Pub Date : 2024-01-17DOI: 10.1016/j.ccmp.2024.100128
Vivek P. Chavda , Shreya S Sonak , Pankti C. Balar , Krupa Vyas , Pranali Palandurkar , Komal Mule , Krishna Patel , Vivek Hala , Dixa A. Vaghela , Devarshi Acharya , Akta Vaishnav , Jimil Gandhi , Vasso Apostolopoulos
Background
Male infertility poses a growing challenge to the healthcare system, with its prevalence on the rise. Unhealthy lifestyle, food, and addictions such as smoking, alcoholism, etc. accelerate the occurrence. While several approaches are being investigated to prevent and treat this condition, each therapeutic approach has its drawbacks. Traditional medications continue to play a crucial role in the healthcare system. In recent years, there has been a shift towards determining the efficacy of phytochemicals (or, herbal drugs) as remedies.
Objective
To evaluate the effect of various herbs, plant, metabolites, or a part of plant in management of non-genetic male infertility.
Methods
The male infertility-associated keywords were searched in PubMed, excluding those non-English writen papers. A total of 146 pertinent and closely connected records were included for full reading and inclusion in the systemic evaluation.
Results
The manuscript focuses on individual herbal drug components, their active ingredients, their role in improving the condition and quality of life, and decreasing the prevalence of male infertility.
Conclusion
Herbal medicinal plants show promising outcomes to treat male infertility. Herbal alternatives are appealing and have regained popularity. The future holds promise for some of these herbal treatments to advance with many showing improved outcomes in males with infertility issues.
{"title":"Reviving Fertility: Phytochemicals as Natural Allies in the Fight against Non-genetic Male Infertility","authors":"Vivek P. Chavda , Shreya S Sonak , Pankti C. Balar , Krupa Vyas , Pranali Palandurkar , Komal Mule , Krishna Patel , Vivek Hala , Dixa A. Vaghela , Devarshi Acharya , Akta Vaishnav , Jimil Gandhi , Vasso Apostolopoulos","doi":"10.1016/j.ccmp.2024.100128","DOIUrl":"10.1016/j.ccmp.2024.100128","url":null,"abstract":"<div><h3>Background</h3><p>Male infertility poses a growing challenge to the healthcare system, with its prevalence on the rise. Unhealthy lifestyle, food, and addictions such as smoking, alcoholism, etc. accelerate the occurrence. While several approaches are being investigated to prevent and treat this condition, each therapeutic approach has its drawbacks. Traditional medications continue to play a crucial role in the healthcare system. In recent years, there has been a shift towards determining the efficacy of phytochemicals (or, herbal drugs) as remedies.</p></div><div><h3>Objective</h3><p>To evaluate the effect of various herbs, plant, metabolites, or a part of plant in management of non-genetic male infertility.</p></div><div><h3>Methods</h3><p>The male infertility-associated keywords were searched in PubMed, excluding those non-English writen papers. A total of 146 pertinent and closely connected records were included for full reading and inclusion in the systemic evaluation.</p></div><div><h3>Results</h3><p>The manuscript focuses on individual herbal drug components, their active ingredients, their role in improving the condition and quality of life, and decreasing the prevalence of male infertility.</p></div><div><h3>Conclusion</h3><p>Herbal medicinal plants show promising outcomes to treat male infertility. Herbal alternatives are appealing and have regained popularity. The future holds promise for some of these herbal treatments to advance with many showing improved outcomes in males with infertility issues.</p></div>","PeriodicalId":72608,"journal":{"name":"Clinical complementary medicine and pharmacology","volume":"4 1","pages":"Article 100128"},"PeriodicalIF":0.0,"publicationDate":"2024-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772371224000019/pdfft?md5=083ee448ca43e6b94fc8fdf1b3b9c542&pid=1-s2.0-S2772371224000019-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139632996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-14DOI: 10.1016/j.ccmp.2023.100127
Kaixin Gao , Qi Liang , Dongyun Li , Chuanning Li , Maojie Wang , Xiumin Chen , Qingchun Huang , Zehuai Wen , Per-Johan Jakobsson , Runyue Huang
Background
Rheumatoid arthritis (RA) is a worldwide public health problem. Intervention and prevention before the onset of rheumatic diseases is a new direction in current research.
Objective
The aim of this study was to evaluate the potential and feasibility of traditional Chinese medicine (TCM) in the prevention of RA.
Methods
This was a single-armed prospective clinical trial. All participants were recruited from a single center in Guangdong, China. Adults who were tested positive for anti-cyclic citrullinated peptide antibody (anti-CCP) and/or rheumatoid factor (RF), had no synovitis and had never been treated with disease-modifying anti-rheumatic drugs (DMARDs), were enrolled to take the Huayu-Qiangshen-Tongbi (HQT) decoction orally twice daily, 200 mL each time for 24 weeks. Primary outcome was the proportion of patients who met 2010 ACR(American College of Rheumatology)/EULAR(European League Against Rheumatism) classification criteria of RA during observation. Secondary outcomes included levels of anti-CCP, RF, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), assessment of signs and symptoms, and radiographic progression by magnetic resonance imaging (MRI).
Results
19 individuals were enrolled in the study, 4 of which withdrew because of the epidemic of COVID-19. During the observation period, 3 individuals (20%) developed RA and they had longer morning stiffness (P = 0.009) and more obvious synovial enhancement in MRI (P = 0.041) at baseline when compared with those who did not develop RA. After 24 weeks of intervention, there were improvements in 28-swollen joint count (SJC28) (P = 0.046), Visual Analog Scale (VAS) (P = 0.019), Patient's Global Assessment (PtGA) (P = 0.019) and Physician's Global Assessment (PGA) (P = 0.031), but no statistical significance was observed in the levels of anti-CCP, RF, ESR, CRP, morning stiffness, 28-tender joint count (TJC28), Health Assessment Questionnaire (HAQ) and magnetic resonance imaging (MRI) analysis (P > 0.05).
Conclusion
The HQT formula is safe and could improve joint symptoms and signs in these at-risk individuals, but it remains to be investigated in futher study to see if it might potentially reduce the risk of developing RA. Besides, for individuals at high risk to develop RA, morning stiffness and synovial enhancement in MRI might be predictive factors and warning signs.
{"title":"May Traditional Chinese Medicine Reduce the Risk of Developing Rheumatoid Arthritis? An One-armed Prospective Study","authors":"Kaixin Gao , Qi Liang , Dongyun Li , Chuanning Li , Maojie Wang , Xiumin Chen , Qingchun Huang , Zehuai Wen , Per-Johan Jakobsson , Runyue Huang","doi":"10.1016/j.ccmp.2023.100127","DOIUrl":"10.1016/j.ccmp.2023.100127","url":null,"abstract":"<div><h3>Background</h3><p>Rheumatoid arthritis (RA) is a worldwide public health problem. Intervention and prevention before the onset of rheumatic diseases is a new direction in current research.</p></div><div><h3>Objective</h3><p>The aim of this study was to evaluate the potential and feasibility of traditional Chinese medicine (TCM) in the prevention of RA.</p></div><div><h3>Methods</h3><p>This was a single-armed prospective clinical trial. All participants were recruited from a single center in Guangdong, China. Adults who were tested positive for anti-cyclic citrullinated peptide antibody (anti-CCP) and/or rheumatoid factor (RF), had no synovitis and had never been treated with disease-modifying anti-rheumatic drugs (DMARDs), were enrolled to take the Huayu-Qiangshen-Tongbi (HQT) decoction orally twice daily, 200 mL each time for 24 weeks. Primary outcome was the proportion of patients who met 2010 ACR(American College of Rheumatology)/EULAR(European League Against Rheumatism) classification criteria of RA during observation. Secondary outcomes included levels of anti-CCP, RF, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), assessment of signs and symptoms, and radiographic progression by magnetic resonance imaging (MRI).</p></div><div><h3>Results</h3><p>19 individuals were enrolled in the study, 4 of which withdrew because of the epidemic of COVID-19. During the observation period, 3 individuals (20%) developed RA and they had longer morning stiffness (<em>P</em> = 0.009) and more obvious synovial enhancement in MRI (<em>P</em> = 0.041) at baseline when compared with those who did not develop RA. After 24 weeks of intervention, there were improvements in 28-swollen joint count (SJC28) (<em>P</em> = 0.046), Visual Analog Scale (VAS) (<em>P</em> = 0.019), Patient's Global Assessment (PtGA) (<em>P</em> = 0.019) and Physician's Global Assessment (PGA) (<em>P</em> = 0.031), but no statistical significance was observed in the levels of anti-CCP, RF, ESR, CRP, morning stiffness, 28-tender joint count (TJC28), Health Assessment Questionnaire (HAQ) and magnetic resonance imaging (MRI) analysis (<em>P</em> > 0.05).</p></div><div><h3>Conclusion</h3><p>The HQT formula is safe and could improve joint symptoms and signs in these at-risk individuals, but it remains to be investigated in futher study to see if it might potentially reduce the risk of developing RA. Besides, for individuals at high risk to develop RA, morning stiffness and synovial enhancement in MRI might be predictive factors and warning signs.</p></div>","PeriodicalId":72608,"journal":{"name":"Clinical complementary medicine and pharmacology","volume":"4 1","pages":"Article 100127"},"PeriodicalIF":0.0,"publicationDate":"2024-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772371223000499/pdfft?md5=9c15098abffb935ec2f2935764dc83dc&pid=1-s2.0-S2772371223000499-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139538516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-13DOI: 10.1016/j.ccmp.2024.100129
Madhav Nilakanth Mugale , Kapil Dev , Bhumika S. More , Vaishali Sunil Mishra , Kaveri R. Washimkar , Kishan Singh , Rakesh Maurya , Srikanta Kumar Rath , Debprasad Chattopadhyay , Naibedya Chattopadhyay
Background
Globally, 80% people use plant-derived products for treating or preventing diseases. One prevalent perception about medicinal plants is that they are safe and devoid of adverse effects, however, approximately 1,50,000 plants contain toxic substances.
Objective
The present review focuses on medicinal plant extracts/fractions toxicity assessments made in preclinical models by oral route.
Methods
Detail studies were searched from databases including PubMed and Google Scholar. A manual reference screening of the selected studies was done to identify relevant articles, with no language restriction being imposed at the time of searching.
Results
The studies included were performed in rodents, and the test substances were administered orally. Our search revealed 33 widely used plants or products with significant toxicity, and phytochemicals from these plants have been summarized. Through a systematic review, we identified a plethora of medicinal plant extracts reporting safety and toxicity concerns.
Conclusion
In the future, preclinical toxicokinetic studies of herbs and the determination of their no-observed-adverse-effect levels are required for a complete safety assessment. Finally, the interaction of herbs with commonly used/over-the-counter drugs in terms of the latter's metabolic profile should be undertaken.
{"title":"A Comprehensive Review on Preclinical Safety and Toxicity of Medicinal Plants","authors":"Madhav Nilakanth Mugale , Kapil Dev , Bhumika S. More , Vaishali Sunil Mishra , Kaveri R. Washimkar , Kishan Singh , Rakesh Maurya , Srikanta Kumar Rath , Debprasad Chattopadhyay , Naibedya Chattopadhyay","doi":"10.1016/j.ccmp.2024.100129","DOIUrl":"10.1016/j.ccmp.2024.100129","url":null,"abstract":"<div><h3>Background</h3><p>Globally, 80% people use plant-derived products for treating or preventing diseases. One prevalent perception about medicinal plants is that they are safe and devoid of adverse effects, however, approximately 1,50,000 plants contain toxic substances.</p></div><div><h3>Objective</h3><p>The present review focuses on medicinal plant extracts/fractions toxicity assessments made in preclinical models by oral route.</p></div><div><h3>Methods</h3><p>Detail studies were searched from databases including PubMed and Google Scholar. A manual reference screening of the selected studies was done to identify relevant articles, with no language restriction being imposed at the time of searching.</p></div><div><h3>Results</h3><p>The studies included were performed in rodents, and the test substances were administered orally. Our search revealed 33 widely used plants or products with significant toxicity, and phytochemicals from these plants have been summarized. Through a systematic review, we identified a plethora of medicinal plant extracts reporting safety and toxicity concerns.</p></div><div><h3>Conclusion</h3><p>In the future, preclinical toxicokinetic studies of herbs and the determination of their no-observed-adverse-effect levels are required for a complete safety assessment. Finally, the interaction of herbs with commonly used/over-the-counter drugs in terms of the latter's metabolic profile should be undertaken.</p></div>","PeriodicalId":72608,"journal":{"name":"Clinical complementary medicine and pharmacology","volume":"4 1","pages":"Article 100129"},"PeriodicalIF":0.0,"publicationDate":"2024-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772371224000020/pdfft?md5=7124034f68873fcf876345ceda33a739&pid=1-s2.0-S2772371224000020-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139540018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-21DOI: 10.1016/j.ccmp.2023.100126
Du Yaoting , Liu Lin , Niu Zhenzhen , Guan Xihong , Zeng Bowen
Background
Rheumatoid arthritis (RA), a chronic autoimmune disease, has a high incidence and disability rate, causing patients significant discomfort. Although several medicines can be effective, it is also associated with significant adverse effects. In contrast, fumigation as one of the most often used traditional Chinese medicine (TCM) external therapy has shown both efficacy and safety with less side effect. In light of this, we complement western medicine treatment with TCM fumigation therapy to improve patients' clinical efficacy, alleviate symptoms, and improve prognosis.
Objective
To investigate the therapeutic effect of TCM fumigation and western medicine combined therapy in treating RA patients with cold-dampness Bi syndrome.
Methods
A single-center, randomized, controlled study was designed. From January 2022 to December 2022, a total of 60 RA patients with cold-dampness Bi syndrome were enrolled in the study. The control group (30 cases) received conventional western medicine treatment with methotrexate for 4 weeks, while the observation group (30 cases) for 4 weeks received a combination of TCM fumigation treatment and conventional western medicine. The effects of the two groups were comprehensively compared, including the changes in TCM symptom scores and laboratory indicators, as well as the use of visual analogue scale (VAS) and health status rating scale (HAQ) before and after treatment.
Results
The total effective rate of the observation group was 93.3%, which was significantly higher than that of the control group, which is 70% (P < 0.05). Before treatment, there were no significant differences in joint functional activity, pain visual analogue scale (VAS), health assessment questionnaire (HAQ-DI) and laboratory indexes between the two groups (P > 0.05). After treatment, each group compared to their initial condition, respectively, showed major improvement of joint functional activity and significantly decreased VAS, HAQ-DI, and RA-related biomarkers (P < 0.05); inter-group comparison of these indicators showed significanty further enhanced effect of TCM fumigation combined therapy on the RA-related biomarkers and joint functional activity of patients (P < 0.05), yet the control group receiving only western medicine showed better results of the VAS and HAQ-DI .
Conclusion
The TCM fumigation combined therapy is effective to treat RA patients with cold-dampness Bi syndrome,.and to enhance their life quality, improving the joint function, and reducing inflammation.
背景类风湿性关节炎（RA）是一种慢性自身免疫性疾病，发病率和致残率都很高，给患者带来极大的不适。虽然有多种药物可以有效治疗，但也会产生明显的不良反应。相比之下，熏蒸作为最常用的传统中医外治法之一，具有疗效好、安全性高、副作用小等特点。有鉴于此，我们在西医治疗的基础上辅以中医熏蒸疗法，以提高患者的临床疗效，缓解症状，改善预后。 Objective To investigate the therapeutic fumigation and western medicine combined therapy in treating RA patients with cold-dampness Bi syndrome.Methods设计了一项单中心、随机对照研究。自 2022 年 1 月至 2022 年 12 月，共纳入 60 例寒湿痹阻证 RA 患者。对照组（30 例）接受常规西药甲氨蝶呤治疗 4 周，观察组（30 例）接受中医熏蒸治疗与常规西药联合治疗 4 周。综合比较两组疗效，包括治疗前后中医症状评分、化验指标的变化，以及视觉模拟量表（VAS）和健康状况评分量表（HAQ）的使用情况。结果观察组总有效率为93.3%，明显高于对照组的70%（P< 0.05）。治疗前，两组患者的关节功能活动度、疼痛视觉模拟量表（VAS）、健康评估问卷（HAQ-DI）及实验室指标无明显差异（P> 0.05）。治疗后，两组患者的关节功能活动均较治疗前有明显改善，VAS、HAQ-DI及RA相关生物标志物均明显下降（P < 0.05）；两组间指标比较显示，中医熏蒸联合治疗对患者RA相关生物标志物及关节功能活动的影响明显增强（P < 0.结论 中医熏蒸联合疗法治疗寒湿痹阻型RA患者疗效显著，可提高患者生活质量，改善关节功能，减轻炎症反应。
{"title":"Efficacy of TCM Fumigation Using Dampness-and-cold-dispelling Formula Combined with Methotrexate and Leflunomide Treating Rheumatoid Arthritis with Cold-dampness Bi Syndrome","authors":"Du Yaoting , Liu Lin , Niu Zhenzhen , Guan Xihong , Zeng Bowen","doi":"10.1016/j.ccmp.2023.100126","DOIUrl":"10.1016/j.ccmp.2023.100126","url":null,"abstract":"<div><h3>Background</h3><p>Rheumatoid arthritis (RA), a chronic autoimmune disease, has a high incidence and disability rate, causing patients significant discomfort. Although several medicines can be effective, it is also associated with significant adverse effects. In contrast, fumigation as one of the most often used traditional Chinese medicine (TCM) external therapy has shown both efficacy and safety with less side effect. In light of this, we complement western medicine treatment with TCM fumigation therapy to improve patients' clinical efficacy, alleviate symptoms, and improve prognosis.</p></div><div><h3>Objective</h3><p>To investigate the therapeutic effect of TCM fumigation and western medicine combined therapy in treating RA patients with cold-dampness <em>Bi</em> syndrome.</p></div><div><h3>Methods</h3><p>A single-center, randomized, controlled study was designed. From January 2022 to December 2022, a total of 60 RA patients with cold-dampness <em>Bi</em> syndrome were enrolled in the study. The control group (30 cases) received conventional western medicine treatment with methotrexate for 4 weeks, while the observation group (30 cases) for 4 weeks received a combination of TCM fumigation treatment and conventional western medicine. The effects of the two groups were comprehensively compared, including the changes in TCM symptom scores and laboratory indicators, as well as the use of visual analogue scale (VAS) and health status rating scale (HAQ) before and after treatment.</p></div><div><h3>Results</h3><p>The total effective rate of the observation group was 93.3%, which was significantly higher than that of the control group, which is 70% (<em>P</em> < 0.05). Before treatment, there were no significant differences in joint functional activity, pain visual analogue scale (VAS), health assessment questionnaire (HAQ-DI) and laboratory indexes between the two groups (<em>P</em> > 0.05). After treatment, each group compared to their initial condition, respectively, showed major improvement of joint functional activity and significantly decreased VAS, HAQ-DI, and RA-related biomarkers (<em>P</em> < 0.05); inter-group comparison of these indicators showed significanty further enhanced effect of TCM fumigation combined therapy on the RA-related biomarkers and joint functional activity of patients (<em>P</em> < 0.05), yet the control group receiving only western medicine showed better results of the VAS and HAQ-DI .</p></div><div><h3>Conclusion</h3><p>The TCM fumigation combined therapy is effective to treat RA patients with cold-dampness <em>Bi</em> syndrome,.and to enhance their life quality, improving the joint function, and reducing inflammation.</p></div>","PeriodicalId":72608,"journal":{"name":"Clinical complementary medicine and pharmacology","volume":"4 1","pages":"Article 100126"},"PeriodicalIF":0.0,"publicationDate":"2023-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772371223000487/pdfft?md5=300c6f1267d69df0524b55d7cda8c0f6&pid=1-s2.0-S2772371223000487-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139014860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-02DOI: 10.1016/j.ccmp.2023.100125
Iffat Ara , Rita Turcio , Tasmia Islam , Md. Sabbir Hossain , Md. Kamrul Hasan
Background
Licochalcone A (LCA) is a flavonoid derived from the roots of Glycyrrhiza uralensis Fisch. ex DC and other related plants. Its natural source has been extensively used in complementary medicine, especially traditional Chinese medicine, to treat various ailments. Identified as a phenolic chalcone compound, LCA has gained significant attention in recent years due to its various pharmacological properties.
Objective
The objective of this review article is to assess the auti-aging ralated pharmacological properties of licochalcone A.
Method
An exhaustive search of several scientific databases was conducted using various relevant keywords to write this review article on LCA, focusing on its therapeutic applications and anti-aging-related pharmacological activities. Some inclusion and exclusion criteria were strictly followed to retrieve updated relevant articles.
Results
A collection of 292 papers were screened, and 131 were included in this review for an in-depth analysis of Licochalcone A, focusing on its anti-aging-related pharmacological activities and relevant mechanisms, and its toxicity and side effects. Moreover, the potential of LCA as a pharmacological product is discussed, emphasizing its health benefits and potential as a pharmaceutical product.
Conclusion
These findings indicate that Licochalcone A is a promising natural therapeutic agent for anti-aging therapy and other ailments.
背景甘草查耳酮 A（Licochalcone A，LCA）是一种黄酮类化合物，提取自甘草（Glycyrrhiza uralensis Fisch.它的天然来源已被广泛用于辅助医学，特别是传统中医学，以治疗各种疾病。本综述文章的目的是评估甘草查耳酮 A 的抗衰老药理特性。方法：为了撰写这篇关于甘草查耳酮的综述文章，我们使用各种相关关键词对多个科学数据库进行了详尽的检索，重点关注其治疗应用和抗衰老相关的药理活性。结果 筛选出 292 篇论文，其中 131 篇被纳入本综述，对李可查酮 A 进行了深入分析，重点关注其抗衰老相关药理活性和相关机制，以及其毒性和副作用。结论这些研究结果表明，李可查酮 A 是一种很有前景的天然治疗剂，可用于抗衰老治疗和其他疾病的治疗。
{"title":"Anti-aging Related Activities and Health Benefits of Licochalcone A: A Review","authors":"Iffat Ara , Rita Turcio , Tasmia Islam , Md. Sabbir Hossain , Md. Kamrul Hasan","doi":"10.1016/j.ccmp.2023.100125","DOIUrl":"10.1016/j.ccmp.2023.100125","url":null,"abstract":"<div><h3>Background</h3><p>Licochalcone A (LCA) is a flavonoid derived from the roots of <em>Glycyrrhiza uralensis</em> Fisch. ex DC and other related plants. Its natural source has been extensively used in complementary medicine, especially traditional Chinese medicine, to treat various ailments. Identified as a phenolic chalcone compound, LCA has gained significant attention in recent years due to its various pharmacological properties.</p></div><div><h3>Objective</h3><p>The objective of this review article is to assess the auti-aging ralated pharmacological properties of licochalcone A.</p></div><div><h3>Method</h3><p>An exhaustive search of several scientific databases was conducted using various relevant keywords to write this review article on LCA, focusing on its therapeutic applications and anti-aging-related pharmacological activities. Some inclusion and exclusion criteria were strictly followed to retrieve updated relevant articles.</p></div><div><h3>Results</h3><p>A collection of 292 papers were screened, and 131 were included in this review for an in-depth analysis of Licochalcone A, focusing on its anti-aging-related pharmacological activities and relevant mechanisms, and its toxicity and side effects. Moreover, the potential of LCA as a pharmacological product is discussed, emphasizing its health benefits and potential as a pharmaceutical product.</p></div><div><h3>Conclusion</h3><p>These findings indicate that Licochalcone A is a promising natural therapeutic agent for anti-aging therapy and other ailments.</p></div>","PeriodicalId":72608,"journal":{"name":"Clinical complementary medicine and pharmacology","volume":"4 1","pages":"Article 100125"},"PeriodicalIF":0.0,"publicationDate":"2023-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772371223000475/pdfft?md5=ffadd1e383b2b65150f961c2209c83dc&pid=1-s2.0-S2772371223000475-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138621916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Baliospermum solanifolium is a traditional medicinal plant, locally known as “dantigaacha” from Euphorbiaceae family, and has been used in different diseases treatments likes helminthiasis, skin diseases, diabetes, snake-bite, and leukoderma.
Objectives
Depending on the traditional uses of B. solanifolium and the lack of scientific works, we aimed to conduct some pharmacological tests on its leaves.
Methods
Active constituents of B. solanifolium were assessed by qualitative screening. DPPH (2,2-diphenyl-1-picrylhydrazyl) was used for free radical scavenging assay. Behavioral change and mortality rate were used as indicators to assess the toxicity of B. solanifolium. The antidiabetic potential was evaluated by oral glucose tolerance test (OGTT) and alpha-glucosidase enzyme inhibitory activity. In antidiarrheal activity, castor oil-induced mice were used. Antibacterial test was carried out by disk diffusion assay and MIC determination. Furthermore, analgesic activity was done by acetic acid-induced writhing method.
Results
B. solanifolium contains alkaloids, carbohydrates, glycosides, flavonoids, tannis, phenolics etc. Acute toxicity test ensured the safety of the extract. In DPPH, the extract showed antioxidant activity with an IC50 (concentration needed to scavenge 50% DPPH) value of 61.65 µg/mL. Total phenolic, flavonoid and tannin contents were determined as 124 mg GAE/g, 440 mg QE/g and 344 mg GAE/g dried extract, respectively. In OGTT, the extract reduced the blood glucose level significantly. In the alpha-glucosidase inhibitory activity, the plant showed a concentration-dependent reduction of the enzyme at IC50 of 8.53 mg/mL. In the antidiarrheal test, B. solanifolium inhibit defecation 30.69% and 53.41% at dose 250 mg/kg and 500 mg/kg, respectively. The extract also showed antibacterial activity against four bacterial strains in the disk diffusion method and minimum inhibitory concentration (MIC) values were 62.5 µg/mL, 62.5 µg/mL, 125 µg/mL and 62.5 µg/mL against four bacterial strains, independently. In analgesic activity test, the extract reduced the writhing impulse up to 48.51% at 500 mg/kg dose.
Conclusion
B. solanifolium contains many active phytoconstituents which may be the possible candidates for targeting diabetes, microbial infection, diarrhea and pain in the future.
{"title":"Phytochemical Screening and Evaluation of Pharmacological Potential of Baliospermum solanifolium Leaf Extract","authors":"Amit Mazumder, Rabindra Nath Acharyya, Milton Kumar Kundu, Pritam Kundu, Md. Amirul Islam, Md. Mustafizur Rahman","doi":"10.1016/j.ccmp.2023.100123","DOIUrl":"10.1016/j.ccmp.2023.100123","url":null,"abstract":"<div><h3>Background</h3><p><em>Baliospermum solanifolium</em> is a traditional medicinal plant, locally known as “dantigaacha” from Euphorbiaceae family, and has been used in different diseases treatments likes helminthiasis, skin diseases, diabetes, snake-bite, and leukoderma.</p></div><div><h3>Objectives</h3><p>Depending on the traditional uses of <em>B. solanifolium</em> and the lack of scientific works<em>,</em> we aimed to conduct some pharmacological tests on its leaves.</p></div><div><h3>Methods</h3><p>Active constituents of <em>B. solanifolium</em> were assessed by qualitative screening. DPPH (2,2-diphenyl-1-picrylhydrazyl) was used for free radical scavenging assay. Behavioral change and mortality rate were used as indicators to assess the toxicity of <em>B. solanifolium</em>. The antidiabetic potential was evaluated by oral glucose tolerance test (OGTT) and alpha-glucosidase enzyme inhibitory activity. In antidiarrheal activity, castor oil-induced mice were used. Antibacterial test was carried out by disk diffusion assay and MIC determination. Furthermore, analgesic activity was done by acetic acid-induced writhing method.</p></div><div><h3>Results</h3><p><em>B. solanifolium</em> contains alkaloids, carbohydrates, glycosides, flavonoids, tannis, phenolics etc. Acute toxicity test ensured the safety of the extract. In DPPH, the extract showed antioxidant activity with an IC<sub>50</sub> (concentration needed to scavenge 50% DPPH) value of 61.65 µg/mL. Total phenolic, flavonoid and tannin contents were determined as 124 mg GAE/g, 440 mg QE/g and 344 mg GAE/g dried extract, respectively. In OGTT, the extract reduced the blood glucose level significantly. In the alpha-glucosidase inhibitory activity, the plant showed a concentration-dependent reduction of the enzyme at IC<sub>50</sub> of 8.53 mg/mL. In the antidiarrheal test, <em>B. solanifolium</em> inhibit defecation 30.69% and 53.41% at dose 250 mg/kg and 500 mg/kg, respectively. The extract also showed antibacterial activity against four bacterial strains in the disk diffusion method and minimum inhibitory concentration (MIC) values were 62.5 µg/mL, 62.5 µg/mL, 125 µg/mL and 62.5 µg/mL against four bacterial strains, independently. In analgesic activity test, the extract reduced the writhing impulse up to 48.51% at 500 mg/kg dose.</p></div><div><h3>Conclusion</h3><p><em>B. solanifolium</em> contains many active phytoconstituents which may be the possible candidates for targeting diabetes, microbial infection, diarrhea and pain in the future.</p></div>","PeriodicalId":72608,"journal":{"name":"Clinical complementary medicine and pharmacology","volume":"4 1","pages":"Article 100123"},"PeriodicalIF":0.0,"publicationDate":"2023-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772371223000451/pdfft?md5=0e5098eb8f5de5fafb318b7a58dbc7fb&pid=1-s2.0-S2772371223000451-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139292065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hard mineral and acid salt deposits that clump together in concentrated urine are known as kidney stones. A complicated chain of physicochemical events, including hyper saturation, nucleation, growth, aggregation, and retention in the urinary tract, leads to urolithiasis, the third most prevalent urinary tract issue. Numerous traditional medications and therapies are less successful in treating urolithiasis and frequently cause recurrences.
Objective
The present study is focused on evaluating the anti-urolithiasis activities of the polyherbal formulation prepared from Spinacia oleracea L. and Coriandrum sativum L. seeds.
Methods
To evaluating the anti-urolithiasis activities of the polyherbal formulation prepared from S. oleracea and C. sativum seeds against oxalate crystals by employing an in vitro inhibition, aggregation, and nucleation assay, employing a spectrophotometer followed by microscopic observation, and further monitored by egg semipermeable membrane model, using cystone as a standard drug.
Results
In the present work, the alkaloids, glycosides, flavonoids, glycosides, phenols, saponins, steroids, tannins, terpenoids, and triterpenoids were found in the extracts of S. oleracea and C. sativum. The in vitro assays in the present study clearly indicated that all the mixture extracts readily prevented crystal nucleation, growth and aggregation. The aqueous extract of the mixture inhibited significant inhibitory potential against the crystallization process.
Conclusion
It can be said that the phyto-constituents enriched homemade preparation possibly will be used as a medication for the management of kidney stones by dissolving the oxalate stone in the kidney.
背景在浓缩尿液中凝结成块的坚硬矿物质和酸性盐沉淀物被称为肾结石。一连串复杂的物理化学过程，包括高饱和度、成核、生长、聚集以及在尿路中的滞留，导致了尿路结石这一第三大泌尿系统疾病。许多传统药物和疗法在治疗尿路结石方面都不太成功，而且经常导致复发。采用体外抑制、聚集和成核试验，使用分光光度计，然后进行显微镜观察，并以鸡蛋半透膜模型为标准药物，进一步监测其抗草酸盐结晶的活性。结果在本研究中，发现 S. oleracea 和 C. sativum 的提取物中含有生物碱、苷类、黄酮类、糖苷类、酚类、皂苷类、甾体类、单宁酸、萜类和三萜类化合物。本研究中的体外试验清楚地表明，所有混合物提取物都能很容易地阻止晶体成核、生长和聚集。结论可以说，富含植物成分的自制制剂可以通过溶解肾脏中的草酸盐结石来治疗肾结石。
{"title":"An in vitro Anti-urolithiasis Activity of a Herbal Formulation: Spinacia oleracea L. and Coriandrum sativum L.","authors":"Sumathy Raj , Monica Shree Gnana Soundara Rajan , Suganthi Ramasamy , Rimal Isaac Rajamony Suthies Goldy , Ramathilaga Ariyamuthu , Monisha Sudhagar , Sakthivel Gandhi , Prakash Shoba , Manikandan Gurusamy","doi":"10.1016/j.ccmp.2023.100124","DOIUrl":"https://doi.org/10.1016/j.ccmp.2023.100124","url":null,"abstract":"<div><h3>Background</h3><p>Hard mineral and acid salt deposits that clump together in concentrated urine are known as kidney stones. A complicated chain of physicochemical events, including hyper saturation, nucleation, growth, aggregation, and retention in the urinary tract, leads to urolithiasis, the third most prevalent urinary tract issue. Numerous traditional medications and therapies are less successful in treating urolithiasis and frequently cause recurrences.</p></div><div><h3>Objective</h3><p>The present study is focused on evaluating the anti-urolithiasis activities of the polyherbal formulation prepared from <em>Spinacia oleracea</em> L<em>.</em> and <em>Coriandrum sativum</em> L. seeds.</p></div><div><h3>Methods</h3><p>To evaluating the anti-urolithiasis activities of the polyherbal formulation prepared from <em>S. oleracea</em> and <em>C. sativum</em> seeds against oxalate crystals by employing an <em>in vitro</em> inhibition, aggregation, and nucleation assay, employing a spectrophotometer followed by microscopic observation, and further monitored by egg semipermeable membrane model, using cystone as a standard drug.</p></div><div><h3>Results</h3><p>In the present work, the alkaloids, glycosides, flavonoids, glycosides, phenols, saponins, steroids, tannins, terpenoids, and triterpenoids were found in the extracts of <em>S. oleracea</em> and <em>C. sativum</em>. The <em>in vitro</em> assays in the present study clearly indicated that all the mixture extracts readily prevented crystal nucleation, growth and aggregation. The aqueous extract of the mixture inhibited significant inhibitory potential against the crystallization process.</p></div><div><h3>Conclusion</h3><p>It can be said that the phyto-constituents enriched homemade preparation possibly will be used as a medication for the management of kidney stones by dissolving the oxalate stone in the kidney.</p></div>","PeriodicalId":72608,"journal":{"name":"Clinical complementary medicine and pharmacology","volume":"4 1","pages":"Article 100124"},"PeriodicalIF":0.0,"publicationDate":"2023-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772371223000463/pdfft?md5=046c7ab340a7c93285826e0964d3a469&pid=1-s2.0-S2772371223000463-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139548979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In the presence of a stimulus that disrupts homeostasis, the body elicits a response known as inflammation. The inflammatory response is expected to restore the normal functioning of the body and initiate healing where necessary. However, the persistent activity of acute inflammation results in chronic inflammation which causes adverse consequences associated with diseases such as diabetes and arthritis. In traditional medical practice, Vernonia amygdalina is used to treat several ailments such as malaria, fever, diabetes, and inflammatory conditions such as those related to pain and swelling.
Objective
This review seeks to explore and discuss the therapeutic benefits of V. amygdalina in the treatment of inflammation and its associated diseases.
Methods
We reviewed the scientific literature indexed in PubMed, ScienceDirect and Springer, and discussed the reported anti-inflammatory properties of V. amygdalina and its curative activity in inflammation-associated diseases.
Results
A total of 30 published articles were identified describing the therapeutic effect of V. amygdalina in predominately experimental models. The anti-inflammatory properties of V. amygdalina have been linked to the presence of bioactive phytoconstituents predominantly present in the leaves of the plant.
Conclusions
Multiple studies have demonstrated that the aqueous and ethanolic extracts of V. amygdalina can inhibit the production of proinflammatory cytokines and enzymes in inflammatory cells, reducing inflammation and its associated complications. We critically appraise the current evidence, and discuss the potential use of this medicinal plant in the treatment of inflammatory conditions.
{"title":"Therapeutic Benefits of Vernonia amygdalina in the Treatment of Inflammation and Its Associated Diseases","authors":"Du-Bois Asante , Gideon Akuamoah Wiafe , Korantema Mawuena Tsegah , Nelson Kwabla Domey","doi":"10.1016/j.ccmp.2023.100122","DOIUrl":"10.1016/j.ccmp.2023.100122","url":null,"abstract":"<div><h3>Background</h3><p>In the presence of a stimulus that disrupts homeostasis, the body elicits a response known as inflammation. The inflammatory response is expected to restore the normal functioning of the body and initiate healing where necessary. However, the persistent activity of acute inflammation results in chronic inflammation which causes adverse consequences associated with diseases such as diabetes and arthritis. In traditional medical practice, <em>Vernonia amygdalina</em> is used to treat several ailments such as malaria, fever, diabetes, and inflammatory conditions such as those related to pain and swelling.</p></div><div><h3>Objective</h3><p>This review seeks to explore and discuss the therapeutic benefits of <em>V. amygdalina</em> in the treatment of inflammation and its associated diseases.</p></div><div><h3>Methods</h3><p>We reviewed the scientific literature indexed in PubMed, ScienceDirect and Springer, and discussed the reported anti-inflammatory properties of <em>V. amygdalina</em> and its curative activity in inflammation-associated diseases.</p></div><div><h3>Results</h3><p>A total of 30 published articles were identified describing the therapeutic effect of <em>V. amygdalina</em> in predominately experimental models. The anti-inflammatory properties of <em>V. amygdalina</em> have been linked to the presence of bioactive phytoconstituents predominantly present in the leaves of the plant.</p></div><div><h3>Conclusions</h3><p>Multiple studies have demonstrated that the aqueous and ethanolic extracts of <em>V. amygdalina</em> can inhibit the production of proinflammatory cytokines and enzymes in inflammatory cells, reducing inflammation and its associated complications. We critically appraise the current evidence, and discuss the potential use of this medicinal plant in the treatment of inflammatory conditions.</p></div>","PeriodicalId":72608,"journal":{"name":"Clinical complementary medicine and pharmacology","volume":"4 1","pages":"Article 100122"},"PeriodicalIF":0.0,"publicationDate":"2023-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S277237122300044X/pdfft?md5=d13fc61925d0578c34d556bf71082e49&pid=1-s2.0-S277237122300044X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139303756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ayurvedic system of medicine is well established for prevention and treatment of renal problems. There are vast number of medicinal plants mentioned in Ayurvedic system of medicine, including Piper attenuatum Buch.-Ham. ex Miq., are known to exhibits diuretic properties.
Objective
To investigate possible mechanism and diuretic activity of ethanol extract of P. attenuatum leaves.
Methods
Present study reports an in vivo diuretic activity of ethanol extracts of P. attenuatum leaves.Twenty-four Sprague-Dawley male rats were deprived from food and water for 20 h, followed by being divided into four groups to receive normal saline, Furosemide, and two doses of the ethanol extract, respectively. Further, the ethanol extract were subjected for prelimnary phytochemical screening test, and analytical investigation was performed via high-performance thin-layer chromatography (HPTLC), followed by effectiveness exploration of putative bioactive compounds from P. attenuatum against human carbonic anhydrase (hCA) enzyme using molecular docking tool.
Results
During phytochemicals screening, several groups of compounds such as amides, terpenoids, proteins, flavonoids, and glycosides have been identified. Further, HPTLC reveals presence of carbohydrates, proteins, amino acids, steroids, alkaloids, flavonoids, tannins, glycosides, and terpenoids. Significant diuretic action was revealed for both 200 mg/kg bw and 400 mg/kg bw of ethanol extract of P. attenuatum leaves. Interestingly, molecular docking analysis demonstrated greater binding affinity of compounds such as Cepharadione A, Norcepharadione B, Galbelgin, Crotepoxide, and Pipoxide chlorohydrin out of total 23 studied compounds against hCA isoforms (a key biomarker for diuretic) and score is comparable with standard drug Acetazolamide.
Conclusion
It was concluded from the present studies that ethanol extract of P. attenuatum leaves exhibits significant diuretic activity. The activity may be correlated due to the presence of Cepharadione A, Norcepharadione B, Galbelgin, Crotepoxide, and Pipoxide chlorohydrin as key component responsible for inhibition of hCA isoforms.
{"title":"Diuretic Activity of Ethanol Extract of Piper attenuatum Leaves Might Be Due to the Inhibition of Carbonic Anhydrase Enzyme: An in vivo and in silico Investigation","authors":"Shikha Sharma , Gaurav Kumar , Nitin Kumar , Neeraj K. Sethiya , Dheeraj Bisht","doi":"10.1016/j.ccmp.2023.100117","DOIUrl":"https://doi.org/10.1016/j.ccmp.2023.100117","url":null,"abstract":"<div><h3>Background</h3><p>Ayurvedic system of medicine is well established for prevention and treatment of renal problems. There are vast number of medicinal plants mentioned in Ayurvedic system of medicine, including <em>Piper attenuatum</em> Buch.-Ham. ex Miq., are known to exhibits diuretic properties.</p></div><div><h3>Objective</h3><p>To investigate possible mechanism and diuretic activity of ethanol extract of <em>P. attenuatum</em> leaves.</p></div><div><h3>Methods</h3><p>Present study reports an <em>in vivo</em> diuretic activity of ethanol extracts of <em>P. attenuatum</em> leaves.Twenty-four Sprague-Dawley male rats were deprived from food and water for 20 h, followed by being divided into four groups to receive normal saline, Furosemide, and two doses of the ethanol extract, respectively. Further, the ethanol extract were subjected for prelimnary phytochemical screening test, and analytical investigation was performed via high-performance thin-layer chromatography (HPTLC), followed by effectiveness exploration of putative bioactive compounds from <em>P. attenuatum</em> against human carbonic anhydrase (hCA) enzyme using molecular docking tool.</p></div><div><h3>Results</h3><p>During phytochemicals screening, several groups of compounds such as amides, terpenoids, proteins, flavonoids, and glycosides have been identified. Further, HPTLC reveals presence of carbohydrates, proteins, amino acids, steroids, alkaloids, flavonoids, tannins, glycosides, and terpenoids. Significant diuretic action was revealed for both 200 mg/kg bw and 400 mg/kg bw of ethanol extract of <em>P. attenuatum</em> leaves. Interestingly, molecular docking analysis demonstrated greater binding affinity of compounds such as Cepharadione A, Norcepharadione B, Galbelgin, Crotepoxide, and Pipoxide chlorohydrin out of total 23 studied compounds against hCA isoforms (a key biomarker for diuretic) and score is comparable with standard drug Acetazolamide.</p></div><div><h3>Conclusion</h3><p>It was concluded from the present studies that ethanol extract of <em>P. attenuatum</em> leaves exhibits significant diuretic activity. The activity may be correlated due to the presence of Cepharadione A, Norcepharadione B, Galbelgin, Crotepoxide, and Pipoxide chlorohydrin as key component responsible for inhibition of hCA isoforms.</p></div>","PeriodicalId":72608,"journal":{"name":"Clinical complementary medicine and pharmacology","volume":"4 1","pages":"Article 100117"},"PeriodicalIF":0.0,"publicationDate":"2023-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772371223000396/pdfft?md5=39dda6e1c980d12247a9e0dd1b28636e&pid=1-s2.0-S2772371223000396-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92067973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-24DOI: 10.1016/j.ccmp.2023.100116
Olusegun G. Adebayo , Benneth Ben-Azu , Egwonor Akpofure , Modo U. Emmanuel , Iheanyichukwu Wopara , Wadioni Aduema , Lawrence Dayo Adedayo , Jude Ijuo Abeje
Background
Increasing number of people globally gives in to indiscriminate consumption of excess alcohol as a coping mechanism to relieve any form of physical or psychological stress. Previously, ethnomedicinal use of Zingiber officinale Roscoe (Ginger) have been shown to exhibit broad range of pharmacological benefits but no data has reported the phytotherapeutic treatment of Zingiber officinale methanol extract (MEZO) on alcohol-use disorder (AUD) and post-traumatic stress disorder (PTSD)-induced oxidative and inflammatory stress relevant to disruption of kidney functions in animal model.
Objective
To investigate the protective effect of MEZO on kidney-oxidative and inflammatory biomarkers in sub-chronic alcohol exacerbation of PTSD symptoms in mice.
Methods
Male Swiss mice were administered 30% ethanol for two weeks and thereafter introduced to single prolonged stress to induce AUD and PTSD respectively prior to post-treatment with MEZO and vitamin C. Markers of oxidative stress, inflammatory cytokines, kidney functions, HPA-axis signaling molecules, vasodilator substance, and histopathology of the kidney were evaluated.
Results
Sub-chronic alcohol intoxication heightened PTSD-induced oxido-inflammatory stress, altered the kidney function indices and HPA-axis, and reduced nitric oxide production, which were ameliorated by the phytotherapeutic treatment with MEZO. Furthermore, severe degeneration and atrophy of renal tubules were observed. Meanwhile, MEZO interventions strongly abated all these effects.
Conclusions
Herein, the study shows that phytotherapeutic treatment with MEZO prevents the damaging effects of co-exposure to sub-chronic alcohol intoxication and PTSD.
{"title":"Zingiber officinale (Ginger) Methanol Extract Abates Kidney Dysfunction in Mice Co-exposed to Sub-chronic Alcohol Intoxication and Post-traumatic Stress Disorder","authors":"Olusegun G. Adebayo , Benneth Ben-Azu , Egwonor Akpofure , Modo U. Emmanuel , Iheanyichukwu Wopara , Wadioni Aduema , Lawrence Dayo Adedayo , Jude Ijuo Abeje","doi":"10.1016/j.ccmp.2023.100116","DOIUrl":"https://doi.org/10.1016/j.ccmp.2023.100116","url":null,"abstract":"<div><h3>Background</h3><p>Increasing number of people globally gives in to indiscriminate consumption of excess alcohol as a coping mechanism to relieve any form of physical or psychological stress. Previously, ethnomedicinal use of <em>Zingiber officinale</em> Roscoe (Ginger) have been shown to exhibit broad range of pharmacological benefits but no data has reported the phytotherapeutic treatment of <em>Zingiber officinale</em> methanol extract (MEZO) on alcohol-use disorder (AUD) and post-traumatic stress disorder (PTSD)-induced oxidative and inflammatory stress relevant to disruption of kidney functions in animal model.</p></div><div><h3>Objective</h3><p>To investigate the protective effect of MEZO on kidney-oxidative and inflammatory biomarkers in sub-chronic alcohol exacerbation of PTSD symptoms in mice.</p></div><div><h3>Methods</h3><p>Male Swiss mice were administered 30% ethanol for two weeks and thereafter introduced to single prolonged stress to induce AUD and PTSD respectively prior to post-treatment with MEZO and vitamin C. Markers of oxidative stress, inflammatory cytokines, kidney functions, HPA-axis signaling molecules, vasodilator substance, and histopathology of the kidney were evaluated.</p></div><div><h3>Results</h3><p>Sub-chronic alcohol intoxication heightened PTSD-induced oxido-inflammatory stress, altered the kidney function indices and HPA-axis, and reduced nitric oxide production, which were ameliorated by the phytotherapeutic treatment with MEZO. Furthermore, severe degeneration and atrophy of renal tubules were observed. Meanwhile, MEZO interventions strongly abated all these effects.</p></div><div><h3>Conclusions</h3><p>Herein, the study shows that phytotherapeutic treatment with MEZO prevents the damaging effects of co-exposure to sub-chronic alcohol intoxication and PTSD.</p></div>","PeriodicalId":72608,"journal":{"name":"Clinical complementary medicine and pharmacology","volume":"3 4","pages":"Article 100116"},"PeriodicalIF":0.0,"publicationDate":"2023-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49751685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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