Deniz Heydarian, M. Flavel, Mihiri Munasinghe, Abdullah Almotayri, Markandeya Jois, Jency Thomas
Previous research has established that polyphenols increase lifespan and stress resistance in C. elegans. However, the effects of timing of exposure on the extension of lifespan and the mechanisms involved are not completely understood. This study aims to clarify the influence of the timing of polyphenol-rich sugarcane extract (PRSE) administration on the lifespan of Caenorhabditis elegans. C. elegans worms were subjected to a diet containing PRSE powder at various larval stages until their death. The optimal concentration for lifespan extension was found to be 5 mg/mL PRSE, which increased the lifespan of N2 worms by 18.12% compared to the control group. Mutant strains were also tested, and worm thermotolerance assays were used to assess age-related health at different life stages. Lifespan was notably extended when PRSE was introduced at the first larval stage and 15 h thereafter. No significant extension of lifespan was observed when introduced later in life. The lifespan of DAF-16 and DAF-2 mutants remained unaffected by PRSE. Improved thermotolerance was observed, especially in young and middle-aged worms. Early initiation and sustained intake of PRSE might improve the heat stress and lifespan, implicating the insulin/IGF-1 signaling pathway as a likely mediator in C. elegans.
{"title":"Early Exposure to Polyphenol-Rich Sugarcane Extract (PRSE) Mitigates Aging While Enhancing Thermotolerance in C. elegans","authors":"Deniz Heydarian, M. Flavel, Mihiri Munasinghe, Abdullah Almotayri, Markandeya Jois, Jency Thomas","doi":"10.3390/jal4010002","DOIUrl":"https://doi.org/10.3390/jal4010002","url":null,"abstract":"Previous research has established that polyphenols increase lifespan and stress resistance in C. elegans. However, the effects of timing of exposure on the extension of lifespan and the mechanisms involved are not completely understood. This study aims to clarify the influence of the timing of polyphenol-rich sugarcane extract (PRSE) administration on the lifespan of Caenorhabditis elegans. C. elegans worms were subjected to a diet containing PRSE powder at various larval stages until their death. The optimal concentration for lifespan extension was found to be 5 mg/mL PRSE, which increased the lifespan of N2 worms by 18.12% compared to the control group. Mutant strains were also tested, and worm thermotolerance assays were used to assess age-related health at different life stages. Lifespan was notably extended when PRSE was introduced at the first larval stage and 15 h thereafter. No significant extension of lifespan was observed when introduced later in life. The lifespan of DAF-16 and DAF-2 mutants remained unaffected by PRSE. Improved thermotolerance was observed, especially in young and middle-aged worms. Early initiation and sustained intake of PRSE might improve the heat stress and lifespan, implicating the insulin/IGF-1 signaling pathway as a likely mediator in C. elegans.","PeriodicalId":73588,"journal":{"name":"Journal of ageing and longevity","volume":"42 21","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140431517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: The purpose of this study was to investigate the health and wellness benefits of dog companionship in a population of women over 50 years old. Methods: This study used a combination of an online survey (n = 284 self-identified dog companions, n = 71 non-dog companions) and in-person fitness testing (n = 24 dog companions and n = 7 non-dog companions). In-person testing included the 6 min walk, handgrip strength, and chair stand tests. Results: From the questionnaire: Dog companions were 61 ± 7 years old and non-dog companions were 58 ± 6 years old. Dog companions reported 3 ± 2 medical diagnoses and 2 ± 1 medications, but non-dog companions only reported 2 ± 1 medical diagnoses and 1 ± 1 medications (p < 0.001). Satisfaction with life scores and interpersonal communication competence scores were higher for dog companions compared to non-dog companions (p < 0.001). Dog companions and non-dog companions reported similar amounts of time per week on vigorous activity. However, the number of days per week in which dog companions participated in moderate activity was higher than in non-dog companions (p < 0.05). Dog companions also reported walking more days per week and for a longer time than non-dog companions (p < 0.05). There were no differences in the in-person testing (6 min walk, handgrip strength, chair stand tests) between groups. Conclusions: When the in-person testing scores were compared to national standards, the women in this study were average to above average. Overall, women over 50 that own dogs walk more and have better life satisfaction, compared to non-dog companions.
{"title":"Health and Benefits of Dog Companionship in Women over 50 Years Old","authors":"Heidi A. Kluess, Rebecca L. Jones","doi":"10.3390/jal4010001","DOIUrl":"https://doi.org/10.3390/jal4010001","url":null,"abstract":"Background: The purpose of this study was to investigate the health and wellness benefits of dog companionship in a population of women over 50 years old. Methods: This study used a combination of an online survey (n = 284 self-identified dog companions, n = 71 non-dog companions) and in-person fitness testing (n = 24 dog companions and n = 7 non-dog companions). In-person testing included the 6 min walk, handgrip strength, and chair stand tests. Results: From the questionnaire: Dog companions were 61 ± 7 years old and non-dog companions were 58 ± 6 years old. Dog companions reported 3 ± 2 medical diagnoses and 2 ± 1 medications, but non-dog companions only reported 2 ± 1 medical diagnoses and 1 ± 1 medications (p < 0.001). Satisfaction with life scores and interpersonal communication competence scores were higher for dog companions compared to non-dog companions (p < 0.001). Dog companions and non-dog companions reported similar amounts of time per week on vigorous activity. However, the number of days per week in which dog companions participated in moderate activity was higher than in non-dog companions (p < 0.05). Dog companions also reported walking more days per week and for a longer time than non-dog companions (p < 0.05). There were no differences in the in-person testing (6 min walk, handgrip strength, chair stand tests) between groups. Conclusions: When the in-person testing scores were compared to national standards, the women in this study were average to above average. Overall, women over 50 that own dogs walk more and have better life satisfaction, compared to non-dog companions.","PeriodicalId":73588,"journal":{"name":"Journal of ageing and longevity","volume":"27 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139598337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The global incidence of dementia has been rising for the past several years, posing significant health challenges regarding its management and prevention. Dementia is associated with a substantial burden on patients and their families. Therefore, effective, evidence-based preventive strategies are required for dementia. To achieve this, the predisposing factors for dementia and their relationship with other diseases need to be determined. Japan has a universal health insurance system and these data have been stored in their respective databases since 2008. Herein we explored the influence of clinical history on the occurrence of dementia based on data collected by the National Health Insurance in Japan and Municipal Care Certification Survey over the past 10 years. Multivariate logistic regression analysis was used to determine the factors from clinical history that affect the risk of dementia development. A significant odds ratio was observed for the development of dementia in 5-year data, involving the clinical history of osteoporosis, depression, internal carotid artery occlusion, schizophrenia, and Parkinson’s disease. In addition, a significant odds ratio was observed for the development of dementia in 10-year data, involving the clinical history of osteoporosis, cataracts, and schizophrenia.
{"title":"Evaluation of the Influence of Clinical History on the Occurrence of Dementia Using the Database of National Health Insurance in Japan","authors":"Y. Tamaki, Y. Hiratsuka, T. Kumakawa","doi":"10.3390/jal3040025","DOIUrl":"https://doi.org/10.3390/jal3040025","url":null,"abstract":"The global incidence of dementia has been rising for the past several years, posing significant health challenges regarding its management and prevention. Dementia is associated with a substantial burden on patients and their families. Therefore, effective, evidence-based preventive strategies are required for dementia. To achieve this, the predisposing factors for dementia and their relationship with other diseases need to be determined. Japan has a universal health insurance system and these data have been stored in their respective databases since 2008. Herein we explored the influence of clinical history on the occurrence of dementia based on data collected by the National Health Insurance in Japan and Municipal Care Certification Survey over the past 10 years. Multivariate logistic regression analysis was used to determine the factors from clinical history that affect the risk of dementia development. A significant odds ratio was observed for the development of dementia in 5-year data, involving the clinical history of osteoporosis, depression, internal carotid artery occlusion, schizophrenia, and Parkinson’s disease. In addition, a significant odds ratio was observed for the development of dementia in 10-year data, involving the clinical history of osteoporosis, cataracts, and schizophrenia.","PeriodicalId":73588,"journal":{"name":"Journal of ageing and longevity","volume":"54 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138595286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chloé Da Silva Coelho, A. Hering, S. Zuber, Giulia Spurio, P. Bisiacchi, Matthias Kliegel
Prospective memory (PM) plays a crucial role in daily autonomy. Metamemory and emotional valence have both been shown to influence PM performance in younger and older adults. However, when considered together, the relationship between emotional valence, metamemory, and PM has not been examined yet, especially whether metamemory PM representations develop with task experience (i.e., before versus after performing a task). We collected data from 25 younger and 19 older adults using an event-based PM task with emotional cues (positive, negative, or neutral). Results revealed that younger adults’ predictions underestimated performance for neutral and negative cues. After performing the task, they showed more accurate representations for neutral cues, indicating that they monitored their representations. Older adults’ predictions overestimated performance for negative PM cues, and they did not modify representations after performing the task. Thus, we do not find evidence that older adults are able to coherently monitor their PM representations. These findings highlight the importance of understanding PM representations, especially in older adults, as they may lead to less strategy use and more impaired PM performance in negative everyday situations.
{"title":"Exploring the Relationship between Emotional Valence and Prospective Memory Metamemory in Younger and Older Adults","authors":"Chloé Da Silva Coelho, A. Hering, S. Zuber, Giulia Spurio, P. Bisiacchi, Matthias Kliegel","doi":"10.3390/jal3040024","DOIUrl":"https://doi.org/10.3390/jal3040024","url":null,"abstract":"Prospective memory (PM) plays a crucial role in daily autonomy. Metamemory and emotional valence have both been shown to influence PM performance in younger and older adults. However, when considered together, the relationship between emotional valence, metamemory, and PM has not been examined yet, especially whether metamemory PM representations develop with task experience (i.e., before versus after performing a task). We collected data from 25 younger and 19 older adults using an event-based PM task with emotional cues (positive, negative, or neutral). Results revealed that younger adults’ predictions underestimated performance for neutral and negative cues. After performing the task, they showed more accurate representations for neutral cues, indicating that they monitored their representations. Older adults’ predictions overestimated performance for negative PM cues, and they did not modify representations after performing the task. Thus, we do not find evidence that older adults are able to coherently monitor their PM representations. These findings highlight the importance of understanding PM representations, especially in older adults, as they may lead to less strategy use and more impaired PM performance in negative everyday situations.","PeriodicalId":73588,"journal":{"name":"Journal of ageing and longevity","volume":"131 21","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138599146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
We are happy that the Journal of Ageing and Longevity has now entered its third year, publishing notable papers covering the wide field encompassed by its title [...]
{"title":"The Updated Scope of the Journal of Ageing and Longevity","authors":"Graham P. Pawelec, Mark A. Tully","doi":"10.3390/jal3040023","DOIUrl":"https://doi.org/10.3390/jal3040023","url":null,"abstract":"We are happy that the Journal of Ageing and Longevity has now entered its third year, publishing notable papers covering the wide field encompassed by its title [...]","PeriodicalId":73588,"journal":{"name":"Journal of ageing and longevity","volume":"140 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139247975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ester Lopes de Melo, Bruno Augusto Machado Tavares, Nayara Nílcia Dias Colares, Aline Lopes do Nascimento, H. Carvalho, Andrés Navarrete Castro, Arlindo César Matias Pereira, Carlos Eduardo Winter, I. D. S. Sena, Luiz Fernando Moreira, J. C. T. Carvalho
Aging is a complex process associated with tissue degeneration and an increased risk of age-related diseases. This study aimed to evaluate the impact of Terasen®, a nutraceutical containing standardized extracts of Euterpe oleracea, Myrciaria dubia, and purified oil of Bixa orellana and Astrocaryum aculeatum on the lifespan of Caenorhabditis elegans. The findings demonstrated that Terasen® exhibited significant radical scavenging in vitro, decreased the feeding behavior of C. elegans without affecting the animals’ final size, increased the eggs laid in a concentration-dependent fashion, although the total progeny was reduced compared to the control, and increased the median and maximum lifespan. These findings suggest that Terasen® may improve the lifespan in C. elegans, warranting further investigation.
{"title":"Association of Euterpe oleracea, Bixa orellana, Myciaria dubia, and Astrocaryum aculeatum (the Terasen® Nutraceutical) Increases the Lifespan of Caenorhabditis elegans","authors":"Ester Lopes de Melo, Bruno Augusto Machado Tavares, Nayara Nílcia Dias Colares, Aline Lopes do Nascimento, H. Carvalho, Andrés Navarrete Castro, Arlindo César Matias Pereira, Carlos Eduardo Winter, I. D. S. Sena, Luiz Fernando Moreira, J. C. T. Carvalho","doi":"10.3390/jal3040022","DOIUrl":"https://doi.org/10.3390/jal3040022","url":null,"abstract":"Aging is a complex process associated with tissue degeneration and an increased risk of age-related diseases. This study aimed to evaluate the impact of Terasen®, a nutraceutical containing standardized extracts of Euterpe oleracea, Myrciaria dubia, and purified oil of Bixa orellana and Astrocaryum aculeatum on the lifespan of Caenorhabditis elegans. The findings demonstrated that Terasen® exhibited significant radical scavenging in vitro, decreased the feeding behavior of C. elegans without affecting the animals’ final size, increased the eggs laid in a concentration-dependent fashion, although the total progeny was reduced compared to the control, and increased the median and maximum lifespan. These findings suggest that Terasen® may improve the lifespan in C. elegans, warranting further investigation.","PeriodicalId":73588,"journal":{"name":"Journal of ageing and longevity","volume":"81 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139267798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The current study will explore the post-pandemic bereavement window of widowed caregivers who experienced higher degrees of social isolation and the ways in which leisure was used to cope. A phenomenological multi-case study technique was used to explore the “multiple realities” among female caregivers whose social convoys suffered pre-pandemic because of spousal caregiving and were further impacted by COVID-19 mitigation strategies during the pandemic. Initial analyses utilized the two-cycle approach, as defined by Saldana. In the initial cycle, the researchers independently immersed themselves in the raw data gathered during participant interviews and engaged in open coding to discern concepts, patterns, themes, and categories associated with the multiple realities among the widows whose leisure participation was affected due to the strain of spousal caregiving and exacerbated by COVID-19 mitigation strategies. After completing the first cycle, the researchers then moved to the second phase, thematic analysis, which sought to develop a more structured framework by which to understand the data by identifying, analyzing, and reporting patterns (e.g., themes) within it. A qualitative comparison technique was then employed to deepen our understanding of individuals’ lived experiences. Thematic findings revealed three areas of similarities: Social isolation from caregiving, using leisure to self-focus and explore future possibilities, and core groups.
{"title":"Examining the Role of Leisure in Navigating Spousal Death: A Phenomenological Multi-Case Study of Widowhood","authors":"Thomas P. Sweeney, Jennifer Zorotovich","doi":"10.3390/jal3040021","DOIUrl":"https://doi.org/10.3390/jal3040021","url":null,"abstract":"The current study will explore the post-pandemic bereavement window of widowed caregivers who experienced higher degrees of social isolation and the ways in which leisure was used to cope. A phenomenological multi-case study technique was used to explore the “multiple realities” among female caregivers whose social convoys suffered pre-pandemic because of spousal caregiving and were further impacted by COVID-19 mitigation strategies during the pandemic. Initial analyses utilized the two-cycle approach, as defined by Saldana. In the initial cycle, the researchers independently immersed themselves in the raw data gathered during participant interviews and engaged in open coding to discern concepts, patterns, themes, and categories associated with the multiple realities among the widows whose leisure participation was affected due to the strain of spousal caregiving and exacerbated by COVID-19 mitigation strategies. After completing the first cycle, the researchers then moved to the second phase, thematic analysis, which sought to develop a more structured framework by which to understand the data by identifying, analyzing, and reporting patterns (e.g., themes) within it. A qualitative comparison technique was then employed to deepen our understanding of individuals’ lived experiences. Thematic findings revealed three areas of similarities: Social isolation from caregiving, using leisure to self-focus and explore future possibilities, and core groups.","PeriodicalId":73588,"journal":{"name":"Journal of ageing and longevity","volume":"121 25","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136351747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-05DOI: 10.47855/jal9020-2023-3-3
Olena Tomarevska, Oleksandr Poliakov
For a general health assessment of the workers in organized industries, and unorganized groups of the unemployed and retirees, systematic online health monitoring has been used. Health monitoring includes a scale assessment of functional tests. The actual state of population health is still not included in the registers of National Statistics of Ukraine for example workers, pensioners and unemployment. The purpose of the study was systemic online health monitoring, to assess the impact of professional, demographic, and socio-economic factors in the Covid-19 pandemic condition and the limited capacity of the health care system in Ukraine. Methods: The study used the intrinsic capacity assessment scales, the five-question scale to detect muscle dysfunction in older persons, as well as some questions regarding residual performance, psychophysiological methods, and characteristics of the functional age. The questionnaire Human Health Passport 1.1 includes 70 questions; 21 of them were assessed by 1 point for positive answer and zero for negative case. The screening was carried out online on social media to Internet users aged 31 to 90. In the study 377 respondents of which 83.83% were employees. The Human Health Passport screening showed reliability (Cronbach alfa = 0.737), and correlation relationships of the main estimated indicators are significant. So, 54% of respondents do need health care under a physician’s supervision. The 39% of respondents need should convey the proper individual schedule of workout and labour hours, as well as physical activity and breathing exercises because only 7% of respondents are healthy. Correlation analysis of the scale results showed a significant relationship between age, with static balancing, falls during the last 6 months, and the ability to 5 times sit to stand test within 14 seconds. The optimal management of Human Health Passport screening helps to reduce the harmful influence on the environment, and transport expenses for doctor visits and saves the doctor's time for patient examination and prevention of the exposure and the spread of COVID-19. The screening showed the existing reserves of training for health promotion and, the overstrain of the functional systems of the body in the working population - 76%—by the purpose. _________________________________________________________________________________________ Keywords: remote health screening; retirees; biological age; ageing; elderly workers
{"title":"The Health and Functional Age Trend Self-assessment of the Older Workers and Retirees in Ukraine from Online Data Human Health Passport in COVID-19 Pandemic","authors":"Olena Tomarevska, Oleksandr Poliakov","doi":"10.47855/jal9020-2023-3-3","DOIUrl":"https://doi.org/10.47855/jal9020-2023-3-3","url":null,"abstract":"For a general health assessment of the workers in organized industries, and unorganized groups of the unemployed and retirees, systematic online health monitoring has been used. Health monitoring includes a scale assessment of functional tests. The actual state of population health is still not included in the registers of National Statistics of Ukraine for example workers, pensioners and unemployment. The purpose of the study was systemic online health monitoring, to assess the impact of professional, demographic, and socio-economic factors in the Covid-19 pandemic condition and the limited capacity of the health care system in Ukraine. Methods: The study used the intrinsic capacity assessment scales, the five-question scale to detect muscle dysfunction in older persons, as well as some questions regarding residual performance, psychophysiological methods, and characteristics of the functional age. The questionnaire Human Health Passport 1.1 includes 70 questions; 21 of them were assessed by 1 point for positive answer and zero for negative case. The screening was carried out online on social media to Internet users aged 31 to 90. In the study 377 respondents of which 83.83% were employees. The Human Health Passport screening showed reliability (Cronbach alfa = 0.737), and correlation relationships of the main estimated indicators are significant. So, 54% of respondents do need health care under a physician’s supervision. The 39% of respondents need should convey the proper individual schedule of workout and labour hours, as well as physical activity and breathing exercises because only 7% of respondents are healthy. Correlation analysis of the scale results showed a significant relationship between age, with static balancing, falls during the last 6 months, and the ability to 5 times sit to stand test within 14 seconds. The optimal management of Human Health Passport screening helps to reduce the harmful influence on the environment, and transport expenses for doctor visits and saves the doctor's time for patient examination and prevention of the exposure and the spread of COVID-19. The screening showed the existing reserves of training for health promotion and, the overstrain of the functional systems of the body in the working population - 76%—by the purpose. _________________________________________________________________________________________ Keywords: remote health screening; retirees; biological age; ageing; elderly workers","PeriodicalId":73588,"journal":{"name":"Journal of ageing and longevity","volume":"94 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135724413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-01DOI: 10.47855/jal9020-2023-3-2
Vitalii Kyryk, Alina Ustymenko, Oleg Tsupykov
The review analyses modern scientific research on the impact of adipose tissue dysfunction associated with ageing on the morphofunctional characteristics of adipose-derived stem cells. Ageing in the body is accompanied by dysfunction in all tissues and organs, including adipose tissue, where changes in stem cells and their niche are associated with chronic systemic inflammation and metabolic disorders. Changes in stem cells induced by ageing-associated pathologies can affect both the effectiveness of endogenous tissue repair and the functional characteristics of the cell product. Increased production of pro-inflammatory cytokines and a decrease in the production of anti-inflammatory mediators and growth factors, accompanied by enhanced cellular infiltration, characterised as a senescence-associated secretory phenotype (SASP). SASP impact the potential of adipose-derived stem cells for proliferation, differentiation, signalling and even inducing apoptosis in recipient tissue after transplantation. The establishing characteristics of senescent cell cultures will provide new insights into the mechanisms of ageing and identify promising directions for its correction, including the clinical application of cell technologies. Special attention should be given to developing new approaches to assessing not only the quality and safety of cell products but also the functional state of niches in the recipient's body, which will represent a new strategy in personalized regenerative medicine. _________________________________________________________________________________________ Keywords: adipose-derived stem cells; multipotent mesenchymal stromal cells; cell differentiation; cell therapy; ageing
{"title":"The effect of ageing on the properties of adipose-derived stem cells. Literature review","authors":"Vitalii Kyryk, Alina Ustymenko, Oleg Tsupykov","doi":"10.47855/jal9020-2023-3-2","DOIUrl":"https://doi.org/10.47855/jal9020-2023-3-2","url":null,"abstract":"The review analyses modern scientific research on the impact of adipose tissue dysfunction associated with ageing on the morphofunctional characteristics of adipose-derived stem cells. Ageing in the body is accompanied by dysfunction in all tissues and organs, including adipose tissue, where changes in stem cells and their niche are associated with chronic systemic inflammation and metabolic disorders. Changes in stem cells induced by ageing-associated pathologies can affect both the effectiveness of endogenous tissue repair and the functional characteristics of the cell product. Increased production of pro-inflammatory cytokines and a decrease in the production of anti-inflammatory mediators and growth factors, accompanied by enhanced cellular infiltration, characterised as a senescence-associated secretory phenotype (SASP). SASP impact the potential of adipose-derived stem cells for proliferation, differentiation, signalling and even inducing apoptosis in recipient tissue after transplantation. The establishing characteristics of senescent cell cultures will provide new insights into the mechanisms of ageing and identify promising directions for its correction, including the clinical application of cell technologies. Special attention should be given to developing new approaches to assessing not only the quality and safety of cell products but also the functional state of niches in the recipient's body, which will represent a new strategy in personalized regenerative medicine. _________________________________________________________________________________________ Keywords: adipose-derived stem cells; multipotent mesenchymal stromal cells; cell differentiation; cell therapy; ageing","PeriodicalId":73588,"journal":{"name":"Journal of ageing and longevity","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135220992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Amy Beardmore, Penny Beynon, Christine Crabbe, Jan Fullforth, Jeremy Groome, Matthew Jones
Background: Whilst qualitative research has previously been conducted on older people’s personal resilience and wellbeing during COVID-19, there are fewer empirical studies on the impact it had on social connectedness for this age group. In this paper we seek to examine older people’s social connectedness to others during the pandemic, their personal experiences of seeking out those connections, and whether there are any identifiable pre-existing factors that enabled them to minimise the impact of enforced isolation. Methods: Using a phenomenological methodology, we conducted in-depth interviews with 13 older people between March and May 2021. These interviews explored the participant’s lived experiences of staying socially connected to others during the enforced lockdowns and various restrictions. Results: Our findings reveal strong themes of personal resilience, sense of coherence and other protective factors, but also highlight the benefits of establishing connections to friends, family, organised groups and community prior to the pandemic. Conclusion: Older people’s ability to stay socially connected is influenced by personal resilience and a positive mindset; pre-existing social ties to others and maintaining a personal sense of coherence and a sense of belonging to people or places. Our findings shed light on the importance of informal social interactions, what it means to feel lonely in older age and indicate that for some the pandemic restrictions may even have offered a welcome space in which to process significant life events.
{"title":"Social Connectedness in a Locked-Down World: A Phenomenological Study of Older Adults during the COVID-19 Pandemic","authors":"Amy Beardmore, Penny Beynon, Christine Crabbe, Jan Fullforth, Jeremy Groome, Matthew Jones","doi":"10.3390/jal3040020","DOIUrl":"https://doi.org/10.3390/jal3040020","url":null,"abstract":"Background: Whilst qualitative research has previously been conducted on older people’s personal resilience and wellbeing during COVID-19, there are fewer empirical studies on the impact it had on social connectedness for this age group. In this paper we seek to examine older people’s social connectedness to others during the pandemic, their personal experiences of seeking out those connections, and whether there are any identifiable pre-existing factors that enabled them to minimise the impact of enforced isolation. Methods: Using a phenomenological methodology, we conducted in-depth interviews with 13 older people between March and May 2021. These interviews explored the participant’s lived experiences of staying socially connected to others during the enforced lockdowns and various restrictions. Results: Our findings reveal strong themes of personal resilience, sense of coherence and other protective factors, but also highlight the benefits of establishing connections to friends, family, organised groups and community prior to the pandemic. Conclusion: Older people’s ability to stay socially connected is influenced by personal resilience and a positive mindset; pre-existing social ties to others and maintaining a personal sense of coherence and a sense of belonging to people or places. Our findings shed light on the importance of informal social interactions, what it means to feel lonely in older age and indicate that for some the pandemic restrictions may even have offered a welcome space in which to process significant life events.","PeriodicalId":73588,"journal":{"name":"Journal of ageing and longevity","volume":"21 5","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135265754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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