Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference最新文献
Pub Date : 2015-08-01DOI: 10.1109/EMBC.2015.7318950
Igor Luiz Moura, R. von Borries, C. Miosso, F. Soares
Electromyographic signals are of great importance to current biomedical research society since they may be used in several ways as, for example, in the diagnosis of neuromuscular diseases, the control of active prosthetic limbs as well as the test and validation of medical equipment.
{"title":"Spatially distributed surface electromyography signal simulator.","authors":"Igor Luiz Moura, R. von Borries, C. Miosso, F. Soares","doi":"10.1109/EMBC.2015.7318950","DOIUrl":"https://doi.org/10.1109/EMBC.2015.7318950","url":null,"abstract":"Electromyographic signals are of great importance to current biomedical research society since they may be used in several ways as, for example, in the diagnosis of neuromuscular diseases, the control of active prosthetic limbs as well as the test and validation of medical equipment.","PeriodicalId":72689,"journal":{"name":"Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference","volume":"1 1","pages":"2705-8"},"PeriodicalIF":0.0,"publicationDate":"2015-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83343967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-08-01DOI: 10.1109/EMBC.2015.7319399
Mengdie Wang, Ning Guo, Hui Zhang, Georges Elfhakri, Guangshu Hu, Quanzheng Li
Traditional data-driven respiratory gating method is capable of detecting breathing cycles directly from positron emission tomography (PET) data, but usually fails at low SNR, particularly at low dose PET/CT study. Time-of-flight (TOF) PET has the potential to improve the SNR. In order for TOF information to reduce the statistical noise and boost the performance of respiratory gating, we present a robust data-driven respiratory gating method using TOF information, which retrospectively derived the respiratory signal from the acquired TOF-PET data. The PET data was acquired in list mode format and analyzed in sinogram space. The method was demonstrated with patient datasets acquired on a TOF PET/CT system. Data-driven gating methods by center of mass (COM) and principle component analysis (PCA) algorithm were successfully performed on nonTOF PET and TOF PET dataset. To assess the accuracy of the data-driven respiratory signal, a hardware-based signal was acquired for comparison. The study showed that retrospectively respiratory gating using TOF sinograms has improved the SNR, and outperforms the non-TOF gating under both COM and PCA algorithms.
{"title":"Retrospective data-driven respiratory gating for PET using TOF information.","authors":"Mengdie Wang, Ning Guo, Hui Zhang, Georges Elfhakri, Guangshu Hu, Quanzheng Li","doi":"10.1109/EMBC.2015.7319399","DOIUrl":"https://doi.org/10.1109/EMBC.2015.7319399","url":null,"abstract":"Traditional data-driven respiratory gating method is capable of detecting breathing cycles directly from positron emission tomography (PET) data, but usually fails at low SNR, particularly at low dose PET/CT study. Time-of-flight (TOF) PET has the potential to improve the SNR. In order for TOF information to reduce the statistical noise and boost the performance of respiratory gating, we present a robust data-driven respiratory gating method using TOF information, which retrospectively derived the respiratory signal from the acquired TOF-PET data. The PET data was acquired in list mode format and analyzed in sinogram space. The method was demonstrated with patient datasets acquired on a TOF PET/CT system. Data-driven gating methods by center of mass (COM) and principle component analysis (PCA) algorithm were successfully performed on nonTOF PET and TOF PET dataset. To assess the accuracy of the data-driven respiratory signal, a hardware-based signal was acquired for comparison. The study showed that retrospectively respiratory gating using TOF sinograms has improved the SNR, and outperforms the non-TOF gating under both COM and PCA algorithms.","PeriodicalId":72689,"journal":{"name":"Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference","volume":"33 1","pages":"4520-3"},"PeriodicalIF":0.0,"publicationDate":"2015-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74479420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-01-01DOI: 10.1109/EMBC.2015.7318597
Unsoo Ha, Changhyeon Kim, Yongsu Lee, Hyunki Kim, Taehwan Roh, Hoi-Jun Yoo
The multimodal stress monitoring headband is proposed for mobile stress management system. It is composed of headband and earplugs. Electroencephalography (EEG), hemoencephalography (HEG) and heart-rate variability (HRV) can be achieved simultaneously in the proposed system for user status estimation. With canonical correlation analysis (CCA) and temporal-kernel CCA (tkCCA) algorithm, those different signals can be combined for maximum correlation. Thanks to the proposed combination algorithm, the accuracy of the proposed system increased up to 19 percentage points than unimodal monitoring system in n-back task.
{"title":"A multimodal stress monitoring system with canonical correlation analysis.","authors":"Unsoo Ha, Changhyeon Kim, Yongsu Lee, Hyunki Kim, Taehwan Roh, Hoi-Jun Yoo","doi":"10.1109/EMBC.2015.7318597","DOIUrl":"https://doi.org/10.1109/EMBC.2015.7318597","url":null,"abstract":"The multimodal stress monitoring headband is proposed for mobile stress management system. It is composed of headband and earplugs. Electroencephalography (EEG), hemoencephalography (HEG) and heart-rate variability (HRV) can be achieved simultaneously in the proposed system for user status estimation. With canonical correlation analysis (CCA) and temporal-kernel CCA (tkCCA) algorithm, those different signals can be combined for maximum correlation. Thanks to the proposed combination algorithm, the accuracy of the proposed system increased up to 19 percentage points than unimodal monitoring system in n-back task.","PeriodicalId":72689,"journal":{"name":"Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference","volume":"7 1","pages":"1263-6"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74673124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This study presented a closed-loop adaptive calibration (CLAC) scheme where subjects could get instantaneous feedback of their movements and alter their motions immediately to update the model parameters to enhance its ability. The real-time performance was compared between the conventional open-loop calibration (OLC) and the presented CLAC based on three metrics (motion-selection time, motion-completion time and motion-completion rate). The CLAC performed slightly better than the OLC, but the difference was not significant. This was the first study designed to investigate the effects of CLAC for pattern recognition-based myoelectric control (discrete movement). The CLAC could be potentially applied in the multiuser interface to make the adaptation of the common model to a novel user efficiently and flexibly.
{"title":"A comparison of open-loop and closed-loop adaptive calibration for pattern recognition based myoelectric control.","authors":"Jiayuan He, Dingguo Zhang, Xinjun Sheng, Xiangyang Zhu","doi":"10.1109/EMBC.2015.7318568","DOIUrl":"https://doi.org/10.1109/EMBC.2015.7318568","url":null,"abstract":"This study presented a closed-loop adaptive calibration (CLAC) scheme where subjects could get instantaneous feedback of their movements and alter their motions immediately to update the model parameters to enhance its ability. The real-time performance was compared between the conventional open-loop calibration (OLC) and the presented CLAC based on three metrics (motion-selection time, motion-completion time and motion-completion rate). The CLAC performed slightly better than the OLC, but the difference was not significant. This was the first study designed to investigate the effects of CLAC for pattern recognition-based myoelectric control (discrete movement). The CLAC could be potentially applied in the multiuser interface to make the adaptation of the common model to a novel user efficiently and flexibly.","PeriodicalId":72689,"journal":{"name":"Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference","volume":"4 1","pages":"1144-7"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76845675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In recent years, minimally invasive vascular surgery is widely applied in treatment of cardiovascular diseases, and the manipulation of the guidewire is the essential skill for this surgery. Lots of time and money have to be taken to achieve the skill. In this paper, we present a multithreading guidewire simulator which can help the apprentice to gain the skill and modeling the guidewire is the core technique of the simulator. The guidewire is modeled by a fast and stable method based on the Cosserat theory of elastic rods. The method describes the behavior of the guidewire with the Lagrange equations of motion and it uses the penalty method to maintain constraints. We further propose a simplified solving procedure for the guidewire model. Finally, some experiments are conducted to evaluate the effectiveness of this model.
{"title":"Fast and stable guidewire simulator for minimally invasive vascular surgery.","authors":"Zhan-Jie Gao, Xiao-Liang Xie, Gui-Bin Bian, Jian-Long Hao, Zhen-Qiu Feng, Zeng-Guang Hou","doi":"10.1109/EMBC.2015.7319712","DOIUrl":"https://doi.org/10.1109/EMBC.2015.7319712","url":null,"abstract":"In recent years, minimally invasive vascular surgery is widely applied in treatment of cardiovascular diseases, and the manipulation of the guidewire is the essential skill for this surgery. Lots of time and money have to be taken to achieve the skill. In this paper, we present a multithreading guidewire simulator which can help the apprentice to gain the skill and modeling the guidewire is the core technique of the simulator. The guidewire is modeled by a fast and stable method based on the Cosserat theory of elastic rods. The method describes the behavior of the guidewire with the Lagrange equations of motion and it uses the penalty method to maintain constraints. We further propose a simplified solving procedure for the guidewire model. Finally, some experiments are conducted to evaluate the effectiveness of this model.","PeriodicalId":72689,"journal":{"name":"Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference","volume":"75 1","pages":"5809-12"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80185795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-01-01DOI: 10.1109/EMBC.2015.7318492
Wen-Yen Huang, Yu-Wei Cheng, Kea-Tiong Tang
This article presents a low-noise readout front-end suitable for Electroencephalogram (EEG) acquisition. The chip includes 8-channel fully-differential instrumentation amplifiers, utilizing chopper stabilization technique for reducing the flicker noise, each amplifier with a small Gm-C low-pass filter, a programmable gain amplifier, and a 10-bit successive approximation register (SAR) ADC with a detect logic for DAC switching. The chip is fabricated with the TSMC 90nm CMOS process. The low-noise readout front-end has simulated frequency response from 0.57 Hz to 213 Hz, programmable gain from 54.4 dB to 87.6 dB, integrated input-referred noise of 0.358 μVrms within EEG bandwidth, a noise efficiency factor (NEF) of 2.43, and a power efficiency factor (PEF) of 2.95. The overall system consumes 32.08 μW under 0.5-V supply.
{"title":"A 0.5-V multi-channel low-noise readout front-end for portable EEG acquisition.","authors":"Wen-Yen Huang, Yu-Wei Cheng, Kea-Tiong Tang","doi":"10.1109/EMBC.2015.7318492","DOIUrl":"https://doi.org/10.1109/EMBC.2015.7318492","url":null,"abstract":"This article presents a low-noise readout front-end suitable for Electroencephalogram (EEG) acquisition. The chip includes 8-channel fully-differential instrumentation amplifiers, utilizing chopper stabilization technique for reducing the flicker noise, each amplifier with a small Gm-C low-pass filter, a programmable gain amplifier, and a 10-bit successive approximation register (SAR) ADC with a detect logic for DAC switching. The chip is fabricated with the TSMC 90nm CMOS process. The low-noise readout front-end has simulated frequency response from 0.57 Hz to 213 Hz, programmable gain from 54.4 dB to 87.6 dB, integrated input-referred noise of 0.358 μVrms within EEG bandwidth, a noise efficiency factor (NEF) of 2.43, and a power efficiency factor (PEF) of 2.95. The overall system consumes 32.08 μW under 0.5-V supply.","PeriodicalId":72689,"journal":{"name":"Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference","volume":"40 1","pages":"837-40"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86276952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-01-01DOI: 10.1109/EMBC.2015.7319635
Yang Yu, Qian Wang, Jing Liu
With the growing attention on personal health, keeping track of the health related parameters has become an important issue, which is quite useful to increase people's living quality and reduce unpredicted risks. However, conventional physical checks are discrete and transient, which is incapable for the health monitor of daily living. Dedicated to everyday physiological monitor, we have developed a multi-parameter smart armband which is able record pulse, temperature and triaxial accelerations continuously. With the wearable device and signal processing algorithm, experiments of data acquisition in the daily living have been implemented on the volunteers. The long period record of 38 hours has demonstrated its feasibility of a total record without disturbing. And both historical and cross comparisons on the parameter correlation analysis have proven the valuable health information that the armband could reveal. As an integrated sensor module, the smart armband is simple and non-obtrusive, thus opens a promising approach towards the pervasive health monitor, especially for the elder population.
{"title":"Pervasive health monitor and analysis based on multi-parameter smart armband.","authors":"Yang Yu, Qian Wang, Jing Liu","doi":"10.1109/EMBC.2015.7319635","DOIUrl":"https://doi.org/10.1109/EMBC.2015.7319635","url":null,"abstract":"With the growing attention on personal health, keeping track of the health related parameters has become an important issue, which is quite useful to increase people's living quality and reduce unpredicted risks. However, conventional physical checks are discrete and transient, which is incapable for the health monitor of daily living. Dedicated to everyday physiological monitor, we have developed a multi-parameter smart armband which is able record pulse, temperature and triaxial accelerations continuously. With the wearable device and signal processing algorithm, experiments of data acquisition in the daily living have been implemented on the volunteers. The long period record of 38 hours has demonstrated its feasibility of a total record without disturbing. And both historical and cross comparisons on the parameter correlation analysis have proven the valuable health information that the armband could reveal. As an integrated sensor module, the smart armband is simple and non-obtrusive, thus opens a promising approach towards the pervasive health monitor, especially for the elder population.","PeriodicalId":72689,"journal":{"name":"Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference","volume":"39 1","pages":"5493-6"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79222641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-01-01DOI: 10.1109/EMBC.2015.7318955
Renata Coelho Borges, M. Holsbach Costa
This work presents a theoretical analysis of the prediction-error method-based adaptive feedback canceller in hearing aid applications. The studied scene takes into account the occlusion effect caused by the partial or complete closing of the ventilation opening. Such a situation may occur in high gain applications to avoid undesired whistling. Deterministic recursive equations and steady-state conditions were derived for the mean weight behaviour of the predictor and the adaptive filter. The expected theoretical predictions were compared to Monte Carlo simulations, showing very accurate agreement. The simulation results suggest the steady-state performance of this feedback canceller is not affected by the occlusion effect, however the occlusion is still perceived, being annoying to the user.
{"title":"Influence of the occlusion effect over the prediction-error feedback cancellation system in hearing aids.","authors":"Renata Coelho Borges, M. Holsbach Costa","doi":"10.1109/EMBC.2015.7318955","DOIUrl":"https://doi.org/10.1109/EMBC.2015.7318955","url":null,"abstract":"This work presents a theoretical analysis of the prediction-error method-based adaptive feedback canceller in hearing aid applications. The studied scene takes into account the occlusion effect caused by the partial or complete closing of the ventilation opening. Such a situation may occur in high gain applications to avoid undesired whistling. Deterministic recursive equations and steady-state conditions were derived for the mean weight behaviour of the predictor and the adaptive filter. The expected theoretical predictions were compared to Monte Carlo simulations, showing very accurate agreement. The simulation results suggest the steady-state performance of this feedback canceller is not affected by the occlusion effect, however the occlusion is still perceived, being annoying to the user.","PeriodicalId":72689,"journal":{"name":"Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference","volume":"68 1","pages":"2725-8"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75335133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-01-01DOI: 10.1109/EMBC.2015.7318948
Pengling Ren, Xiaofei Li, Fan Fan, Xiran Cai, He Gong, Yubo Fan, Haijun Niu
In this study, we observed the age-related changes of glycosaminoglycan (GAG) content of human hip joint cartilage based on ultrasound (US). Seventy human hip cartilage-bone samples were collected from hip-fracture patients (ages 51 to 96) and divided into 5 groups (10 years in an age group). They were firstly measured by ultrasound to obtain quantitative acoustic parameters, including the speed of sound (SOS), US amplitude attenuation coefficient (UAA) and normalized broadband US attenuation coefficient (nBUA). Then the samples were stained for GAG with toluidine blue. Results showed SOS, UAA, nBUA decreased by 5.49%, 36.67%, 25.57% from 50-80 age group (p<;0.01), but increased by 0.34%, 1.19%, 5.23% in the 90 age group compared with the 80 age group, respectively. There were linear correlations between SOS and GAG optical density (r=0.825, p<;0.01), as well as UAA and GAG optical density (r=0.708, p <; 0.01). However, nBUA showed less significant linear correlation to GAG optical density (r=0.688, p <; 0.07). In summary, GAG content of hip joint cartilage varied with aging in elderly people and conventional ultrasound can potentially be used to detect the age-related changes of acoustic parameters of human hip joint cartilage.
{"title":"Ultrasound observation of GAG content of human hip joint cartilage in different old age groups.","authors":"Pengling Ren, Xiaofei Li, Fan Fan, Xiran Cai, He Gong, Yubo Fan, Haijun Niu","doi":"10.1109/EMBC.2015.7318948","DOIUrl":"https://doi.org/10.1109/EMBC.2015.7318948","url":null,"abstract":"In this study, we observed the age-related changes of glycosaminoglycan (GAG) content of human hip joint cartilage based on ultrasound (US). Seventy human hip cartilage-bone samples were collected from hip-fracture patients (ages 51 to 96) and divided into 5 groups (10 years in an age group). They were firstly measured by ultrasound to obtain quantitative acoustic parameters, including the speed of sound (SOS), US amplitude attenuation coefficient (UAA) and normalized broadband US attenuation coefficient (nBUA). Then the samples were stained for GAG with toluidine blue. Results showed SOS, UAA, nBUA decreased by 5.49%, 36.67%, 25.57% from 50-80 age group (p<;0.01), but increased by 0.34%, 1.19%, 5.23% in the 90 age group compared with the 80 age group, respectively. There were linear correlations between SOS and GAG optical density (r=0.825, p<;0.01), as well as UAA and GAG optical density (r=0.708, p <; 0.01). However, nBUA showed less significant linear correlation to GAG optical density (r=0.688, p <; 0.07). In summary, GAG content of hip joint cartilage varied with aging in elderly people and conventional ultrasound can potentially be used to detect the age-related changes of acoustic parameters of human hip joint cartilage.","PeriodicalId":72689,"journal":{"name":"Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference","volume":"19 1","pages":"2697-700"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82564746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-01-01DOI: 10.1109/EMBC.2015.7319417
Cheng Zhang, Guanghao Zhang, Aihua Wang, Changzhe Wu, Xiaolin Huo
OBJECTIVES We explored whether oscillating field stimulation (OFS) could efficiently promote motor function recovery in rat model of spinal cord injury. METHODS SD rats with spinal cord injury induced by Allen method was divided into two groups, experimental group rats received active stimulator units and control group rats received sham (inoperative) stimulator units. The electric field intensity was 600μV/mm, and the polarity alternated every 15 min. RESULTS The results showed that the experimental group rats had significantly better locomotor function recovery (inclined-plane testing and modified Tarlov motor grading scale) 5 weeks after the injury (P<;0.05). OFS treatment significantly decreased motor evoked potential (MEP) latency differences and amplitude differences 4 w and 8 w post injury (P<;0.05, P<;0.01). Furthermore, the number of axons was quantified by immunofluorescence staining of nerve fiber (NF), increased axon numbers were observed at 4 w and 8 w in experimental group (P<;0.05). CONCLUSIONS These findings suggest OFS can promote motor function recovery in SCI rats, and this effect may be related to the improving axon regeneration in spinal cord.
{"title":"Oscillating field stimulation promotes recovery after spinal cord injury in rats: Assessment using behavioral, electrophysiological and histological evaluations.","authors":"Cheng Zhang, Guanghao Zhang, Aihua Wang, Changzhe Wu, Xiaolin Huo","doi":"10.1109/EMBC.2015.7319417","DOIUrl":"https://doi.org/10.1109/EMBC.2015.7319417","url":null,"abstract":"OBJECTIVES We explored whether oscillating field stimulation (OFS) could efficiently promote motor function recovery in rat model of spinal cord injury. METHODS SD rats with spinal cord injury induced by Allen method was divided into two groups, experimental group rats received active stimulator units and control group rats received sham (inoperative) stimulator units. The electric field intensity was 600μV/mm, and the polarity alternated every 15 min. RESULTS The results showed that the experimental group rats had significantly better locomotor function recovery (inclined-plane testing and modified Tarlov motor grading scale) 5 weeks after the injury (P<;0.05). OFS treatment significantly decreased motor evoked potential (MEP) latency differences and amplitude differences 4 w and 8 w post injury (P<;0.05, P<;0.01). Furthermore, the number of axons was quantified by immunofluorescence staining of nerve fiber (NF), increased axon numbers were observed at 4 w and 8 w in experimental group (P<;0.05). CONCLUSIONS These findings suggest OFS can promote motor function recovery in SCI rats, and this effect may be related to the improving axon regeneration in spinal cord.","PeriodicalId":72689,"journal":{"name":"Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference","volume":"20 1","pages":"4594-7"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81770352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference
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