Cerebrovascular diseases of ischemic genesis tend to increase, rejuvenate, are associated with severe clinical course, high rates of disability and mortality. The urgency of the problem of cerebrovascular diseases can rightfully be defined as extraordinary, requiring the concentration of efforts of specialists of different profiles to solve it. Subtotal cerebral ischemia leads to the development of morpho functional disturbances of the cerebral cortex. The introduction of Omega-3 polyunsaturated fatty acids has a corrective effect on the hippocampus in conditions of subtotal ischemia, reducing the number of shadow cells and hyperchromic shrunken neurons, without significantly affecting the size and shape of neurons in the cerebral cortex. Prior administration of L-NAME, the use of Omega-3 did not prevent the effects of the NO synthase inhibitor and associated NO deficiency at this dose and route of administration.
{"title":"Morphological changes in the neurons of the parietal cortex and hippocampus of rats with subtotal cerebral ischemia under conditions of the use of modulators of the L-arginine-NO pathway and against the background of the administration of Omega-3 pol","authors":"Bon E.I,","doi":"10.58489/2836-5828/004","DOIUrl":"https://doi.org/10.58489/2836-5828/004","url":null,"abstract":"Cerebrovascular diseases of ischemic genesis tend to increase, rejuvenate, are associated with severe clinical course, high rates of disability and mortality. The urgency of the problem of cerebrovascular diseases can rightfully be defined as extraordinary, requiring the concentration of efforts of specialists of different profiles to solve it. Subtotal cerebral ischemia leads to the development of morpho functional disturbances of the cerebral cortex. The introduction of Omega-3 polyunsaturated fatty acids has a corrective effect on the hippocampus in conditions of subtotal ischemia, reducing the number of shadow cells and hyperchromic shrunken neurons, without significantly affecting the size and shape of neurons in the cerebral cortex. Prior administration of L-NAME, the use of Omega-3 did not prevent the effects of the NO synthase inhibitor and associated NO deficiency at this dose and route of administration.","PeriodicalId":72287,"journal":{"name":"Archives of nephrology and urology","volume":"55 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87468539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
An antibiotic is a type of antimicrobial substance active against bacteria. It is the most important type of antibacterial agent for fighting bacterial infections, and antibiotic medications are widely used in the treatment and prevention of such infections.[1][2] They may either kill or inhibit the growth of bacteria. A limited number of antibiotics also possess antiprotozoal activity.[3][4] Antibiotics are not effective against viruses such as the common cold or influenza;[5] drugs which inhibit viruses are termed antiviral drugs or antivirals rather than antibiotics.
{"title":"Impact of Appropriate Antibiotics within 1hr of Patients Admission","authors":"S. Biswas","doi":"10.58489/2836-5828/006","DOIUrl":"https://doi.org/10.58489/2836-5828/006","url":null,"abstract":"An antibiotic is a type of antimicrobial substance active against bacteria. It is the most important type of antibacterial agent for fighting bacterial infections, and antibiotic medications are widely used in the treatment and prevention of such infections.[1][2] They may either kill or inhibit the growth of bacteria. A limited number of antibiotics also possess antiprotozoal activity.[3][4] Antibiotics are not effective against viruses such as the common cold or influenza;[5] drugs which inhibit viruses are termed antiviral drugs or antivirals rather than antibiotics.","PeriodicalId":72287,"journal":{"name":"Archives of nephrology and urology","volume":"120 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72502111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anoxia as an extreme degree of acute oxygen starvation of the brain cells, regardless of the causes, leads to its greatest damage. As a result of using a new model of cerebral anoxia we have established disturbances in the parietal cortex of the rat brain, manifested by changes in the size, shape of neurons, the degree of their chromatophilia. This indicates the possibility of using the method of modeling anoxia by tracheal compression to study acute cerebral oxygen deficiency. It provides an opportunity to assess visually the dynamics of neuronal changes under anoxia without shutting down the cerebral circulation. It may be of value for further study of the consequences of disorders in the brain arising from respiratory pathology and external causes accompanied by asphyxia.
{"title":"Modeling of Cerebral Anoxia of Respiratory Genesis in Rats","authors":"E. Bon'","doi":"10.58489/2836-5828/003","DOIUrl":"https://doi.org/10.58489/2836-5828/003","url":null,"abstract":"Anoxia as an extreme degree of acute oxygen starvation of the brain cells, regardless of the causes, leads to its greatest damage. As a result of using a new model of cerebral anoxia we have established disturbances in the parietal cortex of the rat brain, manifested by changes in the size, shape of neurons, the degree of their chromatophilia. This indicates the possibility of using the method of modeling anoxia by tracheal compression to study acute cerebral oxygen deficiency. It provides an opportunity to assess visually the dynamics of neuronal changes under anoxia without shutting down the cerebral circulation. It may be of value for further study of the consequences of disorders in the brain arising from respiratory pathology and external causes accompanied by asphyxia.","PeriodicalId":72287,"journal":{"name":"Archives of nephrology and urology","volume":"285 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79552324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Oxidative reactions and the substances formed as a result of their course are important in the vital activity of the cells of the whole organism and the brain, in particular. It has been established that oxygen radicals function as a messenger, responsible for neuronal activity, regulate cerebral blood flow, apoptosis and other processes necessary for the functioning of the brain. It has been shown that nerve impulse conduction is also associated with the formation of free-radical forms of phospholipids. The purpose of this article is to summarize and systematize literature data on the mechanisms of oxidative stress and describe the method for studying it in modeling experimental cerebral pathology. Oxidative stress, which is the result of an imbalance between prooxidants and antioxidants towards the former due to excessive production of free radicals and/or a decrease in the activity of antioxidant defense, underlies the pathogenesis of many diseases and its study in modeling experimental pathology serves as a fundamental basis for clinical research.
{"title":"Oxidative Stress and Methods of Its Determination in Experimental Brain Pathology","authors":"Bon L.I.","doi":"10.58489/2836-5828/002","DOIUrl":"https://doi.org/10.58489/2836-5828/002","url":null,"abstract":"Oxidative reactions and the substances formed as a result of their course are important in the vital activity of the cells of the whole organism and the brain, in particular. It has been established that oxygen radicals function as a messenger, responsible for neuronal activity, regulate cerebral blood flow, apoptosis and other processes necessary for the functioning of the brain. It has been shown that nerve impulse conduction is also associated with the formation of free-radical forms of phospholipids. The purpose of this article is to summarize and systematize literature data on the mechanisms of oxidative stress and describe the method for studying it in modeling experimental cerebral pathology. Oxidative stress, which is the result of an imbalance between prooxidants and antioxidants towards the former due to excessive production of free radicals and/or a decrease in the activity of antioxidant defense, underlies the pathogenesis of many diseases and its study in modeling experimental pathology serves as a fundamental basis for clinical research.","PeriodicalId":72287,"journal":{"name":"Archives of nephrology and urology","volume":"43 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84139937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Rapid initiation of antibiotic treatment is considered crucial in patients with severe infections such as septic shock & bacterial meningitis. The initiation of treatment with inappropriate antimicrobial agents (in relation to the subsequently demonstrated sensitivity of the pathogen) as the initial empiric therapy may be the single most common cause of prolonged delays in the introduction of effective therapy. Only in 5% of cases were antibiotics administered within 1 hr of the decision making, in 47% of cases it took 1–2 hrs. Only in 33% of cases antibiotics were prescribed within one hour of decision making. In 95% of cases antibiotics were administered within one hour of prescription. Sepsis is the main cause of death in patients treated in intensive care units (ICU). Current sepsis guidelines recommend administration of antibiotics within one hour of ED triage. However, the quality of supporting evidence is moderate & studied have shown mixed results regarding the association between antibiotics administration timing & outcome in septic shock. Objective:The aim of this study was to assess whether timing of administration of appropriate antibiotics within one hour of admission to the ICU impact patient outcomes. Method: Timing of ICU admission noted from the patient’s ICU nursing chart when the first vital parameters are noted by the nurse. Timing of administration of 1st dose of antibiotic and antibiotic that is administered within the first one hour of admission is noted from ICU nursing chart (in minutes from the timing of ICU admission). Appropriateness of antibiotic is assessed from the microbiology culture and sensitivity result. Outcome measures is noted from the ICU database. Data is then recorded systemically in the data collection form and finally entered in the excel sheet for analysis. All the data is then analysed by statistician by appropriate statistical tests. Result: A total of 53 patients, including 63.2% in the sepsis group and 53.4% in the septic shock group received antibiotics within the first hour. 87.5 % patients who received antibiotic within one hour of admission were discharged compared to 81.0% patients who received first dose of antibiotic beyond one hour of admission. The commonest gram-negative organisms were E. coli and Klebsiella in both groups. The commonest antibiotic administered was Meropenem in both groups. All patients who received appropriate antibiotic were discharged compared with only 69.2% patients discharged whose antibiotic choice was inappropriate. Mortality was 30.8% in the group whose initial antibiotic choice was inappropriate while no patients died in the group where the patient received appropriate empirical therapy. Conclusion: In my study it is demonstrated that gram-negative bacteria remain the major pathogen in sepsis as has been demonstrated in most ICUs in India. When appropriateness as well as timing of administration were compared simultaneously, all patients who received
{"title":"Impact of Appropriate Antibiotics within One Hour and Patients' Outcome: A Study and Review","authors":"S. Biswas","doi":"10.58489/2836-5828/005","DOIUrl":"https://doi.org/10.58489/2836-5828/005","url":null,"abstract":"Background: Rapid initiation of antibiotic treatment is considered crucial in patients with severe infections such as septic shock & bacterial meningitis. The initiation of treatment with inappropriate antimicrobial agents (in relation to the subsequently demonstrated sensitivity of the pathogen) as the initial empiric therapy may be the single most common cause of prolonged delays in the introduction of effective therapy. Only in 5% of cases were antibiotics administered within 1 hr of the decision making, in 47% of cases it took 1–2 hrs. Only in 33% of cases antibiotics were prescribed within one hour of decision making. In 95% of cases antibiotics were administered within one hour of prescription. Sepsis is the main cause of death in patients treated in intensive care units (ICU). Current sepsis guidelines recommend administration of antibiotics within one hour of ED triage. However, the quality of supporting evidence is moderate & studied have shown mixed results regarding the association between antibiotics administration timing & outcome in septic shock. Objective:The aim of this study was to assess whether timing of administration of appropriate antibiotics within one hour of admission to the ICU impact patient outcomes. Method: Timing of ICU admission noted from the patient’s ICU nursing chart when the first vital parameters are noted by the nurse. Timing of administration of 1st dose of antibiotic and antibiotic that is administered within the first one hour of admission is noted from ICU nursing chart (in minutes from the timing of ICU admission). Appropriateness of antibiotic is assessed from the microbiology culture and sensitivity result. Outcome measures is noted from the ICU database. Data is then recorded systemically in the data collection form and finally entered in the excel sheet for analysis. All the data is then analysed by statistician by appropriate statistical tests. Result: A total of 53 patients, including 63.2% in the sepsis group and 53.4% in the septic shock group received antibiotics within the first hour. 87.5 % patients who received antibiotic within one hour of admission were discharged compared to 81.0% patients who received first dose of antibiotic beyond one hour of admission. The commonest gram-negative organisms were E. coli and Klebsiella in both groups. The commonest antibiotic administered was Meropenem in both groups. All patients who received appropriate antibiotic were discharged compared with only 69.2% patients discharged whose antibiotic choice was inappropriate. Mortality was 30.8% in the group whose initial antibiotic choice was inappropriate while no patients died in the group where the patient received appropriate empirical therapy. Conclusion: In my study it is demonstrated that gram-negative bacteria remain the major pathogen in sepsis as has been demonstrated in most ICUs in India. When appropriateness as well as timing of administration were compared simultaneously, all patients who received","PeriodicalId":72287,"journal":{"name":"Archives of nephrology and urology","volume":"75 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86792013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: To determine the association of estimated Glomerular Filtration Rate (eGFR) with HbA1c and microvascular complications in patients with type 2 diabetes. Study design, settings & duration: This retrospective study was based on a hospital data record of patients visiting the outpatient department of Baqai Institute of Diabetology and Endocrinology, Baqai Medical University from January 2018 to October 2018. Methodology: Data was obtained from hospital management system (HMS). Records of Patients with type 2 diabetes having data on eGFR were included. Calculation of eGFR was done by MDRD formula. Following clinical practice guideline (KIDGO) eGFR was grouped into five GFR Categories of CKD Stage 1, 2, 3, 4 and 5. Results: Total of 3165 patients, 1773 (56%) males and 1392 (44%) females with type 2 diabetes were recruited. Mean age of patients was 50.4±10.84 years. Frequency of patients were higher 57.7% in eGFR category 2 (60-89 ml/min/1.73 m 2 ) and 32.1% eGFR category 3 (30-59 ml/min/1.73 m 2 ). Very low eGFR (<15 ml/min/1.73 m 2 ) was significantly associated with reduction of glycated HbA1c (%) and HDL-Cholesterol. While, decreased eGFR was significantly (p <0.0001) associated with increased risk of diabetic nephropathy, neuropathy, retinopathy and hypertension. Conclusion: Overall, eGFR reduction especially in combination with longer disease duration is significantly associated with decreased HbA1c but increased risks of microvascular complications in patients with type 2 diabetes.
{"title":"Association of Estimated Glomerular Filtration Rate with Hba1c and Microvascular Complications in Type 2 Diabetes","authors":"Salman Tariq, Nabeel Yousaf Chaudhary, Talha Ibad, Mahrukh Naeem, Jawiria Javid, Sajeela Riaz","doi":"10.26502/anu.2644-2833064","DOIUrl":"https://doi.org/10.26502/anu.2644-2833064","url":null,"abstract":"Objective: To determine the association of estimated Glomerular Filtration Rate (eGFR) with HbA1c and microvascular complications in patients with type 2 diabetes. Study design, settings & duration: This retrospective study was based on a hospital data record of patients visiting the outpatient department of Baqai Institute of Diabetology and Endocrinology, Baqai Medical University from January 2018 to October 2018. Methodology: Data was obtained from hospital management system (HMS). Records of Patients with type 2 diabetes having data on eGFR were included. Calculation of eGFR was done by MDRD formula. Following clinical practice guideline (KIDGO) eGFR was grouped into five GFR Categories of CKD Stage 1, 2, 3, 4 and 5. Results: Total of 3165 patients, 1773 (56%) males and 1392 (44%) females with type 2 diabetes were recruited. Mean age of patients was 50.4±10.84 years. Frequency of patients were higher 57.7% in eGFR category 2 (60-89 ml/min/1.73 m 2 ) and 32.1% eGFR category 3 (30-59 ml/min/1.73 m 2 ). Very low eGFR (<15 ml/min/1.73 m 2 ) was significantly associated with reduction of glycated HbA1c (%) and HDL-Cholesterol. While, decreased eGFR was significantly (p <0.0001) associated with increased risk of diabetic nephropathy, neuropathy, retinopathy and hypertension. Conclusion: Overall, eGFR reduction especially in combination with longer disease duration is significantly associated with decreased HbA1c but increased risks of microvascular complications in patients with type 2 diabetes.","PeriodicalId":72287,"journal":{"name":"Archives of nephrology and urology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69345187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.26502/anu.2644-2833057
S. Allen, Muhammad Akram, A. Adjani, S. Kamal, A. Rashid, Akram Malik, M. Khalil, Sherwani Rehan.
{"title":"Thermobalancing therapy with Dr Allen's Device dissolves kidney stones improving health-related quality of life measured by the Wisconsin Stone Quality of Life questionnaire (WISQOL) – a randomised clinical trial","authors":"S. Allen, Muhammad Akram, A. Adjani, S. Kamal, A. Rashid, Akram Malik, M. Khalil, Sherwani Rehan.","doi":"10.26502/anu.2644-2833057","DOIUrl":"https://doi.org/10.26502/anu.2644-2833057","url":null,"abstract":"","PeriodicalId":72287,"journal":{"name":"Archives of nephrology and urology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69345103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.26502/anu.2644-2833062
R. Coşar, Ulku Korkmaz, N. Sut, A. Ozen
{"title":"Scintigraphic and Histopathologic Evaluation of the Protective Effect of L-Carnitine on the Development of Radiation-Induced Kidney Damage in Infant Rats","authors":"R. Coşar, Ulku Korkmaz, N. Sut, A. Ozen","doi":"10.26502/anu.2644-2833062","DOIUrl":"https://doi.org/10.26502/anu.2644-2833062","url":null,"abstract":"","PeriodicalId":72287,"journal":{"name":"Archives of nephrology and urology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69345176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.26502/anu.2644-2833069
Dhar S, Iqbal MM, Debnath DK, Hussain MZ, Mahmud MA, Sarker S, Uddin MR, Khatun MA, Mekhola MH, Rahman AKMS
Mineral and bone disorder (MBD) in chronic kidney disease (CKD) is associated with increased morbidity and mortality. The CKDMBD syndrome is comprised of biochemical abnormalities, vascular calcification, and bone fragility, and each is consistently associated with elevated risks for morbidity and mortality across the spectrum of CKD. This study was aimed to assess the biochemical markers of mineral bone disorder in chronic kidney disease patients on maintenance hemodialysis. This cross-sectional study was conducted at National Institute of Kidney Diseases and Urology (NIKDU), Dhaka, Bangladesh from March 2022 to September 2022. A total of 160 cases with end-stage renal disease (ESRD) on maintenance hemodialysis (MHD) were enrolled. Demographic profile, detailed case history with clinical examination findings of each study patient was recorded and relevant investigations were done accordingly. The mean age of the study patients was 45.9±12.4 years and their mean duration of dialysis was 2.0±0.8 years. Maintained intact parathyroid hormone (iPTH) was in 55% of study patients and maintained bone alkaline phosphatase (BALP) was in 83.7% of study patients. Total 20.6% of study patients had high turnover and 24.4% had low turnover bone disease according to iPTH. Most of the study participants had history of taking oral phosphate binder, calcium and activated form of vitamin D. Among the total participants, 8.1% had hypocalcemia, 46.9% had hypercalcemia, 56.9% had hyperphosphatemia, 15.6% had hypophosphatemia, and 77.5% had vitamin D deficiency. This study concluded that, abnormalities of biochemical markers of mineral bone disorder are common in maintenance hemodialysis patients despite of oral supplementation.
{"title":"Biochemical Markers of Mineral Bone Disorder in Chronic Kidney Disease Patients on Maintenance Hemodialysis","authors":"Dhar S, Iqbal MM, Debnath DK, Hussain MZ, Mahmud MA, Sarker S, Uddin MR, Khatun MA, Mekhola MH, Rahman AKMS","doi":"10.26502/anu.2644-2833069","DOIUrl":"https://doi.org/10.26502/anu.2644-2833069","url":null,"abstract":"Mineral and bone disorder (MBD) in chronic kidney disease (CKD) is associated with increased morbidity and mortality. The CKDMBD syndrome is comprised of biochemical abnormalities, vascular calcification, and bone fragility, and each is consistently associated with elevated risks for morbidity and mortality across the spectrum of CKD. This study was aimed to assess the biochemical markers of mineral bone disorder in chronic kidney disease patients on maintenance hemodialysis. This cross-sectional study was conducted at National Institute of Kidney Diseases and Urology (NIKDU), Dhaka, Bangladesh from March 2022 to September 2022. A total of 160 cases with end-stage renal disease (ESRD) on maintenance hemodialysis (MHD) were enrolled. Demographic profile, detailed case history with clinical examination findings of each study patient was recorded and relevant investigations were done accordingly. The mean age of the study patients was 45.9±12.4 years and their mean duration of dialysis was 2.0±0.8 years. Maintained intact parathyroid hormone (iPTH) was in 55% of study patients and maintained bone alkaline phosphatase (BALP) was in 83.7% of study patients. Total 20.6% of study patients had high turnover and 24.4% had low turnover bone disease according to iPTH. Most of the study participants had history of taking oral phosphate binder, calcium and activated form of vitamin D. Among the total participants, 8.1% had hypocalcemia, 46.9% had hypercalcemia, 56.9% had hyperphosphatemia, 15.6% had hypophosphatemia, and 77.5% had vitamin D deficiency. This study concluded that, abnormalities of biochemical markers of mineral bone disorder are common in maintenance hemodialysis patients despite of oral supplementation.","PeriodicalId":72287,"journal":{"name":"Archives of nephrology and urology","volume":"112 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136002825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Angiotensin-converting enzyme 2 has been identified as the receptor that allows the entry of SarsCov2 into the human cell. Its expression in the kidney is 100 times higher than in the lung; thus, making the kidney an excellent target for SarsCov2 infection manifesting as renal failure (RF). The objective of this study was to determine the predictive factors of RF during covid-19 in the Togolese context.
{"title":"Predictive Factors of Renal Failure in Covid 19 Patients at the Anti-Covid Center in Lome, Togo","authors":"Kossi Akomola SABI, Awéréou KOTOSSO, Yoan Makafui AMEKOUDI","doi":"10.26502/anu.2644-2833070","DOIUrl":"https://doi.org/10.26502/anu.2644-2833070","url":null,"abstract":"Background: Angiotensin-converting enzyme 2 has been identified as the receptor that allows the entry of SarsCov2 into the human cell. Its expression in the kidney is 100 times higher than in the lung; thus, making the kidney an excellent target for SarsCov2 infection manifesting as renal failure (RF). The objective of this study was to determine the predictive factors of RF during covid-19 in the Togolese context.","PeriodicalId":72287,"journal":{"name":"Archives of nephrology and urology","volume":"148 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134889438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：