PSNSU. The serial mediation model showed that intentional self-regulation and parasocial relationships both had positive individual mediating effects, as well as a negative serial mediating effect. Moreover, these mediating effects were only significant among women. The findings suggest that in the association between perceived social isolation and PSNSU, the mediating role of intentional self-regulation forms a constructive compensatory process, while its serial mediating role through parasocial relationships forms a pathological compensatory process. Interventions for PSNSU should take the mediating role of intentional self-regulation in constructive compensation process and the gender difference into consideration.

社会隔离感是大学生使用问题社交网站（PSNSU）的一个重要预测因素。根据 "恐惧驱动/补偿寻求假说"（Fear-Driven/Compensation-Seeking Hypothesis），减少对社交孤立的恐惧和补偿社交缺陷是使用社交网站的负强化动机，这有可能导致 PSNSU。本研究从补偿的角度，通过有意的自我调节和寄生社会关系的中介作用，研究了感知到的社交孤立与 PSNSU 之间的关联。此外，还考察了中介模型中的性别差异。对 893 名中国大学生的在线调查结果显示，感知到的社会隔离与 PSNSU 之间存在正相关。序列中介模型显示，有意的自我调节和寄生社会关系都具有积极的个体中介效应，以及消极的序列中介效应。而且，这些中介效应只对女性有显著影响。研究结果表明，在感知到的社会隔离与 PSNSU 之间的关联中，有意自我调节的中介作用形成了一个建设性的补偿过程，而其通过寄生社会关系的序列中介作用则形成了一个病态的补偿过程。针对 PSNSU 的干预措施应考虑到有意自我调节在建设性补偿过程中的中介作用和性别差异。

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引用次数: 0

Alcohol and cannabis co-use: Probing subjective response in eliciting cross-substance craving 酒精和大麻的共同使用：在诱发交叉药物渴求时探究主观反应

IF 3.7 2区医学 Q1 PSYCHOLOGY, CLINICAL

Addictive behaviors

Pub Date : 2024-10-09 DOI: 10.1016/j.addbeh.2024.108189

Kaitlin R. McManus , Alexandra Venegas , Ziva D. Cooper , Lara A. Ray

The co-use of alcohol and cannabis is rising in prevalence, yet the mechanisms driving individuals to co-use are not well understood. Subjective response to alcohol or cannabis may predict the desire to use either substance. However, which specific facets of subjective response predict cross-substance craving remains unclear. The present study investigated whether acute administration of alcohol or cannabis facilitates cue-induced craving for the other substance, with an emphasis on the underlying subjective response mechanisms contributing to co-use. This is a secondary analysis of a behavioral pharmacology study that combined alcohol/cannabis administration with a cross-substance cue-reactivity paradigm in individuals who were heavy alcohol and heavy cannabis co-users. Over two sessions, twenty-nine individuals (17M/12F) self-administered alcohol or cannabis (in a crossover design), and then completed a cue-reactivity exercise with the other substance. Analyses tested how changes in subjective response variables following substance administration predicted cross-substance cue-induced craving. Following alcohol administration, greater subjective ratings of positive mood predicted significantly greater cue-induced cannabis craving (β = 1.14, SE = 0.41, t = 2.80, p = 0.010). Following cannabis administration, lower subjective effects ratings of positive mood/arousal predicted significantly greater cue-induced alcohol craving (β = −1.08, SE = 0.38, t = −2.85, p = 0.009; β = −2.38, SE = 1.13, t = −2.10, p = 0.047). This study identified subject response mechanisms contributing to cross-substance cue induced craving. These mechanisms include increases in positive mood following alcohol use and decreases in positive mood and arousal, akin to increases in relaxation, following cannabis use.

同时使用酒精和大麻的现象越来越普遍，但人们对驱使人们同时使用酒精和大麻的机制却不甚了解。对酒精或大麻的主观反应可能预示着使用其中一种物质的欲望。然而，主观反应的哪些具体方面可以预测交叉药物渴求仍不清楚。本研究调查了急性服用酒精或大麻是否会促进由线索诱发的对另一种物质的渴求，重点是导致共同使用的潜在主观反应机制。本研究是对一项行为药理学研究的二次分析，该研究将酒精/大麻给药与交叉物质线索反应范式相结合，研究对象是大量同时使用酒精和大麻的人。在两个疗程中，29 人（17M/12F）自我注射了酒精或大麻（交叉设计），然后完成了另一种物质的线索反应练习。分析检验了服用药物后主观反应变量的变化如何预测交叉药物线索诱发的渴求。饮酒后，积极情绪的主观评价越高，提示诱发的大麻渴求就越高（β = 1.14，SE = 0.41，t = 2.80，p = 0.010）。吸食大麻后，积极情绪/唤醒的主观效果评分越低，提示诱发的酒精渴求程度越高（β = -1.08, SE = 0.38, t = -2.85, p = 0.009; β = -2.38, SE = 1.13, t = -2.10, p = 0.047）。这项研究确定了导致跨物质线索诱发渴求的主体反应机制。这些机制包括使用酒精后积极情绪的增加，以及使用大麻后积极情绪和唤醒的减少，类似于放松的增加。

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引用次数: 0

Irritable Bowel Syndrome (IBS) and Smoking: An Evaluation of IBS symptom severity and anxiety sensitivity among adults in the United States 肠易激综合征 (IBS) 与吸烟：对美国成年人肠易激综合征症状严重程度和焦虑敏感性的评估。

IF 3.7 2区医学 Q1 PSYCHOLOGY, CLINICAL

Addictive behaviors

Pub Date : 2024-10-02 DOI: 10.1016/j.addbeh.2024.108187

Michael J. Zvolensky , Tanya Smit , Ileana Dragoi , Rishitaa Tamminana , Jafar Bakhshaie , Joseph W. Ditre , Brooke Y. Redmond , Jeffrey Lackner

Introduction

Irritable bowel syndrome (IBS) is a prevalent disorder of gut-brain function associated with psychological distress as well as work and quality of life impairment. Smoking has been linked to gastrointestinal dysfunction, however, research focused on the prevalence of IBS and smoking is limited. Previous research has shown that anxiety sensitivity is linked to increased risk of aversive bodily experiences and subsequent coping-oriented regulation efforts. Higher anxiety sensitivity has also been associated with processes linked to tobacco cigarette smoking lapse and relapse. There is a need to clarify the explanatory roles of anxiety sensitivity in the context of more severe IBS symptoms among persons with IBS who are current smokers.

Method

The present investigation evaluated the main and interactive effects of IBS symptom severity and anxiety sensitivity in relation to processes related to the maintenance and relapse of tobacco smoking among adults with IBS. The sample consisted of 263 (52.1 % female; M_age = 44.13 years, SD = 12.71) adults who met criteria for IBS and smoke at least 5 cigarettes per day.

Results

Hierarchical regression results indicated that both anxiety sensitivity and IBS symptom severity independently predicted greater perceived barriers to smoking cessation, severity of problems experienced during quitting, and negative reinforcement smoking expectancies. A statistically significant interaction further indicated that IBS symptom severity was more strongly associated with negative reinforcement smoking expectancies among participants with higher, relative to lower, anxiety sensitivity.

Conclusions

This study is the first to show that both IBS symptom severity and anxiety sensitivity are related to greater perceived barriers to smoking cessation, previous difficulty quitting, and negative reinforcement expectancies among adults with IBS. There is a continued need to further scientific understanding of interrelations between anxiety sensitivity, IBS symptom severity, and smoking cessation-related beliefs and processes to identify novel approaches that can best support quitting among this understudied population.

简介肠易激综合征（IBS）是一种普遍存在的肠道-大脑功能紊乱，与心理困扰以及工作和生活质量受损有关。吸烟与肠胃功能紊乱有关，但有关肠易激综合征和吸烟的研究却很有限。以往的研究表明，焦虑敏感性与厌恶性身体体验的风险增加以及随后以应对为导向的调节努力有关。较高的焦虑敏感性也与吸烟失误和复吸过程有关。有必要澄清焦虑敏感性在当前吸烟的肠易激综合征患者出现更严重的肠易激综合征症状时的解释作用：本调查评估了肠易激综合征症状严重程度和焦虑敏感性对肠易激综合征成人吸烟维持和复吸过程的主要影响和交互影响。样本包括263名（52.1%为女性；年龄=44.13岁，SD=12.71）符合IBS标准且每天至少吸烟5支的成年人：分层回归结果表明，焦虑敏感性和肠易激综合征症状严重程度可独立预测戒烟障碍、戒烟过程中遇到的问题严重程度和负强化吸烟预期。一项具有统计学意义的交互作用进一步表明，相对于较低的焦虑敏感度，焦虑敏感度较高的参与者的肠易激综合征症状严重程度与负强化吸烟预期有更强的相关性：本研究首次表明，肠易激综合征症状严重程度和焦虑敏感性与肠易激综合征成人戒烟障碍感知、既往戒烟困难和负强化预期有关。对于焦虑敏感性、肠易激综合征症状严重程度以及与戒烟相关的信念和过程之间的相互关系，还需要进一步的科学认识，以确定新的方法，为这一研究不足的人群提供戒烟的最佳支持。

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引用次数: 0

Effects of racial teasing on adolescent marijuana use and nicotine vaping: An analysis of the Virginia Youth Risk Behavior Surveillance System 种族取笑对青少年吸食大麻和尼古丁的影响：弗吉尼亚州青少年危险行为监测系统分析。

IF 3.7 2区医学 Q1 PSYCHOLOGY, CLINICAL

Addictive behaviors

Pub Date : 2024-10-02 DOI: 10.1016/j.addbeh.2024.108186

Kyzwana N. Caves , Prachi P. Chavan , Paul T. Harrell

Background

Despite adverse effects of tobacco and marijuana use on the adolescent brain, its use among youth remains high. Previous research shows associations between bullying and risks of substance use; less is known about racial teasing. This study examines associations of racial teasing, marijuana and/or electronic vapor products (EVP) use among adolescents, using 2021 Virginia Youth Risk Behavior Surveillance System (VYRBSS).

Methods

VYRBSS is a self-reported survey which collects information on experiences with racial teasing and substance use. This analysis included 3,083 high school students ≥ 12 years old. Descriptive analysis and logistic regression models were performed for categorical variables. Multivariable models were adjusted for confounders.

Results

Racial teasing was associated with marijuana (AOR 1.89; CI 1.43–2.48) and EVP use (AOR 2.52; CI 1.91–3.31). Compared to Whites; Asians, Blacks, and Latinos were more likely to report racial teasing. Older heterosexual females reported higher use of marijuana and EVP. Blacks reported greater use of marijuana, whereas Whites were more likely to use EVP. EVP use was higher in females (AOR 1.73, CI 1.34–2.23), bisexual youth (AOR 1.68, CI 1.23, 2.30) and poor mental health (AOR 1.49, CI 1.16, 1.92). Marijuana use was associated with bisexuality (AOR 1.75, CI 1.28–2.39) and poor mental health (AOR 1.62, CI 1.27–2.07) as well.

Conclusions

Every effort should be made by public health professionals in Virginia to prevent racial teasing among adolescents because it increases the odds of substance use, particularly in older females, youth who identify as bisexual, and those reporting poor mental health.

背景：尽管吸烟和吸食大麻会对青少年的大脑产生不良影响，但青少年使用烟草和大麻的比例仍然很高。以往的研究表明，欺凌与药物使用风险之间存在关联；但对种族取笑的了解较少。本研究利用 2021 年弗吉尼亚州青少年风险行为监测系统（VYRBSS）研究了青少年中种族取笑、使用大麻和/或电子蒸汽产品（EVP）之间的关联：VYRBSS 是一项自我报告调查，收集有关种族取笑和药物使用经历的信息。本分析包括 3,083 名年龄≥ 12 岁的高中生。对分类变量进行了描述性分析和逻辑回归模型。多变量模型对混杂因素进行了调整：种族取笑与吸食大麻（AOR 1.89；CI 1.43-2.48）和使用 EVP（AOR 2.52；CI 1.91-3.31）有关。与白人相比，亚洲人、黑人和拉丁美洲人更有可能报告受到种族戏弄。年龄较大的异性恋女性报告使用大麻和 EVP 的比例较高。黑人报告吸食大麻的比例更高，而白人则更有可能吸食EVP。女性（AOR 1.73，CI 1.34-2.23）、双性恋青年（AOR 1.68，CI 1.23-2.30）和心理健康状况不佳者（AOR 1.49，CI 1.16-1.92）使用EVP的比例较高。吸食大麻也与双性恋（AOR 1.75，CI 1.28-2.39）和心理健康状况不佳（AOR 1.62，CI 1.27-2.07）有关：弗吉尼亚州的公共卫生专业人员应尽一切努力防止青少年受到种族取笑，因为这会增加青少年使用药物的几率，尤其是年龄较大的女性、双性恋青少年以及精神健康状况较差的青少年。

{"title":"Effects of racial teasing on adolescent marijuana use and nicotine vaping: An analysis of the Virginia Youth Risk Behavior Surveillance System","authors":"Kyzwana N. Caves , Prachi P. Chavan , Paul T. Harrell","doi":"10.1016/j.addbeh.2024.108186","DOIUrl":"10.1016/j.addbeh.2024.108186","url":null,"abstract":"<div><h3>Background</h3><div>Despite adverse effects of tobacco and marijuana use on the adolescent brain, its use among youth remains high. Previous research shows associations between bullying and risks of substance use; less is known about racial teasing. This study examines associations of racial teasing, marijuana and/or electronic vapor products (EVP) use among adolescents, using 2021 Virginia Youth Risk Behavior Surveillance System (VYRBSS).</div></div><div><h3>Methods</h3><div>VYRBSS is a self-reported survey which collects information on experiences with racial teasing and substance use. This analysis included 3,083 high school students ≥ 12 years old. Descriptive analysis and logistic regression models were performed for categorical variables. Multivariable models were adjusted for confounders.</div></div><div><h3>Results</h3><div>Racial teasing was associated with marijuana (AOR 1.89; CI 1.43–2.48) and EVP use (AOR 2.52; CI 1.91–3.31). Compared to Whites; Asians, Blacks, and Latinos were more likely to report racial teasing. Older heterosexual females reported higher use of marijuana and EVP. Blacks reported greater use of marijuana, whereas Whites were more likely to use EVP. EVP use was higher in females (AOR 1.73, CI 1.34–2.23), bisexual youth (AOR 1.68, CI 1.23, 2.30) and poor mental health (AOR 1.49, CI 1.16, 1.92). Marijuana use was associated with bisexuality (AOR 1.75, CI 1.28–2.39) and poor mental health (AOR 1.62, CI 1.27–2.07) as well.</div></div><div><h3>Conclusions</h3><div>Every effort should be made by public health professionals in Virginia to prevent racial teasing among adolescents because it increases the odds of substance use, particularly in older females, youth who identify as bisexual, and those reporting poor mental health.</div></div>","PeriodicalId":7155,"journal":{"name":"Addictive behaviors","volume":"160 ","pages":"Article 108186"},"PeriodicalIF":3.7,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142395911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Historical change in associations between perceived risk, disapproval, and use of cannabis among young adults ages 19–30, 2011–2022 2011-2022 年 19-30 岁青壮年中感知到的风险、不赞成和吸食大麻之间关系的历史变化。

IF 3.7 2区医学 Q1 PSYCHOLOGY, CLINICAL

Addictive behaviors

Pub Date : 2024-10-02 DOI: 10.1016/j.addbeh.2024.108185

Yvonne M. Terry-McElrath, Yuk C. Pang, Megan E. Patrick

Background

The current study used U.S. young adult data to examine overall and age group-specific historical trends in (a) mean perceived risk and disapproval of cannabis use, and (b) risk/use and disapproval/use associations.

Methods

Data were collected from 2011 to 2022 from 16,492 respondents aged 19–30 in the national Monitoring the Future panel study. Trends in mean risk and disapproval overall and by age group (19–22, 23–26, 27–30) were modeled. Models regressing any past 30-day cannabis use on risk and disapproval controlled for sex, race/ethnicity, college education, population density, state cannabis policy, region, and year. Age group differences and historical trends in regression estimates from year-specific models were examined.

Results

From 2011 to 2022, overall mean perceived risk decreased from 3.08 (just over moderate) to 2.50 (between slight and moderate); mean disapproval decreased from 2.21 (between disapprove and strongly disapprove) to 1.66 (between don’t disapprove and disapprove). Higher risk and disapproval were independently associated with lower odds of past 30-day cannabis use overall (AORs 0.86 and 0.76, respectively); controlling for sociodemographics and state policy had virtually no impact on association strength. There were no significant age-related association differences. The risk/use association weakened from AOR 0.84 in 2011 to AOR 0.91 in 2022; the disapproval/use association remained stable (AORs 0.753 and 0.749).

Conclusions

Young adults now perceive cannabis as less risky and are less disapproving of using than they were a decade ago. Perceived risk has weakened as a cannabis use risk factor over time; disapproval has remained a stable risk factor.

背景：本研究使用美国年轻成人数据来研究以下方面的总体趋势和特定年龄组的历史趋势：(a)大麻使用的平均感知风险和不赞成程度，以及(b)风险/使用和不赞成/使用之间的关联：从 2011 年到 2022 年，在全国 "监测未来 "小组研究中收集了 16 492 名 19-30 岁受访者的数据。对总体和各年龄组（19-22、23-26、27-30）的平均风险和不赞成趋势进行了建模。将过去 30 天内吸食大麻的任何情况与风险和不认可进行回归的模型控制了性别、种族/民族、大学教育程度、人口密度、州大麻政策、地区和年份。研究了特定年份模型回归估计的年龄组差异和历史趋势：从 2011 年到 2022 年，总体平均感知风险从 3.08（略高于中等）降至 2.50（介于轻微和中等之间）；平均不赞成风险从 2.21（介于不赞成和非常不赞成之间）降至 1.66（介于不赞成和不赞成之间）。高风险和不赞成与过去 30 天使用大麻的总体几率较低独立相关（AOR 分别为 0.86 和 0.76）；控制社会人口统计学和州政策对关联强度几乎没有影响。与年龄相关的关联差异并不明显。风险/使用关联度从 2011 年的 AOR 0.84 减弱到 2022 年的 AOR 0.91；不赞成/使用关联度保持稳定（AOR 0.753 和 0.749）：结论：与十年前相比，现在的年轻人认为吸食大麻的风险较低，不赞成吸食大麻的程度也较低。随着时间的推移，感知风险作为使用大麻风险因素的作用有所减弱；不赞成仍然是一个稳定的风险因素。

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引用次数: 0

Longitudinal Interactions between Problematic Internet Gaming and Symptoms of Depression Among University Students: Differentiating Anhedonia and Depressed Mood 大学生问题性网络游戏与抑郁症状之间的纵向互动：区分失乐症和抑郁情绪

IF 3.7 2区医学 Q1 PSYCHOLOGY, CLINICAL

Addictive behaviors

Pub Date : 2024-10-01 DOI: 10.1016/j.addbeh.2024.108184

Xinyi Wei , Huiling Zhou , Qiaoyi Zheng , Lei Ren , Niya Chen , Pengcheng Wang , Chang Liu

Background/Objective: This study examines the interplay between problematic internet gaming (PIG) and depressive symptoms among university students, specifically anhedonia and depressed mood. Prior studies lacked distinction between these symptoms and had limited follow-ups. Method: The three-wave longitudinal study analyzed data from 1,720 university students (with an average age of 20 years and 49 % being female) using a random intercept cross-lagged panel model, which distinguished between-person and within-person effects. Results: At the between-person level, PIG was positively associated with two depressive symptoms. At the within-person level, PIG positively predicted future anhedonia. Besides, depressed mood positively predicted future PIG. Conclusions: Our results have identified PIG as a risk factor for anhedonia and depressed mood as a risk factor for PIG among university students.

背景/目的：本研究探讨了问题网络游戏（PIG）与大学生抑郁症状之间的相互影响，尤其是失乐症和抑郁情绪。之前的研究对这些症状缺乏区分，而且随访有限：三波纵向研究分析了1720名大学生（平均年龄20岁，49%为女性）的数据，采用随机截距交叉滞后面板模型，区分了人与人之间和人与人之间的影响：在人与人之间，PIG 与两种抑郁症状呈正相关。在人与人之间，PIG 与两种抑郁症状呈正相关。此外，抑郁情绪也能正向预测未来的 PIG：我们的研究结果表明，在大学生中，PIG 是导致失乐症的风险因素，而抑郁情绪则是导致 PIG 的风险因素。

引用次数: 0

A randomized controlled trial testing the efficacy of the eCHECKUP TO GO on drinking games participation and behavior among high school seniors 一项随机对照试验，测试 eCHECKUP TO GO 对高中生参与饮酒游戏和饮酒行为的影响。

IF 3.7 2区医学 Q1 PSYCHOLOGY, CLINICAL

Addictive behaviors

Pub Date : 2024-09-30 DOI: 10.1016/j.addbeh.2024.108183

Diana M. Doumas , Susan Esp , Rob Turrisi , Laura Bond , Shannon D. Glenn

Background

Among high school students, seniors report the highest levels of hazardous drinking behavior, including playing drinking games. Technology-based interventions are a promising approach for reducing hazardous drinking behavior among this age group. Objectives: This randomized controlled trial investigated the efficacy of the eCHECKUP TO GO, an online personalized feedback intervention, on reducing the frequency of playing drinking games, the number of drinks consumed while playing drinking games, and the number of drinks consumed on occasions when drinking games were played among high school seniors (ClinicalTrials.gov Identifier NCT03613818). Method: Participants were recruited from two high schools. Class periods were randomized to the intervention condition or an assessment-only control condition. Participants completed online surveys at baseline, 30-day, and 6-month assessments. The subsample in this study (N = 109) consisted of high-risk drinkers (i.e., students reporting binge drinking in the past two weeks at baseline). Results: We did not find any significant differences in frequency of playing drinking games between the intervention and control conditions. For number of drinks consumed, students in the intervention condition reported a significant reduction in the number of drinks consumed while playing drinking games (p < 0.01) and total number of drinks consumed on drinking game occasions (p < 0.04) at the 30-day follow-up relative to students in the control condition. Reductions within the intervention group were sustained at the 6-month follow-up. Conclusions: Results support the efficacy of the eCHECKUP TO GO for decreasing hazardous alcohol use among high school seniors.

背景：在高中生中，高三学生报告的危险饮酒行为水平最高，包括玩饮酒游戏。基于技术的干预措施是减少该年龄段学生危险饮酒行为的有效方法：本随机对照试验调查了 eCHECKUP TO GO（一种在线个性化反馈干预措施）对减少高三学生玩饮酒游戏的频率、玩饮酒游戏时的饮酒量以及玩饮酒游戏时的饮酒量的效果（ClinicalTrials.gov Identifier NCT03613818）：方法：从两所高中招募参与者。每节课随机分配干预条件或仅评估的对照条件。参与者在基线、30 天和 6 个月评估时完成在线调查。本研究的子样本（N = 109）由高危饮酒者组成（即在基线时报告在过去两周内大量饮酒的学生）：我们没有发现干预组和对照组在玩饮酒游戏的频率上有任何明显差异。就饮酒数量而言，干预条件下的学生在玩饮酒游戏时的饮酒数量明显减少（p 结论：干预条件下的学生在玩饮酒游戏时的饮酒数量明显减少：研究结果支持 eCHECKUP TO GO 在减少高三学生危险饮酒方面的功效。

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引用次数: 0

A randomized controlled trial evaluation of a smoking cessation and physical activity intervention delivered via telemedicine in the Norton Sound region of Alaska 在阿拉斯加诺顿湾地区通过远程医疗提供戒烟和体育锻炼干预的随机对照试验评估。

IF 3.7 2区医学 Q1 PSYCHOLOGY, CLINICAL

Addictive behaviors

Pub Date : 2024-09-30 DOI: 10.1016/j.addbeh.2024.108179

Judith J. Prochaska , Erin A. Vogel , Marily Oppezzo , Jordan Skan , Mariah Knox , Amy Chieng , Maria C. Crouch , Rachael C. Aikens , Matthew Schnellbaecher , Neal L. Benowitz

Objectives

Tobacco use disproportionately affects Alaska Native people. Physical activity may aid quitting smoking and provides health benefits. We tested telemedicine-delivered heart health interventions in Alaska’s Norton Sound region.

Methods

Alaska Native adults (N = 299, 51.5 % male, 60.5 % Inupiaq) with hypertension and/or hypercholesterolemia who smoked daily were randomized to intervention on smoking and physical activity (group 1) or traditional diet and medication adherence (group 2). Intention to change was not required for participation. Stage-tailored mailed workbooks and personalized reports were supported by telehealth counseling at baseline, 3, 6, and 12 months. Study outcomes were assessed at baseline, 3-, 6-, 12-, and 18-months (i.e., 6-months after the final counseling session). Smoking outcomes were self-reported 7-day point prevalence abstinence (7d-PPA),¹ bioconfirmed with urine anabasine; 24-hour quit attempts; and 50 % reduction in smoking. Self-reported physical activity outcomes were metabolic equivalent of task (MET) minutes and meeting moderate-to-vigorous physical activity (MVPA) guidelines.

Results

At baseline, participants averaged 12.4 (SD = 10.0) cigarettes/day, with 19.4 % prepared to quit smoking, and 81.6 % meeting MVPA guidelines. During the study, most (70.2 % group 1; 63.5 % group 2) reported a 24-hr quit attempt (p = 0.219), and Group 1 (53.6 %) was more likely than Group 2 (28.4 %) to use nicotine replacement therapy (NRT), OR = 2.92, p < 0.001. At 18-months, 40.5 % (group 1) and 32.5 % (group 2) had reduced their smoking by half or more (p = 0.343), and 10.8 % vs. 7.9 % (group 1 vs. 2) reported 7d-PPA with 4 % vs. 6 % (group 1 vs. 2) bioconfirmed. Time and baseline stage of change predicted 7d-PPA (p’s≤.015), with no group effect (p = 0.325). Activity levels did not significantly differ by group or time.

Conclusions

Telemedicine counseling supported NRT use but did not significantly affect behavioral outcomes.

目标：吸烟对阿拉斯加原住民的影响尤为严重。体育锻炼有助于戒烟并对健康有益。我们在阿拉斯加诺顿湾地区对远程医疗提供的心脏健康干预措施进行了测试：阿拉斯加原住民（N = 299，51.5% 为男性，60.5% 为伊努皮亚克人）中每天吸烟的高血压和/或高胆固醇血症患者被随机分为吸烟和体育锻炼干预组（第 1 组）或传统饮食和坚持服药干预组（第 2 组）。参加者无需有改变的意愿。在基线期、3 个月、6 个月和 12 个月时，通过远程医疗咨询提供分阶段定制的邮寄工作手册和个性化报告。研究结果在基线、3 个月、6 个月、12 个月和 18 个月（即最后一次咨询后 6 个月）进行评估。吸烟结果为自我报告的 7 天点戒烟率 (7d-PPA)，1 通过尿液阿那巴辛进行生物确认；24 小时戒烟尝试；以及吸烟量减少 50%。自我报告的体力活动结果是代谢当量任务（MET）分钟数和达到中到剧烈体力活动（MVPA）指南的要求：基线时，参与者平均每天吸烟 12.4 支（SD = 10.0），19.4% 的人准备戒烟，81.6% 的人符合 MVPA 指导原则。在研究过程中，大多数参与者（第一组 70.2%；第二组 63.5%）都曾尝试过 24 小时戒烟（P = 0.219），第一组（53.6%）比第二组（28.4%）更有可能使用尼古丁替代疗法（NRT），OR = 2.92，P 结论：远程医疗咨询支持尼古丁替代疗法的使用，但对行为结果没有显著影响。

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