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A combined voting mechanism in KNN and random forest algorithms to enhance the diabetic retinopathy eye disease detection 一种结合KNN和随机森林算法的投票机制来增强糖尿病视网膜病变眼病的检测
Pub Date : 2026-01-22 DOI: 10.1007/s43674-025-00086-w
J. Vijaya, B. Sai Vikas, J. Jaya Surya, K. Nitheesh Kumar, B. Shriya

Diabetic retinopathy (DR) stands out as one of the most significant causes of treatable visual impairment and blindness worldwide. Hence, early detection coupled with timely intervention is crucial to prevent the disease from further progression. However, manually detecting DR through the use of retinal images is highly time-consuming, subjective, and often inaccessible in resource-limited settings. This research introduces a groundbreaking automated system for DR detection and severity classification. First, we collected the corresponding data and applied advanced preprocessing techniques such as resizing image, normalization, Gaussian blur, contrast limited adaptive histogram equalization (CLAHE), and image blending to improve model performance. Furthermore, we employed powerful deep learning (DL) architectures such as VGG, EfficientNet, DenseNet, ResNet50, and transformer models such as vision transformer (ViT), and swin transformer for feature extraction. The resulting features were then classified using robust machine learning algorithms, ensemble models, CNN models, and transformer-based models, including decision tree (DT), K-nearest neighbor (KNN), logistic regression (LR), support vector machine (SVM), random forest (RF), AdaBoost, and XGBoost, VGG, EfficientNet, DenseNet, ResNet50, vision transformer, swin transformer, and proposed a new hybrid technique that integrates KNN with random forest (KNN-RF). We tested the system with the appropriate key metrics: accuracy, precision, recall, and F1-score. Our findings show that the hybrid KNN-RF technique outperforms the others. Results point to promising possibilities for our approach in providing precise, scalable, and cost-effective diabetic retinopathy diagnoses in resource-scarce settings. This study emphasizes the importance of artificial intelligence in revolutionizing healthcare diagnostic processes and tackling essential global health issues.

糖尿病视网膜病变(DR)是世界范围内可治疗的视力障碍和失明的最重要原因之一。因此,早期发现和及时干预对于防止疾病进一步发展至关重要。然而,通过使用视网膜图像来手动检测DR是非常耗时、主观的,而且在资源有限的情况下往往无法实现。本研究介绍了一种突破性的DR检测和严重性分类自动化系统。首先,我们收集了相应的数据,并采用了调整图像大小、归一化、高斯模糊、对比度有限自适应直方图均衡化(CLAHE)和图像混合等先进的预处理技术来提高模型的性能。此外,我们采用了强大的深度学习(DL)架构,如VGG、EfficientNet、DenseNet、ResNet50,以及变压器模型,如vision transformer (ViT)和swin transformer进行特征提取。然后使用鲁棒机器学习算法、集成模型、CNN模型和基于变压器的模型,包括决策树(DT)、k近邻(KNN)、逻辑回归(LR)、支持向量机(SVM)、随机森林(RF)、AdaBoost、XGBoost、VGG、EfficientNet、DenseNet、ResNet50、视觉变压器、swin变压器,对得到的特征进行分类,并提出了一种将KNN与随机森林(KNN-RF)相结合的新混合技术。我们用适当的关键指标对系统进行了测试:准确性、精确度、召回率和f1分数。我们的研究结果表明,混合KNN-RF技术优于其他技术。结果表明,我们的方法有希望在资源稀缺的环境中提供精确、可扩展和具有成本效益的糖尿病视网膜病变诊断。这项研究强调了人工智能在革命性医疗诊断过程和解决基本全球健康问题中的重要性。
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引用次数: 0
Construction of new transfer functions and their application in solving knapsack problems with discrete Kepler optimization algorithm 新的传递函数的构造及其在离散Kepler优化算法求解背包问题中的应用
Pub Date : 2025-11-15 DOI: 10.1007/s43674-025-00085-x
Yichao He, Guoxin Chen, Ju Chen, Manman Meng

Transfer function plays a crucial role in discretizing metaheuristic algorithms to solve combinatorial optimization problems. However, existing transfer functions not only have few classes, but their design methods also rely too much on the curve shape. Kepler optimization algorithm (KOA) is a novel metaheuristic algorithm that performs well in solving optimization problems on continuous domains, but cannot be directly applied to solve combinatorial optimization problems on discrete domains. In order to design more transfer functions and solve combinatorial optimization problems by KOA, this paper first proposes a practical method to construct transfer functions. From this, two new classes of transfer functions are given: A-shaped transfer functions and B-shaped transfer functions. Then, based on the transfer function, the first discrete Kepler optimization algorithm (DKOA) suitable for binary optimization problems is proposed. To verify the practicality of the new transfer functions and the efficiency of DKOA, DKOA is used to solve 0–1 knapsack problem and knapsack problem with a single continuous variable, respectively. Comparison with existing transfer functions and the state-of-the-art metaheuristic algorithms for solving these two problems shows that DKOA using A-shaped and B-shaped transfer functions is more competitive in terms of the ability to obtain optimal solutions, average performance and stability. This shows that the proposed new transfer functions are very practical, and the DKOA based on them is an effective metaheuristic algorithm for solving binary optimization problems.

传递函数在求解组合优化问题的离散化元启发式算法中起着至关重要的作用。然而,现有的传递函数不仅类少,而且其设计方法也过于依赖于曲线形状。开普勒优化算法(Kepler optimization algorithm, KOA)是一种新型的元启发式算法,它能很好地解决连续域上的优化问题,但不能直接应用于解决离散域上的组合优化问题。为了设计更多的传递函数,利用KOA求解组合优化问题,本文首先提出了一种实用的构造传递函数的方法。由此,给出了两类新的传递函数:a型传递函数和b型传递函数。然后,基于传递函数,提出了适用于二元优化问题的离散Kepler优化算法(DKOA)。为了验证新传递函数的实用性和DKOA的有效性,分别用DKOA求解0-1背包问题和单连续变量背包问题。与现有的传递函数和最先进的用于解决这两个问题的元启发式算法相比,使用a形和b形传递函数的DKOA在获得最优解的能力、平均性能和稳定性方面更具竞争力。这表明所提出的新传递函数是非常实用的,基于它们的DKOA是解决二元优化问题的一种有效的元启发式算法。
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引用次数: 0
Forecasting China’s producer price index for production materials via Gaussian process regression within a Bayesian inference framework 基于贝叶斯推理框架的高斯过程回归预测中国生产资料生产者价格指数
Pub Date : 2025-11-06 DOI: 10.1007/s43674-025-00084-y
Bingzi Jin, Xiaojie Xu

Projecting China’s producer price index (PPI) for production materials yields early signals of inflationary pressures and cost dynamics influencing both national economic stability and international supply networks. Reliable PPI forecasts equip policymakers, market participants, and firms with the information needed to refine monetary policy, pricing decisions, and resource allocation. This study proposes an innovative forecasting architecture based on Gaussian process regression (GPR), whose hyperparameters are estimated via a Bayesian inference procedure, enabling the model to adapt in real time to latent market fluctuations and previously unobserved structural shifts. By integrating these evolving characteristics, our approach more accurately captures changes in China’s PPI trajectory. The empirical analysis relies on a monthly dataset spanning October 1996 to February 2025, covering multiple waves of regulatory reform, industrial evolution, and macroeconomic transformation. Validation is performed over an out-of-sample period from June 2019 through February 2025, producing a relative root mean square error of 0.1120%, a root mean square error of 0.1131, a mean absolute error of 0.0832, and a correlation coefficient of 0.99984. To the best of our knowledge, this represents the first application of a Bayesian-inference-parameterized GPR model to forecast China’s PPI for production materials. Beyond advancing the theoretical discourse on machine-learning-based price prediction, the methodology provides a flexible analytical framework applicable to analogous macroeconomic time-series forecasting challenges.

预测中国生产材料的生产者价格指数(PPI)可以提供影响国家经济稳定和国际供应网络的通胀压力和成本动态的早期信号。可靠的PPI预测为政策制定者、市场参与者和企业提供了完善货币政策、定价决策和资源配置所需的信息。本研究提出了一种基于高斯过程回归(GPR)的创新预测架构,其超参数通过贝叶斯推理过程估计,使模型能够实时适应潜在的市场波动和先前未观察到的结构变化。通过整合这些不断变化的特征,我们的方法更准确地捕捉到了中国PPI轨迹的变化。实证分析依赖于1996年10月至2025年2月的月度数据集,涵盖了监管改革、产业演进和宏观经济转型的多波浪潮。验证在2019年6月至2025年2月的样本外期间进行,产生的相对均方根误差为0.1120%,均方根误差为0.1131,平均绝对误差为0.0832,相关系数为0.99984。据我们所知,这是首次应用贝叶斯推理参数化探地雷达模型来预测中国生产材料的PPI。除了推进基于机器学习的价格预测的理论论述之外,该方法还提供了一个灵活的分析框架,适用于类似的宏观经济时间序列预测挑战。
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引用次数: 0
Comparative performance analysis of a novel fusion-based algorithm for AGV navigation 一种基于融合的AGV导航新算法性能对比分析
Pub Date : 2025-10-29 DOI: 10.1007/s43674-025-00083-z
Ata Jahangir Moshayedi, Dangling Xu, Maryam Sharifdoust, Amir Sohail Khan, Zeashan Hameed Khan, Mehran Emadi Andani

Automated guided vehicles (AGVs) are intelligent robotic systems that play a crucial role in applications, such as transportation, food delivery, and medical emergencies. One of the primary challenges in AGV deployment is achieving precise navigation to ensure task reliability, safety, and efficient battery consumption along predetermined routes. Vision-based methods have gained significant attention for their high performance in robot navigation. However, selecting the most effective algorithm with minimal sensor use remains an active area of research. This study introduces a novel and efficient fusion-based navigation method, termed the Extended Fusion 1 Method (EFM1), which integrates data from camera and infrared (IR) sensors. The system leverages feature-based algorithms, such as SIFT, ORB, FAST, SURF, BRISK, and BRIEF, to improve path-tracking accuracy. The main objective of this fusion approach is to enhance navigational precision and identify the most suitable algorithm for robust AGV path-tracking. The EFM1 method is simulated and validated using the CoppeliaSim (V-REP) simulator, incorporating the real-world dimensions of the previously developed AGV model, Hongma, via Python API. The simulation evaluates six feature-based algorithms across five distinct path types: circular, elliptical, spiral, figure-eight, and custom path. Performance is assessed in terms of maximum achievable speed, minimal path-tracking error, body orientation accuracy, and simulation time. Statistical analysis, including inferential techniques and post hoc tests, is used to interpret the results. The experimental findings demonstrate that the proposed EFM1 algorithm outperforms traditional vision-only approaches in effectively tracking all five path types, confirming its potential for reliable and efficient AGV navigation. The proposed EFM1 algorithm integrates vision and IR sensors, enhancing AGV navigation accuracy by up to 84% while using minimal sensors. It outperforms previous methods by delivering up to 22.2% faster simulation times, significantly reduced error rates (for example, ORB error decreased by 93%), and increased speed across five test paths. The comparison between investigated methods shows that FAST excels on dynamic paths with notable speed improvements, while SURF performs better on complex trajectories as confirmed by statistical analysis. Although EFM1 improves most metrics, body orientation changes increased, indicating a trade-off between agility and movement stability.

自动导引车(agv)是智能机器人系统,在运输、食品配送和医疗紧急情况等应用中发挥着至关重要的作用。AGV部署的主要挑战之一是实现精确导航,以确保任务的可靠性、安全性和沿预定路线的高效电池消耗。基于视觉的机器人导航方法以其优异的性能得到了广泛的关注。然而,如何在最小的传感器使用量下选择最有效的算法仍然是一个活跃的研究领域。本研究介绍了一种新颖高效的基于融合的导航方法,称为扩展融合1方法(EFM1),该方法集成了来自相机和红外(IR)传感器的数据。该系统利用SIFT、ORB、FAST、SURF、BRISK和BRIEF等基于特征的算法来提高路径跟踪的准确性。该融合方法的主要目的是提高导航精度,识别出最适合AGV鲁棒路径跟踪的算法。EFM1方法使用CoppeliaSim (V-REP)模拟器进行模拟和验证,通过Python API结合先前开发的AGV模型Hongma的实际尺寸。仿真评估了五种不同路径类型的六种基于特征的算法:圆形、椭圆、螺旋、数字8和自定义路径。性能是根据最大可达到的速度、最小的路径跟踪误差、身体方向精度和模拟时间来评估的。统计分析,包括推论技术和事后检验,被用来解释结果。实验结果表明,所提出的EFM1算法在有效跟踪所有五种路径类型方面优于传统的纯视觉方法,证实了其可靠高效的AGV导航潜力。提出的EFM1算法集成了视觉和红外传感器,在使用最小传感器的情况下,将AGV导航精度提高了84%。它比以前的方法快了22.2%的模拟时间,显著降低了错误率(例如,ORB错误减少了93%),并提高了五个测试路径的速度。两种方法的对比表明,FAST在动态路径上表现优异,速度显著提高,而SURF在复杂路径上表现更好,统计分析证实了这一点。虽然EFM1改善了大多数指标,但身体方向的变化增加了,这表明了敏捷性和运动稳定性之间的权衡。
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引用次数: 0
An innovative approach to hesitant bipolar fuzzy soft sets in multi-criteria group decision-making 多准则群体决策中犹豫双极模糊软集的创新方法
Pub Date : 2025-06-24 DOI: 10.1007/s43674-025-00082-0
Ajoy Kanti Das, Suman Patra, Carlos Granados

This paper explores the integration of hesitant bipolar fuzzy soft sets (HBFSS) into multi-criteria group decision-making (MCGDM), aiming to enhance decision precision and resolve uncertainties in expert evaluations. We introduce a novel decision-making framework that combines the root mean square deviation (RMSD) method with a credibility score, capturing both the proximity to ideal solutions and the consistency of expert opinions. The process is applied to a sustainable energy project selection problem, showcasing its efficacy in ranking alternatives such as solar farm, wind park, and hydroelectric plant. A comparative analysis with the existing model highlights the limitations of traditional approaches, including the failure to differentiate alternatives with similar scores and neglecting expert consistency. Our results demonstrate that the proposed RMSD-Credibility approach offers a more nuanced, consistent, and precise ranking, improving decision quality in complex, uncertain environments. This paper contributes to advancing decision-making under fuzzy and uncertain conditions by providing an innovative aggregation mechanism tailored to the challenges of real-world multi-criteria problems.

探讨了将犹豫双极模糊软集(HBFSS)集成到多准则群体决策(MCGDM)中,以提高决策精度,解决专家评价中的不确定性。我们引入了一种新的决策框架,该框架将均方根偏差(RMSD)方法与可信度评分相结合,同时捕获了与理想解决方案的接近性和专家意见的一致性。该过程应用于可持续能源项目选择问题,展示了其对太阳能农场、风力公园和水力发电厂等替代方案进行排名的有效性。与现有模型的比较分析突出了传统方法的局限性,包括无法区分具有相似分数的备选方案和忽略专家一致性。我们的研究结果表明,提出的rmsd -可信度方法提供了更细致、一致和精确的排名,提高了复杂、不确定环境中的决策质量。本文通过提供一种针对现实世界多准则问题挑战的创新聚合机制,有助于推进模糊和不确定条件下的决策。
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引用次数: 0
A predictive contrivance for recognising traits in keystroke dynamics 一种识别击键动力学特征的预测装置
Pub Date : 2025-05-29 DOI: 10.1007/s43674-025-00081-1
Soumen Roy, Utpal Roy, Devadatta Sinha, Rajat Kumar Pal

Predicting personal traits, particularly age group, gender, handedness, and hand(s) used, in the form of digital identity for smartphone users by analysing keystroke dynamics (KD) attributes is a challenging area. However, it has a variety of applications in e-commerce, e-banking, e-teaching/learning, e-exams, forensics, and social networking. The main bottleneck of this problem is addressing the imbalanced nature of KD datasets using conventional machine learning (ML) approaches. By their inherent nature, KD datasets are often imbalanced from various perspectives due to the non-uniformity of diverse user traits and their varied usage patterns. This study proposes a predictive model for both fixed and free-text modes, considering the effect of attached smartphone sensors. We adopt a score-level fusion of eXtreme Gradient Boosting (XGBoost) models on several balanced bootstrapped training samples to address the limitations of conventional approaches. This ensemble approach utilizes multiple bootstrapped training sets, where the class distribution in each set is equally balanced for more accurate and robust performance. Furthermore, we observe the positive impact of incorporating these prediction scores and labels with primary biometric attributes in KD-based user authentication and identification, both in static/entry-point and continuous/active security designs—a previously unanswered challenges. The predictive mechanism and its adaptation in unique KD-based designs, based on datasets collected from a considerable number of volunteers with diverse age groups, genders, professions, and education levels through a smartphone in a web environment, demonstrate the novelty of our approach.

通过分析击键动力学(KD)属性,以智能手机用户数字身份的形式预测个人特征,特别是年龄组、性别、用手习惯和使用的手,是一个具有挑战性的领域。然而,它在电子商务、电子银行、电子教学/学习、电子考试、取证和社会网络中有各种各样的应用。该问题的主要瓶颈是使用传统的机器学习(ML)方法解决KD数据集的不平衡性。由于其固有的性质,由于不同用户特征的不均匀性及其不同的使用模式,KD数据集往往从不同的角度来看是不平衡的。本研究提出了一个固定和自由文本模式的预测模型,考虑了附加智能手机传感器的影响。我们在几个平衡的自举训练样本上采用极限梯度提升(XGBoost)模型的分数级融合来解决传统方法的局限性。这种集成方法利用多个自举训练集,其中每个集中的类分布均匀平衡,以获得更准确和鲁棒的性能。此外,我们观察到在基于kd的用户身份验证和识别中,将这些预测分数和标签与主要生物特征属性结合起来的积极影响,无论是在静态/入口点还是持续/主动安全设计中,这都是以前未解决的挑战。预测机制及其在独特的基于kd的设计中的适应性,基于通过网络环境中的智能手机从大量不同年龄、性别、职业和教育水平的志愿者中收集的数据集,展示了我们方法的新颖性。
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引用次数: 0
Design of a DNN-based operator on edge device for keyword spotting 一种基于dnn算子的关键字定位边缘设备设计
Pub Date : 2025-04-16 DOI: 10.1007/s43674-025-00080-2
Chan Kok Wei, Hermawan Nugroho

Keyword spotting (KWS) is a critical component of voice-driven smart-device applications, requiring high accuracy, sensitivity, and responsiveness to deliver optimal user experiences. Given the always-on nature of KWS systems, minimizing computational complexity and power consumption is essential, particularly for battery-powered edge devices with constrained resources. In this paper, we propose a compact and highly efficient convolutional neural network (CNN) for edge-based KWS tasks, using the Google Speech Commands (GSC) V2 dataset for training and evaluation. Our model employs modified MobileNetV2 architecture, optimized via knowledge distillation from an ensemble of high-performing CNN models. Experimental results demonstrate that the proposed model achieves 94.48% accuracy on clean test data and significantly outperforms existing state-of-the-art edge models on challenging noisy test sets, reaching 86.38% accuracy. The proposed CNN maintains this superior performance with only 73.8K parameters and 19.5M floating-point operations (FLOPs)—approximately three times fewer FLOPs and substantially fewer parameters than previously reported edge-focused KWS models. Moreover, when evaluated on a realistic and challenging external Kaggle test set, the proposed model shows excellent generalization with 88.38% accuracy, surpassing baseline depthwise separable CNN (DS-CNN) approaches. Upon practical deployment on a widely used embedded computing platform, our optimized model achieved fast inference times between 11 ms and 14 ms per sample, outperforming existing baseline methods and confirming its suitability for real-time applications. This study highlights the successful integration of model compression techniques, including ensemble learning and knowledge distillation, to achieve breakthrough performance improvements in accuracy, robustness to noise, computational efficiency, and inference speed, thereby advancing the practical deployment of high-performance KWS solutions on resource-constrained edge devices.

关键字识别(KWS)是语音驱动的智能设备应用程序的关键组成部分,需要高精度、灵敏度和响应能力来提供最佳的用户体验。考虑到KWS系统始终在线的特性,最小化计算复杂性和功耗至关重要,特别是对于资源有限的电池供电边缘设备。在本文中,我们提出了一种紧凑高效的卷积神经网络(CNN),用于基于边缘的KWS任务,使用谷歌Speech Commands (GSC) V2数据集进行训练和评估。我们的模型采用改进的MobileNetV2架构,通过从高性能CNN模型集合中提取知识进行优化。实验结果表明,该模型在干净测试数据上的准确率为94.48%,在具有挑战性的噪声测试集上的准确率为86.38%,显著优于现有的边缘模型。所提出的CNN仅以73.8K参数和19.5M浮点运算(FLOPs)保持了这种优越的性能-大约比先前报道的边缘聚焦KWS模型少三倍的FLOPs和更少的参数。此外,当在一个现实且具有挑战性的外部Kaggle测试集上进行评估时,所提出的模型具有良好的泛化效果,准确率为88.38%,超过了基线深度可分离CNN (DS-CNN)方法。经过在广泛使用的嵌入式计算平台上的实际部署,我们优化的模型实现了每个样本在11 ms到14 ms之间的快速推理时间,优于现有的基线方法,并确认了其适用于实时应用。本研究强调了模型压缩技术(包括集成学习和知识蒸馏)的成功集成,在准确性、抗噪声鲁棒性、计算效率和推理速度方面实现了突破性的性能提升,从而推进了高性能KWS解决方案在资源受限边缘设备上的实际部署。
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引用次数: 0
Do images really do the talking? 图像真的能说话吗?
Pub Date : 2025-03-01 DOI: 10.1007/s43674-025-00079-9
Siddhanth U. Hegde, Adeep Hande, Ruba Priyadharshini, Sajeetha Thavareesan, Ratnasingam Sakuntharaj, Sathiyaraj Thangasamy, B. Bharathi, Bharathi Raja Chakravarthi

A meme is a part of media created to share an opinion or emotion across the internet. Due to their popularity, memes have become the new form of communication on social media. However, they are used in harmful ways such as trolling and cyberbullying progressively due to their nature. Various data modelling methods create different possibilities in feature extraction and turn them into beneficial information. The variety of modalities included in data plays a significant part in predicting the results. We try to explore the significance of visual features of images in classifying memes. Memes are a blend of both image and text, where the text is embedded into the picture. We consider a meme to be trolling if the meme in any way tries to troll a particular individual, group, or organisation. We try to incorporate the memes as a troll and non-trolling memes based on their images and text. We evaluate if there is any major significance of the visual features for identifying whether a meme is trolling or not. Our work illustrates different textual analysis methods and contrasting multimodal approaches ranging from simple merging to cross attention to utilising both worlds’—visual and textual features. The fine-tuned cross-lingual language model, XLM, performed the best in textual analysis, and the multimodal transformer performs the best in multimodal analysis.

模因是媒体的一部分,用来在互联网上分享观点或情感。由于其受欢迎程度,表情包已经成为社交媒体上新的交流形式。然而,由于它们的性质,它们被越来越多地用于有害的方式,如拖钓和网络欺凌。不同的数据建模方法为特征提取创造了不同的可能性,并将其转化为有益的信息。数据中包含的各种模式在预测结果方面起着重要作用。我们试图探讨图像的视觉特征在模因分类中的意义。模因是图像和文本的混合体,文本嵌入到图片中。如果一个模因试图以任何方式“喷子”某个特定的个人、团体或组织,我们就认为这个模因是“喷子”。我们试着根据图片和文字将这些表情包分为喷子表情包和非喷子表情包。我们评估是否有任何重大意义的视觉特征,以确定是否恶搞或不。我们的工作展示了不同的文本分析方法和对比的多模态方法,从简单的合并到交叉注意,再到利用两个世界的视觉和文本特征。经过微调的跨语言模型XLM在文本分析中表现最好,而多模态转换器在多模态分析中表现最好。
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引用次数: 0
Non-linear machine learning with sample perturbation augments leukemia relapse prognostics from single-cell proteomics measurements 带有样本扰动的非线性机器学习从单细胞蛋白质组学测量中增强了白血病复发预后能力
Pub Date : 2024-09-28 DOI: 10.1007/s43674-024-00078-2
Yu-Chen Lo

Developing accurate and robust prognostic prediction for classifying the risks of acute lymphoblastic leukemia (ALL) relapse is critical for patient treatment management and survival. However, the lack of clinical samples and linearity assumption remains a significant clinical challenge for achieving high accuracy for single-cell prognostics. Here, we explore the use of non-linear machine learning models with ex vivo sample perturbation as a data augmentation strategy to improve ALL relapse prediction. We hypothesize that treating each sample with ex vivo perturbation can be viewed as independent measurements, thus increasing the number of available observations for machine learning. We show that ex vivo sample stimulation combined with non-linear machine learning significantly improves the performance of ALL risk stratification from limited single-cell proteomic data.

为急性淋巴细胞白血病(ALL)复发风险分类开发准确、稳健的预后预测对患者的治疗管理和生存至关重要。然而,缺乏临床样本和线性假设仍然是实现单细胞高精度预后的重大临床挑战。在此,我们探索使用非线性机器学习模型和体内外样本扰动作为数据增强策略,以改善 ALL 复发预测。我们假设,用体内外扰动处理每个样本可被视为独立的测量,从而增加机器学习的可用观测数据。我们的研究表明,体内外样本刺激与非线性机器学习相结合,能显著提高从有限的单细胞蛋白质组数据中进行 ALL 风险分层的性能。
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引用次数: 0
ARBP: antibiotic-resistant bacteria propagation bio-inspired algorithm and its performance on benchmark functions ARBP:抗生素细菌传播生物启发算法及其在基准函数上的表现
Pub Date : 2024-09-06 DOI: 10.1007/s43674-024-00077-3
Kirti Aggarwal, Anuja Arora

Optimization algorithms are continuously evolving and considered as an active multidiscipline research area to design scalable solutions for complex optimization problems. Literature witnesses the constant effort by researchers to improve existing optimization algorithms or to develop a new algorithm to deal with single and multiple objective problems. This research paper presents a novel population-based, metaheuristic bio-inspired optimization algorithm. The algorithm contrived the propagation concept of antibiotic-resistant bacteria named as antibiotic-resistant bacteria propagation (ARBP) algorithm where properties of bacteria to acquire antibiotic resistance over time are used as a base concept. The optimization algorithm imitates the two prime mechanisms of horizontal gene transfer—Conjugation Gene Transfer Mechanism (CGTM) and Transformation Gene Transfer Mechanism (TGTM) to propagate antibiotic-resistant bacteria. CGTM and TGTM are used to explore the search space to handle single and multiple objective optimization problems. Conjugation mechanism is used for exploration of search space and exploitation concept is driven by transformation mechanism. The efficiency and importance of the ARBP algorithm are validated on varying classical and complex benchmark functions. An extensive comparative study is performed to detail the effectiveness of ARBP over other well-known swarm and evolutionary algorithms. This comparative analysis clearly depicts that the performance of ARBP is superior in terms of finding a better solution with high convergence as compared to other considered algorithms.

优化算法在不断发展,并被视为一个活跃的多学科研究领域,可为复杂的优化问题设计可扩展的解决方案。文献见证了研究人员为改进现有优化算法或开发新算法以处理单目标和多目标问题所做的不懈努力。本研究论文提出了一种新颖的基于种群的元启发式生物优化算法。该算法将抗生素耐药细菌的传播概念设计为抗生素耐药细菌传播(ARBP)算法,将细菌随时间获得抗生素耐药性的特性作为基本概念。该优化算法模仿水平基因转移的两种主要机制--共轭基因转移机制(CGTM)和转化基因转移机制(TGTM)来繁殖抗生素细菌。CGTM 和 TGTM 用于探索搜索空间,以处理单目标和多目标优化问题。共轭机制用于探索搜索空间,而利用概念则由转化机制驱动。ARBP 算法的效率和重要性在不同的经典和复杂基准函数上得到了验证。通过广泛的比较研究,详细说明了 ARBP 与其他著名的蜂群算法和进化算法相比的有效性。对比分析清楚地表明,与其他算法相比,ARBP 在找到更好的解决方案和高收敛性方面表现出色。
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Advances in computational intelligence
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