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Can clinical parameters at admission predict severity and intensive care unit mortality outcomes in patients with COVID-19? 入院时的临床参数能否预测COVID-19患者的严重程度和重症监护病房死亡率结局?
Pub Date : 2023-07-01 DOI: 10.4103/cmi.cmi_6_23
KFibi Ninan, R. Iyadurai, Justin K Varghese, JJonathan Arul Jeevan, Karthik Gunasekaran, R. Karuppusami, B. Chacko, K. Johnson, Amit Mandal, NivinStanley David
Background: COVID-19 acute respiratory distress syndrome (ARDS) is associated with high morbidity and mortality. Identification of clinical prognostic factors at admission is crucial in the triage and therapeutic selection of patients in resource-poor settings. The study was done to identify clinical parameters at admission to prognosticate patients who required intensive care unit (ICU) admission. Methods: In this retrospective study, the clinical parameters and outcomes of critically ill patients admitted from a single medical unit during the second wave of COVID-19 were studied. Patients were categorized as survivors and nonsurvivors. Factors associated with mortality were explored using Fisher's exact and t-test as appropriate. Results: The study population included 62 patients with a male: female ratio of 43 (69.3%):19 (30.7%) with a mean (standard deviation [SD]) age of 50.97 (±9.9) years. The mean (SD) O2 saturation was 82% (±10%) and median (interquartile range) PaO2/FiO2 ratio was 161 (89–214) on arrival to the emergency department. Forty-two (66%) required mechanical ventilation and the mean (SD) duration of hospital stay was 20 (±15) days. Thirty-six patients died, and the overall mortality was 58.1%. Increasing age, low SpO2 at presentation to the hospital, and need for mechanical ventilation were noted to be independent predictors of mortality with an odds ratio of 5.1 (95% confidence interval) (1.61–16.2) (P = 0.006) and 25 (3.70–180.19) (P = 0.001), respectively. Admission respiratory rate >36/min (P = 0.009) and SpO2 ≤83% (P = 0.001) were predictive of increased mortality among ICU patients. Conclusion: Low SpO2 at presentation (<83%), high respiratory rate (>36/min), and requirement of mechanical ventilation were strong predictors of mortality in patients admitted to ICU with COVID-19 ARDS.
背景:COVID-19急性呼吸窘迫综合征(ARDS)具有较高的发病率和死亡率。在资源贫乏的情况下,入院时确定临床预后因素对患者的分诊和治疗选择至关重要。该研究的目的是确定入院时的临床参数,以预测需要重症监护病房(ICU)入院的患者。方法:回顾性分析第二波新冠肺炎疫情期间同一医疗单位收治的危重患者的临床参数和转归。患者分为幸存者和非幸存者。采用Fisher精确检验和t检验探讨与死亡率相关的因素。结果:纳入研究人群62例,男女比例为43(69.3%):19(30.7%),平均(标准差[SD])年龄为50.97(±9.9)岁。到达急诊科时,平均(SD) O2饱和度为82%(±10%),中位数(四分位间距)PaO2/FiO2比值为161(89-214)。42例(66%)需要机械通气,平均(SD)住院时间为20(±15)天。死亡36例,总死亡率为58.1%。年龄增加、入院时SpO2低和需要机械通气是死亡率的独立预测因素,比值比分别为5.1(95%可信区间)(1.61-16.2)(P = 0.006)和25 (3.70-180.19)(P = 0.001)。入院呼吸率>36/min (P = 0.009)和SpO2≤83% (P = 0.001)可预测ICU患者死亡率升高。结论:入院时低SpO2 (36/min)和机械通气需求是ICU收治的COVID-19 ARDS患者死亡率的重要预测因素。
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引用次数: 0
Program evaluation in the field of medical education: Need and approaches 医学教育领域的项目评估:需求和方法
Pub Date : 2023-07-01 DOI: 10.4103/cmi.cmi_31_23
S. Shrivastava, P. Shrivastava
Program evaluation is a must for medical education programs and requires the involvement of all the concerned stakeholders. It is important to note that the general aim behind any educational program is to look for a change, and thus, program evaluation should look to identify whether the change has occurred or not. In fact, a systematically performed program evaluation provides the organizers with the desired evidence about the quality of the program, accountability, and its sustainability. In conclusion, the program evaluation in the field of medical education is a vital cog in the entire cycle of development and implementation. Thus, it is extremely important to give due attention to the evaluation component and develop the framework for the same right at the time of the planning phase of the program.
项目评估是医学教育项目必须进行的,需要所有相关利益相关者的参与。重要的是要注意,任何教育计划背后的一般目标都是寻找变化,因此,计划评估应该寻找确定是否发生了变化。事实上,系统地执行项目评估为组织者提供了关于项目质量、责任和可持续性的所需证据。总之,医学教育领域的项目评估是整个发展和实施周期中至关重要的一环。因此,在方案的规划阶段,对评估部分给予应有的重视并为同样的权利制定框架是极其重要的。
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引用次数: 0
Assessment of risk factors and angiographic profile in left main coronary artery disease: An observational study 左主干冠状动脉疾病的危险因素和血管造影评估:一项观察性研究
Pub Date : 2023-07-01 DOI: 10.4103/cmi.cmi_127_22
R. Singh, A. Kandoria, P. Negi
Background: Diagnostic and management challenges with unpredictable angiographic presentations are encountered in left main coronary artery disease (LMCAD) patients. Therefore, this study was designed to evaluate the prevalence, risk factors, angiographic profile, and outcomes associated with LMCAD at 6-month follow-up. Materials and Methods: This was a prospective observational study where a total of 1474 patients undergoing coronary angiography were enrolled between March 2018 and August 2019. Demographic details, physical examination, and routine biochemical investigations were reported. Obstructive LMCAD patients were managed either with percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) according to syntax score, and outcomes were recorded at 6-month follow-up. Results: The mean age of the overall study population (1474 patients) was 59 ± 8.1 years with male 959 (65%) preponderance. Obstructive LMCAD was observed in 103 (6%) patients. Smoking was the prime risk factor associated with obstructive LMCAD observed among 58 (56%) patients followed by hypertension in 45 (43%), dyslipidemia in 42 (40%), obesity in 26 (25%), and diabetes mellitus in 23 (22%) patients. Among 41 (40%) obstructive LMCAD patients, non-ST-elevation myocardial infarction/unstable angina was the major presentation. The majorly affected target vessels were left anterior descending artery (100%) and left circumflex artery (80%) among 103 and 83 patients, respectively. Triple-vessel disease was predominantly observed among 63 (62%) obstructive LMCAD patients. PCI and CABG were performed in 19 (18.4%) and 27 (26.2%) patients with a mean syntax score of 20 and 31, respectively. Conclusion: Smoking, advanced age, diabetes, and dyslipidemia were significantly associated risk factors of LMCAD.
背景:左主干冠状动脉疾病(LMCAD)患者的诊断和治疗面临着难以预测的血管造影表现的挑战。因此,本研究旨在评估6个月随访时LMCAD的患病率、危险因素、血管造影特征和相关结果。材料和方法:这是一项前瞻性观察研究,在2018年3月至2019年8月期间,共有1474名接受冠状动脉造影的患者入组。报告了人口统计细节、体格检查和常规生化调查。根据句法评分对梗阻性LMCAD患者进行经皮冠状动脉介入治疗(PCI)或冠状动脉旁路移植术(CABG),随访6个月记录结果。结果:总体研究人群(1474例)的平均年龄为59±8.1岁,男性959(65%)居多。103例(6%)患者出现阻塞性LMCAD。在58例(56%)患者中,吸烟是与阻塞性LMCAD相关的主要危险因素,其次是高血压45例(43%),血脂异常42例(40%),肥胖26例(25%),糖尿病23例(22%)。在41例(40%)梗阻性LMCAD患者中,非st段抬高型心肌梗死/不稳定型心绞痛是主要表现。103例患者以左前降支为主(100%),83例患者以左旋支为主(80%)。63例(62%)阻塞性LMCAD患者以三支血管病变为主。分别有19例(18.4%)和27例(26.2%)患者行PCI和CABG,平均句法评分分别为20分和31分。结论:吸烟、高龄、糖尿病、血脂异常是LMCAD的危险因素。
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引用次数: 0
Diffusion-weighted imaging in differentiating benign versus malignant lymphadenopathy: A cross-sectional study 弥散加权成像鉴别良恶性淋巴结病的横断面研究
Pub Date : 2023-04-01 DOI: 10.4103/cmi.cmi_86_22
K. Sumith, T. Vinoth, P. Jenikar, M. Kumar
Background: Lymphadenopathy requires differentiation into benign and malignant for appropriate management. The current study was done to find out if diffusion-weighted images and apparent diffusion coefficient (ADC) will be able to differentiate benign from malignant cervical lymphadenopathy. Methods: This cross-sectional study was done in the Department of Radiology at Sri Ramachandra Medical College from April 2016 to August 2018. A total of 54 patients with a history of lymphadenopathy were recruited. Histopathological examination (HPE) and magnetic resonance imaging were done for all patients after a complete history and physical examination. The ADC was correlated with HPE in differentiating benign and malignant lymphadenopathy. Results: Majority (46.30%) were in the age group of 51 years and above. Twenty-eight (51.85%) had benign, whereas 26 (48.15%) had malignant lesions. There was a statistically significant difference between the nature of the lesion in ADC value ([× 10–3 mm2/s] [P < 0.001]). The ADC had good predictive validity in predicting malignancy, as indicated by the area under the curve of 0.904 (95% confidence interval 0.821 to 0.987, P < 0.001). Conclusion: ADC values can be used as a complementary tool in assessing the malignant potential of lymph nodes in various conditions and hence play an essential role in the further course of management.
背景:淋巴结病需要区分良恶性,以便进行适当的治疗。本研究旨在探讨弥散加权图像和表观弥散系数(ADC)是否能够区分宫颈淋巴结病的良恶性。方法:本横断面研究于2016年4月至2018年8月在室利罗摩犍陀罗医学院放射科进行。共招募了54例有淋巴结病病史的患者。在完整的病史和体格检查后,对所有患者进行组织病理学检查(HPE)和磁共振成像。ADC与HPE在鉴别良恶性淋巴结病变上有相关性。结果:51岁及以上年龄组占多数(46.30%)。良性28例(51.85%),恶性26例(48.15%)。病变性质间ADC值差异有统计学意义([× 10-3 mm2/s] [P < 0.001])。ADC对恶性肿瘤有较好的预测效度,曲线下面积为0.904(95%可信区间为0.821 ~ 0.987,P < 0.001)。结论:ADC值可作为评估各种情况下淋巴结恶性潜能的辅助工具,在进一步的治疗过程中发挥重要作用。
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引用次数: 0
Progression in refractive error in children during COVID-19 pandemic due to virtual classes: A cohort study 虚拟课堂导致COVID-19大流行期间儿童屈光不正进展:一项队列研究
Pub Date : 2023-04-01 DOI: 10.4103/cmi.cmi_108_22
Shovna Dash, G. Mohanty, Soumya Mohanty, N. Mohakud
Background: The pandemic resulted in increased screen hours in children due to virtual education. The rate of progression of myopia was noticed to be remarkable in the past 2 years. This study is an endeavor to study the effect of increased screen hours during COVID home confinement on the degree of progression of myopia in school children and to evaluate the difference in change of refractive errors with a variation in the screen size of the digital device used. Methods: This was prospective observational study with a retrospective comparison arm, wherein 70 school children (140 eyes) aged 4–18 years were subjected to a cycloplegic refraction test. The difference in spherical equivalent refraction from the year 2018 to 19 was compared with that of the difference observed in the pandemic year 2019–2020. A statistical analysis was also made regarding the correlation of variation in refraction between the different genders, age groups, and screen sizes. Results: Of the 70 children, 29 (41.42%) were girls and 41 (58.58%) were boys. The gadgets being used vary from mobiles to laptops, and the range of screens and sizes varies from 100 cm2 to 500 cm2. Similarly, the duration of device use varied from 4 to 8 h. For 2018, the mean value of the spherical equivalent was −1.69 ± 1.42, for 2019 it was −1.92 ± 1.50 and for 2020 the mean value was −2.61 ± 1.47 for the right eye. The mean value of the spherical equivalent for the left eye in 2018 was −1.68 ± 1.51, in 2019 the value was −1.87 ± 1.58, and in 2020, the mean value was −2.73 ± 1.78. Conclusions: Increased exposure to digital devices during the COVID-19 period has a role to play in the progression of myopia in school-aged children.
背景:由于虚拟教育,大流行导致儿童屏幕时间增加。在过去的2年中,近视的进展速度显著。本研究旨在研究COVID家庭隔离期间增加屏幕时间对学龄儿童近视进展程度的影响,并评估使用的数字设备屏幕尺寸变化对屈光不正变化的影响。方法:这是一项前瞻性观察性研究,回顾性比较组,其中70名4-18岁的学童(140眼)接受了单眼麻痹性屈光测试。将2018年至2019年的球面等效折射差异与2019-2020年大流行年观察到的差异进行了比较。统计分析了不同性别、年龄、屏幕尺寸对折射变化的相关性。结果:70例患儿中,女孩29例(41.42%),男孩41例(58.58%)。使用的设备从手机到笔记本电脑各不相同,屏幕和尺寸从100平方厘米到500平方厘米不等。同样,设备使用的持续时间从4到8小时不等。2018年,右眼的球形当量平均值为- 1.69±1.42,2019年为- 1.92±1.50,2020年的平均值为- 2.61±1.47。2018年左眼球形当量均值为- 1.68±1.51,2019年均值为- 1.87±1.58,2020年均值为- 2.73±1.78。结论:在2019冠状病毒病期间,数字设备的暴露增加与学龄儿童近视的进展有关。
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引用次数: 0
Clinical, uropathogenic, and radiological profile of culture-positive urinary tract infections in children below 18 months of age 18个月以下儿童培养阳性尿路感染的临床、尿路病原学和放射学分析
Pub Date : 2023-04-01 DOI: 10.4103/cmi.cmi_76_22
Sachin George, R. Deepthi, Georgie Mathew, Jude Prakash, Dona Maria, I. Agarwal
Background: Urinary tract infections (UTIs) are common in children and have the risk of renal scarring. To better identify this at risk group, the following study was carried out to analyze the clinical profile of children below 18 months of age with culture-positive UTI and the outcome of radiological investigations. The primary objective was to assess the clinical profile of culture-positive UTI children and diagnostic yield and correlation between radiological tests. The secondary objectives were to assess the prevalent uropathogens and their antibiogram. Materials and Methods: For this retrospective study, clinical details regarding radiological investigations, prevalent uropathogens and antibiograms, common antibiotics used in treatment, and uroprophylaxis were obtained through electronic medical records in children <18 months of age admitted with culture-positive UTI. Results: In 225 children seen over a period of 36 months, a slight male predominance (56%) was observed. Ultrasonography (USG) was done in nearly all children, micturating cystourethrography (MCU) was performed in only 40% of patients, dimercaptosuccinic acid (DMSA), performed after 6 months of the index UTI, in one-fifths of the patients. All three investigations were performed in one out of six children. USG and MCU used in combination detected the highest number of significant abnormalities (39%) compared to USG and DMSA (32%). Escherichia coli was the predominant uropathogen identified. Significant meropenem resistance (52%) was observed in the community-acquired UTI. Conclusion: The evaluation and follow-up of infants and young children with UTI show inadequate radiological evaluation, which could increase the risk of undetected and untreated renal sequelae.
背景:尿路感染(uti)在儿童中很常见,并有肾脏瘢痕形成的风险。为了更好地识别这一高危人群,进行了以下研究,分析了18个月以下尿路感染培养阳性儿童的临床资料和放射学调查结果。主要目的是评估培养阳性尿路感染儿童的临床特征、诊断率和放射检查之间的相关性。次要目的是评估流行的尿路病原体及其抗生素谱。材料和方法:本回顾性研究通过电子病历获取18月龄以下尿路感染培养阳性儿童的影像学检查、尿路常见病原体和抗生素图、常用抗生素治疗和尿路预防等临床细节。结果:在36个月的225例患儿中,观察到轻微的男性优势(56%)。几乎所有儿童都进行了超声检查(USG),只有40%的患者进行了排尿膀胱尿道造影(MCU),五分之一的患者在尿路感染指数6个月后进行了二巯基琥珀酸(DMSA)检查。所有三项调查都是在六分之一的儿童中进行的。与USG和DMSA(32%)相比,USG和MCU联合使用检测到的显著异常数量最多(39%)。尿路病原菌以大肠杆菌为主。在社区获得性UTI中观察到显著的美罗培南耐药性(52%)。结论:婴幼儿尿路感染的评价与随访显示放射学评价不充分,可能增加未被发现和未经治疗的肾后遗症的风险。
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引用次数: 0
Approach to reducing the burden of pesticide poisoning and improving outcomes in patients with deliberate self-harm 减轻农药中毒负担和改善故意自残患者预后的方法
Pub Date : 2023-04-01 DOI: 10.4103/cmi.cmi_13_23
J. Peter, A. Mampilly
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引用次数: 0
Accuracy of ultrasound and magnetic resonance imaging in predicting placenta accreta: A retrospective study 超声和磁共振成像预测胎盘增生的准确性:回顾性研究
Pub Date : 2023-04-01 DOI: 10.4103/cmi.cmi_85_22
P. Jaisankar, M. Kumar, R. Gowtham, T. Vinoth
Background: Placenta accreta can cause significant morbidity and mortality in pregnant women. Timely diagnosis is essential for management. This study aimed to evaluate the accuracy of ultrasound (USG) and magnetic resonance imaging (MRI) techniques in predicting placenta accreta. Methodology: A retrospective study was conducted at our institute from April 2014 to September 2017. Pregnant women with suspected placenta accrete were recruited for the study. Medical records of pregnant women who have undergone both USG and prenatal MRI were included. The accuracy of USG and MRI was compared. Results: Among the 56 cases evaluated in the study, the diagnosis was accurately obtained with ultrasonography in 75% of cases and with MRI in 68.51% of cases. Sensitivity for placenta accreta was 97.29% for USG and 78.37% for MRI. Specificities were 31.57% for USG and 47.05% for MRI. The positive predictive value was 73.46% for USG and 76.31% for MRI. Conclusion: Although a definite demarcation could not be obtained from the sensitivity, specificity, and positive predictive value of the placenta accrete with ultrasonography and MRI, the diagnostic accuracy may be taken as a definite pointer. Hence, ultrasonography remains the mainstay of diagnosis for placenta accrete; and MRI can be considered complementary in cases with few USG signs.
背景:妊娠妇女胎盘增生可引起显著的发病率和死亡率。及时诊断对治疗至关重要。本研究旨在评估超声(USG)和磁共振成像(MRI)技术预测胎盘增生的准确性。方法:回顾性研究于2014年4月至2017年9月在我院进行。研究招募了疑似胎盘增生的孕妇。包括同时进行USG和产前MRI的孕妇的医疗记录。比较USG和MRI的准确性。结果:本组56例病例中,超声诊断正确率为75%,MRI诊断正确率为68.51%。USG和MRI对胎盘增生的敏感性分别为97.29%和78.37%。USG和MRI的特异性分别为31.57%和47.05%。USG阳性预测值为73.46%,MRI阳性预测值为76.31%。结论:虽然超声和MRI对胎盘积液的敏感性、特异性和阳性预测值尚不能明确划分,但其诊断准确性可作为明确的指标。因此,超声检查仍然是诊断胎盘增生的主要手段;在USG征象较少的病例中,MRI可作为补充。
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引用次数: 0
Utilizing the community as a learning resource in the training of undergraduate medical students 利用社区学习资源培养医学本科学生
Pub Date : 2023-04-01 DOI: 10.4103/cmi.cmi_125_22
S. Shrivastava, P. Shrivastava
The kind and range of attributes that an undergraduate medical student should acquire by the time of completion of their training are extensive. The exposure of undergraduate medical students to the local community during the training period carries immense significance in the learning curve of the students. The exposure to community as a learning resource satisfies multiple principles of adult learning, as medical students can be actively engaged in the learning process, wherein they have to play a specific role and the learning happens across all the learning domains and does not remain restricted to the cognitive domain alone. In conclusion, the use of community as a learning resource for facilitating the training of medical students has been linked with multiple benefits. However, it is quite essential that potential challenges should be identified and accordingly preparation is done by the concerned departments to ensure the attainment of learning objectives and avoid rejection from the community.
医本科生在完成培训时应具备的素质种类和范围是广泛的。本科医学生在实习期间接触当地社区对学生的学习曲线具有重要意义。接触社区作为一种学习资源满足了成人学习的多种原则,因为医学生可以积极参与学习过程,在学习过程中,他们必须扮演特定的角色,学习发生在所有学习领域,而不仅仅局限于认知领域。总之,利用社区作为一种学习资源,促进医学生的培训,具有多种好处。然而,有关部门必须识别潜在的挑战,并做好相应的准备,以确保达到学习目标,避免被社会排斥。
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引用次数: 0
Predictors of recurrence in oral cavity cancer with clear surgical margins 明确手术切缘的口腔癌复发的预测因素
Pub Date : 2023-04-01 DOI: 10.4103/cmi.cmi_70_22
Mansi Agrawal, V. Konduru, A. Tirkey, Riju Jeyashant, Philip George, D. Philip, C. Setty, Kiran Devarkonda
Introduction: Oral cancers recur in a significant proportion of patients, in spite of aggressive treatment strategies. The presence of a clear surgical margin is an important predictor of recurrent disease, among others. Since oral cancers often recur in the absence of compromised margins, there is a need to study the factors affecting recurrence and overall survival outcomes where clear surgical margins have been achieved during upfront surgery. This study attempts to identify the significant predictors of locoregional recurrence in oral squamous cell carcinoma (OSCC) with pathologically clear surgical margins. Methodology: This retrospective study was done to study the clinicopathological parameters associated with recurrence of oral cavity squamous cell carcinoma (SCC) in patients with clear surgical margins operated in our unit between January 2010 and December 2015. A total of 526 cases of oral cavity SCC were analyzed and records of 160 cases with clear surgical margins were reviewed for clinical details, histopathological data, and follow-up status. Age, gender, subsite, T–N clinical and pathological staging, tumor depth of invasion, grade of differentiation, lymphovascular invasion, perineural spread, adjuvant therapy, and recurrence details were analyzed. Results: Lymphovascular Invasion was found to be a significant predictor for local recurrence in OSCC in both univariate and multivariate analysis. Median recurrence-free survival was 53.6 months. Conclusion: Despite the best efforts of the surgeon in obtaining adequate tumor-free margins and the most comprehensive adjuvant treatment, recurrence patterns in oral cancers continue to defy accurate prediction. Lymphovascular invasion could be an important predictor of recurrence for oral cavity cancers in patients with clear surgical margins that require aggressive management.
尽管采取了积极的治疗策略,口腔癌仍有很大比例的患者复发。除其他外,清晰的手术切缘是疾病复发的重要预测因素。由于口腔癌经常在边缘未受损的情况下复发,因此有必要研究在前期手术中获得明确手术边缘的情况下影响复发和总体生存结果的因素。本研究旨在确定病理上手术边缘清晰的口腔鳞状细胞癌(OSCC)局部复发的重要预测因素。方法:本回顾性研究旨在研究2010年1月至2015年12月在我单位手术边缘清晰的口腔鳞状细胞癌(SCC)患者复发的临床病理参数。我们对526例口腔鳞状细胞癌进行了分析,并回顾了160例手术边缘清晰的病例的临床资料、组织病理学资料和随访情况。分析年龄、性别、亚位、T-N临床病理分期、肿瘤浸润深度、分化程度、淋巴血管浸润、神经周围扩散、辅助治疗、复发细节。结果:淋巴血管浸润在单因素和多因素分析中都被发现是OSCC局部复发的重要预测因素。中位无复发生存期为53.6个月。结论:尽管外科医生尽了最大的努力获得足够的无肿瘤边缘和最全面的辅助治疗,口腔癌的复发模式仍然无法准确预测。淋巴血管侵袭可能是口腔癌复发的重要预测因素,患者手术边缘清晰,需要积极的治疗。
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引用次数: 0
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Current medical issues
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