Although evidence-based programs have been effective for fall prevention in many communities, older adults living in underserved areas cannot access these services due to the shortage of providers and trainers. In this cross-sectional study, a multi-agency approach was adopted for integrating an evidence-based program, A Matter of Balance (AMOB), into the public health curriculum at a rurally placed university. We assessed student learning as well as the community benefits of fall prevention among those who participated in the AMOB program. Eighty-four percent of the students reported intentions of using AMOB training in their future careers. The average of the items for the effectiveness of “Classroom Training” and “Community Training” provided by the students (n = 25) ranged from 3.52 to 4.32 and 3.48 to 4.36, on a Likert scale (1 = Strongly Disagree to 5 = Strongly Agree), respectively. Older adults who participated in the fall prevention community workshops showed increased confidence in reducing falls, protecting themselves from falling, and becoming steadier on their feet after the training (p < 0.05). Our study demonstrates the value of integrating evidence-based programs such as AMOB in a university curriculum to address rural health disparities related to falls.
尽管基于证据的项目在许多社区预防跌倒方面很有效，但由于缺乏提供者和培训人员，生活在服务不足地区的老年人无法获得这些服务。在这项横断面研究中，采用多机构方法将基于证据的项目“平衡问题”(a Matter of Balance, AMOB)纳入一所农村大学的公共卫生课程。我们评估了参加AMOB项目的学生的学习情况以及预防跌倒的社区效益。84%的学生表示，他们打算在未来的职业生涯中使用AMOB培训。学生(n = 25)提供的“课堂培训”和“社区培训”有效性项目的平均值在李克特量表(1 =非常不同意到5 =非常同意)上分别为3.52至4.32和3.48至4.36。参加预防跌倒社区研讨会的老年人在减少跌倒、保护自己不跌倒和训练后变得更稳定方面表现出更大的信心(p <0.05)。我们的研究证明了在大学课程中整合AMOB等循证项目的价值，以解决与跌倒相关的农村健康差异。
{"title":"Empowering Older Adults in Underserved Communities—An Innovative Approach to Increase Public Health Capacity for Fall Prevention","authors":"Subi Gandhi, Laurie Long, Viraj Gandhi, Muna Bashir","doi":"10.3390/jal3040019","DOIUrl":"https://doi.org/10.3390/jal3040019","url":null,"abstract":"Although evidence-based programs have been effective for fall prevention in many communities, older adults living in underserved areas cannot access these services due to the shortage of providers and trainers. In this cross-sectional study, a multi-agency approach was adopted for integrating an evidence-based program, A Matter of Balance (AMOB), into the public health curriculum at a rurally placed university. We assessed student learning as well as the community benefits of fall prevention among those who participated in the AMOB program. Eighty-four percent of the students reported intentions of using AMOB training in their future careers. The average of the items for the effectiveness of “Classroom Training” and “Community Training” provided by the students (n = 25) ranged from 3.52 to 4.32 and 3.48 to 4.36, on a Likert scale (1 = Strongly Disagree to 5 = Strongly Agree), respectively. Older adults who participated in the fall prevention community workshops showed increased confidence in reducing falls, protecting themselves from falling, and becoming steadier on their feet after the training (p < 0.05). Our study demonstrates the value of integrating evidence-based programs such as AMOB in a university curriculum to address rural health disparities related to falls.","PeriodicalId":73588,"journal":{"name":"Journal of ageing and longevity","volume":"63 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135094297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract. This study aims to investigate changes in heart rate variability (HRV) in women with PTSD during the Russian-Ukrainian war, in 2023. The study included 16 women with PTSD (age 49.60 ± 1.46 years) and 31 women (control, age 52.10 ± 1.27 years) aged from 30 to 69 years old, who were examined. Blood pressure, heart rate and ECG measurements were taken in the supine positions (within 5 minutes). HRV scores were calculated in the time domain and frequency domain. In women with PTSD, there was significantly lower control in the values of SDNN and TP values, which characterize the total power of neurohumoral regulation of heart rate (p< 0.05). The baroreflex activity, assessed by the spectral power of low-frequency waves (LF), in women with PTSD did not change significantly compared to controls. The differences in the indicators characterizing vagal influences were especially pronounced: in women with PTSD, RMSSD, pNN50 and HF component of HRV were lower than in controls. The sympathovagal balance (LF/HF) in women with PTSD, compared with the control, is shifted towards the predominance of sympathetic activity. The average BA in the group of people with PTSD was 57.30±1.32 years and in the control group – 55.65 ± 0.97 years. The difference between BA and CA is 7.72±1.42 years in the women with PTSD and 3.55 ± 1.06 in the control group (p< 0.05). From this, we can conclude that PTSD can be a factor in accelerating ageing. The data obtained in our study allow us to conclude that PTSD may be a factor that disrupts autonomic regulation and accelerates ageing. _________________________________________________________________________________________ Keywords: heart rate variability, posttraumatic stress disorder, Ukraine 2023.
{"title":"Heart Rate Variability and Aging Rate in Women with Post-Traumatic Stress Disorder during Russian-Ukrainian War, 2023","authors":"Anatoly Pisaruk, Ivanna Antoniuk-Shcheglova, Ludmila Mekhova, Svitlana Naskalova, Valeri Shatilo","doi":"10.47855/jal9020-2023-3-1","DOIUrl":"https://doi.org/10.47855/jal9020-2023-3-1","url":null,"abstract":"Abstract. This study aims to investigate changes in heart rate variability (HRV) in women with PTSD during the Russian-Ukrainian war, in 2023. The study included 16 women with PTSD (age 49.60 ± 1.46 years) and 31 women (control, age 52.10 ± 1.27 years) aged from 30 to 69 years old, who were examined. Blood pressure, heart rate and ECG measurements were taken in the supine positions (within 5 minutes). HRV scores were calculated in the time domain and frequency domain. In women with PTSD, there was significantly lower control in the values of SDNN and TP values, which characterize the total power of neurohumoral regulation of heart rate (p< 0.05). The baroreflex activity, assessed by the spectral power of low-frequency waves (LF), in women with PTSD did not change significantly compared to controls. The differences in the indicators characterizing vagal influences were especially pronounced: in women with PTSD, RMSSD, pNN50 and HF component of HRV were lower than in controls. The sympathovagal balance (LF/HF) in women with PTSD, compared with the control, is shifted towards the predominance of sympathetic activity. The average BA in the group of people with PTSD was 57.30±1.32 years and in the control group – 55.65 ± 0.97 years. The difference between BA and CA is 7.72±1.42 years in the women with PTSD and 3.55 ± 1.06 in the control group (p< 0.05). From this, we can conclude that PTSD can be a factor in accelerating ageing. The data obtained in our study allow us to conclude that PTSD may be a factor that disrupts autonomic regulation and accelerates ageing. _________________________________________________________________________________________ Keywords: heart rate variability, posttraumatic stress disorder, Ukraine 2023.","PeriodicalId":73588,"journal":{"name":"Journal of ageing and longevity","volume":"48 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135815190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The global population has been gradually aging over the past few decades, with a growing proportion of people aged 65 years or older. Simultaneously, the medical profession has shifted towards promoting the concept of “positive” gerontology, emphasizing healthy aging. In this context, we investigated the trends in pathological specimen submissions from patients aged 85 or older over ten years at a single center. We observed a nearly two-fold increase in submissions during 2015–2019 compared to 2010–2014, out of proportion to the change in the fraction of older adults in the population, suggesting a changing attitude towards medical care in these older patients. Dermatologic samples were the main driver of growth, followed by gastrointestinal and urinary tract samples. However, other samples, like breast and lung, did not significantly increase. Although further research is needed to understand the implications of increasing invasive procedures in the oldest old, a noteworthy trend has emerged towards increased and more active healthcare for this population. Healthcare providers and administrators should be prepared for a continued rise in invasive interventions in this age group.
{"title":"Trends in Octogenarian Pathology","authors":"Tal Keidar Haran, Arnon Haran, N. Pillar","doi":"10.3390/jal3030018","DOIUrl":"https://doi.org/10.3390/jal3030018","url":null,"abstract":"The global population has been gradually aging over the past few decades, with a growing proportion of people aged 65 years or older. Simultaneously, the medical profession has shifted towards promoting the concept of “positive” gerontology, emphasizing healthy aging. In this context, we investigated the trends in pathological specimen submissions from patients aged 85 or older over ten years at a single center. We observed a nearly two-fold increase in submissions during 2015–2019 compared to 2010–2014, out of proportion to the change in the fraction of older adults in the population, suggesting a changing attitude towards medical care in these older patients. Dermatologic samples were the main driver of growth, followed by gastrointestinal and urinary tract samples. However, other samples, like breast and lung, did not significantly increase. Although further research is needed to understand the implications of increasing invasive procedures in the oldest old, a noteworthy trend has emerged towards increased and more active healthcare for this population. Healthcare providers and administrators should be prepared for a continued rise in invasive interventions in this age group.","PeriodicalId":73588,"journal":{"name":"Journal of ageing and longevity","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47559477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mahsa Sadatnia, Amir Jalali, Laili Tapak, F. Shamsaei
Background and Aim: The coronavirus pandemic has had a negative impact on the health and well-being of communities and individuals around the world. One of the concerns about the COVID-19 epidemic is the impact of social isolation due to social distancing on the mental health of older adults. This study aimed to investigate the relationship between mental health and loneliness among seniors during the COVID-19 pandemic. Materials and Methods: In this cross-sectional study, 211 retirees of Kermanshah University of Medical Sciences were selected by available sampling method in 2021. Data were collected through the Demographic, Mental Health Questionnaire (GHQ-28) and the Adult Social and Emotional Feeling Questionnaire (SELSA-S). Data were analyzed using paired t-test, one-way analysis of variance, covariance, and chi-squared tests. The significance level was considered 0.05. Results: The mean age of participants was 71.26 years and the results showed a significant relationship between feeling lonely and mental health (r = 0.535, p = 0.001). There were statistically significant relationships between mental health and social functioning (r = −0.204, p ≥ 0.001) and depression (r = 0.501, p = 0.001) and also between mental health and three subscales of loneliness: romantic loneliness (r = 0.001, p = 0.001), social loneliness (r = 0.493, p = 0.001), and family loneliness (r = 0.289, p = 0.001). Conclusion: Feeling lonely during the coronavirus disease pandemic has a negative effect on the mental health of older adults; therefore, it is necessary for mental health professionals to improve the mental health of the elderly with proper planning and interventions.
{"title":"The Relationship between Mental Health and Loneliness in the Elderly during the COVID-19 Pandemic","authors":"Mahsa Sadatnia, Amir Jalali, Laili Tapak, F. Shamsaei","doi":"10.3390/jal3030017","DOIUrl":"https://doi.org/10.3390/jal3030017","url":null,"abstract":"Background and Aim: The coronavirus pandemic has had a negative impact on the health and well-being of communities and individuals around the world. One of the concerns about the COVID-19 epidemic is the impact of social isolation due to social distancing on the mental health of older adults. This study aimed to investigate the relationship between mental health and loneliness among seniors during the COVID-19 pandemic. Materials and Methods: In this cross-sectional study, 211 retirees of Kermanshah University of Medical Sciences were selected by available sampling method in 2021. Data were collected through the Demographic, Mental Health Questionnaire (GHQ-28) and the Adult Social and Emotional Feeling Questionnaire (SELSA-S). Data were analyzed using paired t-test, one-way analysis of variance, covariance, and chi-squared tests. The significance level was considered 0.05. Results: The mean age of participants was 71.26 years and the results showed a significant relationship between feeling lonely and mental health (r = 0.535, p = 0.001). There were statistically significant relationships between mental health and social functioning (r = −0.204, p ≥ 0.001) and depression (r = 0.501, p = 0.001) and also between mental health and three subscales of loneliness: romantic loneliness (r = 0.001, p = 0.001), social loneliness (r = 0.493, p = 0.001), and family loneliness (r = 0.289, p = 0.001). Conclusion: Feeling lonely during the coronavirus disease pandemic has a negative effect on the mental health of older adults; therefore, it is necessary for mental health professionals to improve the mental health of the elderly with proper planning and interventions.","PeriodicalId":73588,"journal":{"name":"Journal of ageing and longevity","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47253859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This paper is dedicated to the research presented at the 26th Nordic Congress of Gerontology in Odense, Denmark, in June 2022, which was organized by the Danish Gerontological Society and the Danish Society for Geriatrics. The overall topics of the congress were change and continuity. Participants were invited to explore questions on change and continuity from the perspective of ageing and later life within the following congress themes: digitisation and technology; housing, generations and mobility; lifestyle, engagement and transition; education and competences in ageing societies; morbidity, medical treatment and ageing processes; and a good life and a good death. Life is about change and continuity. We experience ourselves and our surroundings differently throughout our lives. For most people, later life is characterized by major transitions, moving towards frailty and multiple losses. But it may also be a part of life with more time to engage in preferred activities, explore new possibilities, and to cope and come to terms with new challenges. The COVID-19 pandemic proved to be a challenge to the world beyond imagination, particularly for frail and vulnerable people and societies. However, it also provided valuable new insights and reminded us of the values in life. We, therefore, also welcomed presentations and discussions on societal perspectives such as citizen perspective, ethnicity, inequality, sustainability and ecology, the pandemic and lockdown. We thank the organizers, scientific committees and all participants for a great congress with high-quality presentations and discussions.
{"title":"Abstracts from the 26th Nordic Congress of Gerontology","authors":"J. Thuesen, C. Nilsson, P. Caserotti","doi":"10.3390/jal3030016","DOIUrl":"https://doi.org/10.3390/jal3030016","url":null,"abstract":"This paper is dedicated to the research presented at the 26th Nordic Congress of Gerontology in Odense, Denmark, in June 2022, which was organized by the Danish Gerontological Society and the Danish Society for Geriatrics. The overall topics of the congress were change and continuity. Participants were invited to explore questions on change and continuity from the perspective of ageing and later life within the following congress themes: digitisation and technology; housing, generations and mobility; lifestyle, engagement and transition; education and competences in ageing societies; morbidity, medical treatment and ageing processes; and a good life and a good death. Life is about change and continuity. We experience ourselves and our surroundings differently throughout our lives. For most people, later life is characterized by major transitions, moving towards frailty and multiple losses. But it may also be a part of life with more time to engage in preferred activities, explore new possibilities, and to cope and come to terms with new challenges. The COVID-19 pandemic proved to be a challenge to the world beyond imagination, particularly for frail and vulnerable people and societies. However, it also provided valuable new insights and reminded us of the values in life. We, therefore, also welcomed presentations and discussions on societal perspectives such as citizen perspective, ethnicity, inequality, sustainability and ecology, the pandemic and lockdown. We thank the organizers, scientific committees and all participants for a great congress with high-quality presentations and discussions.","PeriodicalId":73588,"journal":{"name":"Journal of ageing and longevity","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48934687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Lima, M. T. Moreira, M. S. Ferreira, V. Parola, F. Sampaio, M. D. P. Nóbrega, C. Fernandes
Background: Scientific and technological advancements have significantly impacted our daily lives, and it is not easy to imagine living without their benefits. However, elderly individuals may experience limited access to these resources, impeding their autonomy. To address this, the use of exergames has been proposed to promote the mental health and socialization of older people. This study aims to systematically review the effectiveness of exergames in promoting older people’s mental health and socialization. Methods: The Joanna Briggs Institute’s recommended methodology will be used for a systematic review. Databases relevant to the research topic, such as those regarding gerontologic care, aged rehabilitation, geriatric games, video games, play and playthings, mental health, anxiety, depression, stress, and physiological factors, will be searched for experimental and quasi-experimental studies, as well as randomized studies with and without control groups. Results: The systematic literature review will synthesize findings on the effectiveness of exergames in promoting mental health and socialization in the elderly population. Conclusions: Exergames may have the potential to effectively improve the mental health and socialization of the elderly population. Identifying which exergames are most effective for these purposes is important to inform the provision of healthcare to this population.
{"title":"Efficacy of the Use of Exergames in Promoting the Mental Health of the Elderly: Protocol of a Systematic Review","authors":"A. Lima, M. T. Moreira, M. S. Ferreira, V. Parola, F. Sampaio, M. D. P. Nóbrega, C. Fernandes","doi":"10.3390/jal3030015","DOIUrl":"https://doi.org/10.3390/jal3030015","url":null,"abstract":"Background: Scientific and technological advancements have significantly impacted our daily lives, and it is not easy to imagine living without their benefits. However, elderly individuals may experience limited access to these resources, impeding their autonomy. To address this, the use of exergames has been proposed to promote the mental health and socialization of older people. This study aims to systematically review the effectiveness of exergames in promoting older people’s mental health and socialization. Methods: The Joanna Briggs Institute’s recommended methodology will be used for a systematic review. Databases relevant to the research topic, such as those regarding gerontologic care, aged rehabilitation, geriatric games, video games, play and playthings, mental health, anxiety, depression, stress, and physiological factors, will be searched for experimental and quasi-experimental studies, as well as randomized studies with and without control groups. Results: The systematic literature review will synthesize findings on the effectiveness of exergames in promoting mental health and socialization in the elderly population. Conclusions: Exergames may have the potential to effectively improve the mental health and socialization of the elderly population. Identifying which exergames are most effective for these purposes is important to inform the provision of healthcare to this population.","PeriodicalId":73588,"journal":{"name":"Journal of ageing and longevity","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48236335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In this article, we develop a tentative philosophy to orchestrate and support possibilities for artful ageing. This effort argues that older adults need a broader range of opportunities to explore the manifold ephemeral, non-rational, and in-between elements of an ageing life. The philosophy is rooted in the notion that older adults need space (literally and metaphorically) to explore and process their existence and that engaging in such processes can entail emancipatory effects in everyday life. The perspective unfolded throughout the article is a philosophical venture, or, rather, a preliminary work, developing the concept of artful ageing as a tool applicable in rethinking and broadening the range of activities occurring in institutional settings dedicated to older adults. Furthermore, the perspective also presents a critical stance towards normative footings and biopolitical agendas embedded in current regimes of active ageing. Artful ageing represents the ambition to enable and support artful lives, events, and activities among residents and participants in care homes and other contexts. We argue that physical and existential spaces are closely intertwined entities and that initiatives aimed at maintaining adequate measures of openness, ambiguity, and sensory intimacy, i.e., events that allow for the experience of metaphorical cracks, can afford artful pockets in which to reside for a while, seek refuge, recharge, stray from the beaten track, and obtain an always partial feeling of emancipation. In qualifying the concept of artful ageing, we hope to open new avenues to contemplate and subsequently initiate activities for older adults that are not just orientated towards physical health in later life. At the same time, our ambition is to develop a critical perspective aimed at challenging existing notions of successful ageing in (re)invigorating the importance of artful processes and experiences as an element inherent to successful ageing, as well.
{"title":"Artful Ageing, Not Just Successful Ageing","authors":"Tine Fristrup, Jon Dag Rasmussen","doi":"10.3390/jal3020014","DOIUrl":"https://doi.org/10.3390/jal3020014","url":null,"abstract":"In this article, we develop a tentative philosophy to orchestrate and support possibilities for artful ageing. This effort argues that older adults need a broader range of opportunities to explore the manifold ephemeral, non-rational, and in-between elements of an ageing life. The philosophy is rooted in the notion that older adults need space (literally and metaphorically) to explore and process their existence and that engaging in such processes can entail emancipatory effects in everyday life. The perspective unfolded throughout the article is a philosophical venture, or, rather, a preliminary work, developing the concept of artful ageing as a tool applicable in rethinking and broadening the range of activities occurring in institutional settings dedicated to older adults. Furthermore, the perspective also presents a critical stance towards normative footings and biopolitical agendas embedded in current regimes of active ageing. Artful ageing represents the ambition to enable and support artful lives, events, and activities among residents and participants in care homes and other contexts. We argue that physical and existential spaces are closely intertwined entities and that initiatives aimed at maintaining adequate measures of openness, ambiguity, and sensory intimacy, i.e., events that allow for the experience of metaphorical cracks, can afford artful pockets in which to reside for a while, seek refuge, recharge, stray from the beaten track, and obtain an always partial feeling of emancipation. In qualifying the concept of artful ageing, we hope to open new avenues to contemplate and subsequently initiate activities for older adults that are not just orientated towards physical health in later life. At the same time, our ambition is to develop a critical perspective aimed at challenging existing notions of successful ageing in (re)invigorating the importance of artful processes and experiences as an element inherent to successful ageing, as well.","PeriodicalId":73588,"journal":{"name":"Journal of ageing and longevity","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45500304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-01Epub Date: 2022-05-31DOI: 10.3390/jal3020013
Ted G Graber, Rosario Maroto, Jill K Thompson, Steven G Widen, Zhaohui Man, Megan L Pajski, Blake B Rasmussen
One inevitable consequence of aging is the gradual deterioration of physical function and exercise capacity, driven in part by the adverse effect of age on muscle tissue. We hypothesized that relationships exist between age-related differentially expressed genes (DEGs) in skeletal muscle and age-associated declines in physical function and exercise capacity. Previously, male C57BL/6mice (6m, months old, 24m, and 28m) were tested for physical function using a composite scoring system (comprehensive functional assessment battery, CFAB) comprised of five well-validated tests of physical function. In this study, total RNA was isolated from tibialis anterior samples (n = 8) randomly selected from each age group in the parent study. Using Next Generation Sequencing RNAseq to determine DEGs during aging (6m vs. 28m, and 6m vs. 24m), we found a greater than five-fold increase in DEGs in 28m compared to the 24m. Furthermore, regression of the normalized expression of each DEG with the CFAB score of the corresponding mouse revealed many more DEGs strongly associated (R ≥ |0.70|) with functional status in the older mice. Gene ontology results indicate highly enriched axon guidance and acetyl choline receptor gene sets, suggesting that denervation/reinnervation flux might potentially play a critical role in functional decline. We conclude that specific age-related DEG patterns are associated with declines in physical function, and the data suggest accelerated aging occurring between 24 and 28 months.
衰老的一个不可避免的后果是身体机能和运动能力的逐渐退化，部分原因是年龄对肌肉组织的不利影响。我们假设骨骼肌中年龄相关的差异表达基因(DEGs)与年龄相关的身体功能和运动能力下降之间存在关系。在此之前，雄性C57BL/ 6小鼠(6岁、6个月、24米和28米)的身体功能测试使用了一种复合评分系统(综合功能评估电池，CFAB)，该系统由五种经过验证的身体功能测试组成。在本研究中，从每个年龄组随机选择的胫骨前肌样本(n = 8)中分离总RNA。使用Next Generation Sequencing RNAseq来测定衰老过程中的deg (6m vs. 28m, 6m vs. 24m)，我们发现28m的deg比24m增加了5倍以上。此外，将每个DEG的归一化表达与相应小鼠的CFAB评分进行回归，发现在老年小鼠中有更多的DEG与功能状态强相关(R≥|0.70|)。基因本体结果表明，轴突引导和乙酰胆碱受体基因组高度富集，表明去神经支配/再神经支配通量可能在功能衰退中发挥关键作用。我们的结论是，特定的年龄相关的DEG模式与身体功能的下降有关，数据表明，在24至28个月之间加速衰老。
{"title":"Skeletal Muscle Transcriptome Alterations Related to Declining Physical Function in Older Mice.","authors":"Ted G Graber, Rosario Maroto, Jill K Thompson, Steven G Widen, Zhaohui Man, Megan L Pajski, Blake B Rasmussen","doi":"10.3390/jal3020013","DOIUrl":"10.3390/jal3020013","url":null,"abstract":"<p><p>One inevitable consequence of aging is the gradual deterioration of physical function and exercise capacity, driven in part by the adverse effect of age on muscle tissue. We hypothesized that relationships exist between age-related differentially expressed genes (DEGs) in skeletal muscle and age-associated declines in physical function and exercise capacity. Previously, male C57BL/6mice (6m, months old, 24m, and 28m) were tested for physical function using a composite scoring system (comprehensive functional assessment battery, CFAB) comprised of five well-validated tests of physical function. In this study, total RNA was isolated from tibialis anterior samples (n = 8) randomly selected from each age group in the parent study. Using Next Generation Sequencing RNAseq to determine DEGs during aging (6m vs. 28m, and 6m vs. 24m), we found a greater than five-fold increase in DEGs in 28m compared to the 24m. Furthermore, regression of the normalized expression of each DEG with the CFAB score of the corresponding mouse revealed many more DEGs strongly associated (R ≥ |0.70|) with functional status in the older mice. Gene ontology results indicate highly enriched axon guidance and acetyl choline receptor gene sets, suggesting that denervation/reinnervation flux might potentially play a critical role in functional decline. We conclude that specific age-related DEG patterns are associated with declines in physical function, and the data suggest accelerated aging occurring between 24 and 28 months.</p>","PeriodicalId":73588,"journal":{"name":"Journal of ageing and longevity","volume":" ","pages":"159-178"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10597580/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42608194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Troels Mygind Jensen, Nicklas Freisleben Lund, Stine Grønbæk Jensen, Anne Hagen Berg, Anne-Marie Mai, K. Petersen, K. Christensen, J. Pedersen, J. Søndergaard, Peter Simonsen
Recent decades have witnessed the coming of age of ‘literary gerontology’, a discipline situated at the intersection of literary studies and gerontology. A key argument of this research is that literature and literary criticism can highlight the complexities and ambiguities of age, ageing and later life. As such, the discipline insists on the relevance of literature within the field of gerontology. This study explores this claim from an interdisciplinary perspective and presents the key findings of an exploratory collaboration between researchers representing literature studies, anthropology, history, public health and medicine. The members of the research team took part in a joint reading, analysis and discussion of Danish author Ane Riel’s novel, Clockwork, which depicts an ageing protagonist’s reconcilement with old age and death. These efforts resulted in dual dimensions of insight: a realistic dimension, which may be interpreted as a confirmation of the existing knowledge of ageing and wellbeing, characterized by physical and cognitive challenges; and an imaginary dimension, a type of knowledge distilled in the interaction between the reader and the literary work. The reader can be seen to be tasked with identifying with the protagonist, with this process providing a hitherto unknown perspective on how ageing is experienced, how it feels and what it means. The study exemplifies an approach fostering cross-disciplinary inspiration, which may stimulate novel research hypotheses and ultimately inform public health thinking and medical practice.
{"title":"The Literary Old Age at the Intersection of Medical Practice and Public Health—A Cross-Disciplinary Reading of Ane Riel’s Clockwork","authors":"Troels Mygind Jensen, Nicklas Freisleben Lund, Stine Grønbæk Jensen, Anne Hagen Berg, Anne-Marie Mai, K. Petersen, K. Christensen, J. Pedersen, J. Søndergaard, Peter Simonsen","doi":"10.3390/jal3020012","DOIUrl":"https://doi.org/10.3390/jal3020012","url":null,"abstract":"Recent decades have witnessed the coming of age of ‘literary gerontology’, a discipline situated at the intersection of literary studies and gerontology. A key argument of this research is that literature and literary criticism can highlight the complexities and ambiguities of age, ageing and later life. As such, the discipline insists on the relevance of literature within the field of gerontology. This study explores this claim from an interdisciplinary perspective and presents the key findings of an exploratory collaboration between researchers representing literature studies, anthropology, history, public health and medicine. The members of the research team took part in a joint reading, analysis and discussion of Danish author Ane Riel’s novel, Clockwork, which depicts an ageing protagonist’s reconcilement with old age and death. These efforts resulted in dual dimensions of insight: a realistic dimension, which may be interpreted as a confirmation of the existing knowledge of ageing and wellbeing, characterized by physical and cognitive challenges; and an imaginary dimension, a type of knowledge distilled in the interaction between the reader and the literary work. The reader can be seen to be tasked with identifying with the protagonist, with this process providing a hitherto unknown perspective on how ageing is experienced, how it feels and what it means. The study exemplifies an approach fostering cross-disciplinary inspiration, which may stimulate novel research hypotheses and ultimately inform public health thinking and medical practice.","PeriodicalId":73588,"journal":{"name":"Journal of ageing and longevity","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41737592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R. Neill, Conor Cunningham, Maeve O’Doherty, L. Smith, M. Tully
Aging research indicates that there is increased sedentary behaviour and insufficient physical activity levels across the older adult population. There is a growing body of evidence that suggests that pet ownership can have beneficial physical and mental health effects. Data were drawn from the Northern Ireland Cohort for the Longitudinal Study of Ageing (NICOLA). This questionnaire measured general social demographics such as gender, age, and marital status while also examining elements of physical activity, lifestyle factors (drinking status, smoking status), and education. Two items from the short form International Physical Activity Questionnaire recorded moderate and vigorous activity. Respondents were asked if they owned a pet (Yes/No). The results are based on a secondary data analysis. An ordinal logistic regression revealed that an increase in moderate activity days was associated with pet ownership with an odds ratio of 0.111 (95% CI, −0.036 to 0.337), Wald χ2 (1) 15.013, p < 0.001. An increase in vigorous activity days was associated with pet ownership with an odds ratio of 0.039 (95% CI, 0.004 to 0.342), Wald χ2 (1) 8.952, p = 0.003). Amongst older adults in Northern Ireland, those with a pet were more likely to engage in regular physical activity. This study was based on a small specific sample of the population and showed differences in physical activity levels between pet owners and non-pet owners. Additionally, the study showed that physical activity is extremely low among the older adult population, therefore further investigation is warranted on the reasons for these low levels.
{"title":"Pet Ownership and Physical Activity in Older Adults: Cross-Sectional Analyses from the NICOLA Study","authors":"R. Neill, Conor Cunningham, Maeve O’Doherty, L. Smith, M. Tully","doi":"10.3390/jal3020011","DOIUrl":"https://doi.org/10.3390/jal3020011","url":null,"abstract":"Aging research indicates that there is increased sedentary behaviour and insufficient physical activity levels across the older adult population. There is a growing body of evidence that suggests that pet ownership can have beneficial physical and mental health effects. Data were drawn from the Northern Ireland Cohort for the Longitudinal Study of Ageing (NICOLA). This questionnaire measured general social demographics such as gender, age, and marital status while also examining elements of physical activity, lifestyle factors (drinking status, smoking status), and education. Two items from the short form International Physical Activity Questionnaire recorded moderate and vigorous activity. Respondents were asked if they owned a pet (Yes/No). The results are based on a secondary data analysis. An ordinal logistic regression revealed that an increase in moderate activity days was associated with pet ownership with an odds ratio of 0.111 (95% CI, −0.036 to 0.337), Wald χ2 (1) 15.013, p < 0.001. An increase in vigorous activity days was associated with pet ownership with an odds ratio of 0.039 (95% CI, 0.004 to 0.342), Wald χ2 (1) 8.952, p = 0.003). Amongst older adults in Northern Ireland, those with a pet were more likely to engage in regular physical activity. This study was based on a small specific sample of the population and showed differences in physical activity levels between pet owners and non-pet owners. Additionally, the study showed that physical activity is extremely low among the older adult population, therefore further investigation is warranted on the reasons for these low levels.","PeriodicalId":73588,"journal":{"name":"Journal of ageing and longevity","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41372421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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