Diabetic retinopathy (DR) stands out as one of the most significant causes of treatable visual impairment and blindness worldwide. Hence, early detection coupled with timely intervention is crucial to prevent the disease from further progression. However, manually detecting DR through the use of retinal images is highly time-consuming, subjective, and often inaccessible in resource-limited settings. This research introduces a groundbreaking automated system for DR detection and severity classification. First, we collected the corresponding data and applied advanced preprocessing techniques such as resizing image, normalization, Gaussian blur, contrast limited adaptive histogram equalization (CLAHE), and image blending to improve model performance. Furthermore, we employed powerful deep learning (DL) architectures such as VGG, EfficientNet, DenseNet, ResNet50, and transformer models such as vision transformer (ViT), and swin transformer for feature extraction. The resulting features were then classified using robust machine learning algorithms, ensemble models, CNN models, and transformer-based models, including decision tree (DT), K-nearest neighbor (KNN), logistic regression (LR), support vector machine (SVM), random forest (RF), AdaBoost, and XGBoost, VGG, EfficientNet, DenseNet, ResNet50, vision transformer, swin transformer, and proposed a new hybrid technique that integrates KNN with random forest (KNN-RF). We tested the system with the appropriate key metrics: accuracy, precision, recall, and F1-score. Our findings show that the hybrid KNN-RF technique outperforms the others. Results point to promising possibilities for our approach in providing precise, scalable, and cost-effective diabetic retinopathy diagnoses in resource-scarce settings. This study emphasizes the importance of artificial intelligence in revolutionizing healthcare diagnostic processes and tackling essential global health issues.
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