Pub Date : 2013-06-26DOI: 10.3968/J.ANS.1715787020120602.2560
Cong Yu, Xuefeng Wang, J. Ma
This paper analyzes spurious regression phenomenon involving AR(p) stable processes with trend breaks. It shows that when those time series are used in ordinary least squares regression, the convenient t-ratios procedures wrongly indicate that the spurious relationship is present as the pair of independent stable series contains trend changes. The spurious relationship becomes stronger as the sample size approaches to infinite. As a result, spurious effects might occur more often than we previously believed as they can arise even between AR(p) stable series in present of trend breaks.
{"title":"Spurious Relationship of AR(P) Stable Sequences in Presence of Trends Breaks","authors":"Cong Yu, Xuefeng Wang, J. Ma","doi":"10.3968/J.ANS.1715787020120602.2560","DOIUrl":"https://doi.org/10.3968/J.ANS.1715787020120602.2560","url":null,"abstract":"This paper analyzes spurious regression phenomenon involving AR(p) stable processes with trend breaks. It shows that when those time series are used in ordinary least squares regression, the convenient t-ratios procedures wrongly indicate that the spurious relationship is present as the pair of independent stable series contains trend changes. The spurious relationship becomes stronger as the sample size approaches to infinite. As a result, spurious effects might occur more often than we previously believed as they can arise even between AR(p) stable series in present of trend breaks.","PeriodicalId":7348,"journal":{"name":"Advances in Natural Science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85575480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2013-06-26DOI: 10.3968/J.ANS.1715787020120602.2432
K. A. Ravikumar, P. A. Kurup
Neanderthal genes have been related to human disease. The human genome has been found to have up to 10 percent Neanderthal genes. The pyruvate dehydrogenase gene as well as those coding for MHC alleles are of Neanderthal origin. Neanderthal genes have been related to autism and autoimmune disease. There is high incidence of autism and Neanderthal anthropometry in the matrilineal and Dravidian language speaking nair community of Kerala. The autistic brain is comparable to the large-sized Neanderthal brain. Metabolic patterns were compared among the following groups: matrilineal nairs, non nairs, autism, schizophrenia and systemic diseases to find out a pattern of Neanderthal metabolism. The aim of the study aimed to detect fossilized Neanderthal matrilineal societies and new Neanderthal hybrids in relation to civilisational diseases. Four groups, 25 numbers in each group were chosen for the study—the autistic population diagnosed according to DSM criteria, the normal nair population, the normal non-nair population and civilisational disease group including metabolic syndrome x, alzheimer’s disease, cancer, schizophrenia and multiple sclerosis. Archaeal cholesterol catabolism as well as PDH activity, glycolytic pathway, the GABA shunt, porphyrins, homocysteine and ammonia metabolism were studied to find out a pattern of Neanderthal metabolism. Autistic metabolonomic patterns include low pyruvate dehydrogenase activity, mitochondrial dysfunction, GABA shunt, Warburg glycolytic phenotype, hyperammonemia, hyperhomocysteinemia, porphyria, low cholesterol/bile acid levels and a similar pattern is seen in the normal nair population of Kerala. Neanderthal metabolonomic patterns include a low efficiency PDH activity. Autistic and matrilineal societies like nair can be considered as remnants of the Neanderthals. The autistic and nair population have increased cytochrome F420 activity suggestive of endosymbiotic archaeal growth resulting in PDH and mitochondrial suppression. The increased archaeal digoxin synthesis later on shuts down the metabolic machinery the neuronal and other tissue cells and the human cells and tissues including the brain are taken over by an atavistic actinidic colony network. This leads onto a Neanderthal hybrid zombie syndrome. The increased archaeal growth in ice age conditions contributed to the neanderthal evolution and similar endosymbiotic archaeal growth related to global warming leads to neanderthalisation of homo sapiens. The autistic and neanderthalic metabolonomic patterns are also seen in civilisational diseases like syndrome X, schizophrenia, cancer, multiple sclerosis and alzheimer’s disease. The results suggest neanderthalisation of the humans due to global warming and archaeal growth. The Neanderthalisation of the human species is the basis of the global autistic, schizophrenic and civilisational disease epidemic—epidemic Neanderthal hybrid zombie syndrome. The matrilineal societies are fossilized Neanderthal remnants
{"title":"Fossilised Neanderthal Matrilineal Societies, Neo-Neanderthal Hybrids, Endosymbiotic Actinidic Archaea and Civilisational Diseases","authors":"K. A. Ravikumar, P. A. Kurup","doi":"10.3968/J.ANS.1715787020120602.2432","DOIUrl":"https://doi.org/10.3968/J.ANS.1715787020120602.2432","url":null,"abstract":"Neanderthal genes have been related to human disease. The human genome has been found to have up to 10 percent Neanderthal genes. The pyruvate dehydrogenase gene as well as those coding for MHC alleles are of Neanderthal origin. Neanderthal genes have been related to autism and autoimmune disease. There is high incidence of autism and Neanderthal anthropometry in the matrilineal and Dravidian language speaking nair community of Kerala. The autistic brain is comparable to the large-sized Neanderthal brain. Metabolic patterns were compared among the following groups: matrilineal nairs, non nairs, autism, schizophrenia and systemic diseases to find out a pattern of Neanderthal metabolism. The aim of the study aimed to detect fossilized Neanderthal matrilineal societies and new Neanderthal hybrids in relation to civilisational diseases. Four groups, 25 numbers in each group were chosen for the study—the autistic population diagnosed according to DSM criteria, the normal nair population, the normal non-nair population and civilisational disease group including metabolic syndrome x, alzheimer’s disease, cancer, schizophrenia and multiple sclerosis. Archaeal cholesterol catabolism as well as PDH activity, glycolytic pathway, the GABA shunt, porphyrins, homocysteine and ammonia metabolism were studied to find out a pattern of Neanderthal metabolism. Autistic metabolonomic patterns include low pyruvate dehydrogenase activity, mitochondrial dysfunction, GABA shunt, Warburg glycolytic phenotype, hyperammonemia, hyperhomocysteinemia, porphyria, low cholesterol/bile acid levels and a similar pattern is seen in the normal nair population of Kerala. Neanderthal metabolonomic patterns include a low efficiency PDH activity. Autistic and matrilineal societies like nair can be considered as remnants of the Neanderthals. The autistic and nair population have increased cytochrome F420 activity suggestive of endosymbiotic archaeal growth resulting in PDH and mitochondrial suppression. The increased archaeal digoxin synthesis later on shuts down the metabolic machinery the neuronal and other tissue cells and the human cells and tissues including the brain are taken over by an atavistic actinidic colony network. This leads onto a Neanderthal hybrid zombie syndrome. The increased archaeal growth in ice age conditions contributed to the neanderthal evolution and similar endosymbiotic archaeal growth related to global warming leads to neanderthalisation of homo sapiens. The autistic and neanderthalic metabolonomic patterns are also seen in civilisational diseases like syndrome X, schizophrenia, cancer, multiple sclerosis and alzheimer’s disease. The results suggest neanderthalisation of the humans due to global warming and archaeal growth. The Neanderthalisation of the human species is the basis of the global autistic, schizophrenic and civilisational disease epidemic—epidemic Neanderthal hybrid zombie syndrome. The matrilineal societies are fossilized Neanderthal remnants","PeriodicalId":7348,"journal":{"name":"Advances in Natural Science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78407258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2013-06-26DOI: 10.3968/J.ANS.1715787020120602.2121
Chih-Yueh Wang
Relativistic thermodynamics is a relatively unknown theory. Thermodynamic laws apply only to quasi-static processes that quickly change between states that are in a long-term equilibrium. However, special relativity postulates that the propagation speed of physical signals is constrained, thus limiting the speed of change in thermal states. Einstein was especially interested in the concept of temperature and the transformation formula of thermodynamic quantities in a moving frame of reference, having inspired numerous investigations for two centuries. This article reviews the historical development of relativistic thermodynamics since Einstein, beginning from the initial idea of Planck-Einstein in which a moving body warms up, to the notion of Blanusa-Ott in which a moving body cools down, and to that of Landsberg in which the temperature remains unchanged—depending on how the observer’s thermometer is defined. Current research focuses on identifying the correct form of relativistic Maxwell distribution to validate the related theory. Recent computational results using molecular dynamic simulations and their relevance to astrophysics are outlined as well.
{"title":"Thermodynamics Since Einstein","authors":"Chih-Yueh Wang","doi":"10.3968/J.ANS.1715787020120602.2121","DOIUrl":"https://doi.org/10.3968/J.ANS.1715787020120602.2121","url":null,"abstract":"Relativistic thermodynamics is a relatively unknown theory. Thermodynamic laws apply only to quasi-static processes that quickly change between states that are in a long-term equilibrium. However, special relativity postulates that the propagation speed of physical signals is constrained, thus limiting the speed of change in thermal states. Einstein was especially interested in the concept of temperature and the transformation formula of thermodynamic quantities in a moving frame of reference, having inspired numerous investigations for two centuries. This article reviews the historical development of relativistic thermodynamics since Einstein, beginning from the initial idea of Planck-Einstein in which a moving body warms up, to the notion of Blanusa-Ott in which a moving body cools down, and to that of Landsberg in which the temperature remains unchanged—depending on how the observer’s thermometer is defined. Current research focuses on identifying the correct form of relativistic Maxwell distribution to validate the related theory. Recent computational results using molecular dynamic simulations and their relevance to astrophysics are outlined as well.","PeriodicalId":7348,"journal":{"name":"Advances in Natural Science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82133500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Volobuev Andrey Nikolaevich, Romanchuk Peter Ivanovich, Malishev Vladimir Kirikovich
Comparison of concepts of occurrence and accumulation of the genetic load in result of inbreeding for a family tree and a population is given. It is shown that for the population the analysis of the genetic load concerns to area of nonlinear genetics. The nonlinear differential equation of the second order being the special case of the Hardy-Weinberg law at presence inbreeding for the population is found. The numerical decision of this equation allowed to find the law of increase of recessive allele frequency in the population is given. Some aspects of the traditional theory of the genetic load are considered.
{"title":"Nonlinear Genetics Inbreeding and Genetic Load","authors":"Volobuev Andrey Nikolaevich, Romanchuk Peter Ivanovich, Malishev Vladimir Kirikovich","doi":"10.3968/4164","DOIUrl":"https://doi.org/10.3968/4164","url":null,"abstract":"Comparison of concepts of occurrence and accumulation of the genetic load in result of inbreeding for a family tree and a population is given. It is shown that for the population the analysis of the genetic load concerns to area of nonlinear genetics. The nonlinear differential equation of the second order being the special case of the Hardy-Weinberg law at presence inbreeding for the population is found. The numerical decision of this equation allowed to find the law of increase of recessive allele frequency in the population is given. Some aspects of the traditional theory of the genetic load are considered.","PeriodicalId":7348,"journal":{"name":"Advances in Natural Science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88285937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2013-03-26DOI: 10.3968/J.ANS.1715787020130601.2407
A. J. Henry, G. William, O. Effiong
A study was conducted to assess the effect of orange waste meal as an alternative fibre source on linear body measurements of rabbits. Twenty-four (24) weaned rabbits of cross breed and mixed sexes were used for the study. Experimental animals which weighed between 676.67g to 686.67g were allotted to four dietary treatments in a completely randomized design. Results of the study showed that head length (HL), body length (BL), heart girth (HG), length of hind limb (LHL) and length of fore limb (LFL) differed (p 0.05) statistically between the treatment groups. At the end of the experimental period of ten weeks, rabbits fed diet T 4 (endocarp + mesocarp) recorded higher (p 0.05) influenced by dietary treatments. Therefore, rabbits can effectively utilize orange waste meal as an alternative fibre source without adverse effects on linear body measurements and carcass characteristics.
{"title":"Linear Body Measurements and Carcass Characteristics of Rabbits Fed Orange (Citrus sinensis) Waste Meal as Alternative Fibre Source in Diet","authors":"A. J. Henry, G. William, O. Effiong","doi":"10.3968/J.ANS.1715787020130601.2407","DOIUrl":"https://doi.org/10.3968/J.ANS.1715787020130601.2407","url":null,"abstract":"A study was conducted to assess the effect of orange waste meal as an alternative fibre source on linear body measurements of rabbits. Twenty-four (24) weaned rabbits of cross breed and mixed sexes were used for the study. Experimental animals which weighed between 676.67g to 686.67g were allotted to four dietary treatments in a completely randomized design. Results of the study showed that head length (HL), body length (BL), heart girth (HG), length of hind limb (LHL) and length of fore limb (LFL) differed (p 0.05) statistically between the treatment groups. At the end of the experimental period of ten weeks, rabbits fed diet T 4 (endocarp + mesocarp) recorded higher (p 0.05) influenced by dietary treatments. Therefore, rabbits can effectively utilize orange waste meal as an alternative fibre source without adverse effects on linear body measurements and carcass characteristics.","PeriodicalId":7348,"journal":{"name":"Advances in Natural Science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85020887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Effect of external electric field (EEF) of 0.001, 0.005 and 0.01 a.u. upon molecular energy, charge distribution and dipole moments of non-dissociated and inner salt forms of selected dipeptides formed from alanine (Ala), glutamic acid (GluA), and ornithine (Orn) that is, Ala-Ala, Ala-GluA, GluA-Ala, Ala-Orn, Orn-Ala involving α-amino group of Orn and Orn-Ala involving δ-amino group of Orn. For that purpose HyperChem 8.0 software was used together with the AM1 method for optimization of the conformation of the molecules in a computer vacuum.
{"title":"Effect of External Electric Field Upon Selected Model Dipeptides","authors":"J. Mazurkiewicz, P. Tomasik","doi":"10.3968/4294","DOIUrl":"https://doi.org/10.3968/4294","url":null,"abstract":"Effect of external electric field (EEF) of 0.001, 0.005 and 0.01 a.u. upon molecular energy, charge distribution and dipole moments of non-dissociated and inner salt forms of selected dipeptides formed from alanine (Ala), glutamic acid (GluA), and ornithine (Orn) that is, Ala-Ala, Ala-GluA, GluA-Ala, Ala-Orn, Orn-Ala involving α-amino group of Orn and Orn-Ala involving δ-amino group of Orn. For that purpose HyperChem 8.0 software was used together with the AM1 method for optimization of the conformation of the molecules in a computer vacuum.","PeriodicalId":7348,"journal":{"name":"Advances in Natural Science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84881047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2013-03-26DOI: 10.3968/J.ANS.1715787020130601.1630
J. Agunsoye, S. I. Talabi, V. Aigbodion, A. Olumuyiwa
Particulate filled polymeric composites are becoming attractive because of their wide applications and lower production cost. To evaluate the possibility of using waste silica based ceramic materials as reinforcing filler in recycled polyethylene (PE) composite, the effect of ceramic (PC) particle sizes on the mechanical, wear and thermal behaviours of polyethylene (PE) composites were investigated at (2wt% filler) and grain sizes (40µm-150µm). The wear behaviour was characterized using analysis of variance (ANOVA) and linear regression to determine the main and interactive effects of the process parameters such as speed, load and time on the wear behaviour of the fabricated PE-PC composites. Test results show that the decreasing the ceramic particles 150µm-40µm improved the mechanical, wear and thermal properties of the recycled polyethylene (PE) composites. Factorial design of the experiment can be successfully employed to describe the wear behavior of the samples and developed linear equation for predicting wear rate with in selected experimental conditions.
{"title":"Effects of Silica Ceramic Particle Sizes on the Properties of Recycled Polyethylene Composites","authors":"J. Agunsoye, S. I. Talabi, V. Aigbodion, A. Olumuyiwa","doi":"10.3968/J.ANS.1715787020130601.1630","DOIUrl":"https://doi.org/10.3968/J.ANS.1715787020130601.1630","url":null,"abstract":"Particulate filled polymeric composites are becoming attractive because of their wide applications and lower production cost. To evaluate the possibility of using waste silica based ceramic materials as reinforcing filler in recycled polyethylene (PE) composite, the effect of ceramic (PC) particle sizes on the mechanical, wear and thermal behaviours of polyethylene (PE) composites were investigated at (2wt% filler) and grain sizes (40µm-150µm). The wear behaviour was characterized using analysis of variance (ANOVA) and linear regression to determine the main and interactive effects of the process parameters such as speed, load and time on the wear behaviour of the fabricated PE-PC composites. Test results show that the decreasing the ceramic particles 150µm-40µm improved the mechanical, wear and thermal properties of the recycled polyethylene (PE) composites. Factorial design of the experiment can be successfully employed to describe the wear behavior of the samples and developed linear equation for predicting wear rate with in selected experimental conditions.","PeriodicalId":7348,"journal":{"name":"Advances in Natural Science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89965730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Actinidic archaea has been related to global warming and human diseases especially autoimmune disease, neuro-degeneration, neuropsychiatric disorder, neoplasm and metabolic syndrome x. The growth of endosymbiotic actinidic archaea in relation to climate change and global warming leads to nean-derthalisation of the human mind-body system. Neanderthal anthropometry and metabolonomics has been described in autoimmune disease, neuro-degeneration, neuropsychiatric disorder, neoplasm and metabolic syndrome x especially the Warburg phenotype and hyperdigoxinemia. Digoxin produced by archaeal cholesterol catabolism produces Nean-derthalisation. Prefrontal cortical atrophy and cerebellar hyperplasia has been related to autoimmune disease, neuro-degeneration, neuropsychiatric disorder, neoplasm and metabolic syndrome x in this communication. This leads on to dysautonomia with sympathetic hyperactivity and parasympathetic neuropathy in these disorders. Actinidic archaeal related cerebellar dominance leads to changes in brain function. The data is described in this paper.
{"title":"Climate Change Mediated Actinidic Archaeal Endosymbiosis Generates Neanderthal Hybrids and Mind-Body Phenotypic Change","authors":"R. Kurup, P. A. Kurup","doi":"10.3968/3925","DOIUrl":"https://doi.org/10.3968/3925","url":null,"abstract":"Actinidic archaea has been related to global warming and human diseases especially autoimmune disease, neuro-degeneration, neuropsychiatric disorder, neoplasm and metabolic syndrome x. The growth of endosymbiotic actinidic archaea in relation to climate change and global warming leads to nean-derthalisation of the human mind-body system. Neanderthal anthropometry and metabolonomics has been described in autoimmune disease, neuro-degeneration, neuropsychiatric disorder, neoplasm and metabolic syndrome x especially the Warburg phenotype and hyperdigoxinemia. Digoxin produced by archaeal cholesterol catabolism produces Nean-derthalisation. Prefrontal cortical atrophy and cerebellar hyperplasia has been related to autoimmune disease, neuro-degeneration, neuropsychiatric disorder, neoplasm and metabolic syndrome x in this communication. This leads on to dysautonomia with sympathetic hyperactivity and parasympathetic neuropathy in these disorders. Actinidic archaeal related cerebellar dominance leads to changes in brain function. The data is described in this paper.","PeriodicalId":7348,"journal":{"name":"Advances in Natural Science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91296440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: The climate change and global warming/ice age results in endosymbiotic actinidic archaeal growth in the human system and cholesterol catabolism resulting in endogenous digoxin synthesis. The increased endosymbiotic archaeal growth detected in autism and matrilineal communities with increased incidence of autism and neanderthalic origin leads to the conclusion that digoxin acts as neanderthalic hormone. The increased endosymbiotic archaeal growth and resultant endogenous digoxin synthesis in relation to climate change and global warming results in neanderthalisation of homo sapiens and human disease resulting in homo sapien extinction. Digoxin can inhibit reverse transcriptase activity and RNA editing resulting in suppression of endogenous retroviral growth. This produces inhibition of HERV expression and jumping gene phenomena producing in adynamicity of the human genome. HERV related jumping genes are crucial in synaptic diversity, HLA expression and immunomodulation as well as metabolic diversity. Digoxin produces alteration in sodium-hydrogen exchange producing an acidic pH and acts like a growth factor producing stem cell transformation of adult cells. Stem cells have a distinct metabolism with increased glycolysis and suppression of PDH and mitochondrial function. This can result in cancer and metabolic syndrome. The digoxin interference with RNA editing can lead to mutated RNA viruses and wide spread RNA viral epidemics. The digoxin interference with HERV expression and RNA editing and resultant inhibition of genomic, metabolic, neural and immune diversity produces autoimmune disease, cancer, metabolic syndrome, degenerations, schizophrenia and autism which are increasing at epidemic rates in human population. Materials and Methods: Endogenous digoxin levels and serum cytochrome F420 levels as a marker of archaeal growth were estimated in matrilineal communities, SLE, multiple sclerosis, parkinson’s disease, alzheimer’s disease, CNS glioma, multiple myeloma, metabolic syndrome x with CAD and CVA, schizophrenia and autism. 15 numbers were included in each group and each patient had an age and sex matched control. Endogenous digoxin was estimated by Elisa and cytochrome F420 estimated by spectrophotometry. The statistical analysis was done by ANOVA. Results: Endogenous digoxin levels and cytochrome F420 levels were elevated in matrilineal neanderthalic communities, SLE, multiple sclerosis, parkinson’s disease, alzheimer’s disease, CNS glioma, multiple myeloma, metabolic syndrome x with CAD and CVA, schizophrenia and autism. Endogenous digoxin and cytochrome F420 levels were low in non-matrilineal homo sapien population. Conclusion: Homo sapiens tend to have low levels of endosymbiotic actinidic archaea and low digoxin synthesis. Homo sapiens have low incidence of autoimmune disease, cancer, schizophrenia, autism and metabolic syndrome. The neanderthalisation of homo sapiens consequent to endosymbiotic actinidic archaeal growth a
{"title":"Archaeal Symbiosis and Digoxin Status Modulates Evolution of Homo Sapiens and Homo Neanderthalis - Digoxin Is a Neanderthal Hormone","authors":"R. Kurup, P. A. Kurup","doi":"10.3968/4382","DOIUrl":"https://doi.org/10.3968/4382","url":null,"abstract":"Introduction: The climate change and global warming/ice age results in endosymbiotic actinidic archaeal growth in the human system and cholesterol catabolism resulting in endogenous digoxin synthesis. The increased endosymbiotic archaeal growth detected in autism and matrilineal communities with increased incidence of autism and neanderthalic origin leads to the conclusion that digoxin acts as neanderthalic hormone. The increased endosymbiotic archaeal growth and resultant endogenous digoxin synthesis in relation to climate change and global warming results in neanderthalisation of homo sapiens and human disease resulting in homo sapien extinction. Digoxin can inhibit reverse transcriptase activity and RNA editing resulting in suppression of endogenous retroviral growth. This produces inhibition of HERV expression and jumping gene phenomena producing in adynamicity of the human genome. HERV related jumping genes are crucial in synaptic diversity, HLA expression and immunomodulation as well as metabolic diversity. Digoxin produces alteration in sodium-hydrogen exchange producing an acidic pH and acts like a growth factor producing stem cell transformation of adult cells. Stem cells have a distinct metabolism with increased glycolysis and suppression of PDH and mitochondrial function. This can result in cancer and metabolic syndrome. The digoxin interference with RNA editing can lead to mutated RNA viruses and wide spread RNA viral epidemics. The digoxin interference with HERV expression and RNA editing and resultant inhibition of genomic, metabolic, neural and immune diversity produces autoimmune disease, cancer, metabolic syndrome, degenerations, schizophrenia and autism which are increasing at epidemic rates in human population. Materials and Methods: Endogenous digoxin levels and serum cytochrome F420 levels as a marker of archaeal growth were estimated in matrilineal communities, SLE, multiple sclerosis, parkinson’s disease, alzheimer’s disease, CNS glioma, multiple myeloma, metabolic syndrome x with CAD and CVA, schizophrenia and autism. 15 numbers were included in each group and each patient had an age and sex matched control. Endogenous digoxin was estimated by Elisa and cytochrome F420 estimated by spectrophotometry. The statistical analysis was done by ANOVA. Results: Endogenous digoxin levels and cytochrome F420 levels were elevated in matrilineal neanderthalic communities, SLE, multiple sclerosis, parkinson’s disease, alzheimer’s disease, CNS glioma, multiple myeloma, metabolic syndrome x with CAD and CVA, schizophrenia and autism. Endogenous digoxin and cytochrome F420 levels were low in non-matrilineal homo sapien population. Conclusion: Homo sapiens tend to have low levels of endosymbiotic actinidic archaea and low digoxin synthesis. Homo sapiens have low incidence of autoimmune disease, cancer, schizophrenia, autism and metabolic syndrome. The neanderthalisation of homo sapiens consequent to endosymbiotic actinidic archaeal growth a","PeriodicalId":7348,"journal":{"name":"Advances in Natural Science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85424963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
INTRODUCTION: The postulated Lemurian part of the Indian sub-continent in South India is inhabited by the dominant Nair community. The dominant Nair community also has a high incidence of autism. Neanderthal anthropometric features have been described in autism. Neanderthal metabolonomics have also been described in autism. It is possible that homo neanderthalis would have originated in the super continent which occupied the southern ocean. The island of Sumatra is home to another human species homo floresiensis which lived along with homo neanderthalis. This suggests an oceanic origin of homo neanderthalis in the supercontinent in the southern ocean. Recurrent Tsunamis would have forced the migration of homo neanderthalis to the Eurasian land mass especially to Harappa, Sumeria, Etruscia, Egypt and Basque country. There is a high incidence of Neanderthal genes in the Basque population. The language spoken in Harappa, Sumeria, Etruscia, Egypt and Basque country had a Dravidian sub-stratum. The population in these areas are matrilineal and female dominant. MATERIALS AND METHODS: Neanderthal anthropometric features were evaluated in the Nair community and in autism. The parameters checked include dolichocephalic skull, prominent supraorbital ridge and mid face large flat nose and ring finger index finger ratios. RESULTS: The Nair community had a high prevalence of Neanderthal anthropometric features. Neanderthal anthropometric features were also dominant in autism. CONCLUSION: This suggests an out of oceania hypothesis for the origin of homo neanderthalis.
{"title":"The Homo Neanderthalis and the Dravidians: A Common Origin and Relation to Harappan Civilisation and Vedas","authors":"R. Kurup, P. A. Kurup","doi":"10.3968/4384","DOIUrl":"https://doi.org/10.3968/4384","url":null,"abstract":"INTRODUCTION: The postulated Lemurian part of the Indian sub-continent in South India is inhabited by the dominant Nair community. The dominant Nair community also has a high incidence of autism. Neanderthal anthropometric features have been described in autism. Neanderthal metabolonomics have also been described in autism. It is possible that homo neanderthalis would have originated in the super continent which occupied the southern ocean. The island of Sumatra is home to another human species homo floresiensis which lived along with homo neanderthalis. This suggests an oceanic origin of homo neanderthalis in the supercontinent in the southern ocean. Recurrent Tsunamis would have forced the migration of homo neanderthalis to the Eurasian land mass especially to Harappa, Sumeria, Etruscia, Egypt and Basque country. There is a high incidence of Neanderthal genes in the Basque population. The language spoken in Harappa, Sumeria, Etruscia, Egypt and Basque country had a Dravidian sub-stratum. The population in these areas are matrilineal and female dominant. MATERIALS AND METHODS: Neanderthal anthropometric features were evaluated in the Nair community and in autism. The parameters checked include dolichocephalic skull, prominent supraorbital ridge and mid face large flat nose and ring finger index finger ratios. RESULTS: The Nair community had a high prevalence of Neanderthal anthropometric features. Neanderthal anthropometric features were also dominant in autism. CONCLUSION: This suggests an out of oceania hypothesis for the origin of homo neanderthalis.","PeriodicalId":7348,"journal":{"name":"Advances in Natural Science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91040730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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