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Evaluation of skills in swing technique in classical Japanese swordsmanship using sensors. 用传感器评价日本古典剑术中挥击技巧。
S. Okamoto
In this study, we analyzed the swing motions of more experienced practitioner and new practitioner of iaido players by using tri-axial acceleration sensor and gyro sensor. Iaido is a modern Japanese martial art/sport. In this way, the acceleration and gyro sensor measurement enabled detailed motion information at the installation points to be displayed in a short time, thus making it possible to easily extract the objective problems. Although it was not possible to confirm by the acceleration and angular velocity measurements the detailed motion of the entire body as obtained in the 2D motion analysis with a high-speed camera, it was confirmed that the acceleration and gyro sensor is an evaluation means that can be installed easily and can provide the exercise information in a short time as an objective index.
本研究采用三轴加速度传感器和陀螺传感器,分析了相扑练习者的挥拍动作。相合道是一种现代日本武术/运动。这样,通过加速度和陀螺仪传感器的测量,可以在短时间内显示安装点的详细运动信息,从而可以方便地提取客观问题。虽然不能像高速摄像机在二维运动分析中得到的那样,通过加速度和角速度的测量来确定整个身体的详细运动,但可以确定加速度和陀螺传感器是一种易于安装、可以在短时间内提供运动信息的客观指标的评价手段。
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引用次数: 0
Identifying important regions in EEG epilepsy brain networks. 识别脑电图癫痫脑网络的重要区域。
Nantia D. Iakovidou, Manolis Christodoulakis, E. Papathanasiou, S. Papacostas, G. Mitsis
The human brain has been called the most complex object in the known universe and in many ways it constitutes the final frontier of science. Lately, the functional connectivity in human brain has been regarded and studied as a complex network using electroencephalography (EEG) signals. This means that the brain is studied as a connected system, where nodes represent different specialized brain regions and links or connections, represent communication pathways between the nodes. It is also fairly established that graph theory provides a variety of measures, methods and tools that can be useful to efficiently model, analyze and study an EEG network. In this article we study weighted and fully-connected brain networks, created from long-recorded EEG measurements that concern patients with focal and generalized epilepsy. We focus on the use of the well-known eigenvector centrality measure, which shows the influence of a node in a network and also constitutes the basis of the famous Google's PageRank algorithm. Our novel methodology reveals brain regions that might play a significant role before the occurrence of each epileptic seizure and also brain areas that might constitute the seed of the abnormal electrical activity that the human brain presents during epileptic seizures. Finally, we present and discuss the results and conclusions of our methodology, which demonstrates a standard EEG behavior in particular phases of the recording period.
人脑被称为已知宇宙中最复杂的物体,在许多方面,它构成了科学的最后前沿。近年来,人们利用脑电图(EEG)信号将人脑的功能连接视为一个复杂的网络进行研究。这意味着大脑是作为一个连接的系统来研究的,其中节点代表不同的专门的大脑区域,链接或连接代表节点之间的通信途径。图论提供了多种有效建模、分析和研究脑电图网络的方法、方法和工具。在本文中,我们研究加权和全连接的大脑网络,从长期记录的脑电图测量中创建,涉及局灶性和全面性癫痫患者。我们专注于使用著名的特征向量中心性度量,它显示了网络中节点的影响,也构成了著名的Google的PageRank算法的基础。我们的新方法揭示了可能在每次癫痫发作发生前发挥重要作用的大脑区域,以及可能构成癫痫发作期间人类大脑异常电活动种子的大脑区域。最后,我们提出并讨论了我们的方法的结果和结论,它展示了在记录期间的特定阶段的标准脑电图行为。
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引用次数: 0
Characterization of motor cortex activity of the lower limb region. 下肢运动皮质活动的表征。
Fadi Mikhail, K. Balasubramanian, Matthew D. Best, Kazutaka Takahashi, N. Hatsopoulos
Understanding the functional properties of the motor cortex is a key step to developing effective neuroprosthetic and computer interfaces for amputees and patients with spinal cord injury. Most efforts have been directed towards studying the upper limb region of the motor cortex. Little has been done in the way of addressing lower limb motor cortical physiology. In this study, we implanted multiple microelectrode arrays along the central sulcus in the primary motor cortex of a macaque monkey. Using intracortical microstimulation, we identified neurons that evoked leg movements, either exclusively or mostly, and we studied their firing activity during a center-out arm movement task. We found that some of these neurons modulated their firing rate during arm movement. Surprisingly, we found that some of these neurons even had selective tuning to the direction of arm movement. We built a decoding model which was able to predict the direction of arm movement based on putative leg motor cortical firing activity significantly better than chance. These findings have interesting and surprising implications for understanding motor cortical physiology.
了解运动皮层的功能特性是为截肢者和脊髓损伤患者开发有效的神经假肢和计算机接口的关键一步。大多数的研究都是针对运动皮层的上肢区域。关于下肢运动皮质生理的研究很少。在这项研究中,我们沿着猕猴初级运动皮层的中央沟植入了多个微电极阵列。通过皮质内微刺激,我们确定了引起腿部运动的神经元,无论是完全的还是大部分的,我们研究了它们在手臂运动任务中的放电活动。我们发现这些神经元中的一些在手臂运动时调节了它们的放电速率。令人惊讶的是,我们发现其中一些神经元甚至有选择性地调整手臂运动的方向。我们建立了一个解码模型,该模型能够根据假定的腿部运动皮层放电活动来预测手臂运动的方向,明显优于随机。这些发现对于理解运动皮质生理学具有有趣和令人惊讶的意义。
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引用次数: 0
Improving Cardiopulmonary Resuscitation (CPR) outcomes using model based optimization. 基于模型优化改善心肺复苏(CPR)结果。
D. Bender, A. Jalali, C. Nataraj
Cardiopulmonary Resuscitation (CPR) outcomes are far from optimal as practiced today, and prior work has documented that among probable reasons is the fact that the procedure remains to be fully understood. In an attempt to gain a broader understanding of the CPR physiology and the elemental principles underlying the CPR outcomes, this study proposes a novel approach. The analysis is carried out in three major steps. First, an appropriate cardiovascular system model was adopted and simulated using real CPR data as the input. Next, a function was fitted to the input data in order to obtain an input function with controllable parameters. In the last step, the parameters of the obtained input function were optimized with respect to the objective function that was constrained by the simulated cardiopulmonary values of the model. The results of this preliminary analysis illustrate that the developed framework reflects the findings of numerous studies and shows that this innovative approach can have a great impact on the CPR research field.
心肺复苏术(CPR)的效果远未达到当今实践的最佳效果,先前的工作已经证明,可能的原因之一是该程序仍有待完全理解。为了更广泛地了解心肺复苏术的生理学和心肺复苏术结果的基本原理,本研究提出了一种新的方法。分析分三个主要步骤进行。首先,采用合适的心血管系统模型,以真实心肺复苏数据作为输入进行仿真。然后对输入数据拟合函数,得到参数可控的输入函数。最后一步,根据模型模拟的心肺值约束的目标函数,对得到的输入函数的参数进行优化。这一初步分析的结果表明,开发的框架反映了大量研究的结果,并表明这种创新的方法可以对心肺复苏术研究领域产生重大影响。
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引用次数: 0
Frameless stereotactic radiosurgery (fSRS) end-to-end test with EBT-XD gafchromic film. 无框架立体定向放射外科(fSRS)端到端EBT-XD变色膜测试。
Yulin Song, C. Obcemea, B. Mueller, B. Mychalczak
Frame-based stereotactic radiosurgery (SRS) has been widely used to treat functional disorders, vascular lesions, and primary benign and malignant tumors. Recently, SRS is being increasingly used to treat solitary brain metastases. However, due to its highly invasive nature, frame-based SRS is being gradually replaced by frameless SRS (fSRS). fSRS aims at improving patient comfort and achieving stable patient immobilization with non-invasive means and accurate target localization with image guidance technique. Owing to its inherent complexity and high risk, it is imperative to perform a comprehensive and rigorous end-to-end test prior to its clinical implementation. In this paper, we present our experience and results of fSRS end-to-end test with the latest EBT-XD Gafchromic film for a Varian Trilogy linear accelerator.
基于框架的立体定向放射外科(SRS)已广泛应用于功能障碍、血管病变和原发性良恶性肿瘤的治疗。最近,SRS越来越多地被用于治疗孤立性脑转移。然而,基于框架的SRS由于其高侵入性,正逐渐被无框架SRS (fSRS)所取代。fSRS旨在通过无创手段提高患者舒适度,实现稳定的患者固定,并通过图像引导技术精确定位目标。由于其固有的复杂性和高风险,在临床应用之前必须进行全面严格的端到端测试。本文介绍了利用最新的EBT-XD Gafchromic薄膜对瓦里安三部曲直线加速器进行fSRS端到端测试的经验和结果。
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引用次数: 0
Association between visuomotor adaptation and mathematics skills. 视觉运动适应与数学技能的关系。
M. N. Anwar, R. Rehman, U. Hassan
Learning a new motor skill involves multiple cognitive aspects such as attention, planning, prioritizing, execution, and error correction. In current study, we examined whether the students opted for pure mathematics at their undergraduate level have enhanced motor skills as compared to those pursuing biological sciences at the same level of education. A total of twenty subjects participated in a visuomotor adaptation task. The results showed that the overall movement related errors in subjects with mathematics background were lower than the biosciences students (p = 0.04). On contrary the learning index of biosciences students was greater at the beginning of the task (p<0.01). The result shows that the learning a new motor skill is influenced by previous knowledge and educational background and mathematics allows human brain accepting a new motor task correctly.
学习一项新的运动技能涉及多个认知方面,如注意力、计划、优先排序、执行和错误纠正。在本研究中,我们考察了在本科阶段选择纯数学的学生与在相同教育水平上选择生物科学的学生相比,是否有更高的运动技能。共20名被试参与视觉运动适应任务。结果显示,数学专业学生的整体动作相关误差低于生物科学专业学生(p = 0.04)。相反,生物科学专业学生的学习指数在任务开始时更高(p<0.01)。结果表明,学习一项新的运动技能会受到先前的知识和教育背景的影响,数学可以使人脑正确地接受一项新的运动任务。
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引用次数: 0
An elementary model for exploring the pathogenesis of depression. 探索抑郁症发病机制的初步模型。
D. Fernando
A preliminary model for exploring the pathogenesis of depression that involves genetic and environmental factors is described using a system of linear differential equation. The influence of environmental factors essentially involves random life events, which are modelled using a stochastic differential equation. Different scenarios, including the trajectory of the pathogenesis of depression and immunity, are described by model simulation.
一个初步的模型,探讨抑郁症的发病机制涉及遗传和环境因素描述了一个系统的线性微分方程。环境因素的影响基本上涉及随机生活事件,这些事件是用随机微分方程建模的。不同的情景,包括抑郁症和免疫的发病轨迹,通过模型模拟来描述。
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引用次数: 0
Reliability of a cortical surface-based analysis with subcortical regression in the identification of resting-state functional networks. 在静息状态功能网络的识别中,基于皮层表面的分析与皮层下回归的可靠性。
R. Lopes, P. Besson, R. Viard, C. Bournonville, C. Delmaire, X. Leclerc
Many methods exist for identifying brain networks in resting-state functional magnetic resonance imaging. During the last decade, there was a growing interest in functional connectivity using surface-based analysis. However, the advantages of this approach against volume-based analysis in a data-driven model are unclear. In this study, we propose an independent component analysis based method to extract the resting-state networks directly on the cortical surface. The components associated with the subcortical regions are identified by multiple linear regressions between the signals in subcortical voxels and independent components time courses. The accuracy and stability of our method were evaluated using resampling statistics calculated on 76 healthy male subjects and compared to those obtained with a similar volume-based approach. Seven of the most representative resting-state networks reported in previous studies were identified and used to compare both approaches. Our findings suggest that surface-based approach combined with subcortical linear regression is more sensitive and reproducible than similar volume-based approach for the extraction of resting-state networks.
静息状态功能磁共振成像识别脑网络的方法有很多。在过去的十年中,人们对使用基于表面的分析进行功能连接的兴趣越来越大。然而,这种方法相对于数据驱动模型中基于量的分析的优势还不清楚。在这项研究中,我们提出了一种基于独立分量分析的方法来直接提取皮层表面的静息状态网络。与皮层下区域相关的分量通过皮层下体素信号和独立分量时间过程之间的多重线性回归来识别。我们的方法的准确性和稳定性通过对76名健康男性受试者计算的重采样统计量进行评估,并与类似的基于体积的方法获得的结果进行比较。在之前的研究中,七个最具代表性的静息状态网络被确定并用于比较两种方法。我们的研究结果表明,对于静息状态网络的提取,基于表面的方法结合皮层下线性回归比类似的基于体积的方法更敏感和可重复性。
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引用次数: 0
Nanostructured bioluminescence quenching sensor for detecting glucose. 用于葡萄糖检测的纳米结构生物发光猝灭传感器。
Longyan Chen, Longyi Chen, Jin Zhang
A new nanostructured biosensor by applying bioluminescent quenching technique is developed for detecting small molecules, e.g. glucose, at low concentration. It demonstrates the effect of glucose on the interaction between β-cyclodextrin (β-CD) conjugated luciferase and phenylboronic acid (PBA) conjugated gold nanoparticles (Au NPs).
利用生物发光猝灭技术,研制了一种用于检测低浓度小分子(如葡萄糖)的新型纳米结构生物传感器。研究了葡萄糖对β-环糊精(β-CD)偶联荧光素酶与苯硼酸(PBA)偶联金纳米粒子(Au NPs)相互作用的影响。
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引用次数: 0
Estimating apnea-hypopnea index only from an accelerometer signal measured on the chest. 仅从胸部测量的加速度计信号估计呼吸暂停低通气指数。
Yasunobu Yamauchi, S. Fuke, Kanako Nakayama, Jun’ya Takakura, Hitoshi Usuniwa, Keiji Koike, E. Ouchi, N. Doi
Sleep apnea syndrome (SAS) is becoming a public concern in the field of preventive medicine because it causes more deleterious diseases. However, the majority of patients are not diagnosed and an easier-to-use, lower-cost device for screening of SAS is needed compared to the existing multimodal devices. In this study, we developed and tested a method to estimate the apnea-hypopnea index (AHI), which is the measure of severity of SAS, only from an accelerometer signal measured on the chest. Simultaneous recordings of overnight sleep polysomnography and accelerometer signal were conducted for 50 participants. Three prediction variables were extracted from the accelerometer signal: (i) power of vibration caused by snoring, (ii) variability of frequency of vibration caused by snoring, and (iii) the number of times of rapid changing in the amplitudes of the chest movement accompanied by breathing efforts. Multiple regression analysis was applied to estimate AHI, and the agreement between estimated AHI and true AHI was evaluated by a leave-one-out strategy. The correlation coefficient between the estimated AHI and the true AHI was 0.759, and the sensitivity and the specificity with the threshold of AHI=15 were 83.3% and 88.5%, respectively. Considering the fact that our method requires only an accelerometer to estimate AHI, it has the potential to be a cost-effective way of screening SAS patients.
睡眠呼吸暂停综合征(SAS)因其引起的疾病危害更大,已成为预防医学领域普遍关注的问题。然而,大多数患者没有得到诊断,与现有的多模式设备相比,需要一种更容易使用、成本更低的设备来筛查SAS。在这项研究中,我们开发并测试了一种方法来估计呼吸暂停低通气指数(AHI),这是SAS严重程度的衡量标准,仅从胸部测量的加速度计信号。同时记录50名参与者的夜间睡眠多导睡眠图和加速度计信号。从加速度计信号中提取三个预测变量:(i)打鼾引起的振动功率,(ii)打鼾引起的振动频率的变异性,以及(iii)伴随着呼吸努力的胸部运动幅度快速变化的次数。采用多元回归分析估算AHI,并采用留一策略评估估算AHI与真实AHI的一致性。估算AHI与真实AHI的相关系数为0.759,以AHI=15为阈值时的敏感性为83.3%,特异性为88.5%。考虑到我们的方法只需要一个加速度计来估计AHI,它有可能成为一种具有成本效益的筛查SAS患者的方法。
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引用次数: 0
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Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference
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