Addictive behaviors最新文献

{"title":"More high, less low? PTSD and the complex daily associations between cannabis use and depression in veterans","authors":"Jordan P. Davis ,&nbsp;Shaddy K. Saba ,&nbsp;Daniel Leightley ,&nbsp;Eric R. Pedersen ,&nbsp;John Prindle ,&nbsp;Jonathan Cantor ,&nbsp;Bistra Dilkina ,&nbsp;Emily Dworkin ,&nbsp;Angeles Sedano","doi":"10.1016/j.addbeh.2025.108593","DOIUrl":"10.1016/j.addbeh.2025.108593","url":null,"abstract":"<div><div><strong>Background and aims</strong>. Cannabis use is increasingly prevalent among U.S. veterans, with high rates of both recreational and problematic use. Veterans often use cannabis to manage symptoms associated with mental health problems such as depression and posttraumatic stress disorder (PTSD). Prior work has noted mixed results on the longitudinal associations between cannabis use and depression. Studying these associations at the daily level can lead to improved clarity. <strong>Design</strong>. The present study examined the daily associations between cannabis use and depression in veterans using dynamic structural equation modeling (DSEM). We also explored these associations for those veterans who screened positive for posttraumatic stress disorder (PTSD) compared to those who did not. Setting. All participants were recruited using advertisements from BuildClinical, an NIH approved recruitment vendor. <strong>Participants</strong>. The sample consisted of 74 veterans who provided daily data for 87 consecutive days. <strong>Measurement</strong>. Cannabis was assessed asking how many hours each individual spent high each day, depressed mood was assessed using a sliding scale from not depressed to very depressed each day, and PTSD was assessed using the PTSD checklist. <strong>Findings</strong>. Among the full veteran sample results revealed a bidirectional, negative, association. Specifically, on days when veterans reported greater depression, they reported fewer hours “high” the next day. Conversely, on days when veterans reported a greater number of hours high, they reported less depression the next day. Among veterans screening positive for PTSD, on days when they reported more depression, they reported fewer hours high the next day (no association was noted for cannabis use predicting depression). However, for those who did not screen positive for PTSD, on days when veterans reported greater number of hours high, they reported less depression the next day. <strong>Conclusions</strong>. These results highlight the need for further research on the effect of individual differences in cannabis use patterns among veterans with PTSD on health outcomes. Clinically, these results highlight the importance of targeting the pros and cons of cannabis use for depression symptom relief. Future research should incorporate daily objective measures of cannabis use to refine treatment strategies for veterans managing PTSD or depressive related distress.</div></div>","PeriodicalId":7155,"journal":{"name":"Addictive behaviors","volume":"175 ","pages":"Article 108593"},"PeriodicalIF":3.6,"publicationDate":"2025-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145881437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are older adults scheduled for lung cancer screening interested in trying electronic cigarettes when conventional smoking cessation treatment fails? A cross-sectional survey","authors":"Jaqueline C. Avila ,&nbsp;Nirotma Tripathi ,&nbsp;Caylin J. Marotta ,&nbsp;Caitlin E. McCann ,&nbsp;Michele Reyen ,&nbsp;Jennifer S. Haas ,&nbsp;Elyse R. Park ,&nbsp;Nancy A. Rigotti","doi":"10.1016/j.addbeh.2025.108592","DOIUrl":"10.1016/j.addbeh.2025.108592","url":null,"abstract":"<div><h3>Introduction</h3><div>Lung cancer screening (LCS) provides an opportunity to offer tobacco cessation treatment, but most people who smoke are unable to quit, even with support. They might benefit from switching to electronic cigarettes (EC), but their perceptions and interest in EC use are unknown.</div></div><div><h3>Methods</h3><div>Adults who participated in a smoking cessation clinical trial offered at LCS and still smoked at trial completion were surveyed about their interest in trying EC (primary outcome). Independent variables were EC use history and perceptions of health risks and benefits of EC vs combustible cigarettes (CC). Logistic regression models tested the association of EC use and perceptions with interest in trying EC, adjusting for covariates.</div></div><div><h3>Results</h3><div>204/359 eligible participants (56.8 %) completed the survey. 56.4 % had never tried EC, and 30.9 % were interested in trying EC in the future. 60.3 % believed EC to be as or more harmful than CC, but 60.8 % thought that EC were likely to help people cut down smoking. Interest in trying EC was positively associated with previous EC experience (OR: 2.08, 95 %CI:1.1–3.9), and the belief that EC were less harmful than CC (OR: 8.9, 95 %CI: 3.2–24.9), or that EC can help people cut down on smoking (OR: 8.6, 95 %CI: 3.5–21.2).</div></div><div><h3>Conclusions</h3><div>Adults undergoing LCS who smoke after cessation treatment ends believe that EC can help people cut down, but they overestimate EC health risks. A positive perception of EC is associated with greater interest in trying EC. Education to correct EC misperceptions might increase interest in trying EC as a harm reduction tool among those who smoke.</div></div>","PeriodicalId":7155,"journal":{"name":"Addictive behaviors","volume":"175 ","pages":"Article 108592"},"PeriodicalIF":3.6,"publicationDate":"2025-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145835408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal study of probable compulsive sexual behavior disorder and problematic pornography use profiles: their prospective impact on psychopathology during wartime","authors":"Yaniv Efrati ,&nbsp;Dvora Shmulewitz ,&nbsp;Vera Skvirsky ,&nbsp;Merav Vider ,&nbsp;Ariel Kor ,&nbsp;Shaul Lev-Ran ,&nbsp;Mario Mikulincer","doi":"10.1016/j.addbeh.2025.108589","DOIUrl":"10.1016/j.addbeh.2025.108589","url":null,"abstract":"<div><div>Research has shown that compulsive sexual behavior disorder (CSBD) and problematic pornography use (PPU) are associated with mental disorders. However, less is known about how trajectories of probable CSBD and PPU prospectively contribute to the evolvement of psychopathology during a stressful period. In this study, we applied latent profile analysis (LPA) to identify distinct latent profiles of participants’ probable CSBD and PPU across 2018 and 2022, prior to the October 2023 attack in Israel (Iron Swords War), and to examine how these profiles prospectively predict the evolvement of psychopathology during wartime. A longitudinal study surveying the in a community sample of Jewish population in Israel, aged 18–70, was conducted before October 7th 2023 attack and during the subsequent war. Participants completed self-report measures of probable CSBD and PPU, psychopathology (global distress, emotional dysregulation, PTSD, anxiety, depression), and level and kind of exposure to the October 7th attack. LPA revealed four distinct probable CSBD/PPU profiles during the two pre-war waves: ‘no disorder’ (n = 952; 80.54 %),‘recovery’ (n = 138; 11.68 %),‘delayed onset’ (n = 50; 4.23 %), and ‘chronic’ (n = 42; 3.55 %). Using T3 and T4 for the trajectory results, the no-disorder group consistently demonstrated the lowest levels of psychopathology and out-of-control behaviors during wartime, while the chronic group reported significantly higher distress; differential impacts among probable CSBD/PPU trajectory groups showed that the no-disorder group reported decreasing anxiety and depression during wartime in contrast to the chronic group that experienced increased PTSD severity. This research offers a nuanced understanding of probable CSBD/PPU profiles, showing how these profiles impact the evolvement of psychopathology during wartime.</div></div>","PeriodicalId":7155,"journal":{"name":"Addictive behaviors","volume":"175 ","pages":"Article 108589"},"PeriodicalIF":3.6,"publicationDate":"2025-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145822446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perceptions of negative reinforcement in the natural environment: Characterizing subjective alcohol- and cannabis-contingent relief","authors":"Andrea M. Wycoff ,&nbsp;Timothy J. Trull","doi":"10.1016/j.addbeh.2025.108590","DOIUrl":"10.1016/j.addbeh.2025.108590","url":null,"abstract":"<div><div>Negative reinforcement is a major component of etiologic models of addiction. Recent work using ecological momentary assessment (EMA) implicates subjective substance-contingent relief as a negative reinforcer of substance use rather than improvements in negative affect. This pre-registered secondary data analysis tested predictors of subjective alcohol- and cannabis-contingent relief to understand what factors contribute to perceived relief, if not actual improvements in negative affect. Adults (<em>N</em> = 87, mean age 25.2 years, 60.2% female, 85.2% white) who reported using alcohol and cannabis simultaneously at least twice per week completed 14 days of EMA. Morning surveys assessed hypothetical relief expectancies for that day. All surveys assessed affect, craving, alcohol and cannabis use, and subjective relief and pleasure from use. Multilevel models tested predictors of subjective relief. During alcohol use moments (<em>n</em> = 868), drinking-contingent pleasure (<em>b</em> = 0.25, <em>SE</em> = 0.06, <em>p</em> &lt; .001) and relief expectancy reported that morning (<em>b</em> = 0.29, <em>SE</em> = 0.10, <em>p</em> = .005) predicted higher drinking-contingent relief. During cannabis use moments (<em>n</em> = 1519), cannabis-contingent pleasure (<em>b</em> = 0.29, <em>SE</em> = 0.06, <em>p</em> &lt; .001) and relief expectancy reported that morning (<em>b</em> = 0.33, <em>SE</em> = 0.11, <em>p</em> = .004) predicted higher cannabis-contingent relief. Changes in affect and craving were not associated with relief. Results highlight subjective pleasure, which is more consistent with positive reinforcement, as a potential driver of perceived relief. Future work should disentangle the predictive direction of relief and pleasure to inform reinforcement mechanisms. Results also highlight the role of expectancies in subjective perceptions of use, above and beyond measurable changes in mood and craving. Collectively, findings add to a growing body of work seeking to articulate reinforcement processes in the natural environment.</div></div>","PeriodicalId":7155,"journal":{"name":"Addictive behaviors","volume":"175 ","pages":"Article 108590"},"PeriodicalIF":3.6,"publicationDate":"2025-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145829087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional disability and the risk of subsequent smoking initiation: A prospective cohort analysis","authors":"Yusuff Adebayo Adebisi ,&nbsp;Najim Z. Alshahrani","doi":"10.1016/j.addbeh.2025.108588","DOIUrl":"10.1016/j.addbeh.2025.108588","url":null,"abstract":"<div><h3>Background</h3><div>Smoking initiation remains a major public health concern, yet little is known about whether functional disability independently increases the risk of becoming a smoker.</div></div><div><h3>Methods</h3><div>We conducted a prospective cohort analysis using data from Waves 10 (2018–2019, baseline) and 14 (2022–2023, follow-up) of the UK Household Longitudinal Study. The analytic sample included 20,529 adults who were non-smokers at baseline and were prospectively followed over four years to assess smoking initiation at Wave 14. Functional disability was assessed across twelve domains; mobility, lifting or carrying objects, manual dexterity, continence, hearing, sight, physical coordination, personal care, memory/concentration/learning/understanding, communication/speech, recognising physical danger, and other health problems or disabilities; and was operationalised based on its presence, number of affected domains, and specific type of limitation reported. Modified Poisson regression with robust standard errors was used to estimate adjusted relative risks (RRs) of smoking initiation, controlling for age, sex, education, ethnicity, and urban/rural residence.</div></div><div><h3>Results</h3><div>At baseline, 25.1 % of participants (n = 5161) reported at least one functional disability. By follow-up, 379 participants (1.9 %) had initiated smoking. Individuals with functional disabilities had a higher risk of smoking initiation (RR = 1.42, 95 % CI: 1.12–1.80, p = 0.004) after adjustment. A significant trend was observed across increasing numbers of functional disabilities (p-trend &lt; 0.001), with elevated risks among individuals reporting two or more (RR = 1.80, 95 % CI: 1.33–2.42, p &lt; 0.001). Among new smokers, individuals with functional disabilities were also more likely to smoke ≥ 10 cigarettes per day (RR = 1.40, 95 % CI: 1.04–1.64, p = 0.020). Domain-specific analyses showed that mobility limitations (RR = 1.83, 95 % CI: 1.33–2.50, p &lt; 0.001), lifting or carrying impairments (RR = 1.90, 95 % CI: 1.40–2.57, p &lt; 0.001), personal care limitations (RR = 1.95, 95 % CI: 1.19–3.18, p = 0.008), and difficulties recognising physical danger (RR = 2.59, 95 % CI: 1.15–5.81, p = 0.021) were most strongly associated with smoking initiation.</div></div><div><h3>Conclusions</h3><div>Functional disability is associated with an increased risk of smoking initiation. These findings highlight the need for inclusive tobacco prevention strategies that address the unique vulnerabilities and barriers faced by people with functional impairments.</div></div>","PeriodicalId":7155,"journal":{"name":"Addictive behaviors","volume":"175 ","pages":"Article 108588"},"PeriodicalIF":3.6,"publicationDate":"2025-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145765753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Consumer engagement with the US alcohol health warning: A nationally representative study","authors":"Marissa G. Hall ,&nbsp;Phoebe R. Ruggles ,&nbsp;Carolyn Chelius ,&nbsp;Cristina J.Y. Lee ,&nbsp;Callie Whitesell ,&nbsp;Allison J. Lazard ,&nbsp;Noel T. Brewer ,&nbsp;Thomas K. Greenfield ,&nbsp;Anna H. Grummon","doi":"10.1016/j.addbeh.2025.108586","DOIUrl":"10.1016/j.addbeh.2025.108586","url":null,"abstract":"<div><h3>Background</h3><div>The US has had the same health warning on alcohol containers since 1989. We sought to estimate consumer noticing, reading, and recall of the current US alcohol health warning.</div></div><div><h3>Methods</h3><div>We recruited a nationally representative sample of 1,036 US alcohol consumers ages 21 + years. Participants completed an online survey in 2024 that assessed whether they had noticed or read the current US alcohol health warning, as well as aided recall of the topics in the warning. Analyses used multivariable logistic regression to examine correlates of reading the warning.</div></div><div><h3>Results</h3><div>About half of participants (52 %) reported noticing the alcohol health warning the last time they saw an alcohol container and 27 % reported reading the warning in the past month. Reading the warning was more common among Black people (vs. white, 43 % vs. 23 %, <em>p</em> = 0.02). When prompted with a list of possible warning topics, only 4 % of participants correctly recalled all five topics in the warning. Most (60 %) recalled that the warning discussed pregnancy, but less than half recalled the remaining topics in the warning (46 % driving a car, 44 % operating machinery, 41 % birth defects, and 33 % health problems). Recall was modestly higher among those who read the warning in the past month (improvements of 5–16 percentage points) compared to those who did not. However, fewer than two-thirds of people who said they had read the warning recalled each topic.</div></div><div><h3>Conclusions</h3><div>The current US alcohol warning fails to actively engage many alcohol consumers. The US should require new, rotating alcohol warnings designed to heighten engagement and better inform consumers.</div></div>","PeriodicalId":7155,"journal":{"name":"Addictive behaviors","volume":"175 ","pages":"Article 108586"},"PeriodicalIF":3.6,"publicationDate":"2025-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145922168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social attunement and alcohol use: The role of age and gender","authors":"Christophe Romein ,&nbsp;Karis Colyer-Patel ,&nbsp;Emese Kroon ,&nbsp;Helle Larsen ,&nbsp;Hanan El Marroun ,&nbsp;Janna Cousijn","doi":"10.1016/j.addbeh.2025.108587","DOIUrl":"10.1016/j.addbeh.2025.108587","url":null,"abstract":"<div><h3>Background</h3><div>Alcohol use typically peaks during adolescence and early adulthood, when its social reinforcement value is high, and then decreases as individuals take on more adult-like responsibilities. The present study investigates whether social attunement (SA) plays a role in higher alcohol use in adolescence as well as a lower alcohol use when aging.</div></div><div><h3>Methods</h3><div>This online study included an international sample of 683 alcohol users (16 – 81yrs). Participants completed a SA Questionnaire, an Implicit SA task (ISAT), and measures of alcohol use. The ISAT measured SA as the change in willingness to drink in response to peer feedback between two blocks of images representing social alcohol, social non-alcohol, and social non-drinking settings. Linear regressions were conducted to assess the association between SA and alcohol use, and the role of age and gender in these associations.</div></div><div><h3>Results</h3><div>Unlike expected, interactions between age and SA did not predict alcohol use across social situations regardless of feedback condition. However, exploratory post-hoc analyses using the total SA score per social condition showed significant interactions between age and SA in predicting alcohol use in social situations involving non-alcoholic or no drinks. In social non-alcohol drinking settings, SA was positively associated with alcohol use among younger participants, but this association became negative in older individuals. Contrastingly, in the social non-drinking condition, SA was negatively associated with alcohol use among younger participants, but this association became positive in older individuals.</div></div><div><h3>Discussion</h3><div>Depending on age and social setting, SA can both be a risk- or protective factor for alcohol use.</div></div>","PeriodicalId":7155,"journal":{"name":"Addictive behaviors","volume":"175 ","pages":"Article 108587"},"PeriodicalIF":3.6,"publicationDate":"2025-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145822462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating different patterns of problematic internet use using a unified self-report measure based on the ICD-11 framework: Psychometric properties of the Italian version of the ACSID-11","authors":"Simon Ghinassi ,&nbsp;Giulia Fioravanti ,&nbsp;Maria Anna Donati ,&nbsp;Caterina Primi ,&nbsp;Yura Loscalzo ,&nbsp;Silvia Casale","doi":"10.1016/j.addbeh.2025.108580","DOIUrl":"10.1016/j.addbeh.2025.108580","url":null,"abstract":"<div><div>The ACSID-11 was developed to assess five patterns of problematic Internet use—namely, gaming disorder, compulsive online shopping, problematic online pornography use, problematic social networks use, and online gambling disorder—using a unified set of items grounded in the ICD-11 framework. The present study examined the psychometric properties of the Italian version of the ACSID-11. A sample of 1263 participants (76.70 % females, <em>M</em>_age = 40.89, <em>SD</em> = 13.72, range = 18–83) completed the ACSID-11 and was included in the analysis of its factorial structure. A series of Confirmatory Factor Analyses (CFAs) confirmed the assumed four-factorial structure (i.e., Impaired Control, Increased Priority, Continuation/Escalation of Use, Functional Impairment in Daily Life/Marked Distress), which was superior to the unidimensional solution for all the patterns of problematic Internet use. Moreover, the second-order models demonstrated comparable fit to the four-factor solutions and supported the use of an overall composite score. A subsample of 999 participants (76.40 % females, M = 40.59, SD = 13.67, range = 18–83) also completed the Patient Health Questionnaire-9, the General Anxiety Disorder Scale-7, and the Satisfaction with Life Scale, whereas the number of participants who completed the measures used to assess convergent validity varied depending on whether they reported engaging in the corresponding behavior or not<strong>.</strong> Convergent and criterion validity were supported. These findings suggest that the Italian version of this unified item set is a valid and reliable tool for consistently assessing different patterns of problematic Internet use.</div></div>","PeriodicalId":7155,"journal":{"name":"Addictive behaviors","volume":"174 ","pages":"Article 108580"},"PeriodicalIF":3.6,"publicationDate":"2025-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145758598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hippocampal transcranial temporal interference stimulation reduced craving in methamphetamine use disorder","authors":"Dongcheng Wang ,&nbsp;Zhe Du ,&nbsp;Xinwen Wen ,&nbsp;Qihan Li ,&nbsp;Yi Liu ,&nbsp;Junjie Tang ,&nbsp;Chunhao Shui ,&nbsp;Peijie Yu ,&nbsp;Likun Yang ,&nbsp;Pengquan Tu ,&nbsp;Xin Liu ,&nbsp;Cunfeng Yuan ,&nbsp;Dahua Yu ,&nbsp;Tengfei Ma ,&nbsp;Kai Yuan","doi":"10.1016/j.addbeh.2025.108581","DOIUrl":"10.1016/j.addbeh.2025.108581","url":null,"abstract":"<div><h3>Background</h3><div>Craving is a key challenge in treating methamphetamine use disorder (MUD). The memory reconsolidation theory indicates that interference with MUD after drug memory retrieval helps to reduce craving. Previous studies have demonstrated the importance of the hippocampus in memory consolidation, but traditional non-invasive interventions cannot effectively locate and intervene in the hippocampus. Although tTIS can accurately intervene in deep brain regions, it is still unknown whether tTIS intervention on the MUD hippocampus is effective in reducing craving.</div></div><div><h3>Method</h3><div>A total of 40 male participants with MUD were randomized to active or sham tTIS. Active tTIS delivered a 10 Hz electric field to the hippocampus for 20 min per day over 10 consecutive days, while sham stimulation lasted only 1 min per day during the same period. We also assessed its effects on craving, cognitive function and emotional symptoms at baseline, post intervention and one month follow-up.</div></div><div><h3>Results</h3><div>A two-way repeated-measures analysis of variances (ANOVAs) on drug cue-induced craving revealed a significant group × time interaction effect (F (2, 108) = 5.652, P = 0.005). Post hoc paired <em>t</em>-test indicated a significant decrease in craving in the active tTIS group (t = 5.04, P = 0.002) after the intervention and one month follow-up (t = 6.04, P &lt; 0.001). In contrast, no significant changes were observed in the sham group.</div></div><div><h3>Conclusions</h3><div>In this trial, 10 Hz tTIS was effective for METH craving reduction in MUD. Further trials are needed to explore neural mechanisms of tTIS.</div></div>","PeriodicalId":7155,"journal":{"name":"Addictive behaviors","volume":"174 ","pages":"Article 108581"},"PeriodicalIF":3.6,"publicationDate":"2025-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145733306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alcohol demand and alcohol use disorder among adolescents and young adults who drink heavily: An exploratory analysis including sex differences","authors":"Kathryn S. Gex ,&nbsp;ReJoyce Green ,&nbsp;Samuel F. Acuff ,&nbsp;Anna E. Kirkland ,&nbsp;Brittney D. Browning ,&nbsp;Rachel L. Tomko ,&nbsp;Kevin M. Gray ,&nbsp;Lindsay M. Squeglia","doi":"10.1016/j.addbeh.2025.108583","DOIUrl":"10.1016/j.addbeh.2025.108583","url":null,"abstract":"<div><div>Behavioral economic alcohol demand, or the reward value of alcohol consumption, consistently shows associations between alcohol use and alcohol use disorder (AUD) in adults, yet research within clinical youth populations (considered to be ages 15–24) remains limited. It is critical to better understand how demand functions in clinical youth populations to predict alcohol related outcomes. Moreover, given the narrowing gap between male and female youth in alcohol use prevalence in recent years, exploring sex differences in alcohol demand and its role in the relationship between demand, alcohol use, alcohol-related problems, and AUD is important. The current study used data from two samples of adolescents and young adults from the community (N = 127; ages 16–25, M_age = 20.57, SD = 2.27; 56.35 % female; 91.27 % white), one treatment seeking (n = 94) and one non-treatment seeking (n = 33), to examine the relationship between demand indices and alcohol use outcomes and to explore the role of sex in these relationships. Demand intensity (the number of standard drinks a person would consume if drinks were $0), O_max (maximum money spent across prices, i.e., number of drinks purchased × price), and price sensitivity (α; the rate alcohol consumption decreases as prices increase) were significantly associated with alcohol use quantity and frequency outcomes, but not alcohol-related problems or AUD severity. Although male youth had significantly greater intensity relative to female youth, intensity was more strongly associated with drinking days in female youth. Broadly, our findings support the importance of evaluating alcohol demand in clinical youth as well as sex differences in alcohol demand. Our results also speak to the need for interventions targeting sex-specific mechanisms and moderators of alcohol use.</div></div>","PeriodicalId":7155,"journal":{"name":"Addictive behaviors","volume":"174 ","pages":"Article 108583"},"PeriodicalIF":3.6,"publicationDate":"2025-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145733223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}