Pub Date : 2022-06-30DOI: 10.23937/2469-5769/1510115
Endanda Zawadi E, Imani musimwa P, Tshivwadi Tshilomba A, Tongota Nj
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{"title":"Factors Associated with Neonatal Mortality at Kyeshero Hospital, Goma, North Kivu, DRC","authors":"Endanda Zawadi E, Imani musimwa P, Tshivwadi Tshilomba A, Tongota Nj","doi":"10.23937/2469-5769/1510115","DOIUrl":"https://doi.org/10.23937/2469-5769/1510115","url":null,"abstract":",","PeriodicalId":73466,"journal":{"name":"International journal of pediatric research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47477716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-30DOI: 10.23937/2469-5769/1510097
Ali Reman Ali, Mohammed Ali, Hakim Maamoun
Background: Eosinophilic gastroenteritis is a chronic antigen mediated inflammatory disease that may occur in any part of the intestine, with a significant increase in the incidence in the last years. It might correlate to the increasing in atopic diseases. Materials and methods: An Observational Descriptive study (Case series) was conducted in 57 children with eosinophilic gastroenteritis. They are selected from Pediatric Gastroenterology Clinic, Tishreen University Hospital between September 2016 and September 2021. Results: A total of 57 children, 38 males (66.7%) and 19 females (33.3%) were included in the study. The median age was 5 years, and the most frequent age group was ≤ 3 year (43.9%). Growth failure (45.6%) and abdominal pain (29.8%) represented the most frequent clinical complaints. Many parts of the gastrointestinal tract were affected, and duodenum was the most affected part (63.2%), followed by duodenal bulb (8.8%), colon (5.3%), esophageal (3.5%), and stomach (3.5%). Family history of atopic diseases was present in 29.8% of the cases, especially in both parents (15.8%). The most common atopic features were asthma (36.8%) and allergic rhinitis (31.6%). Milk represented the most frequent food allergen (10.5%), which was diagnosed according to clinical history and food intolerance tests with presence of a significant correlation between food allergy and histological findings (p: 0.02). There were significant differences of the atopic features according to the age groups, in which asthma and allergic rhinitis diagnosed by physicians were more frequent in the older age, whereas other manifestations (urticaria, atopic dermatitis, and food allergy) were more frequent in the children younger than 3 years.
{"title":"The Atopic Diseases in Children Having Eosinophilic Gastroenteritis","authors":"Ali Reman Ali, Mohammed Ali, Hakim Maamoun","doi":"10.23937/2469-5769/1510097","DOIUrl":"https://doi.org/10.23937/2469-5769/1510097","url":null,"abstract":"Background: Eosinophilic gastroenteritis is a chronic antigen mediated inflammatory disease that may occur in any part of the intestine, with a significant increase in the incidence in the last years. It might correlate to the increasing in atopic diseases. Materials and methods: An Observational Descriptive study (Case series) was conducted in 57 children with eosinophilic gastroenteritis. They are selected from Pediatric Gastroenterology Clinic, Tishreen University Hospital between September 2016 and September 2021. Results: A total of 57 children, 38 males (66.7%) and 19 females (33.3%) were included in the study. The median age was 5 years, and the most frequent age group was ≤ 3 year (43.9%). Growth failure (45.6%) and abdominal pain (29.8%) represented the most frequent clinical complaints. Many parts of the gastrointestinal tract were affected, and duodenum was the most affected part (63.2%), followed by duodenal bulb (8.8%), colon (5.3%), esophageal (3.5%), and stomach (3.5%). Family history of atopic diseases was present in 29.8% of the cases, especially in both parents (15.8%). The most common atopic features were asthma (36.8%) and allergic rhinitis (31.6%). Milk represented the most frequent food allergen (10.5%), which was diagnosed according to clinical history and food intolerance tests with presence of a significant correlation between food allergy and histological findings (p: 0.02). There were significant differences of the atopic features according to the age groups, in which asthma and allergic rhinitis diagnosed by physicians were more frequent in the older age, whereas other manifestations (urticaria, atopic dermatitis, and food allergy) were more frequent in the children younger than 3 years.","PeriodicalId":73466,"journal":{"name":"International journal of pediatric research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43965076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-30DOI: 10.23937/2469-5769/1510095
Alotaibi Maha, Aloulou Shaza M
{"title":"Variants in TBCK cause Global Developmental Delay, Dysmorphism, Hypotonia","authors":"Alotaibi Maha, Aloulou Shaza M","doi":"10.23937/2469-5769/1510095","DOIUrl":"https://doi.org/10.23937/2469-5769/1510095","url":null,"abstract":"","PeriodicalId":73466,"journal":{"name":"International journal of pediatric research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47478853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-30DOI: 10.23937/2469-5769/1510085
Wong William
{"title":"Shiga Toxin Producing Escherichia coli Infections and Associated Haemolytic Uraemic Syndrome in New Zealand Children: Twenty Three Years of Epidemiology and Clinical Observations","authors":"Wong William","doi":"10.23937/2469-5769/1510085","DOIUrl":"https://doi.org/10.23937/2469-5769/1510085","url":null,"abstract":"","PeriodicalId":73466,"journal":{"name":"International journal of pediatric research","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68750792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-30DOI: 10.23937/2469-5769/1510096
Ali Getahun, Shimeka Alemayehu, Kassaw Ayalew
Background: Pneumonia is the leading cause of mortality and morbidity in under-five children which accounting two million under-five deaths each year globally. Half of these deaths occur in Sub-Saharan Africa. Regardless of this fact, efforts to identify determinants of pneumonia have been limited in the study area. The aim of this study was to identify determinants of community-acquired pneumonia among 2-59 months of age children in Tehulederie district, Northeast Ethiopia. Methods: An institution-based 1:2 unmatched case-control study was conducted in Tehulederie district from August to September 2017 on 132 cases and 264 control of children aged 2 to 59 months were included in the sample. Cases were children with pneumonia, while controls were nonpneumonia children. Data were entered, coded, and cleaned using Epi-info software version 7 and analyzed using SPSS version 20. The binary logistic regression model was used to test associations between each independent factor with the outcome variable. Variables with P < 0.05 were considered significantly associated with communityacquired pneumonia. Results: Children who lived in the urban (AOR = 2.67, 95% CI: 1.5, 4.7), children who are lived in house without windows (AOR = 4.7, 95% CI: 2.7, 8), children who are lived in house in non-separated animal house (AOR = 3.57 95%CI = 1.7, 7.2), children carried on the back of caregivers during cooking (AOR = 4.7, 95% CI: 2.7, 8), crowded family size (AOR = 2, 95% CI: 1.05, 3.37), and children who had history of diarrhea in the past two weeks prior to data collection (AOR = 3.06, 95% CI: 1.68, 5.86), were found to be determinants of community-acquired pneumonia. Conclusion: Children who lived in the urban, children who are lived in house without windows, children who are lived in house in non-separated animal house, children carried on the back of caregivers during cooking, crowded family size and children who had history of diarrhea in the past two weeks prior to data collection showed a significant association with community-acquired pneumonia.
{"title":"Determinants of Community-Acquired Pneumonia among under-Five Children in Tehulederie District, Northeast Ethiopia","authors":"Ali Getahun, Shimeka Alemayehu, Kassaw Ayalew","doi":"10.23937/2469-5769/1510096","DOIUrl":"https://doi.org/10.23937/2469-5769/1510096","url":null,"abstract":"Background: Pneumonia is the leading cause of mortality and morbidity in under-five children which accounting two million under-five deaths each year globally. Half of these deaths occur in Sub-Saharan Africa. Regardless of this fact, efforts to identify determinants of pneumonia have been limited in the study area. The aim of this study was to identify determinants of community-acquired pneumonia among 2-59 months of age children in Tehulederie district, Northeast Ethiopia. Methods: An institution-based 1:2 unmatched case-control study was conducted in Tehulederie district from August to September 2017 on 132 cases and 264 control of children aged 2 to 59 months were included in the sample. Cases were children with pneumonia, while controls were nonpneumonia children. Data were entered, coded, and cleaned using Epi-info software version 7 and analyzed using SPSS version 20. The binary logistic regression model was used to test associations between each independent factor with the outcome variable. Variables with P < 0.05 were considered significantly associated with communityacquired pneumonia. Results: Children who lived in the urban (AOR = 2.67, 95% CI: 1.5, 4.7), children who are lived in house without windows (AOR = 4.7, 95% CI: 2.7, 8), children who are lived in house in non-separated animal house (AOR = 3.57 95%CI = 1.7, 7.2), children carried on the back of caregivers during cooking (AOR = 4.7, 95% CI: 2.7, 8), crowded family size (AOR = 2, 95% CI: 1.05, 3.37), and children who had history of diarrhea in the past two weeks prior to data collection (AOR = 3.06, 95% CI: 1.68, 5.86), were found to be determinants of community-acquired pneumonia. Conclusion: Children who lived in the urban, children who are lived in house without windows, children who are lived in house in non-separated animal house, children carried on the back of caregivers during cooking, crowded family size and children who had history of diarrhea in the past two weeks prior to data collection showed a significant association with community-acquired pneumonia.","PeriodicalId":73466,"journal":{"name":"International journal of pediatric research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46360734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-30DOI: 10.23937/2469-5769/1510092
Perez Maria Anna F, Nancho Rosa Maria, Salonga-Quimpo Rhea
{"title":"Transition from Pediatric to Adult Care of Pediatric Patients with Chronic Disease: Experiences and Perspectives of Pediatricians and Internists at a Private Tertiary Hospital in the Philippines","authors":"Perez Maria Anna F, Nancho Rosa Maria, Salonga-Quimpo Rhea","doi":"10.23937/2469-5769/1510092","DOIUrl":"https://doi.org/10.23937/2469-5769/1510092","url":null,"abstract":"","PeriodicalId":73466,"journal":{"name":"International journal of pediatric research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42268627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Pediatric Abusive Head Trauma: A Case Series in a Tertiary Hospital","authors":"Marinhas Andreia, Martins Ana Isabel, Fazendeiro Anabela, Lourenço Patrícia, Freitas Filomena, Machado Marta, Vale Beatriz Maia","doi":"10.23937/2469-5769/1510093","DOIUrl":"https://doi.org/10.23937/2469-5769/1510093","url":null,"abstract":"","PeriodicalId":73466,"journal":{"name":"International journal of pediatric research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45952402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-09DOI: 10.23937/2469-5769/1510089
Mansour Hanin Ahmed, I. Ali, M. Ali
Introduction: Constipation is one of the common problems in childhood. Recently, Polyethylene Glycol (PEG 3350) has been suggested as a good alternative laxative to Lactulose as a treatment option in pediatric constipation. The current study aimed to compare the efficacy of two laxatives (PEG 3350 and Lactulose) in the management of functional constipation and evaluate the side effects. Methods and materials: In an open-label clinical trial, 1-13 year-old children with functional constipation according to ROME IV criteria and the presence of RAIR based on anorectal manometry were studied. The patients were randomized to receive either PEG3350 (0.8 g/kg/d) or Lactulose (2 ml/kg/d). Both groups received the medication orally in two divided doses for 12 weeks. They were evaluated clinically at the end of 4, 8, and 12 weeks of therapy, and the end of 16 and 20 weeks from enrolment. At the end of the 12th week, Success was defined as a defecation frequency ≥ 3/week and improvement in stool consistency without painful defecation, as well as encopresis ≤ 1 every two weeks. Results: We enrolled 43 patients (M20, F23) aged 4.16 ± 2.3 years. At the end of the 12th week, good clinical outcomes were achieved in 95% (PEG) and 77.3% (Lactulose). The PEG group had a significant increase in defecations in a week compared with the Lactulose group (6.26 ± 0.5 vs. 4.94 ± 0.8, p = 0.0001) and a significant decrease in encopresis (35% vs. 10, p = 0.01). PEG achieved defecation without pain (0% vs. 22.7%) and less hard stools (5% vs. 18.2%, p = 0.1). Patients reported less abdominal pain and bloating than children using Lactulose (25% and 0% vs. 68.2% and 27.3%, respectively). We reported a significant relapse because of sudden ceasession of treatment in the Lactulose group (13.6% vs. 5%, p = 0.04) compared with the PEG group. Conclusion: PEG3350 compared with Lactulose provided a higher success rate, less relapse rate, and fewer side effects in the treatment of constipated children.
导读:便秘是儿童时期常见的问题之一。最近，聚乙二醇(PEG 3350)被认为是一种很好的替代乳果糖的泻药，作为儿童便秘的治疗选择。本研究旨在比较两种泻药(PEG 3350和乳果糖)治疗功能性便秘的疗效并评估其副作用。方法和材料:在一项开放标签临床试验中，研究了1-13岁的功能性便秘儿童，根据ROME IV标准和基于肛门直肠测压法的RAIR存在。患者随机接受PEG3350 (0.8 g/kg/d)或乳果糖(2 ml/kg/d)治疗。两组均口服两剂，疗程12周。在治疗4周、8周和12周结束时，以及入组后16周和20周结束时，对患者进行临床评估。在第12周结束时，成功定义为排便频率≥3次/周，大便一致性改善，无排便疼痛，每两周小便≤1次。结果:纳入患者43例(M20例，F23例)，年龄4.16±2.3岁。在第12周结束时，95% (PEG)和77.3%(乳果糖)的临床结果良好。与乳果糖组相比，聚乙二醇组一周内排便量显著增加(6.26±0.5比4.94±0.8,p = 0.0001)，粪尿率显著降低(35%比10,p = 0.01)。PEG实现了无痛排便(0%比22.7%)和较少的硬便(5%比18.2%，p = 0.1)。与使用乳果糖的儿童相比，患者报告的腹痛和腹胀较少(分别为25%和0% vs. 68.2%和27.3%)。我们报道，与PEG组相比，乳果糖组因突然停止治疗而显著复发(13.6% vs. 5%， p = 0.04)。结论:与乳果糖相比，PEG3350治疗便秘患儿的成功率更高，复发率更低，副作用更小。
{"title":"Effectiveness of Polyethylene Glycol 3350 versus Lactulose in Management of Functional Constipation in Children","authors":"Mansour Hanin Ahmed, I. Ali, M. Ali","doi":"10.23937/2469-5769/1510089","DOIUrl":"https://doi.org/10.23937/2469-5769/1510089","url":null,"abstract":"Introduction: Constipation is one of the common problems in childhood. Recently, Polyethylene Glycol (PEG 3350) has been suggested as a good alternative laxative to Lactulose as a treatment option in pediatric constipation. The current study aimed to compare the efficacy of two laxatives (PEG 3350 and Lactulose) in the management of functional constipation and evaluate the side effects. Methods and materials: In an open-label clinical trial, 1-13 year-old children with functional constipation according to ROME IV criteria and the presence of RAIR based on anorectal manometry were studied. The patients were randomized to receive either PEG3350 (0.8 g/kg/d) or Lactulose (2 ml/kg/d). Both groups received the medication orally in two divided doses for 12 weeks. They were evaluated clinically at the end of 4, 8, and 12 weeks of therapy, and the end of 16 and 20 weeks from enrolment. At the end of the 12th week, Success was defined as a defecation frequency ≥ 3/week and improvement in stool consistency without painful defecation, as well as encopresis ≤ 1 every two weeks. Results: We enrolled 43 patients (M20, F23) aged 4.16 ± 2.3 years. At the end of the 12th week, good clinical outcomes were achieved in 95% (PEG) and 77.3% (Lactulose). The PEG group had a significant increase in defecations in a week compared with the Lactulose group (6.26 ± 0.5 vs. 4.94 ± 0.8, p = 0.0001) and a significant decrease in encopresis (35% vs. 10, p = 0.01). PEG achieved defecation without pain (0% vs. 22.7%) and less hard stools (5% vs. 18.2%, p = 0.1). Patients reported less abdominal pain and bloating than children using Lactulose (25% and 0% vs. 68.2% and 27.3%, respectively). We reported a significant relapse because of sudden ceasession of treatment in the Lactulose group (13.6% vs. 5%, p = 0.04) compared with the PEG group. Conclusion: PEG3350 compared with Lactulose provided a higher success rate, less relapse rate, and fewer side effects in the treatment of constipated children.","PeriodicalId":73466,"journal":{"name":"International journal of pediatric research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46560121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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