Xie Zhimin, Dai Xiangnong, Pan Qiaolin, Liao QingQing, Ye Xingdong
{"title":"Tacrolimus Reverses the Pemphigus Vulgaris Serum-Enhanced Expression of Desmoglein in HaCaT Cells","authors":"Xie Zhimin, Dai Xiangnong, Pan Qiaolin, Liao QingQing, Ye Xingdong","doi":"10.26502/acbr.50170301","DOIUrl":"https://doi.org/10.26502/acbr.50170301","url":null,"abstract":"","PeriodicalId":72279,"journal":{"name":"Archives of clinical and biomedical research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69341507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Marie Suehiro, S. Okubo, Kensuke Nakajima, K. Kanda, M. Hayakawa, S. Oiso, T. Kabashima, Hideaki Fujita, Yukio Ando, T. Muro
development and activity of the immune system, accounting for differences in gender-related immune responses. 13 The ratio of naive B cells before vaccination and the ratio of activated CD8-positive T cells after vaccination are detected as immunological features that positively correlate with the increase in antibody titre after vaccination. 14 The results of this study showed that female participants had a higher incidence of adverse events.
{"title":"Adverse Events Following COVID-19 Vaccination in Young Japanese People: A Case-Control Study of the Risk of Systemic Adverse Events by A Questionnaire Survey","authors":"Marie Suehiro, S. Okubo, Kensuke Nakajima, K. Kanda, M. Hayakawa, S. Oiso, T. Kabashima, Hideaki Fujita, Yukio Ando, T. Muro","doi":"10.26502/acbr.50170222","DOIUrl":"https://doi.org/10.26502/acbr.50170222","url":null,"abstract":"development and activity of the immune system, accounting for differences in gender-related immune responses. 13 The ratio of naive B cells before vaccination and the ratio of activated CD8-positive T cells after vaccination are detected as immunological features that positively correlate with the increase in antibody titre after vaccination. 14 The results of this study showed that female participants had a higher incidence of adverse events.","PeriodicalId":72279,"journal":{"name":"Archives of clinical and biomedical research","volume":"52 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69339914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comprehensive Comparison of Diagnostic Accuracy of Ultrasound and Mammography in Young Women with Radiographically Dense Breasts","authors":"Jitendra Parmar, Sumita Choudhary, Anagha Zope, Tapan Patel, Nishith K. Chaudhari, Sandip Shah, Maulik Vora, Harsh Vyas","doi":"10.26502/acbr.50170246","DOIUrl":"https://doi.org/10.26502/acbr.50170246","url":null,"abstract":"","PeriodicalId":72279,"journal":{"name":"Archives of clinical and biomedical research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69340587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
COVID-19 is a recent globally-manifested phenomenon that compels healthcare workers to face and rapidly adapt to forceful changes. While much of the research has a general focus on all healthcare professions,this work has the specific focus on radiographers because they play a critical role in monitoring the spread of COVID-19. A Pandemic Experiences and Perceptions Survey (PEPS) was used to report on radiographers’ experiences. A cross-sectional questionnaire survey was distributed to radiographers between May and June 2020. A number of 102 (29.4%) completed the survey (48 [47.1%] males and 54 [52.9%] females). With respect to the five PEPS tools, the means (± SD) of each tool were as follows: disruption, 2.487 (±0.94); resources, 2.576 (±0.914); risk perception, 2.946 (±1.57); impact on work-life areas, 3.81 (±0.711); and leadership, 3.795 (±0.807). Eighty percent of radiographers were in agreement that COVID-19 affected their work distribution and 74.5% did not consider their protective equipment, staff availability, and support staff competence to be adequate. Sixtytwo percent of the participants reported fear of the virus. This study allows for front-line radiographers to quickly express concerns and provides insight into the issues that must be addressed during the current and future outbreaks.
{"title":"Measurement of Radiographers’ Pandemic Experiences and Perceptions During COVID-19","authors":"Muna Almulla","doi":"10.26502/acbr.50170247","DOIUrl":"https://doi.org/10.26502/acbr.50170247","url":null,"abstract":"COVID-19 is a recent globally-manifested phenomenon that compels healthcare workers to face and rapidly adapt to forceful changes. While much of the research has a general focus on all healthcare professions,this work has the specific focus on radiographers because they play a critical role in monitoring the spread of COVID-19. A Pandemic Experiences and Perceptions Survey (PEPS) was used to report on radiographers’ experiences. A cross-sectional questionnaire survey was distributed to radiographers between May and June 2020. A number of 102 (29.4%) completed the survey (48 [47.1%] males and 54 [52.9%] females). With respect to the five PEPS tools, the means (± SD) of each tool were as follows: disruption, 2.487 (±0.94); resources, 2.576 (±0.914); risk perception, 2.946 (±1.57); impact on work-life areas, 3.81 (±0.711); and leadership, 3.795 (±0.807). Eighty percent of radiographers were in agreement that COVID-19 affected their work distribution and 74.5% did not consider their protective equipment, staff availability, and support staff competence to be adequate. Sixtytwo percent of the participants reported fear of the virus. This study allows for front-line radiographers to quickly express concerns and provides insight into the issues that must be addressed during the current and future outbreaks.","PeriodicalId":72279,"journal":{"name":"Archives of clinical and biomedical research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69340591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N. Dia, M. Diagne, G. Fall, Mamadou Malado Jallow, Amary Fall, Mamadou Alioune Barry, A. Diallo, O. Faye, Marie Henriette Dior Dione, Ndeye Sakha Bop, Safietou Sankhe, Martin Faye, Idrissa Dieng, M. Diop, C. Loucoubar, C. Peyreffite, Amadou Alpha Sall, O. Faye
{"title":"COVID-19 and Children in Senegal: Epidemiological and Virological Insights","authors":"N. Dia, M. Diagne, G. Fall, Mamadou Malado Jallow, Amary Fall, Mamadou Alioune Barry, A. Diallo, O. Faye, Marie Henriette Dior Dione, Ndeye Sakha Bop, Safietou Sankhe, Martin Faye, Idrissa Dieng, M. Diop, C. Loucoubar, C. Peyreffite, Amadou Alpha Sall, O. Faye","doi":"10.26502/acbr.50170250","DOIUrl":"https://doi.org/10.26502/acbr.50170250","url":null,"abstract":"","PeriodicalId":72279,"journal":{"name":"Archives of clinical and biomedical research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69340601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.1101/2021.03.02.21250607
J. Xi, Wai Kin (Victor) Chan
The safety of students worldwide remains a key issue during COVID-19. The reopening of universities in high risk countries during Fall 2020 resulted in numerous outbreaks. While regular screening and testing on campus can prevent the transmission of SARS-CoV-2, they are extremely challenging to implement due to various reasons such as cost and logistics. However, for low risk countries with minimal to no community spread, our study suggests that universities can fully reopen without testing, if students self-quarantine for 14 days on arrival and adopt proper nonpharmaceutical interventions (NPIs). This alternative strategy might save institutions millions of dollars. We adopt agent-based simulation to model virus transmission on campus and test the effectiveness of several NPIs when school reopens. Assuming one initially infected student, results indicate that transmission between roommates causes the most infections with visitors, ground floors, and elevators, being the next main contributors. Limiting density and/or population are not impactful at flattening the curve. However, adopting masks, minimizing movement, and increasing the frequency of cleaning can effectively minimize infection and prevent outbreak, allowing for classes and activities to resume as normal.
{"title":"Reopening Universities without Testing During COVID-19: Evaluating a Possible Alternative Strategy in Low Risk Countries","authors":"J. Xi, Wai Kin (Victor) Chan","doi":"10.1101/2021.03.02.21250607","DOIUrl":"https://doi.org/10.1101/2021.03.02.21250607","url":null,"abstract":"The safety of students worldwide remains a key issue during COVID-19. The reopening of universities in high risk countries during Fall 2020 resulted in numerous outbreaks. While regular screening and testing on campus can prevent the transmission of SARS-CoV-2, they are extremely challenging to implement due to various reasons such as cost and logistics. However, for low risk countries with minimal to no community spread, our study suggests that universities can fully reopen without testing, if students self-quarantine for 14 days on arrival and adopt proper nonpharmaceutical interventions (NPIs). This alternative strategy might save institutions millions of dollars. We adopt agent-based simulation to model virus transmission on campus and test the effectiveness of several NPIs when school reopens. Assuming one initially infected student, results indicate that transmission between roommates causes the most infections with visitors, ground floors, and elevators, being the next main contributors. Limiting density and/or population are not impactful at flattening the curve. However, adopting masks, minimizing movement, and increasing the frequency of cleaning can effectively minimize infection and prevent outbreak, allowing for classes and activities to resume as normal.","PeriodicalId":72279,"journal":{"name":"Archives of clinical and biomedical research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"62323208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Marghoob, U. Saeed, Zahra Zahid Piracha, Haiqa Shafiq, Noor e Fatima, Nimra Sarfraz, Noor Farooq, R. Uppal
With COVID 19 becoming a most important worldwide cause of concern, it is significant to comprehend the various manifestations of the disease to fully accomplish it. No country is untouched by the plague of this new disease which was first reported from Wuhan, China in December 2019. It is an infectious disease caused by novel coronavirus i-e; SARS-CoV-2. The rapid spread of this disease as well as the illness and mortality associated with this disease has led to unprecedented research into the various aspects of this disease. While respiratory catalogs are the most predominant feature of this disease, with time it has been initiate that the virus can include almost any organ in the human body. Covid-19 has overcome human wellbeing worldwide while also vigorously affecting the worldwide economy. SARS-CoV-2 has influenced more than 220 nations and domains, with roughly 4176,185 deaths so far across the globe. Recently, Mucormycosis made serious disarray in India during the second wave (among April and June 2021) of the tragical COVID-19 upsurge by its startling and severe overflow with up to half the death rate. Mucormycosis is a deadly parasitic infection brought about by a kind of uncommon yet deft contagious microorganism called mucormycetes. While the specific reason for its sharp ascent out of nowhere and explicitly during the second wave stays disputable, it has been noticed that individuals who are diabetic and have recuperated from COVID-19 Arch Clin Biomed Res 2021; 6 (1): 41-49 DOI: 10.26502/acbr.50170224 Archives of Clinical and Biomedical Research Vol. 6 No. 1 – February 2022. [ISSN 2572-9292]. 42 disease are more inclined to Mucormycosis. In this review, we will briefly discuss the relation between COVID-19 and Mucormycosis.
{"title":"SARS-CoV-2 Infection and Incidence of Mucormycosis","authors":"M. Marghoob, U. Saeed, Zahra Zahid Piracha, Haiqa Shafiq, Noor e Fatima, Nimra Sarfraz, Noor Farooq, R. Uppal","doi":"10.26502/acbr.50170224","DOIUrl":"https://doi.org/10.26502/acbr.50170224","url":null,"abstract":"With COVID 19 becoming a most important worldwide cause of concern, it is significant to comprehend the various manifestations of the disease to fully accomplish it. No country is untouched by the plague of this new disease which was first reported from Wuhan, China in December 2019. It is an infectious disease caused by novel coronavirus i-e; SARS-CoV-2. The rapid spread of this disease as well as the illness and mortality associated with this disease has led to unprecedented research into the various aspects of this disease. While respiratory catalogs are the most predominant feature of this disease, with time it has been initiate that the virus can include almost any organ in the human body. Covid-19 has overcome human wellbeing worldwide while also vigorously affecting the worldwide economy. SARS-CoV-2 has influenced more than 220 nations and domains, with roughly 4176,185 deaths so far across the globe. Recently, Mucormycosis made serious disarray in India during the second wave (among April and June 2021) of the tragical COVID-19 upsurge by its startling and severe overflow with up to half the death rate. Mucormycosis is a deadly parasitic infection brought about by a kind of uncommon yet deft contagious microorganism called mucormycetes. While the specific reason for its sharp ascent out of nowhere and explicitly during the second wave stays disputable, it has been noticed that individuals who are diabetic and have recuperated from COVID-19 Arch Clin Biomed Res 2021; 6 (1): 41-49 DOI: 10.26502/acbr.50170224 Archives of Clinical and Biomedical Research Vol. 6 No. 1 – February 2022. [ISSN 2572-9292]. 42 disease are more inclined to Mucormycosis. In this review, we will briefly discuss the relation between COVID-19 and Mucormycosis.","PeriodicalId":72279,"journal":{"name":"Archives of clinical and biomedical research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69339927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rodolfo Augusto Alves Pedrão, R. Riella, S. Valderramas
Objective: To assess the characteristics and quality of sleep in critically ill older and younger adults and verify the differences between these groups. Check for associations between sleep and the perception of pain, noise, temperature, environmental luminance and the use of opiods and benzodiazepines. Method: Cross-sectional observational study, which evaluated lucid critically ill individuals, older and younger adults, with diseases of low or moderate severity. Sleep characteristics were measured using the Bispectral Index; sleep quality was measured using the Richards-Campbell Sleep Questionnaire; pain level was measured by Visual-Analog Scale; we recorded the ambient sound pressure, luminance and temperature, as well as the administered doses of opiods and benzodiazepines. Results: The medians of total sleep time, deep sleep time, pain intensity, luminance, ambient temperature, continuous sound pressure equivalent and perceived sleep quality were 237 minutes, 0 minutes, 1/10 point, 13.26 Lux, 22.4ºC, 57.27 decibels and 61/100 points, respectively. No older participant achieved deep sleep. In older people, pain and sleep quality are inversely correlated (ρ = -.48; p <.05); in younger adults, volume and time of deep sleep were inversely correlated with environmental noise (ρ = -.45; p<.05 and ρ = -.44; p<.05, respectively). Conclusion: The sleep of adult patients with low and medium severity illnesses admitted to the ICU is of short duration and superficial, especially in the older patients. In these, pain perception is inversely correlated with sleep quality, while, in younger adults, environmental noise is inversely correlated with deep sleep.
{"title":"The Sleep in the Critically Ill Aged Patients","authors":"Rodolfo Augusto Alves Pedrão, R. Riella, S. Valderramas","doi":"10.26502/acbr.50170274","DOIUrl":"https://doi.org/10.26502/acbr.50170274","url":null,"abstract":"Objective: To assess the characteristics and quality of sleep in critically ill older and younger adults and verify the differences between these groups. Check for associations between sleep and the perception of pain, noise, temperature, environmental luminance and the use of opiods and benzodiazepines. Method: Cross-sectional observational study, which evaluated lucid critically ill individuals, older and younger adults, with diseases of low or moderate severity. Sleep characteristics were measured using the Bispectral Index; sleep quality was measured using the Richards-Campbell Sleep Questionnaire; pain level was measured by Visual-Analog Scale; we recorded the ambient sound pressure, luminance and temperature, as well as the administered doses of opiods and benzodiazepines. Results: The medians of total sleep time, deep sleep time, pain intensity, luminance, ambient temperature, continuous sound pressure equivalent and perceived sleep quality were 237 minutes, 0 minutes, 1/10 point, 13.26 Lux, 22.4ºC, 57.27 decibels and 61/100 points, respectively. No older participant achieved deep sleep. In older people, pain and sleep quality are inversely correlated (ρ = -.48; p <.05); in younger adults, volume and time of deep sleep were inversely correlated with environmental noise (ρ = -.45; p<.05 and ρ = -.44; p<.05, respectively). Conclusion: The sleep of adult patients with low and medium severity illnesses admitted to the ICU is of short duration and superficial, especially in the older patients. In these, pain perception is inversely correlated with sleep quality, while, in younger adults, environmental noise is inversely correlated with deep sleep.","PeriodicalId":72279,"journal":{"name":"Archives of clinical and biomedical research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69340922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: This research is based on previous literature concerning mental health conditions in sexual minorities. Taking this background into consideration, here, the role of sexual orientation and sexual orientation-related stress is examined. Aims: The research aims to examine the predictors of depression and suicidality, focusing primarily on the role of sexual identity and sexual orientation-related stress. Methods: A questionnaire was distributed to a sample of 112 participants, from which 64 of them belonged to the LGB community. Results: The results showed that sexual orientation differentiated the median and distribution of depression and suicidality levels, but its effect was insignificant when adjusted with other demographic variables in regressions. Gay-related stress seems to be associated with higher levels of depression. Conclusion: More research is needed to shed light on the risk factors of depression and suicide, especially for LGB participants. Finally, the role of gay-related stress needs to be validated by further studies as well.
{"title":"Is Depression and Suicidality a Matter of Sexual Orientation? An Empirical Investigation in Greece","authors":"S. Kaprinis, Anastasios Charalampakis","doi":"10.26502/acbr.50170296","DOIUrl":"https://doi.org/10.26502/acbr.50170296","url":null,"abstract":"Background: This research is based on previous literature concerning mental health conditions in sexual minorities. Taking this background into consideration, here, the role of sexual orientation and sexual orientation-related stress is examined. Aims: The research aims to examine the predictors of depression and suicidality, focusing primarily on the role of sexual identity and sexual orientation-related stress. Methods: A questionnaire was distributed to a sample of 112 participants, from which 64 of them belonged to the LGB community. Results: The results showed that sexual orientation differentiated the median and distribution of depression and suicidality levels, but its effect was insignificant when adjusted with other demographic variables in regressions. Gay-related stress seems to be associated with higher levels of depression. Conclusion: More research is needed to shed light on the risk factors of depression and suicide, especially for LGB participants. Finally, the role of gay-related stress needs to be validated by further studies as well.","PeriodicalId":72279,"journal":{"name":"Archives of clinical and biomedical research","volume":"44 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69341386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
V. Papaioannou, K. Budohoski, Michał M. Placek, Z. Czosnyka, P. Smielewski, M. Czosnyka
Background: In patients suffering from Subarachnoid Hemorrhage (SAH), Delayed Cerebral Ischemia (DCI) is partly associated with Vasospasm (VS) and impaired cerebral autoregulation. We investigated the pattern of changes of different Transcranial Doppler (TCD)-derived indices of cerebrovascular dynamics during VS, in patients dichotomized by the presence of DCI. Methods: A retrospective analysis was performed using recordings from 32 SAH patients, diagnosed with VS through bilateral TCD measurements. Patients were divided in 2 groups, depending on development of DCI. Cerebral autoregulation was estimated using the moving correlation coefficient Mxa, calculated from spontaneous fluctuations of Cerebral Blood Flow Velocity (CBFV) and Arterial Blood Pressure (ABP). We also measured cerebral arterial time constant (tau) as the product of resistance (Ra) and Compliance (Ca) and Critical Closing Pressure (CrCP), using two different methods of assessment (CrCPAaslid and CrCPVarsos). Results: In the whole population (N=32), VS caused shortening of tau (ipsilateral to spasm: 0.17 ± 0.08 vs before: 0.25 ± 0.17 sec, p = 0.04), decrease in CrCPAaslid (ipsilateral to spasm: 9.69 ± 23.28 vs before: 27.23 ± 23.31 mmHg, p = 0.01) and interhemispheric asymmetry with lower values on ipsilateral side (p < 0.01). Ipsilateral CrCPAaslid during VS was negatively correlated with Mxa (r =-0.43, p=0.01), whereas CrCPVarsos exhibited positive correlation with tau (r=0.74, p < 0.001). In patients with DCI (N=19), VS caused increase in Mxa (ipsilateral to spasm: 0.36 ± 0.18 vs before: 0.26 ± 0.23, p = 0.04), decrease in CrCPAaslid (ipsilateral to spasm: 6.61 ± 24.5 vs before: 17.24 ± 19.4 mmHg, p = 0.04) and lower values on ipsilateral side (p < 0.01). Arch Clin Biomed Res 2022; 6 (1): 119-133 DOI: 10.26502/acbr.50170230 Archives of Clinical and Biomedical Research Vol. 6 No. 1 – February 2022. [ISSN 2572-9292]. 120 Conclusions: During VS, tau and CrCP were reduced in both temporal and spatial assessments, whereas DCI was associated with loss of autoregulation and vasoparalysis.
背景:在蛛网膜下腔出血(SAH)患者中，延迟性脑缺血(DCI)与血管痉挛(VS)和大脑自动调节功能受损部分相关。我们研究了经颅多普勒(TCD)衍生的不同脑血管动力学指标在VS期间的变化模式，在DCI存在的患者中。方法:回顾性分析32例SAH患者的记录，通过双侧TCD测量诊断为VS。根据DCI的发展情况将患者分为两组。根据脑血流速度(CBFV)和动脉血压(ABP)的自发波动计算的运动相关系数Mxa估计脑自动调节。我们还使用两种不同的评估方法(CrCPAaslid和CrCPVarsos)测量了脑动脉时间常数(tau)作为阻力(Ra)和顺应性(Ca)和临界闭合压(CrCP)的乘积。结果:在所有人群中(N=32)， VS引起tau缩短(同侧痉挛:0.17±0.08 VS前:0.25±0.17 sec, p = 0.04)， CrCPAaslid降低(同侧痉挛:9.69±23.28 VS前:27.23±23.31 mmHg, p = 0.01)和半球间不对称(同侧较低)(p < 0.01)。VS时同侧crcppaaslid与Mxa呈负相关(r= -0.43, p=0.01)，而CrCPVarsos与tau呈正相关(r=0.74, p < 0.001)。在DCI患者(N=19)中，VS导致Mxa升高(同侧痉挛:0.36±0.18 VS前:0.26±0.23,p = 0.04)， CrCPAaslid降低(同侧痉挛:6.61±24.5 VS前:17.24±19.4 mmHg, p = 0.04)，同侧降低(p < 0.01)。Arch clinn Biomed Res 2022;6 (1): 119-133 DOI: 10.26502/acbr.50170230临床和生物医学研究档案第6卷第1期- 2022年2月。(ISSN 2572 - 9292)。120结论:在VS期间，tau和CrCP在时间和空间评估中都降低，而DCI与自我调节丧失和血管麻痹有关。
{"title":"Relation between Mean Velocity Index, Time Constant and Critical Closing Pressure in Patients with Subarachnoid Hemorrhage","authors":"V. Papaioannou, K. Budohoski, Michał M. Placek, Z. Czosnyka, P. Smielewski, M. Czosnyka","doi":"10.26502/acbr.50170230","DOIUrl":"https://doi.org/10.26502/acbr.50170230","url":null,"abstract":"Background: In patients suffering from Subarachnoid Hemorrhage (SAH), Delayed Cerebral Ischemia (DCI) is partly associated with Vasospasm (VS) and impaired cerebral autoregulation. We investigated the pattern of changes of different Transcranial Doppler (TCD)-derived indices of cerebrovascular dynamics during VS, in patients dichotomized by the presence of DCI. Methods: A retrospective analysis was performed using recordings from 32 SAH patients, diagnosed with VS through bilateral TCD measurements. Patients were divided in 2 groups, depending on development of DCI. Cerebral autoregulation was estimated using the moving correlation coefficient Mxa, calculated from spontaneous fluctuations of Cerebral Blood Flow Velocity (CBFV) and Arterial Blood Pressure (ABP). We also measured cerebral arterial time constant (tau) as the product of resistance (Ra) and Compliance (Ca) and Critical Closing Pressure (CrCP), using two different methods of assessment (CrCPAaslid and CrCPVarsos). Results: In the whole population (N=32), VS caused shortening of tau (ipsilateral to spasm: 0.17 ± 0.08 vs before: 0.25 ± 0.17 sec, p = 0.04), decrease in CrCPAaslid (ipsilateral to spasm: 9.69 ± 23.28 vs before: 27.23 ± 23.31 mmHg, p = 0.01) and interhemispheric asymmetry with lower values on ipsilateral side (p < 0.01). Ipsilateral CrCPAaslid during VS was negatively correlated with Mxa (r =-0.43, p=0.01), whereas CrCPVarsos exhibited positive correlation with tau (r=0.74, p < 0.001). In patients with DCI (N=19), VS caused increase in Mxa (ipsilateral to spasm: 0.36 ± 0.18 vs before: 0.26 ± 0.23, p = 0.04), decrease in CrCPAaslid (ipsilateral to spasm: 6.61 ± 24.5 vs before: 17.24 ± 19.4 mmHg, p = 0.04) and lower values on ipsilateral side (p < 0.01). Arch Clin Biomed Res 2022; 6 (1): 119-133 DOI: 10.26502/acbr.50170230 Archives of Clinical and Biomedical Research Vol. 6 No. 1 – February 2022. [ISSN 2572-9292]. 120 Conclusions: During VS, tau and CrCP were reduced in both temporal and spatial assessments, whereas DCI was associated with loss of autoregulation and vasoparalysis.","PeriodicalId":72279,"journal":{"name":"Archives of clinical and biomedical research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69340110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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