A. Clément, S. Alvarez, Laetitia Jacquesson-Fournols
{"title":"Women are More Protected than Men against HHcy (Hyperhomocysteinemia) during their Reproductive Life: Gender-Related Differences in One- Carbon and Folate Cycles Metabolism","authors":"A. Clément, S. Alvarez, Laetitia Jacquesson-Fournols","doi":"10.26502/acbr.50170349","DOIUrl":"https://doi.org/10.26502/acbr.50170349","url":null,"abstract":"","PeriodicalId":72279,"journal":{"name":"Archives of clinical and biomedical research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69341412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Marco Salinas-Pinta, Diana Aguirre, D. I. De la Torre, J. Pérez-Galarza, R. Pibaque, P. Beltrán, T. Veloz, Lucy Baldeón-Rojas
{"title":"Development and Performance Evaluation of a Low-Cost In-House rRTPCR Assay in Ecuador for the Detection of SARS-CoV-2","authors":"Marco Salinas-Pinta, Diana Aguirre, D. I. De la Torre, J. Pérez-Galarza, R. Pibaque, P. Beltrán, T. Veloz, Lucy Baldeón-Rojas","doi":"10.26502/acbr.50170350","DOIUrl":"https://doi.org/10.26502/acbr.50170350","url":null,"abstract":"","PeriodicalId":72279,"journal":{"name":"Archives of clinical and biomedical research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69341450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Siddharth Ghatti, Livvy Ann Yurish, Haiying Shen, K. Rheuban, Kyle B. Enfield, Nikki Reyer Facteau, Gina Engel, Kim Dowdell
Digital twin technology has been increasingly applied in healthcare and patient well-being in recent years. This paper provides an overview of the current methods and applications of digital twins in the healthcare field. One such application is digital twins in precision healthcare, where digital twins are used to create patient-specific models to assist in diagnosis and treatment planning. Digital twins are also used in hospital/clinic management, where they help to optimize resource allocation and workflow processes. In response to the COVID-19 pandemic, digital twins have been utilized to detect outbreaks and predict disease spread. In addition, digital twins have been applied in bio-manufacturing and pharmaceutical industry to improve manufacturing processes. Another application area is machine learning and modeling, where digital twins are used in machine learning, data generation, and system modeling for applications in healthcare and disease prediction. Security and ethical issues related to digital twins are also discussed in this paper, as privacy concerns and data protection remain important considerations in the application of digital twin technology in healthcare. Finally, the paper concludes by discussing the future challenges and directions of future work in this field. These include the need to develop more accurate and sophisticated digital twin models, addressing interoperability and integration issues, and further exploring the potential of digital twin technology in emerging areas such as telemedicine and personalized medicine.
{"title":"Digital Twins in Healthcare: A Survey of Current Methods","authors":"Siddharth Ghatti, Livvy Ann Yurish, Haiying Shen, K. Rheuban, Kyle B. Enfield, Nikki Reyer Facteau, Gina Engel, Kim Dowdell","doi":"10.26502/acbr.50170352","DOIUrl":"https://doi.org/10.26502/acbr.50170352","url":null,"abstract":"Digital twin technology has been increasingly applied in healthcare and patient well-being in recent years. This paper provides an overview of the current methods and applications of digital twins in the healthcare field. One such application is digital twins in precision healthcare, where digital twins are used to create patient-specific models to assist in diagnosis and treatment planning. Digital twins are also used in hospital/clinic management, where they help to optimize resource allocation and workflow processes. In response to the COVID-19 pandemic, digital twins have been utilized to detect outbreaks and predict disease spread. In addition, digital twins have been applied in bio-manufacturing and pharmaceutical industry to improve manufacturing processes. Another application area is machine learning and modeling, where digital twins are used in machine learning, data generation, and system modeling for applications in healthcare and disease prediction. Security and ethical issues related to digital twins are also discussed in this paper, as privacy concerns and data protection remain important considerations in the application of digital twin technology in healthcare. Finally, the paper concludes by discussing the future challenges and directions of future work in this field. These include the need to develop more accurate and sophisticated digital twin models, addressing interoperability and integration issues, and further exploring the potential of digital twin technology in emerging areas such as telemedicine and personalized medicine.","PeriodicalId":72279,"journal":{"name":"Archives of clinical and biomedical research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69341458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Eduardo Gutiérrez-León, R. E. Escamilla Santiago, R. Pacheco-Domínguez, Pablo Martínez- Amezcua, R. Correa-Rotter, M. López Cervantes
{"title":"Utility of Estimated Glomerular Filtration Rate in Hypertensive and Type 2 Diabetic Patients: Results from a Community-Based Study","authors":"Eduardo Gutiérrez-León, R. E. Escamilla Santiago, R. Pacheco-Domínguez, Pablo Martínez- Amezcua, R. Correa-Rotter, M. López Cervantes","doi":"10.26502/acbr.50170346","DOIUrl":"https://doi.org/10.26502/acbr.50170346","url":null,"abstract":"","PeriodicalId":72279,"journal":{"name":"Archives of clinical and biomedical research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69341844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"High Seroprevalence of Dengue Virus Ns1 in HIV-1 Infected Children Suggests Impaired Immune Response to Pediatric Dengue Virus Infection","authors":"J. Tchadji, Loveline Ngu Ndengkoh","doi":"10.26502/acbr.50170365","DOIUrl":"https://doi.org/10.26502/acbr.50170365","url":null,"abstract":"","PeriodicalId":72279,"journal":{"name":"Archives of clinical and biomedical research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69342058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Lepillier, X. Copie, W. Escande, M. Niro, O. Paziaud, O. Piot
{"title":"eterogeneity of Low Voltage Areas Spatial Distribution in Sinus Rhythm during Electroanatomic Mapping of Persistent Atrial Fibrillation","authors":"A. Lepillier, X. Copie, W. Escande, M. Niro, O. Paziaud, O. Piot","doi":"10.26502/fccm.92920322","DOIUrl":"https://doi.org/10.26502/fccm.92920322","url":null,"abstract":"","PeriodicalId":72279,"journal":{"name":"Archives of clinical and biomedical research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69347026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Human nuclear receptors (NRs) involve 49 ligand-dependent transcription factors that are important for regulating the cell cycle and processes. There are many literature references on NR expression in many organs, abnormal cells, and tissues. However, a simple universal method to study the expression of NR is still missing. Here, we present systematic profiling of NRs in human umbilical cord stem cell lines and assess the expression of the 49 human NRs by quantitative real-time (qRT)-PCR using Metadichol, a nanoemulsion made of natural lipid alcohol. Metadicholtreated umbilical cord cells and fibroblasts, where all cells expressed NRs at a concentration range of 1 picogram per ml to 100 ng per ml in a dose dependent manner, were detected by qRT-PCR and qualified by Western blotting. This method will allow the study of many organs and tissues and expand our understanding of the role of NRs in mitigating diseases.
人类核受体(NRs)涉及49种配体依赖性转录因子，这些转录因子在调节细胞周期和过程中起重要作用。关于NR在许多器官、异常细胞和组织中的表达有很多文献报道。然而，目前尚缺乏一种简单通用的研究NR表达的方法。在这里，我们系统地分析了人脐带干细胞系中的NRs，并使用Metadichol(一种由天然脂质醇制成的纳米乳)通过定量实时(qRT)-PCR评估了49种人NRs的表达。用qRT-PCR检测经metadicholter处理的脐带细胞和成纤维细胞，其中所有细胞以剂量依赖的方式表达NRs，浓度范围为1 picogram / ml至100 ng / ml，并通过Western blotting鉴定。这种方法将允许研究许多器官和组织，并扩大我们对nr在减轻疾病中的作用的理解。
{"title":"Metadichol® A Nano Lipid Emulsion that Expresses All 49 Nuclear Receptors in Stem and Somatic Cells","authors":"Palayakotai R. Raghavan","doi":"10.26502/acbr.50170370","DOIUrl":"https://doi.org/10.26502/acbr.50170370","url":null,"abstract":"Human nuclear receptors (NRs) involve 49 ligand-dependent transcription factors that are important for regulating the cell cycle and processes. There are many literature references on NR expression in many organs, abnormal cells, and tissues. However, a simple universal method to study the expression of NR is still missing. Here, we present systematic profiling of NRs in human umbilical cord stem cell lines and assess the expression of the 49 human NRs by quantitative real-time (qRT)-PCR using Metadichol, a nanoemulsion made of natural lipid alcohol. Metadicholtreated umbilical cord cells and fibroblasts, where all cells expressed NRs at a concentration range of 1 picogram per ml to 100 ng per ml in a dose dependent manner, were detected by qRT-PCR and qualified by Western blotting. This method will allow the study of many organs and tissues and expand our understanding of the role of NRs in mitigating diseases.","PeriodicalId":72279,"journal":{"name":"Archives of clinical and biomedical research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135211182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.22491/2357-9730.125718
Andriele do Prado Mello, Laura Vicedo Jacociunas
A enxaqueca crônica é causada por alterações químicas do cérebro, dores unilaterais, pulsáteis de intensidade variável. A administração da toxina botulínica, neurotoxina produzida peloClostridium botulinum, é uma alternativa de tratamento. Existem diferentes preparações da toxina botulínica, capaz de inibir a liberação de acetilcolina, provocando uma inibição da contração muscular. O objetivo do estudo foi analisar a eficácia terapêutica da toxina botulínica no tratamento da enxaqueca crônica. Foi realizada uma revisão sistemática utilizando como ferramenta embasadora o método de Principais Itens para Relatar Revisões Sistemáticas e Meta-Análises, utilizando como descritores: enxaqueca crônica, toxina botulínica e tratamento. Foram analisados 21 artigos, sendo 6 metas-analises e 15 ensaios clínicos, 9 ensaios clínicos foram comparados a placebo e 6 a outras terapias. Os ensaios utilizaram uma variedade de doses de 75 até 260 UI, e incluíram pacientes com enxaqueca episódica e crônica, na qual a toxina mostrou maior eficácia. A toxina apresentou também um perfil bom de segurança, sendo relatados poucos efeitos adversos, que em geral foram leves ou moderados. O estudo concluiu que ensaios clínicos controlados indicam que a toxina botulínica tipo A foi eficaz no tratamento da enxaqueca crônica. Na comparação com os demais medicamentos demostrou eficácia semelhante perfil de tolerabilidade superior.
{"title":"Toxina Botulínica no Tratamento da Enxaqueca Crônica: Uma revisão sistemática","authors":"Andriele do Prado Mello, Laura Vicedo Jacociunas","doi":"10.22491/2357-9730.125718","DOIUrl":"https://doi.org/10.22491/2357-9730.125718","url":null,"abstract":"A enxaqueca crônica é causada por alterações químicas do cérebro, dores unilaterais, pulsáteis de intensidade variável. A administração da toxina botulínica, neurotoxina produzida peloClostridium botulinum, é uma alternativa de tratamento. Existem diferentes preparações da toxina botulínica, capaz de inibir a liberação de acetilcolina, provocando uma inibição da contração muscular. O objetivo do estudo foi analisar a eficácia terapêutica da toxina botulínica no tratamento da enxaqueca crônica. Foi realizada uma revisão sistemática utilizando como ferramenta embasadora o método de Principais Itens para Relatar Revisões Sistemáticas e Meta-Análises, utilizando como descritores: enxaqueca crônica, toxina botulínica e tratamento. Foram analisados 21 artigos, sendo 6 metas-analises e 15 ensaios clínicos, 9 ensaios clínicos foram comparados a placebo e 6 a outras terapias. Os ensaios utilizaram uma variedade de doses de 75 até 260 UI, e incluíram pacientes com enxaqueca episódica e crônica, na qual a toxina mostrou maior eficácia. A toxina apresentou também um perfil bom de segurança, sendo relatados poucos efeitos adversos, que em geral foram leves ou moderados. O estudo concluiu que ensaios clínicos controlados indicam que a toxina botulínica tipo A foi eficaz no tratamento da enxaqueca crônica. Na comparação com os demais medicamentos demostrou eficácia semelhante perfil de tolerabilidade superior.","PeriodicalId":72279,"journal":{"name":"Archives of clinical and biomedical research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135843630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.22491/2357-9730.130518
Gerson Pires Dorneles, Lisandra Sanzi Aquino, Alexandre Simões Dias
O uso de tecnologias móveis e sem fio para apoiar a realização dos objetivos de saúde é uma tendência dentro da e-saúde. Existem lacunas de conhecimento adicionais no uso emergente de smartphones para a gestão e monitoramento de doenças crônicas como o acidente vascular cerebral, principalmente dentro do ambiente hospitalar. O objetivo deste estudo foi o de revisar os estudos que utilizaram aplicativos móveis para a gestão de pacientes hospitalizados com acidente vascular cerebral. Esta revisão sistemática seguiu as recomendações preconizadas pelo Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA), sendo realizada nas bases de dados eletrônicas Medline/PubMed e Embase, além de busca manual às referências de estudos já publicados sobre o assunto. Foram encontrados 207 estudos e após análise dos critérios de inclusão e exclusão, 6 foram incluídos para análise completa. O uso de aplicativos móveis pode acelerar o tempo de atendimento de pacientes internados com acidente vascular cerebral, diminuindo a morte neuronal, melhorando a mortalidade hospitalar, diminuindo a hemorragia intracraniana e contribuindo para um retorno precoce para a casa dos pacientes.
{"title":"Aplicativos móveis desenvolvidos para a gestão intra-hospitalar de pacientes com acidente vascular cerebral: uma revisão sistemática","authors":"Gerson Pires Dorneles, Lisandra Sanzi Aquino, Alexandre Simões Dias","doi":"10.22491/2357-9730.130518","DOIUrl":"https://doi.org/10.22491/2357-9730.130518","url":null,"abstract":"O uso de tecnologias móveis e sem fio para apoiar a realização dos objetivos de saúde é uma tendência dentro da e-saúde. Existem lacunas de conhecimento adicionais no uso emergente de smartphones para a gestão e monitoramento de doenças crônicas como o acidente vascular cerebral, principalmente dentro do ambiente hospitalar. O objetivo deste estudo foi o de revisar os estudos que utilizaram aplicativos móveis para a gestão de pacientes hospitalizados com acidente vascular cerebral. Esta revisão sistemática seguiu as recomendações preconizadas pelo Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA), sendo realizada nas bases de dados eletrônicas Medline/PubMed e Embase, além de busca manual às referências de estudos já publicados sobre o assunto. Foram encontrados 207 estudos e após análise dos critérios de inclusão e exclusão, 6 foram incluídos para análise completa. O uso de aplicativos móveis pode acelerar o tempo de atendimento de pacientes internados com acidente vascular cerebral, diminuindo a morte neuronal, melhorando a mortalidade hospitalar, diminuindo a hemorragia intracraniana e contribuindo para um retorno precoce para a casa dos pacientes.","PeriodicalId":72279,"journal":{"name":"Archives of clinical and biomedical research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135844286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Felice Civitillo, F. Barcos-Muñoz, A. Bordessoule, O. Karam
{"title":"Atypical Postnatal Hemorrhage in a Hemophilic Newborn: A Case Report and Parents’ Perspective Seven Years Later","authors":"Felice Civitillo, F. Barcos-Muñoz, A. Bordessoule, O. Karam","doi":"10.26502/acbr.50170313","DOIUrl":"https://doi.org/10.26502/acbr.50170313","url":null,"abstract":"","PeriodicalId":72279,"journal":{"name":"Archives of clinical and biomedical research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69341668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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