Introduction The aim of this research is to determine the efficacy of Enviroglobe and Geomat in enhancing sleep and other related parameters of a person sleeping in an environment surrounded with natural and manmade sources of EMF. Materials and Methods Sixty-six healthy subjects (44 subjects for Enviroglobe and 22 subjects for Geomat), between 18-60 years were enrolled for this interventional study. The study was conducted at the Apollo Hospital, New Delhi, India. Result The comparison of sleep data with and without Enviroglobe in terms of Deep Sleep (78.8 ±53.9) vs (85.3 ±30.5), (p<0.030) was found to be statistically significant. There was a trend towards significance in sleep efficiency score and REM sleep as well. We did not find any statistically significant difference between light sleep and awake time. There was a statistically significant difference between the sleep data with Geomat in terms of Sleep efficiency score (67.4 ±9.7) vs (73.8 ±7.6), p< 0.028 and awake time (61.3 ±15.4) vs (51.0 ±11.5), p<0.021. We did not find any statistically significant difference between REM, deep sleep, and light sleep. Discussion The World Health Organization (WHO) / International Agency for Research on Cancer (IARC) has classified radiofrequency electromagnetic fields as possibly carcinogenic to humans (Group 2B), based on an increased risk for glioma, a malignant type of brain cancer associated with wireless phone use.
{"title":"Efficacy of Enviroglobe and Geomat in Combating the Deleterious Effect of Electromagnetic Fields and Geopathic Stress on Sleep","authors":"","doi":"10.33140/bscr.02.03.14","DOIUrl":"https://doi.org/10.33140/bscr.02.03.14","url":null,"abstract":"Introduction The aim of this research is to determine the efficacy of Enviroglobe and Geomat in enhancing sleep and other related parameters of a person sleeping in an environment surrounded with natural and manmade sources of EMF. Materials and Methods Sixty-six healthy subjects (44 subjects for Enviroglobe and 22 subjects for Geomat), between 18-60 years were enrolled for this interventional study. The study was conducted at the Apollo Hospital, New Delhi, India. Result The comparison of sleep data with and without Enviroglobe in terms of Deep Sleep (78.8 ±53.9) vs (85.3 ±30.5), (p<0.030) was found to be statistically significant. There was a trend towards significance in sleep efficiency score and REM sleep as well. We did not find any statistically significant difference between light sleep and awake time. There was a statistically significant difference between the sleep data with Geomat in terms of Sleep efficiency score (67.4 ±9.7) vs (73.8 ±7.6), p< 0.028 and awake time (61.3 ±15.4) vs (51.0 ±11.5), p<0.021. We did not find any statistically significant difference between REM, deep sleep, and light sleep. Discussion The World Health Organization (WHO) / International Agency for Research on Cancer (IARC) has classified radiofrequency electromagnetic fields as possibly carcinogenic to humans (Group 2B), based on an increased risk for glioma, a malignant type of brain cancer associated with wireless phone use.","PeriodicalId":72393,"journal":{"name":"Biomedical science and clinical research","volume":"97 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135470932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sickle cell anemia is one of the major problem in the society, especially the health-care sector. Millions of people in the world are affected and one of the highest incidence occurred in Nigeria. The situation has been further worsened by the insufficient/ inappropriate genetic counseling and diagnosing procedure for the condition. C-reactive protein is one of the greatest indicators that can prevent patients with sickle cell disease from going into cardiac arrest if its level is determined early. This study aimed at improving knowledge on the significance of C-reactive protein as one of the indicators for a possible cardiac attack on sickle cell patients. 131 persons above 18 years of age were recruited, 95 of which were sicklecelled patients and 36 without sickle-cell used as control. Questionnaires were used to collect demographic information of the participants, while their blood samples were collected into Lithium Heparin bottle (3ml), spunned, and plasma was separated, aliquoted in 2 vials and stored at -80oC. Roche (COBAS 311) was used to analyse for C-reactive protein and data summarized in tables. Mean age was 35.4years ±SD=7.54years which ranges from 19 to 56years for sickle cell subjects, and 36.8years ±SD=9.11years which ranges from 19 to 58years for control. The male to female ratio was approximately 2:1 in control and 2.4:1 in sickle cell subjects. 2(2.1%) sickle cell patients had abnormal C-reactive protein, there is no significant difference in mean C-Reactive protein between Sickle cell patients and non-Sickle cell patients (p=.551) and there is no significant relationship between C-Reactive protein in HBSS and haematological parameters like white blood cell (p=0.622) and platelets (p=0.622). No significant disparity was determined between the sickle cell and non-sickle cell individuals. Hence, further studies are needed to confirm the factor behind the abnormal C-reative protein in the two groups.
{"title":"C-Reactive Protein Levels in Adults With Sickle Cell Disease Visiting the University College Hospital, Ibadan, Nigeria","authors":"","doi":"10.33140/bscr.02.03.13","DOIUrl":"https://doi.org/10.33140/bscr.02.03.13","url":null,"abstract":"Sickle cell anemia is one of the major problem in the society, especially the health-care sector. Millions of people in the world are affected and one of the highest incidence occurred in Nigeria. The situation has been further worsened by the insufficient/ inappropriate genetic counseling and diagnosing procedure for the condition. C-reactive protein is one of the greatest indicators that can prevent patients with sickle cell disease from going into cardiac arrest if its level is determined early. This study aimed at improving knowledge on the significance of C-reactive protein as one of the indicators for a possible cardiac attack on sickle cell patients. 131 persons above 18 years of age were recruited, 95 of which were sicklecelled patients and 36 without sickle-cell used as control. Questionnaires were used to collect demographic information of the participants, while their blood samples were collected into Lithium Heparin bottle (3ml), spunned, and plasma was separated, aliquoted in 2 vials and stored at -80oC. Roche (COBAS 311) was used to analyse for C-reactive protein and data summarized in tables. Mean age was 35.4years ±SD=7.54years which ranges from 19 to 56years for sickle cell subjects, and 36.8years ±SD=9.11years which ranges from 19 to 58years for control. The male to female ratio was approximately 2:1 in control and 2.4:1 in sickle cell subjects. 2(2.1%) sickle cell patients had abnormal C-reactive protein, there is no significant difference in mean C-Reactive protein between Sickle cell patients and non-Sickle cell patients (p=.551) and there is no significant relationship between C-Reactive protein in HBSS and haematological parameters like white blood cell (p=0.622) and platelets (p=0.622). No significant disparity was determined between the sickle cell and non-sickle cell individuals. Hence, further studies are needed to confirm the factor behind the abnormal C-reative protein in the two groups.","PeriodicalId":72393,"journal":{"name":"Biomedical science and clinical research","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136100404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The study was conducted to assess the seasonal variations of water quality in Hatirjheel Lake and Dhanmondi Lake during the period from August, 2019 to January, 2020. The water samples were collected monthly during the monsoon and postmonsoon seasons from five sampling stations of both lakes. Comparative analysis revealed that mean pH was near the standard level in both lakes where DO concentration was much lower in Hatirjheel Lake than Dhanmondi Lake which could be due to the direct dumping of nearby residential and commercial waste, and domestic sewages from the city drainage system as well. The BOD concentration in Hairjheel Lake water exceeded the standard in both seasons and there was no significant change over seasons. In contrast, the Dhanmondi Lake water showed relatively lower BOD concentrations in both seasons where mean concentration slightly exceeded the standard in some stations. The EC and TDS contents showed positive relations but exceeded the standard limit throughout seasons in both lakes. The nutrient contents (NO3 -, NO2 - and NH4 +) of Hatirjheel Lake water highly exceeded the standard during the study that tends the lake water prone to eutrophication. The study revealed that the physicochemical parameters and nutrient status of Dhanmondi Lake water were within the standard limit except EC indicating a rich habitat for aquatic organisms and sounds for recreational activities than Hatirjheel Lake which should be monitored throughout the year to maintain the productivity of lake water systems.
{"title":"Assessment of the Seasonal Variations of Lakes Water Quality in Bangladesh","authors":"","doi":"10.33140/bscr.02.03.12","DOIUrl":"https://doi.org/10.33140/bscr.02.03.12","url":null,"abstract":"The study was conducted to assess the seasonal variations of water quality in Hatirjheel Lake and Dhanmondi Lake during the period from August, 2019 to January, 2020. The water samples were collected monthly during the monsoon and postmonsoon seasons from five sampling stations of both lakes. Comparative analysis revealed that mean pH was near the standard level in both lakes where DO concentration was much lower in Hatirjheel Lake than Dhanmondi Lake which could be due to the direct dumping of nearby residential and commercial waste, and domestic sewages from the city drainage system as well. The BOD concentration in Hairjheel Lake water exceeded the standard in both seasons and there was no significant change over seasons. In contrast, the Dhanmondi Lake water showed relatively lower BOD concentrations in both seasons where mean concentration slightly exceeded the standard in some stations. The EC and TDS contents showed positive relations but exceeded the standard limit throughout seasons in both lakes. The nutrient contents (NO3 -, NO2 - and NH4 +) of Hatirjheel Lake water highly exceeded the standard during the study that tends the lake water prone to eutrophication. The study revealed that the physicochemical parameters and nutrient status of Dhanmondi Lake water were within the standard limit except EC indicating a rich habitat for aquatic organisms and sounds for recreational activities than Hatirjheel Lake which should be monitored throughout the year to maintain the productivity of lake water systems.","PeriodicalId":72393,"journal":{"name":"Biomedical science and clinical research","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135487875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The monumental effect of COVID-19 on medical systems worldwide necessitates a better knowledge of the immune responses associated with SARS-CoV-2 infection in order to develop therapeutic solutions. Although several distinctive features of the disease have been regularly found, we are still in the early stages of closing this knowledge gap. Natural Killer Cells are still a shining light in these difficult times. Up until recently, the majority of NK cell research was devoted to the treatment of cancer. However, because NK cells are non- specific, they might work well against any virus now and in the future. Our article is an attempt to shed light on and draw the scientific community's attention to the fact that it has become crucial to look into the specific mechanisms underlying NK cell function in order to better understand infections like SARS-CoV-2 and develop cutting-edge immunotherapy in the future.
{"title":"Natural Killer Cells: Flare Amidst the Grim","authors":"","doi":"10.33140/bscr.02.03.11","DOIUrl":"https://doi.org/10.33140/bscr.02.03.11","url":null,"abstract":"The monumental effect of COVID-19 on medical systems worldwide necessitates a better knowledge of the immune responses associated with SARS-CoV-2 infection in order to develop therapeutic solutions. Although several distinctive features of the disease have been regularly found, we are still in the early stages of closing this knowledge gap. Natural Killer Cells are still a shining light in these difficult times. Up until recently, the majority of NK cell research was devoted to the treatment of cancer. However, because NK cells are non- specific, they might work well against any virus now and in the future. Our article is an attempt to shed light on and draw the scientific community's attention to the fact that it has become crucial to look into the specific mechanisms underlying NK cell function in order to better understand infections like SARS-CoV-2 and develop cutting-edge immunotherapy in the future.","PeriodicalId":72393,"journal":{"name":"Biomedical science and clinical research","volume":"59 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135488290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Purpose: The aim of this in-vivo study was to evaluate the skeletal changes of a modified Twin Block with clear plates versus a conventional Twin Block appliance in skeletal class II patients. Methods and Materials: A total of 32 patients with skeletal class II malocclusion contributing to mandibular retrognathism were involved. The sample was divided into two groups: group A: 16 patients will undergo to orthodontic treatment with modified Twin Block with clear plates; group B: 16 patients will undergo to orthodontic treatment with conventional Twin Block appliance. After 12 months of treatment a cephalometric radiograph was taken in central occlusion to study skeletal changes. Independent sample T-test was used for studying significance between groups. Results: There were significant differences in MP-SN; MP-SPP and SN-NPG values. While there were no statistically significant differences in SNA, SNB and ANB values. A significant difference was observed after 12 months of treatment for each group (P<0.05). Conclusion: Modified Twin Block with clear plates is an effective alternative device to treat skeletal class II malocclusion with vertical growth pattern.
{"title":"Skeletal Effect of Modified Twin Block with Clear Plates Versus Conventional Twin Block in Class II Malocclusions – a Randomized Controlled Trial of Functional Appliances","authors":"","doi":"10.33140/bscr.02.03.10","DOIUrl":"https://doi.org/10.33140/bscr.02.03.10","url":null,"abstract":"Purpose: The aim of this in-vivo study was to evaluate the skeletal changes of a modified Twin Block with clear plates versus a conventional Twin Block appliance in skeletal class II patients. Methods and Materials: A total of 32 patients with skeletal class II malocclusion contributing to mandibular retrognathism were involved. The sample was divided into two groups: group A: 16 patients will undergo to orthodontic treatment with modified Twin Block with clear plates; group B: 16 patients will undergo to orthodontic treatment with conventional Twin Block appliance. After 12 months of treatment a cephalometric radiograph was taken in central occlusion to study skeletal changes. Independent sample T-test was used for studying significance between groups. Results: There were significant differences in MP-SN; MP-SPP and SN-NPG values. While there were no statistically significant differences in SNA, SNB and ANB values. A significant difference was observed after 12 months of treatment for each group (P<0.05). Conclusion: Modified Twin Block with clear plates is an effective alternative device to treat skeletal class II malocclusion with vertical growth pattern.","PeriodicalId":72393,"journal":{"name":"Biomedical science and clinical research","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136264318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: posts that have been properly fitted can withstand torsion and provide better retention. The purpose of this study was to evaluate the push-out bond strength of glass fiber posts cemented with different luting agents. The push-out bonding strength of glass fiber posts to the root canal was evaluated using resin-modified glass ionomer cement (RMGIC) and flowable composite (FC). Materials and Methods: Thirty single-rooted extracted human mandibular premolars were sectioned 2 mm coronal to the most incisal point of the cementoenamel junction. Root canals were instrumented and obturated with laterally condensed gutta-percha and root canal sealer (ADSEAL). Gutta-percha was removed from the canals to a depth of 11 mm and diameter post spaces with a 1.5 mm were prepared. The specimens were divided into the following 3 groups according to the luting agent used (n=10). The first group utilized FC (HARVARD, Germany) to coat the post, whereas the second group used RMGIC (Meron plus QM, VOCO, Germany). whereas the third group used Resin Cement (ITENA clinical, France) was used as the control. The specimens were cross-sectioned after 24 h. Specimens were cross-sectioned six millimeters thick into coronal using a sectioning machine. The strength of the bond between the luting cement and the posts was measured using push-out bond strength testing. We loaded the components at a cross speed of 0.5 mm/min on a universal testing machine until the bond failed. Results: The FC group had a 73.53N push-out bond strength, whereas the RMGIC group had a 133.55N, whereas the Resin Cement group had a 137.47N push-out bond strength. Conclusion: FC’s mean push-out bond strength score is lower than RMGIC’s and Resin Cement.
{"title":"Comparative Study of Bond Strength of Resin-Modified Glass Ionomer Cement and Flowable Composite with Glass Fiber Posts by Push-Out Test","authors":"","doi":"10.33140/bscr.02.03.09","DOIUrl":"https://doi.org/10.33140/bscr.02.03.09","url":null,"abstract":"Introduction: posts that have been properly fitted can withstand torsion and provide better retention. The purpose of this study was to evaluate the push-out bond strength of glass fiber posts cemented with different luting agents. The push-out bonding strength of glass fiber posts to the root canal was evaluated using resin-modified glass ionomer cement (RMGIC) and flowable composite (FC). Materials and Methods: Thirty single-rooted extracted human mandibular premolars were sectioned 2 mm coronal to the most incisal point of the cementoenamel junction. Root canals were instrumented and obturated with laterally condensed gutta-percha and root canal sealer (ADSEAL). Gutta-percha was removed from the canals to a depth of 11 mm and diameter post spaces with a 1.5 mm were prepared. The specimens were divided into the following 3 groups according to the luting agent used (n=10). The first group utilized FC (HARVARD, Germany) to coat the post, whereas the second group used RMGIC (Meron plus QM, VOCO, Germany). whereas the third group used Resin Cement (ITENA clinical, France) was used as the control. The specimens were cross-sectioned after 24 h. Specimens were cross-sectioned six millimeters thick into coronal using a sectioning machine. The strength of the bond between the luting cement and the posts was measured using push-out bond strength testing. We loaded the components at a cross speed of 0.5 mm/min on a universal testing machine until the bond failed. Results: The FC group had a 73.53N push-out bond strength, whereas the RMGIC group had a 133.55N, whereas the Resin Cement group had a 137.47N push-out bond strength. Conclusion: FC’s mean push-out bond strength score is lower than RMGIC’s and Resin Cement.","PeriodicalId":72393,"journal":{"name":"Biomedical science and clinical research","volume":"48 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135205417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction Orthodontic debonding procedures usually involve pain and discomfort. The purpose of this in vivo study was to evaluate the effectiveness of laser and ultrasound on pain management during orthodontic debonding along with its effect on the enamel surface. Materials and Methods 42 patients referred for orthodontic treatment at the Department of Orthodontics, University of Hama, were recruited. After finishing treatment, a randomized debonding was accomplished with one of three methods: group 1 (control group): bracket removing plier (KP-013-135-PMK ,CHIFA ,Germany); group 2: Er:YAG laser (Pluser, Doctor Smile, Italy); group 3: ultrasonic scalar (Woodpecker, UDS-J ,China) (n=14). The pain intensity was evaluated using numeric rating scale (NRS), and the amount of adhesive remnant was determined by The Adhesive Remnant Index (ARI). Data were subjected to analysis of variance (ANOVA) and Bonferroni test. Results The highest NRS values was observed with group 1 (3.86 ± 1.46), whereas the lowest values were recorded with group 2 (1.64 ± 1.15). Debonding brackets using Er:YAG laser produced significant lower pain intensity compared to plier and ultrasonic scalar (P < 0.05). The ARI values recorded for group 1 were significantly higher than those of two other groups (p<0.05), while there were no statistically significant differences between group 2 and group 3. Conclusion Debonding orthodontic bracket with Er: YAG laser reduce the pain intensity and discomfort. Additionally, Er: YAG laser appears as an alternative method to reduce the adhesive remnants were left on the tooth surface
正畸脱粘手术通常伴随着疼痛和不适。本体内研究的目的是评估激光和超声对正畸脱粘过程中疼痛管理的有效性及其对牙釉质表面的影响。材料与方法选取哈马大学正畸科转介正畸治疗的患者42例。治疗结束后，采用三种方法中的一种进行随机脱粘:第一组(对照组):托钳(KP-013-135-PMK,CHIFA，德国);第二组:Er:YAG激光(Pluser, Doctor Smile，意大利);第三组:超声标量(Woodpecker, ads - j,China) (n=14)。采用数值评定量表(NRS)评估疼痛强度，采用The adhesive remnant Index (ARI)评估粘附物残留量。数据进行方差分析(ANOVA)和Bonferroni检验。结果组1 NRS值最高(3.86±1.46)，组2 NRS值最低(1.64±1.15)。与钳子和超声标量(P <0.05)。1组患者ARI值显著高于其他两组(p < 0.05)， 2组与3组比较差异无统计学意义。结论Er: YAG激光脱粘正畸托架可减轻疼痛强度和不适。此外，Er: YAG激光作为一种替代方法出现，以减少牙表面残留的粘合剂
{"title":"Impact of Laser and Ultrasound on Pain Intensity and Enamel Surface During Orthodontic Debonding (A Randomized Clinical Trial)","authors":"","doi":"10.33140/bscr.02.03.08","DOIUrl":"https://doi.org/10.33140/bscr.02.03.08","url":null,"abstract":"Introduction Orthodontic debonding procedures usually involve pain and discomfort. The purpose of this in vivo study was to evaluate the effectiveness of laser and ultrasound on pain management during orthodontic debonding along with its effect on the enamel surface. Materials and Methods 42 patients referred for orthodontic treatment at the Department of Orthodontics, University of Hama, were recruited. After finishing treatment, a randomized debonding was accomplished with one of three methods: group 1 (control group): bracket removing plier (KP-013-135-PMK ,CHIFA ,Germany); group 2: Er:YAG laser (Pluser, Doctor Smile, Italy); group 3: ultrasonic scalar (Woodpecker, UDS-J ,China) (n=14). The pain intensity was evaluated using numeric rating scale (NRS), and the amount of adhesive remnant was determined by The Adhesive Remnant Index (ARI). Data were subjected to analysis of variance (ANOVA) and Bonferroni test. Results The highest NRS values was observed with group 1 (3.86 ± 1.46), whereas the lowest values were recorded with group 2 (1.64 ± 1.15). Debonding brackets using Er:YAG laser produced significant lower pain intensity compared to plier and ultrasonic scalar (P < 0.05). The ARI values recorded for group 1 were significantly higher than those of two other groups (p<0.05), while there were no statistically significant differences between group 2 and group 3. Conclusion Debonding orthodontic bracket with Er: YAG laser reduce the pain intensity and discomfort. Additionally, Er: YAG laser appears as an alternative method to reduce the adhesive remnants were left on the tooth surface","PeriodicalId":72393,"journal":{"name":"Biomedical science and clinical research","volume":"64 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136338290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Hepatoblastoma is the most common malignant liver tumor in children. Treatment protocols varies. In our center, we have adopted the Children’s Oncology Group (COG) AHEP0731 protocol, in addition to some experimental regimens for relapsed solid tumors. Methods: We aimed to investigate the outcome of the current hepatoblastoma treatment protocol at our center. 15 patients were included between January 2008 and June 2023. A retrospective review was carried to review the clinical presentation, serum α-fetoprotein (AFP) level at diagnosis, histological subtype, treatment, and outcomes. Results: 12 patients (80%) were symptomatic at time of diagnosis, with abdominal mass being the most common presenting complaint. Nine patients (60%) presented in stage 3 PRETEXT staging system. Epithelial histopathological subtype was predominant subtype. Thirteen patients have received preoperative chemotherapy, followed by surgical resection; only one patient underwent upfront surgical resection followed by chemotherapy. Preoperative chemotherapy consists of 2 to 4 cycles of Cisplatin, Fluorouracil, Vincristine and Doxorubicin (C5VD), followed by surgical resection. Four of them underwent neoadjuvent experimental chemotherapy utilizing agents such as Pazopanib, Pembrolizumab and Sorafenib. During followup, six patients died of progressive disease. The median survival time was 42 months (95% confidence interval: 18–42%). Five-year overall survival was 44.09% (95% confidence interval: 18–42%). Conclusions: The combination of surgery and chemotherapy for hepatoblastoma is an effective approach. Utilization of new-targeted therapies and relapsed solid tumors regimens may prolong life in patients who did not respond to standard therapy. Further studies are required to validate its usage on patients with advanced hepatoblastoma.
{"title":"Treatment Outcomes for Hepatoblastoma: 15-Years-Experience of a Single Institution – Sheikh Khalifa Medical City, Abu Dhabi, UAE","authors":"","doi":"10.33140/bscr.02.03.07","DOIUrl":"https://doi.org/10.33140/bscr.02.03.07","url":null,"abstract":"Background: Hepatoblastoma is the most common malignant liver tumor in children. Treatment protocols varies. In our center, we have adopted the Children’s Oncology Group (COG) AHEP0731 protocol, in addition to some experimental regimens for relapsed solid tumors. Methods: We aimed to investigate the outcome of the current hepatoblastoma treatment protocol at our center. 15 patients were included between January 2008 and June 2023. A retrospective review was carried to review the clinical presentation, serum α-fetoprotein (AFP) level at diagnosis, histological subtype, treatment, and outcomes. Results: 12 patients (80%) were symptomatic at time of diagnosis, with abdominal mass being the most common presenting complaint. Nine patients (60%) presented in stage 3 PRETEXT staging system. Epithelial histopathological subtype was predominant subtype. Thirteen patients have received preoperative chemotherapy, followed by surgical resection; only one patient underwent upfront surgical resection followed by chemotherapy. Preoperative chemotherapy consists of 2 to 4 cycles of Cisplatin, Fluorouracil, Vincristine and Doxorubicin (C5VD), followed by surgical resection. Four of them underwent neoadjuvent experimental chemotherapy utilizing agents such as Pazopanib, Pembrolizumab and Sorafenib. During followup, six patients died of progressive disease. The median survival time was 42 months (95% confidence interval: 18–42%). Five-year overall survival was 44.09% (95% confidence interval: 18–42%). Conclusions: The combination of surgery and chemotherapy for hepatoblastoma is an effective approach. Utilization of new-targeted therapies and relapsed solid tumors regimens may prolong life in patients who did not respond to standard therapy. Further studies are required to validate its usage on patients with advanced hepatoblastoma.","PeriodicalId":72393,"journal":{"name":"Biomedical science and clinical research","volume":"51 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135746828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background Overgrowth after femoral diaphyseal fractures in children has been well-known. The process and degree of overgrowth vary among patients, making it difficult to predict the length of the fractured femur at growth arrest. Materials and Methods 3 cases aged 4-7 years (2 boys and 1 girl) with femoral diaphyseal fractures were subjected. Observation period was 6-12 years. Leg length was assessed by taking a simple X-ray of the entire lower extremities in a standing position. Results 2 cases underwent anatomical reduction and external fixation. After the fracture had healed, there was overgrowth of the fractured femur, resulting in leg length discrepancy. Both cases were treated with an 8-plate temporal epiphysiodesis. 1 case was treated conservatively with skeletal traction, and fracture was healed with overriding of bone fragments. Overgrowth occurred and resulted in a fractured femur that became longer than opposite side. However, leg length discrepancy was gradually self-corrected and was eventually eliminated. Conclusions Overgrowth after femoral diaphyseal fracture was seen in all patients. Overgrowth tended to occur rapidly after the fracture and then slow down. Leg length discrepancy caused by overgrowth may be corrected during growth to some degree, and it should be decided whether patient need additional treatment.
{"title":"Bone Growth After Fracture of the Femoral Shaft in Children","authors":"","doi":"10.33140/bscr.02.03.06","DOIUrl":"https://doi.org/10.33140/bscr.02.03.06","url":null,"abstract":"Background Overgrowth after femoral diaphyseal fractures in children has been well-known. The process and degree of overgrowth vary among patients, making it difficult to predict the length of the fractured femur at growth arrest. Materials and Methods 3 cases aged 4-7 years (2 boys and 1 girl) with femoral diaphyseal fractures were subjected. Observation period was 6-12 years. Leg length was assessed by taking a simple X-ray of the entire lower extremities in a standing position. Results 2 cases underwent anatomical reduction and external fixation. After the fracture had healed, there was overgrowth of the fractured femur, resulting in leg length discrepancy. Both cases were treated with an 8-plate temporal epiphysiodesis. 1 case was treated conservatively with skeletal traction, and fracture was healed with overriding of bone fragments. Overgrowth occurred and resulted in a fractured femur that became longer than opposite side. However, leg length discrepancy was gradually self-corrected and was eventually eliminated. Conclusions Overgrowth after femoral diaphyseal fracture was seen in all patients. Overgrowth tended to occur rapidly after the fracture and then slow down. Leg length discrepancy caused by overgrowth may be corrected during growth to some degree, and it should be decided whether patient need additional treatment.","PeriodicalId":72393,"journal":{"name":"Biomedical science and clinical research","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136383374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anesthetics, antibiotics, magnetic resonance imaging scanners, and radiation have all benefited from technological advancements. Even while developments in healthcare are being driven by new technology (drugs, gadgets, social media support for healthcare, etc.), human concerns will continue to be a barrier to any advances that are made. The field of medicine will continue to be disrupted by technological advances. The purpose of this mini review article is to help us think more clearly about how we want to go and gratify as many people as possible by highlighting the need for new developments in healthcare technology, its multiple uses, and fragments of the future.
{"title":"Navigating the Future of Healthcare: A Review of Emerging Technology Implementation","authors":"","doi":"10.33140/bscr.02.03.05","DOIUrl":"https://doi.org/10.33140/bscr.02.03.05","url":null,"abstract":"Anesthetics, antibiotics, magnetic resonance imaging scanners, and radiation have all benefited from technological advancements. Even while developments in healthcare are being driven by new technology (drugs, gadgets, social media support for healthcare, etc.), human concerns will continue to be a barrier to any advances that are made. The field of medicine will continue to be disrupted by technological advances. The purpose of this mini review article is to help us think more clearly about how we want to go and gratify as many people as possible by highlighting the need for new developments in healthcare technology, its multiple uses, and fragments of the future.","PeriodicalId":72393,"journal":{"name":"Biomedical science and clinical research","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135066154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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