M. Marghoob, U. Saeed, Zahra Zahid Piracha, Haiqa Shafiq, Noor e Fatima, Nimra Sarfraz, Noor Farooq, R. Uppal
With COVID 19 becoming a most important worldwide cause of concern, it is significant to comprehend the various manifestations of the disease to fully accomplish it. No country is untouched by the plague of this new disease which was first reported from Wuhan, China in December 2019. It is an infectious disease caused by novel coronavirus i-e; SARS-CoV-2. The rapid spread of this disease as well as the illness and mortality associated with this disease has led to unprecedented research into the various aspects of this disease. While respiratory catalogs are the most predominant feature of this disease, with time it has been initiate that the virus can include almost any organ in the human body. Covid-19 has overcome human wellbeing worldwide while also vigorously affecting the worldwide economy. SARS-CoV-2 has influenced more than 220 nations and domains, with roughly 4176,185 deaths so far across the globe. Recently, Mucormycosis made serious disarray in India during the second wave (among April and June 2021) of the tragical COVID-19 upsurge by its startling and severe overflow with up to half the death rate. Mucormycosis is a deadly parasitic infection brought about by a kind of uncommon yet deft contagious microorganism called mucormycetes. While the specific reason for its sharp ascent out of nowhere and explicitly during the second wave stays disputable, it has been noticed that individuals who are diabetic and have recuperated from COVID-19 Arch Clin Biomed Res 2021; 6 (1): 41-49 DOI: 10.26502/acbr.50170224 Archives of Clinical and Biomedical Research Vol. 6 No. 1 – February 2022. [ISSN 2572-9292]. 42 disease are more inclined to Mucormycosis. In this review, we will briefly discuss the relation between COVID-19 and Mucormycosis.
{"title":"SARS-CoV-2 Infection and Incidence of Mucormycosis","authors":"M. Marghoob, U. Saeed, Zahra Zahid Piracha, Haiqa Shafiq, Noor e Fatima, Nimra Sarfraz, Noor Farooq, R. Uppal","doi":"10.26502/acbr.50170224","DOIUrl":"https://doi.org/10.26502/acbr.50170224","url":null,"abstract":"With COVID 19 becoming a most important worldwide cause of concern, it is significant to comprehend the various manifestations of the disease to fully accomplish it. No country is untouched by the plague of this new disease which was first reported from Wuhan, China in December 2019. It is an infectious disease caused by novel coronavirus i-e; SARS-CoV-2. The rapid spread of this disease as well as the illness and mortality associated with this disease has led to unprecedented research into the various aspects of this disease. While respiratory catalogs are the most predominant feature of this disease, with time it has been initiate that the virus can include almost any organ in the human body. Covid-19 has overcome human wellbeing worldwide while also vigorously affecting the worldwide economy. SARS-CoV-2 has influenced more than 220 nations and domains, with roughly 4176,185 deaths so far across the globe. Recently, Mucormycosis made serious disarray in India during the second wave (among April and June 2021) of the tragical COVID-19 upsurge by its startling and severe overflow with up to half the death rate. Mucormycosis is a deadly parasitic infection brought about by a kind of uncommon yet deft contagious microorganism called mucormycetes. While the specific reason for its sharp ascent out of nowhere and explicitly during the second wave stays disputable, it has been noticed that individuals who are diabetic and have recuperated from COVID-19 Arch Clin Biomed Res 2021; 6 (1): 41-49 DOI: 10.26502/acbr.50170224 Archives of Clinical and Biomedical Research Vol. 6 No. 1 – February 2022. [ISSN 2572-9292]. 42 disease are more inclined to Mucormycosis. In this review, we will briefly discuss the relation between COVID-19 and Mucormycosis.","PeriodicalId":72279,"journal":{"name":"Archives of clinical and biomedical research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69339927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
V. Papaioannou, K. Budohoski, Michał M. Placek, Z. Czosnyka, P. Smielewski, M. Czosnyka
Background: In patients suffering from Subarachnoid Hemorrhage (SAH), Delayed Cerebral Ischemia (DCI) is partly associated with Vasospasm (VS) and impaired cerebral autoregulation. We investigated the pattern of changes of different Transcranial Doppler (TCD)-derived indices of cerebrovascular dynamics during VS, in patients dichotomized by the presence of DCI. Methods: A retrospective analysis was performed using recordings from 32 SAH patients, diagnosed with VS through bilateral TCD measurements. Patients were divided in 2 groups, depending on development of DCI. Cerebral autoregulation was estimated using the moving correlation coefficient Mxa, calculated from spontaneous fluctuations of Cerebral Blood Flow Velocity (CBFV) and Arterial Blood Pressure (ABP). We also measured cerebral arterial time constant (tau) as the product of resistance (Ra) and Compliance (Ca) and Critical Closing Pressure (CrCP), using two different methods of assessment (CrCPAaslid and CrCPVarsos). Results: In the whole population (N=32), VS caused shortening of tau (ipsilateral to spasm: 0.17 ± 0.08 vs before: 0.25 ± 0.17 sec, p = 0.04), decrease in CrCPAaslid (ipsilateral to spasm: 9.69 ± 23.28 vs before: 27.23 ± 23.31 mmHg, p = 0.01) and interhemispheric asymmetry with lower values on ipsilateral side (p < 0.01). Ipsilateral CrCPAaslid during VS was negatively correlated with Mxa (r =-0.43, p=0.01), whereas CrCPVarsos exhibited positive correlation with tau (r=0.74, p < 0.001). In patients with DCI (N=19), VS caused increase in Mxa (ipsilateral to spasm: 0.36 ± 0.18 vs before: 0.26 ± 0.23, p = 0.04), decrease in CrCPAaslid (ipsilateral to spasm: 6.61 ± 24.5 vs before: 17.24 ± 19.4 mmHg, p = 0.04) and lower values on ipsilateral side (p < 0.01). Arch Clin Biomed Res 2022; 6 (1): 119-133 DOI: 10.26502/acbr.50170230 Archives of Clinical and Biomedical Research Vol. 6 No. 1 – February 2022. [ISSN 2572-9292]. 120 Conclusions: During VS, tau and CrCP were reduced in both temporal and spatial assessments, whereas DCI was associated with loss of autoregulation and vasoparalysis.
背景:在蛛网膜下腔出血(SAH)患者中，延迟性脑缺血(DCI)与血管痉挛(VS)和大脑自动调节功能受损部分相关。我们研究了经颅多普勒(TCD)衍生的不同脑血管动力学指标在VS期间的变化模式，在DCI存在的患者中。方法:回顾性分析32例SAH患者的记录，通过双侧TCD测量诊断为VS。根据DCI的发展情况将患者分为两组。根据脑血流速度(CBFV)和动脉血压(ABP)的自发波动计算的运动相关系数Mxa估计脑自动调节。我们还使用两种不同的评估方法(CrCPAaslid和CrCPVarsos)测量了脑动脉时间常数(tau)作为阻力(Ra)和顺应性(Ca)和临界闭合压(CrCP)的乘积。结果:在所有人群中(N=32)， VS引起tau缩短(同侧痉挛:0.17±0.08 VS前:0.25±0.17 sec, p = 0.04)， CrCPAaslid降低(同侧痉挛:9.69±23.28 VS前:27.23±23.31 mmHg, p = 0.01)和半球间不对称(同侧较低)(p < 0.01)。VS时同侧crcppaaslid与Mxa呈负相关(r= -0.43, p=0.01)，而CrCPVarsos与tau呈正相关(r=0.74, p < 0.001)。在DCI患者(N=19)中，VS导致Mxa升高(同侧痉挛:0.36±0.18 VS前:0.26±0.23,p = 0.04)， CrCPAaslid降低(同侧痉挛:6.61±24.5 VS前:17.24±19.4 mmHg, p = 0.04)，同侧降低(p < 0.01)。Arch clinn Biomed Res 2022;6 (1): 119-133 DOI: 10.26502/acbr.50170230临床和生物医学研究档案第6卷第1期- 2022年2月。(ISSN 2572 - 9292)。120结论:在VS期间，tau和CrCP在时间和空间评估中都降低，而DCI与自我调节丧失和血管麻痹有关。
{"title":"Relation between Mean Velocity Index, Time Constant and Critical Closing Pressure in Patients with Subarachnoid Hemorrhage","authors":"V. Papaioannou, K. Budohoski, Michał M. Placek, Z. Czosnyka, P. Smielewski, M. Czosnyka","doi":"10.26502/acbr.50170230","DOIUrl":"https://doi.org/10.26502/acbr.50170230","url":null,"abstract":"Background: In patients suffering from Subarachnoid Hemorrhage (SAH), Delayed Cerebral Ischemia (DCI) is partly associated with Vasospasm (VS) and impaired cerebral autoregulation. We investigated the pattern of changes of different Transcranial Doppler (TCD)-derived indices of cerebrovascular dynamics during VS, in patients dichotomized by the presence of DCI. Methods: A retrospective analysis was performed using recordings from 32 SAH patients, diagnosed with VS through bilateral TCD measurements. Patients were divided in 2 groups, depending on development of DCI. Cerebral autoregulation was estimated using the moving correlation coefficient Mxa, calculated from spontaneous fluctuations of Cerebral Blood Flow Velocity (CBFV) and Arterial Blood Pressure (ABP). We also measured cerebral arterial time constant (tau) as the product of resistance (Ra) and Compliance (Ca) and Critical Closing Pressure (CrCP), using two different methods of assessment (CrCPAaslid and CrCPVarsos). Results: In the whole population (N=32), VS caused shortening of tau (ipsilateral to spasm: 0.17 ± 0.08 vs before: 0.25 ± 0.17 sec, p = 0.04), decrease in CrCPAaslid (ipsilateral to spasm: 9.69 ± 23.28 vs before: 27.23 ± 23.31 mmHg, p = 0.01) and interhemispheric asymmetry with lower values on ipsilateral side (p < 0.01). Ipsilateral CrCPAaslid during VS was negatively correlated with Mxa (r =-0.43, p=0.01), whereas CrCPVarsos exhibited positive correlation with tau (r=0.74, p < 0.001). In patients with DCI (N=19), VS caused increase in Mxa (ipsilateral to spasm: 0.36 ± 0.18 vs before: 0.26 ± 0.23, p = 0.04), decrease in CrCPAaslid (ipsilateral to spasm: 6.61 ± 24.5 vs before: 17.24 ± 19.4 mmHg, p = 0.04) and lower values on ipsilateral side (p < 0.01). Arch Clin Biomed Res 2022; 6 (1): 119-133 DOI: 10.26502/acbr.50170230 Archives of Clinical and Biomedical Research Vol. 6 No. 1 – February 2022. [ISSN 2572-9292]. 120 Conclusions: During VS, tau and CrCP were reduced in both temporal and spatial assessments, whereas DCI was associated with loss of autoregulation and vasoparalysis.","PeriodicalId":72279,"journal":{"name":"Archives of clinical and biomedical research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69340110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: Liraglutide are associated with a decreased risk of fracture among Type 2 Diabetes Mellitus Patients (T2DM) but the mechanism is unclear, the effect of liraglutide on Bone Mineral Density (BMD) and Bone Turnover Markers (BTMs) were taken into consideration. Method: We searched for randomized controlled trials of liraglutide in PubMed, Embase, the Cochrane Library, Web of Science, CNKI and VIP database up to October 2021. Heterogeneity among studies was examined by Cochrane Q test. Results: 7 pieces of eligible literature involving 478 patients were divided into the liraglutide treatment group (n = 241) and control group (n = 237) in this meta-analysis. Based on fixed effect model, liraglutide had no beneficial Arch Clin Biomed Res 2022; 6 (1): 134-144 DOI: 10.26502/acbr.50170231 Archives of Clinical and Biomedical Research Vol. 6 No. 1 – February 2022. [ISSN 2572-9292]. 135 effect on BMD (MD: 0.00; 95% CI: (-0.01, 0.02); p=0.69, I2=0%), but there were significant increase effects of liraglutide on bone gla protein (BGP, MD: 0.63; 95% CI: (0.23, 1.03); p=0.002, I2=36%), Bone specific alkaline phosphatase (BAP, MD: 0.85; 95% CI: (0.30, 1.40); p=0.002, I2=23%) and PINP (MD: 6.90; 95%CI: (5.71, 8.09); p =0.002) compared to conventional treatment. Moreover, liraglutide decrease serum β cross-linked C-telopeptide of type I collagen (β-CTX, MD: 0.03; 95%CI: (0.01, 0.05); p = 0.0005, I2 =0%). Conclusions: This meta-analysis demonstrated that liraglutide significantly increae OC, BAP, PINP and reduce βCTX content compared to conventional treatment in T2DM patients, but the difference was no beneficial effect on BMD. This finding may provide additional evidence for the use of liraglutide to improve skeletal health in T2DM patients.
{"title":"The Effects of Glucagon-Like Peptide-1 Receptor Agonists of Liraglutide on Bone Turnover Makers Among Type 2 Diabetes Mellitus Patients: A Meta-Analysis of Randomized Controlled Trials","authors":"Jing Kang, Sha Lei, Jinlan Guan","doi":"10.26502/acbr.50170231","DOIUrl":"https://doi.org/10.26502/acbr.50170231","url":null,"abstract":"Objective: Liraglutide are associated with a decreased risk of fracture among Type 2 Diabetes Mellitus Patients (T2DM) but the mechanism is unclear, the effect of liraglutide on Bone Mineral Density (BMD) and Bone Turnover Markers (BTMs) were taken into consideration. Method: We searched for randomized controlled trials of liraglutide in PubMed, Embase, the Cochrane Library, Web of Science, CNKI and VIP database up to October 2021. Heterogeneity among studies was examined by Cochrane Q test. Results: 7 pieces of eligible literature involving 478 patients were divided into the liraglutide treatment group (n = 241) and control group (n = 237) in this meta-analysis. Based on fixed effect model, liraglutide had no beneficial Arch Clin Biomed Res 2022; 6 (1): 134-144 DOI: 10.26502/acbr.50170231 Archives of Clinical and Biomedical Research Vol. 6 No. 1 – February 2022. [ISSN 2572-9292]. 135 effect on BMD (MD: 0.00; 95% CI: (-0.01, 0.02); p=0.69, I2=0%), but there were significant increase effects of liraglutide on bone gla protein (BGP, MD: 0.63; 95% CI: (0.23, 1.03); p=0.002, I2=36%), Bone specific alkaline phosphatase (BAP, MD: 0.85; 95% CI: (0.30, 1.40); p=0.002, I2=23%) and PINP (MD: 6.90; 95%CI: (5.71, 8.09); p =0.002) compared to conventional treatment. Moreover, liraglutide decrease serum β cross-linked C-telopeptide of type I collagen (β-CTX, MD: 0.03; 95%CI: (0.01, 0.05); p = 0.0005, I2 =0%). Conclusions: This meta-analysis demonstrated that liraglutide significantly increae OC, BAP, PINP and reduce βCTX content compared to conventional treatment in T2DM patients, but the difference was no beneficial effect on BMD. This finding may provide additional evidence for the use of liraglutide to improve skeletal health in T2DM patients.","PeriodicalId":72279,"journal":{"name":"Archives of clinical and biomedical research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69340167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kayser F, Bori E, Armillotta N, Innocenti B, Hontoir F, V. Jm
Citation: Kayser F, Bori E, Armillotta N, Innocenti B, Hontoir F, Vandeweerd JM. Correlation between Shear Wave Velocity Assessed by Elastography and Stiffness given by Tensile Test in the Ovine Patellar Tendon. Archives of Clinical and Biomedical Research 6 (2022): 248-259. Abstract Background: Tendon injuries are very common in man, healing process often slow and incomplete, and available treatment options unsatisfactory. Mechanical properties such as stiffness can reflect the progress of tissue healing over time. Unfortunately, these measures cannot be recorded in vivo due to the invasive nature of the available conventional biomechanical testing methods. SWE can be used in vivo to investigate mechanical properties of tendons. Material and methods: Twelve patellar tendons in six healthy ewes underwent conventional ultrasound, color Doppler ultrasound and SWE in vivo followed by uniaxial testing performed ex vivo . Results: The mean stiffness value of the 12 tendons was 45.69 N/mm (SD+/- 14.56). The mean shear wave velocity was 6.27 m/s (SD+/-0.6). There was a not statistically significant positive correlation between shear wave velocity and age (r=0.137, p=0.79), and a significant positive correlation between stiffness and SWV (r=0.87; p=0.02). Conclusion: SWE can be a surrogate to biomechanical properties of the tendon with the advantage that it can be performed in vivo . It could be a useful imaging tool in the context of disease progression and healing follow-up. The SWV values obtained in our study could be considered as baseline values for further research studies on patellar tendons in the ovine model.
引用本文:Kayser F, Bori E, Armillotta N, Innocenti B, Hontoir F, Vandeweerd JM。羊髌骨肌腱剪切波速与拉伸试验刚度的相关性研究。临床与生物医学研究档案6(2022):248-259。摘要背景:肌腱损伤在男性中非常常见，愈合过程往往缓慢且不完整，现有的治疗方案令人不满意。机械性能如硬度可以反映组织愈合的进展。不幸的是，由于现有的传统生物力学测试方法的侵入性，这些测量不能在体内记录。SWE可以在体内用于研究肌腱的力学特性。材料与方法:对6只健康母羊的12条髌骨肌腱进行体内常规超声、彩色多普勒超声和SWE检查，并在体外进行单轴检查。结果:12根肌腱的平均刚度值为45.69 N/mm (SD±14.56)。平均横波速度为6.27 m/s (SD+/-0.6)。横波速度与年龄呈正相关(r=0.137, p=0.79)，而刚度与SWV呈正相关(r=0.87;p = 0.02)。结论:SWE可以代替肌腱的生物力学性能，并且可以在体内进行。它可能是一个有用的成像工具，在疾病进展和愈合随访的背景下。本研究获得的SWV值可作为进一步研究羊模型髌骨肌腱的基线值。
{"title":"Correlation between Shear Wave Velocity Assessed by Elastography and Stiffness given by Tensile Test in the Ovine Patellar Tendon","authors":"Kayser F, Bori E, Armillotta N, Innocenti B, Hontoir F, V. Jm","doi":"10.26502/acbr.50170240","DOIUrl":"https://doi.org/10.26502/acbr.50170240","url":null,"abstract":"Citation: Kayser F, Bori E, Armillotta N, Innocenti B, Hontoir F, Vandeweerd JM. Correlation between Shear Wave Velocity Assessed by Elastography and Stiffness given by Tensile Test in the Ovine Patellar Tendon. Archives of Clinical and Biomedical Research 6 (2022): 248-259. Abstract Background: Tendon injuries are very common in man, healing process often slow and incomplete, and available treatment options unsatisfactory. Mechanical properties such as stiffness can reflect the progress of tissue healing over time. Unfortunately, these measures cannot be recorded in vivo due to the invasive nature of the available conventional biomechanical testing methods. SWE can be used in vivo to investigate mechanical properties of tendons. Material and methods: Twelve patellar tendons in six healthy ewes underwent conventional ultrasound, color Doppler ultrasound and SWE in vivo followed by uniaxial testing performed ex vivo . Results: The mean stiffness value of the 12 tendons was 45.69 N/mm (SD+/- 14.56). The mean shear wave velocity was 6.27 m/s (SD+/-0.6). There was a not statistically significant positive correlation between shear wave velocity and age (r=0.137, p=0.79), and a significant positive correlation between stiffness and SWV (r=0.87; p=0.02). Conclusion: SWE can be a surrogate to biomechanical properties of the tendon with the advantage that it can be performed in vivo . It could be a useful imaging tool in the context of disease progression and healing follow-up. The SWV values obtained in our study could be considered as baseline values for further research studies on patellar tendons in the ovine model.","PeriodicalId":72279,"journal":{"name":"Archives of clinical and biomedical research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69340472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K. Kontoangelos, G. Poulakou, M. Economou, K. Leontis, P. Fragkou, I. Baraboutis, V. Rapti, E. Tsagalou, Konstantinos Koufatzidis, S. Sympardi, K. Argyraki, P. Panagopoulos, G. Latsios, Christos Papageorgiou, Sofia Tsiori, S. Tsiodras, M. Dimopoulos, K. Syrigos, C. Papageorgiou
Objective: Coronavirus disease (COVID-19) was first reported in Wuhan, China, in December 2019. Since then, it has been rapidly spreading throughout the world. Healthcare workers serve at the forefront of infectious diseases to provide care to patients. A lack of therapeutic agents and vaccines for COVID-19 has exacerbated the fear and burden experienced by hospital workers. Methods: The sample consisted of 204 health workers (internists, cardiologists, pneumonologists, oncologists, nurses) 117 male and 87 female: During the initial evaluation, all the participants were assessed with the following psychometric questionnaires: A. The SCL -90 scale B. The Greek version of the Cambridge Depersonalization Scale and C. the Greek version of the Davidson Trauma Scale (DTS). Results: The scales of CDS (r = 0.509, r=0.456, p<0.001) and DTS (r = 0.482, r=0.408, p<0.001) are highly correlated with the scale of somatization. The SCL-90 scale of obsessive-compulsive is highly correlated with both scales of DTS (r = 0.273, p<0.001 and r=0.184, p<0.001). Depression is highly correlated with both scales of CDS (r = 0.315, r=0.276, p<0.001) and DTS (r = 0.452, r=0.352, p<0.001). Discussion: Health professionals must deal with possible psychological, work-related consequences during the COVID-19 crisis, such as posttraumatic stress, anxiety, depression or depersonalization. Preventive measures to reduce the psychological effect of pandemia should be implemented for these health workers.
{"title":"Ptsd, Depersonalization and Psychosomatic Symptoms in Health Care Workers During the Covid-19 Outbreak","authors":"K. Kontoangelos, G. Poulakou, M. Economou, K. Leontis, P. Fragkou, I. Baraboutis, V. Rapti, E. Tsagalou, Konstantinos Koufatzidis, S. Sympardi, K. Argyraki, P. Panagopoulos, G. Latsios, Christos Papageorgiou, Sofia Tsiori, S. Tsiodras, M. Dimopoulos, K. Syrigos, C. Papageorgiou","doi":"10.26502/acbr.50170254","DOIUrl":"https://doi.org/10.26502/acbr.50170254","url":null,"abstract":"Objective: Coronavirus disease (COVID-19) was first reported in Wuhan, China, in December 2019. Since then, it has been rapidly spreading throughout the world. Healthcare workers serve at the forefront of infectious diseases to provide care to patients. A lack of therapeutic agents and vaccines for COVID-19 has exacerbated the fear and burden experienced by hospital workers. Methods: The sample consisted of 204 health workers (internists, cardiologists, pneumonologists, oncologists, nurses) 117 male and 87 female: During the initial evaluation, all the participants were assessed with the following psychometric questionnaires: A. The SCL -90 scale B. The Greek version of the Cambridge Depersonalization Scale and C. the Greek version of the Davidson Trauma Scale (DTS). Results: The scales of CDS (r = 0.509, r=0.456, p<0.001) and DTS (r = 0.482, r=0.408, p<0.001) are highly correlated with the scale of somatization. The SCL-90 scale of obsessive-compulsive is highly correlated with both scales of DTS (r = 0.273, p<0.001 and r=0.184, p<0.001). Depression is highly correlated with both scales of CDS (r = 0.315, r=0.276, p<0.001) and DTS (r = 0.452, r=0.352, p<0.001). Discussion: Health professionals must deal with possible psychological, work-related consequences during the COVID-19 crisis, such as posttraumatic stress, anxiety, depression or depersonalization. Preventive measures to reduce the psychological effect of pandemia should be implemented for these health workers.","PeriodicalId":72279,"journal":{"name":"Archives of clinical and biomedical research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69340495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Meltem Songur Kodik, Esin Ozturk, Y. Altuncı, E. Ozçete, S. Yalçınlı, M. Ersel, Deniz Akyol, S. Bayraktaroğlu, O. Goksel, Ahmet Enes Celik
{"title":"Survival Patterns of COVID-19 Pneumonia Patients with False-Negative PCR Results Transferred to the Intensive Care Unit from the Emergency Department","authors":"Meltem Songur Kodik, Esin Ozturk, Y. Altuncı, E. Ozçete, S. Yalçınlı, M. Ersel, Deniz Akyol, S. Bayraktaroğlu, O. Goksel, Ahmet Enes Celik","doi":"10.26502/acbr.50170258","DOIUrl":"https://doi.org/10.26502/acbr.50170258","url":null,"abstract":"","PeriodicalId":72279,"journal":{"name":"Archives of clinical and biomedical research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69340553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rodolfo Augusto Alves Pedrão, R. Riella, S. Valderramas
Objective: To assess the characteristics and quality of sleep in critically ill older and younger adults and verify the differences between these groups. Check for associations between sleep and the perception of pain, noise, temperature, environmental luminance and the use of opiods and benzodiazepines. Method: Cross-sectional observational study, which evaluated lucid critically ill individuals, older and younger adults, with diseases of low or moderate severity. Sleep characteristics were measured using the Bispectral Index; sleep quality was measured using the Richards-Campbell Sleep Questionnaire; pain level was measured by Visual-Analog Scale; we recorded the ambient sound pressure, luminance and temperature, as well as the administered doses of opiods and benzodiazepines. Results: The medians of total sleep time, deep sleep time, pain intensity, luminance, ambient temperature, continuous sound pressure equivalent and perceived sleep quality were 237 minutes, 0 minutes, 1/10 point, 13.26 Lux, 22.4ºC, 57.27 decibels and 61/100 points, respectively. No older participant achieved deep sleep. In older people, pain and sleep quality are inversely correlated (ρ = -.48; p <.05); in younger adults, volume and time of deep sleep were inversely correlated with environmental noise (ρ = -.45; p<.05 and ρ = -.44; p<.05, respectively). Conclusion: The sleep of adult patients with low and medium severity illnesses admitted to the ICU is of short duration and superficial, especially in the older patients. In these, pain perception is inversely correlated with sleep quality, while, in younger adults, environmental noise is inversely correlated with deep sleep.
{"title":"The Sleep in the Critically Ill Aged Patients","authors":"Rodolfo Augusto Alves Pedrão, R. Riella, S. Valderramas","doi":"10.26502/acbr.50170274","DOIUrl":"https://doi.org/10.26502/acbr.50170274","url":null,"abstract":"Objective: To assess the characteristics and quality of sleep in critically ill older and younger adults and verify the differences between these groups. Check for associations between sleep and the perception of pain, noise, temperature, environmental luminance and the use of opiods and benzodiazepines. Method: Cross-sectional observational study, which evaluated lucid critically ill individuals, older and younger adults, with diseases of low or moderate severity. Sleep characteristics were measured using the Bispectral Index; sleep quality was measured using the Richards-Campbell Sleep Questionnaire; pain level was measured by Visual-Analog Scale; we recorded the ambient sound pressure, luminance and temperature, as well as the administered doses of opiods and benzodiazepines. Results: The medians of total sleep time, deep sleep time, pain intensity, luminance, ambient temperature, continuous sound pressure equivalent and perceived sleep quality were 237 minutes, 0 minutes, 1/10 point, 13.26 Lux, 22.4ºC, 57.27 decibels and 61/100 points, respectively. No older participant achieved deep sleep. In older people, pain and sleep quality are inversely correlated (ρ = -.48; p <.05); in younger adults, volume and time of deep sleep were inversely correlated with environmental noise (ρ = -.45; p<.05 and ρ = -.44; p<.05, respectively). Conclusion: The sleep of adult patients with low and medium severity illnesses admitted to the ICU is of short duration and superficial, especially in the older patients. In these, pain perception is inversely correlated with sleep quality, while, in younger adults, environmental noise is inversely correlated with deep sleep.","PeriodicalId":72279,"journal":{"name":"Archives of clinical and biomedical research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69340922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: This research is based on previous literature concerning mental health conditions in sexual minorities. Taking this background into consideration, here, the role of sexual orientation and sexual orientation-related stress is examined. Aims: The research aims to examine the predictors of depression and suicidality, focusing primarily on the role of sexual identity and sexual orientation-related stress. Methods: A questionnaire was distributed to a sample of 112 participants, from which 64 of them belonged to the LGB community. Results: The results showed that sexual orientation differentiated the median and distribution of depression and suicidality levels, but its effect was insignificant when adjusted with other demographic variables in regressions. Gay-related stress seems to be associated with higher levels of depression. Conclusion: More research is needed to shed light on the risk factors of depression and suicide, especially for LGB participants. Finally, the role of gay-related stress needs to be validated by further studies as well.
{"title":"Is Depression and Suicidality a Matter of Sexual Orientation? An Empirical Investigation in Greece","authors":"S. Kaprinis, Anastasios Charalampakis","doi":"10.26502/acbr.50170296","DOIUrl":"https://doi.org/10.26502/acbr.50170296","url":null,"abstract":"Background: This research is based on previous literature concerning mental health conditions in sexual minorities. Taking this background into consideration, here, the role of sexual orientation and sexual orientation-related stress is examined. Aims: The research aims to examine the predictors of depression and suicidality, focusing primarily on the role of sexual identity and sexual orientation-related stress. Methods: A questionnaire was distributed to a sample of 112 participants, from which 64 of them belonged to the LGB community. Results: The results showed that sexual orientation differentiated the median and distribution of depression and suicidality levels, but its effect was insignificant when adjusted with other demographic variables in regressions. Gay-related stress seems to be associated with higher levels of depression. Conclusion: More research is needed to shed light on the risk factors of depression and suicide, especially for LGB participants. Finally, the role of gay-related stress needs to be validated by further studies as well.","PeriodicalId":72279,"journal":{"name":"Archives of clinical and biomedical research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69341386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01Epub Date: 2022-08-26DOI: 10.26502/acbr.50170279
Vikrant Rai, Gillian Mathews, Devendra K Agrawal
Increased morbidity and mortality after polytrauma due to multiple organ failure (MOF) is a major concern for clinicians. Systemic inflammatory response syndrome (SIRS) and sepsis are the major underlying causes. Damage-associated molecular proteins (DAMPs) released after polytrauma induce an inflammatory immune response to repair the tissue, however, persistent inflammation finally results in immunosuppression and MOF. During immunosuppression, additional exposure of the traumatized tissue to pattern-associated molecular patterns (PAMPs) further adds to the continuum of inflammatory cascade causing sepsis. These two hits worsen the condition of the patient and increase morbidity and mortality. Thus, it is critical to stratify the patient based on trauma severity and inflammatory biomarkers levels and design treatment accordingly for a better clinical outcome. Although some of the molecular mechanisms involved in SIRS and MOF after polytrauma have been reported, there is limited information on the critical factors related to the study of DAMPs and PAMPs, including the timing of sampling (time elapsed after trauma), source of sampling (blood, urine, saliva), proteomics and metabolomics, multiplex plasma assay, comparative interpretation of the results from various sources and diagnostic value, and interpretation on the translational and clinical significance. Additionally, there is limited literature on DAMPs like heat shock proteins, mitochondrial DNA, neutrophil extracellular traps, and their role in SIRS and MOF. Further, it is also important to distinguish between the biomarkers of SIRS and sepsis in a time-bound window to have a better clinical outcome. This critical review focuses on these aspects to provide comprehensive information and thought-provoking discussion to design future investigation and clinical trials.
{"title":"Translational and Clinical Significance of DAMPs, PAMPs, and PRRs in Trauma-induced Inflammation.","authors":"Vikrant Rai, Gillian Mathews, Devendra K Agrawal","doi":"10.26502/acbr.50170279","DOIUrl":"https://doi.org/10.26502/acbr.50170279","url":null,"abstract":"<p><p>Increased morbidity and mortality after polytrauma due to multiple organ failure (MOF) is a major concern for clinicians. Systemic inflammatory response syndrome (SIRS) and sepsis are the major underlying causes. Damage-associated molecular proteins (DAMPs) released after polytrauma induce an inflammatory immune response to repair the tissue, however, persistent inflammation finally results in immunosuppression and MOF. During immunosuppression, additional exposure of the traumatized tissue to pattern-associated molecular patterns (PAMPs) further adds to the continuum of inflammatory cascade causing sepsis. These two hits worsen the condition of the patient and increase morbidity and mortality. Thus, it is critical to stratify the patient based on trauma severity and inflammatory biomarkers levels and design treatment accordingly for a better clinical outcome. Although some of the molecular mechanisms involved in SIRS and MOF after polytrauma have been reported, there is limited information on the critical factors related to the study of DAMPs and PAMPs, including the timing of sampling (time elapsed after trauma), source of sampling (blood, urine, saliva), proteomics and metabolomics, multiplex plasma assay, comparative interpretation of the results from various sources and diagnostic value, and interpretation on the translational and clinical significance. Additionally, there is limited literature on DAMPs like heat shock proteins, mitochondrial DNA, neutrophil extracellular traps, and their role in SIRS and MOF. Further, it is also important to distinguish between the biomarkers of SIRS and sepsis in a time-bound window to have a better clinical outcome. This critical review focuses on these aspects to provide comprehensive information and thought-provoking discussion to design future investigation and clinical trials.</p>","PeriodicalId":72279,"journal":{"name":"Archives of clinical and biomedical research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9491702/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33477121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
U. Saeed, Zahra Zahid Piracha, Hafsa Ashraf, Saba Tasneem, Sara Rizwan Uppal, Tabinda Islam, Maheen Fatima, A. Abid, Rehan Uppal, R. Uppal
SARS-CoV-2 is an mRNA virus that has plunged the whole world into serious trouble for the last two years. Due to continuous transmission, the virus mutates rapidly and new strains emerged which made vaccines less effective. The study aims to describe the impact of major vaccines on different variants of COVID-19. The successful launch of the COVID-19 vaccine raised hope for the extinction of pandemics and return to pre-quarantine life around the globe. Clinical trials revealed all major vaccines provide a short-term satisfactory level of protection against the disease but none of the vaccines is ensuring 100% safety against all variants. Efficacy drop of several vaccines has also been observed against the B.1.1.7, B.1.617, B.1.351 P.1 variants of concern. Phase 3 and phase 4 clinical trials need to be conducted on major vaccines. Chinese vaccines are expected to be most effective against the delta strain yet having no satisfactory results against SOIY.V2, B.1.1.7, and P.1 Arch Clin Biomed Res 2022; 6 (1): 209-216 DOI: 10.26502/acbr.50170236 Archives of Clinical and Biomedical Research Vol. 6 No. 1 – February 2022. [ISSN 2572-9292]. 210 strains. While the western world has a hawk-eye on mRNA vaccines (BNT162b2 and mRNA-1273) having the highest efficacy rate (around 90-95%). Sputnik V vaccine is recently approved for use in more than 66 countries but its effectiveness against all variants of concern (VOC) is not guaranteed. The analysis revealed that overall vaccination is capable to provide 72% efficacy in terms of protection against deaths. None of the vaccines proved to be 100 % effective against all strains of COVID-19 but developed antibodies to fight better and increased chances of survival.
{"title":"Effectivity Analysis of COVID-19 Vaccines Against Emerging Variants of SARS-CoV-2","authors":"U. Saeed, Zahra Zahid Piracha, Hafsa Ashraf, Saba Tasneem, Sara Rizwan Uppal, Tabinda Islam, Maheen Fatima, A. Abid, Rehan Uppal, R. Uppal","doi":"10.26502/acbr.50170236","DOIUrl":"https://doi.org/10.26502/acbr.50170236","url":null,"abstract":"SARS-CoV-2 is an mRNA virus that has plunged the whole world into serious trouble for the last two years. Due to continuous transmission, the virus mutates rapidly and new strains emerged which made vaccines less effective. The study aims to describe the impact of major vaccines on different variants of COVID-19. The successful launch of the COVID-19 vaccine raised hope for the extinction of pandemics and return to pre-quarantine life around the globe. Clinical trials revealed all major vaccines provide a short-term satisfactory level of protection against the disease but none of the vaccines is ensuring 100% safety against all variants. Efficacy drop of several vaccines has also been observed against the B.1.1.7, B.1.617, B.1.351 P.1 variants of concern. Phase 3 and phase 4 clinical trials need to be conducted on major vaccines. Chinese vaccines are expected to be most effective against the delta strain yet having no satisfactory results against SOIY.V2, B.1.1.7, and P.1 Arch Clin Biomed Res 2022; 6 (1): 209-216 DOI: 10.26502/acbr.50170236 Archives of Clinical and Biomedical Research Vol. 6 No. 1 – February 2022. [ISSN 2572-9292]. 210 strains. While the western world has a hawk-eye on mRNA vaccines (BNT162b2 and mRNA-1273) having the highest efficacy rate (around 90-95%). Sputnik V vaccine is recently approved for use in more than 66 countries but its effectiveness against all variants of concern (VOC) is not guaranteed. The analysis revealed that overall vaccination is capable to provide 72% efficacy in terms of protection against deaths. None of the vaccines proved to be 100 % effective against all strains of COVID-19 but developed antibodies to fight better and increased chances of survival.","PeriodicalId":72279,"journal":{"name":"Archives of clinical and biomedical research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69340261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：