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An analytical framework for enhancing brain signal classification through hybrid filtering and dimensionality reduction 一种通过混合滤波和降维增强脑信号分类的分析框架
Pub Date : 2025-12-01 Epub Date: 2025-11-09 DOI: 10.1016/j.health.2025.100435
Rajani Rai B , Karunakara Rai B , Mamatha A S , Nikshitha
Accurate classification of focal and non-focal epilepsy is a critical healthcare analytics challenge that requires robust data preprocessing and feature optimization. This work develops an integrated analytics framework that combines hybrid filtering with hybrid dimensionality reduction to improve both signal quality and predictive performance. A multi-criteria ranking strategy based on the Technique for Order Preference by Similarity to Ideal Solution (TOPSIS) is employed, incorporating conventional signal measures alongside distance and divergence metrics to identify optimal preprocessing pipelines. Statistical validation is performed using the Friedman test with Nemenyi post-hoc analysis to establish the significance of competing filter–dimensionality reduction combinations. The validated framework is benchmarked across conventional, hybrid, and deep learning classifiers, with the most effective configuration—Butterworth.
Wavelet Packet Decomposition (BW + WPD) filtering followed by Principal Component Analysis–Linear Discriminant Analysis (PCA + LDA)—achieving 95.63% accuracy using an Adaboost classifier on the Bern–Barcelona dataset. Evaluation on the independent Bonn dataset confirms robustness and cross-subject generalizability. These findings demonstrate the value of a multi-metric, statistically validated analytics strategy for reliable epilepsy detection, with potential applicability to broader healthcare signal classification tasks.
准确分类局灶性和非局灶性癫痫是一个关键的医疗保健分析挑战,需要稳健的数据预处理和特征优化。这项工作开发了一个集成的分析框架,将混合滤波与混合降维相结合,以提高信号质量和预测性能。采用基于TOPSIS (Order Preference by Similarity to Ideal Solution)的多准则排序策略,结合传统的信号度量以及距离和散度度量来确定最优的预处理管道。统计验证使用Friedman检验和Nemenyi事后分析来确定竞争过滤器降维组合的显著性。经过验证的框架在传统、混合和深度学习分类器中进行基准测试,并使用最有效的配置- butterworth。小波包分解(BW + WPD)滤波,然后是主成分分析-线性判别分析(PCA + LDA),在Bern-Barcelona数据集上使用Adaboost分类器实现95.63%的准确率。对独立波恩数据集的评估证实了鲁棒性和跨主题泛化性。这些发现证明了一种多度量的、经过统计验证的分析策略对可靠的癫痫检测的价值,具有更广泛的医疗信号分类任务的潜在适用性。
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引用次数: 0
A comparative analysis of generalized additive models for obesity risk prediction 肥胖风险预测的广义加性模型的比较分析
Pub Date : 2025-12-01 Epub Date: 2025-08-27 DOI: 10.1016/j.health.2025.100410
Olushina Olawale Awe , Olawale Abiodun Olaniyan , Ayorinde Emmanuel Olatunde , Ronel SewPaul , Natisha Dukhi
Obesity is a growing global health crisis, and traditional regression models often fail to capture the complex relationships between risk factors, limiting predictive accuracy and hindering effective public health interventions. Conventional methods overlook non-linear associations and interaction effects across demographic, socioeconomic, and behavioral predictors, which are particularly important in diverse populations with varying obesity determinants. To address these limitations, we applied Generalized Additive Models for Location, Scale, and Shape (GAMLSS) to analyze obesity predictors in a nationally representative adolescent sample (N = 671). Our framework included comprehensive variable selection across demographic, socioeconomic, behavioral, and clinical domains, comparison with three alternative regression models, and validation using the Generalized Akaike Information Criterion (GAIC). The binomial stepwise GAMLSS model demonstrated superior performance (GAIC = 624.98). Key findings included strong geographic variation, significant gender disparity, a socioeconomic gradient, and important behavioral predictors such as weight gain attempts. The GAMLSS framework improves obesity risk prediction by modeling complex relationships often missed by traditional methods, offering targeted intervention strategies based on geographic, gender, and socioeconomic factors, and challenging assumptions about dietary influences.
肥胖是一个日益严重的全球健康危机,传统的回归模型往往无法捕捉风险因素之间的复杂关系,从而限制了预测的准确性,阻碍了有效的公共卫生干预。传统方法忽略了人口统计、社会经济和行为预测因素之间的非线性关联和相互作用效应,这在具有不同肥胖决定因素的不同人群中尤为重要。为了解决这些局限性,我们应用了位置、规模和形状的广义加性模型(GAMLSS)来分析全国代表性青少年样本(N = 671)的肥胖预测因子。我们的框架包括人口统计学、社会经济、行为和临床领域的综合变量选择,与三种替代回归模型的比较,并使用广义赤池信息标准(gac)进行验证。二项逐步GAMLSS模型表现出较好的性能(GAIC = 624.98)。主要发现包括强烈的地理差异、显著的性别差异、社会经济梯度和重要的行为预测因素,如体重增加的尝试。GAMLSS框架通过建模传统方法经常忽略的复杂关系来改进肥胖风险预测,提供基于地理、性别和社会经济因素的有针对性的干预策略,并挑战有关饮食影响的假设。
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引用次数: 0
An analytical review of biosensor-based chronic pain quantification in healthcare 医疗保健中基于生物传感器的慢性疼痛量化分析综述
Pub Date : 2025-12-01 Epub Date: 2025-09-15 DOI: 10.1016/j.health.2025.100419
Aarthi Kannan , Daniel West , Dinesh Kumbhare , Wei-Ting Ting , Md. Younus Ali , Hameem I. Kawsar , Gurmit Singh , Harsha Shanthanna , Eleni Hapidou , Matiar M.R. Howlader
Current clinical methods for chronic pain assessment lack objective, quantitative measures, creating a critical gap in diagnostic accuracy. This review investigates the relationship between chronic pain and key biomarkers detectable in body fluids, such as glutamate, interleukin-6, nitric oxide, and quinolinic acid. We first discuss the biological mechanisms underlying chronic pain and evaluate the relevance of these biomarkers. The review then focuses on recent advancements in non-enzymatic electrochemical biosensors used to monitor these biomarkers. For each sensor, we summarize performance metrics including sensitivity, detection limits, and linear range, while highlighting the analytical methodologies used to establish correlations between biomarker levels and pain intensity. Our findings demonstrate that quantitative analysis of biomarker fluctuations can enhance chronic pain monitoring. The integration of sensor-based biomarker analytics with clinical workflows may offer a path toward personalized treatment plans and improved decision-making in healthcare supply chains. This review emphasizes the need for continued development of high-precision biosensors as analytical tools for translating physiological signals into clinically actionable pain metrics.
目前的临床方法慢性疼痛评估缺乏客观,定量的措施,造成诊断准确性的关键差距。本文综述了慢性疼痛与体液中可检测的关键生物标志物,如谷氨酸、白细胞介素-6、一氧化氮和喹啉酸之间的关系。我们首先讨论了慢性疼痛的生物学机制,并评估了这些生物标志物的相关性。然后综述了用于监测这些生物标志物的非酶电化学生物传感器的最新进展。对于每个传感器,我们总结了性能指标,包括灵敏度、检测限和线性范围,同时强调了用于建立生物标志物水平和疼痛强度之间相关性的分析方法。我们的研究结果表明,生物标志物波动的定量分析可以加强慢性疼痛监测。基于传感器的生物标志物分析与临床工作流程的集成可能为个性化治疗计划和改善医疗保健供应链的决策提供途径。这篇综述强调需要继续发展高精度的生物传感器作为分析工具,将生理信号转化为临床可操作的疼痛指标。
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引用次数: 0
An analytics-driven review of U-Net for medical image segmentation U-Net用于医学图像分割的分析驱动综述
Pub Date : 2025-12-01 Epub Date: 2025-09-20 DOI: 10.1016/j.health.2025.100416
Fnu Neha , Deepshikha Bhati , Deepak Kumar Shukla , Sonavi Makarand Dalvi , Nikolaos Mantzou , Safa Shubbar
Medical imaging (MI) plays a vital role in healthcare by providing detailed insights into anatomical structures and pathological conditions, supporting accurate diagnosis and treatment planning. Noninvasive modalities, such as X-ray, magnetic resonance imaging (MRI), computed tomography (CT), and ultrasound (US), produce high-resolution images of internal organs and tissues. The effective interpretation of these images relies on the precise segmentation of the regions of interest (ROI), including organs and lesions. Traditional methods based on manual feature extraction are time-consuming, inconsistent, and not scalable. This review explores recent advances in artificial intelligence (AI)-driven segmentation, focusing on Convolutional Neural Network (CNN) architectures, particularly the U-Net family and its variants—U-Net++, and U-Net 3+. These models enable automated, pixel-wise classification across modalities and have improved segmentation accuracy and efficiency. The review outlines the evolution of U-Net architectures, their clinical integration, and offers a modality-wise comparison. It also addresses challenges such as data heterogeneity, limited generalizability, and model interpretability, proposing solutions including attention mechanisms and Transformer-based designs. Emphasizing clinical applicability, this work bridges the gap between algorithmic development and real-world implementation.
医学成像(MI)通过提供解剖结构和病理状况的详细信息,支持准确的诊断和治疗计划,在医疗保健中发挥着至关重要的作用。无创模式,如x射线,磁共振成像(MRI),计算机断层扫描(CT)和超声(US),产生内部器官和组织的高分辨率图像。这些图像的有效解释依赖于对感兴趣区域(ROI)的精确分割,包括器官和病变。传统的基于人工特征提取的方法耗时长、不一致且不可扩展。本文探讨了人工智能(AI)驱动的分段技术的最新进展,重点关注卷积神经网络(CNN)架构,特别是U-Net家族及其变体——U-Net++和U-Net 3+。这些模型支持跨模态的自动、逐像素分类,并提高了分割的准确性和效率。这篇综述概述了U-Net体系结构的演变,它们的临床整合,并提供了一个模式明智的比较。它还解决了诸如数据异构、有限的通用性和模型可解释性等挑战,提出了包括注意力机制和基于转换器的设计在内的解决方案。强调临床适用性,这项工作弥合了算法开发和现实世界实现之间的差距。
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引用次数: 0
A data-driven multicriteria decision model for healthcare workforce retention strategies 医疗保健人力保留策略的数据驱动多标准决策模型
Pub Date : 2025-12-01 Epub Date: 2025-06-13 DOI: 10.1016/j.health.2025.100403
Debora Di Caprio , Sofia Sironi , Fan-Yun Lan , Ramin Rostamkhani
The retention of nurses and physicians in Hospitals is a global problem affecting the healthcare system worldwide. This study focuses on the healthcare workforce retention problem considering the current situation in Taiwan. Healthcare staff in Taiwan are undergoing a critical phase, with an increasing number of experienced workers leaving their job to go to work for private organizations or as freelancers. We develop a data-driven four-phase methodology based on the design of a satisfaction index that allows to rank different groups of employees against a given set of criteria. First, criteria are identified and clustered to describe different job dimensions (phase 1). Hence, subjective evaluations of the criteria are collected from healthcare workers while experts provide pairwise comparisons among them (phase 2). An adjusted analytic hierarchy process (AHP) is used to weight the job dimensions and the criteria within each job dimension (phase 3). Finally, the satisfaction index is formalized and computed for different groups of employees (phase 4). The methodology has been implemented with data collected from healthcare workers employed in three healthcare institutions in Northern Taiwan. The proposed index represents a novel decision support tool for managers and policy makers in designing intervention strategies able to address different needs of different groups of employees. Besides, it allows for innovative applications to quality management (QM) by extending the standard QM approach to hospitals and healthcare centers far beyond the common focus on patients' satisfaction. Finally, the mathematical formulation of the index is very flexible and allows for applications to any employment sector through a variety of analyses based on different categorizations of the workers.
护士和医生在医院的保留是一个全球性的问题,影响全球医疗保健系统。本研究针对目前台湾医疗保健人力保留问题进行研究。台湾的医护人员正处于一个关键阶段,越来越多有经验的医护人员离开工作岗位,去私人机构工作或成为自由职业者。我们开发了一种基于满意度指数设计的数据驱动的四阶段方法,该指数允许根据给定的一组标准对不同组的员工进行排名。首先,确定标准并将其聚类以描述不同的工作维度(阶段1)。因此,从卫生保健工作者那里收集对标准的主观评价,而专家在他们之间进行两两比较(阶段2)。采用调整后的层次分析法(AHP)对工作维度和每个工作维度内的标准进行加权(阶段3)。最后,对不同员工群体的满意度指数进行形式化和计算(阶段4)。本研究以台湾北部三所医疗机构的医护人员为研究对象。该指标为管理者和政策制定者设计干预策略提供了一种新的决策支持工具,能够满足不同员工群体的不同需求。此外,通过将标准质量管理方法扩展到医院和医疗保健中心,它允许质量管理(QM)的创新应用程序,远远超出了对患者满意度的通常关注。最后,该指数的数学公式非常灵活,并允许通过基于不同类别的工人的各种分析应用于任何就业部门。
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引用次数: 0
An analytics framework for healthcare expenditure forecasting with machine learning 基于机器学习的医疗保健支出预测分析框架
Pub Date : 2025-12-01 Epub Date: 2025-10-28 DOI: 10.1016/j.health.2025.100428
John Wang , Shubin Xu , Yawei Wang , Houda EL Bouhissi
The United States healthcare system relies heavily on Medicaid, which serves nearly 80 million people and accounts for a substantial share of both state and federal budgets. This study employs a range of forecasting methods, including ARIMA, Holt's linear trend, polynomial regressions (degree 2 and 4), Prophet, and piecewise linear regression, as well as machine learning models such as random forest, gradient boosting, and support vector regression, to analyze the growth of Medicaid expenditures. Using data from 1966 to 2024, the analysis identifies historical patterns and evaluates model performance with Root Mean Squared Error (RMSE) and related metrics to project costs through 2035. The results show that the autoregressive model with integrated moving average and Prophet generate the most accurate baseline forecasts, suggesting that Medicaid expenditures are likely to exceed one trillion dollars within the next 15 years. Although the machine learning models produced somewhat lower estimates, they revealed complex relationships between policy variables and expenditure behavior, making them useful for building alternative forecasting scenarios. The discussion emphasizes the policy relevance of these findings, particularly in relation to budget sustainability and healthcare equity, and highlights the importance of employing multiple forecasting approaches. Overall, the study demonstrates the value of decision analytics in healthcare forecasting by highlighting the need for accurate predictions, flexible models, and interpretable outcomes. It provides evidence-based tools to anticipate Medicaid's financial challenges and support the development of sustainable healthcare strategies for the years ahead.
美国医疗保健系统严重依赖医疗补助计划,该计划为近8000万人提供服务,占州和联邦预算的很大一部分。本研究采用ARIMA、Holt线性趋势、多项式回归(2度和4度)、Prophet和分段线性回归等预测方法,以及随机森林、梯度增强和支持向量回归等机器学习模型,对医疗补助支出的增长进行了分析。使用1966年至2024年的数据,分析确定了历史模式,并使用均方根误差(RMSE)和2035年项目成本的相关指标评估了模型的性能。结果表明,综合移动平均线和Prophet的自回归模型产生了最准确的基线预测,表明医疗补助支出可能在未来15年内超过1万亿美元。尽管机器学习模型产生的估计值略低,但它们揭示了政策变量和支出行为之间的复杂关系,这使得它们对构建替代预测场景很有用。讨论强调了这些发现的政策相关性,特别是在预算可持续性和医疗公平方面,并强调了采用多种预测方法的重要性。总体而言,该研究通过强调对准确预测、灵活模型和可解释结果的需求,展示了决策分析在医疗保健预测中的价值。它提供了基于证据的工具来预测医疗补助计划的财务挑战,并支持未来几年可持续医疗保健战略的发展。
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引用次数: 0
A machine learning framework for predicting healthcare utilization and risk factors 用于预测医疗保健利用和风险因素的机器学习框架
Pub Date : 2025-12-01 Epub Date: 2025-08-19 DOI: 10.1016/j.health.2025.100411
Yead Rahman , Prerna Dua
Medicaid data, with its vast scale and heterogeneity, presents significant challenges in predictive modeling and healthcare analytics. This study analyzes over 6.3 million records from the Louisiana Department of Health (LDH) to identify the most effective machine learning models for predicting clinical service utilization, COVID-19 infections, and tobacco use. A rigorous preprocessing pipeline ensured data integrity, while exploratory data analysis (EDA) guided feature selection, ultimately retaining 20 key variables to capture complex interactions. Seven supervised models, i.e., logistic regression, extreme gradient boosting (XGBoost), adaptive boosting (AdaBoost), random forest, decision tree, artificial neural networks (ANN), and naïve bayes, were evaluated based on predictive performance, computational efficiency, and feature importance. While ensemble methods such as XGBoost and random forest achieved superior accuracy, their high computational demands highlight the trade-off between performance and efficiency in large-scale healthcare analytics. Simpler models like naïve bayes and decision trees were computationally efficient but less accurate. Key predictors included hospital stay duration for healthcare service utilization, tobacco use for COVID-19 risk, and chronic obstructive pulmonary disease (COPD) for tobacco use. These findings emphasize the impact of comorbidities and demographics on healthcare utilization, offering data-driven insights for healthcare practitioners and policymakers to enhance patient care, optimize costs, and refine policy decisions.
医疗补助数据由于其庞大的规模和异质性,在预测建模和医疗保健分析方面提出了重大挑战。这项研究分析了路易斯安那州卫生部(LDH)的630多万份记录,以确定预测临床服务利用、COVID-19感染和烟草使用的最有效的机器学习模型。严格的预处理流程确保了数据的完整性,而探索性数据分析(EDA)指导了特征选择,最终保留了20个关键变量来捕获复杂的交互。基于预测性能、计算效率和特征重要性评估了7种监督模型,即逻辑回归、极端梯度增强(XGBoost)、自适应增强(AdaBoost)、随机森林、决策树、人工神经网络(ANN)和naïve贝叶斯。虽然集成方法(如XGBoost和随机森林)实现了卓越的准确性,但它们的高计算需求突出了大规模医疗保健分析中性能和效率之间的权衡。更简单的模型,如naïve贝叶斯和决策树,计算效率高,但准确性较低。主要预测因素包括医疗服务使用的住院时间、COVID-19风险的烟草使用以及烟草使用的慢性阻塞性肺疾病(COPD)。这些发现强调了合并症和人口统计学对医疗保健利用的影响,为医疗保健从业者和政策制定者提供了数据驱动的见解,以加强患者护理,优化成本,并完善政策决策。
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引用次数: 0
EAGLE-Net: A hierarchical neural network for detecting anatomical landmarks in upper gastrointestinal endoscopy for clinical diagnosis EAGLE-Net:一种用于检测上消化道内镜解剖标志的分层神经网络,用于临床诊断
Pub Date : 2025-12-01 Epub Date: 2025-09-20 DOI: 10.1016/j.health.2025.100420
Thi Thu Huong Nguyen , Van Duy Truong , Xuan Huy Manh , Thanh Tung Nguyen , Hang Viet Dao , Hai Vu
This study proposes a hierarchical network architecture, named EAGLE-Net, for identifying anatomical landmarks in the upper gastrointestinal (GI) tract endoscopic videos. Unlike conventional techniques, which label anatomical landmarks for static endoscopic images, the proposed method aims to classify landmarks from videos of the upper GI tract. Video streams often suffer from many noises and contaminated objects, which requires a new approach to tackle this issue. The proposed technique utilizes hierarchical network architecture, which consists of two stages: endoscopic image quality assessment and anatomical landmark classification. In the first stage, high-quality frames are preserved from GI tract videos. These frames are then used to identify a specific location among ten anatomical landmarks. The proposed method increases the coherence between the hierarchical data levels. It integrates an attention module to strengthen feature connections and utilizes a new hierarchical cross-entropy loss function to optimize model performance. The experimental results demonstrated that the proposed system achieves a high accuracy of 93% on average in both classification stages. In clinical experiments, anatomical landmarks are automatically denoted to help physicians monitor the endoscopy process. In addition, the proposed method demonstrates a potential solution for the deployment of a computer-aided diagnostic application for the detection and treatment of upper GI tract lesions.
本研究提出了一种名为EAGLE-Net的分层网络架构,用于识别上消化道内镜视频中的解剖标志。与传统的标记静态内窥镜图像解剖地标的技术不同,该方法旨在从上消化道视频中对地标进行分类。视频流经常受到许多噪声和污染物体的影响,这需要一种新的方法来解决这个问题。该方法采用分层网络结构,包括内镜图像质量评估和解剖地标分类两个阶段。在第一阶段,从胃肠道视频中保留高质量的帧。然后使用这些框架在十个解剖标志中识别特定位置。该方法提高了分层数据层之间的一致性。它集成了一个关注模块来加强特征连接,并利用新的分层交叉熵损失函数来优化模型性能。实验结果表明,该系统在两个分类阶段的平均准确率均达到93%以上。在临床实验中,解剖标志被自动标记,以帮助医生监测内镜检查过程。此外,所提出的方法为计算机辅助诊断应用程序的部署提供了一种潜在的解决方案,用于检测和治疗上消化道病变。
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引用次数: 0
A multi-agent reinforcement learning framework for public health decision analysis 公共卫生决策分析的多智能体强化学习框架
Pub Date : 2025-12-01 Epub Date: 2025-11-20 DOI: 10.1016/j.health.2025.100436
Dinesh Sharma , Ankit Shah , Chaitra Gopalappa
Human immunodeficiency virus (HIV) is a major public health concern in the United States (U.S.), with about 1.2 million people living with it and about 35,000 newly infected each year. There are considerable geographical disparities in HIV burden and care access across the U.S. The ’Ending the HIV Epidemic (EHE)’ initiative by the U.S. Department of Health and Human Services aims to reduce new infections by 90% by 2030, by improving coverage of diagnoses, treatment, and prevention interventions and prioritizing jurisdictions with high HIV prevalence. One of the approaches towards achieving this objective includes developing intelligent decision-support systems that can help optimize resource allocation and intervention strategies. Existing decision analytic models either focus on individual cities or aggregate national data, failing to capture jurisdictional interactions critical for optimizing intervention strategies. To address this, we propose a multi-agent reinforcement learning (MARL) framework that enables jurisdiction-specific decision-making while accounting for cross-jurisdictional epidemiological interactions. Our framework functions as an intelligent resource optimization system, helping policymakers strategically allocate interventions based on dynamic, data-driven insights. Experimental results across jurisdictions in California and Florida demonstrate that MARL-driven policies outperform traditional single-agent reinforcement learning approaches by reducing new infections under fixed budget constraints. Our study highlights the importance of incorporating jurisdictional dependencies in decision-making frameworks for large-scale public initiatives. By integrating multi-agent intelligent systems, decision analytics, and reinforcement learning, this study advances expert systems for government resource planning and public health management, offering a scalable framework for broader applications in healthcare policy and epidemic management.
人类免疫缺陷病毒(艾滋病毒)是美国一个主要的公共卫生问题,约有120万人感染艾滋病毒,每年约有3.5万名新感染者。美国各地在艾滋病毒负担和护理机会方面存在相当大的地域差异。美国卫生与公众服务部的“终结艾滋病毒流行(EHE)”倡议旨在通过提高诊断、治疗和预防干预的覆盖率,并优先考虑艾滋病毒高流行的司法管辖区,到2030年将新感染人数减少90%。实现这一目标的方法之一包括开发智能决策支持系统,以帮助优化资源分配和干预策略。现有的决策分析模型要么关注单个城市,要么关注汇总的国家数据,未能捕捉到对优化干预策略至关重要的管辖权相互作用。为了解决这个问题,我们提出了一个多智能体强化学习(MARL)框架,该框架可以在考虑跨司法管辖区流行病学相互作用的同时,实现特定司法管辖区的决策。我们的框架作为一个智能资源优化系统,帮助决策者根据动态的、数据驱动的见解战略性地分配干预措施。加州和佛罗里达州的实验结果表明,在固定预算约束下,marl驱动的政策通过减少新感染,优于传统的单智能体强化学习方法。我们的研究强调了在大规模公共倡议的决策框架中纳入司法依赖关系的重要性。通过整合多智能体智能系统、决策分析和强化学习,本研究为政府资源规划和公共卫生管理提供了专家系统,为医疗政策和流行病管理提供了一个可扩展的框架。
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引用次数: 0
A deep learning framework for automated breast cancer diagnosis using intelligent segmentation and classification 一种使用智能分割和分类的自动化乳腺癌诊断的深度学习框架
Pub Date : 2025-12-01 Epub Date: 2025-08-30 DOI: 10.1016/j.health.2025.100414
Ahed Abugabah
Breast cancer is the most commonly diagnosed cancer among women worldwide, accounting for a significant proportion of new cases. Deep learning (DL) has emerged as a powerful tool for the detection and diagnosis of breast cancer, particularly through the analysis of histological images, a critical component of automated diagnostic systems that directly impact patient management. The BreakHis dataset and the Wisconsin Breast Cancer Database (WBCD) are widely used publicly available resources for deep learning–based analyses of breast cancer histological images in cross-disciplinary healthcare research. A computer-assisted approach employs colour normalisation to reduce the effects of the differences in the distribution of breast histopathology images. In this paper, breast tumour areas of interest are segmented utilising Attention-Guided Deep Atrous-Residual U-Net at the segmentation stage. Subsequently, patches are processed to form feature vectors VGG19 and ResNet50 for the extraction of deep features from the patches. Also, to fine-tune these models even further, the breast cancer datasets are employed, and Levy Flight-based Red Fox Optimisation is used to extract features from the pre-trained models without further training. The Efficient Capsule Network is used to improve the feature representation and classification capabilities. AGDATUNet-LFRFO-ECN, which was suggested in the study, performed better than other models when tested on the WBCD dataset, with a sensitivity of 99.17 %, specificity of 99.08 %, and accuracy of 99.23 %. What's more, the AGDATUNet-LFRFO-ECN outperformed the available models on BreakHis with a sensitivity of 99.81 %, a specificity of 99.79 %, and an accuracy of 99.82 %, which are the state-of-the-art.
乳腺癌是全世界妇女中最常见的癌症,占新病例的很大比例。深度学习(DL)已经成为乳腺癌检测和诊断的强大工具,特别是通过对组织学图像的分析,这是直接影响患者管理的自动化诊断系统的关键组成部分。BreakHis数据集和威斯康星乳腺癌数据库(WBCD)是广泛使用的公共资源,用于跨学科医疗保健研究中基于深度学习的乳腺癌组织学图像分析。计算机辅助方法采用颜色归一化来减少乳腺组织病理学图像分布差异的影响。在本文中,在分割阶段利用注意力引导的深度阿鲁斯-残余U-Net对感兴趣的乳腺肿瘤区域进行分割。然后对patch进行处理,形成特征向量VGG19和ResNet50,从patch中提取深度特征。此外,为了进一步微调这些模型,我们使用了乳腺癌数据集,并使用Levy Flight-based Red Fox Optimisation从预先训练的模型中提取特征,而无需进一步训练。高效胶囊网络用于提高特征表示和分类能力。研究中提出的AGDATUNet-LFRFO-ECN模型在WBCD数据集上的测试结果优于其他模型,灵敏度为99.17%,特异性为99.08%,准确率为99.23%。此外,AGDATUNet-LFRFO-ECN的灵敏度为99.81%,特异性为99.79%,准确率为99.82%,优于BreakHis上现有的模型,达到了最先进的水平。
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引用次数: 0
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Healthcare analytics (New York, N.Y.)
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