Sara Rizwan Uppal, R. Uppal, Aftab Ahmad Khan, U. Saeed, Zahra Zahid Piracha, Zuhaib Ali
{"title":"Estimating the Prevalence of Fungal Nail Infections and Potential Concerns for Central Disease Surveillance Hub in Pakistan","authors":"Sara Rizwan Uppal, R. Uppal, Aftab Ahmad Khan, U. Saeed, Zahra Zahid Piracha, Zuhaib Ali","doi":"10.26502/acbr.50170260","DOIUrl":"https://doi.org/10.26502/acbr.50170260","url":null,"abstract":"","PeriodicalId":72279,"journal":{"name":"Archives of clinical and biomedical research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69340579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Impact of Public Health Interventions on the Covid-19 Epidemic: A Stochastic Model Based on Data from an African Island","authors":"Nuckchady Dc","doi":"10.26502/acbr.50170265","DOIUrl":"https://doi.org/10.26502/acbr.50170265","url":null,"abstract":"","PeriodicalId":72279,"journal":{"name":"Archives of clinical and biomedical research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69340668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Manami Tanaka, Tomoo Tanaka, Xiaolong Zhu, Fei Teng, Hong Lin, Zhu-Quan Luo, Ying Pan, S. Sadahiro, Toshiyuki Suzuki, Y. Maeda, Ding Wei, Zheng Lu
Although striking effects of vaccination strategy against COVID-19 world-wide, a long-term influence by sequential viral mRNA injections are unknown. We analysed biological alterations by total RNA sequencing in Pfizer-BioNTech vaccinated normal healthy volunteers and cancer patients, with or without adjuvant Huaier therapy. A significant destruction in ribosomal RNA structures was identified, enhanced by serial shots. Unlike the destruction caused by chemotherapy with platinum (II) complex, progressive destruction in 18S ribosome was identified even at 6 months after vaccination. The influence resulted in massive inhibition of translation and transcription, significantly in intra/inter neural signaling transfer and in lipid metabolism, related to ageing process. Huaier compensated these dysfunctions by miRNA-mediated transcriptional control, by typical activation in PI3K/AKT signaling pathway. Gene Ontology analysis revealed spontaneous virion production in number even after 3 months of the first vaccination. Present study indicated that the adjuvant therapy like Huaier compensates accelerated ageing process by mRNA vaccination.
{"title":"Huaier Effects on Functional Compensation with Destructive Ribosomal RNA Structure after Anti-SARS-CoV-2 mRNA Vaccination","authors":"Manami Tanaka, Tomoo Tanaka, Xiaolong Zhu, Fei Teng, Hong Lin, Zhu-Quan Luo, Ying Pan, S. Sadahiro, Toshiyuki Suzuki, Y. Maeda, Ding Wei, Zheng Lu","doi":"10.26502/acbr.50170267","DOIUrl":"https://doi.org/10.26502/acbr.50170267","url":null,"abstract":"Although striking effects of vaccination strategy against COVID-19 world-wide, a long-term influence by sequential viral mRNA injections are unknown. We analysed biological alterations by total RNA sequencing in Pfizer-BioNTech vaccinated normal healthy volunteers and cancer patients, with or without adjuvant Huaier therapy. A significant destruction in ribosomal RNA structures was identified, enhanced by serial shots. Unlike the destruction caused by chemotherapy with platinum (II) complex, progressive destruction in 18S ribosome was identified even at 6 months after vaccination. The influence resulted in massive inhibition of translation and transcription, significantly in intra/inter neural signaling transfer and in lipid metabolism, related to ageing process. Huaier compensated these dysfunctions by miRNA-mediated transcriptional control, by typical activation in PI3K/AKT signaling pathway. Gene Ontology analysis revealed spontaneous virion production in number even after 3 months of the first vaccination. Present study indicated that the adjuvant therapy like Huaier compensates accelerated ageing process by mRNA vaccination.","PeriodicalId":72279,"journal":{"name":"Archives of clinical and biomedical research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69340694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comparative Effectiveness of and Maternal Acceptability with Cervical Ripening using Cervical Massage Versus Membrane Sweep (CEASELESS): A Randomized Controlled Trial","authors":"Madugalle Tmssb, Jayasundara Dmcs","doi":"10.26502/acbr.50170269","DOIUrl":"https://doi.org/10.26502/acbr.50170269","url":null,"abstract":"","PeriodicalId":72279,"journal":{"name":"Archives of clinical and biomedical research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69340795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vincent Dossou Sodjinou, M. Keita, D. Chamla, J. Kimenyi, F. Braka, A. Talisuna, Harsh Lata, G. Mbayo, Fred Kapaya, Tamayi Mlanda, Nannie Ishata Conteh, Abdou Salam Gueye.
Introduction: Cholera remains one of the major threats to the global health security the World Health African at least ten affected yearly. Objective: This study assessed the countries’ readiness to prevent, detect, respond and recover from cholera outbreaks. Methods: This descriptive and cross-sectional study targeted 28 countries at risk of cholera. A readiness tool, covering all pillars required by the global health security was developed. Criteria, fit-tested with the regional framework for cholera elimination by 2030, were defined for each pillar. Based on experts’ opinion, each pillar and corresponding criteria were weighted. Data was collected in each country through group discussion of multi-sectoral cholera teams. The data collected were analyzed and visualized through an online Power BI tool. The readiness for each pillar was rated good if the pillar assessment result reached at least 80 % of expected points. The readiness was moderate if ranging between 50 % and 80 %. The readiness was limited if the rating was below 50%. The readiness status of each country was based on the same criteria. Results: The overall countries’ readiness level to detect and respond to cholera was insufficient. Of the 23 responding countries, there was no country with good readiness. Seven countries had moderate readiness while sixteen had limited readiness level. Laboratory was the best performing pillar with good readiness reported in eight countries. Only three countries had good readiness level for surveillance, two countries for infection prevention and control, and one country respectively for coordination and, water sanitation and hygiene. Conclusion: Countries in the WHO African Region were not adequately prepared to prevent or control cholera outbreak. Such readiness assessment provided critical information about areas of improvement across the 11 pillars and should be regularly undertaken to monitor progress in readiness capacity in the Region.
{"title":"Assessment of the Countries’ Readiness to Detect and Control Cholera Outbreaks in the WHO African Region","authors":"Vincent Dossou Sodjinou, M. Keita, D. Chamla, J. Kimenyi, F. Braka, A. Talisuna, Harsh Lata, G. Mbayo, Fred Kapaya, Tamayi Mlanda, Nannie Ishata Conteh, Abdou Salam Gueye.","doi":"10.26502/acbr.50170277","DOIUrl":"https://doi.org/10.26502/acbr.50170277","url":null,"abstract":"Introduction: Cholera remains one of the major threats to the global health security the World Health African at least ten affected yearly. Objective: This study assessed the countries’ readiness to prevent, detect, respond and recover from cholera outbreaks. Methods: This descriptive and cross-sectional study targeted 28 countries at risk of cholera. A readiness tool, covering all pillars required by the global health security was developed. Criteria, fit-tested with the regional framework for cholera elimination by 2030, were defined for each pillar. Based on experts’ opinion, each pillar and corresponding criteria were weighted. Data was collected in each country through group discussion of multi-sectoral cholera teams. The data collected were analyzed and visualized through an online Power BI tool. The readiness for each pillar was rated good if the pillar assessment result reached at least 80 % of expected points. The readiness was moderate if ranging between 50 % and 80 %. The readiness was limited if the rating was below 50%. The readiness status of each country was based on the same criteria. Results: The overall countries’ readiness level to detect and respond to cholera was insufficient. Of the 23 responding countries, there was no country with good readiness. Seven countries had moderate readiness while sixteen had limited readiness level. Laboratory was the best performing pillar with good readiness reported in eight countries. Only three countries had good readiness level for surveillance, two countries for infection prevention and control, and one country respectively for coordination and, water sanitation and hygiene. Conclusion: Countries in the WHO African Region were not adequately prepared to prevent or control cholera outbreak. Such readiness assessment provided critical information about areas of improvement across the 11 pillars and should be regularly undertaken to monitor progress in readiness capacity in the Region.","PeriodicalId":72279,"journal":{"name":"Archives of clinical and biomedical research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69340943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Unnatural Nucleotides: Exploring the Information Storage System of DNA","authors":"A. Yadav, Khushi Khera, K. Kaur, Rekha Mehrotra","doi":"10.26502/acbr.50170306","DOIUrl":"https://doi.org/10.26502/acbr.50170306","url":null,"abstract":"","PeriodicalId":72279,"journal":{"name":"Archives of clinical and biomedical research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69341592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ayman E Abbas, Mohammad Hatem Alrawi, Esra Ali Mahjoub Saeed
{"title":"Assessment of Anterior Abdominal Wall Layers Thickness under the influence of Age and Sex, Using Computed Tomography Imaging in Ibn-Sina Hospital, Khartoum, Sudan 2021","authors":"Ayman E Abbas, Mohammad Hatem Alrawi, Esra Ali Mahjoub Saeed","doi":"10.26502/acbr.50170311","DOIUrl":"https://doi.org/10.26502/acbr.50170311","url":null,"abstract":"","PeriodicalId":72279,"journal":{"name":"Archives of clinical and biomedical research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69341654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
I. Nițu, I. Baciu, S. Găloiu, C. Căpăţană, Iulia Florentina Burcea, Daniela Greere, C. Poiană
{"title":"Clinical Value of NT-proBNP and Performance Myocardial Index as an Echocardiographic Predictor of Early Cardiac Involvement in Patients with Carcinoid Syndrome","authors":"I. Nițu, I. Baciu, S. Găloiu, C. Căpăţană, Iulia Florentina Burcea, Daniela Greere, C. Poiană","doi":"10.26502/acbr.50170284","DOIUrl":"https://doi.org/10.26502/acbr.50170284","url":null,"abstract":"","PeriodicalId":72279,"journal":{"name":"Archives of clinical and biomedical research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69341787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Catană, Enikő Kutasi, Florica Ana Chis, Cristian Popiţa, Sanda Mariela Militaru
{"title":"Kartagener Syndrome Associated with a Family History of Dextrocardia – First Patient to be reported in Romania","authors":"A. Catană, Enikő Kutasi, Florica Ana Chis, Cristian Popiţa, Sanda Mariela Militaru","doi":"10.26502/acbr.50170285","DOIUrl":"https://doi.org/10.26502/acbr.50170285","url":null,"abstract":"","PeriodicalId":72279,"journal":{"name":"Archives of clinical and biomedical research","volume":"43 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69341801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rob E Carpenter, Vaibhav K Tamrakar, Sadia Almas, Emily Brown, Rahul Sharma
Rapid classification and detection of SARS-CoV-2 variants have been critical in comprehending the virus's transmission dynamics. Clinical manifestation of the infection is influenced by comorbidities such as age, immune status, diabetes, and the infecting variant. Thus, clinical management may differ for new variants. For example, some monoclonal antibody treatments are variant-specific. Yet, a U.S. Food and Drug Administration (FDA)-approved test for detecting the SARS-CoV-2 variant is unavailable. A laboratory-developed test (LDT) remains a viable option for reporting the infecting variant for clinical intervention or epidemiological purposes. Accordingly, we have validated the Illumina COVIDSeq assay as an LDT according to the guidelines prescribed by the College of American Pathologists (CAP) and Clinical Laboratory Improvement Amendments (CLIA). The limit of detection (LOD) of this test is Ct<30 (~15 viral copies) and >200X genomic coverage, and the test is 100% specific in the detection of existing variants. The test demonstrated 100% precision in inter-day, intra-day, and intra-laboratory reproducibility studies. It is also 100% accurate, defined by reference strain testing and split sample testing with other CLIA laboratories. Advanta Genetics LDT COVIDSeq has been reviewed by CAP inspectors and is under review by FDA for Emergency Use Authorization.
{"title":"COVIDSeq as Laboratory Developed Test (LDT) for Diagnosis of SARS-CoV-2 Variants of Concern (VOC).","authors":"Rob E Carpenter, Vaibhav K Tamrakar, Sadia Almas, Emily Brown, Rahul Sharma","doi":"10.26502/acbr.50170309","DOIUrl":"https://doi.org/10.26502/acbr.50170309","url":null,"abstract":"<p><p>Rapid classification and detection of SARS-CoV-2 variants have been critical in comprehending the virus's transmission dynamics. Clinical manifestation of the infection is influenced by comorbidities such as age, immune status, diabetes, and the infecting variant. Thus, clinical management may differ for new variants. For example, some monoclonal antibody treatments are variant-specific. Yet, a U.S. Food and Drug Administration (FDA)-approved test for detecting the SARS-CoV-2 variant is unavailable. A laboratory-developed test (LDT) remains a viable option for reporting the infecting variant for clinical intervention or epidemiological purposes. Accordingly, we have validated the Illumina COVIDSeq assay as an LDT according to the guidelines prescribed by the College of American Pathologists (CAP) and <i>Clinical Laboratory Improvement Amendments</i> (CLIA). The limit of detection (LOD) of this test is Ct<30 (~15 viral copies) and >200X genomic coverage, and the test is 100% specific in the detection of existing variants. The test demonstrated 100% precision in inter-day, intra-day, and intra-laboratory reproducibility studies. It is also 100% accurate, defined by reference strain testing and split sample testing with other CLIA laboratories. Advanta Genetics LDT COVIDSeq has been reviewed by CAP inspectors and is under review by FDA for Emergency Use Authorization.</p>","PeriodicalId":72279,"journal":{"name":"Archives of clinical and biomedical research","volume":"6 6","pages":"954-970"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9802674/pdf/nihms-1854775.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10475770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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