首页 > 最新文献

COVID最新文献

英文 中文
Public Decision Policy for Controlling COVID-19 Outbreaks Using Control System Engineering 利用控制系统工程控制 COVID-19 爆发的公共决策政策
Pub Date : 2024-01-08 DOI: 10.3390/covid4010005
H. Patiño, J. Pucheta, Cristian Rodríguez Rivero, Santiago Tosetti
This work is a response to the appeal of various international health organizations and the Automatic Control Community for collaboration in addressing Coronavirus/COVID-19 challenges during the initial stages of the pandemic. Specifically, this study presents scientific evidence supporting the efficacy of three primary non-pharmacological strategies for pandemic mitigation. We propose a control system to aid in formulating a public decision policy aimed at managing the spread of COVID-19 caused by the SARS-CoV-2 virus, commonly known as coronavirus. The primary objective is to prevent overwhelming healthcare systems by averting the saturation of intensive care units (ICUs). In the context of COVID-19, understanding the peak infection rate and its time delay is crucial for preparing healthcare infrastructure and ensuring an adequate supply of intensive care units equipped with automatic ventilators. While it is widely recognized that public policies encompassing confinement and social distancing can flatten the epidemiological curve and provide time to bolster healthcare resources, there is a dearth of studies examining this pivotal issue from the perspective of control system theory. In this study, we introduce a control system founded on three prevailing non-pharmacological tools for epidemic and pandemic mitigation: social distancing, confinement, and population-wide testing and isolation in regions experiencing community transmission. Our analysis and control system design rely on the susceptible-exposed–infected–recovered–deceased (SEIRD) mathematical model, which describes the temporal dynamics of a pandemic, tailored in this research to account for the temporal and spatial characteristics of SARS-CoV-2 behavior. This model incorporates the influence of conducting tests with subsequent population isolation. An On–off control strategy is analyzed, and a proportional–integral–derivative (PID) controller is proposed to generate a sequence of public policy decisions. The proposed control system employs the required number of critical beds and ICUs as feedback signals and compares these with the available bed capacity to generate an error signal, which is utilized as input for the PID controller. The control actions outlined involve five phases of “Social Distancing and Confinement” (SD&C) to be implemented by governmental authorities. Consequently, the control system generates a policy sequence for SD&C, with applications occurring on a weekly or biweekly basis. The simulation results underscore the favorable impact of these three mitigation strategies against the coronavirus, illustrating their efficacy in controlling the outbreak and thereby mitigating the risk of healthcare system collapse.
这项工作是对各国际卫生组织和自动控制界呼吁合作应对大流行初期冠状病毒/COVID-19 挑战的回应。具体来说,本研究提出了科学证据,支持缓解大流行的三种主要非药物策略的有效性。我们提出了一个控制系统,以帮助制定公共决策政策,管理由 SARS-CoV-2 病毒(俗称冠状病毒)引起的 COVID-19 的传播。其主要目的是通过避免重症监护室(ICU)的饱和来防止医疗系统不堪重负。在 COVID-19 的背景下,了解高峰感染率及其时间延迟对于准备医疗基础设施和确保配备自动呼吸机的重症监护室的充足供应至关重要。虽然人们普遍认为,包括隔离和社会疏远在内的公共政策可以拉平流行病学曲线,并为加强医疗资源提供时间,但从控制系统理论的角度来研究这一关键问题的研究还很缺乏。在本研究中,我们介绍了一种控制系统,该系统建立在三种流行病和大流行病缓解的常用非药物工具之上:社会隔离、封闭以及在出现社区传播的地区进行全人群检测和隔离。我们的分析和控制系统设计依赖于易感者-暴露者-感染者-康复者-死亡者(SEIRD)数学模型,该模型描述了大流行的时间动态,本研究根据 SARS-CoV-2 行为的时间和空间特征进行了调整。该模型纳入了进行试验和随后的人群隔离的影响。对开关控制策略进行了分析,并提出了一个比例-积分-派生(PID)控制器来生成一系列公共政策决策。建议的控制系统采用所需的危重病床和重症监护室数量作为反馈信号,并将其与可用病床容量进行比较,以产生误差信号,该误差信号被用作 PID 控制器的输入信号。概述的控制行动涉及政府当局实施的五个 "社会隔离和封闭"(SD&C)阶段。因此,控制系统会生成一个 SD&C 政策序列,每周或每两周应用一次。模拟结果强调了这三种缓解策略对冠状病毒的有利影响,说明了它们在控制疫情爆发方面的功效,从而降低了医疗系统崩溃的风险。
{"title":"Public Decision Policy for Controlling COVID-19 Outbreaks Using Control System Engineering","authors":"H. Patiño, J. Pucheta, Cristian Rodríguez Rivero, Santiago Tosetti","doi":"10.3390/covid4010005","DOIUrl":"https://doi.org/10.3390/covid4010005","url":null,"abstract":"This work is a response to the appeal of various international health organizations and the Automatic Control Community for collaboration in addressing Coronavirus/COVID-19 challenges during the initial stages of the pandemic. Specifically, this study presents scientific evidence supporting the efficacy of three primary non-pharmacological strategies for pandemic mitigation. We propose a control system to aid in formulating a public decision policy aimed at managing the spread of COVID-19 caused by the SARS-CoV-2 virus, commonly known as coronavirus. The primary objective is to prevent overwhelming healthcare systems by averting the saturation of intensive care units (ICUs). In the context of COVID-19, understanding the peak infection rate and its time delay is crucial for preparing healthcare infrastructure and ensuring an adequate supply of intensive care units equipped with automatic ventilators. While it is widely recognized that public policies encompassing confinement and social distancing can flatten the epidemiological curve and provide time to bolster healthcare resources, there is a dearth of studies examining this pivotal issue from the perspective of control system theory. In this study, we introduce a control system founded on three prevailing non-pharmacological tools for epidemic and pandemic mitigation: social distancing, confinement, and population-wide testing and isolation in regions experiencing community transmission. Our analysis and control system design rely on the susceptible-exposed–infected–recovered–deceased (SEIRD) mathematical model, which describes the temporal dynamics of a pandemic, tailored in this research to account for the temporal and spatial characteristics of SARS-CoV-2 behavior. This model incorporates the influence of conducting tests with subsequent population isolation. An On–off control strategy is analyzed, and a proportional–integral–derivative (PID) controller is proposed to generate a sequence of public policy decisions. The proposed control system employs the required number of critical beds and ICUs as feedback signals and compares these with the available bed capacity to generate an error signal, which is utilized as input for the PID controller. The control actions outlined involve five phases of “Social Distancing and Confinement” (SD&C) to be implemented by governmental authorities. Consequently, the control system generates a policy sequence for SD&C, with applications occurring on a weekly or biweekly basis. The simulation results underscore the favorable impact of these three mitigation strategies against the coronavirus, illustrating their efficacy in controlling the outbreak and thereby mitigating the risk of healthcare system collapse.","PeriodicalId":72714,"journal":{"name":"COVID","volume":"49 23","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139447231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Impact of Surgical Delay: A Single Institutional Experience at the Epicenter of the COVID Pandemic Treatment Delays in Women with Endometrial Cancer and Endometrial Intraepithelial Hyperplasia 手术延迟的影响:子宫内膜癌和子宫内膜上皮内瘤增生妇女治疗延迟的单一机构经验
Pub Date : 2023-12-28 DOI: 10.3390/covid4010004
Kieran Seay, Arielle H. Katcher, Maia Hare, Nina Kohn, Hannah Juhel, Gary Goldberg, M. Frimer
The spread of COVID-19 led to a lockdown in New York in March of 2020. Nonemergent surgeries were postponed, including oncologic procedures. The backlog of surgeries was addressed starting May 2020. Our goal was to examine the change in waiting times for endometrial cancer surgeries during the COVID-19 pandemic in our institution. Data on surgery incidence and waiting time was gathered for patients diagnosed with endometrial intraepithelial neoplasia and endometrial cancer. The association between days from diagnosis to surgery was adjusted for age, obesity, presence of comorbid conditions, race, smoking history and diagnosis and was examined using a general linear model. A total of 190 patients were identified for this retrospective study. Five subjects were missing information on race and were excluded from all analyses, resulting in 185 subjects in the final analyses. Mean waiting time during COVID-19 was 70.9 days (95%CI 55.0, 91.3), compared to 49.3 (95%CI 49.8, 63.8) days during the reference period. No significant associations were seen between the time and any of the clinical or demographic factors.
COVID-19 的扩散导致纽约在 2020 年 3 月实行封锁。非紧急手术被推迟,包括肿瘤手术。积压的手术从 2020 年 5 月开始得到解决。我们的目标是研究本机构在 COVID-19 大流行期间子宫内膜癌手术等待时间的变化。我们收集了确诊为子宫内膜上皮内瘤变和子宫内膜癌患者的手术发生率和等待时间数据。从诊断到手术的天数与年龄、肥胖程度、是否有合并症、种族、吸烟史和诊断之间的关系已作调整,并使用一般线性模型进行了检验。这项回顾性研究共确定了 190 名患者。有五名受试者的种族信息缺失,因此被排除在所有分析之外,最终分析结果为 185 名受试者。COVID-19 期间的平均等待时间为 70.9 天(95%CI 55.0,91.3),而参照期为 49.3 天(95%CI 49.8,63.8)。等待时间与任何临床或人口统计学因素之间均无明显关联。
{"title":"The Impact of Surgical Delay: A Single Institutional Experience at the Epicenter of the COVID Pandemic Treatment Delays in Women with Endometrial Cancer and Endometrial Intraepithelial Hyperplasia","authors":"Kieran Seay, Arielle H. Katcher, Maia Hare, Nina Kohn, Hannah Juhel, Gary Goldberg, M. Frimer","doi":"10.3390/covid4010004","DOIUrl":"https://doi.org/10.3390/covid4010004","url":null,"abstract":"The spread of COVID-19 led to a lockdown in New York in March of 2020. Nonemergent surgeries were postponed, including oncologic procedures. The backlog of surgeries was addressed starting May 2020. Our goal was to examine the change in waiting times for endometrial cancer surgeries during the COVID-19 pandemic in our institution. Data on surgery incidence and waiting time was gathered for patients diagnosed with endometrial intraepithelial neoplasia and endometrial cancer. The association between days from diagnosis to surgery was adjusted for age, obesity, presence of comorbid conditions, race, smoking history and diagnosis and was examined using a general linear model. A total of 190 patients were identified for this retrospective study. Five subjects were missing information on race and were excluded from all analyses, resulting in 185 subjects in the final analyses. Mean waiting time during COVID-19 was 70.9 days (95%CI 55.0, 91.3), compared to 49.3 (95%CI 49.8, 63.8) days during the reference period. No significant associations were seen between the time and any of the clinical or demographic factors.","PeriodicalId":72714,"journal":{"name":"COVID","volume":"28 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139148220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genomic Surveillance of SARS-CoV-2 Sequence Variants at Universities in Southwest Idaho 爱达荷州西南部大学对 SARS-CoV-2 序列变异的基因组监测
Pub Date : 2023-12-25 DOI: 10.3390/covid4010003
Jennifer R. Chase, Laura Bond, Daniel J. Vail, Milan Sengthep, Adriana Rodriguez, Joe Christianson, Stephanie F. Hudon, Julia Thom Oxford
Although the impact of the SARS-CoV-2 pandemic on major metropolitan areas is broadly reported and readily available, regions with lower populations and more remote areas in the United States are understudied. The objective of this study is to determine the progression of SARS-CoV-2 sequence variants in a frontier and remote intermountain west state among university-associated communities. This study was conducted at two intermountain west universities from 2020 to 2022. Positive SARS-CoV-2 samples were confirmed by quantitative real-time reverse transcription-polymerase chain reaction and variants were identified by the next-generation sequencing of viral genomes. Positive results were obtained for 5355 samples, representing a positivity rate of 3.5% overall. The median age was 22 years. Viral genomic sequence data were analyzed for 1717 samples and phylogeny was presented. Associations between viral variants, age, sex, and reported symptoms among 1522 samples indicated a significant association between age and the Delta variant (B 1.167.2), consistent with the findings for other regions. An outbreak event of AY122 was detected August–October 2021. A 2-month delay was observed with respect to the timing of the first documented viral infection within this region compared to major metropolitan regions of the US.
尽管 SARS-CoV-2 大流行对大都市地区的影响已被广泛报道并可随时查阅,但对美国人口较少的地区和较偏远地区的研究却不足。本研究的目的是确定 SARS-CoV-2 序列变异在西部边远山区州大学相关社区中的进展情况。这项研究从 2020 年到 2022 年在两所山间西部大学进行。通过定量实时反转录聚合酶链反应确认了 SARS-CoV-2 阳性样本,并通过下一代病毒基因组测序确定了变体。5355份样本检测结果呈阳性,阳性率为3.5%。中位年龄为 22 岁。对 1717 个样本的病毒基因组序列数据进行了分析,并提出了系统发生学。1522 份样本中病毒变异体、年龄、性别和报告症状之间的关联表明,年龄与 Delta 变异体(B 1.167.2)之间存在显著关联,这与其他地区的研究结果一致。2021 年 8 月至 10 月检测到 AY122 爆发。与美国主要大都市地区相比,该地区首次记录到病毒感染的时间推迟了 2 个月。
{"title":"Genomic Surveillance of SARS-CoV-2 Sequence Variants at Universities in Southwest Idaho","authors":"Jennifer R. Chase, Laura Bond, Daniel J. Vail, Milan Sengthep, Adriana Rodriguez, Joe Christianson, Stephanie F. Hudon, Julia Thom Oxford","doi":"10.3390/covid4010003","DOIUrl":"https://doi.org/10.3390/covid4010003","url":null,"abstract":"Although the impact of the SARS-CoV-2 pandemic on major metropolitan areas is broadly reported and readily available, regions with lower populations and more remote areas in the United States are understudied. The objective of this study is to determine the progression of SARS-CoV-2 sequence variants in a frontier and remote intermountain west state among university-associated communities. This study was conducted at two intermountain west universities from 2020 to 2022. Positive SARS-CoV-2 samples were confirmed by quantitative real-time reverse transcription-polymerase chain reaction and variants were identified by the next-generation sequencing of viral genomes. Positive results were obtained for 5355 samples, representing a positivity rate of 3.5% overall. The median age was 22 years. Viral genomic sequence data were analyzed for 1717 samples and phylogeny was presented. Associations between viral variants, age, sex, and reported symptoms among 1522 samples indicated a significant association between age and the Delta variant (B 1.167.2), consistent with the findings for other regions. An outbreak event of AY122 was detected August–October 2021. A 2-month delay was observed with respect to the timing of the first documented viral infection within this region compared to major metropolitan regions of the US.","PeriodicalId":72714,"journal":{"name":"COVID","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139157620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association between Priority Conditions and Access to Care, Treatment of an Ongoing Condition, and Ability to Obtain Prescription Medications among Medicare Beneficiaries during the COVID-19 Pandemic 在 COVID-19 大流行期间,医疗保险受益人中的优先病症与获得护理、正在进行的病症治疗以及获得处方药的能力之间的关系
Pub Date : 2023-12-20 DOI: 10.3390/covid4010002
Matthew C. Dickson, Grant H. Skrepnek
Several comorbid conditions have been observed to be associated with an increased risk of poor outcomes following a diagnosis of COVID-19. The purpose of this investigation was to assess associations between Centers for Medicare and Medicaid Services (CMS) designated priority conditions and an inability to access care, treat ongoing conditions, and obtain prescription medications among Medicare beneficiaries in the United States during the COVID-19 pandemic. Nationally representative CMS Medicare Current Beneficiary Survey (MCBS) COVID-19 Supplement Public Use Files (PUF) were analyzed via bivariable, binomial generalized linear models across three time periods: (1) Summer 2020; (2) Fall 2020; and (3) Winter 2021. Across an estimated 55.3–57.4 million Medicare beneficiaries, approximately one-fifth reported an inability to access at least one type of care at the onset of the pandemic. Significantly worse odds of an ability to get care across various time periods was observed among several priority conditions including immune disorders, cancer, depression, osteoporosis, diabetes, arthritis, and numerous cardiovascular and pulmonary conditions. Among those reporting an inability to access care, approximately one-third involved treatment of an ongoing condition, and under one-tenth involved prescription medications. To identify modifiable risk factors and to develop active interventions, future work should continue to assess the complex associations between outcomes, access to care, comorbidities, evolving healthcare infrastructures, computerization, and various public health initiatives.
据观察,一些合并症与 COVID-19 诊断后不良后果风险增加有关。本调查的目的是评估美国医疗保险和医疗补助服务中心(CMS)指定的优先病症与 COVID-19 大流行期间美国医疗保险受益人无法获得护理、治疗持续病症和获取处方药之间的关联。对具有全国代表性的 CMS 医疗保险当前受益人调查(MCBS)COVID-19 补充公共使用文件(PUF)进行了分析,通过二变量、二项式广义线性模型对三个时间段进行了分析:(1) 2020 年夏季;(2) 2020 年秋季;(3) 2021 年冬季。在约 5530-5740 万名医疗保险受益人中,约有五分之一的人表示在大流行开始时无法获得至少一种类型的护理。据观察,在不同时期,无法获得护理的几率明显降低,其中包括免疫紊乱、癌症、抑郁症、骨质疏松症、糖尿病、关节炎以及多种心血管和肺部疾病。在报告无法获得医疗服务的人群中,约有三分之一涉及到正在进行的疾病治疗,不到十分之一涉及到处方药。为了确定可改变的风险因素并制定积极的干预措施,今后的工作应继续评估结果、获得医疗服务的机会、合并症、不断发展的医疗基础设施、计算机化和各种公共卫生倡议之间的复杂关联。
{"title":"Association between Priority Conditions and Access to Care, Treatment of an Ongoing Condition, and Ability to Obtain Prescription Medications among Medicare Beneficiaries during the COVID-19 Pandemic","authors":"Matthew C. Dickson, Grant H. Skrepnek","doi":"10.3390/covid4010002","DOIUrl":"https://doi.org/10.3390/covid4010002","url":null,"abstract":"Several comorbid conditions have been observed to be associated with an increased risk of poor outcomes following a diagnosis of COVID-19. The purpose of this investigation was to assess associations between Centers for Medicare and Medicaid Services (CMS) designated priority conditions and an inability to access care, treat ongoing conditions, and obtain prescription medications among Medicare beneficiaries in the United States during the COVID-19 pandemic. Nationally representative CMS Medicare Current Beneficiary Survey (MCBS) COVID-19 Supplement Public Use Files (PUF) were analyzed via bivariable, binomial generalized linear models across three time periods: (1) Summer 2020; (2) Fall 2020; and (3) Winter 2021. Across an estimated 55.3–57.4 million Medicare beneficiaries, approximately one-fifth reported an inability to access at least one type of care at the onset of the pandemic. Significantly worse odds of an ability to get care across various time periods was observed among several priority conditions including immune disorders, cancer, depression, osteoporosis, diabetes, arthritis, and numerous cardiovascular and pulmonary conditions. Among those reporting an inability to access care, approximately one-third involved treatment of an ongoing condition, and under one-tenth involved prescription medications. To identify modifiable risk factors and to develop active interventions, future work should continue to assess the complex associations between outcomes, access to care, comorbidities, evolving healthcare infrastructures, computerization, and various public health initiatives.","PeriodicalId":72714,"journal":{"name":"COVID","volume":"16 36","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139168997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Video Games and the COVID-19 Pandemic: Virtual Worlds as New Playgrounds and Training Spaces 电子游戏与 COVID-19 大流行:虚拟世界作为新的游乐场和培训场所
Pub Date : 2023-12-19 DOI: 10.3390/covid4010001
Xosé Somoza Medina, Marta Somoza Medina
The COVID-19 pandemic forced the authorities to take an unprecedented measure in history: the house confinement of millions of people worldwide. Video games, especially open-world video games (OWVGs), became meeting spaces, a digital places to play, chat, learn and socialize due to the context of the health crisis, respecting the rules of social distancing. This article analyses the role of video games and, more specifically, OWVGs, as playgrounds and training spaces during the pandemic. Statistical data and analyses carried out by consulting companies and civil associations show the definitive insertion of these video games in our routine and social relations. The challenge is to take advantage of the skills and abilities that these video games develop within a new framework of individual and community learning. The conclusions of the research show that the virtual worlds of video games are for the new digital society, safe and comfortable meeting spaces, and that since the confinement, these digital places have greatly expanded their reach, previously only limited to the gamer community.
COVID-19 大流行迫使当局采取了一项史无前例的措施:在全球范围内对数以百万计的人进行软禁。电子游戏,尤其是开放世界电子游戏(OWVGs),在健康危机的背景下成为了聚会空间,成为了玩耍、聊天、学习和社交的数字场所,同时也尊重了社会距离规则。本文分析了电子游戏,更具体地说,OWVGs 在大流行病期间作为游戏场所和培训空间所发挥的作用。由咨询公司和民间协会进行的统计数据和分析表明,这些电子游戏已明确融入我们的日常工作和社会关系中。我们面临的挑战是如何在个人和社区学习的新框架内利用这些电子游戏所培养的技能和能力。研究结论表明,电子游戏的虚拟世界对于新的数字社会来说,是安全而舒适的聚会场所,而且自封闭以来,这些数字场所的影响范围大大扩展,以前只局限于游戏玩家群体。
{"title":"Video Games and the COVID-19 Pandemic: Virtual Worlds as New Playgrounds and Training Spaces","authors":"Xosé Somoza Medina, Marta Somoza Medina","doi":"10.3390/covid4010001","DOIUrl":"https://doi.org/10.3390/covid4010001","url":null,"abstract":"The COVID-19 pandemic forced the authorities to take an unprecedented measure in history: the house confinement of millions of people worldwide. Video games, especially open-world video games (OWVGs), became meeting spaces, a digital places to play, chat, learn and socialize due to the context of the health crisis, respecting the rules of social distancing. This article analyses the role of video games and, more specifically, OWVGs, as playgrounds and training spaces during the pandemic. Statistical data and analyses carried out by consulting companies and civil associations show the definitive insertion of these video games in our routine and social relations. The challenge is to take advantage of the skills and abilities that these video games develop within a new framework of individual and community learning. The conclusions of the research show that the virtual worlds of video games are for the new digital society, safe and comfortable meeting spaces, and that since the confinement, these digital places have greatly expanded their reach, previously only limited to the gamer community.","PeriodicalId":72714,"journal":{"name":"COVID","volume":" 25","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138963324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analytical Solution of the Susceptible-Infected-Recovered/Removed Model for the Not-Too-Late Temporal Evolution of Epidemics for General Time-Dependent Recovery and Infection Rates 针对一般时间依赖性恢复率和感染率的流行病不太晚时间演变的易感-感染-恢复-移除模型的分析解决方案
Pub Date : 2023-12-16 DOI: 10.3390/covid3120123
Reinhard Schlickeiser, Martin Kröger
The dynamical equations of the susceptible-infected-recovered/removed (SIR) epidemics model play an important role in predicting and/or analyzing the temporal evolution of epidemic outbreaks. Crucial input quantities are the time-dependent infection (a(t)) and recovery (μ(t)) rates regulating the transitions between the compartments S→I and I→R, respectively. Accurate analytical approximations for the temporal dependence of the rate of new infections J˚(t)=a(t)S(t)I(t) and the corresponding cumulative fraction of new infections J(t)=J(t0)+∫t0tdxJ˚(x) are available in the literature for either stationary infection and recovery rates or for a stationary value of the ratio k(t)=μ(t)/a(t). Here, a new and original accurate analytical approximation is derived for general, arbitrary, and different temporal dependencies of the infection and recovery rates, which is valid for not-too-late times after the start of the infection when the cumulative fraction J(t)≪1 is much less than unity. The comparison of the analytical approximation with the exact numerical solution of the SIR equations for different illustrative examples proves the accuracy of the analytical approach.
易感-感染-恢复-移除(SIR)流行病模型的动力学方程在预测和/或分析流行病爆发的时间演化方面发挥着重要作用。关键的输入量是与时间相关的感染率(a(t))和恢复率(μ(t)),它们分别调节 S→I 和 I→R 区间的转换。对于新感染率 J˚(t)=a(t)S(t)I(t)和相应的新感染累积分数 J(t)=J(t0)+∫t0tdxJ˚(x)的时间依赖性,文献中已有静态感染率和恢复率或比率 k(t)=μ(t)/a(t)的静态值的精确分析近似值。本文针对感染率和恢复率的一般、任意和不同的时间依赖性,推导出一种新的、独创的精确分析近似值,该近似值适用于感染开始后不太晚的时间,此时累积分数 J(t)≪1 远小于统一值。在不同的示例中,分析近似值与 SIR 方程的精确数值解的比较证明了分析方法的准确性。
{"title":"Analytical Solution of the Susceptible-Infected-Recovered/Removed Model for the Not-Too-Late Temporal Evolution of Epidemics for General Time-Dependent Recovery and Infection Rates","authors":"Reinhard Schlickeiser, Martin Kröger","doi":"10.3390/covid3120123","DOIUrl":"https://doi.org/10.3390/covid3120123","url":null,"abstract":"The dynamical equations of the susceptible-infected-recovered/removed (SIR) epidemics model play an important role in predicting and/or analyzing the temporal evolution of epidemic outbreaks. Crucial input quantities are the time-dependent infection (a(t)) and recovery (μ(t)) rates regulating the transitions between the compartments S→I and I→R, respectively. Accurate analytical approximations for the temporal dependence of the rate of new infections J˚(t)=a(t)S(t)I(t) and the corresponding cumulative fraction of new infections J(t)=J(t0)+∫t0tdxJ˚(x) are available in the literature for either stationary infection and recovery rates or for a stationary value of the ratio k(t)=μ(t)/a(t). Here, a new and original accurate analytical approximation is derived for general, arbitrary, and different temporal dependencies of the infection and recovery rates, which is valid for not-too-late times after the start of the infection when the cumulative fraction J(t)≪1 is much less than unity. The comparison of the analytical approximation with the exact numerical solution of the SIR equations for different illustrative examples proves the accuracy of the analytical approach.","PeriodicalId":72714,"journal":{"name":"COVID","volume":"15 s1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138967541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Two Sides of the COVID-19 Pandemic COVID-19 大流行的两面性
Pub Date : 2023-12-04 DOI: 10.3390/covid3120121
Ravinder Kumar, Vartika Srivastava, K. Nand
On 5 May 2023, the World Health Organization (WHO) officially declared the end of the coronavirus disease-19 (or COVID-19) pandemic. Even before the official announcement from the WHO, signs of recovery from the pandemic started appearing, especially after rapid worldwide vaccination. As society is getting back to its usual with each passing day, with the increasing socio-economic activities, discussion of the negative and positive outcomes of the COVID-19 pandemic remain the predominant topic of debate. Through this review, we discuss the bright side of the pandemic without undermining the pain and suffering everyone has gone through in this pandemic. The review also examined the painful side of the pandemic. Therefore, this review can be looked at as a comparison between this pandemic’s positive and negative effects. The review discussed aspects ranging from technological development, including mRNA-based vaccines, artificial intelligence-based screening, and telemedicine, to social behavior, from individual to global and from health to the environment. The review also examined the areas needing more attention for managing future pandemics. The review also highlighted what should be followed or continued for our preparedness for any possible pandemic. Toward the end, we also discussed how this pandemic has better prepared the world for future pandemics, as predicted by experts.
2023年5月5日,世界卫生组织(世卫组织)正式宣布2019冠状病毒病(COVID-19)大流行结束。甚至在世界卫生组织正式宣布之前,就已经出现了从大流行中复苏的迹象,特别是在全球迅速接种疫苗之后。随着社会日益恢复正常,社会经济活动日益增多,关于2019冠状病毒病大流行的消极和积极结果的讨论仍然是辩论的主要话题。通过这次审查,我们讨论了大流行的光明面,同时又不破坏每个人在这次大流行中所经历的痛苦和痛苦。审查还审查了大流行令人痛苦的一面。因此,本综述可被视为对本次大流行的积极影响和消极影响的比较。该评论讨论了从技术发展(包括基于mrna的疫苗、基于人工智能的筛查和远程医疗)到社会行为(从个人到全球、从健康到环境)的各个方面。该审查还审查了管理未来流行病需要更多关注的领域。审查还强调了我们为应对任何可能的大流行应采取或继续采取的措施。最后,我们还讨论了这次大流行如何使世界更好地为专家预测的未来大流行做好准备。
{"title":"The Two Sides of the COVID-19 Pandemic","authors":"Ravinder Kumar, Vartika Srivastava, K. Nand","doi":"10.3390/covid3120121","DOIUrl":"https://doi.org/10.3390/covid3120121","url":null,"abstract":"On 5 May 2023, the World Health Organization (WHO) officially declared the end of the coronavirus disease-19 (or COVID-19) pandemic. Even before the official announcement from the WHO, signs of recovery from the pandemic started appearing, especially after rapid worldwide vaccination. As society is getting back to its usual with each passing day, with the increasing socio-economic activities, discussion of the negative and positive outcomes of the COVID-19 pandemic remain the predominant topic of debate. Through this review, we discuss the bright side of the pandemic without undermining the pain and suffering everyone has gone through in this pandemic. The review also examined the painful side of the pandemic. Therefore, this review can be looked at as a comparison between this pandemic’s positive and negative effects. The review discussed aspects ranging from technological development, including mRNA-based vaccines, artificial intelligence-based screening, and telemedicine, to social behavior, from individual to global and from health to the environment. The review also examined the areas needing more attention for managing future pandemics. The review also highlighted what should be followed or continued for our preparedness for any possible pandemic. Toward the end, we also discussed how this pandemic has better prepared the world for future pandemics, as predicted by experts.","PeriodicalId":72714,"journal":{"name":"COVID","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138602979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Analyzing County-Level COVID-19 Vaccination Rates in Texas: A New Lindley Regression Model 分析得克萨斯州县级 COVID-19 疫苗接种率:新的林德利回归模型
Pub Date : 2023-12-04 DOI: 10.3390/covid3120122
Nicollas S. S. da Costa, Maria do Carmo S. de Lima, G. Cordeiro
This work aims to study the factors that explain the COVID-19 vaccination rate through a generalized odd log-logistic Lindley regression model with a shape systematic component. To accomplish this, a dataset of the vaccination rate of 254 counties in the state of Texas, US, was used, and simulations were performed to investigate the accuracy of the maximum likelihood estimators in the proposed regression model. The mathematical properties investigated provide important information about the characteristics of the distribution. Diagnostic analysis and deviance residuals are addressed to examine the fit of the model. The proposed model shows effectiveness in identifying the key variables of COVID-19 vaccination rates at the county level, which can contribute to improving vaccination campaigns. Moreover, the findings corroborate with prior studies, and the new distribution is a suitable alternative model for future works on different datasets.
本工作旨在通过具有形状系统成分的广义奇对数-逻辑林德利回归模型研究解释COVID-19疫苗接种率的因素。为了实现这一目标,使用了美国德克萨斯州254个县的疫苗接种率数据集,并进行了模拟,以调查所提出的回归模型中最大似然估计量的准确性。所研究的数学性质提供了有关分布特征的重要信息。诊断分析和偏差残差处理,以检查模型的拟合。该模型在确定县一级COVID-19疫苗接种率的关键变量方面显示出有效性,这有助于改进疫苗接种活动。此外,这些发现证实了先前的研究,并且新的分布是未来在不同数据集上工作的合适替代模型。
{"title":"Analyzing County-Level COVID-19 Vaccination Rates in Texas: A New Lindley Regression Model","authors":"Nicollas S. S. da Costa, Maria do Carmo S. de Lima, G. Cordeiro","doi":"10.3390/covid3120122","DOIUrl":"https://doi.org/10.3390/covid3120122","url":null,"abstract":"This work aims to study the factors that explain the COVID-19 vaccination rate through a generalized odd log-logistic Lindley regression model with a shape systematic component. To accomplish this, a dataset of the vaccination rate of 254 counties in the state of Texas, US, was used, and simulations were performed to investigate the accuracy of the maximum likelihood estimators in the proposed regression model. The mathematical properties investigated provide important information about the characteristics of the distribution. Diagnostic analysis and deviance residuals are addressed to examine the fit of the model. The proposed model shows effectiveness in identifying the key variables of COVID-19 vaccination rates at the county level, which can contribute to improving vaccination campaigns. Moreover, the findings corroborate with prior studies, and the new distribution is a suitable alternative model for future works on different datasets.","PeriodicalId":72714,"journal":{"name":"COVID","volume":"1 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138603963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Incorporating Virtual Problem-Based Learning in Instrumental Chemistry during the COVID-19 Pandemic 在 COVID-19 大流行期间将基于问题的虚拟学习融入仪器化学中
Pub Date : 2023-11-29 DOI: 10.3390/covid3120120
Xiaoping Li, Ying Guo, Simon M. Mwongela, Michael Kirberger
The COVID-19 pandemic has presented substantial challenges to higher education, leading to economic loss and disruptions in STEM courses. This study addresses these issues through the successful implementation of a problem-based learning research project within the Instrumental Chemistry course at Georgia Gwinnett College (GGC). Focused on instrumental chemistry, the project spans various categories, requiring students to propose solutions to real-case scenarios using specific analytical instruments. Despite the shift to a hybrid teaching modality, students exhibited commendable preparation and investigation skills, as demonstrated by their projects. Assessment data, including a student survey and written report evaluations, underscore significant skill improvements in literature survey, instrument selection, experimental design, and data analysis. This problem-based learning approach not only mitigated the disruptions caused by the pandemic but also fostered enhanced capabilities and motivation among students. The study’s findings contribute insights into the adaptability and effectiveness of problem-based learning in analytical chemistry education within a hybrid teaching framework, offering valuable considerations for future educational strategies in STEM disciplines and beyond.
COVID-19 大流行给高等教育带来了巨大挑战,导致经济损失和 STEM 课程中断。本研究通过在佐治亚州格威内特学院(GGC)的仪器化学课程中成功实施基于问题的学习研究项目来解决这些问题。该项目以仪器化学为重点,横跨多个类别,要求学生使用特定的分析仪器针对实际情况提出解决方案。尽管转向了混合教学模式,但学生们在项目中表现出了值得称道的准备和探究能力。包括学生调查和书面报告评估在内的评估数据表明,学生在文献调查、工具选择、实验设计和数据分析方面的技能有了显著提高。这种基于问题的学习方法不仅减轻了大流行病造成的干扰,还提高了学生的能力和积极性。研究结果有助于深入了解混合教学框架下基于问题的学习在分析化学教育中的适应性和有效性,为未来 STEM 学科及其他学科的教育策略提供了有价值的思考。
{"title":"Incorporating Virtual Problem-Based Learning in Instrumental Chemistry during the COVID-19 Pandemic","authors":"Xiaoping Li, Ying Guo, Simon M. Mwongela, Michael Kirberger","doi":"10.3390/covid3120120","DOIUrl":"https://doi.org/10.3390/covid3120120","url":null,"abstract":"The COVID-19 pandemic has presented substantial challenges to higher education, leading to economic loss and disruptions in STEM courses. This study addresses these issues through the successful implementation of a problem-based learning research project within the Instrumental Chemistry course at Georgia Gwinnett College (GGC). Focused on instrumental chemistry, the project spans various categories, requiring students to propose solutions to real-case scenarios using specific analytical instruments. Despite the shift to a hybrid teaching modality, students exhibited commendable preparation and investigation skills, as demonstrated by their projects. Assessment data, including a student survey and written report evaluations, underscore significant skill improvements in literature survey, instrument selection, experimental design, and data analysis. This problem-based learning approach not only mitigated the disruptions caused by the pandemic but also fostered enhanced capabilities and motivation among students. The study’s findings contribute insights into the adaptability and effectiveness of problem-based learning in analytical chemistry education within a hybrid teaching framework, offering valuable considerations for future educational strategies in STEM disciplines and beyond.","PeriodicalId":72714,"journal":{"name":"COVID","volume":"129 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139212777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Eating Habits and Mental Health of College Students in Japan during the COVID-19 Pandemic COVID-19 大流行期间日本大学生的饮食习惯与心理健康
Pub Date : 2023-11-26 DOI: 10.3390/covid3120119
Tomoko Imoto, Yuichiro Hoshino, Yoshiyuki Sato, Yusuke Ohsaki, Hitoshi Shirakawa
While the relationship between eating habits and mental health has been widely studied, there is limited research focusing on college students during emergency situations such as pandemics. We conducted an online questionnaire survey to address this gap. Clustering analysis was applied to identify students’ eating habits, which are possibly more complex than traditional eating habits. Based on the identified eating habits, the students were separated into five groups. We evaluated the relationship between eating habits and mental health in these five groups using University Personality Inventory scores. Based on the results, the largest group—corresponding to slightly less than half of the participants—had the highest vegetable intake and mental health levels. This aligns with findings from numerous prior studies. However, our novel discovery was the presence of another group within those with higher vegetable intake, who had lower levels of mental health. Conversely, a group with lower vegetable intake had higher levels of mental health; remarkably, students in this group frequently consumed soft drinks, suggesting that, during the COVID-19 emergency, indulgent food and drinks may have played a role in enhancing mental health.
虽然饮食习惯与心理健康之间的关系已被广泛研究,但针对大学生在大流行病等紧急情况下的研究却很有限。针对这一空白,我们开展了一项在线问卷调查。我们采用聚类分析来识别学生的饮食习惯,这些饮食习惯可能比传统的饮食习惯更为复杂。根据确定的饮食习惯,学生被分为五组。我们使用《大学人格量表》的评分来评估这五个组的饮食习惯与心理健康之间的关系。结果显示,最大的一组--相当于略少于一半的参与者--蔬菜摄入量和心理健康水平最高。这与之前多项研究的结果一致。然而,我们的新发现是,在蔬菜摄入量较高的人群中还存在另一个群体,他们的心理健康水平较低。相反,蔬菜摄入量较低的一组学生的心理健康水平较高;值得注意的是,这组学生经常饮用软饮料,这表明在 COVID-19 紧急事件期间,放纵的食物和饮料可能起到了促进心理健康的作用。
{"title":"Eating Habits and Mental Health of College Students in Japan during the COVID-19 Pandemic","authors":"Tomoko Imoto, Yuichiro Hoshino, Yoshiyuki Sato, Yusuke Ohsaki, Hitoshi Shirakawa","doi":"10.3390/covid3120119","DOIUrl":"https://doi.org/10.3390/covid3120119","url":null,"abstract":"While the relationship between eating habits and mental health has been widely studied, there is limited research focusing on college students during emergency situations such as pandemics. We conducted an online questionnaire survey to address this gap. Clustering analysis was applied to identify students’ eating habits, which are possibly more complex than traditional eating habits. Based on the identified eating habits, the students were separated into five groups. We evaluated the relationship between eating habits and mental health in these five groups using University Personality Inventory scores. Based on the results, the largest group—corresponding to slightly less than half of the participants—had the highest vegetable intake and mental health levels. This aligns with findings from numerous prior studies. However, our novel discovery was the presence of another group within those with higher vegetable intake, who had lower levels of mental health. Conversely, a group with lower vegetable intake had higher levels of mental health; remarkably, students in this group frequently consumed soft drinks, suggesting that, during the COVID-19 emergency, indulgent food and drinks may have played a role in enhancing mental health.","PeriodicalId":72714,"journal":{"name":"COVID","volume":"355 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139235472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
COVID
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1