Archives of rehabilitation research and clinical translation最新文献

{"title":"Resiliency and Mental Health Symptoms Among Active Duty Service Members With a History of Mild Traumatic Brain Injury","authors":"Rosemay A. Remigio-Baker PhD, MPH ,&nbsp;Lars D. Hungerford PhD ,&nbsp;Donald Marion MD ,&nbsp;Grace L. Reveles RN ,&nbsp;Angela G. Basham MPH ,&nbsp;Keith Stuessi MD ,&nbsp;Juan Lopez BA ,&nbsp;Jason M. Bailie PhD","doi":"10.1016/j.arrct.2025.100480","DOIUrl":"10.1016/j.arrct.2025.100480","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the associations between resilience and emotional symptoms among service members (SMs) with mild traumatic brain injury (mTBI) and determine whether these relationships vary by the number of lifetime mTBI.</div></div><div><h3>Design</h3><div>Cross-sectional.</div></div><div><h3>Setting</h3><div>Southwestern US military interdisciplinary traumatic brain injury (TBI) facility</div></div><div><h3>Participants</h3><div>N=230 SMs being treated for mTBI (92.2% of men, with a mean age of 33.8 years [SD, 8.8] and 13.5 years in active duty [SD, 8.3], and a median of 64.9 months from injury to intake).</div></div><div><h3>Interventions</h3><div>Not applicable; however, overall resilience (categorized as low, moderate, and high) and 5 themes (meaning-making and restoration, active coping, cognitive flexibility, spirituality, and self-efficacy) were measured using the Response to Stressful Experiences Scale.</div></div><div><h3>Main Outcome Measures</h3><div>Clinically elevated posttraumatic stress (PTS) and depressive symptoms were measured using the Posttraumatic Stress Disorder Checklist for Diagnostic and Statistical Manual of Mental Disorders, Fifth Ediction (score≥33) and the 8-item Patient Health Questionnaire (score≥15), respectively. The number of lifetime mTBI (single vs multiple) was ascertained using the Ohio State University TBI Identification Method and evaluated as an interaction term.</div></div><div><h3>Results</h3><div>SMs with higher (vs lower) overall resilience levels were significantly less likely to have clinically elevated PTS and depressive symptoms at pretreatment. These associations did not vary by the number of lifetime mTBIs. By resilience themes, higher levels were associated with a lower likelihood of clinically elevated PTS and depressive symptoms at pretreatment, but for active coping and cognitive flexibility, the relationship with depressive symptoms was only significant among those with a single mTBI. No significant results were found at posttreatment.</div></div><div><h3>Conclusions</h3><div>The findings may be helpful to inform expectations of recovery and optimal management of symptoms. Future longitudinal studies are needed to evaluate the effect of resilience on mental health issues and why it may not be beneficial in the presence of multiple mTBIs.</div></div>","PeriodicalId":72291,"journal":{"name":"Archives of rehabilitation research and clinical translation","volume":"7 3","pages":"Article 100480"},"PeriodicalIF":2.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145011246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive and Psychological Symptoms in Post-COVID-19 Condition: A Systematic Review of Structural and Functional Neuroimaging, Neurophysiology, and Intervention Studies","authors":"Eva Pettemeridou PhD ,&nbsp;Maria Loizidou MSc ,&nbsp;Jelena Trajkovic PhD ,&nbsp;Maria Constantinou PhD ,&nbsp;Stefanie De Smet MSc ,&nbsp;Chris Baeken PhD ,&nbsp;Alexander T. Sack PhD ,&nbsp;Steven C.R. Williams PhD ,&nbsp;Fofi Constantinidou PhD","doi":"10.1016/j.arrct.2025.100461","DOIUrl":"10.1016/j.arrct.2025.100461","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the structural, functional, and neurophysiological brain changes associated with post-COVID-19 condition (PCC)-related cognitive and psychological issues and evaluate the efficacy of noninvasive brain stimulation (NIBS) and cognitive rehabilitation interventions.</div></div><div><h3>Data Sources</h3><div>Electronic databases, including Web of Science, PubMed, and Embase, were systematically searched for articles published before February 1, 2025, using terms such as “post-COVID-19 condition,” “cognitive dysfunction,” “brain changes,” “noninvasive brain stimulation,” and “cognitive rehabilitation.” Language was restricted to English, and only studies involving human participants were included.</div></div><div><h3>Study Selection</h3><div>Studies with human participants aged ≥18 years diagnosed with PCC, employing magnetic resonance imaging, functional magnetic resonance imaging, positron emission tomography, and electroencephalography, and interventions such as NIBS and cognitive rehabilitation were included. Articles were selected through independent review by multiple authors, with consensus resolving discrepancies. Of the 123 studies initially identified, 78 met the inclusion criteria.</div></div><div><h3>Data Extraction</h3><div>Data on participant demographics, methodologies, neurophysiological changes, and intervention outcomes were extracted by 2 independent reviewers using predefined guidelines. Study quality was assessed using the Newcastle-Ottawa Scale and Critical Appraisal Skills Program tools.</div></div><div><h3>Data Synthesis</h3><div>Seventy-eight studies with over 5900 participants met the inclusion criteria. Significant cognitive impairments were observed in attention, executive function, and memory (N=78). Key findings included mixed evidence of gray matter (N=16) and white matter volume changes (N=20), cortical thickness alterations (N=9), variations in functional connectivity (N=14), electrophysiology (N=9), and blood flow (N=8). NIBS, including transcranial magnetic stimulation (N=8) and transcranial direct current stimulation (N=2), showed potential benefits for managing depression and cognitive impairments. Although cognitive rehabilitation (N=3) showed promise, it requires further investigation.</div></div><div><h3>Conclusions</h3><div>This review highlights the complex neurologic underpinnings of PCC and the potential of NIBS and cognitive rehabilitation as interventions. Further research is essential to refine these interventions and establish evidence-based strategies for addressing long-term cognitive and psychological effects of PCC.</div></div>","PeriodicalId":72291,"journal":{"name":"Archives of rehabilitation research and clinical translation","volume":"7 3","pages":"Article 100461"},"PeriodicalIF":2.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145011266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Impact of Muscle Vibration Therapy in Neurologic Rehabilitation: A Systematic Review","authors":"Andrea Calderone MSc ,&nbsp;Svonko Galasso PhD ,&nbsp;Alessandro Marco De Nunzio PhD ,&nbsp;Antonio Leo PhD ,&nbsp;Tina Balletta PhD ,&nbsp;Angelo Quartarone PhD ,&nbsp;Rocco Salvatore Calabrò PhD","doi":"10.1016/j.arrct.2025.100478","DOIUrl":"10.1016/j.arrct.2025.100478","url":null,"abstract":"<div><h3>Objective</h3><div>To consolidate evidence on the efficacy of muscle vibration therapy for neurorehabilitation, providing health care practitioners with insights for enhancing treatment protocols and guiding future research.</div></div><div><h3>Data Sources</h3><div>Studies were identified from an online search of PubMed, Web of Science, and Embase databases, with a search time range of 2014-2024.</div></div><div><h3>Study Selection</h3><div>A total of 26 studies involving 787 individuals were included in this systematic review, including diverse neurologic conditions and intervention protocols.</div></div><div><h3>Data Extraction</h3><div>Keywords, Boolean operators, and controlled vocabulary were combined and tested in a gradual and iterative manner to achieve the highest possible sensitivity and specificity. The PRISMA flowchart was used to depict the process of selecting relevant studies.</div></div><div><h3>Data Synthesis</h3><div>Research on segmental and local muscle vibration in upper limb rehabilitation for poststroke patients is promising, as it can improve motor function, decrease spasticity, and enhance muscle control. Whole-body vibration interventions also show advantages in lower limb spasticity and balance, with specific studies adducing better results when paired with task-specific training. Vibration therapy has shown promising outcomes for alleviating pain, managing spasticity, and improving motor function in various neurologic conditions such as SCI and cerebral palsy, highlighting its potential in treating different neurologic disorders.</div></div><div><h3>Conclusions</h3><div>This review emphasizes the potential of muscle vibration therapy in neurorehabilitation, showing benefits in motor control, spasticity, and functional outcomes, while underscoring the importance of rigorous methods and further extensive research to improve result dependability.</div></div>","PeriodicalId":72291,"journal":{"name":"Archives of rehabilitation research and clinical translation","volume":"7 3","pages":"Article 100478"},"PeriodicalIF":2.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145011265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Community-Based Rehabilitation and Patient-Centered Outcomes in Survivors of Critical COVID-19 Attending an Intensive Care Recovery Clinic","authors":"Felipe González-Seguel PT, MS ,&nbsp;Evan Haezebrouck PT, DPT ,&nbsp;Lindsey E. Fresenko PT, PhD ,&nbsp;Carla M. Sevin MD ,&nbsp;Stacey Slone MS ,&nbsp;Ashley Montgomery-Yates MD ,&nbsp;Anna G. Kalema MD ,&nbsp;Lori Ginoza PT ,&nbsp;Clarisa Martinez PT, DPT, MS ,&nbsp;Michelle Biehl MD ,&nbsp;Soibhan R. Kelley MD ,&nbsp;Joshua K. Johnson PT, DPT, PhD ,&nbsp;Matthew F. Mart MD, MSc ,&nbsp;Kirby P. Mayer PT, DPT, PhD","doi":"10.1016/j.arrct.2025.100484","DOIUrl":"10.1016/j.arrct.2025.100484","url":null,"abstract":"<div><h3>Objective</h3><div>To examine the occurrence of physical and cognitive impairments among survivors of critical coronavirus disease of 2019 (COVID-19) who attend an intensive care unit (ICU) recovery clinic and describe their utilization of community-based rehabilitation (physical and occupational therapy).</div></div><div><h3>Design</h3><div>Retrospective, observational cohort study and multisite practice analysis.</div></div><div><h3>Setting</h3><div>ICU recovery clinics at 4 academic medical centers.</div></div><div><h3>Participants</h3><div>Adults (median age 56 [interquartile range, {IQR}, 47–64] years, 60% female) surviving acute respiratory failure caused by COVID-19 who required advanced respiratory support.</div></div><div><h3>Main outcome measures</h3><div>Six-minute walk test (6MWT) and Montreal Cognitive Assessment (MoCA).</div></div><div><h3>Results</h3><div>Patients attended the ICU recovery clinic (n=163) in a median of 43 (IQR, 30-60) days after discharge. Ninety-four patients (58%) participated in at least 1 community-based rehabilitation session, 52 (32%) never participated, and 17 (10%) did not have data available. Patients walked a median [IQR] of 282 [150-390] meters on the 6MWT, and the median Short Physical Performance Battery (SPPB) score was 8 [4-11] with 63% of patients classified as physically frail (score ≤9/12). The median MoCA score was 26 [22-27], with 37% at least mild cognitive impairment (score of ≤26). Among patients who were driving before ICU admission, 44% had not returned to driving after hospitalization, and an additional 21% reported driving with new limitations. Patients who participated in at least 1 community-based rehabilitation session had longer ICU lengths of stay as well as worse performance on the 6MWT and SPPB at discharge compared with individuals not receiving postdischarge rehabilitation (<em>P</em>&lt;.001).</div></div><div><h3>Conclusions</h3><div>Survivors of acute respiratory failure caused by critical COVID-19 who attended an ICU recovery clinic are at high risk of physical and/or cognitive impairments. Two-thirds of survivors participated in physical or occupational therapy at home or an outpatient center after hospital discharge. Patients with longer lengths of stay and more physical impairments at discharge are more likely to participate in community-based rehabilitation interventions.</div></div>","PeriodicalId":72291,"journal":{"name":"Archives of rehabilitation research and clinical translation","volume":"7 3","pages":"Article 100484"},"PeriodicalIF":2.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145009898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Remotely Delivered Task-Oriented Training and Evaluation (reTOTE) for Stroke Rehabilitation","authors":"Veronica T. Rowe PhD, OTR/L ,&nbsp;Emily A. Wilcox MHS, OTR/L ,&nbsp;Charlotte A. Chatto PT, PhD ,&nbsp;Ryan M. Carrick PhD, MHS, OTR/L","doi":"10.1016/j.arrct.2025.100491","DOIUrl":"10.1016/j.arrct.2025.100491","url":null,"abstract":"<div><h3>Objective</h3><div>To determine the effect of a multifaceted task-oriented training intervention delivered through telerehabilitation (Remote Task-Oriented Training and Evaluation [reTOTE]) on stroke survivors’ activity, performance, quality of life, and confidence.</div></div><div><h3>Design</h3><div>Cohort study with repeated measures at pre- and post-reTOTE intervention and 1-month follow-up.</div></div><div><h3>Setting</h3><div>Virtual through telerehabilitation.</div></div><div><h3>Participants</h3><div>Twelve (N=12) stroke survivors.</div></div><div><h3>Interventions</h3><div>The reTOTE intervention was individualized for each participant during 8 sessions designed with evidence-based components of constraint-induced movement therapy, principles of experience-dependent plasticity, and use of the Cognitive Orientation to daily Occupational Performance approach.</div></div><div><h3>Main Outcome Measures</h3><div>Motor Activity Log, Canadian Occupational Performance Measure, Stroke Impact Scale, and the Activities-specific Balance Confidence Scale.</div></div><div><h3>Results</h3><div>The results demonstrated an increase in performance of functional abilities in stroke survivors’ lives immediately and at 1-month follow-up after completing reTOTE compared with preintervention.</div></div><div><h3>Conclusions</h3><div>This study indicates the importance of using an evidence-based, individualized, task-oriented therapeutic intervention for stroke survivors and the feasibility of remote delivery through telerehabilitation. Implementation of reTOTE may allow for access to rehabilitation that could improve meaningful therapeutic outcomes for stroke survivors.</div></div>","PeriodicalId":72291,"journal":{"name":"Archives of rehabilitation research and clinical translation","volume":"7 3","pages":"Article 100491"},"PeriodicalIF":2.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145009900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transition Aged Individuals With Cerebral Palsy Have Larger Clinical Gains With Visual Performance Feedback During Power Training","authors":"Brad Corr PT, DPT, PhD ,&nbsp;Heidi Reelfs PT ,&nbsp;Michael Trevarrow PhD ,&nbsp;Sarah Baker MA ,&nbsp;Max J. Kurz PhD","doi":"10.1016/j.arrct.2025.100463","DOIUrl":"10.1016/j.arrct.2025.100463","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate if providing visual feedback (VFB) on the speed of the movement during a lower extremity power training treatment protocol results in greater clinical gains in transition aged individuals with cerebral palsy (CP).</div></div><div><h3>Design</h3><div>Nonrandomized controlled trial.</div></div><div><h3>Setting</h3><div>Academic medical center.</div></div><div><h3>Participants</h3><div>Twenty transition aged persons (N=20) with CP (age range, 11-24y; Gross Motor Function Classification Score [GMFCS], I-IV).</div></div><div><h3>Interventions</h3><div>Twenty-four (8wks; 3d/wk) lower extremity power training sessions while receiving either VFB of their performance or no feedback (NFB) on their performance.</div></div><div><h3>Main Outcome Measures</h3><div>Bilateral leg press 1-repetition maximum (1RM), bilateral leg peak power production and walking speed reserve.</div></div><div><h3>Results</h3><div>The VFB group had greater lower extremity strength gains than the NFB group (<em>P</em>=.026). Additionally, the 1RM clinical gains were dependent on the baseline 1RM (<em>P</em>&lt;.001). The VFB group also had greater lower extremity power production after power training (<em>P</em>=.009). The extent of the power production gains was partially dependent on the baseline power production (<em>P</em>&lt;.001). The VFB group also had a larger walking speed reserve after the treatment (<em>P</em>=.039). However, the extent of the walking speed reserve gains was linked with an individual’s GMFCS level (<em>P</em>&lt;.001).</div></div><div><h3>Conclusions</h3><div>VFB during power training has the potential to results in larger clinical gains for transition aged individuals with CP. Individuals with higher GMFCS levels, lower muscular strength and muscular power at baseline might not demonstrate as large of gains after power training even when VFB is provided. Alternative treatment strategies should be considered for these cases. Nevertheless, our results convey that learning to perform fast lower extremity motor actions likely has clinically relevant benefits for transition aged individuals with CP.</div></div>","PeriodicalId":72291,"journal":{"name":"Archives of rehabilitation research and clinical translation","volume":"7 3","pages":"Article 100463"},"PeriodicalIF":2.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145011242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating Disparities in Physical Therapy Utilization: An Intersectionality Perspective","authors":"Lauren Rimmel PT, DPT ,&nbsp;Kathleen Taglieri-Noble PT, DPT ,&nbsp;Rebecca Pham PT, DPT ,&nbsp;Joseph Tolland PT, DPT ,&nbsp;Saloni Doshi PT, DPT ,&nbsp;Nicholas Capobianco PT, DPT ,&nbsp;Anshul Kumar PhD","doi":"10.1016/j.arrct.2025.100465","DOIUrl":"10.1016/j.arrct.2025.100465","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the role of race, ethnicity, language, insurance payor, and socioeconomic status, both individually and through an intersectional framework, on outpatient physical therapy (PT) utilization. A secondary aim was to examine the differences in scheduling and attendance based on the aforementioned factors.</div></div><div><h3>Design</h3><div>A retrospective cohort study examining outpatient PT referrals, scheduled appointments, and attendance. Data included the status of visit completion, race, ethnicity, language, insurance payor, and zip code. Multiple logistic regression models, with and without interaction terms, analyzed the association of demographic factors with outcomes of interest.</div></div><div><h3>Setting</h3><div>This retrospective cohort study collected data between July 2021 and July 2022 from electronic medical records within a large academic medical system in New England.</div></div><div><h3>Participants</h3><div>N=61,125.</div></div><div><h3>Interventions</h3><div>Not applicable.</div></div><div><h3>Main Outcome Measures</h3><div>This study assessed 3 outcomes. Outcome 1 analyzed the rates of scheduling after referral. Outcome 2 analyzed the rates of attendance after scheduling. Outcome 3 analyzed the rates of attendance after referral.</div></div><div><h3>Results</h3><div>Race, language, and income were associated with differences in scheduling versus attending PT. Black or African American patients showed the highest appointment-making rates and lowest attendance rates after scheduling compared with White patients. Asian patients demonstrated the lowest appointment-making rates and highest attendance rates after scheduling compared with White patients. Non-English-speaking patients were less likely to schedule and attend PT compared with English-speaking patients. Higher socioeconomic status was associated with higher rates of scheduling and attendance. Further disparities were noted when examining the interaction of variables. Increasing income benefited most, but not all groups. Black or African American patients experienced a decrease in scheduling and attendance rates with rising income compared with White patients. Non-English-speaking patients experienced less of an increase in scheduling and attendance rates with rising income compared with English-speaking patients.</div></div><div><h3>Conclusions</h3><div>Findings highlighted disparities in PT utilization in scheduling and attendance with regard to race, language, and income. Disparities were amplified when examining interactions between race and income and language and income, underscoring the importance of an intersectional analysis.</div></div>","PeriodicalId":72291,"journal":{"name":"Archives of rehabilitation research and clinical translation","volume":"7 3","pages":"Article 100465"},"PeriodicalIF":2.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145011243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor on “Effectiveness of early cardiorespiratory rehabilitation combined with melatonin supplementation during the inpatient period following acute myocardial infarction.”","authors":"Amine Ghram PhD (Clinical Exercise Physiologist, AACVPR-CCRP),&nbsp;Helmi Ben Saad MD, PhD","doi":"10.1016/j.arrct.2025.100476","DOIUrl":"10.1016/j.arrct.2025.100476","url":null,"abstract":"","PeriodicalId":72291,"journal":{"name":"Archives of rehabilitation research and clinical translation","volume":"7 3","pages":"Article 100476"},"PeriodicalIF":2.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145011263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acceptability and Barriers of Exercise in Children With Osteogenesis Imperfecta","authors":"Misha Gilani MBChB ,&nbsp;Stacey Todd BSc ,&nbsp;Sze Choong Wong MD ,&nbsp;Helen McDevitt MD ,&nbsp;Andreas Kyriakou MD ,&nbsp;Avril Mason MBChB","doi":"10.1016/j.arrct.2025.100458","DOIUrl":"10.1016/j.arrct.2025.100458","url":null,"abstract":"<div><h3>Objective</h3><div>To define barriers to participation in exercise in pediatric osteogenesis imperfecta (OI) and to gauge the acceptance of an exercise intervention in pediatric OI.</div></div><div><h3>Design</h3><div>A quality improvement study involving the distribution of a custom-made questionnaire assessing exercise habits, perceived barriers to exercise, and acceptability of an exercise intervention as a potential treatment for improvement of muscle-bone outcomes.</div></div><div><h3>Setting</h3><div>Performed at a tertiary pediatric center in Scotland.</div></div><div><h3>Participants</h3><div>Seventeen children (N=17) with OI attending the pediatric bone service between June and September 2019 were included in the study. Because of the Coronavirus disease of 2019 (COVID-19) pandemic, this could not be continued further. No children were excluded. The median age of the population was 12.5 years (range, 3.6-17.7).</div></div><div><h3>Interventions</h3><div>Not applicable.</div></div><div><h3>Main Outcome Measures</h3><div>To gauge the acceptability of an exercise intervention in children with OI by assessing exercise behaviors and attitudes.</div></div><div><h3>Results</h3><div>Out of the respondents, 11 of 17 were fully ambulant, 1 of 17 was ambulant with an aid, 3 of 17 were occasional wheelchair users, and 2 of 17 were full-time wheelchair users. Mostly, 16 of 17, were receiving bisphosphonate therapy, either orally or intravenously, while 5 of 17 used pain-relieving medication at least weekly. Additionally, 16 of 17 reported that having OI made exercise participation more challenging because of joint pain (69%), muscle weakness (50%), tiredness/fatigue (75%), and concern about fractures (75%). All children surveyed participated in sports outside of school, at least once a week, and 15 of 17 stated they would participate in at least 1 additional 30 minutes of exercise per week, with swimming being the most common (71%).</div></div><div><h3>Conclusions</h3><div>Despite barriers to participation in exercise in OI, most children surveyed would wish to participate in an exercise intervention to improve muscle-bone.</div></div>","PeriodicalId":72291,"journal":{"name":"Archives of rehabilitation research and clinical translation","volume":"7 3","pages":"Article 100458"},"PeriodicalIF":2.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145011275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carnitine Deficiency in Rehabilitation Ward Individuals and its Association With Activities of Daily Living: A Pilot Retrospective Observational Study","authors":"Makoto Ueno MD ,&nbsp;Kentaro Kawamura MD, PhD ,&nbsp;Rintaro Ohama MD, PhD ,&nbsp;Keizo Shigenobu MD ,&nbsp;Tadashi Ogura MD ,&nbsp;Megumi Shimodozono MD, PhD","doi":"10.1016/j.arrct.2025.100493","DOIUrl":"10.1016/j.arrct.2025.100493","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the presence of carnitine deficiency in a rehabilitation ward and the differences in functional independence measure (FIM) motor scores between participants with and without carnitine deficiency.</div></div><div><h3>Design</h3><div>A pilot, single-center, cross-sectional, retrospective observational study.</div></div><div><h3>Setting</h3><div>A rehabilitation ward of a hospital where 34% of the local population is aged ≥65 years.</div></div><div><h3>Participants</h3><div>Hospitalized patients in a rehabilitation ward who underwent a blood test during the 3-month observation period; carnitine was measured in participants (N=141) (mean age, 80.3y; 46 men).</div></div><div><h3>Interventions</h3><div>Not applicable.</div></div><div><h3>Main Outcome Measures</h3><div>The primary outcome was the proportion of participants with carnitine deficiency. The secondary outcome was the FIM motor score at admission. Other outcomes were exploratory.</div></div><div><h3>Results</h3><div>The prevalence of carnitine deficiency was 8.5% (12 of 141 participants); 9 of 116 participants (7.8%) were primarily hospitalized for musculoskeletal diseases, and 3 of 24 (12.5%) had cerebrovascular diseases. Participants with carnitine deficiency had significantly lower FIM motor scores (median, 25.0; interquartile range [IQR], 17.2-36.2) than those without (median, 45.0; IQR, 27.0-65.0]; <em>P</em>=.02). The median difference was estimated to be 18.0 (95% CI, 4.0-33.0).</div></div><div><h3>Conclusions</h3><div>This study revealed the presence of carnitine deficiency in a rehabilitation ward in patients who had suffered from stroke or musculoskeletal disease and suggests a possible association with greater difficulty in performing ADL. Further studies in this area are needed.</div></div>","PeriodicalId":72291,"journal":{"name":"Archives of rehabilitation research and clinical translation","volume":"7 3","pages":"Article 100493"},"PeriodicalIF":2.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145011277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}