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Treatment strategy for severe trauma patients requiring aortic occlusion for impending cardiopulmonary arrest in the hybrid emergency room 在混合急诊室对因即将发生心肺骤停而需要主动脉闭塞的严重外伤患者的治疗策略。
IF 1.6 Pub Date : 2024-01-29 DOI: 10.1002/ams2.928
Shuhei Maruyama, Daiki Wada, Tomoyuki Yoshihara, Fukuki Saito, Kazuhisa Yoshiya, Yasushi Nakamori, Yasuyuki Kuwagata

Aim

Computed tomography (CT) is useful in trauma care. Severely ill trauma patients may not tolerate whole-body CT even without patient transfer. This study examined clinical flow of severe trauma patients requiring aortic occlusion (AO) such as resuscitative thoracotomy or REBOA in the hybrid emergency room (ER) and investigated patient clinical courses prioritizing CT first versus resuscitation including AO first.

Methods

This retrospective, single-center observational study included consecutive trauma patients visiting our ER between May 2016 and February 2023. Patients were divided into the CT first group (whole-body CT preceded AO) and AO first group (AO preceded whole-body CT) and into two subgroups: AO after CT (AO/interventions for hemorrhage performed just after CT in the CT first group), and CT after AO (CT or damage control surgery performed after AO in the AO first group). We investigated 28-day survival rates.

Results

Survival probability by TRISS method was 49% (range: 3.3–94) in the CT first group (n = 6) and 20% (range: 0.7–45) in the AO first group (n = 7). Actual 28-day survival rates were 50% and 57%, respectively. Survival rates of the AO after CT subgroup (CT first group) were 75% (3/4) and 0% (0/2), respectively, and those of the CT after AO subgroup (AO first group) were 25% (1/4) and 100% (3/3), respectively.

Conclusion

In severe trauma patients with low predicted probability of survival treated in the hybrid ER, survival rates might be better if resuscitation including AO is performed before CT and if damage control surgery is performed first before CT.

目的:计算机断层扫描(CT)在创伤护理中非常有用。病情严重的创伤患者可能无法忍受全身 CT,即使不转移患者也是如此。本研究考察了在混合急诊室(ER)需要进行主动脉闭塞(AO)(如复苏性开胸术或 REBOA)的重症创伤患者的临床流程,并研究了优先 CT 与优先复苏(包括 AO)的患者临床过程:这项回顾性、单中心观察研究纳入了2016年5月至2023年2月期间在本急诊室就诊的连续创伤患者。患者被分为 CT 先行组(全身 CT 先于 AO)和 AO 先行组(AO 先于全身 CT)以及两个亚组:AO后CT组(CT先行组在CT后进行AO/出血干预)和AO后CT组(AO先行组在AO后进行CT或损伤控制手术)。我们对 28 天的存活率进行了调查:结果:根据 TRISS 法,先行 CT 组(6 人)的存活率为 49%(范围:3.3-94),先行 AO 组(7 人)的存活率为 20%(范围:0.7-45)。28天实际存活率分别为50%和57%。AO后CT亚组(CT先行组)的存活率分别为75%(3/4)和0%(0/2),AO后CT亚组(AO先行组)的存活率分别为25%(1/4)和100%(3/3):结论:对于在混合急诊室接受治疗的预测存活概率较低的严重创伤患者,如果在 CT 前进行包括 AO 在内的复苏,以及在 CT 前首先进行损伤控制手术,存活率可能会更高。
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引用次数: 0
Reviewer Summary for Acute Medicine & Surgery 急诊内外科》审稿人简介
IF 1.6 Pub Date : 2024-01-28 DOI: 10.1002/ams2.927

Score Completion Date Range: Between Jan 1, 2023 and Dec 31, 2023.

The publication of invaluable papers in the Acute Medicine & Surgery depends on the prompt, careful review of submitted manuscripts. We would like to thank the Editorial Board members, and the following experts for reviewing manuscripts from January 1, 2023, to December 31, 2023.

Abe, Ryuzo

Abe, Yoshinobu

Akahoshi, Tomohiko

Amagasa, Shunsuke

Anan, Hideaki

Aokage, Toshiyuki

Aoki, Makoto

Aoki, Yoshihiro

Araki, Takashi

Arimoto, Hideki

Atsumi, Takahiro

Azuma, Kazunari

Banerjee, Pushpal

Boran, Maruf

Doi, Kent

Doi, Tomoaki

Ebihara, Takayuki

Egi, Moritoki

Endo, Tomoyuki

Enomoto, Yuki

Fujii, Tomoko

Fujiogi, Michimasa

Fujisaki, Noritomo

Fujishima, Seitaro

Fujita, Motoki

Fujita, Satoshi

Fujizuka, Kenji

Fukuda, Tatsuma

Fukushima, Hidetada

Funabiki, Tomohiro

Funakoshi, Hiraku

Funazaki, Toshikazu

Furukawa, Makoto

Gando, Satoshi

Goto, Tadahiro

Goto, Yoshikazu

Grensemann, Jörn

Hagiwara, Yusuke

Hanada, Hiroyuki

Hanajima, Tasuku

Hanaki, Nao

Harada, Masahiro

Hatakeyama, Junji

Hattori, Noriyuki

Hayakawa, Koichi

Hayakawa, Mineji

Hayashi, Yasuyuki

Hayashida, Kazuyuki

Hibino, Seikei

Hifumi, Toru

Hirose, Tomoya

Homma, Hiroshi

Homma, Yosuke

Hongo, Takashi

Hosomi, Sanae

Hoyt, David B.

Iba, Toshiaki

Ichiba, Shingo

Ichiba, Toshihisa

Ikeda, Hiroto

Ikezoe, Takayuki

Imai, Yoshiro

Imamoto, Toshiro

Imamura, Hiroshi

Inaba, Mototaka

Inamasu, Joji

Inokuchi, Koichi

Inoue, Akihiko

Inoue, Shigeaki

Inoue, Yoshiaki

Ishida, Kenichiro

Ishihara, Satoshi

Ishikura, Hiroyasu

Isokawa, Shutaro

Iwase, Hiroaki

Iwashita, Yoshiaki

Izawa, Yoshimitsu

Jörres, Achim

Kaita, Yasuhiko

Kajino, Kentaro

Kanda, Jun

Kaneko, Tadashi

Kasaoka, Shunji

Kashiura, Masahiro

Kasugai, Daisuke

Katayama, Yusuke

Kawazoe, Yu

Kikutani, Kazuya

Kinoshita, Takahiro

Kiriu, Nobuaki

Kiyota, Kazuya

Koami, Hiroyuki

Kobata, Hitoshi

Kondo, Hiroshi

Kondo, Yutaka

Kudo, Daisuke

Kurihara, Tomohiro

Kuroda, Yasuhiro

Kurozumi, Taketo

Matsumura, Yosuke

Matsushima, Asako

Matsushima, Hisao

Matsuyama, Shigenari

Matsuyama, Tasuku

Mayumi, Toshihiko

Mitsunaga, Toshiya

Miyamichi, Ryosuke

Miyamoto, Kyohei

Mizushima, Yasuaki

Mohara, Jun

Morimura, Naoto

Morishita, Koji

Moriya, Takashi

Muronoi, Tomohiro

Muroya, Takashi

Nagashima, Futoshi

Naito, Hiromichi

Nakada, Taka-aki

评分完成日期范围:2023 年 1 月 1 日至 2023 年 12 月 31 日之间。《急诊医学与外科》杂志能否发表有价值的论文,取决于对所投稿件的及时、认真审阅。我们衷心感谢编委会成员以及以下专家在 2023 年 1 月 1 日至 2023 年 12 月 31 日期间对稿件的审阅。阿部龙三、赤星义信、天笠智彦、阿南俊介、青木秀明、青木俊之、青木诚、荒木义弘、庵本隆史、渥美秀树、阿沼隆弘、班纳吉和成、伯兰普什帕尔、戸井马鲁夫、戸井肯特、戸井智明、戸井裕明、戸井裕明、戸井裕明、戸井裕明、戸井裕明、戸井裕明、戸井裕明、戸井裕明、戸井裕明、戸井裕明、戸井裕明、KentDoi, TomoakiEbihara, TakayukiEgi, MoritokiEndo, TomoyukiEnomoto, YukiFujii, TomokoFujiogi, MichimasaFujisaki, NoritomoFujishima, SeitaroFujita, MotokiFujita, SatoshiFujizuka, KenjiFukuda, TatsumaFukushima、HidetadaFunabiki, TomohiroFunakoshi, HirakuFunazaki, ToshikazuFurukawa, MakotoGando, SatoshiGoto, TadahiroGoto, YoshikazuGrensemann, JörnHagiwara, YusukeHanada, HiroyukiHanajima, TasukuHanaki, NaoHarada、畠山雅弘、服部淳治、早川典之、早川幸一、林峰二、林康之、日比野和幸、日淵聖慶、廣瀨徹、本間智也、本乡洋介、細見隆史、真江弘伊、大衛 B.Iba, ToshiakiIchiba, ShingoIchiba, ToshihisaIkeda, HirotoIkezoe, TakayukiImai, YoshiroImamoto, ToshiroImamura, HiroshiInaba, MototakaInamasu, JojiInokuchi, KoichiInoue, AkihikoInoue, ShigeakiInoue, YoshiakiIshida, KenichiroIshihara, SatoshiIshikura, HiroyasuIsokawa、小畑博之、近藤仁、近藤弘、工藤丰、栗原大辅、黑田智弘、黑泉康弘、松村武人、松岛洋介、松岛麻子、松山久雄、松山重成、真由美太淑、三永俊彦、宫道俊也、宫本良介、水岛恭平、小原康明、森村淳、森下直人、森谷浩二、村野井隆、室屋智弘、长岛隆、内藤二俊、中田弘道、中江孝明、中川肇、中森幸子、中村康、中尾义嗣、吳敦则、西村明伟、西村武史、西村裕史、西村裕史、西村裕史、西村裕史、西村裕史、西村裕史、西村裕史、西村裕史、西村裕史、西村裕史、西村裕史、西村武、西山哲郎、西山圭、野村隆、野坂治、落合信行、大部秀信、大下弘行、冈田伸一郎、冈田元、大村阳平、大西武、小野伸弥、大泽恒、大菅严、大塚敬吾、大谷昭典、坂井典夫、坂本智彦、坂井裕彦、坂井裕彦、坂井裕彦、坂井裕彦、坂井裕彦、坂井裕彦、坂井裕彦、坂井裕彦、坂井裕彦、坂井裕彦、坂井裕彦、坂井裕彦、坂井裕彦、坂井裕彦、坂井裕彦、坂本智彦、坂本绫香、崎山裕一郎、樱井义雄、笹崎敦志、笹崎淳一、笹崎信雄、笹崎亮、笹戸马可、笹戸信博、笹戸哲也、笹戸霞美、关根英俊、柴桥和彦、柴泽敬太、姫孝之、清水信明、清水K、植原健一郎、植村博文、植海修司、植村勇夫、臼井丰、和田良介、渡边武、药师寺博明、山田宏正、山川典明、山本一马、山下良、柳川典夫、柳力酉一、法兹里洋、横堀喜久男、汤本昌司、张哲也、钟恒
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引用次数: 0
Long-term psychiatric disorders in families of severe COVID-19 patients 严重 COVID-19 患者家属的长期精神障碍。
IF 1.6 Pub Date : 2024-01-26 DOI: 10.1002/ams2.926
Kasumi Shirasaki, Toru Hifumi, Moe Sekiguchi, Shutaro Isokawa, Yusuke Nakao, Shinobu Tanaka, Shinsuke Hashiuchi, Ryosuke Imai, Norio Otani

Aim

The present study aimed to describe in detail the changes to and assess the risk factors for poor long-term outcomes of psychiatric disorders in families of COVID-19 patients.

Methods

A single-center, retrospective study using questionnaires. Family members of patients admitted to the intensive care unit (ICU) with severe COVID-19 participated. Psychiatric disorders refer to the psychological distress such as anxiety, depression, and posttraumatic stress disorder (PTSD) experienced by the patient's family.

Results

Forty-six family members completed the survey and were analyzed. Anxiety, depression, and PTSD occurred in 24%, 33%, and 2% of family members, respectively, and psychiatric disorders occurred in 39%. On multivariable analysis, living in the same house with the patient was independently associated with a lower risk of psychiatric disorders in families of COVID-19 patients (OR, 0.180; 95% CI, 0.036–0.908; p = 0.038). Furthermore, four family members overcame psychiatric disorders, and six family members newly developed psychiatric disorders during the one-year follow-up period.

Conclusion

Approximately 40% of family members had long-term psychiatric disorders, and some of them overcame the psychiatric disorders, and some newly developed psychiatric disorders over the one-year follow-up. Living in the same house with the patient was possibly significantly associated with the reduction of long-term symptoms of psychiatric disorders, but this result must be interpreted with care. Further large studies are needed to examine the factors associated with the long-term mental status of family members.

目的:本研究旨在详细描述 COVID-19 患者家庭中精神病长期不良后果的变化并评估其风险因素:方法:采用问卷调查的方式进行单中心回顾性研究。重症监护病房(ICU)收治的重症 COVID-19 患者的家属参加了此次研究。精神障碍是指患者家属所经历的焦虑、抑郁和创伤后应激障碍(PTSD)等心理困扰:46名家庭成员完成了调查并进行了分析。焦虑症、抑郁症和创伤后应激障碍分别出现在 24%、33% 和 2% 的家庭成员中,而精神障碍则出现在 39% 的家庭成员中。经多变量分析,与患者住在同一屋檐下与 COVID-19 患者家属患精神障碍的风险较低独立相关(OR,0.180;95% CI,0.036-0.908;P = 0.038)。此外,在一年的随访期间,有四名家庭成员克服了精神障碍,有六名家庭成员新近患上了精神障碍:结论:约 40% 的家庭成员长期患有精神障碍,其中一些人在一年的随访中克服了精神障碍,还有一些人新出现了精神障碍。与病人住在同一屋檐下可能与长期精神障碍症状的减少有明显关系,但必须谨慎解释这一结果。还需要进一步开展大型研究,探讨与家庭成员长期精神状况相关的因素。
{"title":"Long-term psychiatric disorders in families of severe COVID-19 patients","authors":"Kasumi Shirasaki,&nbsp;Toru Hifumi,&nbsp;Moe Sekiguchi,&nbsp;Shutaro Isokawa,&nbsp;Yusuke Nakao,&nbsp;Shinobu Tanaka,&nbsp;Shinsuke Hashiuchi,&nbsp;Ryosuke Imai,&nbsp;Norio Otani","doi":"10.1002/ams2.926","DOIUrl":"10.1002/ams2.926","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>The present study aimed to describe in detail the changes to and assess the risk factors for poor long-term outcomes of psychiatric disorders in families of COVID-19 patients.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A single-center, retrospective study using questionnaires. Family members of patients admitted to the intensive care unit (ICU) with severe COVID-19 participated. Psychiatric disorders refer to the psychological distress such as anxiety, depression, and posttraumatic stress disorder (PTSD) experienced by the patient's family.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Forty-six family members completed the survey and were analyzed. Anxiety, depression, and PTSD occurred in 24%, 33%, and 2% of family members, respectively, and psychiatric disorders occurred in 39%. On multivariable analysis, living in the same house with the patient was independently associated with a lower risk of psychiatric disorders in families of COVID-19 patients (OR, 0.180; 95% CI, 0.036–0.908; <i>p</i> = 0.038). Furthermore, four family members overcame psychiatric disorders, and six family members newly developed psychiatric disorders during the one-year follow-up period.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Approximately 40% of family members had long-term psychiatric disorders, and some of them overcame the psychiatric disorders, and some newly developed psychiatric disorders over the one-year follow-up. Living in the same house with the patient was possibly significantly associated with the reduction of long-term symptoms of psychiatric disorders, but this result must be interpreted with care. Further large studies are needed to examine the factors associated with the long-term mental status of family members.</p>\u0000 </section>\u0000 </div>","PeriodicalId":7196,"journal":{"name":"Acute Medicine & Surgery","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10813578/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139568875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A case of multiple organ injury resuscitated by collaboration of damage control surgery and interventional radiology in hybrid emergency room 混合急诊室损伤控制外科和介入放射科合作抢救的一例多器官损伤病例
IF 1.6 Pub Date : 2024-01-15 DOI: 10.1002/ams2.925
Ryosuke Omoto, Yutaka Umemura, Masanari Kato, Yasutaka Nakahori, Satoshi Fujimi

Background

Hybrid emergency room systems, namely hybrid ER (HER), enable us to perform computed tomography (CT), surgery, and interventional radiology (IVR) without patient transfer. HER significantly shortened the time to CT after arrival and allowed us to achieve early intervention, resulting in reduced mortality from exsanguination in patients with severe blunt trauma.

Case Presentation

We encountered a patient diagnosed with left common iliac artery occlusion and dissection caused by blunt traumatic compressive abdominal injury with transection of the small intestine, kidney, and adrenal and pelvic ring fractures. Although the patient experienced cardiopulmonary arrest (CPA) immediately after CT, we performed damage control surgery (DCS) and IVR after temporary aortic occlusion in the HER and resuscitated the patient.

Conclusion

The present case, in which rapid diagnosis and intervention were performed and the patient was successfully resuscitated, supports the efficacy of the HER system for managing severe blunt trauma.

背景 混合急诊室系统,即混合急诊室(HER),使我们能够在不转移病人的情况下进行计算机断层扫描(CT)、手术和介入放射学检查(IVR)。混合急诊室大大缩短了患者到达医院后进行 CT 检查的时间,使我们能够实现早期干预,从而降低了严重钝性创伤患者因失血过多而导致的死亡率。 病例介绍 我们遇到了一位被诊断为左侧髂总动脉闭塞和夹层的患者,其病因是腹部钝性创伤压迫性损伤,并伴有小肠、肾脏和肾上腺横断以及骨盆环骨折。虽然患者在 CT 检查后立即出现心肺停止(CPA),但我们在 HER 中暂时性主动脉闭塞后实施了损伤控制手术(DCS)和 IVR,并抢救了患者。 结论 在本病例中,我们进行了快速诊断和干预,并成功抢救了患者,这证明了 HER 系统在处理严重钝性创伤方面的功效。
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引用次数: 0
Dysbiosis of gut microbiota in patients with severe COVID-19 严重 COVID-19 患者肠道微生物群失调
IF 1.6 Pub Date : 2024-01-10 DOI: 10.1002/ams2.923
Kentaro Shimizu, Haruhiko Hirata, Natsuko Tokuhira, Daisuke Motooka, Shota Nakamura, Akiko Ueda, Jotaro Tachino, Moe Koide, Akinori Uchiyama, Hiroshi Ogura, Jun Oda

Aim

Altered gut microbiota has been proposed as one of the causes of exacerbation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2/COVID-19) from the perspective of the gut–lung axis. We aimed to evaluate gut microbiota in mechanically ventilated patients with COVID-19 prior to using antibiotics.

Methods

We retrospectively selected for enrollment COVID-19 patients who required mechanical ventilation on admission but who had not used antibiotics before admission to observe the influence of SARS-Cov-2 on gut microbiota. Fecal samples were collected serially on admission and were evaluated by 16S rRNA gene deep sequencing.

Results

The phylum of Bacteroidetes decreased, and those of Firmicutes and Actinobacteria increased in COVID-19 patients compared with those in healthy controls (p < 0.001). The main commensals of Bacteroides, Faecalibacterium, and Blautia at the genus level were significantly decreased in the COVID-19 patients, and opportunistic bacteria including Corynebacterium, Anaerococcus, Finegoldia Peptoniphilus, Actinomyces, and Enterococcus were increased (p < 0.001). α-Diversity and β-diversity in COVID-19 patients significantly changed compared with those in the healthy controls.

Conclusion

The commensal gut microbiota were altered, and opportunistic bacteria increased in patients with severe COVID-19 who required mechanical ventilation on admission.

目的 从肠道-肺轴的角度来看,肠道微生物群改变被认为是严重急性呼吸系统综合征冠状病毒 2(SARS-CoV-2/COVID-19)病情加重的原因之一。我们的目的是在使用抗生素之前,评估机械通气患者中 COVID-19 的肠道微生物群。 方法 我们回顾性地选择了入院时需要机械通气但入院前未使用抗生素的 COVID-19 患者作为研究对象,以观察 SARS-Cov-2 对肠道微生物群的影响。入院时连续采集粪便样本,并通过 16S rRNA 基因深度测序进行评估。 结果 与健康对照组相比,COVID-19 患者的类杆菌门减少,而真菌门和放线菌门增加(p <0.001)。在 COVID-19 患者中,主要共生菌 Bacteroides、Faecalibacterium 和 Blautia 的属级数量明显减少,而机会性细菌包括 Corynebacterium、Anaerococcus、Finegoldia Peptoniphilus、Actinomyces 和 Enterococcus 则有所增加(p <0.001)。与健康对照组相比,COVID-19 患者的 α 多样性和 β 多样性发生了显著变化。 结论 在入院时需要机械通气的重症 COVID-19 患者中,共生肠道微生物群发生了改变,机会性细菌增加。
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引用次数: 0
A fatal septic shock caused by Capnocytophaga gingivalis potentially associated with COVID-19: A case report 可能与 COVID-19 相关的牙龈帽状嗜细胞菌引起的致命脓毒性休克:病例报告
IF 1.6 Pub Date : 2024-01-09 DOI: 10.1002/ams2.922
Dai Miyazaki, Chika Kunishige, Shigeru Sano, Kahoru Urakawa, Kana Okamoto, Naomi Morishita, Kentaro Iwata

Background

Capnocytophaga spp. is associated with fulminant sepsis, particularly in those with immunosuppression. We here report a rare case of fatal fulminant septic shock caused by C. gingivalis, concurrent with COVID-19.

Case Presentation

A Japanese woman developed septic shock, which led to her death. Polymerase chain reaction (PCR) testing of the respiratory specimen was positive for SARS-CoV-2, and a CT scan of the chests revealed bilateral ground glass opacities. The blood cultures identified C. gingivalis. The patient had rheumatoid arthritis and was taking prednisone orally. There were no splenic abnormalities shown on the CT scan.

Conclusion

A rare case of fulminant septic shock caused by C. gingivalis, together with COVID-19 was identified. The precise pathogenesis of this combination, together with the best treatment option should be sought by further studies.

背景 噬人牙胞杆菌与暴发性败血症有关,尤其是在免疫抑制患者中。我们在此报告一例罕见的由牙龈噬菌体引起的致命性脓毒性休克病例,该病例同时感染了 COVID-19。 病例介绍 一名日本女性出现脓毒性休克并最终死亡。呼吸道标本的聚合酶链反应(PCR)检测显示 SARS-CoV-2 阳性,胸部 CT 扫描显示双侧磨玻璃不透明。血液培养发现了牙龈球菌。患者患有类风湿性关节炎,正在口服强的松。CT 扫描未发现脾脏异常。 结论 发现了一例罕见的由牙龈裂头蚴和 COVID-19 共同引起的暴发性脓毒性休克病例。应通过进一步的研究来探究这种合并症的确切发病机制以及最佳治疗方案。
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引用次数: 0
Delayed diagnosis of Morel-Lavallee lesion after multiple injuries 多处受伤后莫雷尔-拉瓦列病变的延迟诊断
IF 1.6 Pub Date : 2024-01-07 DOI: 10.1002/ams2.924
Taketomo Soga, Hiroyuki Kakuchi, Hiroshi Toriumi, Takeshi Miura, Moe Oguchi, Mayuko Ikeda, Takafumi Yoshioka, Hikaru Odera, Sei Yano

Morel–Lavallee lesion (MLL) is a post-trauma degloving cyst, usually filled with blood, lymph, or necrotic tissue, which mostly develops in the area around greater trochanter. MLL is associated with the potential risk of infection and progressive expansion of untreated lesions can cause pressure necrosis of overlying skin.1, 2 However, MLL may be missed because it is not visible on the body surface, and the signs of MLL may not be initially apparent. We report a case of delayed diagnosis of MLL after multiple injuries. A 37-year-old man was run over by a truck. Pelvic fractures were detected, and transcatheter arterial embolization and fixation were performed. On the 10th day, delayed sigmoid colon perforation was diagnosed, and emergency surgery was performed. Postoperative hemoglobin level was 10.6 g/dL, but anemia gradually progressed. On day 28, the hemoglobin level was 6.9 g/dL and a blood transfusion was required. In addition, subcutaneous hematoma remained in the left buttock and thigh, and skin necrosis was found on the left buttock and thigh. Therefore, on day 30, plain CT was performed. Plain CT showed an extensive low-density area in the subcutaneous soft tissues of the low lumbar and the left buttocks extending caudally to the left lower thigh and the right greater trochanter (asterisks) (Figure 1A), a finding consistent with a MLL. Needle aspiration was performed, and 1020 mL of old blood was collected from the lesion. However, contrast-enhanced CT on day 47 showed an encapsulated, subcutaneous lesion in the same area (asterisks) (Figure 1B). MRI on day 51 showed an encapsulated, abnormal-intensity lesion in the subcutaneous soft tissues of the low lumbar and the left buttocks extending caudally to the left lower thigh and the right greater trochanter (asterisks). Within this lesion, T1-weighted images appeared isointense to hypointense, and T2-weighted images appeared predominantly hyperintense. MRI coronal STIR shows no fat suppression (Figure 1C). MRI also showed a partial injury to the muscles of the left buttocks (white arrow). In some places within these muscles, T2-weighted images and STIR appeared hyperintense, and T1-weighted images not appeared hyperintense (Figure 1C). Treatment was based on clinical symptoms, lesion size, severity, age, and co-morbidities.1, 2 In this case, surgical excision was performed on day 55 because of the size of the fluid retention. We opened the lesion widely and debrided the interior, and three drainage tubes were inserted. Negative pressure wound therapy was performed thereafter. The wound was healed at 3 months after the trauma. MLL became more marginated as they aged and the chronic lesions were encapsulated. The majority shape of MLL was lenticular and oval, and there was a trend toward an increase in the size of lesion from the acute to the subacute stage and a decrease in size from the subacute to the chronic stage.3

莫雷尔-拉瓦列病变(MLL)是一种创伤后脱落囊肿,通常充满血液、淋巴或坏死组织,主要发生在大转子周围区域。MLL 有潜在的感染风险,未经治疗的病灶逐渐扩大可导致上覆皮肤受压坏死。我们报告了一例多处受伤后延迟诊断 MLL 的病例。一名 37 岁的男子被一辆卡车碾过。发现骨盆骨折后,进行了经导管动脉栓塞和固定。第 10 天,诊断出延迟性乙状结肠穿孔,于是进行了急诊手术。术后血红蛋白水平为 10.6 g/dL,但贫血逐渐加重。第 28 天,血红蛋白水平为 6.9 克/分升,需要输血。此外,左臀部和大腿仍有皮下血肿,左臀部和大腿发现皮肤坏死。因此,在第 30 天进行了普通 CT 检查。平扫 CT 显示,低腰部和左臀部皮下软组织有广泛的低密度区,向尾部延伸至左大腿下部和右大转子(星号)(图 1A),这一结果与 MLL 一致。医生进行了针吸,从病灶处采集到 1020 毫升陈旧血液。然而,第 47 天的对比增强 CT 显示同一部位有一个包裹性皮下病灶(星号)(图 1B)。第 51 天的核磁共振成像显示,在低腰部和左臀部的皮下软组织中有一个包裹性、异常强度的病灶,向尾部延伸至左大腿下部和右大转子(星号)。在该病灶内,T1 加权图像呈等密度至低密度,T2 加权图像主要呈高密度。MRI 冠状 STIR 显示无脂肪抑制(图 1C)。核磁共振成像还显示左臀部肌肉有部分损伤(白色箭头)。在这些肌肉的某些部位,T2 加权图像和 STIR 显示为高密度,而 T1 加权图像未显示为高密度(图 1C)。治疗根据临床症状、病灶大小、严重程度、年龄和合并症而定。1, 2 在本病例中,由于积液较多,我们在第 55 天进行了手术切除。我们大面积切开病灶,对内部进行清创,并插入了三根引流管。之后进行了伤口负压治疗。创伤后 3 个月,伤口愈合。随着年龄的增长,MLL 的边缘变得更加清晰,慢性病灶被包裹。MLL 的形状大多为透镜状和椭圆形,病变大小有从急性期到亚急性期增大、从亚急性期到慢性期缩小的趋势。此外,不仅皮肤和皮下脂肪与下层筋膜平面分离,左臀部肌肉也有部分损伤。高能量创伤会导致更广泛的病变。4 提高对 CT 上 MLL 特征的认识将有助于早期诊断和治疗 MLL,并防止并发症的发生:知情同意:知情同意书:患者同意在本医学刊物上报道与本病例相关的临床信息。研究/试验的注册机构和注册号:不详:动物实验动物研究:不适用。
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引用次数: 0
Future directions of lung-protective ventilation strategies in acute respiratory distress syndrome 急性呼吸窘迫综合征肺保护性通气策略的未来发展方向。
IF 1.6 Pub Date : 2024-01-02 DOI: 10.1002/ams2.918
Taiki Hoshino, Takeshi Yoshida

Acute respiratory distress syndrome (ARDS) is characterized by the heterogeneous distribution of lung aeration along a gravitational direction due to increased lung density. Therefore, the lung available for ventilation is usually limited to ventral, nondependent lung regions and has been called the “baby” lung. In ARDS, ventilator-induced lung injury is known to occur in nondependent “baby” lungs, as ventilation is shifted to ventral, nondependent lung regions, increasing stress and strain. To protect this nondependent “baby” lung, the clinician targets and limits global parameters such as tidal volume and plateau pressure. In addition, positive end-expiratory pressure (PEEP) is used to prevent dorsal, dependent atelectasis and, if successful, increases the size of the baby lung and lessens its susceptibility to injury from inspiratory stretch. Although many clinical trials have been performed in patients with ARDS over the last two decades, there are few successfully showing benefits on mortality (ie, prone positioning and neuromuscular blocking agents). These disappointing results contrast with other medical disciplines, especially in oncology, where the heterogeneity of diseases is recognized widely and precision medicine has been promoted. Thus, lung-protective ventilation strategies need to take an innovative approach that accounts for the heterogeneity of injured lungs. This article summarizes ventilator-induced lung injury and ARDS and discusses how to implement precision medicine in the field of ARDS. Potentially useful methods to individualize PEEP with esophageal balloon manometry, lung recruitability, and electrical impedance tomography were discussed.

急性呼吸窘迫综合征(ARDS)的特点是,由于肺密度增加,肺通气沿重力方向分布不均。因此,可供通气的肺通常仅限于腹侧非依赖性肺区,被称为 "婴儿 "肺。在 ARDS 中,由于通气被转移到腹侧非依赖性肺区,增加了压力和应变,呼吸机诱发的肺损伤已知会发生在非依赖性 "婴儿 "肺中。为了保护这种非依赖性 "婴儿 "肺,临床医生会锁定并限制潮气量和平台压等全局参数。此外,还使用呼气末正压(PEEP)来防止背侧的依赖性无肺活量,如果成功的话,还能增加婴儿肺的大小,降低其因吸气拉伸而受伤的可能性。尽管在过去二十年中对 ARDS 患者进行了许多临床试验,但很少有成功的试验(即俯卧位和神经肌肉阻断剂)显示对死亡率有益处。这些令人失望的结果与其他医学学科形成了鲜明对比,尤其是在肿瘤学领域,疾病的异质性已得到广泛认可,精准医学也得到了推广。因此,肺保护性通气策略需要采取创新方法,考虑到损伤肺的异质性。本文总结了呼吸机诱发的肺损伤和 ARDS,并讨论了如何在 ARDS 领域实施精准医学。文章讨论了利用食管球囊测压、肺招架能力和电阻抗断层扫描对 PEEP 进行个体化的潜在有用方法。
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引用次数: 0
Obstructive azoospermia caused by epididymis injury with testicle rupture on the other side 附睾损伤导致阻塞性无精子症,另一侧睾丸破裂。
IF 1.6 Pub Date : 2023-12-31 DOI: 10.1002/ams2.919
Takayuki Ueda, Masato Yanagi, Akifumi Katsu, Hiroyoshi Kono, Ryoji Kimata, Tsutomu Hamasaki, Yukihiro Kondo

Background

Epididymal injuries without ipsilateral injuries of the testicles are rare. We report a case of a solitary right epididymal injury complicated by left testicular rupture.

Case Presentation

A 21-year-old man experienced scrotal trauma caused by a motorcycle accident. Bilateral swelling and tenderness of the scrotum were observed. Ultrasonography and computed tomography revealed a ruptured left testicle; therefore, surgery was performed. During surgery, the left testicle was excised because it was completely ruptured, and the right testicle and epididymis were evaluated to identify the cause of swelling of the right scrotum. The right testis was not injured; however, the right epididymis was lacerated. Subsequently, the lacerated right epididymis was repaired using sutures. A semen analysis performed at 1, 4, and 7 months after surgery revealed the absence of sperm in the semen.

Conclusion

Epididymal injuries should be considered as differential diagnoses for scrotal trauma.

背景:附睾损伤而没有同侧睾丸损伤的情况非常罕见。我们报告了一例单发右侧附睾损伤并发左侧睾丸破裂的病例:病例介绍:一名 21 岁男子因摩托车事故造成阴囊外伤。观察到双侧阴囊肿胀和触痛。超声波和计算机断层扫描显示左侧睾丸破裂,因此进行了手术。手术中,由于左侧睾丸完全破裂,因此切除了左侧睾丸,并对右侧睾丸和附睾进行了评估,以确定右侧阴囊肿胀的原因。右侧睾丸没有受伤,但右侧附睾被撕裂。随后,使用缝合线修复了撕裂的右侧附睾。术后 1 个月、4 个月和 7 个月的精液分析显示,精液中没有精子:结论:附睾损伤应作为阴囊外伤的鉴别诊断。
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引用次数: 0
Demographic profiles and risk factors for mortality in acute meningitis: A nationwide population-based observational study 急性脑膜炎患者的人口统计学特征和死亡风险因素:一项基于全国人口的观察研究。
IF 1.6 Pub Date : 2023-12-29 DOI: 10.1002/ams2.920
Tetsuya Akaishi, Kunio Tarasawa, Kiyohide Fushimi, Nobuo Yaegashi, Masashi Aoki, Kenji Fujimori

Aim

Acute meningitis encompasses bacterial, viral (aseptic), fungal, tuberculous, and carcinomatous meningitis. The rate and risks of mortality in each type remain uncertain. This study aimed to elucidate these aspects in each type of meningitis.

Methods

This study utilized Japan's nationwide administrative Diagnosis Procedure Combination (DPC) database. Patients with acute meningitis, treated at 1132 DPC-covered hospitals from 2016 to 2022, were enrolled.

Results

Among 47,366,222 cumulative hospitalized patients, 48,758 (0.10%) were hospitalized with acute meningitis. The types of meningitis were as follows: 10,338 with bacterial, 29,486 with viral/aseptic, 965 with fungal, 678 with tuberculous, and 3790 with carcinomatous meningitis. Bacterial and viral meningitis exhibited bimodal age distributions, with the first peak occurring at 0–9 years. The median onset age was below 50 years only in viral meningitis. The mortality rate was the highest in carcinomatous meningitis (39%), followed by fungal meningitis (21%), and the lowest in viral meningitis (0.61%). Mortality rates increased with age across all meningitis types, but this trend was less prominent in carcinomatous meningitis. The duration from admission to mortality was longer in fungal and tuberculous meningitis compared with other types. Staphylococcus aureus in bacterial meningitis (adjusted odds ratio 1.71; p = 0.0016) and herpes simplex virus in viral meningitis (adjusted odds ratio 1.53; p = 0.0467) exhibited elevated mortality rates.

Conclusion

Distinct demographic profiles and mortality rates were observed among different meningitis types. The high mortality rates in less common types of meningitis emphasize the necessity to further optimize the required diagnostic and treatment strategies.

目的:急性脑膜炎包括细菌性、病毒性(无菌性)、真菌性、结核性和癌性脑膜炎。每种类型的死亡率和风险仍不确定。本研究旨在阐明每种脑膜炎的这些方面:本研究利用了日本全国行政诊断程序组合(DPC)数据库。结果:在47366222名急性脑膜炎患者中,有47366222人在DPC数据库中接受了治疗:在 47,366,222 名累计住院患者中,有 48,758 人(0.10%)因急性脑膜炎住院。脑膜炎的类型如下:细菌性脑膜炎 10,338 例,病毒/化脓性脑膜炎 29,486 例,真菌性脑膜炎 965 例,结核性脑膜炎 678 例,癌性脑膜炎 3790 例。细菌性和病毒性脑膜炎的发病年龄呈双峰分布,第一个高峰出现在 0-9 岁。只有病毒性脑膜炎的中位发病年龄低于 50 岁。癌性脑膜炎的死亡率最高(39%),其次是真菌性脑膜炎(21%),病毒性脑膜炎的死亡率最低(0.61%)。在所有脑膜炎类型中,死亡率随年龄增长而增加,但这一趋势在癌性脑膜炎中不太明显。与其他类型的脑膜炎相比,真菌性和结核性脑膜炎从入院到死亡的时间更长。细菌性脑膜炎中的金黄色葡萄球菌(调整后的几率比为1.71;P = 0.0016)和病毒性脑膜炎中的单纯疱疹病毒(调整后的几率比为1.53;P = 0.0467)显示出较高的死亡率:结论:不同类型的脑膜炎有不同的人口统计学特征和死亡率。结论:在不同类型的脑膜炎中观察到了不同的人口统计学特征和死亡率,不常见类型脑膜炎的高死亡率强调了进一步优化所需的诊断和治疗策略的必要性。
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Acute Medicine & Surgery
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