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Impact of COVID-19 on resuscitation after hospital arrival for patients with out-of-hospital cardiac arrest: An interrupted time series analysis COVID-19对院外心脏骤停患者入院后复苏的影响:中断时间序列分析
IF 1.5 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-01-24 DOI: 10.1002/ams2.70039
Takuya Sato, Hiroyuki Ohbe, Yusuke Sasabuchi, Ryota Inokuchi, Hideo Yasunaga, Kent Doi

Background

In this study, we aimed to determine the effects of the coronavirus disease 2019 (COVID-19) pandemic on in-hospital cardiopulmonary resuscitation (CPR) in patients with out-of-hospital cardiac arrest (OHCA).

Methods and Results

Using the Japanese Diagnosis Procedure Combination inpatient database, we included patients with OHCA who were transported to hospitals between April 2018 and March 2021. Patients were categorized into groups, before and during the COVID-19 pandemic, according to the day of admission (before or after April 1, 2020, respectively). The primary outcome was in-hospital CPR duration after hospital arrival, and secondary outcomes included in-hospital death, intubation, and other resuscitation-related treatments. We examined the impact of the pandemic using interrupted time series (ITS) analyses. Among 144,867 patients with OHCA, 82,425 died in the outpatient department (53,286 before the pandemic and 29,139 during the pandemic) during the study period. The ITS analyses for patients who died in the outpatient department showed no significant level change in CPR duration after hospital arrival (0.41 min increase; 95% confidence interval [CI]: −0.54 to 1.4; p = 0.39), but the intubation rate was significantly lower (−5.9%; 95% CI: −8.4 to 3.4; p < 0.001). In-hospital death among all patients with OHCA showed a significant increase in trend (0.41% per month; 95% CI: 0.081–0.74; p = 0.016).

Conclusions

The COVID-19 pandemic had little impact on CPR duration after hospital arrival; however, there was a marked decrease in intubation for patients with OHCA after hospital arrival.

背景:在本研究中,我们旨在确定2019冠状病毒病(COVID-19)大流行对院外心脏骤停(OHCA)患者院内心肺复苏(CPR)的影响。方法和结果:使用日本诊断程序组合住院患者数据库,我们纳入了2018年4月至2021年3月期间送往医院的OHCA患者。根据入院日期(分别为2020年4月1日之前或之后),将患者在COVID-19大流行之前和期间分为两组。主要结局是入院后的院内CPR持续时间,次要结局包括院内死亡、插管和其他与复苏相关的治疗。我们使用中断时间序列(ITS)分析检查了大流行的影响。在研究期间,144867名OHCA患者中,82425人死于门诊(大流行前53286人,大流行期间29139人)。门诊死亡患者的ITS分析显示,到达医院后CPR持续时间无显著变化(增加0.41分钟;95%置信区间[CI]: -0.54 ~ 1.4;P = 0.39),但插管率显著低于对照组(-5.9%;95% CI: -8.4 ~ 3.4;p = 0.016)。结论:2019冠状病毒病疫情对入院后CPR持续时间影响不大;然而,OHCA患者入院后插管率明显下降。
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引用次数: 0
Inadvertent insertion of dialysis catheter into subclavian artery treated with a covered stent: A case report 带膜支架治疗锁骨下动脉透析导管误插入1例。
IF 1.5 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-01-16 DOI: 10.1002/ams2.70038
Yohei Takenobu, Akihiro Furuta, Sumire Haga, Hiroshi Yukawa, Noriko Nomura, Mizuha Toyama, Akihiro Okada, Takeshi Kawauchi, Yukinori Terada, Manabu Inoue, Kenji Hashimoto

Background

When inserting central venous catheters, inadvertent injury of major vessels is a rare yet critical complication. Direct surgery is sometimes overly invasive. This report describes a subclavian artery injury caused by inadvertent cannulation of a dialysis catheter, successfully treated with a covered stent.

Case Presentation

An 82-year-old woman with acute renal failure due to sepsis required emergency dialysis. During the insertion of a 12-Fr dialysis catheter into the right jugular vein, pulsatile reflux was noted. Computed tomography revealed catheter misplacement in the subclavian artery. Considering the patient's fragility, endovascular repair was performed. After embolization of side branches, a GORE VIABAHN stentgraft was delivered using a pull-through technique and deployed to seal the injury site. The patient was discharged without neurological or vascular complications.

Conclusion

Covered stents offer an effective solution for major vessel injuries requiring immediate hemostasis, particularly when direct surgery is complicated by underlying medical or anatomical conditions.

背景:在中心静脉置管时,大血管的意外损伤是一种罕见但重要的并发症。直接手术有时过于侵入性。本报告描述了一个锁骨下动脉损伤引起的疏忽插管透析导管,成功地治疗与覆盖支架。病例介绍:一名82岁妇女因败血症引起的急性肾功能衰竭需要紧急透析。在将12-Fr透析导管插入右颈静脉时,发现搏动性反流。计算机断层扫描显示锁骨下动脉导管错位。考虑到患者的脆弱性,我们进行了血管内修复。侧支栓塞后,采用拉通技术植入GORE VIABAHN支架,并封闭损伤部位。患者出院时无神经或血管并发症。结论:覆盖支架为需要立即止血的大血管损伤提供了有效的解决方案,特别是当直接手术因潜在的医学或解剖条件而合并时。
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引用次数: 0
Crayon ingestion 蜡笔摄入。
IF 1.5 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-01-09 DOI: 10.1002/ams2.70030
Kisho Noda, Tomoki Wada, Ryohei Horie, Toshifumi Asada, Ryota Inokuchi, Kent Doi

A 24-year-old male with autism presented to the emergency department with recurrent vomiting. His mother found crayon fragments in the vomitus. Computed tomography revealed multiple high-density cylindrical objects in the lower esophagus, stomach, and isolated in the ileum (Figure 1A,B). Urgent upper gastrointestinal endoscopy was performed under general anesthesia and 24 crayon fragments were successfully retrieved from the stomach (Figure 1C,D). The crayons in the ileum were defecated without complications.

Although methemoglobinemia induced by colored crayons has been reported previously,1, 2 current crayon formulations consist largely of nontoxic wax with an extremely low risk of acute toxicity. Because crayons are not readily digestible enzymatically or thermally in the gastrointestinal tract owing to a melting point of approximately 60°C, they can readily cause complications such as gastrointestinal obstruction or choking on aspirated vomit. Guidelines for the management of foreign bodies in the stomach recommend urgent removal of sharp or long (≧6 cm in length) objects by urgent endoscopy.3 In this case, the crayon fragments were blunt and <6 cm each, but urgent endoscopy under general anesthesia was performed because the patient with autism was concerned about being unable to express discomfort or pain when complications occurred.

The authors declare no conflicts of interest.

Approval of the research protocol: N/A.

Informed consent: Written informed consent was obtained from the patient's family for the publication of this case report and accompanying images.

Registry and registration no. of the study/trial: N/A.

Animal studies: N/A.

一名24岁男性自闭症患者因反复呕吐到急诊科就诊。他母亲在呕吐物中发现了蜡笔碎片。计算机断层扫描显示食管下部、胃内多发高密度圆柱形物体,回肠内孤立可见(图1A,B)。全麻下进行紧急上消化道内镜检查,成功从胃中取出24块蜡笔碎片(图1C,D)。回肠内的蜡笔全部排出,无并发症。虽然彩色蜡笔引起的高铁血红蛋白血症以前有过报道,但目前的蜡笔配方主要由无毒蜡组成,急性毒性风险极低。由于蜡笔的熔点约为60°C,因此在胃肠道中不易被酶或热消化,因此很容易引起胃肠道阻塞或因吸入呕吐物而窒息等并发症。胃内异物处理指南建议通过紧急内窥镜紧急清除尖锐或长(长度≥6厘米)的物体在这个病例中,蜡笔碎片是钝的,每块6厘米,但由于自闭症患者担心并发症发生时无法表达不适或疼痛,因此在全身麻醉下进行了紧急内窥镜检查。作者声明无利益冲突。研究方案的批准:无。知情同意:本病例报告及随附图片的发表已获得患者家属的书面知情同意。登记处及注册号研究/试验:无。动物研究:无。
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引用次数: 0
Warfarin overdose successfully treated using prophylactic vitamin K infusion without severe coagulopathy: A case report 华法林过量成功治疗预防性维生素K输注无严重凝血功能障碍:1例报告。
IF 1.5 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-01-09 DOI: 10.1002/ams2.70036
Ryosuke Omoto, Yutaka Umemura, Yuki Kokubu, Takeyuki Kiguchi, Satoshi Fujimi

Background

Warfarin, a vitamin K antagonist, is widely used for preventing and treating thromboembolic diseases. While guidelines exist for managing elevated prothrombin time-international normalized ratio (INR) in patients on warfarin, the treatment for warfarin overdose in these patients is yet to be standardized.

Case Presentation

A 41-year-old woman ingested 230 mg of warfarin with suicidal intent, along with other medications. Initially unconscious, her INR was 1.0, and laboratory results were normal. Prophylactic continuous menaquinone-4, vitamin K2, injections were administered before the INR increased. After stopping vitamin K2 72 h later, her INR rose to 1.8, but she recovered without severe coagulopathy or bleeding, despite a high initial warfarin concentration.

Conclusion

This is the first case of warfarin overdose managed with prophylactic vitamin K2 injections before INR elevation, successfully preventing severe complications. Prophylactic vitamin K infusion may be a practical approach for warfarin overdose treatment in non-dependent patients.

背景:华法林是一种维生素K拮抗剂,广泛用于预防和治疗血栓栓塞性疾病。虽然对于华法林患者凝血酶原时间-国际标准化比值(INR)升高的管理指南已经存在,但对于这些患者华法林过量的治疗尚未标准化。病例介绍:一名41岁女性服用了230毫克华法林和其他药物,并有自杀意图。最初无意识,INR为1.0,实验室结果正常。在INR升高前预防性连续注射甲基萘醌-4、维生素K2。停用维生素K2 72小时后,她的INR上升到1.8,尽管华法林初始浓度很高,但她恢复时没有出现严重的凝血功能障碍或出血。结论:这是第一例在INR升高前预防性注射维生素K2治疗华法林过量的病例,成功预防了严重并发症。预防性维生素K输注可能是华法林非依赖患者过量治疗的一种实用方法。
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引用次数: 0
Hypothermia-associated acute pancreatitis: A multicenter prospective observational study 低温相关急性胰腺炎:一项多中心前瞻性观察研究
IF 1.5 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-01-03 DOI: 10.1002/ams2.70033
Masaki Takahashi, Shuhei Takauji, Mineji Hayakawa

Aim

Hypothermia-associated pancreatitis lacks comprehensive understanding owing to limited studies exploring its mechanism, epidemiology, risk factors, and outcomes. We aimed to investigate the frequency, characteristics, and predictive factors associated with the development of acute pancreatitis in patients with accidental hypothermia.

Methods

This study comprised a post hoc analysis of data from a multicenter prospective observational study (ICE-CRASH study) conducted in 36 tertiary emergency hospitals in Japan. Patients aged ≥18 years with core body temperatures ≤32°C admitted to emergency departments between 2019 and 2022 were enrolled. We identified patients who developed acute pancreatitis within 1 week of admission and described their characteristics. Age, vital signs, and blood gas analysis data were analyzed as potential predictors of acute pancreatitis using receiver operating characteristic (ROC) curve analysis.

Results

Of 421 eligible patients with accidental hypothermia, 16 (3.8%) developed acute pancreatitis within 1 week. The age distribution of patients with acute pancreatitis showed bimodal peaks around 50–80 years. Patients with acute pancreatitis had a higher proportion of alcohol consumption than those without acute pancreatitis. ROC curve analysis showed age and pH as significant factors; however, their predictive power was not high.

Conclusion

The incidence of acute pancreatitis was 3.8% in patients with accidental hypothermia with core body temperatures ≤32°C. An association was found between the development of acute pancreatitis and alcohol consumption. No strong predictors of acute pancreatitis were identified.

目的:由于对低温相关性胰腺炎的机制、流行病学、危险因素和结局的研究有限,对其缺乏全面的认识。我们的目的是研究意外低温患者发生急性胰腺炎的频率、特征和预测因素。方法:本研究对日本36家三级急诊医院开展的一项多中心前瞻性观察性研究(ICE-CRASH研究)的数据进行事后分析。纳入2019 - 2022年间急诊科收治的年龄≥18岁、核心体温≤32℃的患者。我们确定了入院1周内发生急性胰腺炎的患者,并描述了他们的特征。采用受试者工作特征(ROC)曲线分析,分析年龄、生命体征和血气分析数据作为急性胰腺炎的潜在预测因素。结果:在421例符合条件的意外低温患者中,16例(3.8%)在1周内发生急性胰腺炎。急性胰腺炎患者的年龄分布在50 ~ 80岁呈双峰型。急性胰腺炎患者饮酒比例高于非急性胰腺炎患者。ROC曲线分析显示年龄和pH值为显著影响因素;然而,他们的预测能力并不高。结论:核心体温≤32℃的意外低温患者急性胰腺炎发生率为3.8%。发现急性胰腺炎的发生与饮酒之间存在关联。没有发现急性胰腺炎的强预测因子。
{"title":"Hypothermia-associated acute pancreatitis: A multicenter prospective observational study","authors":"Masaki Takahashi,&nbsp;Shuhei Takauji,&nbsp;Mineji Hayakawa","doi":"10.1002/ams2.70033","DOIUrl":"10.1002/ams2.70033","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>Hypothermia-associated pancreatitis lacks comprehensive understanding owing to limited studies exploring its mechanism, epidemiology, risk factors, and outcomes. We aimed to investigate the frequency, characteristics, and predictive factors associated with the development of acute pancreatitis in patients with accidental hypothermia.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This study comprised a post hoc analysis of data from a multicenter prospective observational study (ICE-CRASH study) conducted in 36 tertiary emergency hospitals in Japan. Patients aged ≥18 years with core body temperatures ≤32°C admitted to emergency departments between 2019 and 2022 were enrolled. We identified patients who developed acute pancreatitis within 1 week of admission and described their characteristics. Age, vital signs, and blood gas analysis data were analyzed as potential predictors of acute pancreatitis using receiver operating characteristic (ROC) curve analysis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Of 421 eligible patients with accidental hypothermia, 16 (3.8%) developed acute pancreatitis within 1 week. The age distribution of patients with acute pancreatitis showed bimodal peaks around 50–80 years. Patients with acute pancreatitis had a higher proportion of alcohol consumption than those without acute pancreatitis. ROC curve analysis showed age and pH as significant factors; however, their predictive power was not high.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The incidence of acute pancreatitis was 3.8% in patients with accidental hypothermia with core body temperatures ≤32°C. An association was found between the development of acute pancreatitis and alcohol consumption. No strong predictors of acute pancreatitis were identified.</p>\u0000 </section>\u0000 </div>","PeriodicalId":7196,"journal":{"name":"Acute Medicine & Surgery","volume":"12 1","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11702497/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142942490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characteristics and outcomes of subarachnoid hemorrhage from vertebral artery dissection: A comparative study with other non-traumatic etiologies 椎动脉夹层引起的蛛网膜下腔出血的特点和结局:与其他非创伤性病因的比较研究。
IF 1.5 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-12-26 DOI: 10.1002/ams2.70031
Shu Oshita, Tetsuya Yumoto, Shunta Jinno, Ippei Matsuo, Takashi Hongo, Hiromichi Naito, Masafumi Hiramatsu, Jun Haruma, Kenji Sugiu, Shota Tanaka, Atsunori Nakao

Aim

Vertebral artery dissection (VAD) is a rare cause of non-traumatic subarachnoid hemorrhage (SAH) with significant clinical implications. This study compared the clinical characteristics and outcomes of SAH from intracranial VAD rupture to those from other etiologies, primarily aneurysmal rupture.

Methods

This single-center retrospective cohort study at Okayama University Hospital included patients with non-traumatic SAH diagnosed between 2019 and 2023. Patients were categorized into “VAD rupture” and “other etiologies” groups. The main outcome was clinical presentation and symptoms. Additional outcomes included ICU mortality, in-hospital mortality, and unfavorable outcomes at discharge and 6 months, defined as a modified Rankin Scale score of 3–6.

Results

A total of 66 patients were included, with 14 in the VAD rupture group and 52 in the other etiologies group. The VAD rupture group was younger (median age 49 vs. 64 years, p = 0.003) and had a higher incidence of out-of-hospital cardiac arrest (42.9% vs. 9.6%, p = 0.011). Preceding headache was more common in the VAD rupture group (78.6% vs. 11.5%, p < 0.001), with a median duration of 36 h before presentation. ICU and in-hospital mortality was higher in the VAD rupture group (both 50.0% vs. 19.3%, p = 0.019). No significant differences were found in unfavorable neurological outcomes at hospital discharge and 6 months.

Conclusions

VAD-related SAH often presents with prodromal headaches, severe symptoms like out-of-hospital cardiac arrest, and higher ICU and in-hospital mortality than other SAH causes, though long-term outcomes are similar. Larger, prospective studies are needed to refine interventions.

目的:椎动脉夹层(VAD)是一种罕见的非外伤性蛛网膜下腔出血(SAH)的原因,具有重要的临床意义。本研究比较了颅内VAD破裂与其他原因(主要是动脉瘤破裂)引起的SAH的临床特征和结果。方法:冈山大学医院的单中心回顾性队列研究纳入了2019年至2023年间诊断的非创伤性SAH患者。患者分为“VAD破裂”组和“其他病因”组。主要结局是临床表现和症状。其他结局包括ICU死亡率、住院死亡率、出院和6个月时的不良结局,定义为修改后的Rankin量表得分为3-6。结果:共纳入66例患者,其中VAD破裂组14例,其他病因组52例。VAD破裂组更年轻(中位年龄49比64岁,p = 0.003),院外心脏骤停发生率更高(42.9%比9.6%,p = 0.011)。VAD破裂组先前的头痛更常见(78.6%比11.5%,p p = 0.019)。出院时和6个月时的不良神经预后无显著差异。结论:与vad相关的SAH通常表现为前体头痛,院外心脏骤停等严重症状,ICU和住院死亡率高于其他SAH原因,尽管长期结局相似。需要更大规模的前瞻性研究来完善干预措施。
{"title":"Characteristics and outcomes of subarachnoid hemorrhage from vertebral artery dissection: A comparative study with other non-traumatic etiologies","authors":"Shu Oshita,&nbsp;Tetsuya Yumoto,&nbsp;Shunta Jinno,&nbsp;Ippei Matsuo,&nbsp;Takashi Hongo,&nbsp;Hiromichi Naito,&nbsp;Masafumi Hiramatsu,&nbsp;Jun Haruma,&nbsp;Kenji Sugiu,&nbsp;Shota Tanaka,&nbsp;Atsunori Nakao","doi":"10.1002/ams2.70031","DOIUrl":"10.1002/ams2.70031","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>Vertebral artery dissection (VAD) is a rare cause of non-traumatic subarachnoid hemorrhage (SAH) with significant clinical implications. This study compared the clinical characteristics and outcomes of SAH from intracranial VAD rupture to those from other etiologies, primarily aneurysmal rupture.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This single-center retrospective cohort study at Okayama University Hospital included patients with non-traumatic SAH diagnosed between 2019 and 2023. Patients were categorized into “VAD rupture” and “other etiologies” groups. The main outcome was clinical presentation and symptoms. Additional outcomes included ICU mortality, in-hospital mortality, and unfavorable outcomes at discharge and 6 months, defined as a modified Rankin Scale score of 3–6.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 66 patients were included, with 14 in the VAD rupture group and 52 in the other etiologies group. The VAD rupture group was younger (median age 49 vs. 64 years, <i>p</i> = 0.003) and had a higher incidence of out-of-hospital cardiac arrest (42.9% vs. 9.6%, <i>p</i> = 0.011). Preceding headache was more common in the VAD rupture group (78.6% vs. 11.5%, <i>p</i> &lt; 0.001), with a median duration of 36 h before presentation. ICU and in-hospital mortality was higher in the VAD rupture group (both 50.0% vs. 19.3%, <i>p</i> = 0.019). No significant differences were found in unfavorable neurological outcomes at hospital discharge and 6 months.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>VAD-related SAH often presents with prodromal headaches, severe symptoms like out-of-hospital cardiac arrest, and higher ICU and in-hospital mortality than other SAH causes, though long-term outcomes are similar. Larger, prospective studies are needed to refine interventions.</p>\u0000 </section>\u0000 </div>","PeriodicalId":7196,"journal":{"name":"Acute Medicine & Surgery","volume":"11 1","pages":""},"PeriodicalIF":1.5,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11671172/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142891336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Letter to “Early do-not-attempt resuscitation orders and neurological outcomes in older out-of-hospital cardiac arrest patient: A multicenter observational study” 致“老年院外心脏骤停患者早期不尝试复苏指令与神经系统预后:一项多中心观察性研究”的信。
IF 1.5 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-12-25 DOI: 10.1002/ams2.70029
Benjamin Tangkamolsuk, Quang La, David F. Lo

We enjoyed reading the article by Kohri et al., titled “Early do-not-attempt resuscitation orders and neurological outcomes in older out-of-hospital cardiac arrest patients: A multicenter observational study” and would like to offer additional commentary on the article.1 We hope these perspectives may provide insight into areas that may require further research and improvement.

Kohri et al. reported on the association between early DNR orders and neurological outcomes in OHCA patients, highlighting any possible trends between early DNR orders and OHCA patients. They found that those with a DNR order placed received less therapeutic care intervention and had worse neurological outcomes after the same time period, compared to non-DNR patient counterparts. The paper calls for the reconsideration of the implementation of DNR shortly after cardiac arrest in acute care settings.

Kohri et al. had studied the DNR orders and their associated outcomes; however, it lacks the comprehensive assessment of the patient's symptoms leading to the DNR orders, which presents several limitations in the observational study. As a result of this, the conclusion may be misleading as the DNR decision-making may have been impacted by other factors, such as pain management.2

Although the article has a limited level of balancing and confounding through elements such as propensity score analysis, it does not account for subjectivity and biases on the personal level. The clinical judgment or personal biases may vary from individual to individual, and different institutions and hospitals may have their own policies and clinical expertise, resulting in a reduction in the robustness of the conclusion.3

Lastly, the methodology used in the article is quite simplistic and does not capture the overwhelmingly complex reality of healthcare, in which there are a number of different variables that could affect it, such as religion, belief, or socio-economic factors of the family outside the clinical field.4

Ultimately, this paper presents a timely and relevant investigation into the correlation between DNR decisions and the neurological outcomes of OHCA patients. By addressing these issues, we can help strengthen the conclusions of essential studies used to improve healthcare globally. We applaud the authors for not only emphasizing the importance of the stress of issuing DNR orders early into care inside an acute care setting. We look forward to reading about future studies that provide insight into these factors.

No funding was received for this study/paper.

The authors declare no conflicts of interest.

Approval of the research protocol: N/A.

Informed consent: N/A.

Registry and the registration no. of the study/trial: N/A.

Animal studies: N/A.

我们喜欢阅读Kohri等人的文章,题为“早期不尝试复苏命令和老年院外心脏骤停患者的神经预后:一项多中心观察性研究”,并希望对该文章提供额外的评论我们希望这些观点可以为需要进一步研究和改进的领域提供见解。Kohri等人报道了早期DNR命令与OHCA患者神经预后之间的关系,强调了早期DNR命令与OHCA患者之间的任何可能趋势。他们发现,与非DNR患者相比,那些接受DNR订单的患者在同一时间段内接受的治疗护理干预较少,神经系统预后更差。本文呼吁重新考虑在急性护理环境中心脏骤停后不久实施DNR。Kohri等人研究了DNR顺序及其相关结果;然而,它缺乏对导致DNR命令的患者症状的全面评估,这在观察性研究中存在一些局限性。因此,结论可能具有误导性,因为DNR决策可能受到其他因素的影响,例如疼痛管理。虽然这篇文章通过倾向得分分析等因素有一定程度的平衡和混淆,但它没有考虑到个人层面的主观性和偏见。临床判断或个人偏见可能因人而异,不同的机构和医院可能有自己的政策和临床专业知识,导致结论的稳健性降低。最后,文章中使用的方法非常简单,没有捕捉到医疗保健的压倒性复杂现实,其中有许多不同的变量可能会影响它,例如宗教,信仰或临床领域之外的家庭社会经济因素。最后,本文提出了一项及时和相关的研究,探讨了DNR决策与OHCA患者神经预后之间的相关性。通过解决这些问题,我们可以帮助加强用于改善全球医疗保健的基本研究的结论。我们赞赏作者不仅强调了在急性护理环境中早期发布DNR命令的压力的重要性。我们期待未来的研究能够深入了解这些因素。本研究/论文没有收到资助。作者声明无利益冲突。研究方案的批准:无。知情同意:无。注册表及注册编号研究/试验:无。动物研究:无。
{"title":"Letter to “Early do-not-attempt resuscitation orders and neurological outcomes in older out-of-hospital cardiac arrest patient: A multicenter observational study”","authors":"Benjamin Tangkamolsuk,&nbsp;Quang La,&nbsp;David F. Lo","doi":"10.1002/ams2.70029","DOIUrl":"10.1002/ams2.70029","url":null,"abstract":"<p>We enjoyed reading the article by Kohri et al., titled “Early do-not-attempt resuscitation orders and neurological outcomes in older out-of-hospital cardiac arrest patients: A multicenter observational study” and would like to offer additional commentary on the article.<span><sup>1</sup></span> We hope these perspectives may provide insight into areas that may require further research and improvement.</p><p>Kohri et al. reported on the association between early DNR orders and neurological outcomes in OHCA patients, highlighting any possible trends between early DNR orders and OHCA patients. They found that those with a DNR order placed received less therapeutic care intervention and had worse neurological outcomes after the same time period, compared to non-DNR patient counterparts. The paper calls for the reconsideration of the implementation of DNR shortly after cardiac arrest in acute care settings.</p><p>Kohri et al. had studied the DNR orders and their associated outcomes; however, it lacks the comprehensive assessment of the patient's symptoms leading to the DNR orders, which presents several limitations in the observational study. As a result of this, the conclusion may be misleading as the DNR decision-making may have been impacted by other factors, such as pain management.<span><sup>2</sup></span></p><p>Although the article has a limited level of balancing and confounding through elements such as propensity score analysis, it does not account for subjectivity and biases on the personal level. The clinical judgment or personal biases may vary from individual to individual, and different institutions and hospitals may have their own policies and clinical expertise, resulting in a reduction in the robustness of the conclusion.<span><sup>3</sup></span></p><p>Lastly, the methodology used in the article is quite simplistic and does not capture the overwhelmingly complex reality of healthcare, in which there are a number of different variables that could affect it, such as religion, belief, or socio-economic factors of the family outside the clinical field.<span><sup>4</sup></span></p><p>Ultimately, this paper presents a timely and relevant investigation into the correlation between DNR decisions and the neurological outcomes of OHCA patients. By addressing these issues, we can help strengthen the conclusions of essential studies used to improve healthcare globally. We applaud the authors for not only emphasizing the importance of the stress of issuing DNR orders early into care inside an acute care setting. We look forward to reading about future studies that provide insight into these factors.</p><p>No funding was received for this study/paper.</p><p>The authors declare no conflicts of interest.</p><p>Approval of the research protocol: N/A.</p><p>Informed consent: N/A.</p><p>Registry and the registration no. of the study/trial: N/A.</p><p>Animal studies: N/A.</p>","PeriodicalId":7196,"journal":{"name":"Acute Medicine & Surgery","volume":"11 1","pages":""},"PeriodicalIF":1.5,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11669746/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142891338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association between PaCO2 and outcomes in patients who underwent extracorporeal cardiopulmonary resuscitation for out-of-hospital cardiac arrest 院外心脏骤停患者接受体外心肺复苏后PaCO2与预后的关系
IF 1.5 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-12-20 DOI: 10.1002/ams2.70021
Ayumi Kawakami, Keita Shibahashi, Kazuhiro Sugiyama, Toru Hifumi, Akihiko Inoue, Tetsuya Sakamoto, Yasuhiro Kuroda, the SAVE-J II Study Group

Aim

The optimal arterial partial pressure of carbon dioxide (PaCO2) for patients undergoing extracorporeal cardiopulmonary resuscitation (ECPR) remains unknown. We aimed to investigate the association between post-resuscitation PaCO2 and neurological outcomes.

Methods

This retrospective cohort study analyzed data from the Study of Advanced Life Support for Ventricular Fibrillation with Extracorporeal Circulation in Japan, a multicenter registry study across 36 hospitals in Japan, including patients with out-of-hospital cardiac arrest (OHCA) admitted to intensive care units (ICU) after ECPR between 2013 and 2018. Good PaCO2 management status was defined as a PaCO2 value of 35–45 mmHg. We classified patients into four groups (poor–poor, poor–good, good–poor, and good–good) according to their PaCO2 management status upon admission at the ICU and the following day. The primary outcome was a favorable neurological outcome, defined as cerebral performance category 1 or 2, 30 days after cardiac arrest. The secondary outcome was survival 30 days after cardiac arrest.

Results

We classified 885 eligible patients into poor–poor (n = 361), poor–good (n = 231), good–poor (n = 155), and good–good (n = 138) groups. No significant association was observed between PaCO2 management and favorable 30-day neurological outcomes. Compared with the poor–poor group, the poor–good, good–poor, and good–good groups had adjusted odds ratios of 0.87 (95% confidence interval, 0.52–1.44), 1.17 (0.65–2.05), and 0.95 (0.51–1.73), respectively. The 30-day survival rates among the four groups did not differ significantly.

Conclusion

PaCO2 values were not significantly associated with 30-day neurological outcomes or survival of patients with OHCA after ECPR.

目的体外心肺复苏(ECPR)患者的最佳动脉血二氧化碳分压(PaCO2)尚不明确。我们的目的是研究复苏后PaCO2与神经预后之间的关系。本回顾性队列研究分析了日本室性颤动体外循环高级生命支持研究的数据,这是一项在日本36家医院进行的多中心注册研究,包括2013年至2018年间在ECPR后入住重症监护病房(ICU)的院外心脏骤停(OHCA)患者。PaCO2管理良好定义为PaCO2值在35 ~ 45mmhg之间。根据患者入院时及次日PaCO2管理情况将患者分为差-差、差-好、好-差、好-好4组。主要结果是良好的神经学结果,定义为心脏骤停后30天的大脑表现1或2类。次要终点是心脏骤停后30天的生存。结果885例符合条件的患者分为差-差(n = 361)、差-好(n = 231)、好-差(n = 155)和好-好(n = 138)组。PaCO2管理与良好的30天神经预后之间无显著关联。与穷-穷组相比,穷-好、好-差和好-好组的调整优势比分别为0.87(95%可信区间0.52-1.44)、1.17(0.65-2.05)和0.95(0.51-1.73)。四组间30天生存率无显著差异。结论PaCO2值与ECPR后OHCA患者30天神经预后或生存无显著相关性。
{"title":"Association between PaCO2 and outcomes in patients who underwent extracorporeal cardiopulmonary resuscitation for out-of-hospital cardiac arrest","authors":"Ayumi Kawakami,&nbsp;Keita Shibahashi,&nbsp;Kazuhiro Sugiyama,&nbsp;Toru Hifumi,&nbsp;Akihiko Inoue,&nbsp;Tetsuya Sakamoto,&nbsp;Yasuhiro Kuroda,&nbsp;the SAVE-J II Study Group","doi":"10.1002/ams2.70021","DOIUrl":"https://doi.org/10.1002/ams2.70021","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>The optimal arterial partial pressure of carbon dioxide (PaCO<sub>2</sub>) for patients undergoing extracorporeal cardiopulmonary resuscitation (ECPR) remains unknown. We aimed to investigate the association between post-resuscitation PaCO<sub>2</sub> and neurological outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This retrospective cohort study analyzed data from the Study of Advanced Life Support for Ventricular Fibrillation with Extracorporeal Circulation in Japan, a multicenter registry study across 36 hospitals in Japan, including patients with out-of-hospital cardiac arrest (OHCA) admitted to intensive care units (ICU) after ECPR between 2013 and 2018. Good PaCO<sub>2</sub> management status was defined as a PaCO<sub>2</sub> value of 35–45 mmHg. We classified patients into four groups (poor–poor, poor–good, good–poor, and good–good) according to their PaCO<sub>2</sub> management status upon admission at the ICU and the following day. The primary outcome was a favorable neurological outcome, defined as cerebral performance category 1 or 2, 30 days after cardiac arrest. The secondary outcome was survival 30 days after cardiac arrest.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>We classified 885 eligible patients into poor–poor (<i>n</i> = 361), poor–good (<i>n</i> = 231), good–poor (<i>n</i> = 155), and good–good (<i>n</i> = 138) groups. No significant association was observed between PaCO<sub>2</sub> management and favorable 30-day neurological outcomes. Compared with the poor–poor group, the poor–good, good–poor, and good–good groups had adjusted odds ratios of 0.87 (95% confidence interval, 0.52–1.44), 1.17 (0.65–2.05), and 0.95 (0.51–1.73), respectively. The 30-day survival rates among the four groups did not differ significantly.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>PaCO<sub>2</sub> values were not significantly associated with 30-day neurological outcomes or survival of patients with OHCA after ECPR.</p>\u0000 </section>\u0000 </div>","PeriodicalId":7196,"journal":{"name":"Acute Medicine & Surgery","volume":"11 1","pages":""},"PeriodicalIF":1.5,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ams2.70021","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142861877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
External validation of the sICOP score for early mortality in mechanically ventilated patients with COVID-19 COVID-19机械通气患者早期死亡率sICOP评分的外部验证
IF 1.5 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-12-09 DOI: 10.1002/ams2.978
Mitsuaki Nishikimi, Kei Hayashida, Takashi Tagami, Shinichiro Ohshimo, Nobuaki Shime, Kazuma Yamakawa

Background and Objectives

The aim of this study was to externally validate the prognostic score for mechanically ventilated patients with novel coronavirus disease-2019 (COVID-19), the simplified intubated COVID-19 predictive (sICOP) score.

Methods

This was a retrospective, multicenter, observational study conducted using the database registry of patients with moderate-to-severe COVID-19 at 66 hospitals in Japan. The data of 146 mechanically ventilated COVID-19 patients were analyzed.

Results

The areas under the curve (AUC) of the sICOP score for predicting the 28-day mortality and in-hospital mortality were 0.81 (0.73–0.89) and 0.74 (0.65–0.83), respectively. The AUC of the score was statistically significantly higher than that of the SOFA score for 28-day mortality and in-hospital mortality (28-day mortality; 0.82 [0.73–0.90] vs. 0.58 [0.46–0.70], p < 0.001, in-hospital mortality; 0.75 [0.66–0.84] vs 0.55 [0.44–0.66], p < 0.001).

Conclusion

We found that the sICOP score was useful for predicting the 28-day mortality with excellent accuracy in mechanically ventilated COVID-19 patients in the era prior to the widespread availability of vaccines and effective antivirals. Validation of the score would be needed by using data from recent waves.

背景与目的:本研究的目的是外部验证机械通气的新型冠状病毒病-2019 (COVID-19)患者预后评分,即简化的插管COVID-19预测(sICOP)评分。方法:这是一项回顾性、多中心、观察性研究,使用日本66家医院的中重度COVID-19患者数据库登记。对146例机械通气COVID-19患者的资料进行分析。结果:sICOP评分预测28天死亡率和住院死亡率的曲线下面积(AUC)分别为0.81(0.73 ~ 0.89)和0.74(0.65 ~ 0.83)。该评分的AUC在28天死亡率和住院死亡率方面均显著高于SOFA评分(28天死亡率;结论:我们发现在疫苗和有效抗病毒药物广泛使用之前,sICOP评分可用于预测机械通气的COVID-19患者28天死亡率,准确性很高。需要使用最近几波的数据来验证分数。
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引用次数: 0
A case of lung injury due to a hydrogen explosion caused by the simultaneous use of two home folk remedies devices 同时使用两种家庭偏方装置导致氢气爆炸致肺损伤一例
IF 1.5 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-12-03 DOI: 10.1002/ams2.70019
Masato Tsuchikane, Takeshi Yamagiwa, Tadaaki Takada, Shinjiro Wakai, Sadaki Inokuchi

A 62-year-old woman was diagnosed with postoperative breast cancer recurrence. While inhaling hydrogen gas through a nasal cannula at home, she used a heat-therapy machine that emitted electromagnetic waves to the breast cancer site. She suddenly experienced explosive sounds in her chest and smelled burning. Subsequently, she experienced several overlapping hemoptysis episodes and was referred to our hospital for further evaluation. Computed tomography revealed an alveolar-centered pulmonary contusion (Figure 1), and the patient was admitted to the hospital with a diagnosis of inhalation combustion lung injury. Arterial blood gas analysis showed no deterioration, and computed tomography revealed no worsening of pulmonary findings or oxygen demand. The hemoptysis resolved spontaneously, and re-evaluation on day 9 confirmed the disappearance of the pulmonary contusion.

Blast lung injuries typically occur during wars or bombing incidents but rarely occur in the home environment.1 Although the medical efficacy of hydrogen gas remains controversial, several studies have reported the risk of associated explosions.2 Our patient was exposed to a small explosion that caused no abnormalities in blood test results, including coagulation function parameters. This case demonstrates that lung injuries caused by the inhalation of combustible gases associated with folk remedies can occur even at home.

The authors declare no conflicts of interest.

Approval of the research protocol: N/A.

Informed consent: Informed consent was obtained from the patient.

Registry and registration no. of the study/trial: N/A.

Animal studies: N/A.

一位62岁的女性被诊断为乳腺癌术后复发。在家里通过鼻插管吸入氢气的同时,她使用了一种向乳腺癌部位发射电磁波的热疗机。她突然感到胸口有爆炸声,还闻到了烧焦的味道。随后,她经历了几次重叠的咯血发作,并被转到我们医院进一步评估。计算机断层扫描显示肺泡中心型肺挫伤(图1),患者被诊断为吸入性燃烧性肺损伤入院。动脉血气分析显示没有恶化,计算机断层扫描显示肺部表现或需氧量没有恶化。咯血自然消退,第9天复查证实肺挫伤消失。爆炸性肺损伤通常发生在战争或轰炸事件中,但很少发生在家庭环境中尽管氢气的医疗功效仍有争议,但几项研究报告了相关爆炸的危险我们的病人暴露在一个小爆炸中,没有引起血液检查结果的异常,包括凝血功能参数。这个案例表明,即使在家中也可能发生由吸入与民间疗法相关的可燃气体引起的肺损伤。作者声明无利益冲突。研究方案的批准:无。知情同意:获得患者的知情同意。登记处及注册号研究/试验:无。动物研究:无。
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引用次数: 0
期刊
Acute Medicine & Surgery
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