Aslıhan Yılmaz Çebi, Bilge Batu Oto, Oğuzhan Kılıçarslan, Ahmet Murat Sarıcı
Purpose: To report an occult intraocular foreign body mimicking choroidal melanoma.
Methods: Medical records and imagings of the patient were retrospectively reviewed.
Case description: A 76-year-old male was referred to our ocular oncology clinic with a suspicious hyperpigmented retinal lesion in the left eye. Biomicroscopy showed aphakia and peripheral iridectomy in the left eye. Fundoscopy revealed a pigmented, slightly elevated lesion on the macula of the left eye surrounded by diffuse atrophy. B-scan ultrasonography showed a preretinal hyperechoic lesion with posterior shadowing. There was no choroidal mass in B-scan or optical coherence tomography (OCT) imaging. On further questioning, it was disclosed that the patient had been hit by an iron fragment in the left eye forty years ago.
Conclusion: Choroidal melanoma is a vision- and life-threatening intraocular malignant tumour. Various neoplastic, degenerative, and inflammatory conditions can simulate choroidal melanoma. A previous history of penetrating ocular trauma should lead the surgeon to re-evaluate a diagnosis of melanoma.
{"title":"Pseudomelanoma: occult intraocular foreign body mimicking choroidal melanoma.","authors":"Aslıhan Yılmaz Çebi, Bilge Batu Oto, Oğuzhan Kılıçarslan, Ahmet Murat Sarıcı","doi":"10.3205/oc000211","DOIUrl":"https://doi.org/10.3205/oc000211","url":null,"abstract":"<p><strong>Purpose: </strong>To report an occult intraocular foreign body mimicking choroidal melanoma.</p><p><strong>Methods: </strong>Medical records and imagings of the patient were retrospectively reviewed.</p><p><strong>Case description: </strong>A 76-year-old male was referred to our ocular oncology clinic with a suspicious hyperpigmented retinal lesion in the left eye. Biomicroscopy showed aphakia and peripheral iridectomy in the left eye. Fundoscopy revealed a pigmented, slightly elevated lesion on the macula of the left eye surrounded by diffuse atrophy. B-scan ultrasonography showed a preretinal hyperechoic lesion with posterior shadowing. There was no choroidal mass in B-scan or optical coherence tomography (OCT) imaging. On further questioning, it was disclosed that the patient had been hit by an iron fragment in the left eye forty years ago.</p><p><strong>Conclusion: </strong>Choroidal melanoma is a vision- and life-threatening intraocular malignant tumour. Various neoplastic, degenerative, and inflammatory conditions can simulate choroidal melanoma. A previous history of penetrating ocular trauma should lead the surgeon to re-evaluate a diagnosis of melanoma.</p>","PeriodicalId":73178,"journal":{"name":"GMS ophthalmology cases","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9979075/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10838267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gelatinous drop-like corneal dystrophy (GDLD) is a rare autosomal recessive corneal dystrophy that has been associated with mutations in the TACSTD2 (M1S1) gene, which is normally expressed in corneal epithelial cells. GDLD is characterized by progressive deposition of amyloid in the corneal stroma with rapid recurrence in grafts after penetrating keratoplasty. We report of case of a patient with GDLD treated bilaterally with staged limbal stem cell transplantation and penetrating keratoplasty that resulted in long-term control of his disease. This case demonstrates that staged allogenic limbal stem cell transplantation, before or after penetrating keratoplasty, can be used to restore vision long-term in GDLD patients.
{"title":"Staged limbal stem cell transplantation and keratoplasty surgeries as a treatment for gelatinous drop-like corneal dystrophy.","authors":"Tayaba N Azher, Amanda C Maltry, Joshua H Hou","doi":"10.3205/oc000210","DOIUrl":"https://doi.org/10.3205/oc000210","url":null,"abstract":"<p><p>Gelatinous drop-like corneal dystrophy (GDLD) is a rare autosomal recessive corneal dystrophy that has been associated with mutations in the TACSTD2 (M1S1) gene, which is normally expressed in corneal epithelial cells. GDLD is characterized by progressive deposition of amyloid in the corneal stroma with rapid recurrence in grafts after penetrating keratoplasty. We report of case of a patient with GDLD treated bilaterally with staged limbal stem cell transplantation and penetrating keratoplasty that resulted in long-term control of his disease. This case demonstrates that staged allogenic limbal stem cell transplantation, before or after penetrating keratoplasty, can be used to restore vision long-term in GDLD patients.</p>","PeriodicalId":73178,"journal":{"name":"GMS ophthalmology cases","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9979074/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10838262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gabriel Castilho Sandoval Barbosa, Leandro C Zacharias, Eduardo A Novais, Ricardo L L Guerra
The concept of retinal autofluorescence (AF) came to light in the 1970s when an autofluorescent signal of optic nerve head drusen (ONHD) was noted prior to the injection of fluorescein dye [1]. Nowadays, several devices offer distinct methods for acquiring short-wave fundus autofluorescence (SW-FAF) images, all of them being clinically useful in assessing the presence of lipofuscin, a naturally occurring ocular fluorophor which reflects the general health of the photoreceptor and retinal pigment epithelium (RPE). Each device provides a different image acquisition method; thus, discrepancies exist in the images obtained. For example, fundus cameras feature a high-energy white flash that streams through a wideband excitation filter and a series of mirrors and apertures to obtain images. On the other hand, confocal scanning laser ophthalmoscope (cSLO) emits a single wavelength, which will only excite fluorophores that absorb light with a peak excitation near that specific wavelength [2]. Broad line fundus image (BLFI) technique is a hybrid of both cSLO and traditional fundus photography. By utilizing line scanning illuminationwith light-emitting diodes (LEDs) and an aperture confocal to the illumination, this system illuminates and detects retinal images in two wavelength ranges: fundus autofluorescence (FAF)-Blue (435–500 nm) and FAF-Green (500–585 nm) [3]. Both are categorized as short-wavelength, but it is well known that green light can reach deeper layers of the retina, being absorbed less by the luteal pigments of themacula, and allowing a better definition of lesions in the underlying RPE. ONHD are a form of calcific degeneration in some of the axons of the optic nerve that may give a swollen-looking appearance, and are usually formed early in life. ONHD are diagnosed with fundoscopic examination, but some casesmay require B-scan ultrasonography, AF, and optical coherence tomography (OCT) to confirm the lesion [4]. The features of ONHD in FAF imaging are well described in many previous publications [4], [5]. Yan et al. [4] recently described the peculiarities of ONHD in FAF-Blue and -Green by using a cSLO system from two different devices. Despite a considerable amount of meaningful information, we were unable to find a description of FAF imaging in ONHD using BLFI technology in the literature. We have recently observed a noticeable disparity in the
{"title":"Enhancing the knowledge in fundus autofluorescence of optic nerve head drusen assessed with broad line fundus imaging technology.","authors":"Gabriel Castilho Sandoval Barbosa, Leandro C Zacharias, Eduardo A Novais, Ricardo L L Guerra","doi":"10.3205/oc000222","DOIUrl":"https://doi.org/10.3205/oc000222","url":null,"abstract":"The concept of retinal autofluorescence (AF) came to light in the 1970s when an autofluorescent signal of optic nerve head drusen (ONHD) was noted prior to the injection of fluorescein dye [1]. Nowadays, several devices offer distinct methods for acquiring short-wave fundus autofluorescence (SW-FAF) images, all of them being clinically useful in assessing the presence of lipofuscin, a naturally occurring ocular fluorophor which reflects the general health of the photoreceptor and retinal pigment epithelium (RPE). Each device provides a different image acquisition method; thus, discrepancies exist in the images obtained. For example, fundus cameras feature a high-energy white flash that streams through a wideband excitation filter and a series of mirrors and apertures to obtain images. On the other hand, confocal scanning laser ophthalmoscope (cSLO) emits a single wavelength, which will only excite fluorophores that absorb light with a peak excitation near that specific wavelength [2]. Broad line fundus image (BLFI) technique is a hybrid of both cSLO and traditional fundus photography. By utilizing line scanning illuminationwith light-emitting diodes (LEDs) and an aperture confocal to the illumination, this system illuminates and detects retinal images in two wavelength ranges: fundus autofluorescence (FAF)-Blue (435–500 nm) and FAF-Green (500–585 nm) [3]. Both are categorized as short-wavelength, but it is well known that green light can reach deeper layers of the retina, being absorbed less by the luteal pigments of themacula, and allowing a better definition of lesions in the underlying RPE. ONHD are a form of calcific degeneration in some of the axons of the optic nerve that may give a swollen-looking appearance, and are usually formed early in life. ONHD are diagnosed with fundoscopic examination, but some casesmay require B-scan ultrasonography, AF, and optical coherence tomography (OCT) to confirm the lesion [4]. The features of ONHD in FAF imaging are well described in many previous publications [4], [5]. Yan et al. [4] recently described the peculiarities of ONHD in FAF-Blue and -Green by using a cSLO system from two different devices. Despite a considerable amount of meaningful information, we were unable to find a description of FAF imaging in ONHD using BLFI technology in the literature. We have recently observed a noticeable disparity in the","PeriodicalId":73178,"journal":{"name":"GMS ophthalmology cases","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10413383/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10000996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-18eCollection Date: 2022-01-01DOI: 10.3205/oc000206
Siddhi Goel, Arpit Sharma, Rajesh Sinha
Objective: To report a case of recalcitrant fungal keratitis successfully managed with topical caspofungin acetate in North India.
Methods: Case report and literature review.
Results: An 18-year-old male patient presented with complaints of redness, watering, pain and diminution of vision in the right eye and was referred to our centre as a case of corneal ulcer. The patient was examined and found to have a near total epithelial defect, with corneal infiltrates approximately 8x8 mm. A provisional diagnosis of polymicrobial keratitis was made based on corneal scraping suggestive of Staphylococcus aureus and confocal scan revealing fungal hyphae. The patient failed to respond to topical voriconazole 1%, natamycin 5% and moxifloxacin hydrochloride 0.5% with oral voriconazole. In view of the poor response to these drugs, the patient was subsequently administered topical caspofungin 0.5% in place of natamycin and continued on topical and oral voriconazole, in addition to topical moxifloxacin and cycloplegics, which finally led to healing with minimal scarring. The patient attained a best corrected visual acuity (BCVA) of 6/12.
Conclusion: Topical caspofungin may be used as a useful and effective alternative in cases of recalcitrant fungal keratitis. It may result in healing with minimal scarring.
{"title":"Successful management of recalcitrant fungal keratitis with topical caspofungin.","authors":"Siddhi Goel, Arpit Sharma, Rajesh Sinha","doi":"10.3205/oc000206","DOIUrl":"https://doi.org/10.3205/oc000206","url":null,"abstract":"<p><strong>Objective: </strong>To report a case of recalcitrant fungal keratitis successfully managed with topical caspofungin acetate in North India.</p><p><strong>Methods: </strong>Case report and literature review.</p><p><strong>Results: </strong>An 18-year-old male patient presented with complaints of redness, watering, pain and diminution of vision in the right eye and was referred to our centre as a case of corneal ulcer. The patient was examined and found to have a near total epithelial defect, with corneal infiltrates approximately 8x8 mm. A provisional diagnosis of polymicrobial keratitis was made based on corneal scraping suggestive of <i>S</i> <i>tap</i> <i>h</i> <i>ylococcus aureus</i> and confocal scan revealing fungal hyphae. The patient failed to respond to topical voriconazole 1%, natamycin 5% and moxifloxacin hydrochloride 0.5% with oral voriconazole. In view of the poor response to these drugs, the patient was subsequently administered topical caspofungin 0.5% in place of natamycin and continued on topical and oral voriconazole, in addition to topical moxifloxacin and cycloplegics, which finally led to healing with minimal scarring. The patient attained a best corrected visual acuity (BCVA) of 6/12.</p><p><strong>Conclusion: </strong>Topical caspofungin may be used as a useful and effective alternative in cases of recalcitrant fungal keratitis. It may result in healing with minimal scarring.</p>","PeriodicalId":73178,"journal":{"name":"GMS ophthalmology cases","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9577386/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40438174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-28eCollection Date: 2022-01-01DOI: 10.3205/oc000205
Albert John Bromeo, Sweet Jorlene Lerit, Patricia Grulla-Quilendrino, George Michael Sosuan, Edgar Leuenberger
Retinal vascular events may occur as rare complications of glaucoma procedures due to various factors, including exacerbation of ischemia in patients with pre-existing vascular comorbidities, toxic effect of mitomycin-C, and decompression retinopathy. We present the case of a 47-year-old hypertensive male who underwent trabeculectomy for advanced glaucoma in his right eye. At 3 weeks postoperatively, he presented with a drop in visual acuity to light perception with a spike in intraocular pressure. On examination, there was increased bleb vascularity as well as rubeosis. Fundoscopy revealed findings consistent with both central retinal artery occlusion and central retinal vein occlusion. Combined central retinal artery and vein occlusion is a rare retinal vascular condition. Neovascular glaucoma can occur as a sequelae of the ischemic process in the retina. Despite treatment, there is a poor visual prognosis, with the affected eye usually becoming blind from optic atrophy and neovascularization.
{"title":"Combined central retinal artery and vein occlusion following trabeculectomy.","authors":"Albert John Bromeo, Sweet Jorlene Lerit, Patricia Grulla-Quilendrino, George Michael Sosuan, Edgar Leuenberger","doi":"10.3205/oc000205","DOIUrl":"https://doi.org/10.3205/oc000205","url":null,"abstract":"<p><p>Retinal vascular events may occur as rare complications of glaucoma procedures due to various factors, including exacerbation of ischemia in patients with pre-existing vascular comorbidities, toxic effect of mitomycin-C, and decompression retinopathy. We present the case of a 47-year-old hypertensive male who underwent trabeculectomy for advanced glaucoma in his right eye. At 3 weeks postoperatively, he presented with a drop in visual acuity to light perception with a spike in intraocular pressure. On examination, there was increased bleb vascularity as well as rubeosis. Fundoscopy revealed findings consistent with both central retinal artery occlusion and central retinal vein occlusion. Combined central retinal artery and vein occlusion is a rare retinal vascular condition. Neovascular glaucoma can occur as a sequelae of the ischemic process in the retina. Despite treatment, there is a poor visual prognosis, with the affected eye usually becoming blind from optic atrophy and neovascularization.</p>","PeriodicalId":73178,"journal":{"name":"GMS ophthalmology cases","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9285110/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40574969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-10eCollection Date: 2022-01-01DOI: 10.3205/oc000204
Gabriela Pacheco Callirgos, Francisco Javier Valentín Bravo, Pablo Panadero Meseguer, Víctor Manuel Asensio Sánchez
Cavernous hemangioma is the most common benign orbital and vascular tumor in adults. It is mostly located intraconally. Nevertheless, when the location is extraconal, the displacement of the globe is opposite the tumor's position. We describe an unusual presentation of this tumor in a 75-year-old female. The only symptom was the presence of epiphora. In the clinical examination, a mass was palpated on the lower orbital rim of the right eye. The magnetic resonance imaging (MRI) showed a well-circumscribed ovoid mass with a strong T2 hyperintensity and progressive contrast filling in T1. Excisional biopsy was performed, which confirmed the diagnosis of cavernous hemangioma. At five months of follow-up, there was no evidence of new symptoms.
{"title":"Unusual extraconal orbital location of a cavernous hemangioma.","authors":"Gabriela Pacheco Callirgos, Francisco Javier Valentín Bravo, Pablo Panadero Meseguer, Víctor Manuel Asensio Sánchez","doi":"10.3205/oc000204","DOIUrl":"https://doi.org/10.3205/oc000204","url":null,"abstract":"<p><p>Cavernous hemangioma is the most common benign orbital and vascular tumor in adults. It is mostly located intraconally. Nevertheless, when the location is extraconal, the displacement of the globe is opposite the tumor's position. We describe an unusual presentation of this tumor in a 75-year-old female. The only symptom was the presence of epiphora. In the clinical examination, a mass was palpated on the lower orbital rim of the right eye. The magnetic resonance imaging (MRI) showed a well-circumscribed ovoid mass with a strong T2 hyperintensity and progressive contrast filling in T1. Excisional biopsy was performed, which confirmed the diagnosis of cavernous hemangioma. At five months of follow-up, there was no evidence of new symptoms.</p>","PeriodicalId":73178,"journal":{"name":"GMS ophthalmology cases","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9285109/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40572438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-09eCollection Date: 2022-01-01DOI: 10.3205/oc000203
Erhan Özyol, Pelin Özyol
Acute zonal occult outer retinopathy (AZOOR) is a rare condition primarily affecting the outer retina based on electrophysiologic studies. In addition to characteristic fundus appearance, spectral domain optical coherence tomography and fundus autofluorescence are unique in diagnosing AZOOR. There are a few reports on optical coherence tomography anjiography (OCTA) in AZOOR disease. In this report, we present a case using multimodal imaging including OCTA and treatment response to combined systemic antiviral, antiinflammatory, and immunosuppressive drugs. En-face OCTA outer retinal slab may provide useful tips for diagnosis and treatment response.
{"title":"Acute zonal occult outer retinopathy: optical coherence tomography angiography findings and treatment response.","authors":"Erhan Özyol, Pelin Özyol","doi":"10.3205/oc000203","DOIUrl":"https://doi.org/10.3205/oc000203","url":null,"abstract":"<p><p>Acute zonal occult outer retinopathy (AZOOR) is a rare condition primarily affecting the outer retina based on electrophysiologic studies. In addition to characteristic fundus appearance, spectral domain optical coherence tomography and fundus autofluorescence are unique in diagnosing AZOOR. There are a few reports on optical coherence tomography anjiography (OCTA) in AZOOR disease. In this report, we present a case using multimodal imaging including OCTA and treatment response to combined systemic antiviral, antiinflammatory, and immunosuppressive drugs. En-face OCTA outer retinal slab may provide useful tips for diagnosis and treatment response.</p>","PeriodicalId":73178,"journal":{"name":"GMS ophthalmology cases","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9285114/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40572443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-07eCollection Date: 2022-01-01DOI: 10.3205/oc000201
Anubhav Garg, Bryon R McKay, Carolina L M Francisconi, Rajeev H Muni
Objective: To review a case of toxoplasmosis chorioretinitis mimicking cytomegalovirus retinitis in an immunocompromised patient following bone marrow transplantation.
Methods: Retrospective chart review of a 14-year-old female who had a history of leukemia and allogeneic bone marrow transplants prior to her ocular symptoms.
Results: Anterior chamber fluid analysis was positive for Toxoplasma gondii. The patient responded well when cytomegalovirus retinitis treatment was switched to intravitreal clindamycin with systemic sulfadiazine and prednisone.
Conclusions: This case demonstrates the challenges of diagnosing and treating retinal infections in immunocompromised patients as they may present with atypical findings that mimic other pathologies and may have contraindications against standard treatment.
{"title":"Toxoplasmosis chorioretinitis mimicking cytomegalovirus retinitis in an immunocompromised pediatric patient following bone marrow transplantation.","authors":"Anubhav Garg, Bryon R McKay, Carolina L M Francisconi, Rajeev H Muni","doi":"10.3205/oc000201","DOIUrl":"https://doi.org/10.3205/oc000201","url":null,"abstract":"<p><strong>Objective: </strong>To review a case of toxoplasmosis chorioretinitis mimicking cytomegalovirus retinitis in an immunocompromised patient following bone marrow transplantation.</p><p><strong>Methods: </strong>Retrospective chart review of a 14-year-old female who had a history of leukemia and allogeneic bone marrow transplants prior to her ocular symptoms.</p><p><strong>Results: </strong>Anterior chamber fluid analysis was positive for <i>Toxoplasma gondii</i>. The patient responded well when cytomegalovirus retinitis treatment was switched to intravitreal clindamycin with systemic sulfadiazine and prednisone.</p><p><strong>Conclusions: </strong>This case demonstrates the challenges of diagnosing and treating retinal infections in immunocompromised patients as they may present with atypical findings that mimic other pathologies and may have contraindications against standard treatment.</p>","PeriodicalId":73178,"journal":{"name":"GMS ophthalmology cases","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9284721/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40572439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-07eCollection Date: 2022-01-01DOI: 10.3205/oc000202
Ashok Kumar, Sandeep Shankar, Divya Kochhar, Amit Arora, Kapil Kumar
Ocular manifestations of leukemia are often bilateral and involve all ocular structures with non-specific features like retinal hemorrhages, cotton wool spots and choroidal infiltrates. We report a rare, atypical initial presentation of acute myeloid leukemia with unilateral central retinal vein occlusion in a middle-aged male. This case will raise awareness among ophthalmologists to recognize and diagnose underlying systemic disease early and decrease systemic morbidity in consultation with a hematologist.
{"title":"Acute myeloid leukemia presenting as unilateral central retinal vein occlusion.","authors":"Ashok Kumar, Sandeep Shankar, Divya Kochhar, Amit Arora, Kapil Kumar","doi":"10.3205/oc000202","DOIUrl":"https://doi.org/10.3205/oc000202","url":null,"abstract":"<p><p>Ocular manifestations of leukemia are often bilateral and involve all ocular structures with non-specific features like retinal hemorrhages, cotton wool spots and choroidal infiltrates. We report a rare, atypical initial presentation of acute myeloid leukemia with unilateral central retinal vein occlusion in a middle-aged male. This case will raise awareness among ophthalmologists to recognize and diagnose underlying systemic disease early and decrease systemic morbidity in consultation with a hematologist.</p>","PeriodicalId":73178,"journal":{"name":"GMS ophthalmology cases","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9285115/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40572441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-20eCollection Date: 2022-01-01DOI: 10.3205/oc000200
Mukesh Jain, Deepika C Parameswarappa
We report a case of a 65-year-old female who presented to us with diminution of vision in the right eye. She was only able to perceive light in the right eye, and the left eye had a vision of 20/20, N6. Anterior segment examination in both eyes was unremarkable except for senile cataract in the left eye. Posterior segment examination revealed features of choroidal metastasis in both eyes and exudative retinal detachment in the right eye. Multimodal imaging helped in the further confirmation of metastatic lesions. Right-eye fundus autofluorescence showed hyperautofluorescent lesions, ultrasound B-scan showed an elevated mass lesion in the choroid with moderate to high internal echogenicity, and optical coherence tomography showed a lumpy-bumpy appearance of the retinal pigment epithelium as well as an elevated choroidal mass lesion beneath it. On detailed systemic evaluation, the primary site of cancer was found to be the lungs. The patient was referred to a pulmonologist and an oncologist for chemotherapy and further management.
{"title":"Choroidal metastasis as a presenting feature in a metastatic lung carcinoma.","authors":"Mukesh Jain, Deepika C Parameswarappa","doi":"10.3205/oc000200","DOIUrl":"https://doi.org/10.3205/oc000200","url":null,"abstract":"<p><p>We report a case of a 65-year-old female who presented to us with diminution of vision in the right eye. She was only able to perceive light in the right eye, and the left eye had a vision of 20/20, N6. Anterior segment examination in both eyes was unremarkable except for senile cataract in the left eye. Posterior segment examination revealed features of choroidal metastasis in both eyes and exudative retinal detachment in the right eye. Multimodal imaging helped in the further confirmation of metastatic lesions. Right-eye fundus autofluorescence showed hyperautofluorescent lesions, ultrasound B-scan showed an elevated mass lesion in the choroid with moderate to high internal echogenicity, and optical coherence tomography showed a lumpy-bumpy appearance of the retinal pigment epithelium as well as an elevated choroidal mass lesion beneath it. On detailed systemic evaluation, the primary site of cancer was found to be the lungs. The patient was referred to a pulmonologist and an oncologist for chemotherapy and further management.</p>","PeriodicalId":73178,"journal":{"name":"GMS ophthalmology cases","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9285108/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40572442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}