This study introduces the physical principles and safety evaluation of recombinant bovine lactoferrin (fusion factor) as an innovative biomaterial. Fusion factor is a recombinant lactoferrin expressed by fusing lactoferrin, which has natural biological defense function, with other peptide segments through sequence optimization. It is named fusion factor. Its molecular weight is about 36kDa, which is much greater than the 1kDa molecular weight limit of macromolecular transdermal absorption, so it is not absorbed when used externally on the epithelial mucosa. The lactoferrin based biological defense functional peptide segment in the fusion factor can neutralize the virus by binding to viral protein nucleic acid through the physical action of charge adsorption, and can also compete with cell receptors to inhibit virus infection in cells. The molar ratio of the transmembrane peptide (Pep-1) fragment to the carrier protein is 1:1, so only the transport protein is anchored to the cell surface, forming a physical isolation protein protective wall against viruses and bacteria, without penetrating the cell or damaging the cell membrane. The fusion factor and its derived vaginal bacteria blocking gel have no significant toxicity, sensitization, anaphylaxis or delayed hypersensitivity in vitro cell experiments, in vivo animal experiments and clinical observation tests, and have no side effects with highly safety.
{"title":"Safety Evaluation of Recombinant Bovine Lactoferrin as a Novel Biomaterial","authors":"Jiamiao Sun, Sumin Zhang, Yong Wang, Jinchi Wei, Yonghui Teng, Binghua Quan, Xiaoming Pang, Honghong Deng, Chiming Wei","doi":"10.11648/j.ijbecs.20241001.11","DOIUrl":"https://doi.org/10.11648/j.ijbecs.20241001.11","url":null,"abstract":"This study introduces the physical principles and safety evaluation of recombinant bovine lactoferrin (fusion factor) as an innovative biomaterial. Fusion factor is a recombinant lactoferrin expressed by fusing lactoferrin, which has natural biological defense function, with other peptide segments through sequence optimization. It is named fusion factor. Its molecular weight is about 36kDa, which is much greater than the 1kDa molecular weight limit of macromolecular transdermal absorption, so it is not absorbed when used externally on the epithelial mucosa. The lactoferrin based biological defense functional peptide segment in the fusion factor can neutralize the virus by binding to viral protein nucleic acid through the physical action of charge adsorption, and can also compete with cell receptors to inhibit virus infection in cells. The molar ratio of the transmembrane peptide (Pep-1) fragment to the carrier protein is 1:1, so only the transport protein is anchored to the cell surface, forming a physical isolation protein protective wall against viruses and bacteria, without penetrating the cell or damaging the cell membrane. The fusion factor and its derived vaginal bacteria blocking gel have no significant toxicity, sensitization, anaphylaxis or delayed hypersensitivity in vitro cell experiments, in vivo animal experiments and clinical observation tests, and have no side effects with highly safety.\u0000","PeriodicalId":73426,"journal":{"name":"International journal of biomedical engineering and clinical science","volume":"11 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140261163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Determinants of Neonatal Outcomes for Preterm Infants Admitted to the Neonatal Intensive Care Unit at Ndola Teaching Hospital in Ndola District, Zambia","authors":"Nsululu Hyascinth Mbulo, Siwale Mwaba Chileshe, Kwaleyela Namukolo Concepta","doi":"10.11648/j.ijbecs.20230904.12","DOIUrl":"https://doi.org/10.11648/j.ijbecs.20230904.12","url":null,"abstract":"","PeriodicalId":73426,"journal":{"name":"International journal of biomedical engineering and clinical science","volume":"25 16","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138984157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-20DOI: 10.11648/j.ijbecs.20230903.14
D. Dzhuzha
{"title":"Predicative Meaning of Radioiodine Pharmacokinetics Indices for Evaluation of Radioablation Efficacy of Thyroid Residuum in Patients with Differentiated Thyroid Cancer","authors":"D. Dzhuzha","doi":"10.11648/j.ijbecs.20230903.14","DOIUrl":"https://doi.org/10.11648/j.ijbecs.20230903.14","url":null,"abstract":"","PeriodicalId":73426,"journal":{"name":"International journal of biomedical engineering and clinical science","volume":"259 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86717973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-13DOI: 10.11648/j.ijbecs.20230903.13
Huiyang Kong, Shuyi Wang, Hua Xing
{"title":"The Effectiveness of Three-Dimensional Planning and Augmented Reality Navigation-Assisted Total Hip Arthroplasty: A Systematic Review and Meta-Analysis","authors":"Huiyang Kong, Shuyi Wang, Hua Xing","doi":"10.11648/j.ijbecs.20230903.13","DOIUrl":"https://doi.org/10.11648/j.ijbecs.20230903.13","url":null,"abstract":"","PeriodicalId":73426,"journal":{"name":"International journal of biomedical engineering and clinical science","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81034359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-13DOI: 10.11648/j.ijbecs.20230903.12
Betelihem Yirdaw, Dessie Abera
{"title":"Epidemiology and Diagnostic Methods of Foot-and-Mouth Disease: A Review","authors":"Betelihem Yirdaw, Dessie Abera","doi":"10.11648/j.ijbecs.20230903.12","DOIUrl":"https://doi.org/10.11648/j.ijbecs.20230903.12","url":null,"abstract":"","PeriodicalId":73426,"journal":{"name":"International journal of biomedical engineering and clinical science","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80939924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-06DOI: 10.11648/j.ijbecs.20230903.11
Adebola Oluwabusayo Adetiloye, Farhana Alladin, Abida Naz, K. Ghosh, O. Badero, O. Adewuya, A. Poor
{"title":"Effect of Educational Intervention on Oxygen Therapy Knowledge and Prescription Practices in an Inpatient Community Hospital: A Quality Improvement Initiative","authors":"Adebola Oluwabusayo Adetiloye, Farhana Alladin, Abida Naz, K. Ghosh, O. Badero, O. Adewuya, A. Poor","doi":"10.11648/j.ijbecs.20230903.11","DOIUrl":"https://doi.org/10.11648/j.ijbecs.20230903.11","url":null,"abstract":"","PeriodicalId":73426,"journal":{"name":"International journal of biomedical engineering and clinical science","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87582192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-10DOI: 10.11648/j.ijbecs.20230902.11
Jean Pierre Omam Omam, André Hamadou, Antoine Kavaye Kandeda, J. Koubé, Djibrilla Mana Moussa, Brice Kevin Tchoupe Djoumsie, Mireille Delphine Minkoulou Ze, Roger Sébastien Ndjock, E. Ngo Bum
{"title":"The Decoction of <i>Cymbopogon citratus </i>(<i>Poaceae</i>) Exerts Anxiolytic and Antioxidant Effects<i> </i>in Mice on Stress Paradigm Tests","authors":"Jean Pierre Omam Omam, André Hamadou, Antoine Kavaye Kandeda, J. Koubé, Djibrilla Mana Moussa, Brice Kevin Tchoupe Djoumsie, Mireille Delphine Minkoulou Ze, Roger Sébastien Ndjock, E. Ngo Bum","doi":"10.11648/j.ijbecs.20230902.11","DOIUrl":"https://doi.org/10.11648/j.ijbecs.20230902.11","url":null,"abstract":"","PeriodicalId":73426,"journal":{"name":"International journal of biomedical engineering and clinical science","volume":"37 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86683007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-31DOI: 10.11648/j.ijbecs.20230901.12
Bouopda Tamo Sylvain Parfait, Mundene-Timothee Junior Lawrence
: Coronavirus disease 2019 (COVID-19) was declared by the World Health Organization (WHO) as a pandemic on March 11, 2020. Despite the development of anti-COVID-19 vaccine, the disease continues to kill thousands of people, mainly due to a lack of sufficient doses for all populations and to the prioritization of populations to be vaccinated. According to epidemiological data from April 06, 2022, the COVID-19 pandemic has already killed more than 6,184,299 people around the world with nearly 494,286,073confirmed cases. To date, no antiviral drug has been officially approved to fight this pandemic. Medical professionals and researchers all over the globe are in pursuit for the discovery therapies against this disease. One of the strategies is the use of medicinal plants. Indeed, plant extracts can inhibit viral growth and their effectiveness has been demonstrated on many viruses encountered in human pathology including SARS-CoV-1, poliovirus, varicella-zoster virus, HIV, human papillomavirus, HSV-1, HSV-2, influenza virus, cytomegalovirus and many others. Besides, it has been shown that plant extracts can regulate immune system and make the body able to prevent the establishment of viral infection or to fight against its deleterious effects. The exploration of plant extracts with anti-viral and immunostimulatory properties could be exploitable in the development of drug against COVID-19. This review promotes medicinal plant extracts as potential anti-COVID-19 drugs.
{"title":"Therapy Against COVID-19: Medicinal Plant Extracts Can Be a Solution","authors":"Bouopda Tamo Sylvain Parfait, Mundene-Timothee Junior Lawrence","doi":"10.11648/j.ijbecs.20230901.12","DOIUrl":"https://doi.org/10.11648/j.ijbecs.20230901.12","url":null,"abstract":": Coronavirus disease 2019 (COVID-19) was declared by the World Health Organization (WHO) as a pandemic on March 11, 2020. Despite the development of anti-COVID-19 vaccine, the disease continues to kill thousands of people, mainly due to a lack of sufficient doses for all populations and to the prioritization of populations to be vaccinated. According to epidemiological data from April 06, 2022, the COVID-19 pandemic has already killed more than 6,184,299 people around the world with nearly 494,286,073confirmed cases. To date, no antiviral drug has been officially approved to fight this pandemic. Medical professionals and researchers all over the globe are in pursuit for the discovery therapies against this disease. One of the strategies is the use of medicinal plants. Indeed, plant extracts can inhibit viral growth and their effectiveness has been demonstrated on many viruses encountered in human pathology including SARS-CoV-1, poliovirus, varicella-zoster virus, HIV, human papillomavirus, HSV-1, HSV-2, influenza virus, cytomegalovirus and many others. Besides, it has been shown that plant extracts can regulate immune system and make the body able to prevent the establishment of viral infection or to fight against its deleterious effects. The exploration of plant extracts with anti-viral and immunostimulatory properties could be exploitable in the development of drug against COVID-19. This review promotes medicinal plant extracts as potential anti-COVID-19 drugs.","PeriodicalId":73426,"journal":{"name":"International journal of biomedical engineering and clinical science","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86526249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-30DOI: 10.5121/ijbes.2023.10101
Radjef Lilia, Omari Taha
Pulse transit Time (PTT) is a physiological parameter that is based on characteristics of the pulse waveform, a direct indicator of Cardiovascular Diseases (CVD). The (PTT) is defined as the time taken for the arterial pulse to travel from the heart to a peripheral site. It is commonly derived from Electrocardiogram (ECG) and Photoplethysmogram (PPG) signal calculations and is calculated as the interval between the peak of the electrocardiogram (ECG) R-wave and a time point on the photoplethysmogram (PPG). In this study, we propose a new and lowcomplexity algorithm for the Pulse transit time (PTT) measurement, using these two signals and detecting (PTT- foot) and (PTT- peak). We built a 37 subjects dataset containing a simultaneous recording of the (ECG) and (PPG). The calculation of (PTT) consists of detecting the peak and foot points of a (PPG) and the R-peak of the (ECG) signal. Intermediate operations such as normalization and thresholding to detect the local maxima and minima, are processed on noisy signals, this algorithm is improved by a windowing temporal analysis. The obtained results are promising for the first step. The average sensitivity (SEN) and accuracy (ACC) obtained were (97.5%, and 96.82%) respectively for R-peaks detection and respectively (97.77%, and 97.64%) for (PPG-peak) detection. The sensitivity (SEN) and accuracy (ACC) of (PPG- foot) detection were (98.33%, and 94.14%).
{"title":"A NEW ALGORITHM FOR MEASURING PULSE TRANSIT TIME FROM ECG AND PPG SIGNALS","authors":"Radjef Lilia, Omari Taha","doi":"10.5121/ijbes.2023.10101","DOIUrl":"https://doi.org/10.5121/ijbes.2023.10101","url":null,"abstract":"Pulse transit Time (PTT) is a physiological parameter that is based on characteristics of the pulse waveform, a direct indicator of Cardiovascular Diseases (CVD). The (PTT) is defined as the time taken for the arterial pulse to travel from the heart to a peripheral site. It is commonly derived from Electrocardiogram (ECG) and Photoplethysmogram (PPG) signal calculations and is calculated as the interval between the peak of the electrocardiogram (ECG) R-wave and a time point on the photoplethysmogram (PPG). In this study, we propose a new and lowcomplexity algorithm for the Pulse transit time (PTT) measurement, using these two signals and detecting (PTT- foot) and (PTT- peak). We built a 37 subjects dataset containing a simultaneous recording of the (ECG) and (PPG). The calculation of (PTT) consists of detecting the peak and foot points of a (PPG) and the R-peak of the (ECG) signal. Intermediate operations such as normalization and thresholding to detect the local maxima and minima, are processed on noisy signals, this algorithm is improved by a windowing temporal analysis. The obtained results are promising for the first step. The average sensitivity (SEN) and accuracy (ACC) obtained were (97.5%, and 96.82%) respectively for R-peaks detection and respectively (97.77%, and 97.64%) for (PPG-peak) detection. The sensitivity (SEN) and accuracy (ACC) of (PPG- foot) detection were (98.33%, and 94.14%).","PeriodicalId":73426,"journal":{"name":"International journal of biomedical engineering and clinical science","volume":"81 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135599731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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