Pub Date : 2025-09-04DOI: 10.1016/j.gpeds.2025.100292
Serafina Perrone , Laura Cannavò , Virginia Beretta , Elena Scarpa , Serena Benedetti , Chiara Petrolini , Vincenzo Raitano , Domenico Corica , Tommaso Aversa , Maria Cristina Albertini , Andrea Dall’Asta , Maria Elisabeth Street , Tullio Ghi , Silvia Carloni , Malgorzata Wasniewska
Bone health during childhood is critical for proper skeletal development and long-term quality of life. The process of bone formation relies on a balance of mineralization and cellular activity, which is regulated by oxidative stress (OS). While physiological levels of reactive oxygen species (ROS) are important for normal bone cell function and homeostasis, excessive OS can contribute to the development of bone diseases, such as osteoarthritis and osteoporosis. Enzymes like xanthine oxidoreductase are involved in amplifying ROS production, which can lead to cartilage degradation and disrupted bone remodeling. Despite increasing recognition of OS as a risk factor in adult skeletal health, its impact on fetal and neonatal bone development remains underexplored. In vitro and animal model studies, including those using free radicals exposure, have been performed to understand how OS impairs osteogenesis.
This review examines the role of OS in perinatal bone development analyzing key environmental risk factors and the potential long-term consequences of early-life redox imbalance on skeletal health.
The sensitivity of the fetal bone to OS suggests that oxidative damage during this critical period can result in impaired bone growth, low birth weight, and long-term skeletal disorders. Oxidative stress interferes with osteoblast differentiation, enhances adipocyte formation from mesenchymal stem cells, and stimulates osteoclast activity, leading to bone resorption. Clinical studies on the impact of OS on neonatal bone metabolism remain limited. Identifying key risk factors for early-life redox imbalance could be crucial in developing potential antioxidant therapies to support skeletal health during childhood
{"title":"Early bone health: exploring relationship between oxidative stress and skeletal development in newborn infants","authors":"Serafina Perrone , Laura Cannavò , Virginia Beretta , Elena Scarpa , Serena Benedetti , Chiara Petrolini , Vincenzo Raitano , Domenico Corica , Tommaso Aversa , Maria Cristina Albertini , Andrea Dall’Asta , Maria Elisabeth Street , Tullio Ghi , Silvia Carloni , Malgorzata Wasniewska","doi":"10.1016/j.gpeds.2025.100292","DOIUrl":"10.1016/j.gpeds.2025.100292","url":null,"abstract":"<div><div>Bone health during childhood is critical for proper skeletal development and long-term quality of life. The process of bone formation relies on a balance of mineralization and cellular activity, which is regulated by oxidative stress (OS). While physiological levels of reactive oxygen species (ROS) are important for normal bone cell function and homeostasis, excessive OS can contribute to the development of bone diseases, such as osteoarthritis and osteoporosis. Enzymes like xanthine oxidoreductase are involved in amplifying ROS production, which can lead to cartilage degradation and disrupted bone remodeling. Despite increasing recognition of OS as a risk factor in adult skeletal health, its impact on fetal and neonatal bone development remains underexplored. In vitro and animal model studies, including those using free radicals exposure, have been performed to understand how OS impairs osteogenesis.</div><div>This review examines the role of OS in perinatal bone development analyzing key environmental risk factors and the potential long-term consequences of early-life redox imbalance on skeletal health.</div><div>The sensitivity of the fetal bone to OS suggests that oxidative damage during this critical period can result in impaired bone growth, low birth weight, and long-term skeletal disorders. Oxidative stress interferes with osteoblast differentiation, enhances adipocyte formation from mesenchymal stem cells, and stimulates osteoclast activity, leading to bone resorption. Clinical studies on the impact of OS on neonatal bone metabolism remain limited. Identifying key risk factors for early-life redox imbalance could be crucial in developing potential antioxidant therapies to support skeletal health during childhood</div></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"14 ","pages":"Article 100292"},"PeriodicalIF":0.0,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145048867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-03DOI: 10.1016/j.gpeds.2025.100291
Francesca Saretta , Laura Polloni , Francesco Cavallin , Giuseppe De Bernardo , Paolo Ernesto Villani , Rossana Schiavo , Daniele Trevisanuto
Aim
To investigate coping strategies, anxiety and self-efficacy among participants in Neonatal Resuscitation Courses for instructors.
Methods
Cross-sectional study. Sixty-four participants in two Neonatal Resuscitation Courses for Instructors were assessed by using validated questionnaires.
Results
Overall, self-efficacy and functional coping strategies were moderate/high, while levels of anxiety were quite low. Self- efficacy was positively correlated with positive attitude (r = 0.29; p = 0.02) and problem solving (r = 0.44; p < 0.01) and inversely correlated with avoidance strategies (r=-0.30; p = 0.01) and anxiety (trait r=-0.47; p < 0.01; state r=-0.35; p = 0.01). Emotional maturity was positively correlated with positive attitude (r = 0.42; p < 0.01) and problem solving (r = 0.45; p < 0.01) and inversely correlated with anxiety (trait -0.51; p < 0.01; state r=-0.34; p = 0.01). Finalization of action was positively correlated with problem solving (r = 0.40; p < 0.01) and inversely correlated with avoidance strategies (r=-0.34; p = 0.01) and trait anxiety (r=-0.32; p = 0.01). Relational fluidity was positively correlated with turning to religion (r = 0.28; p = 0.03) and inversely correlated with avoidance strategies (r=-0.31; p = 0.01), and trait anxiety (r=-0.42; p < 0.01). Context analysis was positively correlated with problem solving (r = 0.34; p = 0.01) and inversely correlated with state anxiety (r=-0.36; p < 0.01). Problem solving was significantly higher in doctors compared to nurses (p = 0.01).
Conclusions
Neonatal resuscitation instructor candidates displayed high self-efficacy and functional coping strategies, with low anxiety levels. This may help professionals to better deal with stressful and demanding situations and reinforce adaptive work management.
目的探讨新生儿复苏指导课程参与者的应对策略、焦虑和自我效能感。MethodsCross-sectional研究。采用有效问卷对两门新生儿复苏课程的64名参与者进行评估。结果总体而言,自我效能感和功能性应对策略处于中高水平,焦虑水平较低。自我效能感与积极态度(r= 0.29; p = 0.02)和问题解决能力(r= 0.44; p < 0.01)呈正相关,与回避策略(r=-0.30; p = 0.01)和焦虑(特质r=-0.47; p < 0.01;状态r=-0.35; p = 0.01)呈负相关。情绪成熟度与积极态度(r = 0.42; p < 0.01)、问题解决能力(r = 0.45; p < 0.01)呈正相关,与焦虑(特质r= -0.51; p < 0.01;状态r=-0.34; p = 0.01)呈负相关。最终行动与问题解决呈正相关(r= 0.40; p < 0.01),与回避策略(r=-0.34; p = 0.01)和特质焦虑(r=-0.32; p = 0.01)呈负相关。关系流动性与宗教信仰正相关(r= 0.28; p = 0.03),与回避策略负相关(r=-0.31; p = 0.01),与特质焦虑负相关(r=-0.42; p < 0.01)。情境分析与问题解决能力呈正相关(r= 0.34; p = 0.01),与状态焦虑呈负相关(r=-0.36; p < 0.01)。医生解决问题的能力显著高于护士(p = 0.01)。结论新生儿复苏指导员候选人表现出较高的自我效能感和功能性应对策略,焦虑水平低。这可以帮助专业人士更好地处理压力和要求高的情况,并加强适应性工作管理。
{"title":"Coping strategies, anxiety and self-efficacy among participants in neonatal resuscitation courses for instructors","authors":"Francesca Saretta , Laura Polloni , Francesco Cavallin , Giuseppe De Bernardo , Paolo Ernesto Villani , Rossana Schiavo , Daniele Trevisanuto","doi":"10.1016/j.gpeds.2025.100291","DOIUrl":"10.1016/j.gpeds.2025.100291","url":null,"abstract":"<div><h3>Aim</h3><div>To investigate coping strategies, anxiety and self-efficacy among participants in Neonatal Resuscitation Courses for instructors.</div></div><div><h3>Methods</h3><div>Cross-sectional study. Sixty-four participants in two Neonatal Resuscitation Courses for Instructors were assessed by using validated questionnaires.</div></div><div><h3>Results</h3><div>Overall, self-efficacy and functional coping strategies were moderate/high, while levels of anxiety were quite low. Self- efficacy was positively correlated with positive attitude (<em>r</em> = 0.29; <em>p</em> = 0.02) and problem solving (<em>r</em> = 0.44; <em>p</em> < 0.01) and inversely correlated with avoidance strategies (<em>r</em>=-0.30; <em>p</em> = 0.01) and anxiety (trait <em>r</em>=-0.47; <em>p</em> < 0.01; state <em>r</em>=-0.35; <em>p</em> = 0.01). Emotional maturity was positively correlated with positive attitude (<em>r</em> = 0.42; <em>p</em> < 0.01) and problem solving (<em>r</em> = 0.45; <em>p</em> < 0.01) and inversely correlated with anxiety (trait -0.51; <em>p</em> < 0.01; state <em>r</em>=-0.34; <em>p</em> = 0.01). Finalization of action was positively correlated with problem solving (<em>r</em> = 0.40; <em>p</em> < 0.01) and inversely correlated with avoidance strategies (<em>r</em>=-0.34; <em>p</em> = 0.01) and trait anxiety (<em>r</em>=-0.32; <em>p</em> = 0.01). Relational fluidity was positively correlated with turning to religion (<em>r</em> = 0.28; <em>p</em> = 0.03) and inversely correlated with avoidance strategies (<em>r</em>=-0.31; <em>p</em> = 0.01), and trait anxiety (<em>r</em>=-0.42; <em>p</em> < 0.01). Context analysis was positively correlated with problem solving (<em>r</em> = 0.34; <em>p</em> = 0.01) and inversely correlated with state anxiety (<em>r</em>=-0.36; <em>p</em> < 0.01). Problem solving was significantly higher in doctors compared to nurses (<em>p</em> = 0.01).</div></div><div><h3>Conclusions</h3><div>Neonatal resuscitation instructor candidates displayed high self-efficacy and functional coping strategies, with low anxiety levels. This may help professionals to better deal with stressful and demanding situations and reinforce adaptive work management.</div></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"14 ","pages":"Article 100291"},"PeriodicalIF":0.0,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145019389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-08-27DOI: 10.1016/j.gpeds.2025.100288
Pietro Ferrara , Margherita Zona , Ignazio Cammisa , Ida Giardino , Maria Pastore , Mehmet Vural , Massimo Pettoello-Mantovani , Francesca Scaltrito , Clara Pettoello-Mantovani
Witness Protection Programs are indispensable tools in the fight against organized crime, designed to safeguard individuals whose testimonies are crucial for justice. While these programs have demonstrated remarkable success in ensuring the physical safety of adult witnesses, the profound and often unaddressed challenges faced by accompanying children and adolescents represent a critical oversight. This article examines the multifaceted psychosocial, familial, educational, and societal hurdles encountered by children and adolescents relocated within western witness protection programs, focusing in particular on Europe and the US. Drawing upon existing literature, this report elucidates the cumulative trauma, identity disruption, social isolation, and educational instability inherent in their experiences. The analysis reveals a historical underestimation of children's unique vulnerabilities and rights within these programs. Recommendations emphasize the urgent need for a paradigm shift towards child-centric and family-focused western witness protection programs, advocating for holistic assessment, integrated mental health services, prioritized educational continuity, proactive social integration strategies, community engagement, enhanced professional training, and robust long-term research to ensure the comprehensive well-being of this exceptionally vulnerable population.
{"title":"The unseen burden: Challenges by children and adolescents in witness protection programs in western countries","authors":"Pietro Ferrara , Margherita Zona , Ignazio Cammisa , Ida Giardino , Maria Pastore , Mehmet Vural , Massimo Pettoello-Mantovani , Francesca Scaltrito , Clara Pettoello-Mantovani","doi":"10.1016/j.gpeds.2025.100288","DOIUrl":"10.1016/j.gpeds.2025.100288","url":null,"abstract":"<div><div>Witness Protection Programs are indispensable tools in the fight against organized crime, designed to safeguard individuals whose testimonies are crucial for justice. While these programs have demonstrated remarkable success in ensuring the physical safety of adult witnesses, the profound and often unaddressed challenges faced by accompanying children and adolescents represent a critical oversight. This article examines the multifaceted psychosocial, familial, educational, and societal hurdles encountered by children and adolescents relocated within western witness protection programs, focusing in particular on Europe and the US. Drawing upon existing literature, this report elucidates the cumulative trauma, identity disruption, social isolation, and educational instability inherent in their experiences. The analysis reveals a historical underestimation of children's unique vulnerabilities and rights within these programs. Recommendations emphasize the urgent need for a paradigm shift towards child-centric and family-focused western witness protection programs, advocating for holistic assessment, integrated mental health services, prioritized educational continuity, proactive social integration strategies, community engagement, enhanced professional training, and robust long-term research to ensure the comprehensive well-being of this exceptionally vulnerable population.</div></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"14 ","pages":"Article 100288"},"PeriodicalIF":0.0,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144926030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-08-25DOI: 10.1016/j.gpeds.2025.100287
Pietro Ferrara , Margherita Zona , Ida Giardino , Francesca Scaltrito , Clara Pettoello-Mantovani , Ignazio Cammisa
Children exposed to war confront a distinct array of adversities that extend far beyond the immediate threats of violence and displacement. While the direct consequences—such as physical harm, the loss of loved ones, and the destruction of homes—are profoundly distressing, the more insidious and enduring damage often stems from the disruption of critical developmental processes. Armed conflict undermines the foundational elements required for healthy childhood development, including emotional security, consistent caregiving, education, accessible healthcare, stable social networks, and physical safety. The psychological impact of living in, or fleeing from, conflict zones infiltrates all aspects of a child's life. The breakdown of community infrastructure, forced displacement, and prolonged uncertainty severely limit opportunities for peer interaction, structured play, and social learning—experiences that are vital for shaping self-concept, empathy, and emotional regulation. In environments where fear, mistrust, and violence become normalized, children may struggle to form secure attachments or to envision a hopeful future. It is widely recognized that environmental and contextual factors exert a profound influence on children's developmental trajectories, encompassing cognitive, emotional, and physical domains. Research consistently highlights the role of neighborhood safety, access to healthcare and education, and socioeconomic stability in shaping developmental outcomes. At the neurobiological level, chronic exposure to stress activates regulatory systems such as the hypothalamic–pituitary–adrenal (HPA) axis, which, when persistently engaged, can interfere with brain maturation. This dysregulation is often associated with impairments in memory, attention, language acquisition, and executive functioning, and with increased susceptibility to internalizing disorders such as post-traumatic stress disorder (PTSD), anxiety, depression, and attachment-related difficulties.
Physiologically, prolonged stress can weaken immune function, disturb sleep patterns, hinder somatic growth, and elevate the risk of both acute health problems and chronic diseases. The pervasive and multi-dimensional impact of war on children calls not only for academic inquiry but also for immediate ethical and policy responses. This article emphasizes that a nuanced understanding of trauma's effects across developmental systems is critical to inform targeted, trauma-responsive interventions.
The aim is to raise attention on the importance of establishing effective strategies, which must prioritize not only the treatment of individual symptoms but also broader efforts aimed at prevention and systemic recovery, thereby fostering resilience and contributing to the long-term rehabilitation of communities affected by conflict.
{"title":"The silent wounds of war: Psycho-physical impacts and international legal implications for children in conflict zones","authors":"Pietro Ferrara , Margherita Zona , Ida Giardino , Francesca Scaltrito , Clara Pettoello-Mantovani , Ignazio Cammisa","doi":"10.1016/j.gpeds.2025.100287","DOIUrl":"10.1016/j.gpeds.2025.100287","url":null,"abstract":"<div><div>Children exposed to war confront a distinct array of adversities that extend far beyond the immediate threats of violence and displacement. While the direct consequences—such as physical harm, the loss of loved ones, and the destruction of homes—are profoundly distressing, the more insidious and enduring damage often stems from the disruption of critical developmental processes. Armed conflict undermines the foundational elements required for healthy childhood development, including emotional security, consistent caregiving, education, accessible healthcare, stable social networks, and physical safety. The psychological impact of living in, or fleeing from, conflict zones infiltrates all aspects of a child's life. The breakdown of community infrastructure, forced displacement, and prolonged uncertainty severely limit opportunities for peer interaction, structured play, and social learning—experiences that are vital for shaping self-concept, empathy, and emotional regulation. In environments where fear, mistrust, and violence become normalized, children may struggle to form secure attachments or to envision a hopeful future. It is widely recognized that environmental and contextual factors exert a profound influence on children's developmental trajectories, encompassing cognitive, emotional, and physical domains. Research consistently highlights the role of neighborhood safety, access to healthcare and education, and socioeconomic stability in shaping developmental outcomes. At the neurobiological level, chronic exposure to stress activates regulatory systems such as the hypothalamic–pituitary–adrenal (HPA) axis, which, when persistently engaged, can interfere with brain maturation. This dysregulation is often associated with impairments in memory, attention, language acquisition, and executive functioning, and with increased susceptibility to internalizing disorders such as post-traumatic stress disorder (PTSD), anxiety, depression, and attachment-related difficulties.</div><div>Physiologically, prolonged stress can weaken immune function, disturb sleep patterns, hinder somatic growth, and elevate the risk of both acute health problems and chronic diseases. The pervasive and multi-dimensional impact of war on children calls not only for academic inquiry but also for immediate ethical and policy responses. This article emphasizes that a nuanced understanding of trauma's effects across developmental systems is critical to inform targeted, trauma-responsive interventions.</div><div>The aim is to raise attention on the importance of establishing effective strategies, which must prioritize not only the treatment of individual symptoms but also broader efforts aimed at prevention and systemic recovery, thereby fostering resilience and contributing to the long-term rehabilitation of communities affected by conflict.</div></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"14 ","pages":"Article 100287"},"PeriodicalIF":0.0,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145004422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-08-20DOI: 10.1016/j.gpeds.2025.100286
Neboija Kavaric , Joseph Haddad , Massimo Pettoello-Mantovani
The Charter was jointly developed by EPA-UNEPSA and the International Pediatric Association (IPA) through the contributions of ideas and recommendations from presidents and delegates of European National Pediatric Societies who participated in the 2nd EPA-UNEPSA Hot Topics International Meeting held in Budva, Montenegro, on June 12, 2025 in collaboration with the Association for Preventive Pediatrics of Montenegro,: Giuseppe Buonocore, former President, Italian Academy of Pediatrics; Robert Cohen, President, Conseil National Professionnel de Pédiatrie, Association Française de Pédiatrie Ambulatoire; Pietro Ferrara vice-President, Italian Society of Pediatrics; Hilary Hoey, former President, Faculty of Paediatrics, Royal College Physicians Ireland; Esin Koc, President, Turkish Neonatal Society & the Union of European Neonatal and Perinatal Societies (UENPS); Georgios Konstantinidis, President, Serbian Pediatric Association; Georgina Kuli Lito, President, Albanian Society of Pediatrics; Hajrija Maksić, President, BIH Pediatric Association; Aida Mujkić, President, Pediatric Society of Croatia; Leyla Namazova, President UPR; Tudor Pop, President, Romanian Society of Preventive Pediatrics; Beiqi Ramus, President, Kosovo Pediatric Association; Aspazija Sofijanova, President, N.Macedonia Pediatric Association; Eli Somekh, former President, Israeli Pediatric Association; Tarana Taghi-zada, President, Azerbaijan Pediatric Association & Vice president, Eurasian Federation Children's Doctors; Stephen Turner, President, Royal College of Paediatrics and Child Health, UK; Mehmet Vural, former President, Turkish Pediatric Association. The International Pediatric Association (IPA) and EPA-UNEPSA gratefully acknowledge their invaluable contributions.
{"title":"Montenegro Charter for the protection and recovery of children in disasters","authors":"Neboija Kavaric , Joseph Haddad , Massimo Pettoello-Mantovani","doi":"10.1016/j.gpeds.2025.100286","DOIUrl":"10.1016/j.gpeds.2025.100286","url":null,"abstract":"<div><div>The Charter was jointly developed by EPA-UNEPSA and the International Pediatric Association (IPA) through the contributions of ideas and recommendations from presidents and delegates of European National Pediatric Societies who participated in the 2nd EPA-UNEPSA Hot Topics International Meeting held in Budva, Montenegro, on June 12, 2025 in collaboration with the Association for Preventive Pediatrics of Montenegro,: Giuseppe Buonocore, former President, Italian Academy of Pediatrics; Robert Cohen, President, Conseil National Professionnel de Pédiatrie, Association Française de Pédiatrie Ambulatoire; Pietro Ferrara vice-President, Italian Society of Pediatrics; Hilary Hoey, former President, Faculty of Paediatrics, Royal College Physicians Ireland; Esin Koc, President, Turkish Neonatal Society & the Union of European Neonatal and Perinatal Societies (UENPS); Georgios Konstantinidis, President, Serbian Pediatric Association; Georgina Kuli Lito, President, Albanian Society of Pediatrics; Hajrija Maksić, President, BIH Pediatric Association; Aida Mujkić, President, Pediatric Society of Croatia; Leyla Namazova, President UPR; Tudor Pop, President, Romanian Society of Preventive Pediatrics; Beiqi Ramus, President, Kosovo Pediatric Association; Aspazija Sofijanova, President, N.Macedonia Pediatric Association; Eli Somekh, former President, Israeli Pediatric Association; Tarana Taghi-zada, President, Azerbaijan Pediatric Association & Vice president, Eurasian Federation Children's Doctors; Stephen Turner, President, Royal College of Paediatrics and Child Health, UK; Mehmet Vural, former President, Turkish Pediatric Association. The International Pediatric Association (IPA) and EPA-UNEPSA gratefully acknowledge their invaluable contributions.</div></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"14 ","pages":"Article 100286"},"PeriodicalIF":0.0,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144890729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-08-15DOI: 10.1016/j.gpeds.2025.100285
Clara Pettoello-Mantovani , Margherita Zona , Francesca Scaltrito , Ignazio Cammisa , Ida Giardino , Pietro Ferrara
This article examines the unique vulnerability of children in armed conflict, emphasizing the interplay between their developmental stage, inherent dependency, and evolving legal status. It explores the international legal framework for child protection, which integrates International Humanitarian Law, International Human Rights Law, and International Criminal Law to mitigate the impacts of conflict and ensure accountability for violations. Despite the existence of robust legal instruments, a persistent gap remains between legal norms and their effective implementation, resulting in ongoing harm to children. The article highlights how international law not only prohibits acts such as killing, maiming, and attacks on schools and hospitals but also mandates obligations for recovery, reintegration, and access to health and education—implicitly addressing the psycho-physical harm children endure. Arguing that legal understanding must extend beyond legal professionals to include healthcare providers, the article calls for interdisciplinary collaboration to protect children more effectively. It concludes by advocating for the integration of Mental Health and Psychosocial Support (MHPSS) as an explicit and adequately resourced component of the right to health in humanitarian responses, to address the full spectrum of children's needs in conflict settings.
{"title":"International legal implications for children in conflict zones","authors":"Clara Pettoello-Mantovani , Margherita Zona , Francesca Scaltrito , Ignazio Cammisa , Ida Giardino , Pietro Ferrara","doi":"10.1016/j.gpeds.2025.100285","DOIUrl":"10.1016/j.gpeds.2025.100285","url":null,"abstract":"<div><div>This article examines the unique vulnerability of children in armed conflict, emphasizing the interplay between their developmental stage, inherent dependency, and evolving legal status. It explores the international legal framework for child protection, which integrates International Humanitarian Law, International Human Rights Law, and International Criminal Law to mitigate the impacts of conflict and ensure accountability for violations. Despite the existence of robust legal instruments, a persistent gap remains between legal norms and their effective implementation, resulting in ongoing harm to children. The article highlights how international law not only prohibits acts such as killing, maiming, and attacks on schools and hospitals but also mandates obligations for recovery, reintegration, and access to health and education—implicitly addressing the psycho-physical harm children endure. Arguing that legal understanding must extend beyond legal professionals to include healthcare providers, the article calls for interdisciplinary collaboration to protect children more effectively. It concludes by advocating for the integration of Mental Health and Psychosocial Support (MHPSS) as an explicit and adequately resourced component of the right to health in humanitarian responses, to address the full spectrum of children's needs in conflict settings.</div></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"14 ","pages":"Article 100285"},"PeriodicalIF":0.0,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144887497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-08-14DOI: 10.1016/j.gpeds.2025.100284
Josiane G Luiz , Évelim Leal de Freitas Dantas Gomes , Manoella Cavalcante de Andrade , Dirceu Costa
Background
Exercise restrictions due to asthma are associated with a sedentary lifestyle and reduced physical activity. Based on the limited data available in the literature, improvements in motor proficiency among individuals with respiratory diseases may be related to increased physical activity and better performance in activities of daily living. Therefore, the aim of this study was to evaluate motor proficiency and its association with aerobic capacity in children and adolescents with asthma.
Methods
A cross-sectional study was conducted. Motor proficiency was evaluated using the Movement Assessment Battery for Children – 2nd edition (MABC-2). Aerobic capacity was assessed using the Modified Shuttle Walk Test (MSWT). Asthma control was determined using the Asthma Control Questionnaire (ACQ6).
Results
Fifty participants not engaged in regular physical activity (25 with asthma and 25 controls) were evaluated. The mean age was 7.7 ± 2.65 years in the asthma group (AG) and 10.9 ± 3.89 years in the control group (CG). Both groups performed below predicted values in the MSWT (58.7 ± 21.3 % AG and 66.8 ± 29.2 % CG). The AG performed significantly worse than the CG on the aiming and catching subscale of the MABC-2 (15.4 ± 5.23 and 20.1 ± 7.06, p = 0.01, respectively). Moreover, a moderate negative correlation was found between manual dexterity and asthma control (r = -0.51, p = 0.02). Each 9.79-point increase in the MABC-2 manual dexterity subscale was associated with a 1.72-point reduction in the ACQ6.
Conclusions
Low aerobic capacity appears to negatively impact balance, and poor asthma control appears to negatively affect manual dexterity in the AG. Moreover, the AG had worse performance in aiming and catching compared to the CG.
背景:哮喘引起的运动限制与久坐不动的生活方式和体力活动减少有关。基于文献中有限的数据,呼吸系统疾病患者运动能力的提高可能与体力活动的增加和日常生活活动的改善有关。因此,本研究的目的是评估儿童和青少年哮喘患者的运动熟练程度及其与有氧能力的关系。方法采用横断面研究。运动能力评估使用儿童运动评估电池-第二版(MABC-2)。使用改良穿梭行走测试(MSWT)评估有氧能力。采用哮喘控制问卷(Asthma control Questionnaire, ACQ6)确定哮喘控制情况。结果对50名不从事常规体育活动的参与者(哮喘患者25名,对照组25名)进行了评估。哮喘组(AG)平均年龄7.7±2.65岁,对照组(CG)平均年龄10.9±3.89岁。两组的MSWT均低于预测值(58.7±21.3% AG和66.8±29.2% CG)。在MABC-2的瞄准和捕获分量表上,AG组的得分分别为15.4±5.23和20.1±7.06,p = 0.01,显著低于CG组。此外,手灵巧度与哮喘控制之间存在中度负相关(r = -0.51, p = 0.02)。MABC-2手灵巧子量表每增加9.79分,ACQ6就会减少1.72分。结论有氧能力缓慢会对平衡产生负面影响,哮喘控制不佳会对手灵巧性产生负面影响。此外,AG在瞄准和捕捉方面的表现也比CG差。
{"title":"Analysis of the motor proficiency and physical capacity of asthmatic children and adolescents: A cross-sectional study","authors":"Josiane G Luiz , Évelim Leal de Freitas Dantas Gomes , Manoella Cavalcante de Andrade , Dirceu Costa","doi":"10.1016/j.gpeds.2025.100284","DOIUrl":"10.1016/j.gpeds.2025.100284","url":null,"abstract":"<div><h3>Background</h3><div>Exercise restrictions due to asthma are associated with a sedentary lifestyle and reduced physical activity. Based on the limited data available in the literature, improvements in motor proficiency among individuals with respiratory diseases may be related to increased physical activity and better performance in activities of daily living. Therefore, the aim of this study was to evaluate motor proficiency and its association with aerobic capacity in children and adolescents with asthma.</div></div><div><h3>Methods</h3><div>A cross-sectional study was conducted. Motor proficiency was evaluated using the Movement Assessment Battery for Children – 2nd edition (MABC-2). Aerobic capacity was assessed using the Modified Shuttle Walk Test (MSWT). Asthma control was determined using the Asthma Control Questionnaire (ACQ6).</div></div><div><h3>Results</h3><div>Fifty participants not engaged in regular physical activity (25 with asthma and 25 controls) were evaluated. The mean age was 7.7 ± 2.65 years in the asthma group (AG) and 10.9 ± 3.89 years in the control group (CG). Both groups performed below predicted values in the MSWT (58.7 ± 21.3 % AG and 66.8 ± 29.2 % CG). The AG performed significantly worse than the CG on the aiming and catching subscale of the MABC-2 (15.4 ± 5.23 and 20.1 ± 7.06, <em>p</em> = 0.01, respectively). Moreover, a moderate negative correlation was found between manual dexterity and asthma control (<em>r</em> = -0.51, <em>p</em> = 0.02). Each 9.79-point increase in the MABC-2 manual dexterity subscale was associated with a 1.72-point reduction in the ACQ6.</div></div><div><h3>Conclusions</h3><div>Low aerobic capacity appears to negatively impact balance, and poor asthma control appears to negatively affect manual dexterity in the AG. Moreover, the AG had worse performance in aiming and catching compared to the CG.</div></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"14 ","pages":"Article 100284"},"PeriodicalIF":0.0,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144907029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Photography has been increasingly explored in data collection processes, as it enriches the process and allows the interviewee to take on the role of protagonist [1]. Among the methods that use images, Photovoice and Photo-Elicitation stand out in qualitative research [2]. The objective of this research was to map the development of Photo-Elicitation and Photovoice methods with adolescent mothers as data collection techniques.
Methods
A scoping review was conducted from August to October 2024. The guiding question formulated was: "How have Photo-Elicitation and Photovoice been developed with adolescent mothers as a data collection method?". The search strategy included LILACS, PubMed, CINAHL, and Web of Science.
Results
A total of 46 articles were found, mostly published in English. Ten were selected after full-text reading.
Conclusion
The literature converges in considering Photo-Elicitation and Photovoice as visual and interactive resources that facilitate the communication of adolescent mothers' experiences.
在数据收集过程中越来越多地探索摄影,因为它丰富了过程,让受访者扮演主角[1]的角色。在使用图像的方法中,Photovoice和Photo-Elicitation在定性研究中脱颖而出。本研究的目的是绘制以青少年母亲为数据收集技术的photoelicitation和Photovoice方法的发展图。方法于2024年8月至10月进行范围综述。提出的指导性问题是:“photoelicitation和Photovoice是如何与青少年母亲一起发展成为一种数据收集方法的?”搜索策略包括LILACS、PubMed、CINAHL和Web of Science。结果共收录文献46篇,以英文发表为主。全文阅读后选出10个。结论文献一致认为photoelicitation和Photovoice是促进青春期母亲经验交流的视觉和互动资源。
{"title":"The use of photography for qualitative data collection with adolescent mothers: a scoping review","authors":"Daniela de Castro Barbosa Leonello , Giovanna Ushirobira Souza , Rhyquelle Rhibna Neris , Giovanna Cristina Machado Kayzuka , Marina Prado de Souza , Adriana Moraes Leite","doi":"10.1016/j.gpeds.2025.100283","DOIUrl":"10.1016/j.gpeds.2025.100283","url":null,"abstract":"<div><h3>Introduction</h3><div>Photography has been increasingly explored in data collection processes, as it enriches the process and allows the interviewee to take on the role of protagonist [1]. Among the methods that use images, <em>Photovoice</em> and Photo-Elicitation stand out in qualitative research [2]. The objective of this research was to map the development of Photo-Elicitation and <em>Photovoice</em> methods with adolescent mothers as data collection techniques.</div></div><div><h3>Methods</h3><div>A scoping review was conducted from August to October 2024. The guiding question formulated was: \"How have Photo-Elicitation and <em>Photovoice</em> been developed with adolescent mothers as a data collection method?\". The search strategy included LILACS, PubMed, CINAHL, and <em>Web of Science</em>.</div></div><div><h3>Results</h3><div>A total of 46 articles were found, mostly published in English. Ten were selected after full-text reading.</div></div><div><h3>Conclusion</h3><div>The literature converges in considering Photo-Elicitation and <em>Photovoice</em> as visual and interactive resources that facilitate the communication of adolescent mothers' experiences.</div></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"14 ","pages":"Article 100283"},"PeriodicalIF":0.0,"publicationDate":"2025-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144860722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-08-06DOI: 10.1016/j.gpeds.2025.100282
Raymen R. Assaf , Theodore Heyming , Tricia Morphew , Kellie Bacon , Shelby Shelton , Jason A. Douglas
Objective
To describe the relationship between neighborhood-level repression-adverse childhood experiences (ACEs) (family member incarceration, community violence, discrimination), food and housing insecurity, and pediatric emergency department (ED) utilization.
Methods
The measured exposures were food/housing insecurity, repression-ACEs, and childhood opportunity index (COI 3.0) based on caregiver/patient surveys and home address. The primary outcome was ED visits 12 months before and after the ED index visit. Multivariable regression models examined associations between the exposures and annual ED visit rates per 100 patients, adjusting for potential confounders.
Results
From March 2021 - May 2023 6228 patients (range 0–22 years) had an index ED visit. 64.9 % were Hispanic, 7.0 % Asian, 1.9 % Black, 7.0 % Other/multiple races, and 19.1 % White. Of the participants, 11.6 % had a repression-ACE; 22.3 % food or housing insecurity, and average COI was moderate (53.3, SD = 23.8). Food and housing insecurity were higher among Black (29.0 %) and Hispanic (26.3 %) participants (p < 0.001). Very low to moderate COI was highest in Black (51.3 %) and Hispanic (77.4 %) participants (p < 0.001). Black participants reported the highest repression-ACEs (25.6 %, p < 0.001). In univariate analyses, food insecurity (RR = 1.12, p = 0.07) and housing insecurity (RR = 1.13, p = 0.04) increased the ED visit rate. Experiencing discrimination increased this rate by 27 %, (RR = 1.27, p = 0.02). The effect of violence exposure (p = 0.03) and family member incarceration (p = 0.07) on ED visit rate varied across racial groups.
Conclusions
Repression-ACEs interact with race and ethnicity and social inequities (food/housing insecurity, COI) in shaping ED utilization. Impacts of ACEs on children’s health continue to shape inequities in pediatrics while defining areas for action.
目的探讨社区压抑不良童年经历(ace)(家庭成员监禁、社区暴力、歧视)、食物和住房不安全感与儿科急诊科(ED)使用率之间的关系。方法根据照顾者/患者调查和家庭住址,测量食物/住房不安全感、压抑- ace和童年机会指数(COI 3.0)。主要结局是ED指数访视前后12个月的ED访视。多变量回归模型检验了暴露与每100名患者每年ED就诊率之间的关系,并对潜在的混杂因素进行了调整。结果从2021年3月至2023年5月,6228例患者(年龄0-22岁)进行了指数ED就诊。64.9%为西班牙裔,7.0%为亚洲人,1.9%为黑人,7.0%为其他/多种族,19.1%为白人。在参与者中,11.6%患有抑制性ace;22.3%为食物或住房不安全,平均COI为中等(53.3,SD = 23.8)。黑人(29.0%)和西班牙裔(26.3%)参与者的食物和住房不安全感更高(p <;0.001)。极低至中度COI在黑人(51.3%)和西班牙裔(77.4%)参与者中最高(p <;0.001)。黑人参与者报告了最高的压抑- ace (25.6%, p <;0.001)。在单变量分析中,食品不安全(RR = 1.12, p = 0.07)和住房不安全(RR = 1.13, p = 0.04)增加了急诊科就诊率。遭受歧视使这一比率增加了27% (RR = 1.27, p = 0.02)。暴力暴露(p = 0.03)和家庭成员监禁(p = 0.07)对急诊科就诊率的影响在不同种族之间存在差异。结论压抑性ace与种族、民族和社会不平等(食物/住房不安全,COI)相互作用,影响ED的利用。ace对儿童健康的影响在确定行动领域的同时,继续形成儿科的不平等现象。
{"title":"Food and housing insecurity, adverse childhood experiences, and pediatric emergency department use","authors":"Raymen R. Assaf , Theodore Heyming , Tricia Morphew , Kellie Bacon , Shelby Shelton , Jason A. Douglas","doi":"10.1016/j.gpeds.2025.100282","DOIUrl":"10.1016/j.gpeds.2025.100282","url":null,"abstract":"<div><h3>Objective</h3><div>To describe the relationship between neighborhood-level <em>repression-adverse childhood experiences (ACEs)</em> (family member incarceration, community violence, discrimination), food and housing insecurity, and pediatric emergency department (ED) utilization.</div></div><div><h3>Methods</h3><div>The measured exposures were food/housing insecurity, <em>repression-ACEs</em>, and childhood opportunity index (COI 3.0) based on caregiver/patient surveys and home address. The primary outcome was ED visits 12 months before and after the ED index visit. Multivariable regression models examined associations between the exposures and annual ED visit rates per 100 patients, adjusting for potential confounders.</div></div><div><h3>Results</h3><div>From March 2021 - May 2023 6228 patients (range 0–22 years) had an index ED visit. 64.9 % were Hispanic, 7.0 % Asian, 1.9 % Black, 7.0 % Other/multiple races, and 19.1 % White. Of the participants, 11.6 % had a <em>repression-ACE</em>; 22.3 % food or housing insecurity, and average COI was moderate (53.3, SD = 23.8). Food and housing insecurity were higher among Black (29.0 %) and Hispanic (26.3 %) participants (<em>p</em> < 0.001). Very low to moderate COI was highest in Black (51.3 %) and Hispanic (77.4 %) participants (<em>p</em> < 0.001). Black participants reported the highest <em>repression-ACEs</em> (25.6 %, <em>p</em> < 0.001). In univariate analyses, food insecurity (RR = 1.12, <em>p</em> = 0.07) and housing insecurity (RR = 1.13, <em>p</em> = 0.04) increased the ED visit rate. Experiencing discrimination increased this rate by 27 %, (RR = 1.27, <em>p</em> = 0.02). The effect of violence exposure (<em>p</em> = 0.03) and family member incarceration (<em>p</em> = 0.07) on ED visit rate varied across racial groups.</div></div><div><h3>Conclusions</h3><div><em>Repression-ACEs</em> interact with race and ethnicity and social inequities (food/housing insecurity, COI) in shaping ED utilization. Impacts of ACEs on children’s health continue to shape inequities in pediatrics while defining areas for action.</div></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"13 ","pages":"Article 100282"},"PeriodicalIF":0.0,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144829168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-08-06DOI: 10.1016/j.gpeds.2025.100280
Jayalaxmi Shripati Aihole
Background
A congenital umbilical hernia is a common anomaly seen at birth or during infancy, as a small or large umbilical bulge or swelling due to herniation of the bowel or omentum, mostly requiring medical attention. If umbilical fascial ring fails to close and obliterate after the separation of umbilical cord soon after birth, will be clinically presenting as umbilical hernia. Though spontaneous resolution of umbilical hernia is established fact, but however, duration of it, is still a matter of speculation and what should be done during this waiting period: twiddling the thumbs? and how to avoid surgical interventions or morbidities.
Aim and methods
Hence author proposes here a conservative, non-invasive management technique by mother herself to help to heal her baby from this anomaly during this watchful expectancy period to avoid fatalities.
{"title":"Neonatal umbilical hernia: A simple noninvasive technique","authors":"Jayalaxmi Shripati Aihole","doi":"10.1016/j.gpeds.2025.100280","DOIUrl":"10.1016/j.gpeds.2025.100280","url":null,"abstract":"<div><h3>Background</h3><div>A congenital umbilical hernia is a common anomaly seen at birth or during infancy, as a small or large umbilical bulge or swelling due to herniation of the bowel or omentum, mostly requiring medical attention. If umbilical fascial ring fails to close and obliterate after the separation of umbilical cord soon after birth, will be clinically presenting as umbilical hernia. Though spontaneous resolution of umbilical hernia is established fact, but however, duration of it, is still a matter of speculation and what should be done during this waiting period: twiddling the thumbs? and how to avoid surgical interventions or morbidities.</div></div><div><h3>Aim and methods</h3><div>Hence author proposes here a conservative, non-invasive management technique by mother herself to help to heal her baby from this anomaly during this watchful expectancy period to avoid fatalities.</div></div>","PeriodicalId":73173,"journal":{"name":"Global pediatrics","volume":"13 ","pages":"Article 100280"},"PeriodicalIF":0.0,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144809608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}