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Non-linear machine learning with sample perturbation augments leukemia relapse prognostics from single-cell proteomics measurements 带有样本扰动的非线性机器学习从单细胞蛋白质组学测量中增强了白血病复发预后能力
Pub Date : 2024-09-28 DOI: 10.1007/s43674-024-00078-2
Yu-Chen Lo

Developing accurate and robust prognostic prediction for classifying the risks of acute lymphoblastic leukemia (ALL) relapse is critical for patient treatment management and survival. However, the lack of clinical samples and linearity assumption remains a significant clinical challenge for achieving high accuracy for single-cell prognostics. Here, we explore the use of non-linear machine learning models with ex vivo sample perturbation as a data augmentation strategy to improve ALL relapse prediction. We hypothesize that treating each sample with ex vivo perturbation can be viewed as independent measurements, thus increasing the number of available observations for machine learning. We show that ex vivo sample stimulation combined with non-linear machine learning significantly improves the performance of ALL risk stratification from limited single-cell proteomic data.

为急性淋巴细胞白血病(ALL)复发风险分类开发准确、稳健的预后预测对患者的治疗管理和生存至关重要。然而,缺乏临床样本和线性假设仍然是实现单细胞高精度预后的重大临床挑战。在此,我们探索使用非线性机器学习模型和体内外样本扰动作为数据增强策略,以改善 ALL 复发预测。我们假设,用体内外扰动处理每个样本可被视为独立的测量,从而增加机器学习的可用观测数据。我们的研究表明,体内外样本刺激与非线性机器学习相结合,能显著提高从有限的单细胞蛋白质组数据中进行 ALL 风险分层的性能。
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引用次数: 0
ARBP: antibiotic-resistant bacteria propagation bio-inspired algorithm and its performance on benchmark functions ARBP:抗生素细菌传播生物启发算法及其在基准函数上的表现
Pub Date : 2024-09-06 DOI: 10.1007/s43674-024-00077-3
Kirti Aggarwal, Anuja Arora

Optimization algorithms are continuously evolving and considered as an active multidiscipline research area to design scalable solutions for complex optimization problems. Literature witnesses the constant effort by researchers to improve existing optimization algorithms or to develop a new algorithm to deal with single and multiple objective problems. This research paper presents a novel population-based, metaheuristic bio-inspired optimization algorithm. The algorithm contrived the propagation concept of antibiotic-resistant bacteria named as antibiotic-resistant bacteria propagation (ARBP) algorithm where properties of bacteria to acquire antibiotic resistance over time are used as a base concept. The optimization algorithm imitates the two prime mechanisms of horizontal gene transfer—Conjugation Gene Transfer Mechanism (CGTM) and Transformation Gene Transfer Mechanism (TGTM) to propagate antibiotic-resistant bacteria. CGTM and TGTM are used to explore the search space to handle single and multiple objective optimization problems. Conjugation mechanism is used for exploration of search space and exploitation concept is driven by transformation mechanism. The efficiency and importance of the ARBP algorithm are validated on varying classical and complex benchmark functions. An extensive comparative study is performed to detail the effectiveness of ARBP over other well-known swarm and evolutionary algorithms. This comparative analysis clearly depicts that the performance of ARBP is superior in terms of finding a better solution with high convergence as compared to other considered algorithms.

优化算法在不断发展,并被视为一个活跃的多学科研究领域,可为复杂的优化问题设计可扩展的解决方案。文献见证了研究人员为改进现有优化算法或开发新算法以处理单目标和多目标问题所做的不懈努力。本研究论文提出了一种新颖的基于种群的元启发式生物优化算法。该算法将抗生素耐药细菌的传播概念设计为抗生素耐药细菌传播(ARBP)算法,将细菌随时间获得抗生素耐药性的特性作为基本概念。该优化算法模仿水平基因转移的两种主要机制--共轭基因转移机制(CGTM)和转化基因转移机制(TGTM)来繁殖抗生素细菌。CGTM 和 TGTM 用于探索搜索空间,以处理单目标和多目标优化问题。共轭机制用于探索搜索空间,而利用概念则由转化机制驱动。ARBP 算法的效率和重要性在不同的经典和复杂基准函数上得到了验证。通过广泛的比较研究,详细说明了 ARBP 与其他著名的蜂群算法和进化算法相比的有效性。对比分析清楚地表明,与其他算法相比,ARBP 在找到更好的解决方案和高收敛性方面表现出色。
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引用次数: 0
Detection and classification of diabetic retinopathy based on ensemble learning 基于集合学习的糖尿病视网膜病变检测与分类
Pub Date : 2024-07-27 DOI: 10.1007/s43674-024-00076-4
Ankur Biswas, Rita Banik

Fundus images are a powerful tool for detecting a variety of retinal disorders. Regular screening of the retina can lead to early detection of conditions like diabetic retinopathy, allowing for timely intervention and treatment. This study is focussed on developing an automated diagnostic system that can accurately detect different stages of diabetic retinopathy. Our approach involves leveraging pre-trained deep learning system to extract important features from fundus images. These features are then employed in a classification system that categorises the images into five stages of retinopathy based on ensemble algorithms. We employ ensemble algorithms like Random forest and XGBoost for classification to improve the accuracy and predictability of the forecast. This drives our focus on enhancing the interpretability and explainability of the model. We trained the model using publicly available fundus images of diabetic individuals for grading and compared the classification results obtained from ensemble techniques with those from deep learning models that used pre-trained weights and biases. The best performing ensemble showed an accuracy range of 0.63 to 0.79. Moreover, the accuracy of 0.96 in detecting the presence of retinopathy provides strong evidence of the approach’s effectiveness, contributing to its reliability, and potential for early diagnosis.

眼底图像是检测各种视网膜疾病的有力工具。定期检查视网膜可以及早发现糖尿病视网膜病变等疾病,以便及时干预和治疗。这项研究的重点是开发一种能准确检测糖尿病视网膜病变不同阶段的自动诊断系统。我们的方法包括利用预先训练好的深度学习系统从眼底图像中提取重要特征。然后将这些特征用于分类系统,该系统根据集合算法将图像分为视网膜病变的五个阶段。我们采用随机森林和 XGBoost 等集合算法进行分类,以提高预测的准确性和可预测性。这促使我们将重点放在提高模型的可解释性和可说明性上。我们使用公开的糖尿病患者眼底图像对模型进行了分级训练,并将集合技术获得的分类结果与使用预先训练的权重和偏差的深度学习模型的分类结果进行了比较。表现最好的集合的准确率范围为 0.63 至 0.79。此外,检测视网膜病变的准确率为 0.96,这有力地证明了该方法的有效性、可靠性和早期诊断的潜力。
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引用次数: 0
Office real estate price index forecasts through Gaussian process regressions for ten major Chinese cities 通过高斯过程回归预测中国十个主要城市的办公楼房地产价格指数
Pub Date : 2024-07-22 DOI: 10.1007/s43674-024-00075-5
Bingzi Jin, Xiaojie Xu

During the last decade, the Chinese housing market has seen fast expansion, and the importance of housing price forecasts has surely increased, becoming an essential problem for policymakers and investors. In this article, we explore Gaussian process regressions across different kernels and basis functions for monthly office real estate price index forecasts for ten major Chinese cities from July 2005 to April 2021 using cross-validation and Bayesian optimizations that could endow the forecast models with higher adaptability and better generalization performance. The models constructed offer precise out-of-sample forecasts from May 2019 to April 2021 with relative root mean square errors ranging from 0.0205 to 0.5300% across the ten price indices. Benchmark analysis against the autoregressive model, autoregressive-generalized autoregressive conditional heteroskedasticity model, nonlinear autoregressive neural network model, support vector regression model, and regression tree model suggests that the Gaussian process regression model leads to statistically significant higher accuracy. Our findings might be utilized independently or in conjunction with other projections to create views on office real estate price index movements and undertake further policy research.

近十年来,中国房地产市场快速发展,房价预测的重要性也随之增加,成为政策制定者和投资者必须解决的问题。在本文中,我们利用交叉验证和贝叶斯优化方法,探索了不同核和基函数的高斯过程回归,用于预测 2005 年 7 月至 2021 年 4 月中国十个主要城市的月度办公楼房地产价格指数,从而使预测模型具有更高的适应性和更好的泛化性能。所构建的模型可提供 2019 年 5 月至 2021 年 4 月的精确样本外预测,十个价格指数的相对均方根误差在 0.0205% 至 0.5300% 之间。与自回归模型、自回归-广义自回归条件异方差模型、非线性自回归神经网络模型、支持向量回归模型和回归树模型进行的基准分析表明,高斯过程回归模型在统计意义上具有更高的准确性。我们的研究结果可以单独使用,也可以与其他预测结果结合使用,以形成对办公房地产价格指数走势的看法,并开展进一步的政策研究。
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引用次数: 0
Systematic micro-breaks affect concentration during cognitive comparison tasks: quantitative and qualitative measurements 系统性微小间歇影响认知比较任务中的注意力:定量和定性测量
Pub Date : 2024-06-18 DOI: 10.1007/s43674-024-00074-6
Orchida Dianita, Kakeru Kitayama, Kimi Ueda, Hirotake Ishii, Hiroshi Shimoda, Fumiaki Obayashi

An approach to improve workers’ productivity performance without neglecting their well-being should be investigated. To elucidate the effects of systematic micro-break on intellectual concentration performance, a controlled laboratory experiment generated 31 participants’ data when each participant was performing cognitive comparison tasks. Systematic micro-break was given for 20 s after 7.5 min of cognitive work, for a total of 25 min of work tasks. Each participant performed the task under both conditions with and without micro-break intervention in a counterbalanced design. Two quantitative evaluations were made: the answering time and concentration time ratio. A subjective symptom questionnaire and the NASA task load index were applied for analytical consideration. The average answering time indicates that the performance under the influence of micro-break tends to be more stable over time and that it mitigates performance degradation compared to the performance in a condition without micro-break. For concentration time ratio scores, no significant difference was found between conditions with micro-break and without micro-break. However, a tendency was apparent by which the concentration time ratio score was higher in a condition with micro-break, which suggests higher cognitive performance. The subjective symptoms questionnaire indicated no significant difference between conditions with and without micro-break. Weighted NASA task load index questionnaire results indicated significant difference between both conditions with lower workload scores in conditions with micro-break. Results obtained from this study suggest that the implementation of systematic micro-break can support workers’ performance stability over time. Therefore, systematic micro-break can be promoted as a promising strategy for work recovery.

应该研究一种既能提高工人的工作效率,又不忽视其身心健康的方法。为了阐明系统性微休息对智力集中表现的影响,一项受控实验室实验得出了 31 名参与者在执行认知比较任务时的数据。在进行了 7.5 分钟的认知工作后,系统性微休息时间为 20 秒,总共 25 分钟的工作任务。每位受试者在有微休息干预和无微休息干预的两种条件下完成任务,采用平衡设计。进行了两项定量评估:回答时间和集中注意力时间比。主观症状问卷和 NASA 任务负荷指数被用于分析考量。平均答题时间表明,在微断时间的影响下,学习成绩随着时间的推移趋于稳定,与没有微断时间的情况相比,它能减轻学习成绩的下降。在集中时间比率得分方面,有微断和无微断条件下没有发现明显差异。但有一个明显的趋势,即在有微休息的情况下,注意力集中时间比率得分更高,这表明认知能力更强。主观症状问卷显示,在有微休息和没有微休息的情况下没有明显差异。加权纳斯卡任务负荷指数问卷调查结果表明,有微小休息时间的情况下工作负荷得分较低,而无微小休息时间的情况下工作负荷得分较高。本研究的结果表明,实施系统性微间歇可以帮助工人在一段时间内保持稳定的工作表现。因此,系统性微休息可以作为一种有前途的工作恢复策略加以推广。
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引用次数: 0
Recognising small colour changes with unsupervised learning, comparison of methods 通过无监督学习识别微小的颜色变化,方法比较
Pub Date : 2024-04-16 DOI: 10.1007/s43674-024-00073-7
Jari Isohanni

Colour differentiation is crucial in machine learning and computer vision. It is often used when identifying items and objects based on distinct colours. While common colours like blue, red, green, and yellow are easily distinguishable, some applications require recognising subtle colour variations. Such demands arise in sectors like agriculture, printing, healthcare, and packaging. This research employs prevalent unsupervised learning techniques to detect printed colours on paper, focusing on CMYK ink (saturation) levels necessary for recognition against a white background. The aim is to assess whether unsupervised clustering can identify colours within QR-Codes. One use-case for this research is usage of functional inks, ones that change colour based on environmental factors. Within QR-Codes they serve as low-cost IoT sensors. Results of this research indicate that K-means, C-means, Gaussian Mixture Model (GMM), Hierarchical clustering, and Spectral clustering perform well in recognising colour differences when CMYK saturation is 20% or higher in at least one channel. K-means stands out when saturation drops below 10%, although its accuracy diminishes significantly, especially for yellow or magenta channels. A saturation of at least 10% in one CMYK channel is needed for reliable colour detection using unsupervised learning. To handle ink densities below 5%, further research or alternative unsupervised methods may be necessary.

颜色区分在机器学习和计算机视觉中至关重要。它通常用于根据不同的颜色识别物品和物体。虽然蓝、红、绿、黄等常见颜色很容易区分,但有些应用需要识别细微的颜色变化。这类需求出现在农业、印刷、医疗保健和包装等领域。这项研究采用了流行的无监督学习技术来检测纸张上的印刷色彩,重点是在白色背景下识别所需的 CMYK 油墨(饱和度)级别。目的是评估无监督聚类能否识别 QR 码中的颜色。这项研究的一个用例是使用功能性油墨,即根据环境因素改变颜色的油墨。在 QR-Codes 中,它们可用作低成本的物联网传感器。研究结果表明,当至少一个通道的 CMYK 饱和度达到或超过 20% 时,K-means、C-means、高斯混合模型 (GMM)、层次聚类和光谱聚类在识别颜色差异方面表现良好。当饱和度低于 10%时,K-means 的准确性会明显下降,尤其是黄色或洋红色通道。使用无监督学习技术进行可靠的颜色检测,一个 CMYK 通道的饱和度至少要达到 10%。要处理低于 5% 的油墨密度,可能需要进一步研究或采用其他无监督方法。
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引用次数: 0
Personal color analysis using color space algorithm 利用色彩空间算法进行个人色彩分析
Pub Date : 2024-04-10 DOI: 10.1007/s43674-024-00071-9
Tanakorn Withurat, Wannapa Sripen, Juntanee Pattanasukkul, Witsarut Wongsim, Suchawalee Jeeratanyasakul, Thitirat Siriborvornratanakul

This study builds upon the research conducted on the personal color decision system. It employs color space logic and reduces limitations associated with capturing photos, aiming to enhance the existing personal color decision method. The objective is to obtain more reliable and objective results for personal color analysis. Our proposed approach focuses on developing a comprehensive color selection framework by leveraging personal color databases and employing decision tree methods. The findings of this research suggest that utilizing personal color analysis in image creation can assist individuals in cultivating a positive and confident image, which holds significance in interpersonal relationships and social interactions.

本研究以个人色彩决策系统的研究为基础。它采用色彩空间逻辑,减少了与拍摄照片相关的限制,旨在改进现有的个人色彩决策方法。目的是为个人色彩分析获得更可靠、更客观的结果。我们提出的方法主要是利用个人色彩数据库和决策树方法,开发一个全面的色彩选择框架。研究结果表明,在图像创作中利用个人色彩分析可以帮助个人培养积极自信的形象,这在人际关系和社会交往中具有重要意义。
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引用次数: 0
Application of artificial intelligence models to predict the compressive strength of concrete 应用人工智能模型预测混凝土抗压强度
Pub Date : 2024-04-06 DOI: 10.1007/s43674-024-00072-8
Lucas Elias de Andrade Cruvinel, Wanderlei Malaquias Pereira Jr., Amanda Isabela de Campos, Rogério Pinto Espíndola, Antover Panazzolo Sarmento, Daniel de Lima Araújo, Gustavo de Assis Costa, Roberto Viegas Dutra

The concrete mixture design and mix proportioning procedure, along with its influence on the compressive strength of concrete, is a well-known problem in civil engineering that requires the execution of numerous tests. With the emergence of modern machine learning techniques, the possibility of automating this process has become a reality. However, a significant volume of data is necessary to take advantage of existing models and algorithms. Recent literature presents different datasets, each with its own unique details, for training their models. In this paper, we integrated some of these existing datasets to improve training and, consequently, the models' results. Therefore, using this new dataset, we tested various models for the prediction task. The resulting dataset comprises 2358 records with seven input variables related to the mixture design, while the output represents the compressive strength of concrete. The dataset was subjected to several pre-processing techniques, and afterward, machine learning models, such as regressions, trees, and ensembles, were used to estimate the compressive strength. Some of these methods proved satisfactory for the prediction problem, with the best models achieving a coefficient of determination (R2) above 80%. Furthermore, a website with the trained model was created, allowing professionals in the field to utilize the AI technique in their everyday problem-solving.

混凝土混合物设计和混合配比程序及其对混凝土抗压强度的影响是土木工程中一个众所周知的问题,需要进行大量试验。随着现代机器学习技术的出现,这一过程的自动化已成为现实。然而,要利用现有的模型和算法,需要大量的数据。最近的文献介绍了不同的数据集,每个数据集都有其独特的细节,用于训练模型。在本文中,我们整合了其中一些现有的数据集,以改进训练,从而改善模型的结果。因此,我们使用这个新数据集测试了各种预测任务模型。由此产生的数据集包含 2358 条记录,其中有七个与混合物设计相关的输入变量,而输出则代表混凝土的抗压强度。数据集采用了多种预处理技术,然后使用回归、树和集合等机器学习模型来估算抗压强度。其中一些方法被证明对预测问题令人满意,最佳模型的判定系数 (R2) 超过了 80%。此外,还创建了一个包含训练模型的网站,使该领域的专业人员能够在日常解决问题时利用人工智能技术。
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引用次数: 0
Real-time weight training counting and correction using MediaPipe 使用 MediaPipe 进行实时重量训练计数和校正
Pub Date : 2024-03-18 DOI: 10.1007/s43674-024-00070-w
Thananan Luangaphirom, Sirirat Lueprasert, Phopthorn Kaewvichit, Siraphong Boonphotsiri, Tanakorn Burapasikarin, Thitirat Siriborvornratanakul

This study introduces a web application designed to address the challenge of ensuring correct posture and performance in weightlifting exercises, with a particular focus on fundamental bodyweight movements targeting various body parts. The problem at hand primarily concerns beginners who require guidance for accurate exercise execution. To tackle this issue, the tool leverages a live camera in conjunction with the MediaPipe and OpenCV frameworks to extract key points from the user's body. It concentrates on seven core exercise postures, using these key points to calculate numerical values and angles. Users are required to adjust their view angles to activate the tool's pose estimation functions. An algorithm, based on predefined rules that determine posture thresholds and angles between three key points, is employed to detect incorrect postures, provide real-time feedback, and track repetition counts. The completion of all required stages is necessary to count a repetition as correct. Additionally, in this study, we have expanded the algorithm to include three new exercise postures: Bent over Dumbbell Row, Seated Triceps Press, and Dumbbell Fly. We have also adapted the system to detect the lying down view, which is essential for the Dumbbell Fly posture. The results of testing this application demonstrate further development potential, particularly in enhancing the model’s framework to accommodate challenges such as high light intensity, pale skin tones, and instances when a body part is obscured by an object.

本研究介绍了一款网络应用程序,旨在解决在举重练习中确保正确姿势和表现的难题,尤其侧重于针对身体各部位的基本举重动作。当前的问题主要涉及初学者,他们需要指导才能准确地进行练习。为了解决这个问题,该工具利用实时摄像头,结合 MediaPipe 和 OpenCV 框架,提取用户身体的关键点。它专注于七个核心运动姿势,利用这些关键点来计算数值和角度。用户需要调整视角来激活工具的姿势估计功能。算法基于预定义规则,确定姿势阈值和三个关键点之间的角度,用于检测错误姿势、提供实时反馈和跟踪重复次数。只有完成了所有必要的阶段,重复才算正确。此外,在本研究中,我们还扩展了算法,增加了三种新的练习姿势:弯举哑铃、坐姿肱三头肌推举和哑铃飞举。我们还对该系统进行了调整,以检测对哑铃飞鸟姿势至关重要的俯卧视图。该应用的测试结果显示了进一步开发的潜力,尤其是在增强模型框架以应对高光照强度、苍白肤色以及身体部位被物体遮挡等挑战方面。
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引用次数: 0
StyleGAN2-ADA and Real-ESRGAN: Thai font generation with generative adversarial networks StyleGAN2-ADA 和 Real-ESRGAN:利用生成式对抗网络生成泰文字体
Pub Date : 2024-02-22 DOI: 10.1007/s43674-024-00069-3
Nidchapan Nitisukanan, Chotika Boonthaweechok, Prapatsorn Tiawpanichkij, Juthamas Pissakul, Naliya Maneesawangwong, Thitirat Siriborvornratanakul

Contemporary font design is a labor-intensive process. To address this, we utilize deep learning, specifically StyleGAN2-ADA and Real-ESRGAN, for automated Thai font generation. StyleGAN2-ADA incorporates adaptive discriminator augmentation (ADA) for image synthesis. By integrating Real-ESRGAN, font quality is enhanced. Our approach produces diverse, high-resolution fonts, as demonstrated in comparative experiments. In a survey with 50 participants, StyleGAN2-ADA without augmentation proves superior in legibility and visual appeal, while StyleGAN2-ADA with augmentation excels in diversity. This research highlights the efficiency of deep learning in creating high-quality Thai fonts and has implications for automated font design advancement.

现代字体设计是一个劳动密集型过程。为了解决这个问题,我们利用深度学习,特别是 StyleGAN2-ADA 和 Real-ESRGAN,来自动生成泰文字体。StyleGAN2-ADA 将自适应判别器增强(ADA)用于图像合成。通过集成 Real-ESRGAN,字体质量得到了提升。对比实验证明,我们的方法可以生成多样化、高分辨率的字体。在一项有 50 名参与者参与的调查中,没有增强功能的 StyleGAN2-ADA 在可读性和视觉吸引力方面更胜一筹,而有增强功能的 StyleGAN2-ADA 则在多样性方面表现出色。这项研究凸显了深度学习在创建高质量泰文字体方面的效率,并对自动字体设计的发展具有重要意义。
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引用次数: 0
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Advances in computational intelligence
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