首页 > 最新文献

Global pediatrics最新文献

英文 中文
Beyond conjoined: A tale of successful separation of pyopagus twins 超越连体:侏儒双胞胎成功分离的故事
Pub Date : 2024-08-14 DOI: 10.1016/j.gpeds.2024.100226
Mudassar Fiaz Gondal, Noor Ul Sabah Butt, Usama Iftkhar, Hamna Atique, Jawad Abbasi, Muhammad Omer Fraz, Hafsa Atique, Saad Ahmed

Conjoined twins, a rare anomaly in which same-sex fetuses are partially or completely joined, present unique challenges in diagnosis and management. This article reports the first successful operative separation of pyopagus conjoint twins in Pakistan, an achievement in a low-resource setting. The female twins, diagnosed prenatally, underwent a planned cesarean section at 37 weeks. The initial physical examination revealed an 18 cm conjoined area with a shared anal opening. Postnatal monitoring in the neonatal intensive care unit detected abdominal distension, leading to pelvicdivided colostomies. A multidisciplinary team, including gynaecologists, anesthesiologists, pediatric medicine specialists, neurosurgeons, and pediatric surgeons, collaborated on the operative procedure of the six-month-olds. The process involved bone removal, dural incision, and anorectoplasty. Postoperatively, one twin experienced cerebrospinal fluid leakage, which was managed conservatively. The twins were discharged after a week with a one-month follow-up.

连体婴儿是一种罕见的异常情况,同性胎儿部分或完全连在一起,给诊断和管理带来了独特的挑战。本文报道了巴基斯坦首例成功分离脓疱疮连体双胞胎的手术,这是在资源匮乏的环境中取得的一项成就。这对女性双胞胎在产前即被确诊,并于 37 周时接受了计划中的剖宫产手术。初步体格检查显示,连体部位长 18 厘米,共用一个肛门口。新生儿重症监护室的产后监测发现腹部膨胀,导致骨盆分隔结肠造口。包括妇科医生、麻醉师、儿科内科专家、神经外科医生和儿科外科医生在内的多学科团队通力合作,为这对六个月大的婴儿实施了手术。手术过程包括骨切除、硬脑膜切开和肛门成形术。术后,一对双胞胎出现脑脊液漏,但得到了保守治疗。双胞胎一周后出院,随访一个月。
{"title":"Beyond conjoined: A tale of successful separation of pyopagus twins","authors":"Mudassar Fiaz Gondal,&nbsp;Noor Ul Sabah Butt,&nbsp;Usama Iftkhar,&nbsp;Hamna Atique,&nbsp;Jawad Abbasi,&nbsp;Muhammad Omer Fraz,&nbsp;Hafsa Atique,&nbsp;Saad Ahmed","doi":"10.1016/j.gpeds.2024.100226","DOIUrl":"10.1016/j.gpeds.2024.100226","url":null,"abstract":"<div><p>Conjoined twins, a rare anomaly in which same-sex fetuses are partially or completely joined, present unique challenges in diagnosis and management. This article reports the first successful operative separation of pyopagus conjoint twins in Pakistan, an achievement in a low-resource setting. The female twins, diagnosed prenatally, underwent a planned cesarean section at 37 weeks. The initial physical examination revealed an 18 cm conjoined area with a shared anal opening. Postnatal monitoring in the neonatal intensive care unit detected abdominal distension, leading to pelvicdivided colostomies. A multidisciplinary team, including gynaecologists, anesthesiologists, pediatric medicine specialists, neurosurgeons, and pediatric surgeons, collaborated on the operative procedure of the six-month-olds. The process involved bone removal, dural incision, and anorectoplasty. Postoperatively, one twin experienced cerebrospinal fluid leakage, which was managed conservatively. The twins were discharged after a week with a one-month follow-up.</p></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"9 ","pages":"Article 100226"},"PeriodicalIF":0.0,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667009724000940/pdfft?md5=5f26999914e73a3c5bfae8aaf00b9e33&pid=1-s2.0-S2667009724000940-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142021145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The utility of the child development review in Suriname: Validating a neurodevelopmental screener for use in a low- to middle- income Country 苏里南儿童发展审查的效用:验证在中低收入国家使用的神经发育筛选器
Pub Date : 2024-07-31 DOI: 10.1016/j.gpeds.2024.100225
Maria Kinsey , Arti Shankar , Waylon J. Hastings , Maureen Lichtveld , Noelle Martin , Brooke Maglia Batista , Anisma Gokoel , Shellice Sairras , Lauren W.Y. McLester-Davis , Stacy Drury , Wilco Zijlmans

Background

Access to efficient, culturally relevant, and validated measures of neurodevelopment in Low- and Middle-Income Countries (LMICs) remains a critical need. This study describes the validation and reliability of the Child Development Review (CDR), a parent report neurodevelopmental screening tool, for use in a cohort of Surinamese children aged 2–4 years.

Subjects

Complete data from 355 Surinamese children through the Caribbean Consortium for Research in Environmental and Occupational Health were utilized for validation. Convergent validity was assessed using a subset of 31 children with concurrently administered CDRs and Bayley Scales of Infant and Child Development Third Edition (BSID-III).

Methods

Cronbach's alpha was used to assess subscale reliability. Cluster analyses were used to assess internal factor structure. Measures of convergent validity used Cohen's Kappa statistic and partial correlations between comparative CDR and BSID-III subscales.

Results

Cronbach's Alpha values were acceptable for all CDR subscales (range 0.63 - 0.79). CDR subscale responses clustered into two distinct groups, representing milestones that were or were not achieved. Patterns of change indicate increased milestone achievement with increased age. Partial correlations indicated that the social, fine motor, and language subscales of the CDR and BSID-III subscales were significantly correlated. However, Cohen's Kappa was only significant for the gross motor CDR and BSID-III subscales.

Conclusions

The CDR has acceptable reliability, internal validity, and convergent validity. Use of the CDR should be considered as a screening tool for neurodevelopment in Suriname and may provide an efficient initial assessment of developmental delay in LMIC.

背景在中低收入国家(LMICs),获得高效、文化相关且经过验证的神经发育测量方法仍是一项关键需求。本研究介绍了儿童发育回顾(CDR)这一家长报告神经发育筛查工具在苏里南 2-4 岁儿童队列中的验证和可靠性。方法采用克隆巴赫α来评估子量表的可靠性。聚类分析用于评估内部因素结构。结果所有 CDR 分量表的 Alpha 值均可接受(范围为 0.63 - 0.79)。CDR 分量表的反应分为两个不同的组别,分别代表已实现或未实现的里程碑。变化模式表明,随着年龄的增长,里程碑的实现程度也在增加。部分相关性表明,CDR 的社交、精细动作和语言分量表与 BSID-III 分量表有显著相关性。结论 CDR 具有可接受的信度、内部效度和收敛效度。苏里南应将 CDR 作为神经发育筛查工具,并可为低收入国家提供有效的发育迟缓初步评估。
{"title":"The utility of the child development review in Suriname: Validating a neurodevelopmental screener for use in a low- to middle- income Country","authors":"Maria Kinsey ,&nbsp;Arti Shankar ,&nbsp;Waylon J. Hastings ,&nbsp;Maureen Lichtveld ,&nbsp;Noelle Martin ,&nbsp;Brooke Maglia Batista ,&nbsp;Anisma Gokoel ,&nbsp;Shellice Sairras ,&nbsp;Lauren W.Y. McLester-Davis ,&nbsp;Stacy Drury ,&nbsp;Wilco Zijlmans","doi":"10.1016/j.gpeds.2024.100225","DOIUrl":"10.1016/j.gpeds.2024.100225","url":null,"abstract":"<div><h3>Background</h3><p>Access to efficient, culturally relevant, and validated measures of neurodevelopment in Low- and Middle-Income Countries (LMICs) remains a critical need. This study describes the validation and reliability of the Child Development Review (CDR), a parent report neurodevelopmental screening tool, for use in a cohort of Surinamese children aged 2–4 years.</p></div><div><h3>Subjects</h3><p>Complete data from 355 Surinamese children through the Caribbean Consortium for Research in Environmental and Occupational Health were utilized for validation. Convergent validity was assessed using a subset of 31 children with concurrently administered CDRs and Bayley Scales of Infant and Child Development Third Edition (BSID-III).</p></div><div><h3>Methods</h3><p>Cronbach's alpha was used to assess subscale reliability. Cluster analyses were used to assess internal factor structure. Measures of convergent validity used Cohen's Kappa statistic and partial correlations between comparative CDR and BSID-III subscales.</p></div><div><h3>Results</h3><p>Cronbach's Alpha values were acceptable for all CDR subscales (range 0.63 - 0.79). CDR subscale responses clustered into two distinct groups, representing milestones that were or were not achieved. Patterns of change indicate increased milestone achievement with increased age. Partial correlations indicated that the social, fine motor, and language subscales of the CDR and BSID-III subscales were significantly correlated. However, Cohen's Kappa was only significant for the gross motor CDR and BSID-III subscales.</p></div><div><h3>Conclusions</h3><p>The CDR has acceptable reliability, internal validity, and convergent validity. Use of the CDR should be considered as a screening tool for neurodevelopment in Suriname and may provide an efficient initial assessment of developmental delay in LMIC.</p></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"9 ","pages":"Article 100225"},"PeriodicalIF":0.0,"publicationDate":"2024-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667009724000939/pdfft?md5=2c5c80dbb738066eb7b2644f6c49417b&pid=1-s2.0-S2667009724000939-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141953844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neuroprotective treatment options for neonatal hypoxic-ischemic encephalopathy: Therapeutic hypothermia and beyond 新生儿缺氧缺血性脑病的神经保护治疗方案:治疗性低温及其他
Pub Date : 2024-07-26 DOI: 10.1016/j.gpeds.2024.100223
Merih Cetinkaya

Hypoxic-ischemic encephalopathy (HIE) is the most common form of neonatal encephalopathy that develops due to perinatal asphyxia or ischemia in term and late-preterm infants. It is an important cause of significant neurological impairment and also mortality in newborns worldwide. The pathophysiology of HIE is multifactorial and involves complex cascades of cellular and biochemical events in the brain including excitotoxicity, oxidative stress, inflammation, and cell death, respectively. Therapeutic hypothermia (TH), is the only standard neuroprotective therapy for HIE and is associated with reduced composite outcome of death or major neurodevelopmental disability. However, although TH is beneficial, neonates with HIE still experience unacceptably high rate of devistating morbidities. Therefore, research for adjunctive therapies continue to further improve outcomes in infants with HIE. In this review, both TH and other promising adjunctive neuroprotective therapies are discussed for developing future treatment strategies.

缺氧缺血性脑病(HIE)是足月儿和晚早产儿因围产期窒息或缺血而发生的最常见的新生儿脑病。它是导致全球新生儿严重神经功能损伤和死亡的重要原因。HIE 的病理生理学是多因素的,涉及大脑中复杂的细胞和生化事件级联,分别包括兴奋毒性、氧化应激、炎症和细胞死亡。治疗性低温(TH)是治疗 HIE 的唯一标准神经保护疗法,可减少死亡或严重神经发育障碍的综合结果。然而,尽管治疗性低温疗法有益,但患有 HIE 的新生儿仍会出现令人无法接受的高死亡率。因此,对辅助疗法的研究仍在继续,以进一步改善 HIE 婴儿的预后。在这篇综述中,我们将讨论 TH 和其他有前景的辅助神经保护疗法,以制定未来的治疗策略。
{"title":"Neuroprotective treatment options for neonatal hypoxic-ischemic encephalopathy: Therapeutic hypothermia and beyond","authors":"Merih Cetinkaya","doi":"10.1016/j.gpeds.2024.100223","DOIUrl":"10.1016/j.gpeds.2024.100223","url":null,"abstract":"<div><p>Hypoxic-ischemic encephalopathy (HIE) is the most common form of neonatal encephalopathy that develops due to perinatal asphyxia or ischemia in term and late-preterm infants. It is an important cause of significant neurological impairment and also mortality in newborns worldwide. The pathophysiology of HIE is multifactorial and involves complex cascades of cellular and biochemical events in the brain including excitotoxicity, oxidative stress, inflammation, and cell death, respectively. Therapeutic hypothermia (TH), is the only standard neuroprotective therapy for HIE and is associated with reduced composite outcome of death or major neurodevelopmental disability. However, although TH is beneficial, neonates with HIE still experience unacceptably high rate of devistating morbidities. Therefore, research for adjunctive therapies continue to further improve outcomes in infants with HIE. In this review, both TH and other promising adjunctive neuroprotective therapies are discussed for developing future treatment strategies.</p></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"9 ","pages":"Article 100223"},"PeriodicalIF":0.0,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667009724000915/pdfft?md5=cdf0a71b1ff18024db042aa41d5e0a9e&pid=1-s2.0-S2667009724000915-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141839228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rationale for use for monoclonal antibody and anti-cytokine therapy for multisystem inflammatory syndrome in children: A systematic review 儿童多系统炎症综合征单克隆抗体和抗细胞因子疗法的使用理由:系统性综述
Pub Date : 2024-07-23 DOI: 10.1016/j.gpeds.2024.100222
Jason Louis Reyes , Sandra Salter , Frank Sanfilippo , Pamela Bradshaw , Bradley MacDonald

Objective

To review systematically the rationale for choice and use of monoclonal antibody and anti-cytokine therapy in multisystem inflammatory syndrome in children.

Study design

A systematic review was conducted using electronic databases (MEDLINE, Embase, Global Health, SCOPUS, and Web of Science) and preprint servers (MedRxiv and BioRxiv) between 01/01/2020 and 01/03/22. Studies were included if they had pediatric patients aged <21 years with multisystem inflammatory syndrome that had experienced the use of monoclonal antibodies and anti-cytokine therapy. Randomized controlled trials, cohort studies, case reports, case series and case-control studies were included.

Results

Twenty observational studies with 726 patients were included. Anakinra, tocilizumab and infliximab were used in 9.9%, 6.9%, and 12.4% of the cases, respectively. The most common rationale for the initiation of emerging therapy for multisystem inflammatory syndrome in children was for patients who presented with severe disease or refractory to first line therapy. Infliximab tended to be used because of its precedence in managing intravenous immunoglobulin-resistant Kawasaki Disease.

Conclusions

Use and choice of monoclonal antibody and anti-cytokine therapy seems to rely more on subjective clinician preferences than rigorous evidence-based studies. More studies exploring the exact pathogenesis of multisystem inflammatory syndrome in children are warranted to identify the key players of the cytokine storm that act as biological targets and their outcomes.

研究设计在2020年1月1日至3月22日期间,利用电子数据库(MEDLINE、Embase、Global Health、SCOPUS和Web of Science)和预印本服务器(MedRxiv和BioRxiv)进行了系统性综述。研究对象包括年龄在 21 岁以下、曾使用过单克隆抗体和抗细胞因子疗法的多系统炎症综合征儿科患者。纳入的研究包括随机对照试验、队列研究、病例报告、病例系列和病例对照研究。分别有9.9%、6.9%和12.4%的病例使用了阿纳金拉、妥西珠单抗和英夫利西单抗。启动儿童多系统炎症综合征新疗法的最常见原因是患者病情严重或对一线疗法难治。结论 单克隆抗体和抗细胞因子疗法的使用和选择似乎更多地依赖于临床医生的主观偏好,而非严谨的循证研究。有必要开展更多研究,探索儿童多系统炎症综合征的确切发病机制,以确定作为生物靶点的细胞因子风暴的关键参与者及其结果。
{"title":"Rationale for use for monoclonal antibody and anti-cytokine therapy for multisystem inflammatory syndrome in children: A systematic review","authors":"Jason Louis Reyes ,&nbsp;Sandra Salter ,&nbsp;Frank Sanfilippo ,&nbsp;Pamela Bradshaw ,&nbsp;Bradley MacDonald","doi":"10.1016/j.gpeds.2024.100222","DOIUrl":"10.1016/j.gpeds.2024.100222","url":null,"abstract":"<div><h3>Objective</h3><p>To review systematically the rationale for choice and use of monoclonal antibody and anti-cytokine therapy in multisystem inflammatory syndrome in children.</p></div><div><h3>Study design</h3><p>A systematic review was conducted using electronic databases (MEDLINE, Embase, Global Health, SCOPUS, and Web of Science) and preprint servers (MedRxiv and BioRxiv) between 01/01/2020 and 01/03/22. Studies were included if they had pediatric patients aged &lt;21 years with multisystem inflammatory syndrome that had experienced the use of monoclonal antibodies and anti-cytokine therapy. Randomized controlled trials, cohort studies, case reports, case series and case-control studies were included.</p></div><div><h3>Results</h3><p>Twenty observational studies with 726 patients were included. Anakinra, tocilizumab and infliximab were used in 9.9%, 6.9%, and 12.4% of the cases, respectively. The most common rationale for the initiation of emerging therapy for multisystem inflammatory syndrome in children was for patients who presented with severe disease or refractory to first line therapy. Infliximab tended to be used because of its precedence in managing intravenous immunoglobulin-resistant Kawasaki Disease.</p></div><div><h3>Conclusions</h3><p>Use and choice of monoclonal antibody and anti-cytokine therapy seems to rely more on subjective clinician preferences than rigorous evidence-based studies. More studies exploring the exact pathogenesis of multisystem inflammatory syndrome in children are warranted to identify the key players of the cytokine storm that act as biological targets and their outcomes.</p></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"9 ","pages":"Article 100222"},"PeriodicalIF":0.0,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667009724000903/pdfft?md5=1d966f2cb78be62108518988834865fd&pid=1-s2.0-S2667009724000903-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141848369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The evolving role of social media in paediatric dentistry: A narrative review 社交媒体在儿童牙科中不断演变的作用:叙述性评论
Pub Date : 2024-07-22 DOI: 10.1016/j.gpeds.2024.100221
Supriya Bhatara, Mousumi Goswami, Aditya Saxena, Prachi Pathak, Shivya Tuli, Bhawna Saxena

Background

With the advent of newer technologies and advances in internet and communication technologies, we must use the social media tools that have proved to be an integral asset in raising awareness, behaviour guidance and instilling positive dental attitudes and practices in children.

Aim

This review aims to discuss how the role of social media has evolved as an adjunctive tool in the field of paediatric dentistry.

Method

The review was outlined as per the Scale for the Assessment of Narrative Review Articles (SANRA). A systematic search of various databases was done using relevant MeSH terms and other keywords. Categorisation of the relevant studies was done under the following themes for a comprehensive understanding of the role of social media in paediatric dentistry; a) General Statistics, b) Health promotion, c) Improvement in treatment outcomes, d) Practice building, and e) Ethical and Regulatory Practices.

Results and conclusion

Evolving role of social media in paediatric dentistry has significantly transformed communication, patient management and education within the field. However, with the increasing influence of social media, there is a critical need for regulation.

背景随着互联网和通信技术的更新和进步,我们必须使用社交媒体工具,事实证明这些工具在提高儿童意识、行为指导和灌输积极的牙科态度和实践方面是不可或缺的资产。方法根据叙事性综述文章评估量表(SANRA)对综述进行概述。使用相关的 MeSH 术语和其他关键词对各种数据库进行了系统检索。为了全面了解社交媒体在儿童牙科中的作用,我们按照以下主题对相关研究进行了分类:a) 一般统计,b) 健康促进,c) 改善治疗效果,d) 实践建设,以及 e) 道德和监管实践。然而,随着社交媒体的影响力不断增加,亟需进行监管。
{"title":"The evolving role of social media in paediatric dentistry: A narrative review","authors":"Supriya Bhatara,&nbsp;Mousumi Goswami,&nbsp;Aditya Saxena,&nbsp;Prachi Pathak,&nbsp;Shivya Tuli,&nbsp;Bhawna Saxena","doi":"10.1016/j.gpeds.2024.100221","DOIUrl":"10.1016/j.gpeds.2024.100221","url":null,"abstract":"<div><h3>Background</h3><p>With the advent of newer technologies and advances in internet and communication technologies, we must use the social media tools that have proved to be an integral asset in raising awareness, behaviour guidance and instilling positive dental attitudes and practices in children.</p></div><div><h3>Aim</h3><p>This review aims to discuss how the role of social media has evolved as an adjunctive tool in the field of paediatric dentistry.</p></div><div><h3>Method</h3><p>The review was outlined as per the Scale for the Assessment of Narrative Review Articles (SANRA). A systematic search of various databases was done using relevant MeSH terms and other keywords. Categorisation of the relevant studies was done under the following themes for a comprehensive understanding of the role of social media in paediatric dentistry; a) General Statistics, b) Health promotion, c) Improvement in treatment outcomes, d) Practice building, and e) Ethical and Regulatory Practices.</p></div><div><h3>Results and conclusion</h3><p>Evolving role of social media in paediatric dentistry has significantly transformed communication, patient management and education within the field. However, with the increasing influence of social media, there is a critical need for regulation.</p></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"9 ","pages":"Article 100221"},"PeriodicalIF":0.0,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667009724000897/pdfft?md5=64c4dd4f52d02a34e6c0e4b0eb58569c&pid=1-s2.0-S2667009724000897-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141852371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Leveraging machine learning to study how temperament scores predict pre-term birth status 利用机器学习研究气质评分如何预测早产状况
Pub Date : 2024-07-22 DOI: 10.1016/j.gpeds.2024.100220
Erich Seamon , Jennifer.A. Mattera , Sarah.A. Keim , Esther.M. Leerkes , Jennifer.L. Rennels , Andrea.J. Kayl , Kirsty.M. Kulhanek , Darcia Narvaez , Sarah.M. Sanborn , Jennifer.B. Grandits , Christine Dunkel Schetter , Mary Coussons-Read , Amanda.R. Tarullo , Sarah.J. Schoppe-Sullivan , Moriah.E. Thomason , Julie.M. Braungart-Rieker , Julie.C. Lumeng , Shannon.N. Lenze , Lisa M. Christian , Darby.E. Saxbe , Maria.A. Gartstein

Background

Preterm birth (birth at <37 completed weeks gestation) is a significant public heatlh concern worldwide. Important health, and developmental consequences of preterm birth include altered temperament development, with greater dysregulation and distress proneness.

Aims

The present study leveraged advanced quantitative techniques, namely machine learning approaches, to discern the contribution of narrowly defined and broadband temperament dimensions to birth status classification (full-term vs. preterm). Along with contributing to the literature addressing temperament of infants born preterm, the present study serves as a methodological demonstration of these innovative statistical techniques.

Study design

This study represents a metanalysis conducted with multiple samples (N = 19) including preterm (n = 201) children and (n = 402) born at term, with data combined across investigations to perform classification analyses.

Subjects

Participants included infants born preterm and term-born comparison children, either matched on chronological age or age adjusted for prematurity.

Outcome measures

Infant Behavior Questionnaire-Revised Very Short Form (IBQ-R VSF) was completed by mothers, with factor and item-level data considered herein.

Results and conclusions

Accuracy estimates were generally similar regardless of the comparison groups. Results indicated a slightly higher accuracy and efficiency for IBQR-VSF item-based models vs. factor-level models. Divergent patterns of feature importance (i.e., the extent to which a factor/item contributed to classification) were observed for the two comparison groups (chronological age vs. adjusted age) using factor-level scores; however, itemized models indicated that the two most critical items were associated with effortful control and negative emotionality regardless of comparison group.

背景早产(妊娠满 37 周时出生)是全球关注的重大公共卫生问题。本研究利用先进的定量技术,即机器学习方法,来鉴别狭义和宽带气质维度对出生状态分类(足月与早产)的贡献。研究设计本研究是一项荟萃分析,使用了多个样本(N = 19),包括早产儿(n = 201)和足月儿(n = 402),将不同调查的数据结合起来进行分类分析。结果测量婴儿行为问卷-修订版极简表(IBQ-R VSF)由母亲填写,本文考虑了因子和项目级数据。结果和结论无论对比组如何,准确度估计值基本相似。结果表明,基于 IBQR-VSF 项目模型的准确度和效率略高于基于因子模型的准确度和效率。在使用因子水平得分的两个比较组(年代年龄与调整后年龄)中,观察到了特征重要性(即因子/项目对分类的贡献程度)的不同模式;然而,分项模型表明,无论比较组如何,两个最关键的项目都与努力控制和消极情绪有关。
{"title":"Leveraging machine learning to study how temperament scores predict pre-term birth status","authors":"Erich Seamon ,&nbsp;Jennifer.A. Mattera ,&nbsp;Sarah.A. Keim ,&nbsp;Esther.M. Leerkes ,&nbsp;Jennifer.L. Rennels ,&nbsp;Andrea.J. Kayl ,&nbsp;Kirsty.M. Kulhanek ,&nbsp;Darcia Narvaez ,&nbsp;Sarah.M. Sanborn ,&nbsp;Jennifer.B. Grandits ,&nbsp;Christine Dunkel Schetter ,&nbsp;Mary Coussons-Read ,&nbsp;Amanda.R. Tarullo ,&nbsp;Sarah.J. Schoppe-Sullivan ,&nbsp;Moriah.E. Thomason ,&nbsp;Julie.M. Braungart-Rieker ,&nbsp;Julie.C. Lumeng ,&nbsp;Shannon.N. Lenze ,&nbsp;Lisa M. Christian ,&nbsp;Darby.E. Saxbe ,&nbsp;Maria.A. Gartstein","doi":"10.1016/j.gpeds.2024.100220","DOIUrl":"10.1016/j.gpeds.2024.100220","url":null,"abstract":"<div><h3>Background</h3><p>Preterm birth (birth at &lt;37 completed weeks gestation) is a significant public heatlh concern worldwide. Important health, and developmental consequences of preterm birth include altered temperament development, with greater dysregulation and distress proneness.</p></div><div><h3>Aims</h3><p>The present study leveraged advanced quantitative techniques, namely machine learning approaches, to discern the contribution of narrowly defined and broadband temperament dimensions to birth status classification (full-term vs. preterm). Along with contributing to the literature addressing temperament of infants born preterm, the present study serves as a methodological demonstration of these innovative statistical techniques.</p></div><div><h3>Study design</h3><p>This study represents a metanalysis conducted with multiple samples (<em>N</em> = 19) including preterm (<em>n</em> = 201) children and (<em>n</em> = 402) born at term, with data combined across investigations to perform classification analyses.</p></div><div><h3>Subjects</h3><p>Participants included infants born preterm and term-born comparison children, either matched on chronological age or age adjusted for prematurity.</p></div><div><h3>Outcome measures</h3><p>Infant Behavior Questionnaire-Revised Very Short Form (IBQ-R VSF) was completed by mothers, with factor and item-level data considered herein.</p></div><div><h3>Results and conclusions</h3><p>Accuracy estimates were generally similar regardless of the comparison groups. Results indicated a slightly higher accuracy and efficiency for IBQR-VSF item-based models vs. factor-level models. Divergent patterns of feature importance (i.e., the extent to which a factor/item contributed to classification) were observed for the two comparison groups (chronological age vs. adjusted age) using factor-level scores; however, itemized models indicated that the two most critical items were associated with effortful control and negative emotionality regardless of comparison group.</p></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"9 ","pages":"Article 100220"},"PeriodicalIF":0.0,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667009724000885/pdfft?md5=1a2af592f73c14d491cf4291a9e9e8ef&pid=1-s2.0-S2667009724000885-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141849459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The past and the future of paediatric primary care 儿科初级保健的过去与未来
Pub Date : 2024-07-20 DOI: 10.1016/j.gpeds.2024.100218
Laura Reali , Arianna Turriziani Colonna , Shimon Barak

The significant advancement that medicine has achieved in the past century is the transition from a focus on "treating the sick" to a focus on "caring for health." The focus of pediatric primary care (PPC) is to care for the health and well-being of infants, children, and adolescents in their environment. It places emphasis on their autonomy and personal well-being while also involving parents, guardians, and caregivers. They provide this care within their family, community, and culture. Primary care pediatricians (PCPs) play a vital role in tackling global child health issues such as complex and chronic non-communicable diseases or refugee children. The primary focus of the ECPCP core curriculum for PCPs and the WHO's Pocketbook is to highlight the importance of enhancing primary healthcare, namely through the integration of comprehensive management for all pediatric disorders and conditions. PCPs should receive training on accessibility, closeness, continuity, and trust, as well as collaboration with related specialists. The ECPCP curriculum emphasizes fundamental subjects and abilities that are crucial for future PCPs.

医学在上个世纪取得的重大进步,就是从 "治疗疾病 "到 "关爱健康 "的转变。儿科初级保健(PPC)的重点是关注婴儿、儿童和青少年在其所处环境中的健康和福祉。它强调他们的自主性和个人福祉,同时也让父母、监护人和照顾者参与其中。他们在家庭、社区和文化中提供这种护理。初级保健儿科医生(PCPs)在解决复杂和慢性非传染性疾病或难民儿童等全球儿童健康问题方面发挥着至关重要的作用。针对初级保健儿科医生的 ECPCP 核心课程和世卫组织《袖珍手册》的主要重点是强调加强初级保健的重要性,即通过综合管理所有儿科疾病和病症。初级保健医生应接受关于可及性、亲近性、连续性和信任以及与相关专家合作的培训。ECPCP 课程强调对未来初级保健医生至关重要的基本科目和能力。
{"title":"The past and the future of paediatric primary care","authors":"Laura Reali ,&nbsp;Arianna Turriziani Colonna ,&nbsp;Shimon Barak","doi":"10.1016/j.gpeds.2024.100218","DOIUrl":"10.1016/j.gpeds.2024.100218","url":null,"abstract":"<div><p>The significant advancement that medicine has achieved in the past century is the transition from a focus on \"treating the sick\" to a focus on \"caring for health.\" The focus of pediatric primary care (PPC) is to care for the health and well-being of infants, children, and adolescents in their environment. It places emphasis on their autonomy and personal well-being while also involving parents, guardians, and caregivers. They provide this care within their family, community, and culture. Primary care pediatricians (PCPs) play a vital role in tackling global child health issues such as complex and chronic non-communicable diseases or refugee children. The primary focus of the ECPCP core curriculum for PCPs and the WHO's Pocketbook is to highlight the importance of enhancing primary healthcare, namely through the integration of comprehensive management for all pediatric disorders and conditions. PCPs should receive training on accessibility, closeness, continuity, and trust, as well as collaboration with related specialists. The ECPCP curriculum emphasizes fundamental subjects and abilities that are crucial for future PCPs.</p></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"9 ","pages":"Article 100218"},"PeriodicalIF":0.0,"publicationDate":"2024-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667009724000861/pdfft?md5=286f567a86c3238adfd7cbd71f2497df&pid=1-s2.0-S2667009724000861-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141844489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A tool to assess early motor skill development: A study of Danish health visitors’ practice 评估早期运动技能发展的工具:丹麦健康访视员实践研究
Pub Date : 2024-07-17 DOI: 10.1016/j.gpeds.2024.100219
Marlene Rosager Lund Pedersen , Silja Høyer Preisler , Julie Nicoline Østergaard Bang , Danae Dinkel , Lise Hestbæk

In Denmark, health visitors play a crucial role in identifying early motor skill difficulties. In 74 % of the Danish municipalities, they use a motor skill assessment tool for infants aged 9–11 months, consisting of evaluating nine motor milestones. The assessment results in one of three remarks: 'age-appropriate motor development', ‘heightened attention required', or 'intervention needed'. This article aims to: 1) determine the relative importance of each milestone in the overall assessment score, 2) investigate the consistencies in test usage across municipalities, and 3) explore factors influencing health visitors' assessments. This mixed methods study utilizes questionnaires and interviews with health visitors from two municipalities. Findings indicate a general consistency in the importance of each motor milestone in both municipalities, with the exception of the milestone 'chews food with a coarser consistency and takes an interest in eating by him/herself.' The health visitors also consider the achievement of the nine-motor milestones more important as the child gets older. Health visitors in both municipalities follow a uniform approach, emphasizing continuous child development over specific motor milestone achievement. They also consider factors like interaction, sensory perception, overall and social development, and the joy of movement, which are not part of the formal assessment. This illustrates that the health visitors have a dynamic system approach to testing motor development, broadening the motor assessment beyond the tool's milestones.

在丹麦,健康访视员在识别早期运动技能困难方面发挥着至关重要的作用。在丹麦 74% 的城市中,他们对 9-11 个月大的婴儿使用运动技能评估工具,包括评估九个运动里程碑。评估结果有三个备注:"与年龄相符的运动发展"、"需要加强关注 "或 "需要干预"。本文旨在1)确定每个里程碑在总体评估得分中的相对重要性;2)调查各市使用测试的一致性;3)探讨影响健康访视员评估的因素。这项混合方法研究采用了问卷调查和访谈的方式,访问了来自两个城市的健康访视者。研究结果表明,除了'咀嚼较粗糙的食物并对自己进食感兴趣'这一里程碑外,两个城市对每个运动里程碑的重要性的看法基本一致。健康访视员还认为,随着孩子年龄的增长,实现九个运动里程碑也变得更加重要。这两个城市的健康访视员都采用统一的方法,强调儿童的持续发展,而不是达到特定的运动里程碑。他们还会考虑互动、感官知觉、整体和社会发展以及运动的快乐等因素,而这些并不是正式评估的一部分。这说明健康访视员采用动态系统的方法来测试运动发展,将运动评估扩展到工具里程碑之外。
{"title":"A tool to assess early motor skill development: A study of Danish health visitors’ practice","authors":"Marlene Rosager Lund Pedersen ,&nbsp;Silja Høyer Preisler ,&nbsp;Julie Nicoline Østergaard Bang ,&nbsp;Danae Dinkel ,&nbsp;Lise Hestbæk","doi":"10.1016/j.gpeds.2024.100219","DOIUrl":"10.1016/j.gpeds.2024.100219","url":null,"abstract":"<div><p>In Denmark, health visitors play a crucial role in identifying early motor skill difficulties. In 74 % of the Danish municipalities, they use a motor skill assessment tool for infants aged 9–11 months, consisting of evaluating nine motor milestones. The assessment results in one of three remarks: 'age-appropriate motor development', ‘heightened attention required', or 'intervention needed'. This article aims to: 1) determine the relative importance of each milestone in the overall assessment score, 2) investigate the consistencies in test usage across municipalities, and 3) explore factors influencing health visitors' assessments. This mixed methods study utilizes questionnaires and interviews with health visitors from two municipalities. Findings indicate a general consistency in the importance of each motor milestone in both municipalities, with the exception of the milestone 'chews food with a coarser consistency and takes an interest in eating by him/herself.' The health visitors also consider the achievement of the nine-motor milestones more important as the child gets older. Health visitors in both municipalities follow a uniform approach, emphasizing continuous child development over specific motor milestone achievement. They also consider factors like interaction, sensory perception, overall and social development, and the joy of movement, which are not part of the formal assessment. This illustrates that the health visitors have a dynamic system approach to testing motor development, broadening the motor assessment beyond the tool's milestones.</p></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"9 ","pages":"Article 100219"},"PeriodicalIF":0.0,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667009724000873/pdfft?md5=9cf8cade5f7d13c9d4aa07e73e858ca1&pid=1-s2.0-S2667009724000873-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141848250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Osteogenesis imperfecta type II with patent ductus arteriosus, severe persistent pulmonary hypertension, sepsis and severe thrombocytopenia in a neonate: A case report 新生儿 II 型成骨不全伴动脉导管未闭、严重持续性肺动脉高压、败血症和严重血小板减少症:病例报告
Pub Date : 2024-07-05 DOI: 10.1016/j.gpeds.2024.100203
Mansoor Aslamzai , Mohammad Sharif Sediqi , Mohmand Mangal , Ataullah Shinwarie

Background

Osteogenesis imperfecta type II is a rare congenital anomaly that usually causes death in utero or shortly after birth.

Case Presentation

This study reports a rare case of osteogenesis imperfecta type II in an Afghan girl who was one day old. The defect was accompanied by a patent ductus arteriosus, severe persistent pulmonary hypertension of the newborn, sepsis, severe thrombocytopenia, and low birth weight during the first four days of life. These disorders were diagnosed by medical history, physical examination, blood investigation, computed tomography, x-ray, and doppler ultrasonography. On the fifth day of life, the newborn suffered an abrupt cardio-pulmonary arrest that resulted in her death, presumably due to brainstem compression or severe persistent pulmonary hypertension of the newborn.

Conclusion

Osteogenesis imperfecta type II can result in life-threatening complications during the first week of life.

背景II型成骨不全症是一种罕见的先天性畸形,通常会导致婴儿在子宫内或出生后不久死亡。 本研究报告了一例罕见的II型成骨不全症病例,患儿是一名出生仅一天的阿富汗女童。该缺陷伴有动脉导管未闭、新生儿严重的持续性肺动脉高压、败血症、严重血小板减少症,以及出生后头四天体重过轻。这些疾病都是通过病史、体格检查、血液检查、计算机断层扫描、X 光检查和多普勒超声波检查确诊的。新生儿在出生后第五天突然心肺功能骤停导致死亡,可能是由于脑干受压或新生儿严重的持续性肺动脉高压所致。
{"title":"Osteogenesis imperfecta type II with patent ductus arteriosus, severe persistent pulmonary hypertension, sepsis and severe thrombocytopenia in a neonate: A case report","authors":"Mansoor Aslamzai ,&nbsp;Mohammad Sharif Sediqi ,&nbsp;Mohmand Mangal ,&nbsp;Ataullah Shinwarie","doi":"10.1016/j.gpeds.2024.100203","DOIUrl":"https://doi.org/10.1016/j.gpeds.2024.100203","url":null,"abstract":"<div><h3>Background</h3><p>Osteogenesis imperfecta type II is a rare congenital anomaly that usually causes death in utero or shortly after birth.</p></div><div><h3>Case Presentation</h3><p>This study reports a rare case of osteogenesis imperfecta type II in an Afghan girl who was one day old. The defect was accompanied by a patent ductus arteriosus, severe persistent pulmonary hypertension of the newborn, sepsis, severe thrombocytopenia, and low birth weight during the first four days of life. These disorders were diagnosed by medical history, physical examination, blood investigation, computed tomography, x-ray, and doppler ultrasonography. On the fifth day of life, the newborn suffered an abrupt cardio-pulmonary arrest that resulted in her death, presumably due to brainstem compression or severe persistent pulmonary hypertension of the newborn.</p></div><div><h3>Conclusion</h3><p>Osteogenesis imperfecta type II can result in life-threatening complications during the first week of life.</p></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"9 ","pages":"Article 100203"},"PeriodicalIF":0.0,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S266700972400071X/pdfft?md5=8440e903f407a366a14cb6ed93fb7f65&pid=1-s2.0-S266700972400071X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141605243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Microbiota and gut immunity in infants and young children 婴幼儿的微生物群和肠道免疫力
Pub Date : 2024-07-04 DOI: 10.1016/j.gpeds.2024.100202
Giuseppe Buonocore

The human gut microbiome plays a critical role in maintaining human health, particularly in the intricate relationship between stable microbial communities in the gastrointestinal tract and the early development of host immunity. After birth, the maturation of immune cells and the gut microbiome occur simultaneously, adapting to the complexities of the gut environment. The close link between the gut microbiome and the immune system has far-reaching implications, influencing the onset of several diseases in infants and young children, such as food allergies, necrotizing colitis, obesity, and inflammatory bowel disease. Consequently, the composition of the infant gut microbiome serves as a predictive factor for disease risk and progression. The establishment of a symbiosis between the immune system and the gut microbiome has significant implications for susceptibility or resistance to disease later in life. Maternal factors, including mode of delivery and feeding practices, exert a significant influence on the infant gut microbiota.

人类肠道微生物组在维持人类健康方面发挥着至关重要的作用,特别是在胃肠道稳定的微生物群落与宿主免疫力的早期发展之间存在着错综复杂的关系。出生后,免疫细胞和肠道微生物群同时成熟,以适应复杂的肠道环境。肠道微生物群与免疫系统之间的密切联系具有深远的影响,会影响婴幼儿多种疾病的发病,如食物过敏、坏死性结肠炎、肥胖和炎症性肠病。因此,婴儿肠道微生物组的组成是疾病风险和进展的预测因素。免疫系统与肠道微生物组之间共生关系的建立对日后易感性或抗病能力有重要影响。母体因素,包括分娩方式和喂养方式,对婴儿肠道微生物群有重大影响。
{"title":"Microbiota and gut immunity in infants and young children","authors":"Giuseppe Buonocore","doi":"10.1016/j.gpeds.2024.100202","DOIUrl":"https://doi.org/10.1016/j.gpeds.2024.100202","url":null,"abstract":"<div><p>The human gut microbiome plays a critical role in maintaining human health, particularly in the intricate relationship between stable microbial communities in the gastrointestinal tract and the early development of host immunity. After birth, the maturation of immune cells and the gut microbiome occur simultaneously, adapting to the complexities of the gut environment. The close link between the gut microbiome and the immune system has far-reaching implications, influencing the onset of several diseases in infants and young children, such as food allergies, necrotizing colitis, obesity, and inflammatory bowel disease. Consequently, the composition of the infant gut microbiome serves as a predictive factor for disease risk and progression. The establishment of a symbiosis between the immune system and the gut microbiome has significant implications for susceptibility or resistance to disease later in life. Maternal factors, including mode of delivery and feeding practices, exert a significant influence on the infant gut microbiota.</p></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"9 ","pages":"Article 100202"},"PeriodicalIF":0.0,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667009724000708/pdfft?md5=2680013c3afe54bda6cb331360134410&pid=1-s2.0-S2667009724000708-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141605215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Global pediatrics
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1