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Unilateral macular neovascularization formation during the follow-up of a 15-year-old boy with Bietti crystalline dystrophy and the successful treatment outcome with a single intravitreal ranibizumab injection. 一名15岁男孩Bietti结晶性营养不良的随访期间单侧黄斑新生血管的形成和单次玻璃体内注射兰珠单抗的成功治疗结果。
Pub Date : 2023-01-01 DOI: 10.3205/oc000214
Mustafa Kayabaşi, Ferdane Ataş, Ali Osman Saatci

Objective: To report the successful outcome with a single intravitreal ranibizumab injection in a 15-year-old boy with Bietti crystalline dystrophy (BCD) who developed a unilateral macular neovascularization (MNV).

Methods: A retrospective case report.

Results: A 15-year-old Caucasian boy with Bietti crystalline dystrophy was diagnosed to have a unilateral MNV a year after the initial examination with the help of multimodal imaging and he was treated with a single intravitreal ranibizumab injection. Five months later, visual acuity improved and anatomically a dry-looking macula was noted.

Conclusion: MNV is among the rare macular complications of BCD. The present case is the third reported pediatric case with MNV in association with BCD and the first pediatric BCD patient who received a vascular endothelial growth factor inhibitor (anti-VEGF) agent.

目的:报告单次玻璃体内注射雷尼单抗治疗15岁男孩Bietti结晶性营养不良(BCD)并发单侧黄斑新生血管(MNV)的成功结果。方法:回顾性病例报告。结果:一名患有Bietti晶体营养不良症的15岁高加索男孩在多模态成像的帮助下进行初步检查一年后被诊断为单侧MNV,并接受单次玻璃体内注射雷尼单抗治疗。5个月后,视力改善,解剖上发现干性黄斑。结论:MNV是BCD罕见的黄斑并发症之一。本病例是第三例报道的小儿MNV合并BCD病例,也是第一例接受血管内皮生长因子抑制剂(抗vegf)治疗的小儿BCD患者。
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引用次数: 1
Unilateral K-F ring in Wilson's disease. Wilson病的单侧K-F环。
Pub Date : 2023-01-01 DOI: 10.3205/oc000216
Shruti P Hegde, Sakthivel Senthil Kumar

Wilson's disease, also called hepatolenticular degeneration, has varied clinical manifestations and poses diagnostic challenges. Kayser-Fleischer ring, when present, is considered pathognomic of Wilson's disease. Although its presence is most commonly seen with the neuro-psychiatric form of the disease, it can also be present in hepatic form and asymptomatic patients. We report a case of unilateral Kayser-Fleischer ring in the normal, functional eye of a patient which subsequently led to the diagnosis of Wilson's disease in the patient. This case also highlights the examination of the normal appearing eye in all the patients presenting with complaints in only one eye.

肝豆状核变性,又称肝豆状核变性,临床表现多样,诊断困难。Kayser-Fleischer环,当存在时,被认为是威尔逊病的病理特征。虽然它的存在是最常见的神经精神形式的疾病,它也可以出现在肝脏形式和无症状的患者。我们报告一例单侧Kayser-Fleischer环在正常,功能眼的病人,随后导致威尔逊病的诊断在病人。本病例也强调了对所有单眼主诉患者的正常眼进行检查。
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引用次数: 0
Microscope integrated OCT (Mi-OCT) guided retrieval of intrastromal corneal foreign body. 显微集成OCT (Mi-OCT)引导下角膜基质内异物取出术。
Pub Date : 2023-01-01 DOI: 10.3205/oc000217
Ashish Markan, Kiran Chandra, Ramandeep Singh, Mohit Dogra

Introduction: To describe the role of microscope integrated optical tomography (Mi-OCT) in removal of intrastromal corneal foreign body.

Methodology: A young male presented with trauma to the right eye with sugarcane stick. Ocular examination revealed two sugarcane particles, approximately 3.5 mm in greatest dimension, embedded in the corneal stroma. For removal of foreign body, Mi-OCT was switched on and the area of interest was focused. Sugarcane particles appeared as hyperreflective structures embedded in the corneal stroma with everted edges of the overlying corneal epithelium and anterior stroma.

Results: Both the sugarcane particles were removed successfully under real time images provided by Mi-OCT without causing any inadvertent damage to the corneal stroma.

Conclusion: Mi-OCT can be used as an adjunct in emergency surgical procedures like removal of intrastromal corneal foreign bodies with accurate precision.

目的:描述显微镜综合光学断层扫描(Mi-OCT)在角膜基质内异物去除中的作用。方法:一位年轻男性,右眼被甘蔗棒刺伤。眼部检查发现2个甘蔗颗粒,最大尺寸约3.5 mm,嵌在角膜基质中。为了去除异物,打开Mi-OCT并聚焦感兴趣的区域。甘蔗颗粒表现为嵌入角膜基质的高反射结构,其上覆角膜上皮和前基质的边缘呈外翻状。结果:在Mi-OCT提供的实时图像下,两种甘蔗颗粒都被成功去除,没有对角膜基质造成任何无意的损伤。结论:在角膜基质内异物取出等急诊手术中,Mi-OCT可作为辅助手段,具有准确的精度。
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引用次数: 0
Self-inflicted bilateral ocular injury with scissors in a psychiatric patient. 精神病人用剪刀自残双眼。
Pub Date : 2023-01-01 DOI: 10.3205/oc000219
Jigyasa Sahu, Ritu Arora, Shweta Vishwanath

A young male was brought to the ophthalmic emergency by his family with severe bleeding from both eyes after self-inflicted injury with scissors in a fit of mania. He had a history of schizophrenia and has been on irregular treatment for the past 10 years. Both eyes were severely damaged with avulsion of all extraocular muscles in one eye and a large corneoscleral laceration in the other. We report this unique case of oedipism or self-enucleation where a sharp instrument was used. Self-inflicted injury to the eyes is a rather uncommon phenomenon described in psychiatric patients. It can range from minor abrasions to severe ocular mutilation and loss of sight. The strict observation of these patients while admitted to the hospital and a multidisciplinary approach to ensure their future safety are imperative.

一名年轻男子在狂躁发作时用剪刀割伤双眼,双眼大量出血,被家人送到眼科急诊室。他有精神分裂症病史,在过去的10年里一直不定期接受治疗。双眼严重受损,一只眼眼外肌全部撕脱,另一只眼角膜巩膜撕裂。我们报告这个独特的俄狄浦斯癖或自我摘除术,其中一个尖锐的工具被使用。在精神病患者中,自我伤害眼睛是一种相当罕见的现象。它的范围从轻微的擦伤到严重的眼部损伤和失明。在入院期间对这些患者进行严格观察,并采取多学科方法确保他们未来的安全,这是当务之急。
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引用次数: 0
Pseudomelanoma: occult intraocular foreign body mimicking choroidal melanoma. 假性黑色素瘤:隐匿的眼内异物,类似脉络膜黑色素瘤。
Pub Date : 2023-01-01 DOI: 10.3205/oc000211
Aslıhan Yılmaz Çebi, Bilge Batu Oto, Oğuzhan Kılıçarslan, Ahmet Murat Sarıcı

Purpose: To report an occult intraocular foreign body mimicking choroidal melanoma.

Methods: Medical records and imagings of the patient were retrospectively reviewed.

Case description: A 76-year-old male was referred to our ocular oncology clinic with a suspicious hyperpigmented retinal lesion in the left eye. Biomicroscopy showed aphakia and peripheral iridectomy in the left eye. Fundoscopy revealed a pigmented, slightly elevated lesion on the macula of the left eye surrounded by diffuse atrophy. B-scan ultrasonography showed a preretinal hyperechoic lesion with posterior shadowing. There was no choroidal mass in B-scan or optical coherence tomography (OCT) imaging. On further questioning, it was disclosed that the patient had been hit by an iron fragment in the left eye forty years ago.

Conclusion: Choroidal melanoma is a vision- and life-threatening intraocular malignant tumour. Various neoplastic, degenerative, and inflammatory conditions can simulate choroidal melanoma. A previous history of penetrating ocular trauma should lead the surgeon to re-evaluate a diagnosis of melanoma.

目的:报告一例模拟脉络膜黑色素瘤的隐匿眼内异物。方法:回顾性分析患者的病历和影像学资料。病例描述:一位76岁男性因左眼可疑的视网膜色素沉着病变被转介到我们的眼科肿瘤诊所。生物显微镜检查显示左眼无晶状体,周围虹膜切除。眼底镜检查显示左眼黄斑处有色素性轻度升高的病变,周围弥漫性萎缩。b超显示视网膜前高回声病变伴后影。b超及光学相干断层扫描(OCT)未见脉络膜肿块。经过进一步询问,医生透露,四十年前,病人的左眼曾被一块铁碎片击中。结论:脉络膜黑色素瘤是一种危及视力和生命的眼内恶性肿瘤。各种肿瘤、退行性疾病和炎症都可以模拟脉络膜黑色素瘤。既往的穿透性眼外伤史应使外科医生重新评估黑色素瘤的诊断。
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引用次数: 0
Staged limbal stem cell transplantation and keratoplasty surgeries as a treatment for gelatinous drop-like corneal dystrophy. 分期角膜缘干细胞移植和角膜移植手术治疗胶质滴状角膜营养不良。
Pub Date : 2023-01-01 DOI: 10.3205/oc000210
Tayaba N Azher, Amanda C Maltry, Joshua H Hou

Gelatinous drop-like corneal dystrophy (GDLD) is a rare autosomal recessive corneal dystrophy that has been associated with mutations in the TACSTD2 (M1S1) gene, which is normally expressed in corneal epithelial cells. GDLD is characterized by progressive deposition of amyloid in the corneal stroma with rapid recurrence in grafts after penetrating keratoplasty. We report of case of a patient with GDLD treated bilaterally with staged limbal stem cell transplantation and penetrating keratoplasty that resulted in long-term control of his disease. This case demonstrates that staged allogenic limbal stem cell transplantation, before or after penetrating keratoplasty, can be used to restore vision long-term in GDLD patients.

凝胶滴状角膜营养不良(GDLD)是一种罕见的常染色体隐性角膜营养不良,与TACSTD2 (M1S1)基因突变有关,该基因通常在角膜上皮细胞中表达。GDLD的特点是角膜基质中淀粉样蛋白的进行性沉积,在穿透性角膜移植术后移植物中迅速复发。我们报告一例患者的GDLD治疗双侧分阶段角膜缘干细胞移植和穿透性角膜移植术,导致长期控制他的疾病。本病例表明,在穿透性角膜移植术之前或之后,分期同种异体角膜缘干细胞移植可用于恢复GDLD患者的长期视力。
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引用次数: 0
Enhancing the knowledge in fundus autofluorescence of optic nerve head drusen assessed with broad line fundus imaging technology. 阔线眼底成像技术提高对视神经头眼底自身荧光的认识。
Pub Date : 2023-01-01 DOI: 10.3205/oc000222
Gabriel Castilho Sandoval Barbosa, Leandro C Zacharias, Eduardo A Novais, Ricardo L L Guerra
The concept of retinal autofluorescence (AF) came to light in the 1970s when an autofluorescent signal of optic nerve head drusen (ONHD) was noted prior to the injection of fluorescein dye [1]. Nowadays, several devices offer distinct methods for acquiring short-wave fundus autofluorescence (SW-FAF) images, all of them being clinically useful in assessing the presence of lipofuscin, a naturally occurring ocular fluorophor which reflects the general health of the photoreceptor and retinal pigment epithelium (RPE). Each device provides a different image acquisition method; thus, discrepancies exist in the images obtained. For example, fundus cameras feature a high-energy white flash that streams through a wideband excitation filter and a series of mirrors and apertures to obtain images. On the other hand, confocal scanning laser ophthalmoscope (cSLO) emits a single wavelength, which will only excite fluorophores that absorb light with a peak excitation near that specific wavelength [2]. Broad line fundus image (BLFI) technique is a hybrid of both cSLO and traditional fundus photography. By utilizing line scanning illuminationwith light-emitting diodes (LEDs) and an aperture confocal to the illumination, this system illuminates and detects retinal images in two wavelength ranges: fundus autofluorescence (FAF)-Blue (435–500 nm) and FAF-Green (500–585 nm) [3]. Both are categorized as short-wavelength, but it is well known that green light can reach deeper layers of the retina, being absorbed less by the luteal pigments of themacula, and allowing a better definition of lesions in the underlying RPE. ONHD are a form of calcific degeneration in some of the axons of the optic nerve that may give a swollen-looking appearance, and are usually formed early in life. ONHD are diagnosed with fundoscopic examination, but some casesmay require B-scan ultrasonography, AF, and optical coherence tomography (OCT) to confirm the lesion [4]. The features of ONHD in FAF imaging are well described in many previous publications [4], [5]. Yan et al. [4] recently described the peculiarities of ONHD in FAF-Blue and -Green by using a cSLO system from two different devices. Despite a considerable amount of meaningful information, we were unable to find a description of FAF imaging in ONHD using BLFI technology in the literature. We have recently observed a noticeable disparity in the
{"title":"Enhancing the knowledge in fundus autofluorescence of optic nerve head drusen assessed with broad line fundus imaging technology.","authors":"Gabriel Castilho Sandoval Barbosa,&nbsp;Leandro C Zacharias,&nbsp;Eduardo A Novais,&nbsp;Ricardo L L Guerra","doi":"10.3205/oc000222","DOIUrl":"https://doi.org/10.3205/oc000222","url":null,"abstract":"The concept of retinal autofluorescence (AF) came to light in the 1970s when an autofluorescent signal of optic nerve head drusen (ONHD) was noted prior to the injection of fluorescein dye [1]. Nowadays, several devices offer distinct methods for acquiring short-wave fundus autofluorescence (SW-FAF) images, all of them being clinically useful in assessing the presence of lipofuscin, a naturally occurring ocular fluorophor which reflects the general health of the photoreceptor and retinal pigment epithelium (RPE). Each device provides a different image acquisition method; thus, discrepancies exist in the images obtained. For example, fundus cameras feature a high-energy white flash that streams through a wideband excitation filter and a series of mirrors and apertures to obtain images. On the other hand, confocal scanning laser ophthalmoscope (cSLO) emits a single wavelength, which will only excite fluorophores that absorb light with a peak excitation near that specific wavelength [2]. Broad line fundus image (BLFI) technique is a hybrid of both cSLO and traditional fundus photography. By utilizing line scanning illuminationwith light-emitting diodes (LEDs) and an aperture confocal to the illumination, this system illuminates and detects retinal images in two wavelength ranges: fundus autofluorescence (FAF)-Blue (435–500 nm) and FAF-Green (500–585 nm) [3]. Both are categorized as short-wavelength, but it is well known that green light can reach deeper layers of the retina, being absorbed less by the luteal pigments of themacula, and allowing a better definition of lesions in the underlying RPE. ONHD are a form of calcific degeneration in some of the axons of the optic nerve that may give a swollen-looking appearance, and are usually formed early in life. ONHD are diagnosed with fundoscopic examination, but some casesmay require B-scan ultrasonography, AF, and optical coherence tomography (OCT) to confirm the lesion [4]. The features of ONHD in FAF imaging are well described in many previous publications [4], [5]. Yan et al. [4] recently described the peculiarities of ONHD in FAF-Blue and -Green by using a cSLO system from two different devices. Despite a considerable amount of meaningful information, we were unable to find a description of FAF imaging in ONHD using BLFI technology in the literature. We have recently observed a noticeable disparity in the","PeriodicalId":73178,"journal":{"name":"GMS ophthalmology cases","volume":"13 ","pages":"Doc14"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10413383/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10000996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Successful management of recalcitrant fungal keratitis with topical caspofungin. 外用卡泊霉素成功治疗顽固性真菌性角膜炎。
Pub Date : 2022-07-18 eCollection Date: 2022-01-01 DOI: 10.3205/oc000206
Siddhi Goel, Arpit Sharma, Rajesh Sinha

Objective: To report a case of recalcitrant fungal keratitis successfully managed with topical caspofungin acetate in North India.

Methods: Case report and literature review.

Results: An 18-year-old male patient presented with complaints of redness, watering, pain and diminution of vision in the right eye and was referred to our centre as a case of corneal ulcer. The patient was examined and found to have a near total epithelial defect, with corneal infiltrates approximately 8x8 mm. A provisional diagnosis of polymicrobial keratitis was made based on corneal scraping suggestive of S tap h ylococcus aureus and confocal scan revealing fungal hyphae. The patient failed to respond to topical voriconazole 1%, natamycin 5% and moxifloxacin hydrochloride 0.5% with oral voriconazole. In view of the poor response to these drugs, the patient was subsequently administered topical caspofungin 0.5% in place of natamycin and continued on topical and oral voriconazole, in addition to topical moxifloxacin and cycloplegics, which finally led to healing with minimal scarring. The patient attained a best corrected visual acuity (BCVA) of 6/12.

Conclusion: Topical caspofungin may be used as a useful and effective alternative in cases of recalcitrant fungal keratitis. It may result in healing with minimal scarring.

目的:报告一例顽固性真菌性角膜炎在印度北部成功治疗。方法:病例报告和文献复习。结果:一名18岁的男性患者以右眼发红、流泪、疼痛和视力下降为主诉,作为角膜溃疡病例被转介到我中心。患者接受检查后发现几乎全上皮缺损,角膜浸润约8x8mm。基于提示金黄色葡萄球菌的角膜刮痧和共聚焦扫描显示真菌菌丝,初步诊断为多微生物角膜炎。患者外用1%伏立康唑、5%纳他霉素、0.5%盐酸莫西沙星口服伏立康唑无效。鉴于对这些药物的不良反应,患者随后被局部使用0.5%的卡泊芬净代替纳他霉素,并继续局部和口服伏立康唑,以及局部使用莫西沙星和单眼麻痹,最终导致瘢痕最小的愈合。患者的最佳矫正视力(BCVA)为6/12。结论:局部应用卡泊真菌素治疗难治性真菌性角膜炎是一种有效的治疗方法。它可能会导致愈合和最小的疤痕。
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引用次数: 0
Combined central retinal artery and vein occlusion following trabeculectomy. 小梁切除术后视网膜中央动静脉联合闭塞。
Pub Date : 2022-06-28 eCollection Date: 2022-01-01 DOI: 10.3205/oc000205
Albert John Bromeo, Sweet Jorlene Lerit, Patricia Grulla-Quilendrino, George Michael Sosuan, Edgar Leuenberger

Retinal vascular events may occur as rare complications of glaucoma procedures due to various factors, including exacerbation of ischemia in patients with pre-existing vascular comorbidities, toxic effect of mitomycin-C, and decompression retinopathy. We present the case of a 47-year-old hypertensive male who underwent trabeculectomy for advanced glaucoma in his right eye. At 3 weeks postoperatively, he presented with a drop in visual acuity to light perception with a spike in intraocular pressure. On examination, there was increased bleb vascularity as well as rubeosis. Fundoscopy revealed findings consistent with both central retinal artery occlusion and central retinal vein occlusion. Combined central retinal artery and vein occlusion is a rare retinal vascular condition. Neovascular glaucoma can occur as a sequelae of the ischemic process in the retina. Despite treatment, there is a poor visual prognosis, with the affected eye usually becoming blind from optic atrophy and neovascularization.

由于多种因素,视网膜血管事件可能作为青光眼手术的罕见并发症发生,包括先前存在血管合并症的患者缺血加剧,丝裂霉素c的毒性作用和减压性视网膜病变。我们提出的情况下,一个47岁的高血压男性谁接受小梁切除术晚期青光眼在他的右眼。术后3周,患者表现为对光的视敏度下降,眼压升高。检查时,有增加的水泡血管和红斑。眼底镜检查结果与视网膜中央动脉和视网膜中央静脉阻塞一致。视网膜中央动静脉合并闭塞是一种罕见的视网膜血管疾病。新生血管性青光眼可作为视网膜缺血过程的后遗症发生。尽管有治疗,但视力预后很差,受影响的眼睛通常因视神经萎缩和新生血管而失明。
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引用次数: 1
Unusual extraconal orbital location of a cavernous hemangioma. 海绵状血管瘤的异常眶外位置。
Pub Date : 2022-06-10 eCollection Date: 2022-01-01 DOI: 10.3205/oc000204
Gabriela Pacheco Callirgos, Francisco Javier Valentín Bravo, Pablo Panadero Meseguer, Víctor Manuel Asensio Sánchez

Cavernous hemangioma is the most common benign orbital and vascular tumor in adults. It is mostly located intraconally. Nevertheless, when the location is extraconal, the displacement of the globe is opposite the tumor's position. We describe an unusual presentation of this tumor in a 75-year-old female. The only symptom was the presence of epiphora. In the clinical examination, a mass was palpated on the lower orbital rim of the right eye. The magnetic resonance imaging (MRI) showed a well-circumscribed ovoid mass with a strong T2 hyperintensity and progressive contrast filling in T1. Excisional biopsy was performed, which confirmed the diagnosis of cavernous hemangioma. At five months of follow-up, there was no evidence of new symptoms.

海绵状血管瘤是成人最常见的眼眶及血管良性肿瘤。它主要位于体内。然而,当位置在外时,球体的位移与肿瘤的位置相反。我们描述一个不寻常的表现,这个肿瘤在一个75岁的女性。唯一的症状是出现了眼红。在临床检查中,在右眼下眶缘触诊到肿块。磁共振成像(MRI)显示一个边界清晰的卵形肿块,T2高强度,T1进行性造影剂充盈。行切除活检,确诊为海绵状血管瘤。在5个月的随访中,没有出现新的症状。
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引用次数: 0
期刊
GMS ophthalmology cases
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