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What is a clinical trial protocol? 什么是临床试验方案?
Pub Date : 2010-04-01
Andrea Cipriani, Corrado Barbui

Trial protocols are documents that describe the objectives, design, methodology, statistical considerations and aspects related to the organization of clinical trials. Trial protocols provide the background and rationale for conducting a study, highlighting specific research questions that are addressed, and taking into consideration ethical issues. Trial protocols must meet a standard that adheres to the principles of Good Clinical Practice, and are used to obtain ethics approval by local Ethics Committees or Institutional Review Boards.

试验方案是描述临床试验的目标、设计、方法、统计考虑和组织相关方面的文件。试验方案提供了开展研究的背景和基本原理,突出了要解决的具体研究问题,并考虑到伦理问题。试验方案必须符合符合良好临床实践原则的标准,并用于获得当地伦理委员会或机构审查委员会的伦理批准。
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引用次数: 0
Service user perspectives on the impact of a mental illness diagnosis. 服务使用者对精神疾病诊断影响的看法。
Pub Date : 2010-04-01 DOI: 10.1017/s1121189x00000841
Diana Rose, Graham Thornicroft

Aim: To provide a conceptual and practical analysis of the impacts of mental health diagnoses on consumers and to consider how service users might contribute to the new psychiatric classifications currently being drawn up.

Methods: A search was carried out revealing a very sparse literature on this topic. Consultations with service users were conducted and the views of experts sought.

Results: Diagnosis is important as it marks the formal status of psychiatric patient being conferred. Consumers react differently, and often, negatively to this. Stigma can follow from a diagnosis. The process of giving a diagnosis can range from one of negotiation and taking the person's strengths into account to the blunt allocation of an unwanted label. Consumers can be reduced to their diagnosis so it becomes their whole personhood and this can have an effect on their sense of self. However, consumers are not passive victims and have their own strategies for dealing with these issues.

Conclusion: Consumers can use these experiences to make contributions to the new diagnostic classification systems and to future research.

目的:对心理健康诊断对消费者的影响进行概念和实践分析,并考虑服务使用者如何有助于目前正在起草的新的精神病学分类。方法:进行检索,发现关于该主题的文献非常稀少。与服务使用者进行了协商,并征求了专家的意见。结果:诊断是重要的,因为它标志着精神病人的正式地位被授予。消费者对此的反应不同,而且往往是消极的。病耻感可以从诊断中产生。做出诊断的过程可以是协商,考虑到病人的长处,也可以是直接给病人贴上不想要的标签。消费者可以被简化为他们的诊断,因此它成为他们的整个人格,这可以对他们的自我意识产生影响。然而,消费者不是被动的受害者,他们有自己的策略来处理这些问题。结论:消费者可以利用这些经验为新的诊断分类系统和未来的研究做出贡献。
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引用次数: 56
Development and validation of a Stress-related Vulnerability Scale 压力相关脆弱性量表的开发和验证
Pub Date : 2010-04-01 DOI: 10.1017/S1121189X00000889
L. Tarsitani, F. Battisti, M. Biondi, A. Picardi
In the last decades, an impressive body of literature has documented the noxious effects of emotional stress on mental and physical health (Lovallo, 2004). Also, evidence is accumulating that social relationships can have a positive impact on health (Cohen et al., 2000). Further, stress and support might interact, and an influential theoretical perspective hypothesizes that the belief that support is available reduces the noxious effects of stress on health. This is commonly referred to as the ‘stress buffering hypothesis’ and is supported by many studies (Lakey & Cohen, 2000). In stress research, there is an influential tradition which focuses on individuals' subjective evaluations of their abilities to cope with the demands posed by specific events or experiences, with an emphasis on perceived stressfulness of such events (Cohen et al., 1995). The literature on social support also suggests that the subjective perception of support has particular importance, as perceived support rather than objective support is associated with lower levels of autonomic activity, better immunosurveillance, and lower basal levels of stress hormones (Uchino et al., 1996). Several validated measures of perceived stress and perceived social support are available. However, there is a scarcity of instruments assessing both perceived stress and support that are short enough to be used in busy clinical routines. In this paper, we report about the development and validation of a short self-completed questionnaire, named Stress-related Vulnerability Scale (SVS), which enquires about both perceived stress and social support.
在过去的几十年里,大量令人印象深刻的文献记录了情绪压力对身心健康的有害影响(Lovallo, 2004)。此外,越来越多的证据表明,社会关系可以对健康产生积极影响(Cohen等人,2000年)。此外,压力和支持可能相互作用,一个有影响力的理论观点假设,相信支持是可用的,可以减少压力对健康的有害影响。这通常被称为“压力缓冲假说”,并得到许多研究的支持(Lakey & Cohen, 2000)。在压力研究中,有一个很有影响力的传统,它关注个人对自己应对特定事件或经历所带来的需求的能力的主观评估,强调对这些事件的感知压力(Cohen et al., 1995)。有关社会支持的文献也表明,对支持的主观感知特别重要,因为感知到的支持比客观支持与较低水平的自主神经活动、更好的免疫监视和较低的基础应激激素水平相关(Uchino et al., 1996)。一些有效的测量感知压力和感知社会支持是可用的。然而,在繁忙的临床程序中,评估感知到的压力和支持的工具很短,不足以使用。本文主要研究了压力相关脆弱性量表(stress -related Vulnerability Scale,简称SVS)的编制与验证,该量表主要考察心理压力感知与社会支持的关系。
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引用次数: 10
[Family members' assessment of community mental health services: a survey in four Italian regions]. [家庭成员对社区精神卫生服务的评估:意大利四个地区的调查]。
Pub Date : 2010-04-01
Alessia Bajoni, Angelo Barbato, Barbara D'Avanzo, Ernesto Muggia
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引用次数: 0
Diagnosis and treatment of depression in patients with advanced illness. 晚期抑郁症患者的诊断与治疗。
Pub Date : 2010-04-01
Susan D Block

This article reviews common sources of suffering in patients with advanced illness, identifies challenges in appropriately diagnosing and treating depression in this setting, and examines the relationship between depression and other key clinical outcomes in the setting of advanced disease. A systematic literature review was conducted. Most of the existing research on patients with advanced illness has been conducted with cancer patients. Approximately 18 percent of patients with advanced illness meet criteria for major or minor depression; multiple psychiatric co-morbidities occur frequently. Prevalence rates increase as patients become sicker. However, depression is frequently underdiagnosed and undertreated in the setting of advanced illness. One of the key clinical challenges is differentiating depression from grief. Both psychosocial and psychopharmacologic interventions have been shown to be effective in treating depression in patients with advanced cancer. In conclusion, depression is a regular complication of advanced illness, reduces quality of life, compromises family member function, interferes with treatment decisions, and may shorten survival. However, numerous effective treatment approaches, including both medications and psychotherapy, exist and can be used to alleviate depression.

本文回顾了晚期疾病患者常见的痛苦来源,确定了在这种情况下适当诊断和治疗抑郁症的挑战,并研究了晚期疾病情况下抑郁症与其他关键临床结果之间的关系。进行了系统的文献综述。现有的对晚期患者的研究大多是针对癌症患者进行的。大约18%的晚期患者符合重度或轻度抑郁症的标准;多种精神合并症经常发生。随着患者病情加重,患病率也会上升。然而,在晚期疾病的情况下,抑郁症经常被诊断和治疗不足。一个关键的临床挑战是区分抑郁和悲伤。社会心理和精神药物干预已被证明在治疗晚期癌症患者的抑郁症方面是有效的。总之,抑郁症是晚期疾病的常规并发症,降低生活质量,损害家庭成员的功能,干扰治疗决策,并可能缩短生存时间。然而,有许多有效的治疗方法,包括药物治疗和心理治疗,都可以用来缓解抑郁症。
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引用次数: 0
The potential role of the parietal lobe in schizophrenia 顶叶在精神分裂症中的潜在作用
Pub Date : 2010-04-01 DOI: 10.1017/S1121189X00000816
M. Bellani, A. Ferro, P. Brambilla
Abstract Although the anatomy of the parietal lobe has been under-investigated in schizophrenia, some magnetic resonance imaging studies have shown decreased volumes, suggesting its possible implication for the pathophysiology of the disease.
虽然对精神分裂症患者的顶叶解剖研究不足,但一些磁共振成像研究显示其体积减少,这表明其可能与疾病的病理生理有关。
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引用次数: 16
Delinquency in context; neighbourhood and gender interactions among adolescents. 犯罪语境;青少年之间的邻里和性别互动。
Pub Date : 2010-04-01
Marjan Drukker, Charles D Kaplan, Frans J M Feron, Jim Van Os, Andries Korebrits

Aim: Delinquency among adolescents and antecedent conduct disorder among children has been recognized as a growing public mental health problem in contemporary societies. The contribution of the neighbourhood environment to delinquent behaviour was examined in a cohort of Dutch adolescents (aged approximately 11 years at baseline; n = 394).

Methods: Multilevel regression analyses estimated associations between baseline neighbourhood socioeconomic status and social capital, and delinquent behaviour two years later controlling for individual-level variables.

Results: A significant interaction effect was found between neighbourhood environment variables and gender in models of delinquency, indicating that associations between neighbourhood environment variables and delinquency were apparent, for the most part, in girls only. However, higher level of neighbourhood informal social control was associated with increased delinquency rates in boys.

Conclusion: In girls there is a longitudinal association between neighbourhood characteristics and delinquency, suggesting complex gender differences in the way the wider social environment impacts on behavioural outcomes.

目的:青少年犯罪和儿童先前行为障碍已被认为是当代社会日益严重的公共心理健康问题。社区环境对犯罪行为的影响在一组荷兰青少年中进行了研究(基线年龄约为11岁;N = 394)。方法:多水平回归分析估计基线社区社会经济地位和社会资本之间的关系,以及两年后控制个人水平变量的犯罪行为。结果:在青少年犯罪模型中,邻里环境变量与性别之间存在显著的交互作用,表明邻里环境变量与青少年犯罪之间存在明显的关联,且大部分仅在女孩中存在。然而,较高的邻里非正式社会控制水平与男孩犯罪率上升有关。结论:在女孩中,邻里特征和犯罪之间存在纵向关联,这表明在更广泛的社会环境对行为结果的影响方式上存在复杂的性别差异。
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引用次数: 0
The need for closure in caregivers of people with psychosis. 精神病患者照护者的封闭需求。
Pub Date : 2010-04-01
Juliana Onwumere, Elizabeth Kuipers, Paul Bebbington, Graham Dunn, Daniel Freeman, David Fowler, Philippa Garety

Aim: The aim of the study was to determine how carer need for closure relates to expressed emotion. It also examined the links between carer need for closure and patient functioning including patient need for closure.

Methods: In a cross-sectional study, 70 caregivers of patients with psychosis completed the Need for Closure Scale (NFCS), the Camberwell Family Interview (CFI) and measures of distress, burden, coping and social network. The NFCS was assessed in terms of its two primary dimensions: a need for simple structure (NFSS) and Decisiveness. Patients also completed measures of psychotic symptoms and affect, and in 50 matched caregiver patient dyads, direct comparisons were undertaken between caregiver and patient NFCS scores.

Results: No links were found between caregiver NFC and EE in this predominately low EE sample. More decisive carers had higher levels of self esteem, were less distressed, and resorted less to avoidant coping. The need for simple structure was greater in carers who lacked a confidante. As predicted, patients reported significantly higher NFSS and lower Decisiveness scores than carers, but no relationship was observed between caregiver NFC and patient symptoms of psychosis.

Conclusions: Carers reporting confident decision making were also more likely to report adaptive functioning in terms of having lower levels of avoidant coping and distress, and higher levels of self esteem. The results suggest that this style of thinking might be a helpful way of coping with some of the difficulties involved in caring for someone with psychosis. D

目的:本研究的目的是确定照顾者对封闭的需求与表达的情绪之间的关系。它还检查了护理人员对关闭的需求与患者功能之间的联系,包括患者对关闭的需求。方法:采用横断面研究方法,对70名精神病患者的护理人员进行封闭需要量表(NFCS)、Camberwell家庭访谈(CFI)和困扰、负担、应对和社会网络测量。NFCS主要从两个方面进行评估:简单结构需求(NFSS)和决断性。患者还完成了精神病症状和影响的测量,在50对匹配的护理者和患者中,对护理者和患者的NFCS评分进行了直接比较。结果:在这个主要是低情感表达的样本中,没有发现护理人员NFC和情感表达之间的联系。更果断的照顾者有更高的自尊水平,更少痛苦,更少采取逃避应对。缺少知己的看护人对简单结构的需求更大。正如预测的那样,患者报告的NFSS明显高于护理人员,果断得分明显低于护理人员,但没有观察到护理人员NFC与患者精神病症状之间的关系。结论:报告自信决策的护理人员也更有可能报告适应功能,即回避性应对和痛苦水平较低,自尊水平较高。研究结果表明,这种思维方式可能是应对照顾精神病患者所涉及的一些困难的一种有益的方式。D
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引用次数: 0
The need for closure in caregivers of people with psychosis 精神病患者照护者的封闭需求
Pub Date : 2010-04-01 DOI: 10.1017/S1121189X00000865
J. Onwumere, E. Kuipers, P. Bebbington, G. Dunn, D. Freeman, D. Fowler, P. Garety
Summary Aim – The aim of the study was to determine how carer need for closure relates to expressed emotion. It also examined the links between carer need for closure and patient functioning including patient need for closure. Methods – In a cross-sectional study, 70 caregivers of patients with psychosis completed the Need for Closure Scale (NFCS), the Camberwell Family Interview (CFI) and measures of distress, burden, coping and social network. The NFCS was assessed in terms of its two primary dimensions: a need for simple structure (NFSS) and Decisiveness. Patients also completed measures of psychotic symptoms and affect, and in 50 matched caregiver patient dyads, direct comparisons were undertaken between caregiver and patient NFCS scores. Results – No links were found between caregiver NFC and EE in this predominately low EE sample. More decisive carers had higher levels of self esteem, were less distressed, and resorted less to avoidant coping. The need for simple structure was greater in carers who lacked a confidante. As predicted, patients reported significantly higher NFSS and lower Decisiveness scores than carers, but no relationship was observed between caregiver NFC and patient symptoms of psychosis. Conclusions – Carers reporting confident decision making were also more likely to report adaptive functioning in terms of having lower levels of avoidant coping and distress, and higher levels of self esteem. The results suggest that this style of thinking might be a helpful way of coping with some of the difficulties involved in caring for someone with psychosis.
目的总结:本研究的目的是确定照顾者对封闭的需求与表达的情绪之间的关系。它还检查了护理人员对关闭的需求与患者功能之间的联系,包括患者对关闭的需求。方法:在一项横断面研究中,70名精神病患者的护理人员完成了关闭需求量表(NFCS), Camberwell家庭访谈(CFI)和痛苦,负担,应对和社会网络的测量。NFCS主要从两个方面进行评估:简单结构需求(NFSS)和决断性。患者还完成了精神病症状和影响的测量,在50对匹配的护理者和患者中,对护理者和患者的NFCS评分进行了直接比较。结果-在这个主要是低情感表达的样本中,没有发现护理人员NFC和情感表达之间的联系。更果断的照顾者有更高的自尊水平,更少痛苦,更少采取逃避应对。缺少知己的看护人对简单结构的需求更大。正如预测的那样,患者报告的NFSS明显高于护理人员,果断得分明显低于护理人员,但没有观察到护理人员NFC与患者精神病症状之间的关系。结论——报告自信决策的护理人员也更有可能报告适应功能,即回避性应对和痛苦水平较低,自尊水平较高。研究结果表明,这种思维方式可能是应对照顾精神病患者所涉及的一些困难的一种有益的方式。
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引用次数: 7
Development and validation of a Stress-related Vulnerability Scale. 压力相关脆弱性量表的开发和验证。
Pub Date : 2010-04-01
Lorenzo Tarsitani, Francesca Battisti, Massimo Biondi, Angelo Picardi
{"title":"Development and validation of a Stress-related Vulnerability Scale.","authors":"Lorenzo Tarsitani,&nbsp;Francesca Battisti,&nbsp;Massimo Biondi,&nbsp;Angelo Picardi","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":72946,"journal":{"name":"Epidemiologia e psichiatria sociale","volume":"19 2","pages":"178-82"},"PeriodicalIF":0.0,"publicationDate":"2010-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29284567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Epidemiologia e psichiatria sociale
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