Binge drinking, defined as consuming 4 or more drinks for females and 5 or more for males within a two-hour timeframe, is common among college students and associated with harmful health outcomes. Similarly, pain is prevalent in this population and can negatively affect students’ psychological, social, and academic functioning. However, the limited research examining associations between pain and alcohol-related constructs among college students has yielded inconsistent results. Individual differences in levels of reward and relief drinking motives (i.e., drinking in response to positive affect/social situations versus negative affect/stressful situations) may contribute to the complex, heterogeneous nature of these associations. The aim of the present study was to examine the moderating effects of reward and relief drinking on the association between pain and alcohol-related negative consequences in college students who binge drink. Participants were 436 college students who had engaged in past-month binge drinking. Most participants identified as White (66.7 %) and female (78.2 %), with a mean age of 19.62 (SD = 1.56) years. Results revealed significant moderating effects of both reward and relief motives on the association between pain at time 1 and alcohol-related negative consequences at time 2. In participants with either higher levels of relief or lower levels of reward drinking greater pain was significantly associated with a higher number of alcohol-related negative consequences. In participants demonstrating higher levels of reward drinking, greater pain was significantly associated with a lower number of alcohol-related negative consequences. Our work indicates targeting pain as a possible intervention to prevent alcohol-related negative consequences among those who report lower levels of reward or higher levels of relief drinking.