Komi Victor-Mari Setondji, K. A. Traore, J. Ouoba, E. Taale, B. Ouoba, Bissah Kokou Nyakou, P. Roques, Simplice Damintoti Karou, N. Barro
Background: Hepatitis E virus (HEV) antibodies prevalence is reported globally worldwide. However, there is still some countries where data are not well reported or even studied as in Togo. The aim of this study was to evaluate the seroprevalence of HEV among human populations and analyze demographic variables related to the infection in the city of Sokodé, in central area of Togo. Results: A total of 289 individuals including 195 blood donors (24 women and 171 men), and 94 pregnant women were recruited from May to October 2020 and socio-economic status were assessed. All obtained sera were tested for the presence of anti-HEV antibodies with the immunochromatography test (MP Diagnostics ASSURE IgM Rapid test) and the MP Diagnostics HEV-IgM and HEV-IgG ELISA. The association between anti-HEV status and potential risk factors was assessed. Total HEV antibodies were in 5.6% (95% CI: 3.8 - 7.3%) of all samples. HEV IgM antibodies were detected in 11.7% (95% CI: 9.8-13.5%) of the samples, of which 29 (14.8%) were from the blood donors group and 5 (5.3%) from pregnant women group. Gender, water storage container, type of latrine used and washing hands after toilet were associated to anti-HEV IgM seropositivity in population. (p ≤ 0.05). Conclusion: These �ndings from asymptomatic population suggest a probable HEV circulation at signi�cant levels. These data are the �rst step to understand the epidemiology of the HEV infection in Togo that deserved to be extended both in timing and Togo’s region.
{"title":"Seroprevalence of Hepatitis E Virus (HEV) Antibodies in Human Populations of Sokodé, Togo","authors":"Komi Victor-Mari Setondji, K. A. Traore, J. Ouoba, E. Taale, B. Ouoba, Bissah Kokou Nyakou, P. Roques, Simplice Damintoti Karou, N. Barro","doi":"10.26502/acbr.5070316","DOIUrl":"https://doi.org/10.26502/acbr.5070316","url":null,"abstract":"Background: Hepatitis E virus (HEV) antibodies prevalence is reported globally worldwide. However, there is still some countries where data are not well reported or even studied as in Togo. The aim of this study was to evaluate the seroprevalence of HEV among human populations and analyze demographic variables related to the infection in the city of Sokodé, in central area of Togo. Results: A total of 289 individuals including 195 blood donors (24 women and 171 men), and 94 pregnant women were recruited from May to October 2020 and socio-economic status were assessed. All obtained sera were tested for the presence of anti-HEV antibodies with the immunochromatography test (MP Diagnostics ASSURE IgM Rapid test) and the MP Diagnostics HEV-IgM and HEV-IgG ELISA. The association between anti-HEV status and potential risk factors was assessed. Total HEV antibodies were in 5.6% (95% CI: 3.8 - 7.3%) of all samples. HEV IgM antibodies were detected in 11.7% (95% CI: 9.8-13.5%) of the samples, of which 29 (14.8%) were from the blood donors group and 5 (5.3%) from pregnant women group. Gender, water storage container, type of latrine used and washing hands after toilet were associated to anti-HEV IgM seropositivity in population. (p ≤ 0.05). Conclusion: These �ndings from asymptomatic population suggest a probable HEV circulation at signi�cant levels. These data are the �rst step to understand the epidemiology of the HEV infection in Togo that deserved to be extended both in timing and Togo’s region.","PeriodicalId":72279,"journal":{"name":"Archives of clinical and biomedical research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69342145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nathan L Tintle, J. Westra, K. Van De Griend, Virginia Beard, Benjamin N Turner, Natalie L H Huisman, Nicholas Dawson, L. Droscha, Clay Ihle, Matthew Moore, Marilyn G Orellana, L. L. Schutter, Lydia Snyder, Devin White, Makayla S. Wilson, Grace K. Goszkowicz, Brent P Krueger, Aaron A Best
37 Background There is increasing evidence of the efficacy of point-of-use water filters on diarrhea 38 prevalence in numerous global settings, in both observational studies and randomized experiments. Most 39 studies, however, are focused on rural locations. Methods We use self-report household surveys to 40 monitor a set of approximately 10,000 households receiving point-of-use water filters and WASH training 41 in Kibera, Kenya. Twenty-five drinking water sources throughout the 7 neighborhoods were also selected 42 for testing of E. coli, total coliform, bacterial 16S rRNA community sequencing and metals. Albendazole 43 was provided to all households at distribution as part of the standard filter distribution protocol, with a 44
{"title":"Improvements in Diarrheal Disease Prevalence with Point-of-use Water Filter Implementation in the Informal Settlement of Kibera, Kenya","authors":"Nathan L Tintle, J. Westra, K. Van De Griend, Virginia Beard, Benjamin N Turner, Natalie L H Huisman, Nicholas Dawson, L. Droscha, Clay Ihle, Matthew Moore, Marilyn G Orellana, L. L. Schutter, Lydia Snyder, Devin White, Makayla S. Wilson, Grace K. Goszkowicz, Brent P Krueger, Aaron A Best","doi":"10.26502/acbr.50170358","DOIUrl":"https://doi.org/10.26502/acbr.50170358","url":null,"abstract":"37 Background There is increasing evidence of the efficacy of point-of-use water filters on diarrhea 38 prevalence in numerous global settings, in both observational studies and randomized experiments. Most 39 studies, however, are focused on rural locations. Methods We use self-report household surveys to 40 monitor a set of approximately 10,000 households receiving point-of-use water filters and WASH training 41 in Kibera, Kenya. Twenty-five drinking water sources throughout the 7 neighborhoods were also selected 42 for testing of E. coli, total coliform, bacterial 16S rRNA community sequencing and metals. Albendazole 43 was provided to all households at distribution as part of the standard filter distribution protocol, with a 44","PeriodicalId":72279,"journal":{"name":"Archives of clinical and biomedical research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69341524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Naqash Mazhar, Usman Hassan Khan, Bakhat Mand, A. Rehman, Maryam Mubeen, Mohammad Hamza Bin Abdul Malik, Syed Anas Hussain
{"title":"Frequency of Risk Factors of Coronary Heart Diseases in Patients with Acute Coronary Syndrome and its Comparison in Male and Female","authors":"Naqash Mazhar, Usman Hassan Khan, Bakhat Mand, A. Rehman, Maryam Mubeen, Mohammad Hamza Bin Abdul Malik, Syed Anas Hussain","doi":"10.26502/acbr.50170330","DOIUrl":"https://doi.org/10.26502/acbr.50170330","url":null,"abstract":"","PeriodicalId":72279,"journal":{"name":"Archives of clinical and biomedical research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69341713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Spermine Phosphate-Bound Cyclooctaoxygen Sodium Epigenetic Shell of Euchromatin DNA Is Destroyed by the Epigenetic Poison Glyphosate","authors":"Andreas J Kesel","doi":"10.26502/acbr.50170331","DOIUrl":"https://doi.org/10.26502/acbr.50170331","url":null,"abstract":"","PeriodicalId":72279,"journal":{"name":"Archives of clinical and biomedical research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69341723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Interactive Knowledge Construction in Medical Problem-Based Learning: A Corpus-Based Study","authors":"Olukayode Matthew Tokode, R. Dennick","doi":"10.26502/acbr.50170339","DOIUrl":"https://doi.org/10.26502/acbr.50170339","url":null,"abstract":"","PeriodicalId":72279,"journal":{"name":"Archives of clinical and biomedical research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69341742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Adam B. Sumlin, A. Houjaij, Oussama M. Darwish, Susan Camacho, A. Groman, Z. Fayazi
{"title":"Financial Toxicity and Strain among Veteran and Civilian Men with Prostate Cancer","authors":"Adam B. Sumlin, A. Houjaij, Oussama M. Darwish, Susan Camacho, A. Groman, Z. Fayazi","doi":"10.26502/acbr.50170343","DOIUrl":"https://doi.org/10.26502/acbr.50170343","url":null,"abstract":"","PeriodicalId":72279,"journal":{"name":"Archives of clinical and biomedical research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69341776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
P. Prakash, Rahul S. Rajan, A. Deepti, A. Vengellur, Unnikrishnan Sivan, Baby Chakrapani PS
{"title":"Efficient Generation of Tyrosine Hydroxylase-Expressing Dopamine- Producing Neurons from Rat Peripheral Blood Progenitors Using a Combination of Growth Factors and Biomimetic Matrix","authors":"P. Prakash, Rahul S. Rajan, A. Deepti, A. Vengellur, Unnikrishnan Sivan, Baby Chakrapani PS","doi":"10.26502/acbr.50170332","DOIUrl":"https://doi.org/10.26502/acbr.50170332","url":null,"abstract":"","PeriodicalId":72279,"journal":{"name":"Archives of clinical and biomedical research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69341732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Amirouche, Hugo Felix, R. Serreau, P. Denormandie, Julia Fernández, Sarah Coscas, L. Blecha, A. Benyamina
{"title":"Addiction among Health Care Professionals? What is the Current State of Nurses, Caregivers and Paramedics in 2022? A Review","authors":"A. Amirouche, Hugo Felix, R. Serreau, P. Denormandie, Julia Fernández, Sarah Coscas, L. Blecha, A. Benyamina","doi":"10.26502/acbr.50170340","DOIUrl":"https://doi.org/10.26502/acbr.50170340","url":null,"abstract":"","PeriodicalId":72279,"journal":{"name":"Archives of clinical and biomedical research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69341751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.22491/2357-9730.128680
Rodrigo Borges Noguera, Tauana Bandeira Gonçalves, Rafael Bueno Orcy, Luiz Alberto Forgiarini Junior
A fisioterapia na unidade de terapia intensiva (UTI) apresenta como objetivo utilizar estratégias de mobilização precoce a fim de reduzir o impacto da fraqueza muscular adquirida na UTI. Logo, este estudo apresenta como objetivo avaliar a efetividade de um plano de metas fisioterapêuticas para pacientes internados em uma Unidade de Terapia Intensiva.
{"title":"Efetividade de um plano de metas fisioterapêuticas em pacientes internados em uma unidade de terapia intensiva: uma análise retrospectiva vs. prospectiva","authors":"Rodrigo Borges Noguera, Tauana Bandeira Gonçalves, Rafael Bueno Orcy, Luiz Alberto Forgiarini Junior","doi":"10.22491/2357-9730.128680","DOIUrl":"https://doi.org/10.22491/2357-9730.128680","url":null,"abstract":"A fisioterapia na unidade de terapia intensiva (UTI) apresenta como objetivo utilizar estratégias de mobilização precoce a fim de reduzir o impacto da fraqueza muscular adquirida na UTI. Logo, este estudo apresenta como objetivo avaliar a efetividade de um plano de metas fisioterapêuticas para pacientes internados em uma Unidade de Terapia Intensiva.","PeriodicalId":72279,"journal":{"name":"Archives of clinical and biomedical research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135843666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aim: To compare the mortality in emergency laparotomy cases between those with COVID-19 infection to those without the infection and to identify predicting factors that would help in optimum management for the same. Method: A prospective observational study was conducted in a tertiary care centre in Mumbai. Patients underwent exploratory laparotomy of which 20 were COVID-19 positive (Group A) while 20 were COVID-19 negative (Group B). Patient’s details with blood investigations, radiological investigations, preoperative and postoperative stay were taken into consideration. All these parameters were studied and compared in detail. Result: 40 cases that underwent emergency laparotomy for various causes were compared. Pulmonary complications were seen postoperatively in 45% patients of Group A and 15% patients of Group B. Mortality was seen in 40% cases of Group A of which 87.5% cases were due to postoperative respiratory complications due to COVID-19 infection. Group B had one mortality, due to septic shock. Mortality was significantly higher in Group A(p-value: 0.008). Comorbidities such as hypertension, diabetes mellitus and ischemic heart disease were seen to be associated with a higher incidence of mortality. Mortality was witnessed more in the age group above 40 years. High APACHE-II score and Computed Tomography severity index (CTSI) showed higher mortality. Antivirals did not show any effect on postoperative survival. Conclusion: Emergency operations can be taken up in COVID-19 positive patients with adequate precautions. Postoperative complications are related to comorbidities, age and CTSI. High index of suspicion for pulmonary complications and aggressive postoperative management with steroids gives improved outcomes.
{"title":"Explorations Gone Viral: A Comparative Study of Emergency Laparotomies in COVID-19 Positive vs COVID-19 Negative Patients at A Tertiary Care Hospital during the COVID-19 Pandemic","authors":"Aishwarya Dutt, Ajay Bhandarwar, Girish Bakhshi, Nikhil Dhimole, Harshal Padekar, Snehal Dandge, Kaushal Lahoti, Advaith Chetan, Apoorva Raichur","doi":"10.26502/acbr.50170366","DOIUrl":"https://doi.org/10.26502/acbr.50170366","url":null,"abstract":"Aim: To compare the mortality in emergency laparotomy cases between those with COVID-19 infection to those without the infection and to identify predicting factors that would help in optimum management for the same. Method: A prospective observational study was conducted in a tertiary care centre in Mumbai. Patients underwent exploratory laparotomy of which 20 were COVID-19 positive (Group A) while 20 were COVID-19 negative (Group B). Patient’s details with blood investigations, radiological investigations, preoperative and postoperative stay were taken into consideration. All these parameters were studied and compared in detail. Result: 40 cases that underwent emergency laparotomy for various causes were compared. Pulmonary complications were seen postoperatively in 45% patients of Group A and 15% patients of Group B. Mortality was seen in 40% cases of Group A of which 87.5% cases were due to postoperative respiratory complications due to COVID-19 infection. Group B had one mortality, due to septic shock. Mortality was significantly higher in Group A(p-value: 0.008). Comorbidities such as hypertension, diabetes mellitus and ischemic heart disease were seen to be associated with a higher incidence of mortality. Mortality was witnessed more in the age group above 40 years. High APACHE-II score and Computed Tomography severity index (CTSI) showed higher mortality. Antivirals did not show any effect on postoperative survival. Conclusion: Emergency operations can be taken up in COVID-19 positive patients with adequate precautions. Postoperative complications are related to comorbidities, age and CTSI. High index of suspicion for pulmonary complications and aggressive postoperative management with steroids gives improved outcomes.","PeriodicalId":72279,"journal":{"name":"Archives of clinical and biomedical research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135959497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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