Clinical complementary medicine and pharmacology最新文献

英文中文

Epigenetic and Transcriptional Modulator Potential of Epigallocatechin-3-gallate and Genistein on Fetal Hemoglobin Reactivators Genes 表没食子儿茶素-3-没食子酸酯和染料木素对胎儿血红蛋白再激活基因的表观遗传学和转录调控潜力

Clinical complementary medicine and pharmacology

Pub Date : 2022-06-01 DOI: 10.1016/j.ccmp.2022.100034

Edna Ribeiro , Mariana Delgadinho , Elisabete Matos , Raquel Santos , Daniela Sousa , Heloísa Galante , Miguel Brito

Background

β-hemoglobinopathies are one of the most common recessive genetic diseases worldwide, with limited treatments available, particularly in developed countries where the prevalence is higher. Pharmacological reactivation of Fetal Hemoglobin (HbF) is a promising therapeutic strategy. However, approximately 25% of the patients do not respond to Hydroxyurea (HU), the first and most commonly used HbF inducing agent approved by the FDA.

Objective

Here, we performed an in vitro assessment of transcriptional effects induced by natural bioactive compounds, namely Epigallocatechin-3-gallate (EGCG) and genistein (GN) in globin genes (HBA1, HBB, HBG1 and HBG2) in HbF regulators/silencer genes (KLF1, BCL11A, MYB and BGLT3) and in epigenetic regulator genes (DNMT1, DNMT3A, DNMT3B, HDAC1, HDAC2, HDAC3 and HDAC8). Moreover, we evaluated EGCG’s in vivo effects in hematological parameters of healthy volunteers.

Methods

K562 cells were exposed for 72 and 96 h to GN and EGCG at 100, 250 and 500 ng/mL. Cell proliferation and viability were measured, and transcriptional levels were evaluated by qRT-PCR. For in vivo assay, complete blood count was determined by flow cytometry and HbF level was determined through HPLC in 30 healthy individuals before and after 225 mg EGCG ingestion per day during a 90-day period.

Results

Both compounds impact cellular metabolism and proliferation with no cytotoxic effects. Divergent GN and EGCG effects in globin and BGLT3 expression levels suggest the involvement of divergent signaling pathways. As for the epigenetic potential, EGCG particularly affects HDAC2 and HDAC8 transcription, whereas GN significantly affects expression patterns of methylation and acetylation modulators. HU appears to have time divergent effects, with greater impact in methylation at 72 h (overregulates DNTM3A) while affecting acetylation mostly at 96 h (downregulates HDAC1 and HDAC8). Additionally, in vivo, EGCG demonstrated a modulator effect in hematopoiesis and HbF induction.

Conclusion

Our results advocate EGCG and GN with HbF pharmacological reactivation potential and sustain further research as new alternative approaches for β-hemoglobinopathies therapies.

β-血红蛋白病是世界上最常见的隐性遗传病之一，治疗方法有限，特别是在患病率较高的发达国家。胎儿血红蛋白(HbF)的药物再激活是一种很有前途的治疗策略。然而，大约25%的患者对羟基脲(HU)没有反应，羟基脲是FDA批准的第一种也是最常用的HbF诱导剂。目的:在体外研究天然生物活性化合物表没食子儿茶素-3-没食子酸酯(EGCG)和染料木素(GN)对珠蛋白基因(HBA1、HBB、HBG1和HBG2)、HbF调控/沉默基因(KLF1、BCL11A、MYB和BGLT3)和表观遗传调控基因(DNMT1、DNMT3A、DNMT3B、HDAC1、HDAC2、HDAC3和HDAC8)的转录效应。此外，我们还评估了EGCG对健康志愿者血液学参数的体内影响。方法将sk562细胞分别暴露于100、250和500 ng/mL的GN和EGCG中72和96 h。检测细胞增殖和活力，用qRT-PCR检测转录水平。在体内实验中，30名健康个体在90天内每天摄入225mg EGCG之前和之后，通过流式细胞术测定全血细胞计数，并通过高效液相色谱测定HbF水平。结果两种化合物均影响细胞代谢和增殖，但无细胞毒性作用。GN和EGCG对球蛋白和BGLT3表达水平的不同影响表明参与了不同的信号通路。在表观遗传潜力方面，EGCG尤其影响HDAC2和HDAC8的转录，而GN则显著影响甲基化和乙酰化调节剂的表达模式。HU似乎具有时间发散效应，在72 h时对甲基化的影响更大(过度调节DNTM3A)，而在96 h时主要影响乙酰化(下调HDAC1和HDAC8)。此外，在体内，EGCG在造血和HbF诱导中表现出调节作用。结论EGCG和GN具有HbF药理再激活潜力，可作为治疗β-血红蛋白病的新途径，有待进一步研究。

{"title":"Epigenetic and Transcriptional Modulator Potential of Epigallocatechin-3-gallate and Genistein on Fetal Hemoglobin Reactivators Genes","authors":"Edna Ribeiro , Mariana Delgadinho , Elisabete Matos , Raquel Santos , Daniela Sousa , Heloísa Galante , Miguel Brito","doi":"10.1016/j.ccmp.2022.100034","DOIUrl":"10.1016/j.ccmp.2022.100034","url":null,"abstract":"<div><h3>Background</h3><p>β-hemoglobinopathies are one of the most common recessive genetic diseases worldwide, with limited treatments available, particularly in developed countries where the prevalence is higher. Pharmacological reactivation of Fetal Hemoglobin (HbF) is a promising therapeutic strategy. However, approximately 25% of the patients do not respond to Hydroxyurea (HU), the first and most commonly used HbF inducing agent approved by the FDA.</p></div><div><h3>Objective</h3><p>Here, we performed an <em>in vitro</em> assessment of transcriptional effects induced by natural bioactive compounds, namely Epigallocatechin-3-gallate (EGCG) and genistein (GN) in globin genes (<em>HBA1, HBB, HBG1</em> and <em>HBG2)</em> in HbF regulators/silencer genes (<em>KLF1, BCL11A, MYB</em> and <em>BGLT3)</em> and in epigenetic regulator genes (<em>DNMT1, DNMT3A, DNMT3B, HDAC1, HDAC2, HDAC3</em> and <em>HDAC8</em>)<em>.</em> Moreover, we evaluated EGCG’s <em>in vivo</em> effects in hematological parameters of healthy volunteers.</p></div><div><h3>Methods</h3><p>K562 cells were exposed for 72 and 96 h to GN and EGCG at 100, 250 and 500 ng/mL. Cell proliferation and viability were measured, and transcriptional levels were evaluated by qRT-PCR. For <em>in vivo</em> assay, complete blood count was determined by flow cytometry and HbF level was determined through HPLC in 30 healthy individuals before and after 225 mg EGCG ingestion per day during a 90-day period.</p></div><div><h3>Results</h3><p>Both compounds impact cellular metabolism and proliferation with no cytotoxic effects. Divergent GN and EGCG effects in globin and <em>BGLT3</em> expression levels suggest the involvement of divergent signaling pathways. As for the epigenetic potential, EGCG particularly affects <em>HDAC2</em> and <em>HDAC8</em> transcription, whereas GN significantly affects expression patterns of methylation and acetylation modulators. HU appears to have time divergent effects, with greater impact in methylation at 72 h (overregulates <em>DNTM3A</em>) while affecting acetylation mostly at 96 h (downregulates <em>HDAC1</em> and <em>HDAC8</em>). Additionally, <em>in vivo,</em> EGCG demonstrated a modulator effect in hematopoiesis and HbF induction.</p></div><div><h3>Conclusion</h3><p>Our results advocate EGCG and GN with HbF pharmacological reactivation potential and sustain further research as new alternative approaches for β-hemoglobinopathies therapies.</p></div>","PeriodicalId":72608,"journal":{"name":"Clinical complementary medicine and pharmacology","volume":"2 2","pages":"Article 100034"},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772371222000158/pdfft?md5=53d070631d0f96249055a890292d1008&pid=1-s2.0-S2772371222000158-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42651328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Traditional Chinese Medicine Constitution and Clinical Data Association with Machine Learning for Prediction of Spontaneous Abortion 中医体质和临床数据与机器学习预测自然流产的关联

Clinical complementary medicine and pharmacology

Pub Date : 2022-06-01 DOI: 10.1016/j.ccmp.2021.100016

Yan Liu , Yangyang Geng , Liuqing Yang , Shate Xiang , Qiaotong Wang , Lanyawen Hu , Ping Ye

Background

Early prevention of Spontaneous Abortion (SA) is essential for the treatment of recurrent spontaneous abortion.

Objective

In this retrospective study, a variety of machine learning methods were used to develop predictive models and diagnose the potential risk of SA.

Methods

A total of 663 pregnant women participated in the case-control study, 586 of which were SA patients and 77 were normal parturition women. The research data included 25 features of Traditional Chinese Medicine (TCM) constitution and clinical data related to SA. This work utilized 8 machine learning techniques including logistic regression, gradient boosting decision tree, k-nearest neighbor, classification and r-egression tree, multilayer perceptron, support vector machine, random forest and XG-Boost to predict SA. The performances of the applied models were evaluated by using the method of 10-fold cross-validation and by computing the diagnostic test characteristics, including accuracy, precision, recall, $F_{1}$ score, and the AUC of ROC curve.

Results

The $F_{1}$ scores of these eight machine learning techniques were all above 97.5%. Among them, gradient boosting decision tree had the best prediction result on SA. The accuracy, precision, recall, $F_{1}$ score, and the AUC of ROC curve of gradient boosting decision tree were 97.9%, 99%, 98.6%, 98.8%, and 97.3%, respectively.

Conclusion

The paper has accurately predicted the risk of SA combined with TCM constitution and clinical data.

背景:预防自然流产是治疗复发性自然流产的关键。目的在本回顾性研究中，采用多种机器学习方法建立预测模型并诊断SA的潜在风险。方法663例孕妇参与病例对照研究，其中SA患者586例，正常分娩妇女77例。研究数据包括25个中医体质特征和与SA相关的临床资料。本文利用逻辑回归、梯度增强决策树、k近邻、分类和r-回归树、多层感知器、支持向量机、随机森林和XG-Boost等8种机器学习技术来预测SA。采用10倍交叉验证的方法，通过计算诊断试验的准确度、精密度、召回率、F1评分和ROC曲线的AUC来评价所应用模型的性能。结果8种机器学习技术的F1得分均在97.5%以上。其中，梯度增强决策树对SA的预测效果最好。梯度增强决策树的准确率为97.9%，精密度为99%，召回率为98.6%，F1得分为98.8%，ROC曲线AUC为97.3%。结论结合中医体质和临床资料，准确预测了SA的发生风险。

{"title":"Traditional Chinese Medicine Constitution and Clinical Data Association with Machine Learning for Prediction of Spontaneous Abortion","authors":"Yan Liu , Yangyang Geng , Liuqing Yang , Shate Xiang , Qiaotong Wang , Lanyawen Hu , Ping Ye","doi":"10.1016/j.ccmp.2021.100016","DOIUrl":"10.1016/j.ccmp.2021.100016","url":null,"abstract":"<div><h3>Background</h3><p>Early prevention of Spontaneous Abortion (SA) is essential for the treatment of recurrent spontaneous abortion.</p></div><div><h3>Objective</h3><p>In this retrospective study, a variety of machine learning methods were used to develop predictive models and diagnose the potential risk of SA.</p></div><div><h3>Methods</h3><p>A total of 663 pregnant women participated in the case-control study, 586 of which were SA patients and 77 were normal parturition women. The research data included 25 features of Traditional Chinese Medicine (TCM) constitution and clinical data related to SA. This work utilized 8 machine learning techniques including logistic regression, gradient boosting decision tree, k-nearest neighbor, classification and r-egression tree, multilayer perceptron, support vector machine, random forest and XG-Boost to predict SA. The performances of the applied models were evaluated by using the method of 10-fold cross-validation and by computing the diagnostic test characteristics, including accuracy, precision, recall, <span><math><msub><mi>F</mi><mn>1</mn></msub></math></span> score, and the AUC of ROC curve.</p></div><div><h3>Results</h3><p>The <span><math><msub><mi>F</mi><mn>1</mn></msub></math></span> scores of these eight machine learning techniques were all above 97.5%. Among them, gradient boosting decision tree had the best prediction result on SA. The accuracy, precision, recall, <span><math><msub><mi>F</mi><mn>1</mn></msub></math></span> score, and the AUC of ROC curve of gradient boosting decision tree were 97.9%, 99%, 98.6%, 98.8%, and 97.3%, respectively.</p></div><div><h3>Conclusion</h3><p>The paper has accurately predicted the risk of SA combined with TCM constitution and clinical data.</p></div>","PeriodicalId":72608,"journal":{"name":"Clinical complementary medicine and pharmacology","volume":"2 2","pages":"Article 100016"},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772371221000164/pdfft?md5=d4ab712a1e67bf47d86b9212ea8cd90c&pid=1-s2.0-S2772371221000164-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41755009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Electroacupuncture Alleviates Anxiety-like Behavior in Pain Aversion Rats by Attenuating the Expression of Neuropeptide Y in Anterior Cingulate Cortex 电针通过降低前扣带皮层神经肽Y的表达来缓解疼痛厌恶大鼠焦虑样行为

Clinical complementary medicine and pharmacology

Pub Date : 2022-06-01 DOI: 10.1016/j.ccmp.2022.100019

Fangbing Shao , Junying Du , Sisi Wang , Rok Cerne , Junfan Fang , Xiaomei Shao , Xiaoming Jin , Jianqiao Fang

Background

Pain is considered as a multidimensional conscious experience that includes a sensory component and a negative affective-motivational component. Electroacupuncture (EA) is widely used to treat pain and pain-induced negative emotions, however, little is known about the mechanisms underlying the effect of EA.

Objective

This study investigated the effect of EA on alleviating the anxiety-like behaviors in pain aversion rats and its anterior cingulate cortex (ACC) regulation mechanism.

Methods

After a Freund's complete adjuvant (CFA)-conditioned place aversion (C-CPA) model was established in rats, EA treatment (2/100 Hz, 30 min, once/day, 4 days totally) was applied at bilateral Zusanli (ST36) and Kunlun (BL60) acupoints. Von Frey filaments were used to measure changes of pain withdrawal threshold (PWT) at indicated time points. Elevated zero maze (EZM) was used to investigate the changes of pain-related anxiety and CPA was used to investigate the changes of pain aversion. The protein expression levels of GAD67, PV, and NPY in ACC were detected by Western blotting.

Results

Compared with the control group, the staying time in the "CFA-paired compartment" was significantly reduced, and the PWT was decreased in model group. In the EZM assessment, the distance and the time in open arm, as well as the number of open arm entries of model group were significantly lower than those in the control group. In the CPA assessment, the time spent in the "CFA-paired compartment" was significantly decreased in model group compared with control group, and EA reversed the changes in pain sensation and in pain-related emotions. Western blotting showed that the NPY level, but not the levels of GAD67 and PV, was significantly increased in the ACC of the model group compared to that of the control group. The increased expression of NPY in the ACC was significantly downregulated by EA, while sham EA produced no such effect.

Conclusion

EA can effectively relieve the pain and pain-related emotions, and its mechanism may be achieved by down-regulating the expression of NPY in the ACC.

疼痛被认为是一种多维的意识体验，包括感官成分和消极的情感动机成分。电针(EA)被广泛用于治疗疼痛和疼痛引起的负性情绪，但其作用机制尚不清楚。目的探讨电针(EA)对疼痛厌恶大鼠焦虑样行为的缓解作用及其前扣带皮层(ACC)的调节机制。方法建立大鼠完全辅助(CFA)条件下的场所厌恶(C-CPA)模型后，在双侧足三里穴(ST36)和昆仑穴(BL60)分别施加EA (2/100 Hz, 30 min, 1次/天，共4 d)。采用Von Frey细丝测量疼痛戒断阈值(PWT)在指定时间点的变化。采用升高零迷宫(EZM)研究疼痛相关焦虑的变化，采用CPA研究疼痛厌恶的变化。Western blotting检测ACC组织中GAD67、PV、NPY蛋白表达水平。结果与对照组比较，模型组大鼠在“cfa配对室”中的停留时间明显减少，PWT明显降低。在EZM评估中，模型组大鼠开臂距离、开臂时间、开臂进入次数均显著低于对照组。在CPA评估中，与对照组相比，模型组在“cfa配对室”中的时间明显减少，EA逆转了疼痛感觉和疼痛相关情绪的变化。Western blotting结果显示，与对照组相比，模型组ACC中NPY水平明显升高，GAD67和PV水平未见明显升高。NPY在ACC中表达的增加被EA显著下调，而假EA则没有这种作用。结论ea能有效缓解疼痛及疼痛相关情绪，其机制可能是通过下调ACC中NPY的表达来实现的。

{"title":"Electroacupuncture Alleviates Anxiety-like Behavior in Pain Aversion Rats by Attenuating the Expression of Neuropeptide Y in Anterior Cingulate Cortex","authors":"Fangbing Shao , Junying Du , Sisi Wang , Rok Cerne , Junfan Fang , Xiaomei Shao , Xiaoming Jin , Jianqiao Fang","doi":"10.1016/j.ccmp.2022.100019","DOIUrl":"10.1016/j.ccmp.2022.100019","url":null,"abstract":"<div><h3>Background</h3><p>Pain is considered as a multidimensional conscious experience that includes a sensory component and a negative affective-motivational component. Electroacupuncture (EA) is widely used to treat pain and pain-induced negative emotions, however, little is known about the mechanisms underlying the effect of EA.</p></div><div><h3>Objective</h3><p>This study investigated the effect of EA on alleviating the anxiety-like behaviors in pain aversion rats and its anterior cingulate cortex (ACC) regulation mechanism.</p></div><div><h3>Methods</h3><p>After a Freund's complete adjuvant (CFA)-conditioned place aversion (C-CPA) model was established in rats, EA treatment (2/100 Hz, 30 min, once/day, 4 days totally) was applied at bilateral Zusanli (ST36) and Kunlun (BL60) acupoints. Von Frey filaments were used to measure changes of pain withdrawal threshold (PWT) at indicated time points. Elevated zero maze (EZM) was used to investigate the changes of pain-related anxiety and CPA was used to investigate the changes of pain aversion. The protein expression levels of GAD67, PV, and NPY in ACC were detected by Western blotting.</p></div><div><h3>Results</h3><p>Compared with the control group, the staying time in the \"CFA-paired compartment\" was significantly reduced, and the PWT was decreased in model group. In the EZM assessment, the distance and the time in open arm, as well as the number of open arm entries of model group were significantly lower than those in the control group. In the CPA assessment, the time spent in the \"CFA-paired compartment\" was significantly decreased in model group compared with control group, and EA reversed the changes in pain sensation and in pain-related emotions. Western blotting showed that the NPY level, but not the levels of GAD67 and PV, was significantly increased in the ACC of the model group compared to that of the control group. The increased expression of NPY in the ACC was significantly downregulated by EA, while sham EA produced no such effect.</p></div><div><h3>Conclusion</h3><p>EA can effectively relieve the pain and pain-related emotions, and its mechanism may be achieved by down-regulating the expression of NPY in the ACC.</p></div>","PeriodicalId":72608,"journal":{"name":"Clinical complementary medicine and pharmacology","volume":"2 2","pages":"Article 100019"},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772371222000018/pdfft?md5=a90dee5d003f849c9dcc7acba67e0879&pid=1-s2.0-S2772371222000018-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47226326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

METASTATIC LESION OF THE BRAIN. DIAGNOSIS AND TREATMENT 大脑的转移性病变。诊断与治疗

Clinical complementary medicine and pharmacology

Pub Date : 2022-05-24 DOI: 10.12737/2409-3750-2022-8-1-26-32

M. Bobkov

The article provides an overview of the current literature on the diagnosis and treatment of second-ary (metastatic) damage to the brain substance. Over the past years, Russia has seen a high incidence of malignant neoplasms, with a clearly observed upward trend. In 2019, this figure was 376.3 per 100,000 population compared to 369.6 per 100,000 population in 2018 and 293.7 per 100,000 population in 2000. However, thanks to modern methods of diagnosis and treatment, the life span of patients suffering from malignant neo-plasms is significantly increased, and, as a result, the chance of “surviving” before the onset of a metastatic lesion of the brain substance increases. Today, this formidable complication of the tumor process occurs in approximately 8-10% of cancer patients, while in most of them they are symptomatic. In some nosological forms of malig-nant neoplasms (small cell lung cancer, melanoma), the frequency of brain metastasis can reach 80% or more.

本文概述了目前关于脑物质二次(转移性)损伤的诊断和治疗的文献。在过去的几年里，俄罗斯的恶性肿瘤发病率很高，并且有明显的上升趋势。2019年，这一数字为每10万人376.3人，而2018年为每10万人369.6人，2000年为每10万人293.7人。然而，由于现代的诊断和治疗方法，患有恶性新质瘤的患者的寿命大大延长，因此，在脑物质转移病变发生之前“存活”的机会增加了。今天，这种可怕的肿瘤并发症发生在大约8-10%的癌症患者身上，而其中大多数是有症状的。在某些肿瘤学形式的恶性肿瘤(小细胞肺癌、黑色素瘤)中，脑转移的频率可达80%以上。

引用次数: 0

BREAST CANCER: general questions, clinic, diagnosis 乳腺癌:一般问题，临床，诊断

Clinical complementary medicine and pharmacology

Pub Date : 2022-05-24 DOI: 10.12737/2409-3750-2022-8-1-5-13

A. Guseynov, T. Guseynov, M. Bobkov, V. Blincov, V. Odincov

The lecture provides up-to-date information for doctors of various specialties: oncologists, surgeons, mammologists, general practitioners on breast cancer problems. The issues of etiology and pathogenesis, classification, clinic of breast tumors are highlighted, methods of modern diagnosis and differential diagnosis of breast cancer are described in detail.

讲座为不同专业的医生:肿瘤学家、外科医生、哺乳科医生、全科医生提供有关乳腺癌问题的最新信息。重点介绍了乳腺肿瘤的病因病机、分型、临床等问题，详细介绍了乳腺癌的现代诊断和鉴别诊断方法。

引用次数: 0

Therapeutic physical culture as a method of prevention of cardiovascular diseases 治疗性体育作为预防心血管疾病的一种方法

Clinical complementary medicine and pharmacology

Pub Date : 2022-05-24 DOI: 10.12737/2409-3750-2022-8-1-22-25

É. Asadova

The influence of physical culture on the health of the cardiovascular system (CCC) and the possibility of using physical therapy (exercise therapy) for the prevention of cardiovascular diseases (CVD) are considered. For the prevention of CCC diseases, physical education is recommended for everyone, but especially for people with risk factors. Various forms of classes can be used. Exercise therapy for CVD has a powerful positive effect on the patient's body, improves physical and mental condition, reduces the risk of many diseases and helps to recover from them, regulates the body, increases activity and efficiency.

体育对心血管系统(CCC)健康的影响和使用物理疗法(运动疗法)预防心血管疾病(CVD)的可能性。为了预防CCC疾病，建议每个人，特别是有危险因素的人进行体育锻炼。可以使用各种形式的类。心血管疾病的运动疗法对患者的身体有强大的积极作用，改善身体和精神状况，降低许多疾病的风险，并有助于从疾病中恢复，调节身体，增加活动和效率。

引用次数: 0

Dermatomyositis resistant to therapy: Demonstration of a clinical case. 耐药皮肌炎:一个临床病例的证明。

Clinical complementary medicine and pharmacology

Pub Date : 2022-05-24 DOI: 10.12737/2409-3750-2022-8-1-14-18

A. Fleyshman

Dermatomyositis is an autoimmune disease characterized by damage to proximal symmetrical muscle groups, skin in the form of erythema, as well as other systems. With timely diagnosis, dermatomyositis responds well to therapy with high doses of glucocorticosteroids. However, serious complications may develop during the course of the disease, for example, aspiration pneumonia, which significantly affect the patient's management tactics and the course of the disease. This article presents a clinical case of aspiration pneumonia on the background of dermatomyositis, which significantly limited the arsenal of therapy used.

皮肌炎是一种自身免疫性疾病，其特征是近端对称肌群、皮肤红斑以及其他系统受损。及时诊断，皮肌炎反应良好的治疗与高剂量的糖皮质激素。然而，在病程中可能出现严重的并发症，例如吸入性肺炎，严重影响患者的治疗策略和病程。这篇文章提出了一个临床病例吸入性肺炎的背景皮肌炎，这大大限制了武器库的治疗使用。

引用次数: 0

CLINICAL OBSERVATION OF STILL'S DISEASE still病的临床观察

Clinical complementary medicine and pharmacology

Pub Date : 2022-03-18 DOI: 10.12737/2409-3750-2022-7-4-22-27

A. Morozova

A clinical case of Still's disease in an 18-year-old girl who debuted with sore throat, lymphadenopathy, sore throat, febrile fever up to 39 ° C and maculopopular rash at its height is presented. The process of diagnosis, the appearance of symptoms over time and the diagnosis by exclusion is demonstrated.

一个临床病例斯蒂尔病在18岁的女孩谁首次出现喉咙痛，淋巴结病，喉咙痛，发热高达39°C和黄斑流行皮疹的高度提出。诊断的过程，随着时间的推移症状的出现和排除诊断被证明。

引用次数: 0

Goodpascher syndrome: a clinical case Goodpascher综合征临床一例

Clinical complementary medicine and pharmacology

Pub Date : 2022-03-18 DOI: 10.12737/2409-3750-2022-7-4-28-31

L. Zhuravleva

Goodpasture syndrome refers to systemic vasculitis with small-caliber vascular lesions, immunocomplex vasculitis. Immunocomplex vasculitis - vasculitis with moderate or pronounced deposits of immunoglobulins and/or complement components in the vascular wall, mainly small vessels (capillaries, venules, arterioles and small arteries). Glomerulonephritis is often observed. Diagnosis is difficult due to the rare frequency of the disease. The article presents a clinical case of Goodpascher syndrome.

Goodpasture综合征是指伴有小口径血管病变的全身性血管炎、免疫复杂性血管炎。免疫复合物血管炎——血管壁中有中度或明显的免疫球蛋白和/或补体成分沉积的血管炎，主要是小血管(毛细血管、小静脉、小动脉和小动脉)。常观察到肾小球肾炎。由于这种疾病罕见，诊断很困难。本文报告一例Goodpascher综合征的临床病例。

引用次数: 0

The problem of coexistence of the overlap syndrome and the neoplastic process on the example from clinical practice 以临床为例探讨重叠综合征与肿瘤过程共存的问题

Clinical complementary medicine and pharmacology

Pub Date : 2022-03-18 DOI: 10.12737/2409-3750-2022-7-4-17-21

O. Blashkevich

The publication considers a case of ovarian malignancy in a patient suffering from 11 years of overlap syndrome: a combination of progressive systemic sclerosis with dermatomyositis (antisynthetic syndrome). Timely recognition and treatment of cancer prevented an unfavorable outcome for this patient. At the same time, the termination of the basic anti-inflammatory therapy of systemic diseases (in this case, the cancellation of mycophenolate mofetil due to the lack of the drug in the pharmacy network of the city) led to a deterioration of the course of the disease, an aggravation of the clinical picture, which can create a so-called "vicious circle" of these pathologies.

该出版物考虑了一例卵巢恶性肿瘤患者患有11年的重叠综合征:进行性系统性硬化症与皮肌炎(抗合成综合征)的结合。及时的识别和治疗癌症避免了这名患者的不利结果。同时，终止全系统疾病的基本抗炎治疗(在这种情况下，由于城市药房网络中缺乏药物而取消霉酚酸酯)导致病程恶化，临床情况恶化，这可能会造成这些病理的所谓“恶性循环”。

引用次数: 0

首页上一页

类型

全部化学•材料生命科学医学物理工程技术环境•农林材料科学地球科学法学管理学化学环境科学与生态学计算机科学教育学经济学农林科学人文科学生物学数学物理与天体物理心理学综合性期刊其他工业工程理学历史学农学文学信息工程

数据库

全部 ACS Publications Elsevier ieeexplore Springer The Royal Society of Chemistry Wiley

期刊

Clinical complementary medicine and pharmacology

全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.

﹀