Here we present a rare case of infective endocarditis (IE) with Streptococcus canis and Chiari network in an 85 year old female living with multiple dogs and open skin of lower extremity predisposing her to bacteremia. Underlying abnormalities of the cardiac chambers such as Chiari network predisposes to a higher incidence of bacterial seeding and causing IE. A Chiari network is usually asymptomatic and of no clinical significance but can worsen prognosis in IE. IE carries a significant morbidity and mortality burden and when diagnosed early can be a lifesaving diagnosis. Due to the wide range of complications, early diagnosis and treatment with targeted antimicrobial therapy and consideration of early surgical intervention are vital to the evaluation and treatment of IE. Though Staphylococci, Streptococci, Enterococci, HACEK organisms amount for the majority of IE, some atypical organisms including group G Streptococci such as S. canis have been reported to carry high mortality and hospitalization risk in patients with bacteremia. S. canis is a group G beta-hemolytic Streptococci which normally resides on the skin and mucosal surfaces of dogs. This Case Report shines light on the versatility of microorganisms that can cause IE in a patient with underling Chiari network, and the risk of morbidity and mortality with such species highlighting the importance of early diagnosis and treatment.
{"title":"Case Study: Abnormal Presentation of Infective Endocarditis With Streptococcus Canis and Chiari Network","authors":"Shahbaz Afzal, Ryan F. Russell, A. Chekhov","doi":"10.53785/2769-2779.1111","DOIUrl":"https://doi.org/10.53785/2769-2779.1111","url":null,"abstract":"Here we present a rare case of infective endocarditis (IE) with Streptococcus canis and Chiari network in an 85 year old female living with multiple dogs and open skin of lower extremity predisposing her to bacteremia. Underlying abnormalities of the cardiac chambers such as Chiari network predisposes to a higher incidence of bacterial seeding and causing IE. A Chiari network is usually asymptomatic and of no clinical significance but can worsen prognosis in IE. IE carries a significant morbidity and mortality burden and when diagnosed early can be a lifesaving diagnosis. Due to the wide range of complications, early diagnosis and treatment with targeted antimicrobial therapy and consideration of early surgical intervention are vital to the evaluation and treatment of IE. Though Staphylococci, Streptococci, Enterococci, HACEK organisms amount for the majority of IE, some atypical organisms including group G Streptococci such as S. canis have been reported to carry high mortality and hospitalization risk in patients with bacteremia. S. canis is a group G beta-hemolytic Streptococci which normally resides on the skin and mucosal surfaces of dogs. This Case Report shines light on the versatility of microorganisms that can cause IE in a patient with underling Chiari network, and the risk of morbidity and mortality with such species highlighting the importance of early diagnosis and treatment.","PeriodicalId":7266,"journal":{"name":"Advances in Clinical Medical Research and Healthcare Delivery","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86551619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Ashour, Sundus Nasim, Hallas Kadhim, Maan Faraj, Sylvia E Eshak
Testicular cancer is a curable oncologic disease of males mostly aged 15-44 years. Most of the patients are successfully treated with radical orchiectomy. However, a delayed presentation may lead to a dismal prognosis. There are several risk factors including cryptorchidism, a first-degree relative with testicular cancer, hypospadias, childhood inguinal hernia, and military pollutant exposure, among others. The distant metastasis of testicular carcinoma to the lung, liver, and brain are widely described. We present a unique case of a 28-year-old male who presented with gastrointestinal (GI) bleeding. Later, it was discovered that he had a metastatic testicular carcinoma synchronous with an oral squamous cell carcinoma. Metastasis was detected by imaging including X-ray, computerized tomography (CT) of the chest, abdomen, and brain magnetic resonance imaging (MRI). The presence of two primary cancers concurrently is rare and indicates a poor prognosis. Because of the absence of risk factors in this patient, he was thought to be potentially exposed to depleted uranium from warfare due to his residence in Iraq. Markedly raised beta-human chorionic gonadotropin (b-HCG) titers indicate a possible nonseminomatous type; however, the exact type is unknown as the patient declined fine needle aspiration (FNA)/biopsy and orchiectomy. This case focuses on the atypical presentation and the importance of when to seek medical attention, as a delayed presentation can lead to a poor prognosis. Moreover, it heightens awareness that other malignancies may occur concurrently. As well as to emphasize on means that can be used to educate high-risk groups.
{"title":"Metastatic Testicular Cancer Patient with Synchronous Oral Squamous Cell Carcinoma Presented with Gastrointestinal Bleeding: A Case Report","authors":"M. Ashour, Sundus Nasim, Hallas Kadhim, Maan Faraj, Sylvia E Eshak","doi":"10.53785/2769-2779.1112","DOIUrl":"https://doi.org/10.53785/2769-2779.1112","url":null,"abstract":"Testicular cancer is a curable oncologic disease of males mostly aged 15-44 years. Most of the patients are successfully treated with radical orchiectomy. However, a delayed presentation may lead to a dismal prognosis. There are several risk factors including cryptorchidism, a first-degree relative with testicular cancer, hypospadias, childhood inguinal hernia, and military pollutant exposure, among others. The distant metastasis of testicular carcinoma to the lung, liver, and brain are widely described. We present a unique case of a 28-year-old male who presented with gastrointestinal (GI) bleeding. Later, it was discovered that he had a metastatic testicular carcinoma synchronous with an oral squamous cell carcinoma. Metastasis was detected by imaging including X-ray, computerized tomography (CT) of the chest, abdomen, and brain magnetic resonance imaging (MRI). The presence of two primary cancers concurrently is rare and indicates a poor prognosis. Because of the absence of risk factors in this patient, he was thought to be potentially exposed to depleted uranium from warfare due to his residence in Iraq. Markedly raised beta-human chorionic gonadotropin (b-HCG) titers indicate a possible nonseminomatous type; however, the exact type is unknown as the patient declined fine needle aspiration (FNA)/biopsy and orchiectomy. This case focuses on the atypical presentation and the importance of when to seek medical attention, as a delayed presentation can lead to a poor prognosis. Moreover, it heightens awareness that other malignancies may occur concurrently. As well as to emphasize on means that can be used to educate high-risk groups.","PeriodicalId":7266,"journal":{"name":"Advances in Clinical Medical Research and Healthcare Delivery","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84276502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Staphylococcal toxic shock syndrome (STSS) is characterized by acute, progressive illness with fever, rapid-onset hypotension, and multisystem organ failure. The clinical course of STSS is attributable to host response to exotoxins with superantigenic properties. Fulminant staphylococcal infection is often associated with a deep focus of infection. In this report, we present a 10-year-old boy with multisystem organ failure as a result of STSS, a rare fatal complication following soft tissue injury. The rapid and fulminant progression of the disease in our patient precluded early timely diagnosis of STSS that may have allowed for the initiation of life-saving supportive intervention. Furthermore, the rapidly developing STSS occurred without an identifiable infectious source. The diagnosis of STSS was made upon the sum total of the clinical presentation, laboratory and autopsy findings, and antemortem and postmortem microbiology studies. It is crucial for health care providers to be aware of the possibility of STSS, even in the absence of overt focal infections and risk factors. A high index of suspicion for STSS should be present in critically ill patients presenting with a precipitous course of sepsis, septic shock, or systemic inflammatory response syndrome (SIRS).
{"title":"A Rare Presentation of Fulminant Toxic Shock Syndrome in a Healthy 10-Year-Old Male Patient","authors":"A. Sabirov, M. Caplan","doi":"10.53785/2769-2779.1128","DOIUrl":"https://doi.org/10.53785/2769-2779.1128","url":null,"abstract":"Staphylococcal toxic shock syndrome (STSS) is characterized by acute, progressive illness with fever, rapid-onset hypotension, and multisystem organ failure. The clinical course of STSS is attributable to host response to exotoxins with superantigenic properties. Fulminant staphylococcal infection is often associated with a deep focus of infection. In this report, we present a 10-year-old boy with multisystem organ failure as a result of STSS, a rare fatal complication following soft tissue injury. The rapid and fulminant progression of the disease in our patient precluded early timely diagnosis of STSS that may have allowed for the initiation of life-saving supportive intervention. Furthermore, the rapidly developing STSS occurred without an identifiable infectious source. The diagnosis of STSS was made upon the sum total of the clinical presentation, laboratory and autopsy findings, and antemortem and postmortem microbiology studies. It is crucial for health care providers to be aware of the possibility of STSS, even in the absence of overt focal infections and risk factors. A high index of suspicion for STSS should be present in critically ill patients presenting with a precipitous course of sepsis, septic shock, or systemic inflammatory response syndrome (SIRS).","PeriodicalId":7266,"journal":{"name":"Advances in Clinical Medical Research and Healthcare Delivery","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84344983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jay Bapaye, Ahmed Shehadah, Chengu Niu, Anas Hashem, R. Sharma, Patrick Okolo
Abstract Pancreatic duct (PD) stenting is a common treatment modality for PD calculi or strictures, which are common complications of chronic pancreatitis. PD stent migration is a described complication of the procedure. Penetrating splenic injury may result in life-threatening hemorrhage, often requiring splenic artery embolization or splenectomy. Herein, we describe a unique case of a 49- year-old female with chronic pancreatitis and PD stent who presented with abdominal pain. A computed tomography of her abdomen revealed the distal end of her PD stent to have migrated internally through her spleen with an associated perisplenic fluid collection. After initial clinical stabilization she underwent an endoscopic retrograde cholangiopancreatography which revealed the proximal end of the migrated stent in the duodenum and the stent was successfully with improvement in clinical status.
{"title":"An Invading Stent: Conservative Management of a Penetrating Splenic Injury by a Migrated Pancreatic Duct Stent","authors":"Jay Bapaye, Ahmed Shehadah, Chengu Niu, Anas Hashem, R. Sharma, Patrick Okolo","doi":"10.53785/2769-2779.1131","DOIUrl":"https://doi.org/10.53785/2769-2779.1131","url":null,"abstract":"Abstract Pancreatic duct (PD) stenting is a common treatment modality for PD calculi or strictures, which are common complications of chronic pancreatitis. PD stent migration is a described complication of the procedure. Penetrating splenic injury may result in life-threatening hemorrhage, often requiring splenic artery embolization or splenectomy. Herein, we describe a unique case of a 49- year-old female with chronic pancreatitis and PD stent who presented with abdominal pain. A computed tomography of her abdomen revealed the distal end of her PD stent to have migrated internally through her spleen with an associated perisplenic fluid collection. After initial clinical stabilization she underwent an endoscopic retrograde cholangiopancreatography which revealed the proximal end of the migrated stent in the duodenum and the stent was successfully with improvement in clinical status.","PeriodicalId":7266,"journal":{"name":"Advances in Clinical Medical Research and Healthcare Delivery","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75544471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mukul Singal, S. Kashinath, S. Mustafa, Edward Walsh, K. Vadamalai, Saad Jamshed
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the current COVID-19 pandemic. There is emerging evidence regarding suboptimal response to vaccination against COVID-19 in patients with hematologic and solid organ malignancies. We conducted a single-center prospective study assessing seroconversion in response to vaccination against COVID-19 in 53 patients with chronic lymphocytic leukemia (CLL), non-Hodgkin’s lymphoma (NHL), multiple myeloma (MM), and solid organ malignancies. A quantitative immunoassay of IgG antibodies to SARS-CoV-2 Spike (S) protein was measured prior to vaccination and at 2 weeks after completion of two-dose vaccination series. A fourfold increase in antibody titers was considered positive seroconversion. Through a predesigned survey, patients also selfreported side effects from each dose of vaccination. Seroconversion on vaccination was seen in 6/12 (50%) patients with CLL, 7/11 (63.6%) patients with NHL, 9/10 (90%) patients with MM, and 17/20 (85%) patients with solid organ malignancy. Only 6 of the 14 (42.8%) patients currently on or with previous history of rituximab use seroconverted. Injection site soreness was the most reported side effect. The only severe side effect occurred in a patient with solid organ malignancy who developed Parsonage-Turner syndrome. Patients with CLL and NHL appear less likely to respond to vaccination against COVID-19 in contrast to patients with MM or solid organ malignancies. Previous treatment with rituximab is a possible risk factor for suboptimal response to vaccination. These data highlight the importance of continuing risk mitigation strategies against COVID-19 in individuals with hematologic malignancy, particularly those with CLL or on treatment with rituximab.
{"title":"Evaluation Of Antibody Response To Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Vaccination In Patients With Lymphoid And Solid Organ Malignancies","authors":"Mukul Singal, S. Kashinath, S. Mustafa, Edward Walsh, K. Vadamalai, Saad Jamshed","doi":"10.53785/2769-2779.1118","DOIUrl":"https://doi.org/10.53785/2769-2779.1118","url":null,"abstract":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the current COVID-19 pandemic. There is emerging evidence regarding suboptimal response to vaccination against COVID-19 in patients with hematologic and solid organ malignancies. We conducted a single-center prospective study assessing seroconversion in response to vaccination against COVID-19 in 53 patients with chronic lymphocytic leukemia (CLL), non-Hodgkin’s lymphoma (NHL), multiple myeloma (MM), and solid organ malignancies. A quantitative immunoassay of IgG antibodies to SARS-CoV-2 Spike (S) protein was measured prior to vaccination and at 2 weeks after completion of two-dose vaccination series. A fourfold increase in antibody titers was considered positive seroconversion. Through a predesigned survey, patients also selfreported side effects from each dose of vaccination. Seroconversion on vaccination was seen in 6/12 (50%) patients with CLL, 7/11 (63.6%) patients with NHL, 9/10 (90%) patients with MM, and 17/20 (85%) patients with solid organ malignancy. Only 6 of the 14 (42.8%) patients currently on or with previous history of rituximab use seroconverted. Injection site soreness was the most reported side effect. The only severe side effect occurred in a patient with solid organ malignancy who developed Parsonage-Turner syndrome. Patients with CLL and NHL appear less likely to respond to vaccination against COVID-19 in contrast to patients with MM or solid organ malignancies. Previous treatment with rituximab is a possible risk factor for suboptimal response to vaccination. These data highlight the importance of continuing risk mitigation strategies against COVID-19 in individuals with hematologic malignancy, particularly those with CLL or on treatment with rituximab.","PeriodicalId":7266,"journal":{"name":"Advances in Clinical Medical Research and Healthcare Delivery","volume":"44 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74117646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Amanda Kostryk, Ravi Patel, JulieAnn Warner, Joel Thompson
Abstract Multidisciplinary tumor boards (MDTBs) provide a venue for discussion of diagnosis, staging, and treatment of patients with cancer. MDTBs have been shown to improve diagnostic accuracy and staging, exemplified in this patient with a hepatic flexure mass on colonoscopy and initial pathology suggestive of primary colonic adenocarcinoma with surface mucosal involvement. However, subsequent CT imaging revealed a biliary malignancy invading the colon. Discussion at a MDTB facilitated radiology-pathology correlation, with subsequent immunohistochemical stains compatible with a cholangiocarcinoma with transmural colonic invasion. Prompt and accurate diagnosis after the MDTB enabled the oncology team to offer the proper treatment approach.
{"title":"Accurate Diagnosis After Multidisciplinary Tumor Board: A Case Report of Cholangiocarcinoma","authors":"Amanda Kostryk, Ravi Patel, JulieAnn Warner, Joel Thompson","doi":"10.53785/2769-2779.1132","DOIUrl":"https://doi.org/10.53785/2769-2779.1132","url":null,"abstract":"Abstract Multidisciplinary tumor boards (MDTBs) provide a venue for discussion of diagnosis, staging, and treatment of patients with cancer. MDTBs have been shown to improve diagnostic accuracy and staging, exemplified in this patient with a hepatic flexure mass on colonoscopy and initial pathology suggestive of primary colonic adenocarcinoma with surface mucosal involvement. However, subsequent CT imaging revealed a biliary malignancy invading the colon. Discussion at a MDTB facilitated radiology-pathology correlation, with subsequent immunohistochemical stains compatible with a cholangiocarcinoma with transmural colonic invasion. Prompt and accurate diagnosis after the MDTB enabled the oncology team to offer the proper treatment approach.","PeriodicalId":7266,"journal":{"name":"Advances in Clinical Medical Research and Healthcare Delivery","volume":"71 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77969613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The purpose of our study was to study the nature of clinical manifestations and risk factors for the development of bronchial asthma (BA) in children. We examined 120 children aged 5 to 15 years with asthma who were on inpatient treatment in the department of pulmonology and allergology. With moderate and severe asthma, there was a longer manifestation of shortness of breath, oral wheezing, wet cough and wet wheezing in the lungs, emphysematous lung enlargement on both sides with horizontal standing of the ribs. In the presence of severe bronchospasm, the symptoms of intoxication and respiratory failure were more pronounced, which is manifested by long-term clinical signs of the disease. Among the main risk factors for the development of AD, hereditary burden, peculiarities of maternal nutrition during pregnancy and lactation, early transfer of the child to mixed and artificial feeding, unfavorable course of the peri–, intranatal periods and comorbid background can be distinguished.
{"title":"Modern Aspects of Risk Factors for the Formation of Bronchial Asthma in Children","authors":"Furkat Mukhitdinovich Shamsiev, Nilufarkhon Karimova, Zamirahon Olimjonovna Urumboeva","doi":"10.48112/acmr.v3i3.38","DOIUrl":"https://doi.org/10.48112/acmr.v3i3.38","url":null,"abstract":"The purpose of our study was to study the nature of clinical manifestations and risk factors for the development of bronchial asthma (BA) in children. We examined 120 children aged 5 to 15 years with asthma who were on inpatient treatment in the department of pulmonology and allergology. With moderate and severe asthma, there was a longer manifestation of shortness of breath, oral wheezing, wet cough and wet wheezing in the lungs, emphysematous lung enlargement on both sides with horizontal standing of the ribs. In the presence of severe bronchospasm, the symptoms of intoxication and respiratory failure were more pronounced, which is manifested by long-term clinical signs of the disease. Among the main risk factors for the development of AD, hereditary burden, peculiarities of maternal nutrition during pregnancy and lactation, early transfer of the child to mixed and artificial feeding, unfavorable course of the peri–, intranatal periods and comorbid background can be distinguished.","PeriodicalId":7266,"journal":{"name":"Advances in Clinical Medical Research and Healthcare Delivery","volume":"49 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82692865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This article presents information about the relationship of habitual miscarriage with endocrine pathology. Endocrine factors in 75% of cases are the cause of complicated pregnancy up to 20 weeks. Untimely and inadequate therapy of complications of early pregnancy leads to termination of pregnancy not only in the first trimester, but also in later gestation.
{"title":"Habitual Miscarriage of Pregnancy with Endocrine Disorders","authors":"Mukhammedaminova Diyora Timurovna, Nasyrova Khurshidakhon Kudratullayevna","doi":"10.48112/acmr.v3i3.36","DOIUrl":"https://doi.org/10.48112/acmr.v3i3.36","url":null,"abstract":"This article presents information about the relationship of habitual miscarriage with endocrine pathology. Endocrine factors in 75% of cases are the cause of complicated pregnancy up to 20 weeks. Untimely and inadequate therapy of complications of early pregnancy leads to termination of pregnancy not only in the first trimester, but also in later gestation.","PeriodicalId":7266,"journal":{"name":"Advances in Clinical Medical Research and Healthcare Delivery","volume":"98 2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87710950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The aim of the study was to develop methods for the prevention of prolonged community-acquired pneumonia in children. 180 children aged 6 months to 15 years with community-acquired pneumonia of a prolonged course, who are being treated in the department of pulmonology, were examined. Analysis of anamnestic data showed that all children, regardless of the development of the disease, had repeatedly suffered acute respiratory infections, pneumonia, intestinal infections, purulent-septic diseases, characterized by a long, recurrent course and difficult to respond to antimicrobial therapy.
{"title":"Modern Possibilities of Immunoprophylaxis of Prolonged Course of Community-Acquired Pneumonia in Children","authors":"Furkat Mukhitdinovich Shamsiev, Nilufarkhon Karimova, Safura Nosirjonovna Zaynabitdinova","doi":"10.48112/acmr.v3i3.37","DOIUrl":"https://doi.org/10.48112/acmr.v3i3.37","url":null,"abstract":"The aim of the study was to develop methods for the prevention of prolonged community-acquired pneumonia in children. 180 children aged 6 months to 15 years with community-acquired pneumonia of a prolonged course, who are being treated in the department of pulmonology, were examined. Analysis of anamnestic data showed that all children, regardless of the development of the disease, had repeatedly suffered acute respiratory infections, pneumonia, intestinal infections, purulent-septic diseases, characterized by a long, recurrent course and difficult to respond to antimicrobial therapy.","PeriodicalId":7266,"journal":{"name":"Advances in Clinical Medical Research and Healthcare Delivery","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81711635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The aim of our study was to study the indicators of cytokine status and to determine the features of the hemostasis system and the acid-base state in children with bronchial asthma. We examined 25 children with bronchial asthma aged 7 to 14 years. The study program included: the determination of the level of cytokines: IL-1β and IL-8, the determination of the activity of the acid-base state of the blood. The results of the study showed that the development of bronchial asthma is facilitated by the unfavorable course of the peri- and intranatal periods, aggravated premorbid background, concomitant and past diseases, and significantly high levels of pro-inflammatory cytokines IL-1β and IL-8 were revealed. From the side of biochemical indicators, a very low level of prothrombin time, mild metabolic alkalosis, low partial pressure of oxygen in the blood, and a decrease in the concentration of potassium and calcium ions were detected.
{"title":"Immunological and Biochemical Features in Bronchial Asthma in Children","authors":"Furkat Mukhitdinovich Shamsiev, Nilufarkhon Karimova","doi":"10.48112/acmr.v3i3.39","DOIUrl":"https://doi.org/10.48112/acmr.v3i3.39","url":null,"abstract":"The aim of our study was to study the indicators of cytokine status and to determine the features of the hemostasis system and the acid-base state in children with bronchial asthma. We examined 25 children with bronchial asthma aged 7 to 14 years. The study program included: the determination of the level of cytokines: IL-1β and IL-8, the determination of the activity of the acid-base state of the blood. The results of the study showed that the development of bronchial asthma is facilitated by the unfavorable course of the peri- and intranatal periods, aggravated premorbid background, concomitant and past diseases, and significantly high levels of pro-inflammatory cytokines IL-1β and IL-8 were revealed. From the side of biochemical indicators, a very low level of prothrombin time, mild metabolic alkalosis, low partial pressure of oxygen in the blood, and a decrease in the concentration of potassium and calcium ions were detected.","PeriodicalId":7266,"journal":{"name":"Advances in Clinical Medical Research and Healthcare Delivery","volume":"71 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84487255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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