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Evaluation of a 12-week app-guided exercise intervention in patients with knee osteoarthritis (re.flex): a study protocol for a randomized controlled trial 评估一项为期12周的应用程序引导的运动干预膝关节骨关节炎患者(反射):一项随机对照试验的研究方案
Pub Date : 2023-10-05 DOI: 10.1186/s44247-023-00040-1
Valerie Dieter, Peter Martus, Pia Janssen, Inga Krauss
Abstract Background Current health care demonstrates an insufficient provision and utilization of physical exercises despite their recommendation as a first-line treatment in clinical guidelines for patients with knee osteoarthritis (OA). Mobile health (m-health) technologies offer new opportunities to guide and monitor home-based exercise programs by using mobile devices and inertial sensors in combination with a digital application (app). This study will evaluate patient benefits resulting from the use of the specific digital health application re.flex for patients with knee OA. Methods This monocentric, two-arm, randomized controlled parallel-group trial will evaluate the effectiveness of the app- and sensor-guided exercise program re.flex for patients with moderate-to-severe knee OA. We aim to recruit 200 participants via newspapers, newsletters and information events. Participants will be randomly allocated to the intervention group and the control group in a 1:1 ratio. Participants in the control group will not receive any study intervention or instruction for any change to their previous health care utilization. Despite this, they are allowed to make use of usual care provided by their treating physician. The intervention group comprises a 12-week home training program with three sessions per week in addition to usual care. Exercises will be guided and monitored by use of the training app (re.flex) and two accelerometers that are attached proximally and distally to the affected knee joint. Pre- and postmeasurements will take place at baseline (t0) and after 12 weeks (t1). Primary outcomes will be osteoarthritis-specific pain and physical function measured with the Knee Osteoarthritis Outcome Score (KOOS) subscales Pain and Function in daily living (ADL). Second, further self-reported health outcomes, a performance measurement, app logfiles and safety will be assessed. Intervention effects will be calculated by baseline-adjusted analysis of covariance (ANCOVA) using an intention-to-treat approach. Multiple imputation will be applied. Discussion Re.flex can bridge part of the gap between recommendations for strengthening exercises in patients with knee OA and the insufficient actual care situation. This randomized controlled trial is designed to provide conclusions on the effectiveness of the health application re.flex for the population under study and will provide further insight into adherence rates and the safety of its use. Trial registration The trial was registered on 20/01/2023 at www.drks.de (ID: DRKS00030932).
摘要背景:目前的医疗保健表明,尽管体育锻炼被推荐为膝关节骨关节炎(OA)患者的一线治疗方法,但体育锻炼的提供和利用不足。移动保健技术提供了新的机会,通过使用移动设备和惯性传感器与数字应用程序(app)相结合,指导和监测家庭锻炼计划。本研究将评估使用特定数字健康应用程序refo .flex对膝关节OA患者的益处。方法本单中心、双臂、随机对照平行组试验将评估应用程序和传感器引导的运动程序反射弯曲对中重度膝关节OA患者的有效性。我们的目标是通过报纸、通讯和信息活动招募200名参与者。参与者将按1:1的比例随机分配到干预组和对照组。对照组的参与者将不接受任何研究干预或指导,以改变他们以前的医疗保健利用。尽管如此,他们仍被允许利用主治医生提供的常规护理。干预组包括一个为期12周的家庭培训计划,除了常规护理外,每周有三次培训。训练将通过训练应用程序(refi .flex)和连接在受影响膝关节的近端和远端两个加速度计来指导和监测。术前和术后测量分别在基线(t1)和12周后(t1)进行。主要结局将是骨关节炎特异性疼痛和身体功能,用膝关节骨关节炎结局评分(oos)亚量表测量疼痛和日常生活功能(ADL)。其次,进一步的自我报告的健康结果,性能测量,应用程序日志文件和安全性将被评估。干预效果将通过使用意向治疗方法的基线调整协方差分析(ANCOVA)来计算。将应用多重输入。rever .flex可以弥补膝关节OA患者建议加强锻炼与实际护理不足之间的部分差距。这项随机对照试验旨在为研究人群提供有关健康应用程序refo .flex有效性的结论,并将进一步了解其使用的依从率和安全性。该试验于2023年1月20日在www.drks.de注册(ID: DRKS00030932)。
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引用次数: 0
Validation of the six-minute walking distance measured by FeetMe® insoles 验证由FeetMe®鞋垫测量的6分钟步行距离
Pub Date : 2023-10-03 DOI: 10.1186/s44247-023-00038-9
Andrey Mostovov, Damien Jacobs, Leila Farid, Paul Dhellin, Guillaume Baille
Abstract Background The six-minute walk test (6MWT) is widely used to assess functional capacity in patients with various diseases. Use of wearable devices can make this test more accurate and easier to administer, and may even enhance it by providing additional information. The purpose of this study was to evaluate the validity of FeetMe® insoles for assessing the total six-minute walking distance (6MWD) by comparing the FeetMe® estimates and those obtained by a rater to the ground truth measured with a surveyor’s wheel. Results Data were analyzed from healthy volunteers who performed the 6MWT on 10-m and 30-m tracks while wearing FeetMe® insoles ( n = 32), and being simultaneously assessed by a rater ( n = 33) and followed by an investigator with a surveyor’s wheel. The mean average error (MAE) of the estimates was below 13 m on both tracks for FeetMe®, whereas it ranged from 16.24 m to 38.88 m on the 30-m and 10-m tracks for the rater. Conclusion The FeetMe® insoles provided a more accurate estimate and showed greater agreement with the ground truth than the rater, and the accuracy of the FeetMe® estimates did not vary according to the track length. We conclude that the FeetMe insoles are a valid solution for measuring the 6MWD.
摘要背景6分钟步行试验(6MWT)被广泛用于评估各种疾病患者的功能能力。使用可穿戴设备可以使这项测试更准确,更容易管理,甚至可以通过提供额外的信息来增强它。本研究的目的是通过比较FeetMe®估计值和评估者获得的估计值与测量轮测量的地面真实值,来评估FeetMe®鞋垫评估总6分钟步行距离(6MWD)的有效性。结果分析了健康志愿者的数据,这些志愿者穿着FeetMe®鞋垫在10米和30米的轨道上进行6MWT (n = 32),同时由评估师(n = 33)进行评估,并由带测量轮的调查员进行跟踪。FeetMe®在两条轨道上的平均误差(MAE)均低于13 m,而在30米和10米轨道上的平均误差在16.24 m至38.88 m之间。结论:与rater相比,FeetMe®鞋垫提供了更准确的估计,与地面事实更一致,并且FeetMe®估计的准确性不随轨道长度而变化。我们得出结论,FeetMe鞋垫是测量6MWD的有效解决方案。
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引用次数: 1
Description of patient characteristics and medication adherence among medication access mobile application users and nonusers: a single-center questionnaire-based cross-sectional study 在药物访问移动应用程序用户和非用户中描述患者特征和药物依从性:一项基于单中心问卷的横断面研究
Pub Date : 2023-10-02 DOI: 10.1186/s44247-023-00039-8
Ghadah Assiri, Dalal Alabdulkarim, Asrar Alanazi, Sarah Altamimi, Nadin Lafi Alanazi, Wael Khawagi
Abstract Background In this study, we aimed to describe patient characteristics and medication adherence among medication access mobile application users and nonusers. Methods This was a cross-sectional study of a randomly selected sample of patients who refilled their medications either through the mobile application ‘MNG-HA Care’ or by phone call to a government-funded multispecialty hospital in Riyadh, Saudi Arabia. Data were collected through an online survey and filed either via WhatsApp or by phone call. Medication adherence was assessed using the five-item Medication Adherence Report Scale (MARS-5). Results A total of 280 respondents were recruited, and their mean age was 48.8 years (standard deviation (SD): 17.8). More than 75% of application users and nonusers were younger (18–64 years) and lived in urban areas, 58% were male, 37.5% held a bachelor’s degree, and 40% were unemployed. The number of respondents who accessed the mobile application (mobile application users) was 212, and 64.2% of them were adherent to their medications. Sixty-eight of the respondents used a phone call for refills (mobile application nonusers), and 77.9% of them were adherent to their medications. The most common self-reported reasons for using the application were to book an appointment and to request a medication refill. The most common self-reported reasons for not using the application were respondents’ lack of knowledge about the availability of the application and preference for speaking directly to the health care provider. Adjusted multivariate logistic regression analysis revealed that medication adherence was not associated with application use (Odds Ratio (OR): 0.65; 95% CI: 0.33–1.29). However, male patients had significantly higher adherence than females (OR 2.68, 95% CI 1.31 to 5.51), and employed patients had significantly lower adherence than unemployed patients (OR 0.37, 95% CI 0.17 to 0.81). Conclusions Providing patients with access to their medication list through a mobile application alone did not significantly impact medication adherence. Further research is needed to explore the potential benefits of incorporating additional features, such as medication instructions and reminders within mobile applications, to improve medication adherence.
摘要背景在本研究中,我们旨在描述药物获取移动应用程序用户和非用户的患者特征和药物依从性。这是一项横断面研究,随机选择患者样本,通过移动应用程序“MNG-HA Care”或通过电话向沙特阿拉伯利雅得政府资助的多专科医院补充药物。数据通过在线调查收集,并通过WhatsApp或电话提交。用药依从性采用5项用药依从性报告量表(MARS-5)进行评估。结果共纳入调查对象280人,平均年龄48.8岁(标准差:17.8)。超过75%的应用程序用户和非用户是年轻人(18-64岁),居住在城市地区,58%是男性,37.5%拥有学士学位,40%失业。访问移动应用程序(移动应用程序用户)的受访者人数为212人,其中64.2%的人坚持服药。68名受访者使用电话补药(不使用移动应用程序),77.9%的人坚持服药。使用该应用程序的最常见的自我报告原因是预约和请求药物补充。自我报告的不使用该应用程序的最常见原因是受访者对该应用程序的可用性缺乏了解,并且倾向于直接与卫生保健提供者交谈。调整后的多因素logistic回归分析显示,药物依从性与应用程序使用无关(优势比(OR): 0.65;95% ci: 0.33-1.29)。然而,男性患者的依从性明显高于女性(OR 2.68, 95% CI 1.31至5.51),就职患者的依从性明显低于未就职患者(OR 0.37, 95% CI 0.17至0.81)。结论仅通过移动应用程序向患者提供药物清单对药物依从性没有显著影响。需要进一步的研究来探索在移动应用程序中加入额外功能的潜在好处,例如药物说明和提醒,以提高药物依从性。
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引用次数: 0
Tuuned in: use of an online contraceptive decision aid for women increases reproductive self-efficacy and knowledge; results of an experimental clinical trial 调整:使用在线避孕决策帮助妇女提高生殖自我效能和知识;实验性临床试验的结果
Pub Date : 2023-09-18 DOI: 10.1186/s44247-023-00034-z
Summer Mengelkoch, Matthew Espinosa, Stephen A. Butler, Laura Joigneau Prieto, Emma Russell, Chris Ramshaw, Shardi Nahavandi, Sarah E. Hill
Abstract Background Digital decision aids are becoming increasingly common in many areas of healthcare. These aids are designed to involve patients in medical decision making, with the aim of improving patient outcomes while decreasing healthcare burden. Previously developed contraceptive-based decision aids have been found to be effective at increasing women’s knowledge about reproductive health and contraception. Here, we sought to evaluate the effectiveness of a novel contraceptive-based decision aid at increasing women’s self-efficacy and knowledge about their reproductive health and contraceptive options, as well as their perceptions of their learning. This study was registered as a clinic trial at ClinicalTrials.gov (Contraception Decision Aid Use and Patient Outcomes, ID# NCT05177783) on 05/01/2022. Methods The Tuune® contraceptive decision aid’s effectiveness was evaluated by conducting an experiment in which 324 women were assigned to use the Tuune® decision aid or a control decision aid. Primary outcomes included reproductive health self-efficacy, reproductive health and contraceptive knowledge, and perceptions of learning. Secondary analyses examined whether prior experience using hormonal contraceptives moderated the relationship between decision aid and each outcome measure. Results Women assigned to use the Tuune® decision aid exhibited greater reproductive health self-efficacy, greater knowledge about reproductive health and contraception, and perceived having learned more than women assigned to use the control decision aid ( p s ≤ .029). This pattern was also observed in women with previous contraceptive use experience, where women using Tuune® reported better outcomes than women using the control aid, regardless of their history of hormonal contraceptive use experience, although this interaction was not significant ( p = .089). Conclusions Use of the Tuune® contraceptive-based decision aid improved each of the predicted outcomes relative to a control decision aid. This suggests that use of the Tuune® contraceptive-based decision aid is well poised to increase women’s confidence and knowledge about contraceptive use and may also reduce burden on healthcare systems.
数字辅助决策在医疗保健的许多领域正变得越来越普遍。这些辅助工具旨在让患者参与医疗决策,目的是改善患者的治疗效果,同时减轻医疗负担。人们发现,以前开发的以避孕药具为基础的决策辅助工具在提高妇女对生殖健康和避孕的知识方面很有效。在这里,我们试图评估一种新型的基于避孕药的决策辅助在提高妇女的自我效能感和对其生殖健康和避孕选择的认识以及她们对自己学习的看法方面的有效性。该研究已于2022年5月1日在ClinicalTrials.gov注册为临床试验(避孕决策辅助使用和患者结局,ID# NCT05177783)。方法通过对324名妇女进行tunune®避孕辅助决策器和对照组决策器的试验,评价tunune®避孕辅助决策器的有效性。主要结果包括生殖健康自我效能、生殖健康和避孕知识以及学习感知。二次分析检验了先前使用激素避孕药的经验是否调节了决策辅助和每个结果测量之间的关系。结果使用Tuune®决策辅助工具的妇女表现出更高的生殖健康自我效能感,对生殖健康和避孕有更多的了解,并认为比使用对照组决策辅助工具的妇女学到了更多(p s≤0.029)。在既往使用过避孕药具的妇女中也观察到这种模式,使用Tuune®的妇女报告的结果优于使用对照药物的妇女,无论她们的激素避孕药使用史如何,尽管这种相互作用并不显著(p = 0.089)。结论:使用tune®基于避孕药的辅助决策改善了每一个预测结果相对于控制决策援助。这表明,使用Tuune®基于避孕药的决策辅助工具可以很好地提高妇女对避孕药具使用的信心和知识,也可以减轻卫生保健系统的负担。
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引用次数: 0
Correction: Machine learning-based prediction of COVID-19 mortality using immunological and metabolic biomarkers 更正:使用免疫和代谢生物标志物基于机器学习的COVID-19死亡率预测
Pub Date : 2023-09-12 DOI: 10.1186/s44247-023-00045-w
Thomas Wetere Tulu, Tsz Kin Wan, Ching Long Chan, Chun Hei Wu, Peter Yat Ming Woo, Cee Zhung Steven Tseng, Asmir Vodencarevic, Cristina Menni, Kei Hang Katie Chan
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引用次数: 0
Discovering social determinants of health from case reports using natural language processing: algorithmic development and validation 使用自然语言处理从病例报告中发现健康的社会决定因素:算法开发和验证
Pub Date : 2023-09-11 DOI: 10.1186/s44247-023-00035-y
Shaina Raza, Elham Dolatabadi, Nancy Ondrusek, Laura Rosella, Brian Schwartz
Abstract Background Social determinants of health are non-medical factors that influence health outcomes (SDOH). There is a wealth of SDOH information available in electronic health records, clinical reports, and social media data, usually in free text format. Extracting key information from free text poses a significant challenge and necessitates the use of natural language processing (NLP) techniques to extract key information. Objective The objective of this research is to advance the automatic extraction of SDOH from clinical texts. Setting and data The case reports of COVID-19 patients from the published literature are curated to create a corpus. A portion of the data is annotated by experts to create ground truth labels, and semi-supervised learning method is used for corpus re-annotation. Methods An NLP framework is developed and tested to extract SDOH from the free texts. A two-way evaluation method is used to assess the quantity and quality of the methods. Results The proposed NER implementation achieves an accuracy (F1-score) of 92.98% on our test set and generalizes well on benchmark data. A careful analysis of case examples demonstrates the superiority of the proposed approach in correctly classifying the named entities. Conclusions NLP can be used to extract key information, such as SDOH factors from free texts. A more accurate understanding of SDOH is needed to further improve healthcare outcomes.
健康的社会决定因素是影响健康结果(SDOH)的非医学因素。电子健康记录、临床报告和社交媒体数据中提供了丰富的SDOH信息,通常采用自由文本格式。从自由文本中提取关键信息是一个重大挑战,需要使用自然语言处理(NLP)技术来提取关键信息。目的推进临床文献中SDOH的自动提取。从已发表的文献中整理COVID-19患者的病例报告,创建一个语料库。由专家对部分数据进行标注,生成基础真值标签,采用半监督学习方法对语料库进行重新标注。方法开发了一个自然语言处理框架,并对其进行了测试。采用双向评价方法对方法的数量和质量进行评价。结果提出的NER实现在我们的测试集上达到了92.98%的准确率(f1分数),并且在基准数据上有很好的泛化。对实例的仔细分析证明了所提出的方法在正确分类命名实体方面的优越性。结论NLP可以从自由文本中提取关键信息,如SDOH因子。为了进一步改善医疗保健结果,需要更准确地了解SDOH。
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引用次数: 0
A protocol for the development and validation of a virtual reality-based clinical test of social cognition 基于虚拟现实的社会认知临床测试的开发和验证协议
Pub Date : 2023-09-07 DOI: 10.1186/s44247-023-00036-x
M. Matre, T. Johansen, A. Olsen, S. Tornås, AC Martinsen, A. Lund, F. Becker, C. Brunborg, J. Spikman, J. Ponsford, D. Neumann, S. McDonald, M. Løvstad
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引用次数: 0
The qualities of patients interested in using a game-based digital mental health intervention for depression: a sequential mixed methods study 对使用基于游戏的数字心理健康干预治疗抑郁症感兴趣的患者的素质:一项连续混合方法研究
Pub Date : 2023-09-07 DOI: 10.1186/s44247-023-00037-w
Lauri Lukka, Antti Salonen, M. Vesterinen, Veli-Matti Karhulahti, S. Palva, J. Palva
{"title":"The qualities of patients interested in using a game-based digital mental health intervention for depression: a sequential mixed methods study","authors":"Lauri Lukka, Antti Salonen, M. Vesterinen, Veli-Matti Karhulahti, S. Palva, J. Palva","doi":"10.1186/s44247-023-00037-w","DOIUrl":"https://doi.org/10.1186/s44247-023-00037-w","url":null,"abstract":"","PeriodicalId":72426,"journal":{"name":"BMC digital health","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42471605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Barriers and facilitators to patient-to-provider messaging using the COM-B model and theoretical domains framework: a rapid umbrella review 使用COM-B模型和理论领域框架进行患者与提供者信息传递的障碍和促进因素:快速总括审查
Pub Date : 2023-09-05 DOI: 10.1186/s44247-023-00033-0
Megan M. MacPherson, Shabana Kapadia
{"title":"Barriers and facilitators to patient-to-provider messaging using the COM-B model and theoretical domains framework: a rapid umbrella review","authors":"Megan M. MacPherson, Shabana Kapadia","doi":"10.1186/s44247-023-00033-0","DOIUrl":"https://doi.org/10.1186/s44247-023-00033-0","url":null,"abstract":"","PeriodicalId":72426,"journal":{"name":"BMC digital health","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44938484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Digitalization of home-based records for maternal, newborn, and child health: a scoping review 基于家庭的孕产妇、新生儿和儿童健康记录数字化:范围综述
Pub Date : 2023-09-04 DOI: 10.1186/s44247-023-00032-1
M. Geldof, Nina Gerlach, A. Portela
{"title":"Digitalization of home-based records for maternal, newborn, and child health: a scoping review","authors":"M. Geldof, Nina Gerlach, A. Portela","doi":"10.1186/s44247-023-00032-1","DOIUrl":"https://doi.org/10.1186/s44247-023-00032-1","url":null,"abstract":"","PeriodicalId":72426,"journal":{"name":"BMC digital health","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42413801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
BMC digital health
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