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Colocolic Fistula: A Rare Consequential Presentation of Cecal Mucinous Adenocarcinoma 结肠结肠瘘:盲肠黏液腺癌的罕见后遗症
Pub Date : 2023-11-27 DOI: 10.53785/2769-2779.1179
Jessica Rutyna, Paige A. Stratton, R. Sharma, Anthony V. Baratta
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引用次数: 0
Encephalopathy Tango: When Beta-Lactam Antibiotics Waltz with GABA Receptor 脑病探戈:当β -内酰胺抗生素与GABA受体华尔兹
Pub Date : 2023-08-14 DOI: 10.53785/2769-2779.1169
A. Mohamed, Nagesh Jadhav, M. Elbathani, Abubaker Farah
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引用次数: 0
Bi-Atrial Thrombus via Patent Foramen Ovale with Medical Noncompliance: A Case Report 经卵圆孔未闭的双房血栓不遵医嘱1例
Pub Date : 2023-08-14 DOI: 10.53785/2769-2779.1153
Reid McCullough, Ayesha Cheema, Owesh Contractor, Krystal Tomsky-Jackson
Numerous diagnoses in the hospital setting require anticoagulation. With different etiologies, certain specific assessments may not have a treatment plan that is studied extensively in evidence-based medical texts. In these uncommon situations, management may not have clear medical guidelines for successful treatment. We present a case of bi-atrial thrombus via PFO with concurrent pulmonary embolism, extensive clot burden history, and the plan to move forward with Angiovac. In patients with this specific history and pathology, modern procedures like Angiovac should be considered and discussed.
许多诊断在医院设置需要抗凝。对于不同的病因,某些特定的评估可能没有在循证医学文献中广泛研究的治疗计划。在这些不常见的情况下,管理层可能没有明确的医疗指导方针来成功治疗。我们报告了一个双房血栓经PFO并发肺栓塞的病例,广泛的凝块负担史,并计划继续使用Angiovac。对于有这种特殊病史和病理的患者,应该考虑和讨论现代手术,如Angiovac。
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引用次数: 0
Cystic Fibrosis - An Ever Evolving Challenge 囊性纤维化-一个不断演变的挑战
Pub Date : 2023-08-14 DOI: 10.53785/2769-2779.1160
A. Orakzai, Osama S. Khan, S. S. Raza, Muhammad H. Sharif, Mehr A. Orakzai
Abstract Cystic fibrosis (CF) is a genetic disease that results from mutations in a large single gene located on chromosome 7. More than 2000 different mutations in the gene have been identified to have caused the disease. Most of these mutations are exceedingly rare and therefore not a part of CF screening or all testing panels. This case discusses an adult female with a history of asthma, bronchiectasis, pseudomonas colonization, and respiratory failure on chronic oxygen who presented to the ED with sudden onset shortness of breath, fever, chills, body aches, nonproductive cough, and headache. The patient's condition clinically improved with treatment and was discharged on day three. The patient had previously undergone a laboratory evaluation of bronchiectasis. Due to the patient's history of bronchiectasis and pseudomonas colonization, there was a decision to reconsider the possibility of CF. The patient underwent a routine cystic fibrosis genetic testing panel which subsequently confirmed a CFTR mutation. The discussion highlights the importance of remaining vigilant for signs of CF, to remain open to the possibility of CF or CFTR related disorders, when patients have had evaluations for such that predate current testing standards or capabilities.
囊性纤维化(CF)是一种由位于7号染色体上的一个大单基因突变引起的遗传性疾病。超过2000种不同的基因突变已被确定为导致这种疾病的原因。大多数这些突变是非常罕见的,因此不是CF筛查或所有测试小组的一部分。本病例讨论了一名有哮喘、支气管扩张、假单胞菌定植和慢性吸氧呼吸衰竭病史的成年女性,她向急诊科表现为突然发作的呼吸短促、发烧、发冷、身体疼痛、非生产性咳嗽和头痛。经治疗,患者临床情况好转,于第3天出院。患者先前接受过支气管扩张的实验室评估。由于患者有支气管扩张史和假单胞菌定植史,我们决定重新考虑CF的可能性。患者接受了常规囊性纤维化基因检测,随后证实了CFTR突变。讨论强调了对CF迹象保持警惕的重要性,对CF或CFTR相关疾病的可能性保持开放的态度,当患者在目前的检测标准或能力之前进行了此类评估。
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引用次数: 0
Severe COVID-19 following Rituximab and Nirmatrelvir/ritonavir treatment in a patient with MCTD, Case Report 1例MCTD患者接受利妥昔单抗和尼马特韦/利托那韦治疗后出现严重COVID-19,病例报告
Pub Date : 2023-08-14 DOI: 10.53785/2769-2779.1154
Rohail A Baig, Faieja Chowdhury, Omar Siddiqui, Adnaan Sheikh, Varun Mehta, Pranjali Dakwale
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引用次数: 0
Non-Histaminergic Angioedema Following Infection with COVID-19 COVID-19感染后的非组胺性血管性水肿
Pub Date : 2023-08-14 DOI: 10.53785/2769-2779.1168
Sheza Malik, Basil George Verghese, S Shahzad Mustafa
Non-respiratory manifestations of COVID-19, including dermatological manifestations, have been reported, and although urticaria associated with COVID-19 has been reported, there have been no reports of non-histaminergic angioedema following infection with mild COVID-19. Non-histaminergic angioedema has a gradual onset and is characterized by submucosal swelling without accompanying urticaria or pruritus, and poor response to antihistamines and corticosteroids. We report a case of non-histaminergic angioedema in a 29-year-old woman with a history of mild COVID-19 infection. Our case highlights the fact that early diagnosis of non-histaminergic angioedema in mild COVID-19 patients is crucial for effective treatment and requires a high level of suspicion from both general and emergency physicians.
已报道了COVID-19的非呼吸道表现,包括皮肤表现,尽管已报道了与COVID-19相关的荨麻疹,但尚未报道轻度COVID-19感染后出现非组胺能性血管性水肿。非组胺能性血管性水肿发病缓慢,特征为粘膜下肿胀,不伴有荨麻疹或瘙痒,对抗组胺药和皮质类固醇反应差。我们报告一例29岁女性非组胺能性血管性水肿,有轻度COVID-19感染史。我们的病例强调了这样一个事实,即轻度COVID-19患者的非组胺能性血管性水肿的早期诊断对于有效治疗至关重要,需要普通医生和急诊医生的高度怀疑。
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引用次数: 0
Persistent Foci of Infection: A Case of Two Mycotic Aneurysms Separated in Time in A Patient with Infective E. Faecalis Endocarditis 持续性病灶感染:感染性粪肠杆菌心内膜炎患者及时分离两个真菌性动脉瘤1例
Pub Date : 2023-08-14 DOI: 10.53785/2769-2779.1166
Julia C. Stone, Joel C. Thompson, J. Hatem, Evan Basha
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引用次数: 0
Hydroxychloroquine Induced Cardiomyopathy 羟氯喹致心肌病
Pub Date : 2023-08-14 DOI: 10.53785/2769-2779.1165
Mohamed Salah Mohamed, Katrina Wojciechowski, Scott Feitell, Muhammad Osama, Anas Hashem, Jayesh Patel, Amir-Ali Mahmoud, A. Abdelhay, Prakash Upreti, S. Khodjaev
Abstract Hydroxychloroquine (HCQ) is one of the immunomodulatory medications used in treatment of autoimmune diseases. Rarely, HCQ can cause serious complications, such as cardiotoxicity. We present a rare case of HCQ-induced cardiomyopathy. 60-year-old female patient with a medical history of SLE on chronic HCQ therapy for 28 years, preexisting non-ischemic cardiomyopathy and heart failure with reduced ejection fraction for 7 years, and complete heart block status post pacemaker insertion presented with acute chest pain and severe weight loss. Patient underwent coronary angiogram that showed normal coronaries and right-sided heart catheterization that showed acute heart failure. Echocardiogram showed LVEF of 30% with global hypokinesis. Patient was started on dobutamine with an improvement of her symptoms. As HCQ-induced cardiomyopathy was suspected, patient underwent an endomyocardial biopsy that revealed a pathognomonic finding of myocyte vacuolization, consistent with HCQ-induced cardiomyopathy. HCQ was discontinued immediately. However, patient was a poor candidate for heart transplantation and durable mechanical circulatory support due to severe malnutrition secondary to end-stage heart failure. Patient accepted hospice care and passed away peacefully. This case highlights the need for high index of clinical suspicion, careful medication reconciliation for patients with non-ischemic cardiomyopathy, and tissue biopsy with careful histopathological examination to diagnose this rare complication.
摘要羟氯喹(Hydroxychloroquine, HCQ)是一种用于治疗自身免疫性疾病的免疫调节药物。很少,HCQ会引起严重的并发症,如心脏毒性。我们报告一例罕见的hcq引起的心肌病。60岁女性,慢性HCQ治疗SLE病史28年,既往存在非缺血性心肌病、心力衰竭伴射血分数降低7年,植入起搏器后处于完全心脏传导阻滞状态,急性胸痛,体重严重下降。患者行冠状动脉造影显示冠状动脉正常,右侧心导管检查显示急性心力衰竭。超声心动图显示LVEF 30%,全身运动不足。病人开始服用多巴酚丁胺症状有所改善由于怀疑hcq诱导的心肌病,患者进行了心内膜活检,发现心肌细胞空泡化,与hcq诱导的心肌病一致。HCQ立即停产。然而,由于严重的营养不良继发于终末期心力衰竭,患者不适合心脏移植和持久的机械循环支持。病人接受了临终关怀,平静地离开了人世。本病例强调需要高度的临床怀疑,对非缺血性心肌病患者进行仔细的药物调节,并进行组织活检和仔细的组织病理学检查来诊断这种罕见的并发症。
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引用次数: 0
Median Arcuate Ligament Syndrome: A Rare Cause of Abdominal Pain That is Difficult to Identify 正中弓状韧带综合征:一种罕见的腹痛原因,很难确定
Pub Date : 2023-08-14 DOI: 10.53785/2769-2779.1167
Mark E Eskander, Matthew Thrall, Joel P Thompson
Median arcuate ligament syndrome (MALS) is a rare disease that occurs when the celiac artery is compressed by the median arcuate ligament. Patients with MALS typically present with non-specific symptoms that overlap with more common diseases. As a result, patients may undergo extensive workup and unnecessary treatments before being properly diagnosed with MALS. In this case we present a 23-year-old female with chronic postprandial abdominal pain that persisted despite undergoing a cholecystectomy. This case highlights the symptoms and imaging findings needed to diagnose MALS and thus prevent unnecessary surgical interventions.
中弓韧带综合征(MALS)是一种罕见的疾病,发生在腹腔动脉被中弓韧带压迫。肌萎缩侧索硬化症患者通常表现出与更常见疾病重叠的非特异性症状。因此,在被正确诊断为肌萎缩侧索硬化症之前,患者可能会经历大量的检查和不必要的治疗。在这个病例中,我们报告了一位23岁的女性,她患有慢性餐后腹痛,尽管接受了胆囊切除术,但仍持续存在。本病例强调了诊断肌萎缩侧索硬化症所需的症状和影像学表现,从而防止不必要的手术干预。
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引用次数: 0
Court Decisions Demonstrate Need for Public Health Economy: A Position Statement of Public Health Liberation 法院判决证明需要公共卫生经济:公共卫生解放的立场声明
Pub Date : 2023-08-14 DOI: 10.53785/2769-2779.1184
Christopher Williams, Public Health Liberation Board of Directors
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引用次数: 0
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Advances in Clinical Medical Research and Healthcare Delivery
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